aztreonam and Gonorrhea studies

Aztreonam: A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms.
aztreonam : A synthetic monocyclic beta-lactam antibiotic (monobactam), used primarily to treat infections caused by Gram-negative bacteria. It inhibits mucopeptide synthesis in the bacterial cell wall, thereby blocking peptidoglycan crosslinking.

Gonorrhea: Acute infectious disease characterized by primary invasion of the urogenital tract. The etiologic agent, NEISSERIA GONORRHOEAE, was isolated by Neisser in 1879.

Research Excerpts

Excerpt	Relevance	Reference
"Aztreonam, 1 g intramuscularly, was compared with spectinomycin, 2 g intramuscularly, for uncomplicated gonorrhea."	9.05	Effectiveness of aztreonam for the treatment of gonorrhea. ( Gottlieb, A; Mills, J, 1985)
"A clinical study of a new monocyclic beta-lactam antibiotic, AZTREONAM (hereafter referred to as AZT) for gonorrheal infections as well as epidemiologic study of gonorrheal infections were made Epidemiology: There was a reflection of the increasing sexual activity of the younger generation; both male and female patients in their twenties were most frequent (male 49."	7.67	[Epidemiologic and therapeutic study on gonorrheal infections--one shot therapy by aztreonam]. ( Gohro, T; Igawa, K; Inoke, T; Kato, S; Kumamoto, Y; Sakai, S; Tabata, S; Tamate, H; Tanda, H; Tazuki, J, 1985)
" Because of the apparent declining utility of spectinomycin, we studied the efficacy and safety of aztreonam, a synthetic monobactam antibiotic from the Squibb Institute for Medical Research (Princeton, NJ) [3], in the treatment of acute uncomplicated gonococcal urethritis in men."	5.05	Effectiveness of aztreonam, a new monobactam antibiotic, against penicillin-resistant gonococci. ( Berg, SW; Harrison, WO; Kerbs, SB; Miller, LK; Sanchez, PL, 1983)
"Aztreonam, 1 g intramuscularly, was compared with spectinomycin, 2 g intramuscularly, for uncomplicated gonorrhea."	5.05	Effectiveness of aztreonam for the treatment of gonorrhea. ( Gottlieb, A; Mills, J, 1985)
"Multicenter trials were conducted to determine the safety and efficacy of aztreonam in the treatment of patients with gram-negative bacterial infections."	5.05	Aztreonam: worldwide overview of the treatment of patients with gram-negative infections. ( Bendush, CB; Henry, SA, 1985)
" To date, in gonococcal urethritis, after treatment with third generation cephems and aztreonam, clinical failures caused by resistant N."	3.71	Emergence of cephem- and aztreonam-high-resistant Neisseria gonorrhoeae that does not produce beta-lactamase. ( Akasaka, S; Inatomi, H; Matsumoto, T; Muratani, T; Takahashi, K; Yamada, Y, 2001)
"A clinical study of a new monocyclic beta-lactam antibiotic, AZTREONAM (hereafter referred to as AZT) for gonorrheal infections as well as epidemiologic study of gonorrheal infections were made Epidemiology: There was a reflection of the increasing sexual activity of the younger generation; both male and female patients in their twenties were most frequent (male 49."	3.67	[Epidemiologic and therapeutic study on gonorrheal infections--one shot therapy by aztreonam]. ( Gohro, T; Igawa, K; Inoke, T; Kato, S; Kumamoto, Y; Sakai, S; Tabata, S; Tamate, H; Tanda, H; Tazuki, J, 1985)
"Aztreonam was well tolerated with no adverse effects."	2.66	Treatment of uncomplicated gonorrhoea with single dose aztreonam. ( Crooks, AJ; Evans, DT; Holman, RA; Jones, C; Price, SW, 1986)
"Aztreonam was well tolerated and there were no side-effects."	2.66	Single intramuscular injection of aztreonam in the treatment of uncomplicated gonorrhoea in women. ( Deighton, R; Mohanty, KC; Strachan, RG, 1987)
"Aztreonam appears to be an effective alternative to cephalosporins in the treatment of uncomplicated gonorrhoea, particularly when patients are suspected of being infected by strains with reduced susceptibility to ceftriaxone or are known to be allergic to penicillin."	1.46	Repurposing an old drug: aztreonam as a new treatment strategy for gonorrhoea. ( Calin, R; Davido, B; Dinh, A; Makhloufi, S; Salomon, J; Senard, O, 2017)

