azoxymethane has been researched along with Disease Models, Animal in 401 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (1.75) | 18.7374 |
| 1990's | 13 (3.24) | 18.2507 |
| 2000's | 74 (18.45) | 29.6817 |
| 2010's | 207 (51.62) | 24.3611 |
| 2020's | 100 (24.94) | 2.80 |
| Authors | Studies |
|---|---|
| Chan, AWH; Coker, OO; Lau, HCH; Li, C; Lin, Y; Sung, JJY; Szeto, CH; Wei, H; Yang, J; Yu, J; Zhou, Y | 1 |
| Gong, W; Gu, G; Hong, Z; Liu, J; Liu, P; Ren, H; Ren, J; Wang, G; Wu, X; Zhao, F; Zhao, Y; Zheng, T | 1 |
| Hashimoto, S; Kojima, H; Kubota, A; Maeda, H; Miyashita, K; Mutoh, M; Ohta, T; Ono, S; Tanaka, T; Terasaki, M | 1 |
| Donthi, D; Hong, H; Lertpiriyapong, K; Marie, MA; Sanderlin, EJ; Satturwar, S; Yang, LV | 1 |
| Canter, JA; Cao, L; Carlson, BA; Davis, CD; Ernst, SE; Gladyshev, VN; Grysczyk, L; Hatfield, DL; Peters, KM; Thielman, NRJ; Tsuji, PA; Udofe, P; Yu, Y | 1 |
| He, L; Li, W; Ma, Y; Sun, P; Wang, H; Zhang, X; Zhao, X | 1 |
| Chen, GQ; Chen, J; Li, Z; Liu, G; Wu, F; Zhang, S; Zhang, Y | 1 |
| Bou-Dargham, M; Chen, YH; Etwebi, Z; Goldsmith, JR; Hood, R; Lengner, C; Li, M; Liu, S; Lou, Y; Spitofsky, N; Sun, H; Tian, Y | 1 |
| Li, JC; Rui, XL; Shao, FP; Xu, L; Yang, Y; Yin, DK; Zhang, MM | 1 |
| Bobula, B; Orzeł-Gajowik, K; Popek, M; Zielińska, M | 1 |
| Birod, K; Brachtendorf, S; El-Hindi, K; Grösch, S; Hartel, JC; Merz, N; Oertel, S; Schäufele, TJ; Schiffmann, S; Scholich, K; Thomas, D; Trautmann, S; Ulshöfer, T; Utermöhlen, O; Weigert, A | 1 |
| Deng, J; Han, L; Li, Y; Shi, J; Wang, H; Yan, Y; Yuan, X; Zhang, H; Zhao, H; Zhao, L; Zhao, Y; Zou, F | 1 |
| Gan, Y; Gao, C; Huang, B; Liu, Y; Pan, D; Tang, Z | 1 |
| Eferl, R; Gushchina, V; Kallay, E; Kupper, N; Manhardt, T; Mesteri, I; Moritsch, S; Müller, C; Piatek, K; Salzmann, M; Schepelmann, M; Vlasaty, A | 1 |
| Jiang, S; Ma, F; Mu, G; Qian, F; Song, Y; Sun, M; Tuo, Y; Wang, A | 1 |
| Chen, K; Gao, Z; Jia, H; Shi, Y; Wang, Z; Yuan, Y; Yue, T; Zeng, X | 1 |
| Cai, B; Chen, H; Guo, Y; Wang, X; Yao, Q; Ye, C; Zhang, F; Zhang, J; Zhang, Z | 1 |
| Kim, M; Kim, Y; Lee, S; Moon, S | 1 |
| Chang, J; Geng, Z; Hao, X; Liu, J; Tan, X; Wang, Z; Yan, S | 1 |
| Kamakura, Y; Kawakami, S; Kojima, H; Kubota, A; Maeda, H; Miyashita, K; Murase, W; Mutoh, M; Ohta, T; Tanaka, T; Terasaki, M | 1 |
| Chen, Q; Chu, Y; Dai, Y; Fang, Y; Lv, C; Wei, Z; Xia, Y; Yun, X; Zhang, Q; Zhu, Y | 1 |
| Aladhami, A; Bader, JE; Chatzistamou, I; Cunningham, P; Enos, RT; Helms, H; Martinez-Muñiz, G; Noneman, MT; Patton, E; Shin, HK; Sumal, A; Unger, C; Velázquez, KT | 1 |
| Dong, S; Ismael, M; Lü, X; Shan, Y; Wang, T; Wang, X; Zheng, J | 1 |
| Choi, SI; Jang, JY; Kim, N; Lee, HN; Nam, RH; Song, CH | 1 |
| Chen, Q; Fu, J; Han, H; Lin, H; Lu, G; Ma, X; Qi, J; Wen, Z; Yang, M; Yang, X; Yang, Y; Yin, T | 1 |
| Jiang, Q; Jones-Hall, Y; Nakatsu, C; Zhao, Y | 1 |
| Chen, IY; Hu, ML; Huang, WT; Lian, WS; Wang, FS; Yang, CH; Yang, JW; Yang, MY | 1 |
| Ajayi, BO; Ajeigbe, OF; Anyebe, DA; Farombi, EO; Maruf, OR; Opafunso, IT | 1 |
| Archer, A; Birgersson, M; Hases, L; Indukuri, R; Williams, C | 1 |
| Chang, Y; Chen, H; Kang, J; Liang, X; Sun, M; Xiao, T; Zhang, J | 1 |
| Hong, Y; Jia, ML; Li, YT; Liu, XM; Liu, ZQ; Yan, PK; Zhu, WT | 1 |
| Baker, K; Cotter, PD; Cronin, P; Gahan, CGM; Houston, A; Hyland, NP; Joyce, SA; Keane, JM; Melgar, S; Walsh, CJ | 1 |
| Ando, Y; Aoi, M; Fukui, T; Horitani, S; Matsumoto, Y; Naganuma, M; Okazaki, K; Tanaka, H; Tomiyama, T; Tsuneyama, K; Uragami, T | 1 |
| Blecker, C; Fan, X; Guo, H; Qin, P; Ren, G; Richel, A; Teng, C; Yang, X; Zhang, L | 1 |
| Bian, ZL; Chen, BQ; Chen, L; Chen, WJ; Cheng, TC; Feng, N; Ju, LL; Li, M; Liu, Y; Liu, YC; Liu, ZX; Luo, LL; Shao, JG; Wang, Y | 1 |
| Huang, XH; Jiang, B; Ni, M; Wang, L; Xu, YY; Zhang, QQ; Zhang, R; Zhang, YQ; Zhao, Q | 1 |
| Fan, RJ; Fang, MD; Ren, J; Tu, LL; Yao, WX; Zhang, YM; Zuo, BW | 1 |
| Chen, Y; Kang, C; Li, J; Liu, Z; Zhang, Q; Zhu, W | 1 |
| Arcos, M; Liu, Z; Martin, DR; Xue, X | 1 |
| Du, M; Tian, Q; Wang, H; Xu, Z; Zhu, MJ | 1 |
| An, SY; Kim, J; Kim, SW; Lee, DB; Pyo, SS; Yoon, DW | 1 |
| Kettawan, A; Prombutara, P; Rungruang, T; Tajasuwan, L; Wunjuntuk, K | 1 |
| Chen, C; El-Nezami, H; Ismaiah, MJ; Leung, HKM; Lo, EKK; Zhang, F | 1 |
| Feng, YL; Jia, J; Luo, YY; Ouyang, H; Wan, MQ; Xie, XX; Yang, X; Yu, J | 1 |
| Kang, X; Kwong, TNY; Lam, TYT; Lin, Y; Liu, C; Ng, SK; Ni, Y; Sung, JJY; Wei, H; Wong, SH; Wu, WKK; Yu, J; Zhou, Y | 1 |
| Bullard, BM; Cardaci, TD; Fan, D; Hofseth, LJ; Huss, AR; McDonald, SJ; Murphy, EA; VanderVeen, BN | 1 |
| Fukui, T; Honzawa, Y; Horitani, S; Matsumoto, Y; Naganuma, M; Okazaki, K; Suzuki, R; Tahara, T; Tanimura, Y; Tomiyama, T | 1 |
| Duan, J; Duan, W; Gao, Q; Li, J; Mao, T; Wang, M; Yan, J | 1 |
| Al-Omari, M; Al-Omari, T; Al-Qauod, K; Batainah, N; Janciauskiene, S; Olejnicka, B | 1 |
| Chen, Y; Li, P; Liang, J; Luo, X; Wang, Q; Xie, X; Yang, C; Zhang, M; Zhou, L | 1 |
| Abreu, AC; Aydos, RD; Fagundes, LS; Gonçalves, AF; Neves, MB; Ramalho, RT; Silva Junior, UND; Takita, LC | 1 |
| Dzhalilova, D; Fokichev, N; Makarova, O; Zolotova, N | 1 |
| Chen, X; Deng, Y; He, F; Huang, X; Tian, L; Wang, M; Yang, W; Yin, W; Zhou, H | 1 |
| Arias-Romero, LE; Callejas, BE; Chirino, YI; Delgado-Buenrostro, NL; León-Cabrera, SA; Martínez-Saucedo, D; Mendoza-Rodríguez, MG; Pérez-Plasencia, C; Reyes-Martínez, S; Rodríguez-Sosa, M; Sánchez-Barrera, CA; Terrazas, LI; Vaca-Paniagua, F; Villamar-Cruz, O | 1 |
| Djurhuus, D; Nielsen, B; Olsen, J; Pedersen, AE; Sadowska, Z; Tougaard, P; Yassin, M | 1 |
| Chen, X; Decker, EA; Kim, D; Ma, Q; Park, Y; Qi, W; Sanidad, KZ; Yang, R; Zhang, G; Zhang, J | 1 |
| El-Daly, SM; El-Khayat, Z; Hussein, J; Omara, EA; Youness, ER | 1 |
| Li, Y; Liu, G; Liu, J; Ma, Y; Pan, Z; She, J; Wei, Q; Xia, H; Zhang, M; Zhang, RX | 1 |
| Aranda-Vargas, PJ; Chávez-Servín, JL; de la Torre-Carbot, K; Ferríz-Martínez, RA; García-Gasca, T; González-Reyes, A; Kuri-García, A; Mejía, C; Moreno Celis, U; Saldaña Gutiérrez, C | 1 |
| Gao, Y; Hammad, A; Namani, A; Shi, HF; Tang, X; Zheng, ZH | 1 |
| Li, J; Li, W; Ma, Y; Qian, J; Wang, C; Wang, H; Yang, H; Zhang, X; Zhao, X | 1 |
| Chen, X; Han, W; Li, Y; Shi, L; Wan, J; Wang, H; Xie, B | 1 |
| Chen, N; Cheng, L; Dai, L; Deng, H; Dong, Z; Fang, C; Fu, J; Ji, Y; Li, J; Liu, Y; Shi, G; Su, X; Wang, H; Wang, W; Yang, Y; Yu, Y; Zhang, H; Zhang, S | 1 |
| Eun, CS; Han, DS; Jo, SV; Lee, AR; Lee, JG; Park, CH | 1 |
| Carney, B; Coffey, RJ; Houghton, JL; Jae Huh, W; McKinley, ET; Niitsu, H | 1 |
| Aggarwal, A; Baumgartner, M; Gasche, C; Gröschel, C; Heiden, D; Kallay, E; Karuthedom George, S; Lang, M; Manhardt, T; Marculescu, R; Mesteri, I; Prinz-Wohlgenannt, M; Schepelmann, M; Tennakoon, S; Trawnicek, L | 1 |
| Angel, JM; Bissahoyo, AC; Demant, P; Elliott, RW; Lee, D; McMillan, L; Pardo-Manuel de Villena, F; Pearsall, RS; Threadgill, DW; Xie, Y; Yang, L | 1 |
| Allred, CD; Allred, KF; Callaway, ES; Chapkin, RS; Davidson, LA; DeLuca, JAA; Garcia-Villatoro, EL; Hensel, ME; Ivanov, I; Jayaraman, A; Menon, R; Safe, SH | 1 |
| Chartier, LC; Hebart, ML; Howarth, GS; Mashtoub, S; Whittaker, AL | 1 |
| Benninghoff, AD; Hintze, KJ; Hunter, AH; Monsanto, SP; Pestka, JJ; Phatak, S; Rodriguez, DM; Ward, RE; Wettere, AJV | 1 |
| Huh, TG; Jeong, BJ; Jeong, JS; Kim, HY; Lee, JS; Park, KY; Song, JL | 1 |
| Ibuka, T; Kato, J; Kubota, M; Mizutani, T; Sakai, H; Shimizu, M; Shirakami, Y | 1 |
| Lin, L; Lin, Y; Qu, S; Wang, D; Zhao, H | 1 |
| Qiao, PF; Yao, L; Zeng, ZL | 1 |
| Bian, X; Fang, D; Jiang, X; Li, L; Li, Y; Lu, Y; Lv, L; Wang, K; Wang, Q; Wu, J; Wu, W; Xie, J; Yang, L; Ye, J | 1 |
| Bian, X; Chan, AWH; Chan, FKL; Coker, OO; El-Omar, E; Nakatsu, G; Sung, JJY; Wei, H; Wu, J; Yu, J; Zhao, L; Zhao, R; Zhou, Y | 1 |
| Lin, R; Liu, C; Piao, M; Song, Y | 1 |
| Kim, HJ; Lee, HW; Oh, JH; Park, BM; Roh, JI | 1 |
| Deng, T; Liu, M; Wan, X; Xie, W | 1 |
| Hu, Y; Ji, X; Li, Z; Liu, S; Lv, H; Ma, H; Wang, J; Wang, S; Wang, X; Wang, Y; Xu, Y; Zhang, B | 1 |
| Huang, X; Jiang, Z; Li, H; Li, L; Sun, L; Wang, T; Wang, X; Xing, X; Zhang, L; Zhang, X | 1 |
| Bai, R; Boardman, LA; Bode, AM; Chang, X; Chen, H; Dong, Z; Lim, DY; Ma, WY; Ryu, J; Wang, K; Wang, Q; Wang, T; Yao, K; Zhang, T | 1 |
| Gao, WQ; Gui, L; Ji, L; Liu, M; Ma, B; Wang, C; Wang, Y; Yan, J; Yin, P | 1 |
| Bagamery, G; Baranyai, Z; Ferenczi, S; Fuder, E; Hegedus, N; Horvath, K; Josa, V; Juhasz, B; Kovacs, T; Kuti, D; Mathe, D; Szalai, R; Veres, DS; Winkler, Z; Zrubka, Z | 1 |
| Chen, TH; Chen, YH; Chiu, CC; Chuang, HL; Huang, WC; Hung, SW; Lee, YP; Lin, TJ; Wang, YC | 1 |
| Kojima, H; Kubota, A; Maeda, H; Miyashita, K; Mutoh, M; Ogasa, S; Sano, T; Tanaka, T; Terasaki, M; Uehara, O | 1 |
| Chartier, LC; Howarth, GS; Mashtoub, S; Trinder, D | 1 |
| Amini, N; Andreatos, N; Angelou, A; Antoniou, E; Buettner, S; Kamphues, C; Margonis, GA; Munir, M; Papalois, AE; Pikouli, A; Pikoulis, E; Pulvirenti, A; Sarantis, P; Theocharis, S; Theodoropoulos, G; Wang, J; Zografos, GC | 1 |
