aztreonam has been researched along with Neutropenia in 26 studies
Aztreonam: A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms.
aztreonam : A synthetic monocyclic beta-lactam antibiotic (monobactam), used primarily to treat infections caused by Gram-negative bacteria. It inhibits mucopeptide synthesis in the bacterial cell wall, thereby blocking peptidoglycan crosslinking.
Neutropenia: A decrease in the number of NEUTROPHILS found in the blood.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The efficacy and safety of piperacillin/tazobactam plus ceftazidime (PIPC/TAZ+CAZ) versus sulbactam/ampicillin plus aztreonam (SBT/ABPC+AZT) as empirical therapy for febrile neutropenia were assessed in children with hematologic disease and solid tumor." | 9.14 | Piperacillin/tazobactam plus ceftazidime versus sulbactam/ampicillin plus aztreonam as empirical therapy for fever in severely neutropenic pediatric patients. ( Iguchi, A; Kaneda, M; Kobayashi, R; Nakajima, M; Sato, T, 2009) |
| " In the present study, we chose aztreonam as the alternative to aminoglycoside in combination with piperacillin for neutropenic fever in pediatric patients and we evaluated its effectiveness." | 9.10 | Piperacillin plus aztreonam for treatment of neutropenic fever. ( Mayumi, M; Takeuchi, M; Tanizawa, A, 2003) |
| "Fourty-two febrile episodes of 32 patients with hematologic disease during neutropenia were treated with two randomly assigned antibiotic combinations of either piperacillin plus gentamicin or piperacillin plus aztreonam." | 9.07 | [Aztreonam or gentamicin combined with piperacillin as empiric antibiotic therapy during neutropenia of patients with hematologic diseases]. ( Murase, T, 1992) |
| "The efficacy of aztreonam in combination with vancomycin was compared with that of gentamicin plus piperacillin as empirical antibiotic treatment for fever in 61 neutropenic patients." | 9.07 | Aztreonam plus vancomycin versus gentamicin plus piperacillin as empirical therapy for the treatment of fever in neutropenic patients: a randomised controlled study. ( Kelsey, SM; Newland, AC; Shaw, E, 1992) |
| " We evaluated the efficacy of a combined antibiotic regimen of monobactam (aztreonam) and antipseudomonal penicillin (piperacillin) in treating neutropenic fever episodes in gynecologic-oncology patients receiving cisplatin-based chemotherapy." | 7.70 | Aztreonam plus piperacillin--empiric treatment of neutropenic fever in gynecology-oncology patients receiving cisplatin-based chemotherapy. ( Altaras, M; Beyth, Y; Chowers, M; Fishman, A; Lang, R, 1998) |
| "The efficacy and safety of piperacillin/tazobactam plus ceftazidime (PIPC/TAZ+CAZ) versus sulbactam/ampicillin plus aztreonam (SBT/ABPC+AZT) as empirical therapy for febrile neutropenia were assessed in children with hematologic disease and solid tumor." | 5.14 | Piperacillin/tazobactam plus ceftazidime versus sulbactam/ampicillin plus aztreonam as empirical therapy for fever in severely neutropenic pediatric patients. ( Iguchi, A; Kaneda, M; Kobayashi, R; Nakajima, M; Sato, T, 2009) |
| " In the present study, we chose aztreonam as the alternative to aminoglycoside in combination with piperacillin for neutropenic fever in pediatric patients and we evaluated its effectiveness." | 5.10 | Piperacillin plus aztreonam for treatment of neutropenic fever. ( Mayumi, M; Takeuchi, M; Tanizawa, A, 2003) |
| "Fourty-two febrile episodes of 32 patients with hematologic disease during neutropenia were treated with two randomly assigned antibiotic combinations of either piperacillin plus gentamicin or piperacillin plus aztreonam." | 5.07 | [Aztreonam or gentamicin combined with piperacillin as empiric antibiotic therapy during neutropenia of patients with hematologic diseases]. ( Murase, T, 1992) |
