bacampicillin and Tonsillitis

Nine hundred and eleven patients were admitted to a multicentre trial with bacampicillin (Penglobe) in respiratory tract infections. Of these it was possible to evaluate 830 with respect to efficacy and side-effects. In most cases a dosage of 400 mg X 2 was used but in severe cases 800 mg X 2 was used. The clinical outcome was assessed as good for 79% of the patients, while 17% showed an improvement and 3% a failure. The tolerance was good with an over-all incidence of 8% side-effects, of which dyspepsia was the most common.

Topics: Ampicillin; Belgium; Bronchitis; Bronchopneumonia; Clinical Trials as Topic; Drug Eruptions; Drug Tolerance; Dyspepsia; Family Practice; Humans; Otitis Media; Respiratory Tract Infections; Tonsillitis

A clinical trial of bacampicillin was carried out in 20 patients. The antibiotic was found to be effective in acute lobar pneumonia, pyogenic meningitis, acute and chronic bronchitis, acute pharyngitis, acute tonsillitis, cellulitis, furunculosis, and pyomyositis caused by such ampicillin-sensitive organisms as Neisseria meningitidis, Diplococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, Streptococcus pyogenes, Klebsiella pneumoniae, and Escherichia coli. Rash in three patients was the only side effect encountered. It is concluded that while bacampicillin may have overcome some of the disadvantages of ampicillin, it retains its main attributes and some shortcomings.

Topics: Adolescent; Adult; Aged; Ampicillin; Bacterial Infections; Bronchitis; Cellulitis; Child; Clinical Trials as Topic; Female; Furunculosis; Haemophilus Infections; Humans; Male; Meningitis; Middle Aged; Pharyngitis; Pneumonia, Pneumococcal; Respiratory Tract Infections; Staphylococcal Infections; Streptococcal Infections; Tonsillitis

Topics: Acute Disease; Adolescent; Adult; Aged; Ampicillin; Chronic Disease; Female; Humans; Laryngitis; Lymphadenitis; Male; Middle Aged; Otitis Externa; Pharyngitis; Sinusitis; Tonsillitis

We investigated bacampicillin (BAPC) granules in the field of pediatrics. 1) Average serum levels after administration of BAPC granules at a dose of 10 mg/kg as ABPC were 6.8 mug/ml at 1 hour, 1.4 mug/ml at 6 hours. Average urinary excretion rate till 6 hours was 84.5%. Those results were almost same as those obtained with BAPC tablet. 2) We treated patients with acute tonsillitis, lacunar tonsillitis and acute bronchitis by BAPC granules at a dose of 30 approximately 40 mg potency/kg for 3 approximately 5 days, and excellent results were obtained. 3) In the case of streptococcal infections including scarlet fever, pharyngeal streptococci disappeared 1 approximately 2 days after administration and did not reappeared. 4) BAPC granules were easy to intake for children and no abnormal laboratory finding was observed. 5) BAPC granules seem to be useful for treatment of pediatric infections.

Topics: Acute Disease; Ampicillin; Bronchitis; Dosage Forms; Humans; Scarlet Fever; Tonsillitis