bacillamide-b and Breast-Neoplasms

bacillamide-b has been researched along with Breast-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for bacillamide-b and Breast-Neoplasms

Article	Year
Two new imidazolone-containing alkaloids and further metabolites from the ascomycete fungus Tricladium sp. Chemistry & biodiversity, 2011, Volume: 8, Issue:10 Tricladins A and B (1 and 2, resp.), new imidazolone-containing alkaloids, together with five known metabolites, bacillamides A, B (3 and 4, resp.), 20-hydroxyaflavinine (5), N-(2-phenylethyl)acetamide (6), and N(b)-acetyltryptamine (7), have been isolated from the crude extract of the ascomycete fungus Tricladium sp. The structures of 1 and 2 were elucidated primarily by NMR and MS methods. Compound 2 showed marginal cytotoxicity against MDA-MB-231 human breast cancer cells, whereas the known metabolite 4 displayed an inhibitory effect on HIV-1 replication in C8166 cells. Topics: Alkaloids; Anti-HIV Agents; Antineoplastic Agents, Phytogenic; Ascomycota; Breast Neoplasms; Cell Line, Tumor; Drug Evaluation, Preclinical; Female; HIV-1; Humans; Imidazoles; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Thiazoles; Tryptamines	2011

Article

Year

Two new imidazolone-containing alkaloids and further metabolites from the ascomycete fungus Tricladium sp.

Chemistry & biodiversity, 2011, Volume: 8, Issue:10

Tricladins A and B (1 and 2, resp.), new imidazolone-containing alkaloids, together with five known metabolites, bacillamides A, B (3 and 4, resp.), 20-hydroxyaflavinine (5), N-(2-phenylethyl)acetamide (6), and N(b)-acetyltryptamine (7), have been isolated from the crude extract of the ascomycete fungus Tricladium sp. The structures of 1 and 2 were elucidated primarily by NMR and MS methods. Compound 2 showed marginal cytotoxicity against MDA-MB-231 human breast cancer cells, whereas the known metabolite 4 displayed an inhibitory effect on HIV-1 replication in C8166 cells.

Topics: Alkaloids; Anti-HIV Agents; Antineoplastic Agents, Phytogenic; Ascomycota; Breast Neoplasms; Cell Line, Tumor; Drug Evaluation, Preclinical; Female; HIV-1; Humans; Imidazoles; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Thiazoles; Tryptamines

2011