| "The efficacy of aztreonam in combination with vancomycin was compared with that of gentamicin plus piperacillin as empirical antibiotic treatment for fever in 61 neutropenic patients." | 5.07 | Aztreonam plus vancomycin versus gentamicin plus piperacillin as empirical therapy for the treatment of fever in neutropenic patients: a randomised controlled study. ( Kelsey, SM; Newland, AC; Shaw, E, 1992) |
| " Thus, both the adverse prognostic effect of leukemia as an underlying disease and the poorer results obtained using aztreonam-containing regimens were evident only with certain outcome definitions." | 5.06 | The effect of different measures of outcome on the results of studies of empiric antibiotic therapy in febrile neutropenic patients. ( Elliott, CR; Pater, JL, 1988) |
| " We evaluated the efficacy of a combined antibiotic regimen of monobactam (aztreonam) and antipseudomonal penicillin (piperacillin) in treating neutropenic fever episodes in gynecologic-oncology patients receiving cisplatin-based chemotherapy." | 3.70 | Aztreonam plus piperacillin--empiric treatment of neutropenic fever in gynecology-oncology patients receiving cisplatin-based chemotherapy. ( Altaras, M; Beyth, Y; Chowers, M; Fishman, A; Lang, R, 1998) |
| "There was one infection-related death among patients assigned to AAT therapy and also one among those assigned to LAT therapy." | 2.66 | [Empiric therapy with aztreonam for febrile neutropenic patients with hematological malignancies]. ( Ichimaru, M; Moriuchi, Y; Soda, H; Tomonaga, M; Toriya, K, 1989) |
| "The treatment of bacterial infections in neutropenic cancer patients presents a serious challenge to physicians." | 2.38 | Aztreonam in the prevention and treatment of infection in neutropenic cancer patients. ( Bodey, GP; Elting, L; Rolston, KV, 1990) |
| "Aztreonam is a monocyclic beta-lactam antibiotic that inhibits aerobic gram-negative bacilli, including beta-lactamase-producing species." | 1.27 | Current state of infectious diseases--potential areas of directed therapy with aztreonam. ( Neu, HC, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (23.08) | 18.7374 |
| 1990's | 17 (65.38) | 18.2507 |
| 2000's | 3 (11.54) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kobayashi, R | 1 |
| Sato, T | 1 |
| Nakajima, M | 1 |
| Kaneda, M | 1 |
| Iguchi, A | 1 |
| Fleming, DR | 1 |
| Ziegler, C | 1 |
| Baize, T | 1 |
| Mudd, L | 1 |
| Goldsmith, GH | 1 |
| Herzig, RH | 1 |
| Takeuchi, M | 1 |
| Tanizawa, A | 1 |
| Mayumi, M | 1 |
| Dholakia, N | 1 |
| Rolston, KV | 4 |
| Ho, DH | 1 |
| LeBlanc, B | 1 |
| Streeter, H | 1 |
| Dvorak, T | 1 |
| Bodey, GP | 5 |
| Rubenstein, EB | 1 |
| Rolston, K | 1 |
| Benjamin, RS | 1 |
| Loewy, J | 1 |
| Escalante, C | 1 |
| Manzullo, E | 1 |
| Hughes, P | 1 |
| Moreland, B | 1 |
| Fender, A | 1 |
| Kennedy, K | 1 |
| Raad, II | 1 |
| Whimbey, EE | 1 |
| Abi-Said, D | 1 |
| Hachem, RY | 1 |
| Pandya, RG | 1 |
| Ghaddar, HM | 1 |
| Karl, CL | 1 |
| Toyama, K | 2 |
| Yaguchi, M | 1 |
| Mizoguchi, H | 2 |
| Masuda, M | 1 |
| Urabe, A | 2 |
| Ikeda, Y | 1 |
| Aoki, I | 1 |
| Shinbo, T | 1 |
| Togawa, A | 1 |
| Hirashima, K | 2 |
| Miura, Y | 2 |
| Hirose, S | 1 |
| Tsuruoka, N | 1 |
| Omine, M | 1 |
| Kamakura, M | 1 |
| Saito, T | 1 |
| Arimori, S | 1 |
| Aoki, N | 2 |
| Kuraishi, Y | 1 |
| Hirai, H | 1 |
| Asano, S | 1 |
| Mori, M | 1 |
| Shirai, T | 1 |
| Muto, Y | 1 |
| Takaku, F | 2 |
| García Sánchez, JE | 1 |
| Vazquez López, ML | 1 |
