baclofen has been researched along with Adult-Onset Dystonias in 27 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of the study was to evaluate the use of a novel technique for baclofen delivery using an intrathecal catheter inserted through a lumbar laminotomy with the tip placed at the cisterna magna (supraspinal baclofen (SSB)) for the treatment of severe generalized secondary dystonia." | 8.12 | Supraspinal baclofen for the treatment of secondary generalized dystonia: A case series. ( BeDell, KK; Ceverha, B; Wu, J; Yeh, BY, 2022) |
| "The treatment of spasticity and dystonia in these patients is difficult partly due to the relentless nature of this progressive disorder." | 5.48 | Intrathecal baclofen treatment an option in X-linked adrenoleukodystrophy. ( Ehrstedt, C; Hjartarson, HT; Tedroff, K, 2018) |
| "The patient with CD and writer's cramp did well on a continuous baclofen dose of 186." | 5.33 | Treatment of cervical dystonia and focal hand dystonia by high cervical continuously infused intrathecal baclofen: a report of 2 cases. ( Baxter, T; Chappuis, D; DesLauriers, L; Dykstra, DD; Mendez, A; Stuckey, M, 2005) |
| "The aim of the study was to evaluate the use of a novel technique for baclofen delivery using an intrathecal catheter inserted through a lumbar laminotomy with the tip placed at the cisterna magna (supraspinal baclofen (SSB)) for the treatment of severe generalized secondary dystonia." | 4.12 | Supraspinal baclofen for the treatment of secondary generalized dystonia: A case series. ( BeDell, KK; Ceverha, B; Wu, J; Yeh, BY, 2022) |
| "This is a case of a 19-year-old male with a history of remote severe traumatic brain injury (TBI) with an intrathecal baclofen (ITB) pump for dystonia management." | 4.12 | Behavioral dysregulation exacerbated by intrathecal baclofen in an adolescent with severe traumatic brain injury. ( Lam, NY; Montagnino, J; Patel, H; Pham, K; Qin, ES, 2022) |
| "This single-center study investigated adverse events that occurred in children and adolescent patients treated with intrathecal baclofen (ITB) therapy for spasticity and/or dystonia." | 3.80 | Analysis of complications in 430 consecutive pediatric patients treated with intrathecal baclofen therapy: 14-year experience. ( Antonello, CE; Motta, F, 2014) |
| "The average percent reduction in dystonia was 29." | 3.01 | Deep brain stimulation and intrathecal/intraventricular baclofen for glutaric aciduria type 1: A scoping review, individual patient data analysis, and clinical trials review. ( Hofmann, K; Keating, RF; Oluigbo, CO; Shlobin, NA, 2023) |
| "Current guidelines in the treatments of dystonia, including oral therapy, are prescribed to improve symptoms and to restore functional capacity." | 2.72 | Dystonia and leveraging oral pharmacotherapy. ( Fernandez, HH; Sy, MAC, 2021) |
| "The majority (84%) had focal dystonia, most frequently cervical dystonia and blepharospasm." | 2.66 | Patient-reported responses to medical treatment in primary dystonia. ( Choi, JH; Jeon, B; Kim, HJ; Kim, R; Park, S; Shin, J; Woo, KA; Yoo, D, 2020) |
| "In some of the most common genetic dystonias, such as those caused by TOR1A, THAP1, GCH1 and KMT2B mutations, and idiopathic dystonia, these mechanisms include abnormalities in transcriptional regulation, striatal dopaminergic signalling and synaptic plasticity and a loss of inhibition at neuronal circuits." | 2.58 | Dystonia. ( Balint, B; Bhatia, KP; Jankovic, J; Mencacci, NE; Pisani, A; Rothwell, J; Valente, EM; Vidailhet, M, 2018) |
| "Surgical therapy for the secondary dystonias is generally perceived to be less effective than for primary disease." | 2.48 | Surgical treatment for secondary dystonia. ( Lozano, AM; Tierney, TS, 2012) |
| "aspiration; children; dystonia; epilepsy; pneumonia." | 1.72 | Status Dystonicus with Atypical Presentation in Developmentally Delay Child: A Case Report. ( Dahal, S; Khati, N; Maharjan, G; Yadav, P; Yadav, SK, 2022) |