| He, C; Hu, M; Li, P; Li, Y; Liu, Q; Liu, S; Shen, J; Sun, Y; Xiao, P; Yang, C; Zhang, Z | 1 |
| Horiguchi, H; Kadomatsu, T; Miyata, K; Morinaga, J; Moroishi, T; Oike, Y; Sato, M; Terada, K; Torigoe, D | 1 |
| Bian, S; Liao, X; Wan, H; Wang, W | 1 |
| Abreu, MT; Brito, N; Burgueño, JF; Conner, GE; Davies, JM; Dheer, R; Diaz, S; Fernández, E; Fernández, I; Fritsch, J; González, EE; Hazime, H; Landau, KS; Phillips, MC; Pignac-Kobinger, J; Santander, AM; Santaolalla, R | 1 |
| Fernández, J; Ferreira-Lazarte, A; Gallego-Lobillo, P; Lombó, F; Moreno, FJ; Villamiel, M; Villar, CJ | 1 |
| Boonsanay, V; Brabletz, T; Greten, FR; Heichler, C; Neufert, C; Neurath, MF; Scheibe, K | 1 |
| Barrett, CW; Burk, RF; Chen, X; Denson, LA; Haberman, Y; Hendren, JR; Hill, KE; Hyams, JS; Keating, CE; Marsh, BJ; Motley, AK; Pilat, JM; Reddy, VK; Rosen, MJ; Shi, C; Short, SP; Washington, MK; Williams, CS; Wilson, KT; Zemper, AE | 1 |
| Epifano, F; Fiorito, S; Genovese, S; Ibuka, T; Ideta, T; Kubota, M; Maruta, A; Miyazaki, T; Mizutani, T; Sakai, H; Shimizu, M; Shirakami, Y; Taddeo, VA; Tanaka, T | 1 |
| Chen, S; Chen, Y; Gao, J; Hou, S; Hu, J; Liang, J; Lin, J; Lu, Y; Wang, B; Yuan, X | 1 |
| Basu, S; Dannenberg, AJ; Ito, N; Makino, T; Montrose, DC | 1 |
| Hiramoto, K; Kawanishi, S; Ma, N; Murata, M; Ohnishi, S; Wang, G; Yoshikawa, N | 1 |
| He, JM; Hu, JN; Liang, X | 1 |
| Aparna, JS; Athira, SR; Babu, A; Harikumar, KB; James, S; Kumar, SS; Lankadasari, MB; Mohammed, S; Namitha, NN; Paul, AM; Reshmi, G; Vijayan, Y | 1 |
| Bailey, B; Dasgupta, S; DeBoever, C; Faustin, B; Grieves, J; Liu, H; Murphy, C; Wyrick, C | 1 |
| Fan, Y; Huang, MQ; Jia, XK; Lan, ML; Li, XY; Wu, SS; Xu, SH; Xu, W; Zhu, HC | 1 |
| Abba, MC; Blidner, AG; Cagnoni, AJ; Croci, DO; Cutine, AM; Gatto, SG; Giribaldi, ML; Mariño, KV; Morales, RM; Rabinovich, GA; Salatino, M | 1 |
| Esa, NM; Ishak, NIM; Madzuki, IN; Mohamed, S; Mustapha, NM | 1 |
| Chen, L; Cheung, S; Feng, Y; He, W; Li, Z; McDonald, F; Tao, L; Wang, G; Yang, J; Yang, M; Zhang, Y; Zhong, X | 1 |
| Elshaer, M; Hammad, A; Namani, A; Tang, X; Wang, XJ; Zheng, ZH | 1 |
| Ahn, JY; An, BC; Choi, O; Chung, MJ; Chung, Y; Kim, JF; Kim, TY; Kwon, SK; Park, HJ; Ryu, Y; Yoon, J; Yoon, YS | 1 |
| Álvarez-González, I; García-Cordero, JM; Jiménez-Martínez, C; Madrigal-Bujaidar, E; Madrigal-Santillán, E; Martínez-Palma, NY; Morales-González, JA; Paniagua-Pérez, R | 1 |
| Chen, L; Liu, M; Meng, X; Ren, S; Sun, Q; Xu, H; Yang, H; Zeng, S; Zhao, H | 1 |
| Liu, B; Liu, Y; Lü, X; Shan, Y; Wang, G; Wang, P; Wang, T; Wang, X; Yi, Y; Zhang, L; Zhou, Y | 1 |
| Ho, CT; Lee, PS; Nagabhushanam, K; Pan, MH | 1 |
| Ayala-Peña, S; Ballista-Hernández, J; Climent, C; Martínez-Ferrer, M; Rodríguez-Muñoz, A; Sánchez-Vázquez, MM; Torres, C; Torres-Ramos, CA; Vélez, R | 1 |
| Bellamkonda, K; Chandrashekar, NK; Douglas, D; Osman, J; Savari, S; Sjölander, A | 1 |
| Hayashi, SM; Kangawa, Y; Kataoka, A; Koyama, N; Ohsumi, T; Shibutani, M; Tanaka, T; Yoshida, T | 1 |
| Dai, X; Gui, G; Li, K; Liu, J; Xiao, Y; Yang, H | 1 |
| Barton, JK; Chandra, S; Gerner, EW; Nymeyer, AC; Rice, PF | 1 |
| He, L; Luan, Z; Lv, H; Qian, J; Tan, B; Wang, H; Xin, Y; Yang, H; Yu, S; Zhao, X; Zhou, W; Zhou, Y | 1 |
| Chan, FKL; Han, J; Kwong, TNY; Nakatsu, G; Sung, JJY; Tsoi, H; Wei, H; Wong, SH; Wu, WKK; Xiao, X; Xu, W; Yu, J; Zeng, B; Zhang, X; Zhao, L | 1 |
| Alfwuaires, M; Alzahrani, AM; Bani Ismail, M; Hanieh, H; Ibrahim, HM; Mohafez, O; Shehata, T | 1 |
| Bader, JE; Carson, JA; Carson, MS; Chatzistamou, I; Davis, JM; Enos, RT; Murphy, EA; Nagarkatti, M; Nagarkatti, PS; Robinson, CM; Velázquez, KT | 1 |
| Hou, G; Liu, S; Lou, X; Wang, Y | 1 |
| García-Sanmartín, J; Martínez, A; Martínez-Herrero, S; Narro-Íñiguez, J; Ochoa-Callejero, L; Rubio-Mediavilla, S | 1 |
| Lin, JA; Wu, CH; Yen, GC | 1 |
| Chen, P; Hou, Z; Jia, H; Shen, B; Song, H; Sun, Y; Wang, W | 1 |
| Cai, YK; Chen, J; Chen, WJ; Hao, Z; Lv, Y; Wang, HP; Wang, X; Ye, T; Zhao, JY | 1 |
| Campos-Vega, R; Cuellar-Nuñez, ML; Gallegos-Corona, MA; González de Mejía, E; Loarca-Piña, G; Luzardo-Ocampo, I | 1 |
| Cheng, D; Fang, M; Gao, L; Gaspar, JM; Guo, Y; Hart, RP; Kong, AN; Li, W; Sargsyan, D; Su, ZY; Verzi, MP; Wang, C; Wu, R; Yin, R; Zhang, C | 1 |
| Cui, SX; Qu, XJ; Wang, F; Zhang, YS | 1 |
| Mahmudah, N; Purnomosari, D; Widyarini, S | 1 |
| Gong, D; Hu, JL; Liu, LQ; Nie, SP; Shen, MY; Xie, MY; Yu, Q | 1 |
| Callaway, E; Chapkin, RS; Goldsby, J; Ivanov, I; McLean, MW; Triff, K | 1 |
| Currey, N; Dahlstrom, JE; Daniel, JJ; Kohonen-Corish, MRJ; Mladenova, DN | 1 |
| Brambilla, SR; Camargo, JA; Carvalheira, JBC; Mendes, MCS; Paulino, DS; Persinoti, GF | 1 |
| Jia, W; Luo, Y; Niu, W; Wang, J; Wu, Z; Yang, M; Zhang, H; Zhang, X | 1 |
| Andreatos, N; Angelou, A; Antoniou, E; Damaskos, C; Garmpis, N; Margonis, GA; Papalois, A; Theocharis, S; Theodoropoulos, G; Xiao, W; Yuan, C; Zacharioudaki, A; Zografos, G | 1 |
| DeMorrow, S; Frampton, G; Grant, S; Jaeger, V; Kain, J; McMillin, M; Petrescu, AD; Williams, E | 1 |
| Chen, Q; Deng, S; Dong, Y; Fan, H; Hu, J; Liu, X; Liu, Y; Nan, Z; Shou, Z; Tang, Q; Wang, H; Wu, H; Xu, M; Yang, J; Zhang, L; Zuo, D | 1 |
| Bravou, V; Champeris Tsaniras, S; Giannou, AD; Gorgoulis, VG; Karousi, F; Lalioti, ME; Lygerou, Z; Nikou, S; Pateras, IS; Patmanidi, AL; Petropoulos, M; Stathopoulos, GT; Taraviras, S; Tserou, P; Villiou, M | 1 |
| Chastre, E; Jordan, P; Kotelevets, L; Lehy, T; Mamadou, G; Walker, F | 1 |
| Chang, YY; Huang, WJ; Jeng, YM; Jhuang, YL; Yang, CY; Yu, IS; Yu, LC | 1 |
| Kim, JS; Kim, N; Lee, DH; Lee, HN; Lee, SM; Na, HY; Nam, RH; Park, JH; Shin, E; Sohn, SH; Son, HJ; Song, CH; Surh, YJ | 1 |
| Barone, M; Di Leo, A; Giorgio, F; Girardi, B; Iannone, A; Ierardi, E; Losurdo, G; Pricci, M; Principi, M | 1 |
| Almoghrabi, A; Backman, V; Bissonnette, M; Dougherty, U; Eshein, A; Gomes, A; Hart, J; Konda, V; Pabla, B; Roy, HK; Ruderman, S; Singh, A; Valuckaite, V | 1 |
| Booth, CJ; D'Souza, SS; Kartchner, BJ; Lee, EC; Malizia, RA; O'Connor, W; Sharp, SP; Stain, SC; Walrath, T | 1 |
| Chu, Y; Gu, J; Huang, E; Li, Y; Liang, Y; Liu, J; Liu, R; Lu, Z; Wang, L; Wang, Z; Yu, H; Zhang, D; Zhang, H | 1 |
| Cao, Q; Chen, M; Chen, T; Ji, W; Peng, S; Qiu, Y; Que, B; Yuan, G; Zhang, H | 1 |
| Álvarez-González, I; Baltiérrez-Hoyos, R; Dávila-Ortiz, G; Garduño-Siciliano, L; Jiménez Martínez, C; León-Espinosa, EB; Madrigal-Bujaidar, E; Sánchez-Chino, XM; Vásquez-Garzón, VR | 1 |
| Balboa, MA; Balsinde, J; Cubero, Á; García-Rostán, G; Győrffy, B; Lordén, G; Meana, C; Orduña, A; Peña, L | 1 |
| Masuda, J; Seko, T; Umemura, C; Yamashita, M; Yamashita, Y; Yamauchi, K; Yokozawa, M | 1 |
| Aleksandersen, M; Berntsen, HF; Hansen, KEA; Johanson, SM; Paulsen, JE; Ropstad, E; Steppeler, C; Sødring, M; Zimmer, KE; Østby, GC | 1 |
| Al-Attabi, Z; Al-Malky, RN; Al-Maskari, SNM; Al-Ruqaishi, BRS; Ali, A; Deth, RC; Dong, J; Guizani, N; Padmanabhan, S; Rahman, MS; Taranikanti, V; Waly, MI | 1 |
| Kim, N; Lee, DH; Lee, SM; Na, HY; Nam, RH; Sohn, SH; Song, CH; Surh, YJ | 1 |
| Arruda, SF; Campos, NA; da Cunha, MSB | 1 |
| Asami, Y; Hattori, N; Imai, T; Ishida, T; Kimura, K; Kobayashi, K; Mori, A; Mori, T; Niwa, T; Ushijima, T | 1 |
| Chen, S; Jing, X; Li, M; Liu, H; Liu, Y; Sun, B; Sun, T; Tian, Y; Wang, H; Yang, C; Zhang, Q; Zhao, J; Zhao, Y; Zong, S | 1 |
| Hwang, S; Khalmuratova, R; Kim, JH; Kim, YS; Koh, SJ; Lee, GY; Lee, M; Park, JW; Shin, HW; Yoon, DW | 1 |
| Han, W; Li, W; Lv, X; Wang, H; Zhao, X | 1 |
| Arthur, JC; Rothemich, A | 1 |
| Bader, JE; Carson, JA; Carson, M; Chatzistamou, I; Enos, RT; Kubinak, JL; Murphy, EA; Nagarkatti, M; Pena, MM; Sougiannis, AT; VanderVeen, BN; Velazquez, KT; Walla, M | 1 |
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| Fujii, G; Komiya, M; Mutoh, M; Nakano, K; Takahashi, M; Takasu, S; Teraoka, N; Ueno, T; Wakabayashi, K; Yamamoto, M; Yanaka, A | 1 |
| Dionne, S; Elimrani, I; Levy, E; Qureshi, IA; Roy, MJ; Sarma, DR; Seidman, EG | 1 |
| Butler, SM; Jeffery, EH; Jung, SH; Lee, EH; Nho, CW; Pan, CH; Wallig, MA | 1 |
| Itoh, M; Kawamori, T; Kitamura, T; Matsuura, M; Noda, T; Sugimura, T; Uchiya, N; Wakabayashi, K | 1 |
| Chawan, CB; Rao, DR; Shackelford, L; Verghese, M | 1 |
| Chawan, CB; Rao, DR; Shackelford, L; Verghese, M; Williams, LL | 1 |
| Bissonnette, M; Brasitus, T; Hart, J; Nguyen, L; Sitrin, MD; Stoiber, D; Wali, RK | 1 |
| Bissonnette, M; Brasitus, T; Cohen, G; Hart, J; Joseph, L; Khare, S; Nguyen, L; Ramaswamy, A; Sitrin, M; Tretiakova, M; Wali, RK; Wang, J; Wen, M | 1 |
| Burnouf, D; Delincee, H; Gosse, F; Hartwig, A; Marchioni, E; Miesch, M; Raul, F; Werner, D | 1 |
| Bruce, WR | 1 |
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| Fields, AP; Gustafson, WC; Murray, NR | 1 |
| Akedo, H; Baba, M; Higashino, K; Iishi, H; Mukai, M; Tatsuta, M; Yano, H | 1 |