| Blazquez de Castro, AM | 1 |
| Perez Simon, JA | 1 |
| Gutierrez, NG | 1 |
| Martin, IT | 1 |
| García-Rodríguez, JA | 1 |
| Fishman, A | 1 |
| Chowers, M | 1 |
| Altaras, M | 1 |
| Beyth, Y | 1 |
| Lang, R | 1 |
| Murase, T | 1 |
| Kelsey, SM | 1 |
| Shaw, E | 1 |
| Newland, AC | 1 |
| Darveau, RP | 1 |
| Blake, J | 1 |
| Seachord, CL | 1 |
| Cosand, WL | 1 |
| Cunningham, MD | 1 |
| Cassiano-Clough, L | 1 |
| Maloney, G | 1 |
| Adachi, N | 1 |
| Hashiyama, M | 1 |
| Matsuda, I | 1 |
| Heney, D | 1 |
| Lewis, IJ | 1 |
| Ghoneim, AT | 1 |
| Chisholm, P | 1 |
| Bailey, CC | 1 |
| Bodey, G | 1 |
| Reuben, A | 1 |
| Elting, L | 3 |
| Kantarjian, H | 1 |
| Keating, M | 1 |
| Hagemeister, F | 1 |
| Koller, C | 1 |
| Velasquez, W | 1 |
| Papadopoulos, N | 1 |
| Nomura, T | 1 |
| Yamaguchi, H | 1 |
| Mutoh, Y | 1 |
| Hirotsu, T | 1 |
| Akatsuka, J | 1 |
| Hoshi, Y | 1 |
| Uchiyama, H | 1 |
| Fujisawa, K | 1 |
| Kobayashi, N | 1 |
| Ishidoya, N | 1 |
| Ohira, M | 1 |
| Takayama, J | 1 |
| Ishida, Y | 1 |
| Rubin, M | 2 |
| Walsh, T | 1 |
| Butler, K | 1 |
| Lee, J | 1 |
| Lecciones, J | 1 |
| Weinberger, M | 1 |
| Roilides, E | 1 |
| Gress, J | 1 |
| Marshall, D | 1 |
| Pizzo, PA | 2 |
| Moriuchi, Y | 1 |
| Soda, H | 1 |
| Toriya, K | 1 |
| Tomonaga, M | 1 |
| Ichimaru, M | 1 |
| Natali, M | 1 |
| Tonini, G | 1 |
| Tufo, E | 1 |
| Leggio, M | 1 |
| Carassai, A | 1 |
| Lopez, M | 1 |
| Elliott, CR | 1 |
| Pater, JL | 1 |
| Jones, P | 1 |
| Jones, PG | 1 |
| Fainstein, V | 1 |
| Walters, RS | 1 |
| Neu, HC | 1 |
2 reviews available for aztreonam and Neutropenia
| Article | Year |
|---|---|
The febrile neutropenic patient: newer options for empirical therapy.
Topics: Agranulocytosis; Anti-Bacterial Agents; Aztreonam; Bacterial Infections; Carbapenems; Cephalosporins | 1990 |
Aztreonam in the prevention and treatment of infection in neutropenic cancer patients.
Topics: Agranulocytosis; Aztreonam; Bacterial Infections; Drug Therapy, Combination; Gram-Negative Bacteria; | 1990 |
15 trials available for aztreonam and Neutropenia
| Article | Year |
|---|---|
Piperacillin/tazobactam plus ceftazidime versus sulbactam/ampicillin plus aztreonam as empirical therapy for fever in severely neutropenic pediatric patients.
Topics: Adolescent; Ampicillin; Anti-Bacterial Agents; Aztreonam; beta-Lactams; Ceftazidime; Child; Child, P | 2009 |
Cefepime versus ticarcillin and clavulanate potassium and aztreonam for febrile neutropenia therapy in high-dose chemotherapy patients.
Topics: Adult; Aged; Anti-Bacterial Agents; Antineoplastic Agents; Aztreonam; Cefepime; Cephalosporins; Clav | 2003 |
Piperacillin plus aztreonam for treatment of neutropenic fever.
Topics: Adolescent; Anti-Bacterial Agents; Aztreonam; Bacterial Infections; Child; Child, Preschool; Drug Th | 2003 |
Outpatient treatment of febrile episodes in low-risk neutropenic patients with cancer.
Topics: Administration, Oral; Adolescent; Adult; Aged; Ambulatory Care; Aztreonam; Bacteremia; Bacterial Inf | 1993 |
A comparison of aztreonam plus vancomycin and imipenem plus vancomycin as initial therapy for febrile neutropenic cancer patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Aztreonam; Bacterial Infections; | 1996 |
Effect of recombinant human granulocyte colony-stimulating factor on combination therapy with aztreonam and clindamycin for infections in neutropenic patients with hematologic diseases.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Aztreonam; Clindamycin; Drug Therapy, Com | 1996 |
[Aztreonam or gentamicin combined with piperacillin as empiric antibiotic therapy during neutropenia of patients with hematologic diseases].
