baclofen has been researched along with Alcohol Abuse, Nervous System in 3 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hetzler, BE | 1 |
| Ondracek, JM | 1 |
| Becker, EA | 1 |
| Leggio, L | 1 |
| Garbutt, JC | 1 |
| Addolorato, G | 1 |
| Lee, HY | 1 |
| Naha, N | 1 |
| Li, SP | 1 |
| Jo, MJ | 1 |
| Naseer, MI | 1 |
| Naseer, ML | 1 |
| Park, MS | 1 |
| Park, TJ | 1 |
| Chung, BC | 1 |
| Kim, MO | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Study on the Biobehavioral Mechanisms of Baclofen and Alcohol Drinking[NCT01076283] | Phase 2 | 14 participants (Actual) | Interventional | 2009-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Whether baclofen, as compared to active placebo, results in lower quantity of alcohol consumed during the Alcohol Self-Administration (ASA).~Consistent with O'Malley et al. 2002, the ASA paradigm allows to use a fixed-dose (the priming drink), followed by a 2-hour free-choice phase when subjects may choose to drink or not up to 8 mini-drinks. Participants receive a monetary compensation of $3 dollars per each mini-drink not consumed; therefore the amount of minidrinks consumed during the 2-hour sessions ranges 0-8, and the monetary compensation ranges $0-24. The quantity of alcohol consumed during the free-choice session is expressed as standard drinking unit, where a standard drink unit contains about 14 grams of pure alcohol (about 0.6 fluid ounces or 1.2 tablespoons)." (NCT01076283)
Timeframe: approximately 8 days after drug administration
| Intervention | standard drinking units (Mean) |
|---|---|
| Baclofen | 0.17 |
| Cyproheptadine | 1.43 |
"Whether baclofen, as compared to active placebo, results in diminished cue-reactivity responses to alcohol cues in terms of urge to drink [as measured by the Alcohol Urge Questionnaire (AUQ)] during the Cue Reactivity.~The Alcohol Urge Questionnaire (AUQ) consists of eight statements about the respondent's feelings and thoughts about drinking as they are completing the questionnaire (i.e., right now). The respondent is asked to respond to each statement about alcohol craving via a 7-item Likert scale ranging from strongly disagree to strongly agree. Each item is scored on a 1 to 7 scale (Strongly Disagree = 1 and Strongly Agree = 7). Items 2 and 7 are reverse scored. A total score is computed by summing the item scores and ranges from 8 (lowest craving value) to 56 (highest craving value). Higher scores reflect greater craving (i.e. worse outcome)." (NCT01076283)
Timeframe: approximately 8 days after drug administration
| Intervention | units on a scale (Mean) |
|---|---|
| Baclofen | 22.5 |
| Cyproheptadine | 19.4 |
1 review available for baclofen and Alcohol Abuse, Nervous System
| Article | Year |
|---|---|
Effectiveness and safety of baclofen in the treatment of alcohol dependent patients.
Topics: Alcohol-Induced Disorders, Nervous System; Alcoholism; Animals; Baclofen; Brain; Brain Chemistry; Cl | 2010 |
2 other studies available for baclofen and Alcohol Abuse, Nervous System
| Article | Year |
|---|---|
Baclofen does not counteract the acute effects of ethanol on flash-evoked potentials in Long-Evans rats.
Topics: Acute Disease; Alcohol-Induced Disorders, Nervous System; Animals; Arousal; Baclofen; Drug Synergism | 2008 |
In vivo and in vitro ethanol exposure in prenatal rat brain: GABA(B) receptor modulation on dopamine D(1) receptor and protein kinase A.
Topics: Alcohol-Induced Disorders, Nervous System; Animals; Baclofen; Brain; Cells, Cultured; Central Nervou | 2008 |