| Kohno, H; Mori, H; Sugie, S; Suzuki, R; Tanaka, T; Yamada, Y | 1 |
| Gonzalez, FJ; Harman, FS; Marin, HE; Nicol, CJ; Peters, JM; Ward, JM | 1 |
| Reddy, BS | 1 |
| Biswas, S; Chytil, A; Gautam, S; Gorska, AE; Grady, WM; Moses, HL; Romero-Gallo, J; Washington, K; Wirth, PS | 1 |
| Patlolla, JM; Raju, J; Rao, CV; Swamy, MV | 1 |
| Fujita, K; Iigo, M; Matsuda, E; Sekine, K; Tsuda, H | 1 |
| Belinsky, GS; Blumberg, JB; Guda, K; Huang, X; Ilsley, JN; Milbury, PE; Roberts, LJ; Rosenberg, DW; Stevens, RG; Zhang, Q | 1 |
| Agger, R; Diederichsen, A; Hokland, M; Kobaek-Larsen, M; Nissen, I; Ritskes-Hoitinga, J; Zeuthen, J | 1 |
| Caderni, G; Pietro Femia, A; Rechkemmer, G; Roller, M; Watzl, B | 1 |
| Hart, J; Karolski, WJ; Ratashak, A; Roy, HK; Smyrk, TC; Wali, RK | 1 |
| Auwerx, J; Dubuquoy, L; Fayard, E; Geboes, K; Haby, C; Mebis, J; Schoonjans, K; Wendling, O | 1 |
| Kohno, H; Sugie, S; Suzuki, R; Tanaka, T | 1 |
| Davenport, DM; Muga, SJ; Volate, SR; Wargovich, MJ | 1 |
| Backman, V; Goldberg, MJ; Kim, YL; Koetsier, JL; Kunte, DP; Liu, Y; Roy, HK; Turzhitsky, V; Wali, RK | 1 |
| Becker, C; Fantini, MC; Galle, PR; Kiesslich, R; Lehr, HA; Neurath, MF; Nikolaev, A; Wirtz, S | 1 |
| Amann, V; Bissahoyo, A; Godfrey, VL; Hanlon, K; Hicks, D; Pearsall, RS; Threadgill, DW | 1 |
| Bak, AW; Devchand, PR; Wallace, JL; Zamuner, SR | 1 |
| Backman, V; Goldberg, MJ; Horwitz, J; Kim, YL; Liu, Y; Roy, HK; Turzhitsky, V; Wali, RK | 1 |
| Drenth, JP; Laverman, P; Nagengast, FM; Oyen, WJ; van Kouwen, MC; van Krieken, JH | 1 |
| Beauchemin, N; Jothy, S; Leung, N; Marcus, V; Olson, M; Turbide, C | 1 |
| Hirano, S; Mutoh, M; Niho, N; Nukaya, H; Sakano, K; Sugimura, T; Takahashi, M; Wakabayashi, K | 1 |
| Au, A; Birt, D; Koehler, K; Li, B; Roy, H; Wang, W | 1 |
| Dragsted, LO; Jacobsen, H; Lindecrona, RH; Meyer, O; Poulsen, M; Ravn-Haren, G | 1 |
| Fujimoto, K; Fujise, T; Iwakiri, R; Kakimoto, T; Ootani, A; Sakata, Y; Shiraishi, R; Tsunada, S; Wu, B | 1 |
| Bissonnette, M; Cerda, S; Cohen, G; Dougherty, U; Fichera, A; Gong, C; Hart, J; Jagadeeswaran, S; Joseph, L; Khare, S; Little, N; Mustafi, R; Sehdev, A; Tallerico, M; Tretiakova, M; Turner, JR; Yuan, W | 1 |
| Amaral, EG; Aydos, RD; Fagundes, DJ; Marks, G; Pontes, ER; Rossini, A; Takita, LC; Ynouye, CM | 1 |
| Chaabi, M; Gossé, F; Lamy, V; Lobstein, A; Raul, F; Roussi, S; Schall, N | 1 |
| Kohno, H; Miyamoto, S; Suzuki, R; Tanaka, T; Wakabayashi, K; Yasui, Y | 1 |
| Miyamoto, S; Sugie, S; Suzuki, R; Tanaka, T; Yasui, Y | 1 |
| Hirschelman, WH; Ito, A; Kinghorn, AD; Mehta, RG; Moriarty, RM; Murillo, G; Pezzuto, JM | 1 |
| Baran, AA; Bombonati, A; Hyslop, TM; Li, P; Palazzo, JP; Pitari, GM; Schulz, S; Siracusa, LD; Waldman, SA; Xu, Y | 1 |
| Becker, C; Neufert, C; Neurath, MF | 1 |
| Hirohashi, S; Honda, K; Ono, M; Satow, R; Shitashige, M; Yamada, T | 1 |
| Beppu, F; Hosokawa, M; Kohno, H; Miyamoto, S; Miyashita, K; Suzuki, R; Tanaka, T; Yasui, Y | 1 |
| Barton, JK; Besselsen, DG; Drexler, W; Gerner, EW; Hariri, LP; Hermann, B; Ignatenko, NA; McNally, J; Povazay, B; Qiu, Z; Sattmann, H; Tumlinson, AR; Unterhuber, A | 1 |
| Bissahoyo, AC; Hanlon, K; Herfarth, HH; Rubinas, TC; Threadgill, DW; Uronis, JM | 1 |
| Fujii, C; Kagaya, T; Kaneko, S; Kitamura, K; Kondo, T; Mukaida, N; Oshima, M; Popivanova, BK; Wu, Y | 1 |
| Brooke, DA; Coletta, PL; Cuthbert, RJ; Hull, MA; Ko, CW; Markham, AF; Orsi, NM; Perry, SL | 1 |
| Indranie, C; Jagan, P; Janakiram, NB; Malisetty, SV; Rao, CV; Steele, VE | 1 |
| Chang, WC; Clapper, ML; Cooper, HS; Coudry, RA; Devarajan, K; Gary, MA; Litwin, S; Lubet, RA | 1 |
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| Bird, RP; Brière, KM; Kuesel, AC; Smith, IC | 1 |
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| Chapkin, RS; Lupton, JR; Taddeo, SS; Turner, ND; Zoran, DL | 1 |
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| Benya, RV; Carroll, RE; Danilkovich, AV; Green, RM; Marrero, JA; Matkowskyj, KA | 1 |
| Aadland, E; Fagerhol, MK; Kristinsson, J; Løberg, EM; Nygaard, K; Paulsen, JE; Røseth, AG; Sundset, A | 1 |
| Le Leu, RK; McIntosh, GH; Young, GP | 1 |
| Corpet, DE; Parnaud, G; Peiffer, G; Pignatelli, B; Taché, S | 1 |
| Badger, TM; Hakkak, R; Johnston, JM; Korourian, S; Ronis, MJ | 1 |
| Boggio, M; Borrelli, F; Capasso, F; Izzo, AA; Mascolo, N; Massa, B; Mereto, E; Orsi, P; Sini, D | 1 |
| Bailey, G; Casto, B; Pereira, C; Ralston, S; Roebuck, B; Stoner, G | 1 |
| den, BM; Diederichsen, A; Fenger, C; Hansen, K; Kobaek-Larsen, M; Nissen, I; Ritskes-Hoitinga, M; Thorup, I; Vach, W | 1 |
| Houchi, H; Momen, MA; Monden, Y; Umemoto, A | 1 |
| Coghlan, L; Price, RE; Satterfield, W; Stephens, LC; Wargovich, MJ | 1 |
| Ballet, F; Delelo, R; Herve, JP; Nordlinger, B; Panis, Y; Puts, JP | 1 |
| Nordlinger, B; Panis, Y | 1 |
| Allnutt, D; Anaya, P; Palmer, C; Stephens, LC; Wargovich, MJ | 1 |
| Boyle, P; Galloway, DJ; George, WD; Hill, MJ; Jarrett, F; Owen, RW | 1 |
| Broitman, SA | 1 |
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9 review(s) available for azoxymethane and Disease Models, Animal
| Article | Year |
|---|---|
Murine models of colorectal cancer: the azoxymethane (AOM)/dextran sulfate sodium (DSS) model of colitis-associated cancer.
Topics: Animals; Azoxymethane; Colitis; Colitis-Associated Neoplasms; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Humans; Mice | 2023 |
Murine Model for Colitis-Associated Cancer of the Colon.
Topics: Animals; Azoxymethane; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Female; Humans; Male; Mice | 2016 |
Azoxymethane-induced rat aberrant crypt foci: relevance in studying chemoprevention of colon cancer.
Topics: Animals; Azoxymethane; Biomarkers, Tumor; Carcinogens; Chemoprevention; Colon; Colonic Neoplasms; Disease Models, Animal; Humans; Precancerous Conditions; Rats | 2008 |
Counterpoint: From animal models to prevention of colon cancer. Criteria for proceeding from preclinical studies and choice of models for prevention studies.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Chemoprevention; Colonic Neoplasms; Diet; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Mice; Mice, Mutant Strains; Precancerous Conditions; Randomized Controlled Trials as Topic; Rats | 2003 |
Point: From animal models to prevention of colon cancer. Systematic review of chemoprevention in min mice and choice of the model system.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Chemoprevention; Colonic Neoplasms; Diet; Disease Models, Animal; Humans; Mice; Mice, Mutant Strains; Precancerous Conditions; Randomized Controlled Trials as Topic; Rats | 2003 |
Studies with the azoxymethane-rat preclinical model for assessing colon tumor development and chemoprevention.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoxymethane; Chemoprevention; Colonic Neoplasms; Cyclooxygenase 2; Disease Models, Animal; Dose-Response Relationship, Drug; Eflornithine; Fatty Acids, Omega-3; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isoenzymes; Membrane Proteins; Models, Biological; Piroxicam; Prostaglandin-Endoperoxide Synthases; Rats; Risk Assessment | 2004 |
[Experimental models for hepatic metastases from colorectal tumors].
Topics: Animals; Azoxymethane; Colectomy; Colorectal Neoplasms; Cyclosporins; Disease Models, Animal; Fluorouracil; Liver Neoplasms; Rats; Tumor Cells, Cultured | 1991 |
Cholesterol conundrums: the relationship between dietary and serum cholesterol in colon cancer.
Topics: 1,2-Dimethylhydrazine; Adult; Animals; Azoxymethane; Cholesterol; Cholesterol, Dietary; Cholestyramine Resin; Cocarcinogenesis; Colonic Neoplasms; Diagnosis-Related Groups; Dietary Fats; Dimethylhydrazines; Disease Models, Animal; Epidemiologic Methods; Humans; Methylnitronitrosoguanidine; Methylnitrosourea | 1986 |
Dietary fat and colon cancer: variable results in animal models.
Topics: 1,2-Dimethylhydrazine; Animals; Azoxymethane; Body Weight; Cocarcinogenesis; Colonic Neoplasms; Dietary Fats; Dimethylhydrazines; Disease Models, Animal; Energy Intake; Gastrointestinal Neoplasms; Meat | 1986 |
392 other study(ies) available for azoxymethane and Disease Models, Animal
| Article | Year |
|---|---|
High-Fat Diet Promotes Colorectal Tumorigenesis Through Modulating Gut Microbiota and Metabolites.
Topics: Animals; Anti-Bacterial Agents; Azoxymethane; Bacteria; Bacterial Translocation; Cell Proliferation; Cell Transformation, Neoplastic; Colon; Colorectal Neoplasms; Diet, High-Fat; Disease Models, Animal; Dysbiosis; Fecal Microbiota Transplantation; Feces; Gastrointestinal Microbiome; Genes, APC; Germ-Free Life; Humans; Lysophospholipids; Male; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Permeability; Tumor Cells, Cultured | 2022 |
STING-mediated Syk Signaling Attenuates Tumorigenesis of Colitis‑associated Colorectal Cancer Through Enhancing Intestinal Epithelium Pyroptosis.
