Page last updated: 2024-10-23

aztreonam and Gonorrhea

aztreonam has been researched along with Gonorrhea in 17 studies

Aztreonam: A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms.
aztreonam : A synthetic monocyclic beta-lactam antibiotic (monobactam), used primarily to treat infections caused by Gram-negative bacteria. It inhibits mucopeptide synthesis in the bacterial cell wall, thereby blocking peptidoglycan crosslinking.

Gonorrhea: Acute infectious disease characterized by primary invasion of the urogenital tract. The etiologic agent, NEISSERIA GONORRHOEAE, was isolated by Neisser in 1879.

Research Excerpts

ExcerptRelevanceReference
"Aztreonam, 1 g intramuscularly, was compared with spectinomycin, 2 g intramuscularly, for uncomplicated gonorrhea."9.05Effectiveness of aztreonam for the treatment of gonorrhea. ( Gottlieb, A; Mills, J, 1985)
"A clinical study of a new monocyclic beta-lactam antibiotic, AZTREONAM (hereafter referred to as AZT) for gonorrheal infections as well as epidemiologic study of gonorrheal infections were made Epidemiology: There was a reflection of the increasing sexual activity of the younger generation; both male and female patients in their twenties were most frequent (male 49."7.67[Epidemiologic and therapeutic study on gonorrheal infections--one shot therapy by aztreonam]. ( Gohro, T; Igawa, K; Inoke, T; Kato, S; Kumamoto, Y; Sakai, S; Tabata, S; Tamate, H; Tanda, H; Tazuki, J, 1985)
" Because of the apparent declining utility of spectinomycin, we studied the efficacy and safety of aztreonam, a synthetic monobactam antibiotic from the Squibb Institute for Medical Research (Princeton, NJ) [3], in the treatment of acute uncomplicated gonococcal urethritis in men."5.05Effectiveness of aztreonam, a new monobactam antibiotic, against penicillin-resistant gonococci. ( Berg, SW; Harrison, WO; Kerbs, SB; Miller, LK; Sanchez, PL, 1983)
"Aztreonam, 1 g intramuscularly, was compared with spectinomycin, 2 g intramuscularly, for uncomplicated gonorrhea."5.05Effectiveness of aztreonam for the treatment of gonorrhea. ( Gottlieb, A; Mills, J, 1985)
"Multicenter trials were conducted to determine the safety and efficacy of aztreonam in the treatment of patients with gram-negative bacterial infections."5.05Aztreonam: worldwide overview of the treatment of patients with gram-negative infections. ( Bendush, CB; Henry, SA, 1985)
" To date, in gonococcal urethritis, after treatment with third generation cephems and aztreonam, clinical failures caused by resistant N."3.71Emergence of cephem- and aztreonam-high-resistant Neisseria gonorrhoeae that does not produce beta-lactamase. ( Akasaka, S; Inatomi, H; Matsumoto, T; Muratani, T; Takahashi, K; Yamada, Y, 2001)
"A clinical study of a new monocyclic beta-lactam antibiotic, AZTREONAM (hereafter referred to as AZT) for gonorrheal infections as well as epidemiologic study of gonorrheal infections were made Epidemiology: There was a reflection of the increasing sexual activity of the younger generation; both male and female patients in their twenties were most frequent (male 49."3.67[Epidemiologic and therapeutic study on gonorrheal infections--one shot therapy by aztreonam]. ( Gohro, T; Igawa, K; Inoke, T; Kato, S; Kumamoto, Y; Sakai, S; Tabata, S; Tamate, H; Tanda, H; Tazuki, J, 1985)
"Aztreonam was well tolerated with no adverse effects."2.66Treatment of uncomplicated gonorrhoea with single dose aztreonam. ( Crooks, AJ; Evans, DT; Holman, RA; Jones, C; Price, SW, 1986)
"Aztreonam was well tolerated and there were no side-effects."2.66Single intramuscular injection of aztreonam in the treatment of uncomplicated gonorrhoea in women. ( Deighton, R; Mohanty, KC; Strachan, RG, 1987)
"Aztreonam appears to be an effective alternative to cephalosporins in the treatment of uncomplicated gonorrhoea, particularly when patients are suspected of being infected by strains with reduced susceptibility to ceftriaxone or are known to be allergic to penicillin."1.46Repurposing an old drug: aztreonam as a new treatment strategy for gonorrhoea. ( Calin, R; Davido, B; Dinh, A; Makhloufi, S; Salomon, J; Senard, O, 2017)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-199011 (64.71)18.7374
1990's1 (5.88)18.2507
2000's2 (11.76)29.6817
2010's1 (5.88)24.3611
2020's2 (11.76)2.80

