baclofen has been researched along with Addiction, Opioid in 14 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Study outcomes will determine what dose of baclofen is safe to prescribe to those receiving methadone, to inform a subsequent proof-of-concept trial of the efficacy baclofen to facilitate opiate detoxification." | 3.11 | FORWARDS-1: an adaptive, single-blind, placebo-controlled ascending dose study of acute baclofen on safety parameters in opioid dependence during methadone-maintenance treatment-a pharmacokinetic-pharmacodynamic study. ( Barker, D; Cro, S; Lingford-Hughes, AR; Mozgunov, P; Nahar, L; Paterson, LM; Paterson, S; Phillips, R; Smith, C, 2022) |
| "All patients met the DSM IV criteria for opioid dependence." | 2.70 | Baclofen versus clonidine in the treatment of opiates withdrawal, side-effects aspect: a double-blind randomized controlled trial. ( Ahmadi-Abhari, SA; Akhondzadeh, S; Assadi, SM; Farzanehgan, ZM; Kamlipour, A; Shabestari, OL, 2001) |
| "Buprenorphine was superior to clonidine in controlling severe withdrawal symptoms in an outpatient setting (RR 0." | 2.58 | Pharmacological therapies for management of opium withdrawal. ( Amato, L; Amin-Esmaeili, M; Gholami, J; Hoseinie, L; Rahimi-Movaghar, A; Yousefi-Nooraie, R, 2018) |
| "Methadone and buprenorphine have pharmacologic properties that are concerning for a high risk of drug-drug interactions (DDIs)." | 1.72 | Identifying Clinically Relevant Drug-Drug Interactions With Methadone and Buprenorphine: A Translational Approach to Signal Detection. ( Acton, EK; Bilker, WB; Brensinger, CM; Dawwas, GK; Hennessy, S; Leonard, CE; Li, L; Miano, TA; Neuman, M; Nguyen, TPP; Soprano, SE; Wang, L; Woody, G; Yu, E, 2022) |
| " A smoked cocaine dose-response curve (0, 12, 25, 50 mg) was determined twice: on days 3-4 and days 6-7 of each baclofen maintenance condition." | 1.33 | Effects of baclofen on cocaine self-administration: opioid- and nonopioid-dependent volunteers. ( Foltin, RW; Haney, M; Hart, CL, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (14.29) | 18.7374 |
| 1990's | 3 (21.43) | 18.2507 |
| 2000's | 4 (28.57) | 29.6817 |
| 2010's | 2 (14.29) | 24.3611 |
| 2020's | 3 (21.43) | 2.80 |
| Authors | Studies |
|---|---|
| Miano, TA | 1 |
| Wang, L | 1 |
| Leonard, CE | 1 |
| Brensinger, CM | 1 |
| Acton, EK | 1 |
| Dawwas, GK | 1 |
| Bilker, WB | 1 |
| Soprano, SE | 1 |
| Nguyen, TPP | 1 |
| Woody, G | 1 |
| Yu, E | 1 |
| Neuman, M | 1 |
| Li, L | 1 |
| Hennessy, S | 1 |
| Paterson, LM | 1 |
| Barker, D | 1 |
| Cro, S | 1 |
| Mozgunov, P | 1 |
| Phillips, R | 1 |
| Smith, C | 1 |
| Nahar, L | 1 |
| Paterson, S | 1 |
| Lingford-Hughes, AR | 1 |
| Reiner, DJ | 1 |
| Lofaro, OM | 1 |
| Applebey, SV | 1 |
| Korah, H | 1 |
| Venniro, M | 1 |
| Cifani, C | 1 |
| Bossert, JM | 1 |
| Shaham, Y | 1 |
| Rahimi-Movaghar, A | 2 |
| Gholami, J | 1 |
| Amato, L | 1 |
| Hoseinie, L | 1 |
| Yousefi-Nooraie, R | 2 |
| Amin-Esmaeili, M | 2 |
| Hefazi, M | 1 |
| Assadi, SM | 2 |
| Radgoodarzi, R | 1 |
| Ahmadi-Abhari, SA | 2 |
| Haney, M | 1 |
| Hart, CL | 1 |
| Foltin, RW | 1 |
| Gold, MS | 1 |
| Dackis, CA | 1 |
| Washton, AM | 1 |
| Jaffe, JH | 1 |
| Kanzler, M | 1 |
| Brady, R | 1 |
| Friedman, L | 1 |
| Ling, W | 1 |
| Shoptaw, S | 1 |
| Majewska, D | 1 |
| Capasso, A | 1 |
| Xi, ZX | 1 |
| Stein, EA | 1 |
| Akhondzadeh, S | 1 |
| Shabestari, OL | 1 |
| Farzanehgan, ZM | 1 |
| Kamlipour, A | 1 |
| Krystal, JH | 1 |
| McDougle, CJ | 1 |
| Kosten, TR | 1 |
| Price, LH | 1 |
| Aghajanian, GK | 1 |
| Charney, DS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluating the Safety of Acute Baclofen in Methadone-maintained Individuals With Opiate Dependence. An Adaptive, Single-blind, Placebo-controlled Ascending Dose Study of Acute Baclofen on Safety Parameters in Opioid Dependence During Methadone-maintenance[NCT05161351] | Phase 4 | 64 participants (Anticipated) | Interventional | 2022-01-11 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for baclofen and Addiction, Opioid
| Article | Year |
|---|---|
Pharmacological therapies for management of opium withdrawal.
