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aztreonam and Neutropenia

aztreonam has been researched along with Neutropenia in 26 studies

Aztreonam: A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms.
aztreonam : A synthetic monocyclic beta-lactam antibiotic (monobactam), used primarily to treat infections caused by Gram-negative bacteria. It inhibits mucopeptide synthesis in the bacterial cell wall, thereby blocking peptidoglycan crosslinking.

Neutropenia: A decrease in the number of NEUTROPHILS found in the blood.

Research Excerpts

ExcerptRelevanceReference
"The efficacy and safety of piperacillin/tazobactam plus ceftazidime (PIPC/TAZ+CAZ) versus sulbactam/ampicillin plus aztreonam (SBT/ABPC+AZT) as empirical therapy for febrile neutropenia were assessed in children with hematologic disease and solid tumor."9.14Piperacillin/tazobactam plus ceftazidime versus sulbactam/ampicillin plus aztreonam as empirical therapy for fever in severely neutropenic pediatric patients. ( Iguchi, A; Kaneda, M; Kobayashi, R; Nakajima, M; Sato, T, 2009)
" In the present study, we chose aztreonam as the alternative to aminoglycoside in combination with piperacillin for neutropenic fever in pediatric patients and we evaluated its effectiveness."9.10Piperacillin plus aztreonam for treatment of neutropenic fever. ( Mayumi, M; Takeuchi, M; Tanizawa, A, 2003)
"Fourty-two febrile episodes of 32 patients with hematologic disease during neutropenia were treated with two randomly assigned antibiotic combinations of either piperacillin plus gentamicin or piperacillin plus aztreonam."9.07[Aztreonam or gentamicin combined with piperacillin as empiric antibiotic therapy during neutropenia of patients with hematologic diseases]. ( Murase, T, 1992)
"The efficacy of aztreonam in combination with vancomycin was compared with that of gentamicin plus piperacillin as empirical antibiotic treatment for fever in 61 neutropenic patients."9.07Aztreonam plus vancomycin versus gentamicin plus piperacillin as empirical therapy for the treatment of fever in neutropenic patients: a randomised controlled study. ( Kelsey, SM; Newland, AC; Shaw, E, 1992)
" We evaluated the efficacy of a combined antibiotic regimen of monobactam (aztreonam) and antipseudomonal penicillin (piperacillin) in treating neutropenic fever episodes in gynecologic-oncology patients receiving cisplatin-based chemotherapy."7.70Aztreonam plus piperacillin--empiric treatment of neutropenic fever in gynecology-oncology patients receiving cisplatin-based chemotherapy. ( Altaras, M; Beyth, Y; Chowers, M; Fishman, A; Lang, R, 1998)
"The efficacy and safety of piperacillin/tazobactam plus ceftazidime (PIPC/TAZ+CAZ) versus sulbactam/ampicillin plus aztreonam (SBT/ABPC+AZT) as empirical therapy for febrile neutropenia were assessed in children with hematologic disease and solid tumor."5.14Piperacillin/tazobactam plus ceftazidime versus sulbactam/ampicillin plus aztreonam as empirical therapy for fever in severely neutropenic pediatric patients. ( Iguchi, A; Kaneda, M; Kobayashi, R; Nakajima, M; Sato, T, 2009)
" In the present study, we chose aztreonam as the alternative to aminoglycoside in combination with piperacillin for neutropenic fever in pediatric patients and we evaluated its effectiveness."5.10Piperacillin plus aztreonam for treatment of neutropenic fever. ( Mayumi, M; Takeuchi, M; Tanizawa, A, 2003)
"Fourty-two febrile episodes of 32 patients with hematologic disease during neutropenia were treated with two randomly assigned antibiotic combinations of either piperacillin plus gentamicin or piperacillin plus aztreonam."5.07[Aztreonam or gentamicin combined with piperacillin as empiric antibiotic therapy during neutropenia of patients with hematologic diseases]. ( Murase, T, 1992)
