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baclofen and Aggression

baclofen has been researched along with Aggression in 16 studies

Aggression: Behavior which may be manifested by destructive and attacking action which is verbal or physical, by covert attitudes of hostility or by obstructionism.

Research Excerpts

ExcerptRelevanceReference
"The possible role of gamma-aminobutyric acid (GABA) in human aggression was evaluated by administering baclofen, a GABA-B agonist and comparing the effects on laboratory measures of aggression and escape among subjects with and without a history of conduct disorder."7.71Acute effects of baclofen, a gamma-aminobutyric acid-B agonist, on laboratory measures of aggressive and escape responses of adult male parolees with and without a history of conduct disorder. ( Cherek, DR; Lane, SD; Pietras, CJ; Sharon, J; Steinberg, JL, 2002)
"The effects of gamma aminobutyric acid (GABA), baclofen, and clonidine was studied on footshock-induced aggression in mice."7.67GABAergic agents and clonidine attenuate footshock-induced aggression in mice. ( Aley, KO; Kulkarni, SK, 1989)
"A 23-year-old man with a history of alcohol dependence was admitted to our hospital after self-intoxication with 2700 mg baclofen and 330 mg mirtazapine."5.43[Aggression and restlessness following baclofen overdose: the narrow line between intoxication and withdrawal symptoms]. ( de Witte, LD; Dekker, D; Kaasjager, K; Kromkamp, M; Veraart, J; Vinkers, CH, 2016)
"For baclofen to escalate aggression, specific stimulation (male intruder) and tonic level of serotonin (dark cycle) are required."3.78Behavioral characterization of escalated aggression induced by GABA(B) receptor activation in the dorsal raphe nucleus. ( Debold, JF; Kim, J; Koide, T; Miczek, KA; Schilit, AN; Takahashi, A, 2012)
"The possible role of gamma-aminobutyric acid (GABA) in human aggression was evaluated by administering baclofen, a GABA-B agonist and comparing the effects on laboratory measures of aggression and escape among subjects with and without a history of conduct disorder."3.71Acute effects of baclofen, a gamma-aminobutyric acid-B agonist, on laboratory measures of aggressive and escape responses of adult male parolees with and without a history of conduct disorder. ( Cherek, DR; Lane, SD; Pietras, CJ; Sharon, J; Steinberg, JL, 2002)
"The effects of gamma aminobutyric acid (GABA), baclofen, and clonidine was studied on footshock-induced aggression in mice."3.67GABAergic agents and clonidine attenuate footshock-induced aggression in mice. ( Aley, KO; Kulkarni, SK, 1989)
"A 23-year-old man with a history of alcohol dependence was admitted to our hospital after self-intoxication with 2700 mg baclofen and 330 mg mirtazapine."1.43[Aggression and restlessness following baclofen overdose: the narrow line between intoxication and withdrawal symptoms]. ( de Witte, LD; Dekker, D; Kaasjager, K; Kromkamp, M; Veraart, J; Vinkers, CH, 2016)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19906 (37.50)18.7374
1990's1 (6.25)18.2507
2000's4 (25.00)29.6817
2010's5 (31.25)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Takahashi, A3
Lee, RX1
Iwasato, T1
Itohara, S1
Arima, H1
Bettler, B1
Miczek, KA3
Koide, T2
de Witte, LD1
Dekker, D1
Veraart, J1
Kromkamp, M1
Kaasjager, K1
Vinkers, CH1
Kwa, C1
Debold, JF2
Lee, R1
Chong, B1
Coccaro, E1
Schilit, AN1
Kim, J1
Cherek, DR1
Lane, SD1
Pietras, CJ1
Sharon, J1
Steinberg, JL1
Amikishieva, AV2
Semendiaeva, SN1
Semendyaeva, SN1
Allikmets, LH1
Rägo, LK1
Rodgers, RJ1
Depaulis, A1
Rudissaar, R1
Pruus, K1
Skrebuhhova-Malmros, T1
Allikmets, L1
Matto, V1
Sulcová, A1
Krsiak, M1
Masek, K1
Delini-Stula, A2
Vassout, A2
File, SE1
Zharkovsky, A1
Gulati, K1
Aley, KO1
Kulkarni, SK1

Trials

1 trial available for baclofen and Aggression

ArticleYear
Growth hormone responses to GABAB receptor challenge with baclofen and impulsivity in healthy control and personality disorder subjects.
    Psychopharmacology, 2011, Volume: 215, Issue:1

    Topics: Administration, Oral; Adult; Aggression; Analysis of Variance; Baclofen; Female; GABA-B Receptor Ago

2011

Other Studies

15 other studies available for baclofen and Aggression

ArticleYear
Glutamate input in the dorsal raphe nucleus as a determinant of escalated aggression in male mice.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015, Apr-22, Volume: 35, Issue:16