Topics: Animals; Azoxymethane; Carcinogenesis; Colitis; Colitis-Associated Neoplasms; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Humans; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Pyroptosis; Syk Kinase | 2022 |
Suppression of C-C chemokine receptor 1 is a key regulation for colon cancer chemoprevention in AOM/DSS mice by fucoxanthin.
Topics: Animals; Azoxymethane; Chemokines, CC; Colonic Neoplasms; Cyclin D1; Dextran Sulfate; Disease Models, Animal; Humans; Male; Mice; Mice, Inbred ICR; Proto-Oncogene Proteins c-akt; Receptors, CCR1; Smad2 Protein; Xanthophylls | 2022 |
GPR65 (TDAG8) inhibits intestinal inflammation and colitis-associated colorectal cancer development in experimental mouse models.
Topics: Animals; Azoxymethane; Colitis; Colitis-Associated Neoplasms; Colon; Dextran Sulfate; Disease Models, Animal; Fibrosis; Gene Expression Regulation; Humans; Inflammation; Inflammatory Bowel Diseases; Leukocytes; Mice; Mice, Knockout; Receptors, G-Protein-Coupled; Severity of Illness Index | 2022 |
Selenium and the 15kDa Selenoprotein Impact Colorectal Tumorigenesis by Modulating Intestinal Barrier Integrity.
Topics: Aberrant Crypt Foci; Animals; Azoxymethane; Carcinogenesis; Colonic Neoplasms; Cytokines; Dextran Sulfate; Diet; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Intestinal Mucosa; Male; Mice; Mice, Knockout; Selenoproteins; Signal Transduction; Sodium Selenite; Trace Elements | 2021 |
High-fat diet aggravates colitis-associated carcinogenesis by evading ferroptosis in the ER stress-mediated pathway.
Topics: Animals; Azoxymethane; Carcinogenesis; Colitis; Dextran Sulfate; Diet, High-Fat; Disease Models, Animal; Ferroptosis; Mice; Mice, Inbred C57BL | 2021 |
Applications and Mechanism of 3-Hydroxybutyrate (3HB) for Prevention of Colonic Inflammation and Carcinogenesis as a Food Supplement.
Topics: 3-Hydroxybutyric Acid; Animals; Azoxymethane; Carcinogenesis; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Dietary Supplements; Disease Models, Animal; Inflammation; Mice; Mice, Inbred C57BL | 2021 |
TIPE2 Promotes Tumor Initiation But Inhibits Tumor Progression in Murine Colitis-Associated Colon Cancer.
Topics: Animals; Azoxymethane; Cell Transformation, Neoplastic; Colitis; Colitis-Associated Neoplasms; Colon; Dextran Sulfate; Disease Models, Animal; Inflammation; Inflammatory Bowel Diseases; Intracellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL | 2022 |
Protective effect of Pai-Nong-San against AOM/DSS-induced CAC in mice through inhibiting the Wnt signaling pathway.
Topics: Animals; Azoxymethane; CD8-Positive T-Lymphocytes; Colitis; Dextran Sulfate; Disease Models, Animal; Drugs, Chinese Herbal; Glycogen Synthase Kinase 3 beta; Mice; Mice, Inbred C57BL; RNA, Ribosomal, 16S; Wnt Signaling Pathway | 2021 |
The Effect of TGF-β1 Reduced Functionality on the Expression of Selected Synaptic Proteins and Electrophysiological Parameters: Implications of Changes Observed in Acute Hepatic Encephalopathy.
Topics: Animals; Antibodies; Azoxymethane; Blood-Brain Barrier; Brain; Cell Line; Disease Models, Animal; Down-Regulation; Electrophysiological Phenomena; Hepatic Encephalopathy; Injections, Intraperitoneal; Liver Failure, Acute; Male; Mice; Rats; Synaptophysin; Synaptotagmins; Transforming Growth Factor beta1 | 2022 |
T-Cell-Specific CerS4 Depletion Prolonged Inflammation and Enhanced Tumor Burden in the AOM/DSS-Induced CAC Model.
Topics: Animals; Azoxymethane; Colitis-Associated Neoplasms; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Humans; Jurkat Cells; Mice; Mice, Knockout; NF-kappa B; Organ Specificity; Receptors, Antigen, T-Cell; Signal Transduction; Sphingosine N-Acyltransferase; T-Lymphocytes; Tumor Burden | 2022 |
Pre-Administration of Berberine Exerts Chemopreventive Effects in AOM/DSS-Induced Colitis-Associated Carcinogenesis Mice via Modulating Inflammation and Intestinal Microbiota.
Topics: Animals; Azoxymethane; Berberine; Carcinogenesis; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Microbiome; Inflammation; Mice; Mice, Inbred C57BL; RNA, Ribosomal, 16S | 2022 |
Phycocyanin Ameliorates Colitis-Associated Colorectal Cancer by Regulating the Gut Microbiota and the IL-17 Signaling Pathway.
Topics: Animals; Azoxymethane; Colitis; Colitis-Associated Neoplasms; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Microbiome; Interleukin-17; Mice; Mice, Inbred C57BL; Phycocyanin; Signal Transduction | 2022 |
AOM/DSS Induced Colitis-Associated Colorectal Cancer in 14-Month-Old Female Balb/C and C57/Bl6 Mice-A Pilot Study.
Topics: Animals; Azoxymethane; Carcinogenesis; Carcinoma; Colitis; Colitis-Associated Neoplasms; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Female; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Pilot Projects | 2022 |
Topics: Animals; Azoxymethane; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Dysbiosis; Gastrointestinal Microbiome; Inflammation; Lactobacillaceae; Metabolome; Mice; Mice, Inbred C57BL | 2022 |
Topics: Animals; Azoxymethane; Carcinogenesis; Colitis; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Inflammation; Kefir; Lactobacillus; Mice; RNA, Ribosomal, 16S; Saccharomyces cerevisiae; Tibet | 2022 |
Berberine inhibits intestinal carcinogenesis by suppressing intestinal pro-inflammatory genes and oncogenic factors through modulating gut microbiota.
Topics: Animals; Azoxymethane; Berberine; Carcinogenesis; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Microbiome; Humans; Mice; Mice, Inbred C57BL; NF-kappa B; RNA, Ribosomal, 16S | 2022 |
Supplementation with High or Low Iron Reduces Colitis Severity in an AOM/DSS Mouse Model.
Topics: Animals; Azoxymethane; Colitis; Dextran Sulfate; Dietary Supplements; Disease Models, Animal; Iron Overload; Iron, Dietary; Mice; Phosphatidylinositol 3-Kinases | 2022 |
Berberine regulates short-chain fatty acid metabolism and alleviates the colitis-associated colorectal tumorigenesis through remodeling intestinal flora.
Topics: Animals; Azoxymethane; Berberine; Carcinogenesis; Cell Transformation, Neoplastic; Colitis; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Fatty Acids, Volatile; Gastrointestinal Microbiome; Interleukin-6; Lipopolysaccharides; Mice; Mice, Inbred C57BL; NF-kappa B; Occludin; Tandem Mass Spectrometry; Toll-Like Receptor 4 | 2022 |
A Biscuit Containing Fucoxanthin Prevents Colorectal Carcinogenesis in Mice.
Topics: Animals; Azoxymethane; Carcinogenesis; Colitis; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Humans; Mice; Xanthophylls | 2022 |
Madecassic acid alleviates colitis-associated colorectal cancer by blocking the recruitment of myeloid-derived suppressor cells via the inhibition of IL-17 expression in γδT17 cells.
Topics: Animals; Azoxymethane; Colitis; Colitis-Associated Neoplasms; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Interleukin-17; Mice; Mice, Inbred C57BL; Myeloid-Derived Suppressor Cells; Receptors, Antigen, T-Cell, gamma-delta; Signal Transduction; Th17 Cells; Triterpenes; Tumor Microenvironment | 2022 |
Ojeok-san ameliorates visceral and somatic nociception in a mouse model of colitis induced colorectal cancer.
Topics: Animals; Azoxymethane; Colitis; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Female; Humans; Male; Mice; Mice, Inbred C57BL; Nociception; Plant Extracts | 2022 |
Lacticaseibacillus rhamnosus LS8 Ameliorates Azoxymethane/Dextran Sulfate Sodium-Induced Colitis-Associated Tumorigenesis in Mice via Regulating Gut Microbiota and Inhibiting Inflammation.
Topics: Animals; Azoxymethane; Carcinogenesis; Colitis; Dextran Sulfate; Disease Models, Animal; Dysbiosis; Gastrointestinal Microbiome; Inflammation; Lacticaseibacillus rhamnosus; Mice | 2022 |
Changes in Gut Microbiome upon Orchiectomy and Testosterone Administration in AOM/DSS-Induced Colon Cancer Mouse Model.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Colorectal Neoplasms; Disease Models, Animal; Female; Gastrointestinal Microbiome; Male; Mice; Orchiectomy; Phylogeny; RNA, Ribosomal, 16S; Testosterone | 2023 |
Natural shikonin and acetyl-shikonin improve intestinal microbial and protein composition to alleviate colitis-associated colorectal cancer.
Topics: Animals; Azoxymethane; Bacteroidetes; Colitis; Colitis-Associated Neoplasms; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Firmicutes; Humans; Inflammation; Mice; Mice, Inbred C57BL; Naphthoquinones; Tumor Microenvironment | 2022 |
Supplementation of polyphenol-rich grapes attenuates colitis, colitis-associated colon cancer, and disease-associated dysbiosis in mice, but fails to mitigate colitis in antibiotic-treated mice.
Topics: Animals; Anti-Bacterial Agents; Azoxymethane; Bacteria; Butyrates; Colitis; Colitis-Associated Neoplasms; Colon; Dextran Sulfate; Dietary Supplements; Disease Models, Animal; Dysbiosis; Mice; Mice, Inbred C57BL; Polyphenols; Powders; Vitis | 2022 |
Presume Why Probiotics May Not Provide Protection in Inflammatory Bowel Disease through an Azoxymethane and Dextran Sodium Sulfate Murine Model.
Topics: Animals; Azoxymethane; Colitis; Colitis-Associated Neoplasms; Dextran Sulfate; Disease Models, Animal; Dysbiosis; Inflammatory Bowel Diseases; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Probiotics; Sulfates | 2022 |
6- shogaol suppresses AOM/DSS-mediated colorectal adenoma through its antioxidant and anti-inflammatory effects in mice.
Topics: Adenoma; Animals; Anti-Inflammatory Agents; Antioxidants; Azoxymethane; Colonic Neoplasms; Colorectal Neoplasms; Disease Models, Animal; Inflammation; Male; Mice | 2022 |
Colitis Induces Sex-Specific Intestinal Transcriptomic Responses in Mice.
Topics: Animals; Azoxymethane; Colitis; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Female; Humans; Inflammation; Inflammatory Bowel Diseases; Male; Mice; Mice, Inbred C57BL; Receptors, Glucocorticoid; RNA; Transcriptome | 2022 |
Butyrate ameliorates colorectal cancer through regulating intestinal microecological disorders.
Topics: Animals; Azoxymethane; Butyrates; Colonic Neoplasms; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Mice; Mice, Inbred C57BL | 2023 |
Rapamycin Liposomes Combined with 5-Fluorouracil Inhibits Angiogenesis and Tumor Growth of APC
Topics: Animals; Azoxymethane; Colitis; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Fluorouracil; Lipopolysaccharides; Liposomes; Mice; Mice, Inbred C57BL; Sirolimus | 2022 |
Investigation of the gut microbiome, bile acid composition and host immunoinflammatory response in a model of azoxymethane-induced colon cancer at discrete timepoints.
Topics: Animals; Azoxymethane; Bile Acids and Salts; Carcinogenesis; Chromatography, Liquid; Colon; Colonic Neoplasms; Disease Models, Animal; Gastrointestinal Microbiome; Mice; RNA, Ribosomal, 16S; Tandem Mass Spectrometry | 2023 |
Establishment of a Novel Colitis-Associated Cancer Mouse Model Showing Flat Invasive Neoplasia.
Topics: Animals; Azoxymethane; Colitis; Colitis-Associated Neoplasms; Colorectal Neoplasms; Dextran Sulfate; Dextrans; Disease Models, Animal; Humans; Inflammation; Mice; Reproducibility of Results | 2023 |
Supplementation of quinoa peptides alleviates colorectal cancer and restores gut microbiota in AOM/DSS-treated mice.
Topics: Animals; Azoxymethane; Chenopodium quinoa; Colitis; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Microbiome; Mice; Mice, Inbred C57BL; Peptides; Probiotics | 2023 |
Interleukin-34 deficiency aggravates development of colitis and colitis-associated cancer in mice.
Topics: Animals; Azoxymethane; Carcinogenesis; Colitis; Colitis-Associated Neoplasms; Colitis, Ulcerative; Dextran Sulfate; Disease Models, Animal; Interleukins; Mice | 2022 |
Ginsenoside Rb1 Suppresses AOM/DSS-induced Colon Carcinogenesis.
Topics: Animals; Azoxymethane; Carcinogenesis; Colitis; Colon; Colorectal Neoplasms; Disease Models, Animal; Ginsenosides; Inflammation; Mice; Mice, Inbred C57BL; Tumor Microenvironment | 2023 |
Boris knockout eliminates AOM/DSS-induced in situ colorectal cancer by suppressing DNA damage repair and inflammation.
Topics: Animals; Azoxymethane; Colitis; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; DNA Damage; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout | 2023 |
AC1Q3QWB inhibits colorectal cancer progression by modulating the immune response and balancing the structure of the intestinal microbiota.
Topics: Animals; Azoxymethane; Colitis; Colon; Colonic Neoplasms; Colorectal Neoplasms; Dextran Sulfate; Dimethyl Sulfoxide; Disease Models, Animal; Gastrointestinal Microbiome; Immunity; Mice; Mice, Inbred C57BL; RNA, Ribosomal, 16S | 2023 |
Myeloid FTH1 Deficiency Protects Mice From Colitis and Colitis-associated Colorectal Cancer via Reducing DMT1-Imported Iron and STAT3 Activation.