"The efficacy of aztreonam in combination with vancomycin was compared with that of gentamicin plus piperacillin as empirical antibiotic treatment for fever in 61 neutropenic patients."5.07Aztreonam plus vancomycin versus gentamicin plus piperacillin as empirical therapy for the treatment of fever in neutropenic patients: a randomised controlled study. ( Kelsey, SM; Newland, AC; Shaw, E, 1992)
" Thus, both the adverse prognostic effect of leukemia as an underlying disease and the poorer results obtained using aztreonam-containing regimens were evident only with certain outcome definitions."5.06The effect of different measures of outcome on the results of studies of empiric antibiotic therapy in febrile neutropenic patients. ( Elliott, CR; Pater, JL, 1988)
" We evaluated the efficacy of a combined antibiotic regimen of monobactam (aztreonam) and antipseudomonal penicillin (piperacillin) in treating neutropenic fever episodes in gynecologic-oncology patients receiving cisplatin-based chemotherapy."3.70Aztreonam plus piperacillin--empiric treatment of neutropenic fever in gynecology-oncology patients receiving cisplatin-based chemotherapy. ( Altaras, M; Beyth, Y; Chowers, M; Fishman, A; Lang, R, 1998)
"There was one infection-related death among patients assigned to AAT therapy and also one among those assigned to LAT therapy."2.66[Empiric therapy with aztreonam for febrile neutropenic patients with hematological malignancies]. ( Ichimaru, M; Moriuchi, Y; Soda, H; Tomonaga, M; Toriya, K, 1989)
"The treatment of bacterial infections in neutropenic cancer patients presents a serious challenge to physicians."2.38Aztreonam in the prevention and treatment of infection in neutropenic cancer patients. ( Bodey, GP; Elting, L; Rolston, KV, 1990)
"Aztreonam is a monocyclic beta-lactam antibiotic that inhibits aerobic gram-negative bacilli, including beta-lactamase-producing species."1.27Current state of infectious diseases--potential areas of directed therapy with aztreonam. ( Neu, HC, 1985)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19906 (23.08)18.7374
1990's17 (65.38)18.2507
2000's3 (11.54)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kobayashi, R1
Sato, T1
Nakajima, M1
Kaneda, M1
Iguchi, A1
Fleming, DR1
Ziegler, C1
Baize, T1
Mudd, L1
Goldsmith, GH1
Herzig, RH1
Takeuchi, M1
Tanizawa, A1
Mayumi, M1
Dholakia, N1
Rolston, KV4
Ho, DH1
LeBlanc, B1
Streeter, H1
Dvorak, T1
Bodey, GP5
Rubenstein, EB1
Rolston, K1
Benjamin, RS1
Loewy, J1
Escalante, C1
Manzullo, E1
Hughes, P1
Moreland, B1
Fender, A1
Kennedy, K1
Raad, II1
Whimbey, EE1
Abi-Said, D1
Hachem, RY1
Pandya, RG1
Ghaddar, HM1
Karl, CL1
Toyama, K2
Yaguchi, M1
Mizoguchi, H2
Masuda, M1
Urabe, A2
Ikeda, Y1
Aoki, I1
Shinbo, T1
Togawa, A1
Hirashima, K2
Miura, Y2
Hirose, S1
Tsuruoka, N1
Omine, M1
Kamakura, M1
Saito, T1
Arimori, S1
Aoki, N2
Kuraishi, Y1
Hirai, H1
Asano, S1
Mori, M1
Shirai, T1
Muto, Y1
Takaku, F2
García Sánchez, JE1
Vazquez López, ML1
Blazquez de Castro, AM1
Perez Simon, JA1
Gutierrez, NG1
Martin, IT1
García-Rodríguez, JA1
Fishman, A1
Chowers, M1
Altaras, M1
Beyth, Y1
Lang, R1
Murase, T1
Kelsey, SM1
Shaw, E1
Newland, AC1
Darveau, RP1
Blake, J1
Seachord, CL1
Cosand, WL1
Cunningham, MD1
Cassiano-Clough, L1
Maloney, G1
Adachi, N1
Hashiyama, M1
Matsuda, I1
Heney, D1
Lewis, IJ1
Ghoneim, AT1
Chisholm, P1
Bailey, CC1
Bodey, G1
Reuben, A1
Elting, L3
Kantarjian, H1
Keating, M1
Hagemeister, F1
Koller, C1
Velasquez, W1
Papadopoulos, N1
Nomura, T1
Yamaguchi, H1
Mutoh, Y1
Hirotsu, T1
Akatsuka, J1
Hoshi, Y1
Uchiyama, H1
Fujisawa, K1
Kobayashi, N1
Ishidoya, N1
Ohira, M1
Takayama, J1
Ishida, Y1
Rubin, M2
Walsh, T1
Butler, K1
Lee, J1
Lecciones, J1
Weinberger, M1
Roilides, E1
Gress, J1
Marshall, D1
Pizzo, PA2
Moriuchi, Y1
Soda, H1
Toriya, K1
Tomonaga, M1
Ichimaru, M1
Natali, M1
Tonini, G1
Tufo, E1
Leggio, M1
Carassai, A1
Lopez, M1
Elliott, CR1
Pater, JL1
Jones, P1
Jones, PG1
Fainstein, V1
Walters, RS1
Neu, HC1