Authors

AuthorsStudies
Barbee, LA2
Golden, MR2
Soge, OO1
Ocbamichael, N1
LeClair, A1
Davido, B1
Dinh, A1
Senard, O1
Calin, R1
Makhloufi, S1
Salomon, J1
Miller, LK1
Sanchez, PL1
Berg, SW1
Kerbs, SB1
Harrison, WO1
Okazaki, T1
Akasaka, S2
Muratani, T2
Yamada, Y2
Inatomi, H2
Takahashi, K2
Matsumoto, T2
Kobayashi, T1
Stöberl, C1
Poitschek, C1
Söltz-Szöts, J1
Spencer, RC1
Talbot, MD1
Evans, DT1
Crooks, AJ1
Jones, C1
Holman, RA1
Price, SW1
Tait, IB1
Winning, J1
Sleigh, JD1
Gottlieb, A1
Mills, J1
Mohanty, KC2
Deighton Fimls, R1
Strachan, RG2
Deighton, R1
Mulcahy, F1
Barr, K1
Lacy, C1
Lacey, R1
Henry, SA1
Bendush, CB1
Kumamoto, Y1
Sakai, S1
Tamate, H1
Gohro, T1
Inoke, T1
Tabata, S1
Tanda, H1
Kato, S1
Igawa, K1
Tazuki, J1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Aztreonam for Pharyngeal Gonorrhea: A Demonstration Study[NCT03867734]Phase 2/Phase 332 participants (Actual)Interventional2019-04-05Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Efficacy of 2 g Aztreonam for N. Gonorrhoeae at Anogenital Sites

Number of individuals with a negative N. gonorrhoeae culture at an anogenital site at test of cure among those who were N. gonorrhoeae culture positive at the respective anatomic site at the enrollment visit. (NCT03867734)
Timeframe: Test of Cure 4-7 days following treatment

InterventionParticipants (Count of Participants)
Efficacy of 2g Aztreonam for Urethral Gonorrhea9
Efficacy of 2g Aztreonam for Rectal Gonorrhea3

Tolerability of 2g Aztreonam IM

Subjects' self-report of injection related pain on a scale from 0 - 10 where 0 is no pain and 10 is the worst pain ever. (NCT03867734)
Timeframe: Immediately following injection

Interventionscore on a scale (Median)
2g Aztreonam2

Treatment Efficacy of Pharyngeal Gonorrhea as Defined as the Proportion of Study Participants With Positive Pharyngeal Gonorrhea Culture at of Enrollment Whose Test of Cure Pharyngeal Culture is Negative

Negative Test of Cure (i.e. Pharyngeal Gonorrhea Culture) after Treatment (NCT03867734)
Timeframe: 4-7 days following treatment

InterventionParticipants (Count of Participants)
Pharyngeal Gonorrhea -- Evaluable Population2

Side Effects of 2g Aztreonam IM

Subject's report of perceived side effects related to study drug based on responses to standard side effect questionnaire. (NCT03867734)
Timeframe: assessed immediately following injection and 4-7 days after injection

InterventionParticipants (Count of Participants)
reported having a HEADACHEreported having NAUSEA
2g Aztreonam61

Reviews

1 review available for aztreonam and Gonorrhea

ArticleYear
Aztreonam for Neisseria gonorrhoeae: a systematic review and meta-analysis.
    The Journal of antimicrobial chemotherapy, 2020, 07-01, Volume: 75, Issue:7

    Topics: Anti-Bacterial Agents; Aztreonam; Ceftriaxone; Gonorrhea; Humans; Neisseria gonorrhoeae

2020

Trials

7 trials available for aztreonam and Gonorrhea

ArticleYear
Effectiveness of aztreonam, a new monobactam antibiotic, against penicillin-resistant gonococci.
    The Journal of infectious diseases, 1983, Volume: 148, Issue:3

    Topics: Anti-Bacterial Agents; Aztreonam; Drug Evaluation; Gonorrhea; Humans; Male; Neisseria gonorrhoeae; P

1983
[Aztreonam, a new approach in the therapy of gonorrhea].
    Wiener klinische Wochenschrift, 1991, Volume: 103, Issue:9

    Topics: Aztreonam; Female; Gonorrhea; Humans; Male; Microbial Sensitivity Tests; Neisseria gonorrhoeae

1991
Treatment of uncomplicated gonorrhoea with single dose aztreonam.
    Genitourinary medicine, 1986, Volume: 62, Issue:5