Topics: Animals; Azoxymethane; Colitis; Colitis-Associated Neoplasms; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Iron; Mice; Mice, Inbred C57BL; STAT3 Transcription Factor | 2023 |
Metabolomic profiling for the preventive effects of dietary grape pomace against colorectal cancer.
Topics: Animals; Azoxymethane; Colorectal Neoplasms; Diet; Dietary Supplements; Disease Models, Animal; Metabolomics; Mice; Vitis | 2023 |
Sleep Fragmentation Accelerates Carcinogenesis in a Chemical-Induced Colon Cancer Model.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Azoxymethane; Carcinogenesis; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Mice; Mice, Inbred C57BL; Reactive Oxygen Species; Sleep Deprivation | 2023 |
Role of Dietary Defatted Rice Bran in the Modulation of Gut Microbiota in AOM/DSS-Induced Colitis-Associated Colorectal Cancer Rat Model.
Topics: Animals; Azoxymethane; Bacteria; Bacteroidetes; Colitis; Colitis-Associated Neoplasms; Colon; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Microbiome; Mice; Mice, Inbred C57BL; Oryza; Rats | 2023 |
Zearalenone attenuates colitis associated colorectal tumorigenesis through Ras/Raf/ERK pathway suppression and SCFA-producing bacteria promotion.
Topics: Animals; Azoxymethane; Bacteria; Carcinogenesis; Cell Transformation, Neoplastic; Colitis; Colorectal Neoplasms; Cyclin D1; Dextran Sulfate; Disease Models, Animal; Humans; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Zearalenone | 2023 |
[Anemoside B4 regulates fatty acid metabolism reprogramming in mice with colitis-associated cancer].
Topics: Animals; Azoxymethane; Colitis; Colitis-Associated Neoplasms; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Mice; Mice, Inbred C57BL; PPAR alpha; RNA, Messenger; Sterol Regulatory Element Binding Protein 1 | 2023 |
Altered gut microbiota of obesity subjects promotes colorectal carcinogenesis in mice.
Topics: Animals; Azoxymethane; Carcinogenesis; Colonic Neoplasms; Colorectal Neoplasms; Disease Models, Animal; Gastrointestinal Microbiome; Humans; Mice; Mice, Inbred C57BL; Obesity | 2023 |
Panaxynol alleviates colorectal cancer in a murine model via suppressing macrophages and inflammation.
Topics: Animals; Azoxymethane; Carcinogenesis; Cell Transformation, Neoplastic; Colitis; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Inflammation; Macrophages; Mice; Mice, Inbred C57BL; Mucins | 2023 |
A Short-Term Model of Colitis-Associated Colorectal Cancer That Suggests Initial Tumor Development and the Characteristics of Cancer Stem Cells.
Topics: Animals; Azoxymethane; beta Catenin; Colitis; Colitis-Associated Neoplasms; Colorectal Neoplasms; Cyclin D1; Dextran Sulfate; Disease Models, Animal; Humans; Ki-67 Antigen; Mice; Mice, Inbred C57BL; Neoplastic Stem Cells | 2023 |
ENPP2 inhibitor improves proliferation in AOM/DSS-induced colorectal cancer mice via remodeling the gut barrier function and gut microbiota composition.
Topics: Animals; Azoxymethane; Cell Proliferation; Colitis; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Microbiome; Mice; Mice, Inbred C57BL; Phosphoric Diester Hydrolases | 2023 |
Beneficial effects of alpha-1 antitrypsin therapy in a mouse model of colitis-associated colon cancer.
Topics: Animals; Azoxymethane; Colitis; Colitis-Associated Neoplasms; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Humans; Inflammatory Bowel Diseases; Mice; Mice, Inbred C57BL | 2023 |
Astragaloside IV inhibits AOM/DSS-induced colitis-associated tumorigenesis via activation of PPARγ signaling in mice.
Topics: Animals; Azoxymethane; Carcinogenesis; Cell Transformation, Neoplastic; Colitis; Dextran Sulfate; Disease Models, Animal; Inflammation; Mice; Mice, Inbred C57BL; PPAR gamma; Reactive Oxygen Species | 2023 |
The effect of aerobic and resistance exercise on the progression of colorectal cancer in an animal model.
Topics: Animals; Azoxymethane; Colitis; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Resistance Training | 2023 |
Chemopreventive Effects of Polysaccharides and Flavonoids from Okra Flowers in Azomethane/Dextran Sulfate Sodium-Induced Murine Colitis-Associated Cancer.
Topics: Abelmoschus; Animals; Anticarcinogenic Agents; Azoxymethane; beta Catenin; Carcinogenesis; Cell Transformation, Neoplastic; Colitis; Colitis-Associated Neoplasms; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Flavonoids; Hominidae; Humans; Interleukin-6; Mice; Mice, Inbred C57BL; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt | 2023 |
Helminth-derived molecules inhibit colitis-associated colon cancer development through NF-κB and STAT3 regulation.
Topics: Animals; Anti-Inflammatory Agents; Azoxymethane; Cell Proliferation; Cell Survival; Colitis; Colonic Neoplasms; Disease Models, Animal; Female; Helminth Proteins; Humans; Interleukin-1beta; Interleukin-33; Mice; NF-kappa B; Phosphorylation; Proto-Oncogene Mas; STAT3 Transcription Factor; Taenia; Tumor Necrosis Factor-alpha | 2019 |
Upregulation of PD-1 follows tumour development in the AOM/DSS model of inflammation-induced colorectal cancer in mice.
Topics: Animals; Azoxymethane; B7-H1 Antigen; Cell Transformation, Neoplastic; Colitis; Colon; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Intestinal Mucosa; Lymphocyte Activation; Mice, Inbred C57BL; Phenotype; Programmed Cell Death 1 Ligand 2 Protein; Programmed Cell Death 1 Receptor; Signal Transduction; T-Lymphocytes; Up-Regulation | 2019 |
Thermally Processed Oil Exaggerates Colonic Inflammation and Colitis-Associated Colon Tumorigenesis in Mice.
Topics: Animals; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Hot Temperature; Humans; Inflammation; Male; Mice; Mice, Inbred C57BL; Oils | 2019 |
Differential expression of miRNAs regulating NF-κB and STAT3 crosstalk during colitis-associated tumorigenesis.
Topics: Animals; Azoxymethane; Colitis; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; MicroRNAs; NF-kappa B; Signal Transduction; STAT3 Transcription Factor | 2019 |
Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch.
Topics: Adenocarcinoma; Animals; Appendectomy; Azoxymethane; Carcinogens; Cecum; Chronic Disease; Colitis; Colon; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Male; Mice, Inbred C57BL | 2019 |
Effect on nutritional markers of a model of aberrant crypt foci induced by azoxymethane and sodium dextran sulfate in Sprague Dawley rats.
Topics: Aberrant Crypt Foci; Animals; Azoxymethane; Carcinogens; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Male; Nutritional Physiological Phenomena; Rats; Rats, Sprague-Dawley | 2019 |
Identification of novel Nrf2 target genes as prognostic biomarkers in colitis-associated colorectal cancer in Nrf2-deficient mice.
Topics: Animals; Azoxymethane; Biomarkers; Carcinogenesis; Carcinogens; Colitis; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; NF-E2-Related Factor 2; Signal Transduction | 2019 |
Saccharomyces boulardii alleviates ulcerative colitis carcinogenesis in mice by reducing TNF-α and IL-6 levels and functions and by rebalancing intestinal microbiota.
Topics: Animals; Azoxymethane; Bacteria; Caco-2 Cells; Cell Line, Tumor; Colitis, Ulcerative; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Down-Regulation; Feces; Gastrointestinal Microbiome; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Interleukin-6; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Saccharomyces boulardii; Tumor Necrosis Factor-alpha | 2019 |
Orally Deliverable Nanotherapeutics for the Synergistic Treatment of Colitis-Associated Colorectal Cancer.
Topics: Administration, Oral; Animals; Apoptosis; Azoxymethane; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Colitis; Colorectal Neoplasms; Curcumin; Cytokines; Dextran Sulfate; Disease Models, Animal; Disease Progression; Drug Synergism; Female; Inflammation; Inflammation Mediators; Intestines; Irinotecan; Macrophages; Mice; Mice, Inbred C57BL; Nanoparticles; RAW 264.7 Cells | 2019 |
Temporal DNA methylation pattern and targeted therapy in colitis-associated cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Azoxymethane; bcl-Associated Death Protein; Carcinogenesis; Cell Line, Tumor; Colitis; Colon; Colonoscopy; Colorectal Neoplasms; Decitabine; Disease Models, Animal; Disease Progression; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Intestinal Mucosa; Male; Mice; Molecular Targeted Therapy; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; Up-Regulation | 2020 |
The impact of gut microbiota manipulation with antibiotics on colon tumorigenesis in a murine model.
Topics: Animals; Anti-Bacterial Agents; Azoxymethane; Carcinogenesis; Cell Transformation, Neoplastic; Colitis; Colorectal Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; Female; Gastrointestinal Microbiome; High-Throughput Nucleotide Sequencing; Inflammation; Mice; Mice, Inbred C57BL; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Tumor Burden | 2019 |
Identification and Characterization of Unique Neutralizing Antibodies to Mouse EGF Receptor.
Topics: Animals; Antibodies, Monoclonal, Humanized; Antibodies, Neutralizing; Azoxymethane; Carcinogens; Cells, Cultured; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; ErbB Receptors; Gastritis, Hypertrophic; Genes, Reporter; Hepatocytes; Humans; Mice; Mice, Transgenic; Primary Cell Culture | 2020 |
Switching to a Healthy Diet Prevents the Detrimental Effects of Western Diet in a Colitis-Associated Colorectal Cancer Model.
Topics: Aberrant Crypt Foci; Animals; Azoxymethane; Colitis; Colon; Colorectal Neoplasms; Dextran Sulfate; Diet, Healthy; Diet, Western; Disease Models, Animal; Female; Gastrointestinal Microbiome; Liver; Mice; Mice, Inbred BALB C; Vitamin D | 2019 |
A New Polygenic Model for Nonfamilial Colorectal Cancer Inheritance Based on the Genetic Architecture of the Azoxymethane-Induced Mouse Model.
Topics: Alleles; Animals; Azoxymethane; Colorectal Neoplasms; Disease Models, Animal; Drug Resistance, Neoplasm; Genetic Heterogeneity; Genetic Predisposition to Disease; Genome-Wide Association Study; Heredity; Humans; Mice; Mice, Inbred Strains; Models, Genetic; Multifactorial Inheritance | 2020 |
Effects of high-fat diet and intestinal aryl hydrocarbon receptor deletion on colon carcinogenesis.
Topics: Animals; Azoxymethane; Basic Helix-Loop-Helix Transcription Factors; beta Catenin; Cell Proliferation; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Diet, High-Fat; Disease Models, Animal; DNA Damage; Epithelial Cells; Gene Deletion; Gene Expression Regulation, Neoplastic; Intestinal Mucosa; Mice, Inbred C57BL; Mice, Knockout; Precancerous Conditions; Receptors, Aryl Hydrocarbon; Signal Transduction | 2020 |
Affective state determination in a mouse model of colitis-associated colorectal cancer.
Topics: Animals; Azoxymethane; Behavior; Buprenorphine; Colitis; Colonoscopy; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Mice; Mice, Inbred C57BL; Pain Measurement; Retrospective Studies; Risk Assessment | 2020 |
Consumption of the Total Western Diet Promotes Colitis and Inflammation-Associated Colorectal Cancer in Mice.
Topics: Adaptive Immunity; Animals; Azoxymethane; Carcinogenesis; Cell Transformation, Neoplastic; Colitis; Colon; Colorectal Neoplasms; Dextran Sulfate; Diet, Western; Disease Models, Animal; Immunity, Innate; Inflammation; Intestinal Mucosa; Mice; Mice, Inbred C57BL; RNA, Messenger | 2020 |
Dietary Mixed Cereal Grains Ameliorate the Azoxymethane and Dextran Sodium Sulfate-Induced Colonic Carcinogenesis in C57BL/6J Mice.
Topics: Animals; Azoxymethane; Carcinogenesis; Caspase 3; Colon; Colonic Neoplasms; Colorectal Neoplasms; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Cyclooxygenase 2; Cytokines; Dextran Sulfate; Dietary Carbohydrates; Disease Models, Animal; Edible Grain; Interleukin-1beta; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; RNA, Messenger; Tumor Necrosis Factors; Tumor Suppressor Protein p53 | 2020 |
Alpha-Glucosidase Inhibitor Voglibose Suppresses Azoxymethane-Induced Colonic Preneoplastic Lesions in Diabetic and Obese Mice.
Topics: Animals; Antioxidants; Azoxymethane; Biomarkers; Biopsy; Cell Proliferation; Colonic Neoplasms; Cytokines; Diabetes Mellitus, Type 2; Disease Models, Animal; Glycoside Hydrolase Inhibitors; Humans; Inflammation Mediators; Inositol; Intestinal Mucosa; Mice; NF-kappa B; Obesity; Oxidative Stress; Precancerous Conditions | 2020 |
miR-370-3p Alleviates Ulcerative Colitis-Related Colorectal Cancer in Mice Through Inhibiting the Inflammatory Response and Epithelial-Mesenchymal Transition.
Topics: Animals; Azoxymethane; Cell Proliferation; Cells, Cultured; Colitis, Ulcerative; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Epithelial-Mesenchymal Transition; Humans; Inflammation; Male; Mice; Mice, Inbred C57BL; MicroRNAs | 2020 |
Catalpol‑mediated microRNA‑34a suppresses autophagy and malignancy by regulating SIRT1 in colorectal cancer.