| "The treatment of spasticity and dystonia in these patients is difficult partly due to the relentless nature of this progressive disorder." | 1.48 | Intrathecal baclofen treatment an option in X-linked adrenoleukodystrophy. ( Ehrstedt, C; Hjartarson, HT; Tedroff, K, 2018) |
| "Case note review of 278 children with dystonia referred to our service." | 1.43 | Medication use in childhood dystonia. ( Kaminska, M; Lin, JP; Lumsden, DE; Tomlin, S, 2016) |
| "DYT16 is an autosomal recessive dystonia-parkinsonism due to putative mutations at PRKRA gene." | 1.38 | DYT16: the original cases. ( Camargos, S; Cardoso, F; Lees, AJ; Singleton, A, 2012) |
| "The patient with CD and writer's cramp did well on a continuous baclofen dose of 186." | 1.33 | Treatment of cervical dystonia and focal hand dystonia by high cervical continuously infused intrathecal baclofen: a report of 2 cases. ( Baxter, T; Chappuis, D; DesLauriers, L; Dykstra, DD; Mendez, A; Stuckey, M, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (11.11) | 29.6817 |
| 2010's | 18 (66.67) | 24.3611 |
| 2020's | 6 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, J | 1 |
| Ceverha, B | 1 |
| Yeh, BY | 1 |
| BeDell, KK | 1 |
| Qin, ES | 1 |
| Patel, H | 1 |
| Montagnino, J | 1 |
| Pham, K | 1 |
| Lam, NY | 1 |
| Yadav, SK | 1 |
| Yadav, P | 1 |
| Maharjan, G | 1 |
| Dahal, S | 1 |
| Khati, N | 1 |
| Shlobin, NA | 1 |
| Hofmann, K | 1 |
| Keating, RF | 1 |
| Oluigbo, CO | 1 |
| Woo, KA | 1 |
| Kim, HJ | 1 |
| Yoo, D | 1 |
| Choi, JH | 1 |
| Shin, J | 1 |
| Park, S | 1 |
| Kim, R | 1 |
| Jeon, B | 1 |
| Sy, MAC | 1 |
| Fernandez, HH | 1 |
| Hjartarson, HT | 1 |
| Ehrstedt, C | 1 |
| Tedroff, K | 1 |
| Balint, B | 1 |
| Mencacci, NE | 1 |
| Valente, EM | 1 |
| Pisani, A | 1 |
| Rothwell, J | 1 |
| Jankovic, J | 1 |
| Vidailhet, M | 1 |
| Bhatia, KP | 1 |
| So, PNH | 1 |
| Castañeda, MRRQ | 1 |
| Morante, ARV | 1 |
| Oliva, RV | 1 |
| Rizzo, G | 1 |
| Bussolin, L | 1 |
| Genitori, L | 1 |
| Zicca, A | 1 |
| Messeri, A | 1 |
| Lenge, M | 1 |
| Giordano, F | 1 |
| Allen, NM | 1 |
| Lin, JP | 2 |
| Lynch, T | 1 |
| King, MD | 1 |
| Motta, F | 1 |
| Antonello, CE | 1 |
| Berweck, S | 1 |
| Lütjen, S | 1 |
| Voss, W | 1 |
| Diebold, U | 1 |
| Mücke, KH | 1 |
| Aisch, A | 1 |
| Ostertag, B | 1 |
| Friedrich, M | 1 |
| Wagner, C | 1 |
| Kudernatsch, M | 1 |
| Granel, M | 1 |
| Kluger, G | 1 |
| Ludwikowski, B | 1 |
| Peraud, A | 1 |
| Rauchenzauner, M | 1 |
| Schroeder, AS | 1 |
| Sprinz, A | 1 |
| Wienand, R | 1 |
| Wilken, B | 1 |
| Kästner, S | 1 |
| Zeches, C | 1 |
| Mall, V | 1 |
| Thakur, SK | 1 |
| Rubin, BA | 1 |
| Harter, DH | 1 |
| Lumsden, DE | 1 |
| Kaminska, M | 1 |
| Tomlin, S | 1 |
| Logan, L | 1 |
| Resseque, B | 1 |
| Dontamsetti, MS | 1 |
| Lang, AE | 1 |
| Chen, R | 1 |
| Bonouvrié, LA | 1 |
| van Schie, PE | 1 |
| Becher, JG | 1 |
| van Ouwerkerk, WJ | 1 |
| Reeuwijk, A | 1 |
| Jeroen Vermeulen, R | 1 |
| Albright, AL | 1 |
| Rocque, BG | 1 |
| Leland Albright, A | 1 |
| Bollo, RJ | 1 |
| Gooch, JL | 1 |
| Walker, ML | 1 |
| Camargos, S | 1 |
| Lees, AJ | 1 |
| Singleton, A | 1 |
| Cardoso, F | 1 |
| Turner, M | 1 |
| Nguyen, HS | 1 |
| Cohen-Gadol, AA | 1 |
| Tierney, TS | 1 |
| Lozano, AM | 1 |
| Flett, PJ | 1 |
| Lew, SM | 1 |
| Psaty, EL | 1 |
| Abbott, R | 1 |
| Dykstra, DD | 1 |
| Mendez, A | 1 |
| Chappuis, D | 1 |
| Baxter, T | 1 |
| DesLauriers, L | 1 |
