aztreonam and Endomyometritis studies

Aztreonam: A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms.
aztreonam : A synthetic monocyclic beta-lactam antibiotic (monobactam), used primarily to treat infections caused by Gram-negative bacteria. It inhibits mucopeptide synthesis in the bacterial cell wall, thereby blocking peptidoglycan crosslinking.

Endomyometritis: Inflammation of both the ENDOMETRIUM and the MYOMETRIUM, usually caused by infections after a CESAREAN SECTION.

Research Excerpts

Excerpt	Relevance	Reference
"Sixty-two patients who had postpartum endometritis were treated with clindamycin in combination with either aztreonam or the aminoglycoside gentamicin."	9.06	Comparison trial of clindamycin with aztreonam or gentamicin in the treatment of postpartum endometritis. ( Bollinger, M; Greenberg, RN; Ojile, JM; Reilly, PM; Weinandt, WJ; Wilson, KM, 1987)
"5 mg/kg intravenously every eight hours), each with clindamycin (600 mg intravenously every six hours), was performed in 119 patients with endometritis after cesarean section."	9.05	Aztreonam versus gentamicin, each with clindamycin, in the treatment of endometritis. ( Blanco, JD; Gibbs, RS; Lipscomb, KA; St Clair, PJ, 1985)
"Sixty-two patients who had postpartum endometritis were treated with clindamycin in combination with either aztreonam or the aminoglycoside gentamicin."	5.06	Comparison trial of clindamycin with aztreonam or gentamicin in the treatment of postpartum endometritis. ( Bollinger, M; Greenberg, RN; Ojile, JM; Reilly, PM; Weinandt, WJ; Wilson, KM, 1987)
"5 mg/kg intravenously every eight hours), each with clindamycin (600 mg intravenously every six hours), was performed in 119 patients with endometritis after cesarean section."	5.05	Aztreonam versus gentamicin, each with clindamycin, in the treatment of endometritis. ( Blanco, JD; Gibbs, RS; Lipscomb, KA; St Clair, PJ, 1985)
"Endomyometritis is the most common complication associated with cesarean delivery."	3.76	Pathophysiology and management of postcesarean endomyometritis. ( Duff, P, 1986)
"Aztreonam, a new monobactam antibiotic with specific gram-negative aerobic activity, was used in combination with clindamycin in the treatment of 40 women with pelvic infection, including post-partum endometritis, pelvic inflammatory disease, and post-hysterectomy pelvic cellulitis."	3.67	Aztreonam plus clindamycin as therapy for pelvic infections in women. ( Aldridge, KE; Cole, C; Crapanzano, JC; Pastorek, JG, 1985)

Research

Studies (4)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Duration of Hospital Stay After Cesarean Delivery

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (100.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Greenberg, RN	1
Reilly, PM	1
Weinandt, WJ	1
Wilson, KM	1
Bollinger, M	1
Ojile, JM	1
Duff, P	1
Gibbs, RS	1
Blanco, JD	1
Lipscomb, KA	1
St Clair, PJ	1
Pastorek, JG	1
Cole, C	1
Aldridge, KE	1
Crapanzano, JC	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Treatment Utility of Postpartum Antibiotics in Chorioamnionitis[NCT01585129]	Phase 4	80 participants (Actual)	Interventional	2010-09-30	Terminated (stopped due to Futility in patient enrollment)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

This is the duration of hospital stay (in days) after their cesarean delivery. (NCT01585129)
Timeframe: Up to 7 Days

Number of Paricipants With Endometritis

Intervention	days (Mean)
Postpartum Antibiotics	4
No Postpartum Antibiotics	4

Endometritis is defined as uterine infection and is diagnosed by maternal temp > 38.0C on two occasions over a 4 hour period or any temp > 39.0C after delivery > 12 hours after delivery. Endometritis will be managed per currently accepted endometritis protocol - (Amp 2 gQ6, Gentamicin 5 mg/kg q24, Clindamycin 900 mg q8). (NCT01585129)
Timeframe: 7 days post-partum

Number of Participants With Infection-related Complications

Intervention	Participants (Count of Participants)
Postpartum Antibiotics	4
No Postpartum Antibiotics	3

Infection related complications will include common complications attributed to infections there are not the primary outcome (endometritis). This will include infections of the wound and pelvic abscesses. (NCT01585129)
Timeframe: 7 days post-partum

Article	Year
Comparison trial of clindamycin with aztreonam or gentamicin in the treatment of postpartum endometritis. Clinical therapeutics, 1987, Volume: 10, Issue:1 Topics: Adolescent; Adult; Aztreonam; Clindamycin; Clinical Trials as Topic; Drug Therapy, Combination; Endo	1987
Pathophysiology and management of postcesarean endomyometritis. Obstetrics and gynecology, 1986, Volume: 67, Issue:2 Topics: Adult; Anti-Bacterial Agents; Aztreonam; Bacterial Infections; Cephalosporins; Cesarean Section; Cli	1986
Aztreonam versus gentamicin, each with clindamycin, in the treatment of endometritis. Obstetrics and gynecology, 1985, Volume: 65, Issue:6 Topics: Adult; Anti-Bacterial Agents; Aztreonam; Cesarean Section; Clindamycin; Clinical Trials as Topic; Dr	1985

aztreonam and Endomyometritis