    Topics: Aggression; Animals; Baclofen; Dorsal Raphe Nucleus; Dose-Response Relationship, Drug; gamma-Aminobu

2015
[Aggression and restlessness following baclofen overdose: the narrow line between intoxication and withdrawal symptoms].
    Nederlands tijdschrift voor geneeskunde, 2016, Volume: 160

    Topics: Adult; Aggression; Alcoholism; Baclofen; Delirium; Drug Overdose; GABA-B Receptor Agonists; Humans;

2016
GABA(A) receptors in the dorsal raphé nucleus of mice: escalation of aggression after alcohol consumption.
    Psychopharmacology, 2010, Volume: 211, Issue:4

    Topics: Aggression; Animals; Baclofen; Behavior, Animal; Bicuculline; Ethanol; GABA Agonists; GABA Antagonis

2010
Behavioral characterization of escalated aggression induced by GABA(B) receptor activation in the dorsal raphe nucleus.
    Psychopharmacology, 2012, Volume: 224, Issue:1

    Topics: Aggression; Animals; Baclofen; Behavior, Animal; Darkness; Female; GABA-B Receptor Agonists; Light;

2012
Acute effects of baclofen, a gamma-aminobutyric acid-B agonist, on laboratory measures of aggressive and escape responses of adult male parolees with and without a history of conduct disorder.
    Psychopharmacology, 2002, Volume: 164, Issue:2

    Topics: Adult; Aggression; Analysis of Variance; Baclofen; Conduct Disorder; Dose-Response Relationship, Dru

2002
[Effects of baclofen on anxiety level, sexual motivation and olfactory perception in male mice with different psycho-emotional statuses].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2006, Volume: 92, Issue:9

    Topics: Aggression; Animals; Anxiety; Baclofen; Emotions; Female; GABA-B Receptor Agonists; Male; Mice; Mice

2006
Effects of baclofen on anxiety, sexual motivation, and olfactory perception in male mice in different psychoemotional states.
    Neuroscience and behavioral physiology, 2007, Volume: 37, Issue:9

    Topics: Aggression; Animal Communication; Animals; Anxiety; Baclofen; Dose-Response Relationship, Drug; Emot

2007
The action of benzodiazepine antagonist Ro 15-1788 on the effects of GABA-ergic drugs.
    Naunyn-Schmiedeberg's archives of pharmacology, 1983, Volume: 324, Issue:3

    Topics: 3,4-Dihydroxyphenylacetic Acid; Aggression; Animals; Baclofen; Benzodiazepines; Benzodiazepinones; B

1983
GABAergic influences on defensive fighting in rats.
    Pharmacology, biochemistry, and behavior, 1982, Volume: 17, Issue:3

    Topics: Aggression; Aminocaproates; Animals; Baclofen; Bicuculline; Electroshock; gamma-Aminobutyric Acid; H

1982
Involvement of GABAergic neurotransmission in the neurobiology of the apomorphine-induced aggressive behavior paradigm, a model of psychotic behavior in rats.
    Methods and findings in experimental and clinical pharmacology, 2000, Volume: 22, Issue:8

    Topics: Aggression; Animals; Apomorphine; Baclofen; Behavior, Animal; Disease Models, Animal; GABA Agonists;

2000
Effects of baclofen on agonistic behaviour in mice.
    Activitas nervosa superior, 1978, Volume: 20, Issue:4

    Topics: Aggression; Agonistic Behavior; Aminobutyrates; Animals; Baclofen; Behavior, Animal; Humans; Male; M

1978
Modulatory effects of baclofen muscimol and GABA on interspecific aggressive behaviour in the rat.
    Neuropharmacology, 1978, Volume: 17, Issue:12

    Topics: Aggression; Aminobutyrates; Animals; Baclofen; gamma-Aminobutyric Acid; Humans; Male; Muscimol; Olfa

1978
Influence of baclofen and GABA-minetic agents on spontaneous and olfactory-bulb-ablation-induced muricidal behaviour in the rat.
    Arzneimittel-Forschung, 1978, Volume: 28, Issue:9

    Topics: Aggression; Aminobutyrates; Animals; Baclofen; gamma-Aminobutyric Acid; Humans; Male; Motor Activity

1978
Effects of baclofen and nitrendipine on ethanol withdrawal responses in the rat.
    Neuropharmacology, 1991, Volume: 30, Issue:2

    Topics: Aggression; Animals; Anxiety; Baclofen; Diet; Dose-Response Relationship, Drug; Ethanol; Exploratory

1991
GABAergic agents and clonidine attenuate footshock-induced aggression in mice.
    Methods and findings in experimental and clinical pharmacology, 1989, Volume: 11, Issue:9

    Topics: Aggression; Animals; Baclofen; Clonidine; Diazepam; Electroshock; gamma-Aminobutyric Acid; Male; Mic

1989