baclofen has been researched along with Amyotrophic Lateral Sclerosis in 12 studies
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We experienced an anesthetic management with rocuronium and neurostimulator for a surgical patient with amyotrophic lateral sclerosis." | 7.78 | [Anesthetic management for a patient with amyotrophic lateral sclerosis; the neuromuscular monitoring was useful to determine appropriate dosages of rocuronium]. ( Iwabuchi, Y; Kumagai, M; Miyata, M; Nagata, H; Suzuki, K; Wakimoto, M, 2012) |
| "A trial of the antispastic drug baclofen was made in amyotrophic lateral sclerosis." | 7.66 | Trial of baclofen in amyotrophic lateral sclerosis. ( Carey, M; Norris, FH; Sachais, B; U, KS, 1979) |
| "Clinical signs and symptoms of spasticity include hypertonia, involuntary movements (spasms, clonus), decreased range of motion, contractures, and often spasm-related pain." | 6.73 | Intrathecal baclofen for spasticity-related pain in amyotrophic lateral sclerosis: efficacy and factors associated with pain relief. ( Bethoux, FA; Boulis, NM; Gogol, DM; Harrison, M; McClelland, S; Pioro, EP; Schwetz, KM; Stough, DK; Sutliff, MH, 2008) |
| "Intrathecal baclofen (ITB) is a proven, effective treatment for refractory spasticity and chronic pain, with applications ranging from spinal cord injury to amyotrophic lateralsclerosis (ALS)." | 4.31 | Management of high-dose intrathecal baclofen pump explant: A case report. ( Agrawal, M; Belisle Haley, C; Dayal, R; Newton, K; Yeung, B, 2023) |
| "We experienced an anesthetic management with rocuronium and neurostimulator for a surgical patient with amyotrophic lateral sclerosis." | 3.78 | [Anesthetic management for a patient with amyotrophic lateral sclerosis; the neuromuscular monitoring was useful to determine appropriate dosages of rocuronium]. ( Iwabuchi, Y; Kumagai, M; Miyata, M; Nagata, H; Suzuki, K; Wakimoto, M, 2012) |
| "A trial of the antispastic drug baclofen was made in amyotrophic lateral sclerosis." | 3.66 | Trial of baclofen in amyotrophic lateral sclerosis. ( Carey, M; Norris, FH; Sachais, B; U, KS, 1979) |
| "Clinical signs and symptoms of spasticity include hypertonia, involuntary movements (spasms, clonus), decreased range of motion, contractures, and often spasm-related pain." | 2.73 | Intrathecal baclofen for spasticity-related pain in amyotrophic lateral sclerosis: efficacy and factors associated with pain relief. ( Bethoux, FA; Boulis, NM; Gogol, DM; Harrison, M; McClelland, S; Pioro, EP; Schwetz, KM; Stough, DK; Sutliff, MH, 2008) |
| "Baclofen has become increasingly popular in the treatment of spasticity disorders." | 1.33 | An unusual presentation of baclofen overdose. ( Chong, CF; Wang, TL, 2005) |
| "Cramps were quite easily induced by volitional exertion and high-frequency stimulation of the peripheral nerves." | 1.29 | Muscle cramp as the result of impaired GABA function--an electrophysiological and pharmacological observation. ( Matsuoka, H; Mizoguchi, K; Nishimura, Y; Obi, T; Takatsu, M, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (16.67) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 3 (25.00) | 24.3611 |
| 2020's | 2 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Belisle Haley, C | 1 |
| Agrawal, M | 1 |
| Newton, K | 1 |
| Yeung, B | 1 |
| Dayal, R | 1 |
| Boussicault, L | 1 |
| Laffaire, J | 1 |
| Schmitt, P | 1 |
| Rinaudo, P | 1 |
| Callizot, N | 1 |
| Nabirotchkin, S | 1 |
| Hajj, R | 1 |
| Cohen, D | 1 |
| Chang, EY | 1 |
| Ehsan, A | 1 |
| Diana, A | 1 |
| Pillai, R | 1 |
| Bongioanni, P | 1 |
| O'Keeffe, AG | 1 |
| Miller, RG | 1 |
| Moore, DH | 1 |
| Wakimoto, M | 1 |
| Nagata, H | 1 |
| Kumagai, M | 1 |
| Miyata, M | 1 |
| Iwabuchi, Y | 1 |
| Suzuki, K | 1 |
| Chong, CF | 1 |
| Wang, TL | 1 |
| Cristini, J | 1 |
| McClelland, S | 1 |
| Bethoux, FA | 1 |
| Boulis, NM | 1 |
| Sutliff, MH | 1 |
| Stough, DK | 1 |
| Schwetz, KM | 1 |
| Gogol, DM | 1 |
| Harrison, M | 1 |
| Pioro, EP | 1 |
| Obi, T | 1 |
| Mizoguchi, K | 1 |
| Matsuoka, H | 1 |
| Takatsu, M | 1 |
| Nishimura, Y | 1 |
| Marquardt, G | 1 |
| Lorenz, R | 1 |
| Norris, FH | 1 |
| U, KS | 1 |
| Sachais, B | 1 |
| Carey, M | 1 |
| Goldblatt, D | 1 |
2 reviews available for baclofen and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Gamma aminobutyric acid (GABA) modulators for amyotrophic lateral sclerosis/motor neuron disease.