    Topics: Adult; Aztreonam; Clinical Trials as Topic; Female; Gonorrhea; Humans; Injections, Intramuscular; Ma

1986
Effectiveness of aztreonam for the treatment of gonorrhea.
    Antimicrobial agents and chemotherapy, 1985, Volume: 27, Issue:2

    Topics: Adolescent; Adult; Anti-Bacterial Agents; Aztreonam; Clinical Trials as Topic; Female; Gonorrhea; Hu

1985
A comparative study of aztreonam and procaine penicillin/probenecid in the treatment of uncomplicated gonorrhoea.
    Scandinavian journal of infectious diseases, 1988, Volume: 20, Issue:1

    Topics: Aztreonam; Clinical Trials as Topic; Drug Therapy, Combination; Female; Gonorrhea; Humans; Male; Mic

1988
Single intramuscular injection of aztreonam in the treatment of uncomplicated gonorrhoea in women.
    Current medical research and opinion, 1987, Volume: 10, Issue:9

    Topics: Aztreonam; Drug Evaluation; Female; Gonorrhea; Humans; Injections, Intramuscular; Microbial Sensitiv

1987
Aztreonam: worldwide overview of the treatment of patients with gram-negative infections.
    The American journal of medicine, 1985, Feb-08, Volume: 78, Issue:2A

    Topics: Abdomen; Adult; Anti-Bacterial Agents; Arthritis, Infectious; Aztreonam; Bacterial Infections; Clini

1985

Other Studies

9 other studies available for aztreonam and Gonorrhea

ArticleYear
Single-Arm Open-Label Clinical Trial of Two Grams of Aztreonam for the Treatment of Neisseria gonorrhoeae.
    Antimicrobial agents and chemotherapy, 2020, 12-16, Volume: 65, Issue:1

    Topics: Anti-Bacterial Agents; Aztreonam; Ceftriaxone; Gonorrhea; Humans; Male; Neisseria gonorrhoeae; Ureth

2020
Repurposing an old drug: aztreonam as a new treatment strategy for gonorrhoea.
    The Journal of antimicrobial chemotherapy, 2017, 05-01, Volume: 72, Issue:5

    Topics: Adult; Anti-Bacterial Agents; Aztreonam; Drug Repositioning; Female; Gonorrhea; Humans; Male; Microb

2017
[Bacteriological and clinical evaluation of the effect of azthreonam on gonorrheal urethritis in man].
    The Japanese journal of antibiotics, 1984, Volume: 37, Issue:10

    Topics: Adult; Anti-Bacterial Agents; Aztreonam; Drug Evaluation; Drug Resistance, Microbial; Gonorrhea; Hum

1984
Emergence of cephem- and aztreonam-high-resistant Neisseria gonorrhoeae that does not produce beta-lactamase.
    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2001, Volume: 7, Issue:1

    Topics: Adult; Anti-Infective Agents; Aztreonam; Cefdinir; Ceftriaxone; Cephalosporins; Drug Resistance, Mic

2001
Outbreak of cefozopran (penicillin, oral cephems, and aztreonam)-resistant Neisseria gonorrhoeae in Japan.
    Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:12

    Topics: Adult; Anti-Bacterial Agents; Aztreonam; Cefozopran; Cephalosporins; Disease Outbreaks; DNA, Bacteri

2001
The use of aztreonam in the treatment of uncomplicated gonorrhoea.
    Current medical research and opinion, 1985, Volume: 9, Issue:9

    Topics: Aztreonam; Cefuroxime; Female; Gonorrhea; Humans; Injections, Intramuscular; Male; Microbial Sensiti

1985
Single dose aztreonam in treating gonorrhoea.
    Genitourinary medicine, 1987, Volume: 63, Issue:1

    Topics: Adolescent; Adult; Aged; Aztreonam; Female; Gonorrhea; Humans; Injections, Intramuscular; Male; Micr

1987
Lack of disturbance of the gut flora associated with the use of aztreonam for the treatment of gonorrhea.
    Chemioterapia : international journal of the Mediterranean Society of Chemotherapy, 1987, Volume: 6, Issue:2 Suppl

    Topics: Adolescent; Adult; Aztreonam; Drug Resistance, Microbial; Enterobacteriaceae; Female; Gonorrhea; Hum

1987
[Epidemiologic and therapeutic study on gonorrheal infections--one shot therapy by aztreonam].
    Hinyokika kiyo. Acta urologica Japonica, 1985, Volume: 31, Issue:11

    Topics: Adolescent; Adult; Age Factors; Aztreonam; Drug Evaluation; Female; Gonorrhea; Humans; Japan; Male;

1985