| Stuckey, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Intrathecal (IT) Baclofen Drug Distribution Pilot Study[NCT02903823] | Phase 4 | 27 participants (Actual) | Interventional | 2016-04-22 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The Modified Ashworth Scale (MAS) is a 6-point scale (Standard MAS scale values: 0, 1, 1.5, 2, 3, or 4) used to evaluate spasticity based on grading muscle tone by moving joints. The MAS scores in this cohort are measured in biceps, triceps and forearm flexor muscles in upper extremities; and quadriceps, hamstrings and gastrocnemius muscles in lower extremities. The score ranges from 0 (no increase in muscle tone) to 4 (affected part(s) rigid in flexion or extension). Improvement in spasticity was a reduction in MAS score by 1 point across a joint tested. Maximal MAS change is the sum of MAS score reduction in all four limbs tested.~This outcome looks at subjects with spasticity of cerebral origin." (NCT02903823)
Timeframe: Baseline to 6 hours post-injection
| Intervention | Participants (Count of Participants) | |||
|---|---|---|---|---|
| Cervical level 4 injection site | Thoracic level 3 injection site | Thoracic level 10 injection site | Lumbar lever 2 injection site | |
| Subjects With Max MAS Change | 8 | 7 | 3 | 3 |
"The Modified Ashworth Scale (MAS) is a 6-point scale (Standard MAS scale values: 0, 1, 1.5, 2, 3, or 4) used to evaluate spasticity based on grading muscle tone by moving joints. The MAS scores in this cohort are measured in biceps, triceps and forearm flexor muscles in upper extremities; and quadriceps, hamstrings and gastrocnemius muscles in lower extremities. The score ranges from 0 (no increase in muscle tone) to 4 (affected part(s) rigid in flexion or extension). Improvement in spasticity was a reduction in MAS score by 1 point across a joint tested. Maximal MAS change is the sum of MAS score reduction in all four limbs tested.~This outcome looks at subjects with spasticity of spinal origin." (NCT02903823)
Timeframe: Baseline to 6 hours post-injection
| Intervention | Participants (Count of Participants) | |||
|---|---|---|---|---|
| Cervical spine level 4 injection site | Thoracic level 3 injection site | Thoracic level 10 injection site | Lumbar level 2 injection site | |
| Subjects With MAS Change - Based on Site of Injection | 4 | 2 | 5 | 3 |
7 reviews available for baclofen and Adult-Onset Dystonias
| Article | Year |
|---|---|
Deep brain stimulation and intrathecal/intraventricular baclofen for glutaric aciduria type 1: A scoping review, individual patient data analysis, and clinical trials review.
Topics: Baclofen; Deep Brain Stimulation; Dystonia; Dystonic Disorders; Humans; Muscle Relaxants, Central; M | 2023 |
Patient-reported responses to medical treatment in primary dystonia.
Topics: Baclofen; Benzodiazepines; Dystonic Disorders; Female; Humans; Levodopa; Male; Medical Records; Pati | 2020 |
Dystonia and leveraging oral pharmacotherapy.
Topics: Baclofen; Dystonia; Dystonic Disorders; Humans; Muscle Contraction | 2021 |
Dystonia.
Topics: Baclofen; Basal Ganglia; Botulinum Toxins, Type A; Dopamine Agents; Dystonia; Dystonic Disorders; GA | 2018 |
Status dystonicus: a practice guide.
Topics: Adolescent; Baclofen; Child; Child, Preschool; Chloral Hydrate; Clonidine; Combined Modality Therapy | 2014 |
Intraventricular vs intrathecal baclofen for secondary dystonia: a comparison of complications.
Topics: Adolescent; Adult; Baclofen; Case-Control Studies; Catheterization; Child; Child, Preschool; Cohort | 2012 |
Surgical treatment for secondary dystonia.
Topics: Baclofen; Basal Ganglia; Botulinum Toxins; Denervation; Dystonic Disorders; Globus Pallidus; Humans; | 2012 |
1 trial available for baclofen and Adult-Onset Dystonias
| Article | Year |
|---|---|
Effects of intrathecal baclofen on daily care in children with secondary generalized dystonia: a pilot study.
Topics: Activities of Daily Living; Adolescent; Baclofen; Child; Double-Blind Method; Dystonic Disorders; Fe | 2011 |
19 other studies available for baclofen and Adult-Onset Dystonias
| Article | Year |
|---|---|
Supraspinal baclofen for the treatment of secondary generalized dystonia: A case series.