Reviews

2 reviews available for aztreonam and Neutropenia

ArticleYear
The febrile neutropenic patient: newer options for empirical therapy.
    Haematology and blood transfusion, 1990, Volume: 33

    Topics: Agranulocytosis; Anti-Bacterial Agents; Aztreonam; Bacterial Infections; Carbapenems; Cephalosporins

1990
Aztreonam in the prevention and treatment of infection in neutropenic cancer patients.
    The American journal of medicine, 1990, Mar-23, Volume: 88, Issue:3C

    Topics: Agranulocytosis; Aztreonam; Bacterial Infections; Drug Therapy, Combination; Gram-Negative Bacteria;

1990

Trials

15 trials available for aztreonam and Neutropenia

ArticleYear
Piperacillin/tazobactam plus ceftazidime versus sulbactam/ampicillin plus aztreonam as empirical therapy for fever in severely neutropenic pediatric patients.
    Journal of pediatric hematology/oncology, 2009, Volume: 31, Issue:4

    Topics: Adolescent; Ampicillin; Anti-Bacterial Agents; Aztreonam; beta-Lactams; Ceftazidime; Child; Child, P

2009
Cefepime versus ticarcillin and clavulanate potassium and aztreonam for febrile neutropenia therapy in high-dose chemotherapy patients.
    American journal of clinical oncology, 2003, Volume: 26, Issue:3

    Topics: Adult; Aged; Anti-Bacterial Agents; Antineoplastic Agents; Aztreonam; Cefepime; Cephalosporins; Clav

2003
Piperacillin plus aztreonam for treatment of neutropenic fever.
    Pediatrics international : official journal of the Japan Pediatric Society, 2003, Volume: 45, Issue:3

    Topics: Adolescent; Anti-Bacterial Agents; Aztreonam; Bacterial Infections; Child; Child, Preschool; Drug Th

2003
Outpatient treatment of febrile episodes in low-risk neutropenic patients with cancer.
    Cancer, 1993, Jun-01, Volume: 71, Issue:11

    Topics: Administration, Oral; Adolescent; Adult; Aged; Ambulatory Care; Aztreonam; Bacteremia; Bacterial Inf

1993
A comparison of aztreonam plus vancomycin and imipenem plus vancomycin as initial therapy for febrile neutropenic cancer patients.
    Cancer, 1996, Apr-01, Volume: 77, Issue:7

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Aztreonam; Bacterial Infections;

1996
Effect of recombinant human granulocyte colony-stimulating factor on combination therapy with aztreonam and clindamycin for infections in neutropenic patients with hematologic diseases.
    Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases, 1996, Volume: 70, Issue:12

    Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Aztreonam; Clindamycin; Drug Therapy, Com

1996
[Aztreonam or gentamicin combined with piperacillin as empiric antibiotic therapy during neutropenia of patients with hematologic diseases].
    Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases, 1992, Volume: 66, Issue:2

    Topics: Adolescent; Adult; Aged; Anemia, Aplastic; Aztreonam; Bacterial Infections; Cefamandole; Drug Therap

1992
Aztreonam plus vancomycin versus gentamicin plus piperacillin as empirical therapy for the treatment of fever in neutropenic patients: a randomised controlled study.
    Journal of chemotherapy (Florence, Italy), 1992, Volume: 4, Issue:2

    Topics: Adult; Aztreonam; Bacteremia; Drug Therapy, Combination; Fever; Gentamicins; Gram-Negative Bacteria;

1992
rhG-CSF and aztreonam as prophylaxis against infection in neutropenic children.
    Lancet (London, England), 1991, May-11, Volume: 337, Issue:8750

    Topics: Aztreonam; Bacterial Infections; Child; Drug Evaluation; Female; Granulocyte Colony-Stimulating Fact

1991
Aztreonam therapy in children with febrile neutropenia: a randomized trial of aztreonam plus flucloxacillin versus piperacillin plus gentamicin.
    The Journal of antimicrobial chemotherapy, 1991, Volume: 28, Issue:1

    Topics: Adolescent; Aztreonam; Bacteremia; Child; Child, Preschool; Drug Therapy, Combination; Female; Fever

1991
Comparison of two schedules of cefoperazone plus aztreonam in the treatment of neutropenic patients with fever.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1991, Volume: 10, Issue:7

