baci-im and Obesity

baci-im has been researched along with Obesity* in 1 studies

Other Studies

1 other study(ies) available for baci-im and Obesity

Article	Year
Stabilized β-Hairpin Peptide Inhibits Insulin Degrading Enzyme. Journal of medicinal chemistry, 2018, 09-27, Volume: 61, Issue:18 Insulin-degrading enzyme (IDE) plays a critical role in both the proteolytic degradation and inactivation of insulin. The exploration of novel IDE inhibitors could aid in the study of novel therapeutics for type-2 diabetes. Herein, we report a hypothesized stabilized β-hairpin peptide that can efficiently inhibit the enzymatic activity of IDE. The resulting stabilized peptide B35 is demonstrated to activate the AKT phosphorylation pathway in skeletal muscle cells and is shown to slow insulin degradation. An 80 mg kg Topics: Animals; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, Animal; Glucose Tolerance Test; HeLa Cells; Humans; Insulin; Insulysin; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Peptide Fragments	2018

Article

Year

Stabilized β-Hairpin Peptide Inhibits Insulin Degrading Enzyme.

Journal of medicinal chemistry, 2018, 09-27, Volume: 61, Issue:18

Insulin-degrading enzyme (IDE) plays a critical role in both the proteolytic degradation and inactivation of insulin. The exploration of novel IDE inhibitors could aid in the study of novel therapeutics for type-2 diabetes. Herein, we report a hypothesized stabilized β-hairpin peptide that can efficiently inhibit the enzymatic activity of IDE. The resulting stabilized peptide B35 is demonstrated to activate the AKT phosphorylation pathway in skeletal muscle cells and is shown to slow insulin degradation. An 80 mg kg

Topics: Animals; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, Animal; Glucose Tolerance Test; HeLa Cells; Humans; Insulin; Insulysin; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Peptide Fragments

2018