Topics: Aged; Animals; Apoptosis; Autophagy; Azoxymethane; Carcinogens; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colonic Neoplasms; Colorectal Neoplasms; Disease Models, Animal; Drugs, Chinese Herbal; Female; Gene Expression Regulation, Neoplastic; Humans; Iridoid Glucosides; Male; MicroRNAs; Middle Aged; Rats; Rats, Wistar; Rehmannia; Sirtuin 1; Up-Regulation | 2020 |
Administration of Bifidobacterium bifidum CGMCC 15068 modulates gut microbiota and metabolome in azoxymethane (AOM)/dextran sulphate sodium (DSS)-induced colitis-associated colon cancer (CAC) in mice.
Topics: Animals; Azoxymethane; Bifidobacterium bifidum; Carcinogenesis; Colitis-Associated Neoplasms; Dextran Sulfate; Disease Models, Animal; Feces; Gastrointestinal Microbiome; Male; Metabolome; Mice; Mice, Inbred C57BL; Probiotics | 2020 |
Aspirin Reduces Colorectal Tumor Development in Mice and Gut Microbes Reduce its Bioavailability and Chemopreventive Effects.
Topics: Adenomatous Polyposis Coli Protein; Animals; Anti-Bacterial Agents; Anticarcinogenic Agents; Aspirin; Azoxymethane; Bacillaceae; Bacteroides fragilis; Bacteroidetes; Biological Availability; Carcinogenesis; Colitis; Colon; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; DNA, Bacterial; Dose-Response Relationship, Drug; Feces; Gastrointestinal Microbiome; Germ-Free Life; Humans; Intestinal Mucosa; Male; Mice; Mice, Transgenic; RNA, Ribosomal, 16S | 2020 |
Quercetin Suppresses AOM/DSS-Induced Colon Carcinogenesis through Its Anti-Inflammation Effects in Mice.
Topics: Animals; Antineoplastic Agents; Azoxymethane; Biomarkers, Tumor; Carcinogenesis; Colon; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Gentian Violet; Humans; Hydroxybutyrates; Mice; Mice, Inbred C57BL; Oxidative Stress; Quercetin; Tumor Burden | 2020 |
Effect of PIERCE1 on colorectal cancer.
Topics: Animals; Azoxymethane; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Female; Gene Expression; Humans; Male; Mice, Transgenic; Tumor Suppressor Protein p53 | 2020 |
Clostridium butyricum modulates gut microbiota and reduces colitis associated colon cancer in mice.
Topics: Animals; Apoptosis; Azoxymethane; Bacteroidetes; Body Weight; Cell Proliferation; Clostridium butyricum; Colitis; Colitis-Associated Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; Feces; Firmicutes; Gastrointestinal Microbiome; Inflammation; Male; Mice, Inbred C57BL; NF-kappa B p50 Subunit; RNA, Ribosomal, 16S | 2020 |
Dietary Supplementation of Foxtail Millet Ameliorates Colitis-Associated Colorectal Cancer in Mice via Activation of Gut Receptors and Suppression of the STAT3 Pathway.
Topics: Animals; Azoxymethane; Basic Helix-Loop-Helix Transcription Factors; Colitis-Associated Neoplasms; Colorectal Neoplasms; Dextran Sulfate; Diet; Dietary Supplements; Disease Models, Animal; Disease Progression; Gastrointestinal Microbiome; Interleukin-17; Interleukin-6; Mice; Mice, Inbred BALB C; Oryza; Phosphorylation; Receptors, Aryl Hydrocarbon; Receptors, G-Protein-Coupled; Setaria Plant; Signal Transduction; STAT3 Transcription Factor | 2020 |
Effects of triptolide on the sphingosine kinase - Sphingosine-1-phosphate signaling pathway in colitis-associated colon cancer.
Topics: Animals; Azoxymethane; Colitis; Colitis-Associated Neoplasms; Colon; Dextran Sulfate; Disease Models, Animal; Diterpenes; Epoxy Compounds; Female; Humans; Lysophospholipids; Male; Mice, Inbred BALB C; Mice, Inbred ICR; Mice, Nude; Phenanthrenes; Phosphotransferases (Alcohol Group Acceptor); Signal Transduction; Sphingosine; THP-1 Cells; Tumor-Associated Macrophages | 2020 |
ARC Is a Critical Protector against Inflammatory Bowel Disease (IBD) and IBD-Associated Colorectal Tumorigenesis.
Topics: Animals; Apoptosis Regulatory Proteins; Azoxymethane; Bone Marrow Transplantation; CD4-Positive T-Lymphocytes; Chemokine CCL5; Chemokine CXCL5; Colitis; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Female; Humans; Inflammatory Bowel Diseases; Intracellular Signaling Peptides and Proteins; Jurkat Cells; Male; Mice, Inbred C57BL; Mice, Knockout; Muscle Proteins; Ubiquitination | 2020 |
Targeted Delivery of CXCL9 and OX40L by Mesenchymal Stem Cells Elicits Potent Antitumor Immunity.
Topics: Animals; Azoxymethane; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Chemokine CXCL9; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Immunotherapy, Adoptive; Killer Cells, Natural; Lymphocytes, Tumor-Infiltrating; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; OX40 Ligand; Transduction, Genetic; Transplantation, Isogeneic; Treatment Outcome; Tumor Microenvironment | 2020 |
Thrombocytosis and Effects of IL-6 Knock-Out in a Colitis-Associated Cancer Model.
Topics: Animals; Azoxymethane; Colitis-Associated Neoplasms; Dextran Sulfate; Disease Models, Animal; Gene Knockout Techniques; Interleukin-6; Magnetic Resonance Imaging; Male; Mice; Platelet Count; Positron-Emission Tomography; Thrombocytosis; Thrombopoietin | 2020 |
Toll-like receptor 4 prevents AOM/DSS-induced colitis-associated colorectal cancer in Bacteroides fragilis gnotobiotic mice.
Topics: Animals; Azoxymethane; Bacteroides fragilis; beta Catenin; Colitis; Colitis-Associated Neoplasms; Colon; Colorectal Neoplasms; Cyclooxygenase 2; Dextran Sulfate; Disease Models, Animal; Germ-Free Life; Male; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase Type II; Proliferating Cell Nuclear Antigen; Toll-Like Receptor 4 | 2021 |
Alteration of fecal microbiota by fucoxanthin results in prevention of colorectal cancer in AOM/DSS mice.
Topics: Adenocarcinoma; Animals; Azoxymethane; Colitis-Associated Neoplasms; Colitis, Ulcerative; Dextran Sulfate; Disease Models, Animal; Drug Screening Assays, Antitumor; Feces; Gastrointestinal Microbiome; Humans; Intestinal Mucosa; Male; Mice; Xanthophylls | 2021 |
Emu oil and grape seed extract reduce tumour burden and disease parameters in murine colitis-associated colorectal cancer.
Topics: Animals; Azoxymethane; Colitis-Associated Neoplasms; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Drug Screening Assays, Antitumor; Female; Grape Seed Extract; Humans; Intestinal Mucosa; Male; Mice; Oils; Severity of Illness Index; Tumor Burden | 2021 |
The Interplay Between Innate Immunity (TLR-4) and sCD40L in the Context of an Animal Model of Colitis-associated Cancer.
Topics: Animals; Azoxymethane; CD40 Ligand; Colitis; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Humans; Immunity, Innate; Mice; Mice, Knockout; Toll-Like Receptor 4 | 2020 |
The chemopreventive effects of Huangqin-tea against AOM-induced preneoplastic colonic aberrant crypt foci in rats and omics analysis.
Topics: Aberrant Crypt Foci; Animals; Anticarcinogenic Agents; Azoxymethane; Colonic Neoplasms; Disease Models, Animal; Functional Food; Male; Rats; Rats, Wistar; Scutellaria baicalensis; Tea | 2020 |
Stroma-derived ANGPTL2 establishes an anti-tumor microenvironment during intestinal tumorigenesis.
Topics: Angiopoietin-Like Protein 2; Angiopoietin-like Proteins; Animals; Azoxymethane; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Colitis; Dextran Sulfate; Disease Models, Animal; Gene Knockout Techniques; Intestinal Neoplasms; Macrophages; Mice; NF-kappa B; Signal Transduction; Tumor Microenvironment | 2021 |
Inhibitory Effects of Apigenin on Tumor Carcinogenesis by Altering the Gut Microbiota.
Topics: Animals; Apigenin; Azoxymethane; Carcinogenesis; Dextran Sulfate; Disease Models, Animal; Female; Gastrointestinal Microbiome; Mice; Mice, Inbred BALB C; RNA, Ribosomal, 16S | 2020 |
Epithelial TLR4 Signaling Activates DUOX2 to Induce Microbiota-Driven Tumorigenesis.
Topics: Animals; Azoxymethane; Carcinogenesis; Colitis-Associated Neoplasms; Colitis, Ulcerative; Colon; Datasets as Topic; Dextran Sulfate; Disease Models, Animal; Dual Oxidases; Gastrointestinal Microbiome; Germ-Free Life; Humans; Hydrogen Peroxide; Intestinal Mucosa; Membrane Proteins; Mice; Mice, Knockout; NADPH Oxidase 1; Toll-Like Receptor 4 | 2021 |
Behaviour of citrus pectin and modified citrus pectin in an azoxymethane/dextran sodium sulfate (AOM/DSS)-induced rat colorectal carcinogenesis model.
Topics: Acetates; Animals; Azoxymethane; Bifidobacterium; Blood Glucose; Body Weight; Butyrates; Carcinogenesis; Chromatography, High Pressure Liquid; Citrus; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Microbiome; Hydrogen-Ion Concentration; Lactic Acid; Lactobacillaceae; Male; Metagenomics; Pectins; Phylogeny; Propionates; Proteobacteria; Rats; Rats, Inbred F344; Triglycerides | 2021 |
Inducible mouse models of colon cancer for the analysis of sporadic and inflammation-driven tumor progression and lymph node metastasis.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Disease Progression; Female; Inflammation; Lymphatic Metastasis; Male; Mice; Mice, Inbred C57BL | 2021 |
Colonic Epithelial-Derived Selenoprotein P Is the Source for Antioxidant-Mediated Protection in Colitis-Associated Cancer.
Topics: Adolescent; Animals; Azoxymethane; Case-Control Studies; Cell Transformation, Neoplastic; Child; Child, Preschool; Colitis; Colitis-Associated Neoplasms; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; DNA Damage; Female; Genomic Instability; Humans; Intestinal Mucosa; Liver; Male; Mice, Knockout; Myeloid Cells; Oxidative Stress; Selenoprotein P | 2021 |
Novel FXR agonist nelumal A suppresses colitis and inflammation-related colorectal carcinogenesis.
Topics: Acrolein; Animals; Azoxymethane; Carcinogenesis; Carcinogens; Colitis; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Inflammation; Male; Mice; Mice, Inbred A; RNA-Binding Proteins | 2021 |
Vitexin prevents colitis-associated carcinogenesis in mice through regulating macrophage polarization.
Topics: Animals; Anticarcinogenic Agents; Apigenin; Azoxymethane; Carcinogenesis; Colitis; Colorectal Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; Inflammatory Bowel Diseases; Macrophages; Male; Mice, Inbred BALB C; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III | 2021 |
Induction of colitis-associated neoplasia in mice using azoxymethane and dextran sodium sulfate.
Topics: Animals; Azoxymethane; Colitis; Colonic Neoplasms; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Mice; Mice, Inbred C57BL; Sulfates | 2021 |
Glycyrrhizin Attenuates Carcinogenesis by Inhibiting the Inflammatory Response in a Murine Model of Colorectal Cancer.
Topics: Animals; Azoxymethane; Carcinogenesis; Colon; Colorectal Neoplasms; Disease Models, Animal; Female; Glycyrrhizic Acid; HMGB1 Protein; Inflammation; Interleukin-6; Mice; Mice, Inbred ICR; NF-kappa B; Signal Transduction; Tumor Necrosis Factor-alpha | 2021 |
An Optimized Protocol of Azoxymethane-Dextran Sodium Sulfate Induced Colorectal Tumor Model in Mice.
Topics: Adenocarcinoma; Adenoma; Animals; Azoxymethane; Body Weight; Carcinogenesis; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Male; Mice, Inbred C57BL | 2019 |
Cardamonin Attenuates Experimental Colitis and Associated Colorectal Cancer.
Topics: Animals; Anti-Inflammatory Agents; Azoxymethane; Cell Proliferation; Cell Survival; Chalcones; Colitis; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Mice; MicroRNAs; Nitrous Oxide; RAW 264.7 Cells; Sequence Analysis, RNA; Signal Transduction; THP-1 Cells | 2021 |
γδ T Cells Control Gut Pathology in a Chronic Inflammatory Model of Colorectal Cancer.
Topics: Animals; Azoxymethane; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Intraepithelial Lymphocytes; Mice; Receptors, Antigen, T-Cell | 2021 |
Alisol B 23-Acetate Ameliorates Azoxymethane/Dextran Sodium Sulfate-Induced Male Murine Colitis-Associated Colorectal Cancer
Topics: Animals; Azoxymethane; China; Cholestenones; Colitis; Colitis-Associated Neoplasms; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Microbiome; Male; Mice; Mice, Inbred C57BL; Sulfates | 2021 |
Galectin-1 fosters an immunosuppressive microenvironment in colorectal cancer by reprogramming CD8
Topics: Adenocarcinoma; Animals; Atlases as Topic; Azoxymethane; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Colitis; Colorectal Neoplasms; Computational Biology; Dextran Sulfate; Disease Models, Animal; Galectin 1; Gene Expression Regulation, Neoplastic; Humans; Interleukin-2 Receptor beta Subunit; Mice; Mice, Knockout; Programmed Cell Death 1 Receptor; Signal Transduction; Survival Analysis; T-Lymphocytes, Regulatory; Tumor Burden | 2021 |
Limonin modulated immune and inflammatory responses to suppress colorectal adenocarcinoma in mice model.
Topics: Adenocarcinoma; Animals; Antioxidants; Azoxymethane; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Inflammation; Limonins; Male; Mice; Mice, Inbred BALB C; Oxidative Stress | 2021 |
Aspirin inhibits prostaglandins to prevents colon tumor formation via down-regulating Wnt production.