Topics: Baclofen; Cohort Studies; Dystonia; Dystonic Disorders; Humans; Infusion Pumps, Implantable; Muscle | 2022 |
Behavioral dysregulation exacerbated by intrathecal baclofen in an adolescent with severe traumatic brain injury.
Topics: Adolescent; Adult; Baclofen; Brain Injuries, Traumatic; Dystonia; Dystonic Disorders; Humans; Infusi | 2022 |
Status Dystonicus with Atypical Presentation in Developmentally Delay Child: A Case Report.
Topics: Baclofen; Child; Child, Preschool; Dystonia; Dystonic Disorders; Female; Gabapentin; Humans; Seizure | 2022 |
Intrathecal baclofen treatment an option in X-linked adrenoleukodystrophy.
Topics: Adrenoleukodystrophy; Baclofen; Child; Dystonia; Dystonic Disorders; Humans; Infusion Pumps, Implant | 2018 |
Muscle spasm-induced exothermia in dystonic cerebral palsy: uncommon and frequently misdiagnosed condition.
Topics: Baclofen; Cerebral Palsy; Diagnosis, Differential; Dystonic Disorders; Electromyography; Fluid Thera | 2019 |
The use of opioids in children receiving intrathecal baclofen therapy.
Topics: Adolescent; Analgesics, Opioid; Baclofen; Child; Dystonic Disorders; Female; Humans; Injections, Spi | 2019 |
Analysis of complications in 430 consecutive pediatric patients treated with intrathecal baclofen therapy: 14-year experience.
Topics: Adolescent; Baclofen; Catheters, Indwelling; Cerebral Palsy; Child; Child, Preschool; Dystonia; Dyst | 2014 |
Use of intrathecal baclofen in children and adolescents: interdisciplinary consensus table 2013.
Topics: Adolescent; Baclofen; Child; Consensus; Dystonic Disorders; Female; Follow-Up Studies; Humans; Injec | 2014 |
Long-term follow-up for lumbar intrathecal baclofen catheters placed using the paraspinal subfascial technique.
Topics: Adolescent; Adult; Baclofen; Catheterization; Catheters, Indwelling; Child; Child, Preschool; Dyston | 2016 |
Medication use in childhood dystonia.
Topics: Adolescent; Antiparkinson Agents; Baclofen; Child; Chloral Hydrate; Cohort Studies; Diazepam; Drug-R | 2016 |
Adult onset primary focal dystonia of the foot: an orthopaedic intervention.
Topics: Baclofen; Combined Modality Therapy; Diagnosis, Differential; Dystonic Disorders; Female; Foot Ortho | 2016 |
Dystonia in complex regional pain syndrome type I.
Topics: Baclofen; Causalgia; Causality; Comorbidity; Diagnosis, Differential; Dystonic Disorders; Extremitie | 2010 |
Technique for insertion of intraventricular baclofen catheters.
Topics: Baclofen; Catheters, Indwelling; Cerebral Ventricles; Dystonic Disorders; Humans; Infusions, Intrave | 2011 |
Stereotactic endoscopic placement of third ventricle catheter for long-term infusion of baclofen in patients with secondary generalized dystonia.
Topics: Adolescent; Baclofen; Catheters, Indwelling; Child; Child, Preschool; Dystonic Disorders; Female; Hu | 2012 |
DYT16: the original cases.
Topics: Adolescent; Adult; Age of Onset; Anti-Dyskinesia Agents; Antiparkinson Agents; Baclofen; Biperiden; | 2012 |
Intraventricular baclofen as an alternative to intrathecal baclofen for intractable spasticity or dystonia: outcomes and technical considerations.
Topics: Adolescent; Adult; Aged; Baclofen; Brain Injuries; Cerebral Palsy; Child; Child, Preschool; Dystonic | 2012 |
Re: Status dystonicus and Hallervorden-Spatz disease.
Topics: Baclofen; Child; Dystonic Disorders; Humans; Male; Muscle Relaxants, Central; Pantothenate Kinase-As | 2004 |
An unusual cause of overdose after baclofen pump implantation: case report.
Topics: Adolescent; Baclofen; Cerebral Palsy; Consciousness Disorders; Contrast Media; Drug Overdose; Dyston | 2005 |
Treatment of cervical dystonia and focal hand dystonia by high cervical continuously infused intrathecal baclofen: a report of 2 cases.
Topics: Baclofen; Dystonic Disorders; Female; Humans; Infusions, Parenteral; Male; Middle Aged; Muscle Relax | 2005 |