Topics: Adult; Amyotrophic Lateral Sclerosis; Baclofen; Clinical Trials, Phase II as Topic; Clinical Trials, | 2017 |
Misdiagnosis and missed diagnoses in patients with ALS.
Topics: Amyotrophic Lateral Sclerosis; Baclofen; Diagnostic Errors; Early Diagnosis; Education, Medical, Con | 2006 |
1 trial available for baclofen and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Intrathecal baclofen for spasticity-related pain in amyotrophic lateral sclerosis: efficacy and factors associated with pain relief.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Baclofen; Cohort Studies; Female; Humans; Infusion Pumps | 2008 |
9 other studies available for baclofen and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Management of high-dose intrathecal baclofen pump explant: A case report.
Topics: Amyotrophic Lateral Sclerosis; Baclofen; Chronic Pain; Diazepam; Humans; Infusion Pumps, Implantable | 2023 |
Combination of acamprosate and baclofen (PXT864) as a potential new therapy for amyotrophic lateral sclerosis.
Topics: Acamprosate; Amyotrophic Lateral Sclerosis; Animals; Baclofen; Cell Survival; Cells, Cultured; Cereb | 2020 |
Placement of Baclofen Pump Catheter Tip for Upper Extremity Spasticity Management.
Topics: Amyotrophic Lateral Sclerosis; Baclofen; Humans; Infusion Pumps, Implantable; Male; Middle Aged; Mus | 2018 |
[Anesthetic management for a patient with amyotrophic lateral sclerosis; the neuromuscular monitoring was useful to determine appropriate dosages of rocuronium].
Topics: Amyotrophic Lateral Sclerosis; Androstanols; Anesthesia, General; Baclofen; Humans; Infusion Pumps, | 2012 |
An unusual presentation of baclofen overdose.
Topics: Adult; Amyotrophic Lateral Sclerosis; Baclofen; Delirium; Drug Overdose; Humans; Male; Muscle Relaxa | 2005 |
Muscle cramp as the result of impaired GABA function--an electrophysiological and pharmacological observation.
Topics: Amyotrophic Lateral Sclerosis; Baclofen; Clomipramine; Diazepam; Electric Stimulation; Evoked Potent | 1993 |
Intrathecal baclofen for intractable spasticity in amyotrophic lateral sclerosis.
Topics: Adult; Amyotrophic Lateral Sclerosis; Baclofen; Catheters, Indwelling; Disease Progression; Dose-Res | 1999 |
Trial of baclofen in amyotrophic lateral sclerosis.
Topics: Adult; Amyotrophic Lateral Sclerosis; Baclofen; Double-Blind Method; Evaluation Studies as Topic; Fe | 1979 |
Treatment of amyotrophic lateral sclerosis.
Topics: Aging; Amitriptyline; Amyotrophic Lateral Sclerosis; Baclofen; Braces; Dantrolene; Deglutition Disor | 1977 |