Page last updated: 2024-10-23

baclofen and Alcohol Withdrawal Associated Autonomic Hyperactivity

baclofen has been researched along with Alcohol Withdrawal Associated Autonomic Hyperactivity in 5 studies

Research Excerpts

ExcerptRelevanceReference
"Diazepam 20 mg was used up to three times per day, but didn't seem to improve or reduce the anxiety, agitation, visual or auditory hallucinations."1.48Delirium tremens in an AUD patient after an intrathecal baclofen pump induced total alcohol abstinence. ( Calvo, ME; Gunnarsson, T; Hao, M; Smith, L, 2018)
"Baclofen is a γ-aminobutyric acid B (GABA-B) receptor agonist that is approved for spasticity."1.40Assessing alcohol versus baclofen withdrawal syndrome in patients treated with baclofen for alcohol use disorder. ( Bence, C; Bordet, R; Carton, L; Cottencin, O; Deheul, S; Jaillette, E; Rolland, B; Saulnier, F, 2014)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (60.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Calvo, ME1
Gunnarsson, T1
Smith, L1
Hao, M1
Rolland, B1
Jaillette, E1
Carton, L1
Bence, C1
Deheul, S1
Saulnier, F1
Bordet, R1
Cottencin, O1
Addolorato, G2
Leggio, L2
Abenavoli, L2
Caputo, F2
Gasbarrini, G2
Olmedo, R1
Hoffman, RS1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Pilot Study on the Biobehavioral Mechanisms of Baclofen and Alcohol Drinking[NCT01076283]Phase 214 participants (Actual)Interventional2009-12-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Alcohol Drinking

"Whether baclofen, as compared to active placebo, results in lower quantity of alcohol consumed during the Alcohol Self-Administration (ASA).~Consistent with O'Malley et al. 2002, the ASA paradigm allows to use a fixed-dose (the priming drink), followed by a 2-hour free-choice phase when subjects may choose to drink or not up to 8 mini-drinks. Participants receive a monetary compensation of $3 dollars per each mini-drink not consumed; therefore the amount of minidrinks consumed during the 2-hour sessions ranges 0-8, and the monetary compensation ranges $0-24. The quantity of alcohol consumed during the free-choice session is expressed as standard drinking unit, where a standard drink unit contains about 14 grams of pure alcohol (about 0.6 fluid ounces or 1.2 tablespoons)." (NCT01076283)
Timeframe: approximately 8 days after drug administration

Interventionstandard drinking units (Mean)
Baclofen0.17
Cyproheptadine1.43

Alcohol Urge

"Whether baclofen, as compared to active placebo, results in diminished cue-reactivity responses to alcohol cues in terms of urge to drink [as measured by the Alcohol Urge Questionnaire (AUQ)] during the Cue Reactivity.~The Alcohol Urge Questionnaire (AUQ) consists of eight statements about the respondent's feelings and thoughts about drinking as they are completing the questionnaire (i.e., right now). The respondent is asked to respond to each statement about alcohol craving via a 7-item Likert scale ranging from strongly disagree to strongly agree. Each item is scored on a 1 to 7 scale (Strongly Disagree = 1 and Strongly Agree = 7). Items 2 and 7 are reverse scored. A total score is computed by summing the item scores and ranges from 8 (lowest craving value) to 56 (highest craving value). Higher scores reflect greater craving (i.e. worse outcome)." (NCT01076283)
Timeframe: approximately 8 days after drug administration

Interventionunits on a scale (Mean)
Baclofen22.5
Cyproheptadine19.4

Reviews

1 review available for baclofen and Alcohol Withdrawal Associated Autonomic Hyperactivity

ArticleYear
Withdrawal syndromes.
    Emergency medicine clinics of North America, 2000, Volume: 18, Issue:2

    Topics: Alcohol Withdrawal Delirium; Analgesics, Opioid; Baclofen; Emergencies; Emergency Treatment; Ethanol

2000

Other Studies

4 other studies available for baclofen and Alcohol Withdrawal Associated Autonomic Hyperactivity

ArticleYear
Delirium tremens in an AUD patient after an intrathecal baclofen pump induced total alcohol abstinence.
    European review for medical and pharmacological sciences, 2018, Volume: 22, Issue:16

    Topics: Alcohol Abstinence; Alcohol Drinking; Alcohol Withdrawal Delirium; Alcoholism; Baclofen; Diazepam; H

2018
Assessing alcohol versus baclofen withdrawal syndrome in patients treated with baclofen for alcohol use disorder.
    Journal of clinical psychopharmacology, 2014, Volume: 34, Issue:1

    Topics: Adult; Alcohol Abstinence; Alcohol Drinking; Alcohol Withdrawal Delirium; Alcoholism; Baclofen; Conf

2014
Tolerance to baclofen's sedative effect in alcohol-addicted patients: no dissipation after a period of abstinence.
    Psychopharmacology, 2005, Volume: 178, Issue:2-3

    Topics: Alcohol Withdrawal Delirium; Alcoholism; Baclofen; Drug Interactions; Drug Tolerance; Ethanol; Human

2005
Baclofen use in the treatment of alcohol delirium tremens.
    Archives of internal medicine, 2005, Mar-14, Volume: 165, Issue:5

    Topics: Alcohol Withdrawal Delirium; Baclofen; GABA Agonists; Humans

2005