aztreonam has been researched along with Urethritis in 5 studies
Aztreonam: A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms.
aztreonam : A synthetic monocyclic beta-lactam antibiotic (monobactam), used primarily to treat infections caused by Gram-negative bacteria. It inhibits mucopeptide synthesis in the bacterial cell wall, thereby blocking peptidoglycan crosslinking.
Urethritis: Inflammation involving the URETHRA. Similar to CYSTITIS, clinical symptoms range from vague discomfort to painful urination (DYSURIA), urethral discharge, or both.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A clinical study of a new monocyclic beta-lactam antibiotic, AZTREONAM (hereafter referred to as AZT) for gonorrheal infections as well as epidemiologic study of gonorrheal infections were made Epidemiology: There was a reflection of the increasing sexual activity of the younger generation; both male and female patients in their twenties were most frequent (male 49." | 7.67 | [Epidemiologic and therapeutic study on gonorrheal infections--one shot therapy by aztreonam]. ( Gohro, T; Igawa, K; Inoke, T; Kato, S; Kumamoto, Y; Sakai, S; Tabata, S; Tamate, H; Tanda, H; Tazuki, J, 1985) |
| " Because of the apparent declining utility of spectinomycin, we studied the efficacy and safety of aztreonam, a synthetic monobactam antibiotic from the Squibb Institute for Medical Research (Princeton, NJ) [3], in the treatment of acute uncomplicated gonococcal urethritis in men." | 5.05 | Effectiveness of aztreonam, a new monobactam antibiotic, against penicillin-resistant gonococci. ( Berg, SW; Harrison, WO; Kerbs, SB; Miller, LK; Sanchez, PL, 1983) |
| " To date, in gonococcal urethritis, after treatment with third generation cephems and aztreonam, clinical failures caused by resistant N." | 3.71 | Emergence of cephem- and aztreonam-high-resistant Neisseria gonorrhoeae that does not produce beta-lactamase. ( Akasaka, S; Inatomi, H; Matsumoto, T; Muratani, T; Takahashi, K; Yamada, Y, 2001) |
| "A clinical study of a new monocyclic beta-lactam antibiotic, AZTREONAM (hereafter referred to as AZT) for gonorrheal infections as well as epidemiologic study of gonorrheal infections were made Epidemiology: There was a reflection of the increasing sexual activity of the younger generation; both male and female patients in their twenties were most frequent (male 49." | 3.67 | [Epidemiologic and therapeutic study on gonorrheal infections--one shot therapy by aztreonam]. ( Gohro, T; Igawa, K; Inoke, T; Kato, S; Kumamoto, Y; Sakai, S; Tabata, S; Tamate, H; Tanda, H; Tazuki, J, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (60.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barbee, LA | 1 |
| Soge, OO | 1 |
| Ocbamichael, N | 1 |
| LeClair, A | 1 |
| Golden, MR | 1 |
| Miller, LK | 1 |
| Sanchez, PL | 1 |
| Berg, SW | 1 |
| Kerbs, SB | 1 |
| Harrison, WO | 1 |
| Okazaki, T | 1 |
| Akasaka, S | 1 |
| Muratani, T | 1 |
| Yamada, Y | 1 |
| Inatomi, H | 1 |
| Takahashi, K | 1 |
| Matsumoto, T | 1 |
| Kumamoto, Y | 1 |
| Sakai, S | 1 |
| Tamate, H | 1 |
| Gohro, T | 1 |
| Inoke, T | 1 |
| Tabata, S | 1 |
| Tanda, H | 1 |
| Kato, S | 1 |
| Igawa, K | 1 |
| Tazuki, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Aztreonam for Pharyngeal Gonorrhea: A Demonstration Study[NCT03867734] | Phase 2/Phase 3 | 32 participants (Actual) | Interventional | 2019-04-05 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Number of individuals with a negative N. gonorrhoeae culture at an anogenital site at test of cure among those who were N. gonorrhoeae culture positive at the respective anatomic site at the enrollment visit. (NCT03867734)
Timeframe: Test of Cure 4-7 days following treatment
| Intervention | Participants (Count of Participants) |
|---|---|
| Efficacy of 2g Aztreonam for Urethral Gonorrhea | 9 |
| Efficacy of 2g Aztreonam for Rectal Gonorrhea | 3 |
Subjects' self-report of injection related pain on a scale from 0 - 10 where 0 is no pain and 10 is the worst pain ever. (NCT03867734)
Timeframe: Immediately following injection
| Intervention | score on a scale (Median) |
|---|---|
| 2g Aztreonam | 2 |
Negative Test of Cure (i.e. Pharyngeal Gonorrhea Culture) after Treatment (NCT03867734)
Timeframe: 4-7 days following treatment
| Intervention | Participants (Count of Participants) |
|---|---|
| Pharyngeal Gonorrhea -- Evaluable Population | 2 |
Subject's report of perceived side effects related to study drug based on responses to standard side effect questionnaire. (NCT03867734)
Timeframe: assessed immediately following injection and 4-7 days after injection
| Intervention | Participants (Count of Participants) | |
|---|---|---|
| reported having a HEADACHE | reported having NAUSEA | |
| 2g Aztreonam | 6 | 1 |
1 trial available for aztreonam and Urethritis
| Article | Year |
|---|---|
Effectiveness of aztreonam, a new monobactam antibiotic, against penicillin-resistant gonococci.
Topics: Anti-Bacterial Agents; Aztreonam; Drug Evaluation; Gonorrhea; Humans; Male; Neisseria gonorrhoeae; P | 1983 |
4 other studies available for aztreonam and Urethritis
| Article | Year |
|---|---|
Single-Arm Open-Label Clinical Trial of Two Grams of Aztreonam for the Treatment of Neisseria gonorrhoeae.
Topics: Anti-Bacterial Agents; Aztreonam; Ceftriaxone; Gonorrhea; Humans; Male; Neisseria gonorrhoeae; Ureth | 2020 |
[Bacteriological and clinical evaluation of the effect of azthreonam on gonorrheal urethritis in man].
Topics: Adult; Anti-Bacterial Agents; Aztreonam; Drug Evaluation; Drug Resistance, Microbial; Gonorrhea; Hum | 1984 |
Emergence of cephem- and aztreonam-high-resistant Neisseria gonorrhoeae that does not produce beta-lactamase.
Topics: Adult; Anti-Infective Agents; Aztreonam; Cefdinir; Ceftriaxone; Cephalosporins; Drug Resistance, Mic | 2001 |
[Epidemiologic and therapeutic study on gonorrheal infections--one shot therapy by aztreonam].
Topics: Adolescent; Adult; Age Factors; Aztreonam; Drug Evaluation; Female; Gonorrhea; Humans; Japan; Male; | 1985 |