Research

Studies (17)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Efficacy of 2 g Aztreonam for N. Gonorrhoeae at Anogenital Sites

Timeframe	Studies, this research(%)	All Research%
pre-1990	11 (64.71)	18.7374
1990's	1 (5.88)	18.2507
2000's	2 (11.76)	29.6817
2010's	1 (5.88)	24.3611
2020's	2 (11.76)	2.80

Authors	Studies
Barbee, LA	2
Golden, MR	2
Soge, OO	1
Ocbamichael, N	1
LeClair, A	1
Davido, B	1
Dinh, A	1
Senard, O	1
Calin, R	1
Makhloufi, S	1
Salomon, J	1
Miller, LK	1
Sanchez, PL	1
Berg, SW	1
Kerbs, SB	1
Harrison, WO	1
Okazaki, T	1
Akasaka, S	2
Muratani, T	2
Yamada, Y	2
Inatomi, H	2
Takahashi, K	2
Matsumoto, T	2
Kobayashi, T	1
Stöberl, C	1
Poitschek, C	1
Söltz-Szöts, J	1
Spencer, RC	1
Talbot, MD	1
Evans, DT	1
Crooks, AJ	1
Jones, C	1
Holman, RA	1
Price, SW	1
Tait, IB	1
Winning, J	1
Sleigh, JD	1
Gottlieb, A	1
Mills, J	1
Mohanty, KC	2
Deighton Fimls, R	1
Strachan, RG	2
Deighton, R	1
Mulcahy, F	1
Barr, K	1
Lacy, C	1
Lacey, R	1
Henry, SA	1
Bendush, CB	1
Kumamoto, Y	1
Sakai, S	1
Tamate, H	1
Gohro, T	1
Inoke, T	1
Tabata, S	1
Tanda, H	1
Kato, S	1
Igawa, K	1
Tazuki, J	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Aztreonam for Pharyngeal Gonorrhea: A Demonstration Study[NCT03867734]	Phase 2/Phase 3	32 participants (Actual)	Interventional	2019-04-05	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Number of individuals with a negative N. gonorrhoeae culture at an anogenital site at test of cure among those who were N. gonorrhoeae culture positive at the respective anatomic site at the enrollment visit. (NCT03867734)
Timeframe: Test of Cure 4-7 days following treatment

Tolerability of 2g Aztreonam IM

Intervention	Participants (Count of Participants)
Efficacy of 2g Aztreonam for Urethral Gonorrhea	9
Efficacy of 2g Aztreonam for Rectal Gonorrhea	3

Subjects' self-report of injection related pain on a scale from 0 - 10 where 0 is no pain and 10 is the worst pain ever. (NCT03867734)
Timeframe: Immediately following injection

Treatment Efficacy of Pharyngeal Gonorrhea as Defined as the Proportion of Study Participants With Positive Pharyngeal Gonorrhea Culture at of Enrollment Whose Test of Cure Pharyngeal Culture is Negative

Intervention	score on a scale (Median)
2g Aztreonam	2

Negative Test of Cure (i.e. Pharyngeal Gonorrhea Culture) after Treatment (NCT03867734)
Timeframe: 4-7 days following treatment

Side Effects of 2g Aztreonam IM

Intervention	Participants (Count of Participants)
Pharyngeal Gonorrhea -- Evaluable Population	2

Subject's report of perceived side effects related to study drug based on responses to standard side effect questionnaire. (NCT03867734)
Timeframe: assessed immediately following injection and 4-7 days after injection