Topics: Animals; Aspirin; Azoxymethane; Cell Transformation, Neoplastic; Colitis; Colitis-Associated Neoplasms; Dextran Sulfate; Dinoprostone; Disease Models, Animal; Down-Regulation; Humans; Male; Mice; Nuclear Receptor Subfamily 4, Group A, Member 2; Proteomics; Proto-Oncogene Proteins; Wnt Proteins; Wnt Signaling Pathway | 2021 |
Transcriptome analysis of potential candidate genes and molecular pathways in colitis-associated colorectal cancer of Mkp-1-deficient mice.
Topics: Animals; Azoxymethane; Biomarkers, Tumor; Carcinogenesis; Colitis; Colitis-Associated Neoplasms; Computational Biology; Dextran Sulfate; Disease Models, Animal; Dual Specificity Phosphatase 1; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Mice, Knockout; Prognosis; Protein Interaction Mapping; Protein Interaction Maps; RNA-Seq; Signal Transduction | 2021 |
A synthetic probiotic engineered for colorectal cancer therapy modulates gut microbiota.
Topics: Animals; Azoxymethane; Colitis; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Microbiome; Mice; Mice, Inbred C57BL; Probiotics | 2021 |
Phaseolin, a Protein from the Seed of
Topics: Aberrant Crypt Foci; Animals; Antioxidants; Azoxymethane; Chemical and Drug Induced Liver Injury; Chemoprevention; Colitis; Colon; Disease Models, Animal; DNA Damage; Male; Mice; Oxidation-Reduction; Oxidative Stress; Phaseolus; Plant Extracts; Protective Agents; Seeds | 2021 |
Scutellarin ameliorates colitis-associated colorectal cancer by suppressing Wnt/β-catenin signaling cascade.
Topics: Animals; Apigenin; Azoxymethane; Carcinogenesis; Colitis-Associated Neoplasms; Colitis, Ulcerative; Dextran Sulfate; Disease Models, Animal; Drug Screening Assays, Antitumor; Gene Expression Regulation, Neoplastic; Glucuronates; HT29 Cells; Humans; Male; Mice; Wnt Signaling Pathway | 2021 |
Lactobacillus coryniformis MXJ32 administration ameliorates azoxymethane/dextran sulfate sodium-induced colitis-associated colorectal cancer via reshaping intestinal microenvironment and alleviating inflammatory response.
Topics: Animals; Azoxymethane; Colitis; Colitis-Associated Neoplasms; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Lactobacillus; Mice; Mice, Inbred C57BL; Probiotics; Tumor Microenvironment | 2022 |
Inhibitory Effect of Garcinol on Obesity-Exacerbated, Colitis-Mediated Colon Carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Biomarkers; Cell Proliferation; Colitis; Colonic Neoplasms; Cytokines; Dextran Sulfate; Diet, High-Fat; Disease Models, Animal; Dysbiosis; Gastrointestinal Microbiome; Gene Expression Regulation, Neoplastic; Lipids; Male; Mice, Inbred C57BL; Obesity; Organ Size; Proliferating Cell Nuclear Antigen; Terpenes | 2021 |
Mitochondrial DNA Integrity Is Maintained by APE1 in Carcinogen-Induced Colorectal Cancer.
Topics: Animals; Azoxymethane; Carcinogens; Colorectal Neoplasms; Disease Models, Animal; DNA Damage; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; DNA, Mitochondrial; Genome, Mitochondrial; Humans; Mice; Mice, Transgenic | 2017 |
Cysteinyl leukotriene receptor 1 facilitates tumorigenesis in a mouse model of colitis-associated colon cancer.
Topics: Animals; Azoxymethane; beta Catenin; Body Weight; Colitis; Colonic Neoplasms; Cyclooxygenase 2; Dextran Sulfate; Disease Models, Animal; Mice; Receptors, Leukotriene | 2017 |
Expression of A-kinase anchor protein 13 and Rho-associated coiled-coil containing protein kinase in restituted and regenerated mucosal epithelial cells following mucosal injury and colorectal cancer cells in mouse models.
Topics: A Kinase Anchor Proteins; Animals; Azoxymethane; Colitis; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Female; Guanine Nucleotide Exchange Factors; Intestinal Mucosa; Mice; Mice, Inbred BALB C; Minor Histocompatibility Antigens; Regeneration; rho-Associated Kinases; Wound Healing | 2017 |
Clostridium butyricum partially regulates the development of colitis-associated cancer through miR-200c.
Topics: Animals; Azoxymethane; Carcinogenesis; Cell Proliferation; Clostridium butyricum; Colitis; Colonic Neoplasms; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Humans; In Situ Hybridization, Fluorescence; Inflammation; Interleukin-12; Mice; MicroRNAs; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2017 |
Intermittent Dosing with Sulindac Provides Effective Colorectal Cancer Chemoprevention in the Azoxymethane-Treated Mouse Model.
Topics: Animals; Antineoplastic Agents; Azoxymethane; Carcinogens; Chemoprevention; Colorectal Neoplasms; Disease Models, Animal; Female; Mice; Sulindac | 2017 |
E-cadherin Mediates the Preventive Effect of Vitamin D3 in Colitis-associated Carcinogenesis.
Topics: Animals; Azoxymethane; beta Catenin; Cadherins; Carcinogenesis; Cell Proliferation; Cholecalciferol; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Up-Regulation; Vitamins | 2017 |
Gavage of Fecal Samples From Patients With Colorectal Cancer Promotes Intestinal Carcinogenesis in Germ-Free and Conventional Mice.
Topics: Animals; Azoxymethane; Case-Control Studies; Cell Proliferation; Cell Transformation, Neoplastic; Colon; Colonic Polyps; Colorectal Neoplasms; Disease Models, Animal; Feces; Gastrointestinal Microbiome; Gene Expression Regulation, Neoplastic; Germ-Free Life; Host-Pathogen Interactions; Humans; Inflammation Mediators; Ki-67 Antigen; Lymphocytes, Tumor-Infiltrating; Male; Mice, Inbred C57BL; Th1 Cells; Th17 Cells | 2017 |
Enhancing miR-132 expression by aryl hydrocarbon receptor attenuates tumorigenesis associated with chronic colitis.
Topics: Acetylcholinesterase; Animals; Azoxymethane; Carcinogenesis; Cell Movement; Cells, Cultured; Colitis, Ulcerative; Colon; Colonic Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; Female; Gene Expression Regulation, Neoplastic; Humans; Inflammation Mediators; Macrophages; Mice; Mice, Inbred C57BL; MicroRNAs; Polychlorinated Dibenzodioxins; Receptors, Aryl Hydrocarbon; RNA, Small Interfering | 2017 |
Macrophage depletion using clodronate liposomes decreases tumorigenesis and alters gut microbiota in the AOM/DSS mouse model of colon cancer.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Biomarkers, Tumor; Cell Transformation, Neoplastic; Clodronic Acid; Colon; Colonic Polyps; Colorectal Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Microbiome; Host-Pathogen Interactions; Inflammation Mediators; Liposomes; Macrophages; Male; Mice, Inbred C57BL; Signal Transduction; Time Factors; Tumor Burden | 2018 |
Combination Strategy of Quantitative Proteomics Uncovers the Related Proteins of Colorectal Cancer in the Interstitial Fluid of Colonic Tissue from the AOM-DSS Mouse Model.
Topics: Animals; Azoxymethane; Biomarkers, Tumor; Blood Proteins; Chromatography, Liquid; Colon; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Extracellular Fluid; Humans; Male; Mass Spectrometry; Mice; Mice, Inbred C57BL; Proteome; Proteomics; Tumor Microenvironment | 2018 |
Small molecules related to adrenomedullin reduce tumor burden in a mouse model of colitis-associated colon cancer.
Topics: Adrenomedullin; Animals; Antineoplastic Agents; Azoxymethane; Cluster Analysis; Colitis; Colon; Colonic Neoplasms; Disease Models, Animal; Disease Progression; Gastrointestinal Agents; Mice | 2017 |
Methylglyoxal displays colorectal cancer-promoting properties in the murine models of azoxymethane and CT26 isografts.
Topics: Animals; Azoxymethane; Carcinogenesis; Carcinogens; Cell Line; Cholesterol, LDL; Colorectal Neoplasms; Disease Models, Animal; Humans; Inflammation; Male; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Oxidative Stress; Precancerous Conditions; Pyruvaldehyde; Transplantation, Isogeneic | 2018 |
Pretreatment with probiotic Bifico ameliorates colitis-associated cancer in mice: Transcriptome and gut flora profiling.
Topics: Administration, Oral; Animals; Azoxymethane; Bacteria; Chemokines, CXC; Colitis; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Microbiome; Gene Expression Profiling; Humans; Male; Mice; Mice, Inbred C57BL; Probiotics; RNA, Ribosomal, 16S; Signal Transduction; Xenograft Model Antitumor Assays | 2018 |
Structural shift of gut microbiota during chemo-preventive effects of epigallocatechin gallate on colorectal carcinogenesis in mice.
Topics: Aberrant Crypt Foci; Animals; Anticarcinogenic Agents; Azoxymethane; Carcinogenesis; Carcinogens; Catechin; Colon; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Female; Gastrointestinal Microbiome; Humans; Mice; Rectum; RNA, Ribosomal, 16S | 2017 |
Physicochemical and nutraceutical properties of moringa (Moringa oleifera) leaves and their effects in an in vivo AOM/DSS-induced colorectal carcinogenesis model.
Topics: Animals; Antioxidants; Azoxymethane; beta-Glucosidase; Chemical Phenomena; Colorectal Neoplasms; Diet Therapy; Dietary Fiber; Dietary Supplements; Disease Models, Animal; Feces; Glucuronidase; Male; Mice; Moringa oleifera; Phenols; Phytochemicals; Plant Extracts; Plant Leaves; Tryptophanase; Urease | 2018 |
DNA methylome and transcriptome alterations and cancer prevention by curcumin in colitis-accelerated colon cancer in mice.
Topics: Animals; Azoxymethane; Colitis; Colon; Colonic Neoplasms; Curcumin; Dextran Sulfate; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Inflammation; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Transcriptome | 2018 |
Natural dietary compound naringin prevents azoxymethane/dextran sodium sulfate-induced chronic colorectal inflammation and carcinogenesis in mice.
Topics: Animals; Autophagy; Azoxymethane; Biomarkers; Cell Transformation, Neoplastic; Colitis; Colorectal Neoplasms; Cytokines; Dietary Supplements; Disease Models, Animal; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Flavanones; Inflammation Mediators; Intestinal Mucosa; Male; Mice; Sulfates | 2018 |
Chemopreventive Effects of Edible Canna (Canna edulis Kerr.) Against Colorectal Carcinogenesis: Effects on Expression of Adenomatous Polyposis Coli and Inducible Nitric Oxide Synthase in Rat Inflammatory Model
Topics: Adenomatous Polyposis Coli Protein; Animals; Azoxymethane; Carcinogens; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Gene Expression Regulation; Male; Nitric Oxide Synthase Type II; Plant Extracts; Rats; Rats, Wistar; Zingiberales | 2018 |
Tea Polysaccharides Inhibit Colitis-Associated Colorectal Cancer via Interleukin-6/STAT3 Pathway.
Topics: Animals; Antineoplastic Agents, Phytogenic; Azoxymethane; Camellia sinensis; Cell Line, Tumor; Colitis; Colorectal Neoplasms; Dextran Sulfate; Dietary Supplements; Disease Models, Animal; Inflammation; Interleukin-6; Macrophages; Mice; Mice, Inbred BALB C; Polysaccharides; RAW 264.7 Cells; Signal Transduction; STAT3 Transcription Factor; Tea | 2018 |
Dietary fat and fiber interact to uniquely modify global histone post-translational epigenetic programming in a rat colon cancer progression model.
Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Dietary Fats; Dietary Fiber; Disease Models, Animal; Epigenesis, Genetic; Fish Oils; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; High-Throughput Nucleotide Sequencing; Histones; Male; Rats; Rats, Sprague-Dawley | 2018 |
Microsatellite Instability in Mouse Models of Colorectal Cancer.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoxymethane; Colon; Colonic Neoplasms; Disease Models, Animal; Mice; Mice, Knockout; Microsatellite Instability; Microsatellite Repeats; MutS Homolog 2 Protein; Sulindac; Tumor Suppressor Protein p53 | 2018 |
Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice.
Topics: Animals; Azoxymethane; Bifidobacterium; Colitis; Colon; Colonic Neoplasms; Cytokines; Disease Models, Animal; Gastrointestinal Microbiome; Humans; Intestinal Mucosa; Lacticaseibacillus rhamnosus; Lactobacillus acidophilus; Male; Mice; Mice, Inbred C57BL; Probiotics; RNA, Ribosomal, 16S | 2018 |
Tumor Necrosis Factor Ligand-Related Molecule 1A Regulates the Occurrence of Colitis-Associated Colorectal Cancer.
Topics: Animals; Azoxymethane; beta Catenin; Cell Movement; Cell Proliferation; Colitis; Colorectal Neoplasms; Cyclin D1; Dextran Sulfate; Disease Models, Animal; Gene Expression Regulation, Neoplastic; HCT116 Cells; HT29 Cells; Humans; Mice, Inbred C57BL; Mice, Transgenic; Neoplasm Invasiveness; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins c-myc; Time Factors; Tumor Necrosis Factor Ligand Superfamily Member 15; Wnt Signaling Pathway | 2018 |
A Novel Modification of the AOM/DSS Model for Inducing Intestinal Adenomas in Mice.
Topics: Adenoma; Animals; Azoxymethane; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Female; Humans; Intestinal Neoplasms; Mice, Inbred C57BL | 2018 |
Direct Comparison of the Thioacetamide and Azoxymethane Models of Type A Hepatic Encephalopathy in Mice.