Topics: Amantadine; Amines; Baclofen; Buprenorphine; Clonidine; Cyclohexanecarboxylic Acids; Gabapentin; gam | 2018 |
Pharmacological therapies for maintenance treatments of opium dependence.
Topics: Baclofen; Buprenorphine; Drug Administration Schedule; Humans; Maintenance Chemotherapy; Narcotic An | 2013 |
The sequential use of clonidine and naltrexone in the treatment of opiate addicts.
Topics: Adult; Baclofen; Clonidine; Drug Therapy, Combination; Electric Stimulation Therapy; Endorphins; Eth | 1984 |
4 trials available for baclofen and Addiction, Opioid
| Article | Year |
|---|---|
FORWARDS-1: an adaptive, single-blind, placebo-controlled ascending dose study of acute baclofen on safety parameters in opioid dependence during methadone-maintenance treatment-a pharmacokinetic-pharmacodynamic study.
Topics: Analgesics, Opioid; Baclofen; Bayes Theorem; Carbon Dioxide; Cholecalciferol; GABA-B Receptor Agonis | 2022 |
Baclofen for maintenance treatment of opioid dependence: a randomized double-blind placebo-controlled clinical trial [ISRCTN32121581].
Topics: Adolescent; Adult; Baclofen; Behavior, Addictive; Depressive Disorder; Double-Blind Method; Female; | 2003 |
Baclofen as a cocaine anti-craving medication: a preliminary clinical study.
Topics: Adult; Baclofen; Cocaine; Female; GABA Agonists; Humans; Male; Middle Aged; Opioid-Related Disorders | 1998 |
Baclofen versus clonidine in the treatment of opiates withdrawal, side-effects aspect: a double-blind randomized controlled trial.
Topics: Adult; Analgesics; Baclofen; Clonidine; Double-Blind Method; Humans; Male; Muscle Relaxants, Central | 2001 |
7 other studies available for baclofen and Addiction, Opioid
| Article | Year |
|---|---|
Identifying Clinically Relevant Drug-Drug Interactions With Methadone and Buprenorphine: A Translational Approach to Signal Detection.
Topics: Baclofen; Bayes Theorem; Benzodiazepines; Buprenorphine; Clonidine; Drug Interactions; Fluconazole; | 2022 |
Role of Projections between Piriform Cortex and Orbitofrontal Cortex in Relapse to Fentanyl Seeking after Palatable Food Choice-Induced Voluntary Abstinence.
Topics: Analgesics, Opioid; Animals; Baclofen; Choice Behavior; Drug-Seeking Behavior; Female; Fentanyl; Foo | 2020 |
Effects of baclofen on cocaine self-administration: opioid- and nonopioid-dependent volunteers.
Topics: Adult; Baclofen; Cocaine; Cocaine-Related Disorders; Crack Cocaine; Dose-Response Relationship, Drug | 2006 |
Methodology for assessing agents that suppress methadone withdrawal: a study of baclofen.
Topics: Adult; Baclofen; Double-Blind Method; Humans; Male; Methadone; Middle Aged; Opioid-Related Disorders | 1982 |
GABAB receptors are involved in the control of acute opiate withdrawal in isolated tissue.
Topics: Animals; Baclofen; Dose-Response Relationship, Drug; GABA Agonists; GABA-B Receptor Antagonists; Gui | 1999 |
Increased mesolimbic GABA concentration blocks heroin self-administration in the rat.
Topics: 4-Aminobutyrate Transaminase; Animals; Baclofen; Behavior, Animal; Bicuculline; Enzyme Inhibitors; G | 2000 |
Baclofen-assisted detoxification from opiates. A pilot study.
Topics: Adult; Baclofen; Female; Humans; Male; Methadone; Neurologic Examination; Opioid-Related Disorders; | 1992 |