aztreonam has been researched along with Liver Failure in 2 studies
Aztreonam: A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms.
aztreonam : A synthetic monocyclic beta-lactam antibiotic (monobactam), used primarily to treat infections caused by Gram-negative bacteria. It inhibits mucopeptide synthesis in the bacterial cell wall, thereby blocking peptidoglycan crosslinking.
Liver Failure: Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fifty patients admitted with fulminant hepatic failure and clinically suspected infection were allocated to receive either aztreonam and vancomycin or piperacillin and gentamicin as first line treatment." | 9.07 | An open, comparative trial of aztreonam with vancomycin and gentamicin with piperacillin in patients with fulminant hepatic failure. ( Casewell, MW; Fagan, E; Philpott-Howard, J; Rolando, N; Wade, JJ; Williams, R, 1992) |
| "Fifty patients admitted with fulminant hepatic failure and clinically suspected infection were allocated to receive either aztreonam and vancomycin or piperacillin and gentamicin as first line treatment." | 5.07 | An open, comparative trial of aztreonam with vancomycin and gentamicin with piperacillin in patients with fulminant hepatic failure. ( Casewell, MW; Fagan, E; Philpott-Howard, J; Rolando, N; Wade, JJ; Williams, R, 1992) |
| "Plasma concentrations of aztreonam follow a 2-compartment open model with a distribution half-life of 0." | 2.39 | Clinical pharmacokinetics of aztreonam. An update. ( Mattie, H, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mattie, H | 1 |
| Rolando, N | 1 |
| Wade, JJ | 1 |
| Fagan, E | 1 |
| Philpott-Howard, J | 1 |
| Casewell, MW | 1 |
| Williams, R | 1 |
1 review available for aztreonam and Liver Failure
| Article | Year |
|---|---|
Clinical pharmacokinetics of aztreonam. An update.
Topics: Absorption; Aztreonam; Blood Proteins; Cystic Fibrosis; Half-Life; Humans; Injections, Intramuscular | 1994 |
1 trial available for aztreonam and Liver Failure
| Article | Year |
|---|---|
An open, comparative trial of aztreonam with vancomycin and gentamicin with piperacillin in patients with fulminant hepatic failure.
Topics: Adolescent; Adult; Aztreonam; Drug Therapy, Combination; Female; Gentamicins; Humans; Liver Failure; | 1992 |