    Topics: Aztreonam; Bacterial Infections; Cefoperazone; Drug Administration Schedule; Drug Therapy, Combinati

1991
[Clinical evaluation of aztreonam for infections accompanying febrile neutropenic children with hematologic disorders and solid tumors. A cooperative study].
    The Japanese journal of antibiotics, 1990, Volume: 43, Issue:12

    Topics: Adolescent; Age Factors; Aztreonam; Bacterial Infections; Cefmetazole; Child; Child, Preschool; Drug

1990
[Empiric therapy with aztreonam for febrile neutropenic patients with hematological malignancies].
    Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases, 1989, Volume: 63, Issue:9

    Topics: Aztreonam; Drug Evaluation; Drug Therapy, Combination; Fever; Humans; Infections; Leukemia; Lymphoma

1989
The effect of different measures of outcome on the results of studies of empiric antibiotic therapy in febrile neutropenic patients.
    Clinical and investigative medicine. Medecine clinique et experimentale, 1988, Volume: 11, Issue:5

    Topics: Acute Disease; Agranulocytosis; Anti-Bacterial Agents; Aztreonam; Clinical Trials as Topic; Cloxacil

1988
Aztreonam therapy in neutropenic patients with cancer.
    The American journal of medicine, 1986, Volume: 81, Issue:2

    Topics: Adolescent; Adult; Aged; Agranulocytosis; Antineoplastic Combined Chemotherapy Protocols; Aztreonam;

1986

Other Studies

9 other studies available for aztreonam and Neutropenia

ArticleYear
In vitro activity of FK-037, a novel parenteral cephalosporin, against bacterial isolates from neutropenic cancer patients.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1994, Volume: 13, Issue:8

    Topics: Aztreonam; Bacteria; Ceftazidime; Ceftizoxime; Humans; Microbial Sensitivity Tests; Neoplasms; Neutr

1994
Aztreonam/clavulanic acid in the treatment of serious infections caused by Stenotrophomonas maltophilia in neutropenic patients: case reports.
    Journal of chemotherapy (Florence, Italy), 1997, Volume: 9, Issue:3

    Topics: Adult; Aged; Aztreonam; Clavulanic Acid; Clavulanic Acids; Drug Resistance, Multiple; Drug Therapy,

1997
Aztreonam plus piperacillin--empiric treatment of neutropenic fever in gynecology-oncology patients receiving cisplatin-based chemotherapy.
    European journal of gynaecological oncology, 1998, Volume: 19, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Aztreonam; Bacterial

1998
Peptides related to the carboxyl terminus of human platelet factor IV with antibacterial activity.
    The Journal of clinical investigation, 1992, Volume: 90, Issue:2

    Topics: Amino Acid Sequence; Animals; Anti-Bacterial Agents; Aztreonam; Bacterial Infections; Cefepime; Ceph

1992
[Combination therapy with aztreonam and clindamycin on severe infections accompanying neutropenic patients with hematological disorders].
    The Japanese journal of antibiotics, 1990, Volume: 43, Issue:10

    Topics: Adult; Aged; Aztreonam; Bacterial Infections; Clindamycin; Drug Evaluation; Drug Therapy, Combinatio

1990
Monotherapy for empirical management of febrile neutropenic patients.
    NCI monographs : a publication of the National Cancer Institute, 1990, Issue:9

    Topics: Agranulocytosis; Anti-Bacterial Agents; Aztreonam; Cephalosporins; Costs and Cost Analysis; Fever; H

1990
[Aztreonam and oxacillin in the treatment of febrile neutropenic patients with solid tumors].
    La Clinica terapeutica, 1989, Sep-15, Volume: 130, Issue:5

    Topics: Adult; Aged; Agranulocytosis; Aztreonam; Bacterial Infections; Female; Fever; Humans; Male; Middle A

1989
Aztreonam: therapy for infections in cancer patients.
    New Jersey medicine : the journal of the Medical Society of New Jersey, 1986, Volume: Spec No

    Topics: Antineoplastic Agents; Aztreonam; Bacterial Infections; Humans; Kinetics; Neoplasms; Neutropenia

1986
Current state of infectious diseases--potential areas of directed therapy with aztreonam.
    The American journal of medicine, 1985, Feb-08, Volume: 78, Issue:2A

    Topics: Abdomen; Anti-Bacterial Agents; Arthritis, Infectious; Aztreonam; Bacterial Infections; Biliary Trac

1985