Topics: Adolescent; Adult; Aged; Anemia, Aplastic; Aztreonam; Bacterial Infections; Cefamandole; Drug Therap | 1992 |
Aztreonam plus vancomycin versus gentamicin plus piperacillin as empirical therapy for the treatment of fever in neutropenic patients: a randomised controlled study.
Topics: Adult; Aztreonam; Bacteremia; Drug Therapy, Combination; Fever; Gentamicins; Gram-Negative Bacteria; | 1992 |
rhG-CSF and aztreonam as prophylaxis against infection in neutropenic children.
Topics: Aztreonam; Bacterial Infections; Child; Drug Evaluation; Female; Granulocyte Colony-Stimulating Fact | 1991 |
Aztreonam therapy in children with febrile neutropenia: a randomized trial of aztreonam plus flucloxacillin versus piperacillin plus gentamicin.
Topics: Adolescent; Aztreonam; Bacteremia; Child; Child, Preschool; Drug Therapy, Combination; Female; Fever | 1991 |
Comparison of two schedules of cefoperazone plus aztreonam in the treatment of neutropenic patients with fever.
Topics: Aztreonam; Bacterial Infections; Cefoperazone; Drug Administration Schedule; Drug Therapy, Combinati | 1991 |
[Clinical evaluation of aztreonam for infections accompanying febrile neutropenic children with hematologic disorders and solid tumors. A cooperative study].
Topics: Adolescent; Age Factors; Aztreonam; Bacterial Infections; Cefmetazole; Child; Child, Preschool; Drug | 1990 |
[Empiric therapy with aztreonam for febrile neutropenic patients with hematological malignancies].
Topics: Aztreonam; Drug Evaluation; Drug Therapy, Combination; Fever; Humans; Infections; Leukemia; Lymphoma | 1989 |
The effect of different measures of outcome on the results of studies of empiric antibiotic therapy in febrile neutropenic patients.
Topics: Acute Disease; Agranulocytosis; Anti-Bacterial Agents; Aztreonam; Clinical Trials as Topic; Cloxacil | 1988 |
Aztreonam therapy in neutropenic patients with cancer.
Topics: Adolescent; Adult; Aged; Agranulocytosis; Antineoplastic Combined Chemotherapy Protocols; Aztreonam; | 1986 |
9 other studies available for aztreonam and Neutropenia
| Article | Year |
|---|---|
In vitro activity of FK-037, a novel parenteral cephalosporin, against bacterial isolates from neutropenic cancer patients.
Topics: Aztreonam; Bacteria; Ceftazidime; Ceftizoxime; Humans; Microbial Sensitivity Tests; Neoplasms; Neutr | 1994 |
Aztreonam/clavulanic acid in the treatment of serious infections caused by Stenotrophomonas maltophilia in neutropenic patients: case reports.
Topics: Adult; Aged; Aztreonam; Clavulanic Acid; Clavulanic Acids; Drug Resistance, Multiple; Drug Therapy, | 1997 |
Aztreonam plus piperacillin--empiric treatment of neutropenic fever in gynecology-oncology patients receiving cisplatin-based chemotherapy.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Aztreonam; Bacterial | 1998 |
Peptides related to the carboxyl terminus of human platelet factor IV with antibacterial activity.
Topics: Amino Acid Sequence; Animals; Anti-Bacterial Agents; Aztreonam; Bacterial Infections; Cefepime; Ceph | 1992 |
[Combination therapy with aztreonam and clindamycin on severe infections accompanying neutropenic patients with hematological disorders].
Topics: Adult; Aged; Aztreonam; Bacterial Infections; Clindamycin; Drug Evaluation; Drug Therapy, Combinatio | 1990 |
Monotherapy for empirical management of febrile neutropenic patients.
Topics: Agranulocytosis; Anti-Bacterial Agents; Aztreonam; Cephalosporins; Costs and Cost Analysis; Fever; H | 1990 |
[Aztreonam and oxacillin in the treatment of febrile neutropenic patients with solid tumors].
Topics: Adult; Aged; Agranulocytosis; Aztreonam; Bacterial Infections; Female; Fever; Humans; Male; Middle A | 1989 |
Aztreonam: therapy for infections in cancer patients.
Topics: Antineoplastic Agents; Aztreonam; Bacterial Infections; Humans; Kinetics; Neoplasms; Neutropenia | 1986 |
Current state of infectious diseases--potential areas of directed therapy with aztreonam.
Topics: Abdomen; Anti-Bacterial Agents; Arthritis, Infectious; Aztreonam; Bacterial Infections; Biliary Trac | 1985 |