Article	Year
Effectiveness of aztreonam, a new monobactam antibiotic, against penicillin-resistant gonococci. The Journal of infectious diseases, 1983, Volume: 148, Issue:3 Topics: Anti-Bacterial Agents; Aztreonam; Drug Evaluation; Gonorrhea; Humans; Male; Neisseria gonorrhoeae; P	1983
[Aztreonam, a new approach in the therapy of gonorrhea]. Wiener klinische Wochenschrift, 1991, Volume: 103, Issue:9 Topics: Aztreonam; Female; Gonorrhea; Humans; Male; Microbial Sensitivity Tests; Neisseria gonorrhoeae	1991
Treatment of uncomplicated gonorrhoea with single dose aztreonam. Genitourinary medicine, 1986, Volume: 62, Issue:5 Topics: Adult; Aztreonam; Clinical Trials as Topic; Female; Gonorrhea; Humans; Injections, Intramuscular; Ma	1986
Effectiveness of aztreonam for the treatment of gonorrhea. Antimicrobial agents and chemotherapy, 1985, Volume: 27, Issue:2 Topics: Adolescent; Adult; Anti-Bacterial Agents; Aztreonam; Clinical Trials as Topic; Female; Gonorrhea; Hu	1985
A comparative study of aztreonam and procaine penicillin/probenecid in the treatment of uncomplicated gonorrhoea. Scandinavian journal of infectious diseases, 1988, Volume: 20, Issue:1 Topics: Aztreonam; Clinical Trials as Topic; Drug Therapy, Combination; Female; Gonorrhea; Humans; Male; Mic	1988
Single intramuscular injection of aztreonam in the treatment of uncomplicated gonorrhoea in women. Current medical research and opinion, 1987, Volume: 10, Issue:9 Topics: Aztreonam; Drug Evaluation; Female; Gonorrhea; Humans; Injections, Intramuscular; Microbial Sensitiv	1987
Aztreonam: worldwide overview of the treatment of patients with gram-negative infections. The American journal of medicine, 1985, Feb-08, Volume: 78, Issue:2A Topics: Abdomen; Adult; Anti-Bacterial Agents; Arthritis, Infectious; Aztreonam; Bacterial Infections; Clini	1985

Article	Year
Single-Arm Open-Label Clinical Trial of Two Grams of Aztreonam for the Treatment of Neisseria gonorrhoeae. Antimicrobial agents and chemotherapy, 2020, 12-16, Volume: 65, Issue:1 Topics: Anti-Bacterial Agents; Aztreonam; Ceftriaxone; Gonorrhea; Humans; Male; Neisseria gonorrhoeae; Ureth	2020
Repurposing an old drug: aztreonam as a new treatment strategy for gonorrhoea. The Journal of antimicrobial chemotherapy, 2017, 05-01, Volume: 72, Issue:5 Topics: Adult; Anti-Bacterial Agents; Aztreonam; Drug Repositioning; Female; Gonorrhea; Humans; Male; Microb	2017
[Bacteriological and clinical evaluation of the effect of azthreonam on gonorrheal urethritis in man]. The Japanese journal of antibiotics, 1984, Volume: 37, Issue:10 Topics: Adult; Anti-Bacterial Agents; Aztreonam; Drug Evaluation; Drug Resistance, Microbial; Gonorrhea; Hum	1984
Emergence of cephem- and aztreonam-high-resistant Neisseria gonorrhoeae that does not produce beta-lactamase. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2001, Volume: 7, Issue:1 Topics: Adult; Anti-Infective Agents; Aztreonam; Cefdinir; Ceftriaxone; Cephalosporins; Drug Resistance, Mic	2001
Outbreak of cefozopran (penicillin, oral cephems, and aztreonam)-resistant Neisseria gonorrhoeae in Japan. Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:12 Topics: Adult; Anti-Bacterial Agents; Aztreonam; Cefozopran; Cephalosporins; Disease Outbreaks; DNA, Bacteri	2001
The use of aztreonam in the treatment of uncomplicated gonorrhoea. Current medical research and opinion, 1985, Volume: 9, Issue:9 Topics: Aztreonam; Cefuroxime; Female; Gonorrhea; Humans; Injections, Intramuscular; Male; Microbial Sensiti	1985
Single dose aztreonam in treating gonorrhoea. Genitourinary medicine, 1987, Volume: 63, Issue:1 Topics: Adolescent; Adult; Aged; Aztreonam; Female; Gonorrhea; Humans; Injections, Intramuscular; Male; Micr	1987
Lack of disturbance of the gut flora associated with the use of aztreonam for the treatment of gonorrhea. Chemioterapia : international journal of the Mediterranean Society of Chemotherapy, 1987, Volume: 6, Issue:2 Suppl Topics: Adolescent; Adult; Aztreonam; Drug Resistance, Microbial; Enterobacteriaceae; Female; Gonorrhea; Hum	1987
[Epidemiologic and therapeutic study on gonorrheal infections--one shot therapy by aztreonam]. Hinyokika kiyo. Acta urologica Japonica, 1985, Volume: 31, Issue:11 Topics: Adolescent; Adult; Age Factors; Aztreonam; Drug Evaluation; Female; Gonorrhea; Humans; Japan; Male;	1985

aztreonam and Gonorrhea