Topics: Animals; Azoxymethane; Biomarkers; Brain; Disease Models, Animal; Hepatic Encephalopathy; Liver; Male; Mice; Mice, Inbred C57BL; Thioacetamide | 2018 |
Over-expressed miRNA-200b ameliorates ulcerative colitis-related colorectal cancer in mice through orchestrating epithelial-mesenchymal transition and inflammatory responses by channel of AKT2.
Topics: 3' Untranslated Regions; Animals; Azoxymethane; Cells, Cultured; Colitis, Ulcerative; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Epithelial-Mesenchymal Transition; Genetic Therapy; Humans; Inflammation Mediators; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Proto-Oncogene Proteins c-akt; Signal Transduction; Transgenes; Tumor Necrosis Factor-alpha | 2018 |
Geminin ablation in vivo enhances tumorigenesis through increased genomic instability.
Topics: Adenoma; Animals; Ataxia Telangiectasia Mutated Proteins; Azoxymethane; Carcinoma; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Geminin; Genes, Tumor Suppressor; Genetic Predisposition to Disease; Genomic Instability; Histones; Lung Neoplasms; Mice, Inbred C57BL; Mice, Knockout; Phenotype; Phosphorylation; Urethane | 2018 |
The Rac1 splice form Rac1b favors mouse colonic mucosa regeneration and contributes to intestinal cancer progression.
Topics: Animals; Azoxymethane; Carcinogenesis; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Disease Progression; Epithelial Cells; Inflammation; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Neuropeptides; rac1 GTP-Binding Protein; Signal Transduction | 2018 |
Deletion of cadherin-17 enhances intestinal permeability and susceptibility to intestinal tumour formation.
Topics: Active Transport, Cell Nucleus; Adaptor Proteins, Signal Transducing; Adenoma; Animals; Azoxymethane; Cadherins; Carcinoma; Cell Cycle Proteins; Colitis; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Gene Deletion; Genetic Predisposition to Disease; Intestinal Absorption; Intestinal Mucosa; Mice, Inbred C57BL; Mice, Knockout; Permeability; Phenotype; Phosphoproteins; Signal Transduction; Tumor Suppressor Proteins; YAP-Signaling Proteins | 2018 |
Effect of Estradiol in an Azoxymethane/Dextran Sulfate Sodium-Treated Mouse Model of Colorectal Cancer: Implication for Sex Difference in Colorectal Cancer Development.
Topics: Animals; Azoxymethane; Biomarkers; Biopsy; Carcinogens; Cell Transformation, Neoplastic; Colorectal Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; Disease Progression; Disease Susceptibility; Estradiol; Female; Humans; Immunohistochemistry; Inflammation Mediators; Male; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Sex Factors | 2019 |
Chemoprevention of inflammation-related colorectal cancer by silymarin-, acetyl-11-keto-beta-boswellic acid-, curcumin- and maltodextrin-enriched dietetic formulation in animal model.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Azoxymethane; Chemoprevention; Colitis; Colon; Colonoscopy; Colorectal Neoplasms; Curcumin; Cytokines; Dextran Sulfate; Disease Models, Animal; Food, Fortified; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Polysaccharides; Real-Time Polymerase Chain Reaction; Receptors, Estrogen; Silymarin; Triterpenes | 2018 |
Early increase in blood supply (EIBS) is associated with tumor risk in the Azoxymethane model of colon cancer.
Topics: Animals; Azoxymethane; Blood Vessels; Carcinogenesis; Colon; Colonic Neoplasms; Dextrans; Disease Models, Animal; Fluorescein-5-isothiocyanate; Hemoglobins; Humans; Mice; Microscopy, Confocal; Renin-Angiotensin System | 2018 |
DNA damage response genes mark the early transition from colitis to neoplasia in colitis-associated colon cancer.
Topics: Animals; Azoxymethane; Carcinogenesis; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Disease Progression; DNA Damage; Gene Expression Regulation; Inflammation; Inflammatory Bowel Diseases; Intestines; Male; Mice; Mice, Inbred C57BL; Microsatellite Instability; Signal Transduction | 2018 |
Deceleration of glycometabolism impedes IgG-producing B-cell-mediated tumor elimination by targeting SATB1.
Topics: Adenocarcinoma; Aged; Animals; Azoxymethane; B-Lymphocytes; Cells, Cultured; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Female; Glucose; Humans; Immunoglobulin G; Lung Neoplasms; Male; Matrix Attachment Region Binding Proteins; Mice; Mice, Inbred C57BL; Neoplasms; Promoter Regions, Genetic; RNA, Small Interfering; STAT6 Transcription Factor | 2019 |
Comprehensive analysis of differential circular RNA expression in a mouse model of colitis-induced colon carcinoma.
Topics: Animals; Azoxymethane; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; MAP Kinase Signaling System; Mice; MicroRNAs; RNA; RNA, Circular | 2018 |
Protective Effect of Chickpea Protein Hydrolysates on Colon Carcinogenesis Associated With a Hypercaloric Diet.
Topics: Animals; Azoxymethane; Carcinogenesis; Cicer; Colon; Colonic Neoplasms; Diet; Disease Models, Animal; Energy Intake; Male; Mice; Protective Agents; Protein Hydrolysates; Seeds | 2019 |
The phosphatidic acid phosphatase lipin-1 facilitates inflammation-driven colon carcinogenesis.
Topics: Animals; Azoxymethane; Carcinogenesis; Cell Proliferation; Chemokine CXCL1; Chemokine CXCL2; Colitis; Colon; Colonic Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; Female; Humans; Inflammation; Inflammatory Bowel Diseases; Interleukin-23; Macrophages; Mice; Mice, Inbred BALB C; Mucous Membrane; Nuclear Proteins; Phosphatidate Phosphatase | 2018 |
Dietary Supplementation of Selenoneine-Containing Tuna Dark Muscle Extract Effectively Reduces Pathology of Experimental Colorectal Cancers in Mice.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Azoxymethane; Carcinogenesis; Cell Line, Tumor; Colitis; Colorectal Neoplasms; Dextran Sulfate; Dietary Supplements; Disease Models, Animal; Histidine; Mice; Muscles; Organoselenium Compounds; Spleen; Tuna | 2018 |
A mixture of Persistent Organic Pollutants (POPs) and Azoxymethane (AOM) show potential synergistic effects on intestinal tumorigenesis in the A/J Min/+ mouse model.
Topics: Animals; Azoxymethane; Carcinogenesis; Carcinogens; Colonic Neoplasms; Diet; Disease Models, Animal; Drug Synergism; Environmental Pollutants; Female; Intestines; Liver; Male; Mice; Mice, Inbred A; Organic Chemicals | 2019 |
Folate/Vitamin B12 Supplementation Combats Oxidative Stress-Associated Carcinogenesis in a Rat Model of Colon Cancer.
Topics: Animals; Azoxymethane; Carcinogenesis; Colonic Neoplasms; Dietary Supplements; Disease Models, Animal; Folic Acid; Glutathione; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Vitamin B 12 | 2019 |
Effects of 17β-Estradiol on Colonic Permeability and Inflammation in an Azoxymethane/Dextran Sulfate Sodium-Induced Colitis Mouse Model.
Topics: Animals; Azoxymethane; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Estradiol; Inflammation; Intestinal Mucosa; Kruppel-Like Factor 4; Male; Mice; Mucin-2; Permeability; Signal Transduction; Tight Junctions | 2018 |
Tucum-do-cerrado (Bactris setosa Mart.) modulates oxidative stress, inflammation, and apoptosis-related proteins in rats treated with azoxymethane.
Topics: Animals; Apoptosis; Arecaceae; Azoxymethane; Colon; Colonic Neoplasms; Disease Models, Animal; Fruit; Inflammation; Liver; Male; Oxidative Stress; Phytotherapy; Rats, Wistar | 2018 |
Antibiotics suppress colon tumorigenesis through inhibition of aberrant DNA methylation in an azoxymethane and dextran sulfate sodium colitis model.
Topics: Animals; Anti-Bacterial Agents; Azoxymethane; Cell Transformation, Neoplastic; Colitis, Ulcerative; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; DNA Methylation; Gastrointestinal Microbiome; Humans; Intestinal Mucosa; Male; Mice, Inbred BALB C | 2019 |
Therapeutic effects of lentinan on inflammatory bowel disease and colitis-associated cancer.
Topics: Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Azoxymethane; Carcinoembryonic Antigen; CD30 Ligand; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Female; Gastrointestinal Microbiome; Gene Expression Regulation, Neoplastic; Hyperplasia; Interleukin-13; Keratin-18; Keratin-8; Lentinan; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; NF-kappa B; Signal Transduction; Sulfasalazine; Toll-Like Receptor 4; Tumor Suppressor Protein p53 | 2019 |
Intermittent hypoxia promotes carcinogenesis in azoxymethane and dextran sodium sulfate-induced colon cancer model.
Topics: Animals; Azoxymethane; Carcinogenesis; Carcinogens; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Hypoxia; Inflammation; Male; Mice; Mice, Inbred C57BL; Oxidative Stress | 2019 |
Silibinin Retards Colitis-associated Carcinogenesis by Repression of Cdc25C in Mouse Model.
Topics: Animals; Antineoplastic Agents, Phytogenic; Azoxymethane; Carcinogenesis; Carcinogens; cdc25 Phosphatases; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Male; Mice; Mice, Inbred C57BL; Silybin | 2019 |
The Azoxymethane/Il10
Topics: Animals; Azoxymethane; Colitis; Colorectal Neoplasms; Disease Models, Animal; Germ-Free Life; Inflammation; Inflammatory Bowel Diseases; Interleukin-10; Intestines; Mice, Knockout | 2019 |
Impact of 5 fluorouracil chemotherapy on gut inflammation, functional parameters, and gut microbiota.
Topics: Animals; Azoxymethane; Colitis; Colon; Colonic Neoplasms; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Fecal Microbiota Transplantation; Fluorouracil; Gastrointestinal Microbiome; Inflammation; Male; Mice; Mice, Inbred C57BL | 2019 |
Gum arabic and red propolis protecteting colorectal preneoplastic lesions in a rat model of azoxymethane1.
Topics: Animals; Azoxymethane; Carcinogens; Colorectal Neoplasms; Disease Models, Animal; Gum Arabic; Lysine; Male; Oxidative Stress; Precancerous Conditions; Propolis; Rats; Rats, Wistar | 2019 |
A novel mouse model of sporadic colon cancer induced by combination of conditional Apc genes and chemical carcinogen in the absence of Cre recombinase.
Topics: Adenocarcinoma; Adenoma; Animals; Azoxymethane; Carcinogenesis; Carcinogens; Colonic Neoplasms; Disease Models, Animal; Genes, APC; Integrases; Mice; Mice, Inbred C57BL | 2019 |
Chemopreventive Activity of Red Ginseng Oil in a Mouse Model of Azoxymethane/Dextran Sulfate Sodium-Induced Inflammation-Associated Colon Carcinogenesis.
Topics: Animals; Azoxymethane; Colitis; Colon; Colonic Neoplasms; Cyclooxygenase 2; Dextran Sulfate; Disease Models, Animal; Humans; Interleukin-1beta; Male; Mice; Mice, Inbred C57BL; Panax; Plant Extracts; Tumor Necrosis Factor-alpha | 2019 |
Elevated circulating TGFβ1 during acute liver failure activates TGFβR2 on cortical neurons and exacerbates neuroinflammation and hepatic encephalopathy in mice.
Topics: Animals; Antibodies; Azoxymethane; Benzamides; Carcinogens; Cell Line, Transformed; Cerebral Cortex; Disease Models, Animal; Hepatic Encephalopathy; Inflammation; Isoquinolines; Liver; Liver Failure, Acute; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Neurons; Phagocytosis; Pyrazoles; Pyridines; Pyrroles; Receptor, Transforming Growth Factor-beta Type II; Signal Transduction; Transforming Growth Factor beta1; Up-Regulation | 2019 |
Cancer testis antigen 55 deficiency attenuates colitis-associated colorectal cancer by inhibiting NF-κB signaling.
Topics: Animals; Antigens, Neoplasm; Azoxymethane; Carcinogenesis; Cell Proliferation; Colitis; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; HCT116 Cells; HEK293 Cells; Humans; I-kappa B Kinase; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; NF-kappa B; Phosphorylation; Signal Transduction; Tumor Necrosis Factor-alpha | 2019 |
IL-21 Enhances the Development of Colitis-Associated Colon Cancer: Possible Involvement of Activation-Induced Cytidine Deaminase Expression.
Topics: Animals; Azoxymethane; B-Lymphocytes; Cell Line, Tumor; Colitis; Colonic Neoplasms; Cytidine Deaminase; Dextran Sulfate; Disease Models, Animal; Humans; Immunoglobulin Class Switching; Inflammatory Bowel Diseases; Interleukins; Intestinal Mucosa; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mice, Transgenic | 2019 |
Oct1/Pou2f1 is selectively required for colon regeneration and regulates colon malignancy.
Topics: Animals; Azoxymethane; Carcinogenesis; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Integrases; Intestine, Small; Mice; Mice, Knockout; Neoplastic Stem Cells; Octamer Transcription Factor-1; Organoids; Receptors, G-Protein-Coupled; Regeneration; Signal Transduction; Survival Analysis; Tamoxifen | 2019 |
Preventive Effect of an Infusion of the Aqueous Extract of Chaya Leaves (
Topics: Aberrant Crypt Foci; Animals; Azoxymethane; Colon; Dextran Sulfate; Disease Models, Animal; Euphorbiaceae; Humans; Male; Plant Extracts; Plant Leaves; Protective Agents; Rats; Rats, Sprague-Dawley | 2019 |
Platelet Depletion/Transfusion as a Lethal Factor in a Colitis-associated Cancer Mouse Model.
Topics: Animals; Azoxymethane; Blood Platelets; Carcinogenesis; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Humans; Mice; Mice, Knockout; Platelet Transfusion; Toll-Like Receptor 4 | 2019 |
Interleukin-13 and its signaling pathway is associated with obesity-related colorectal tumorigenesis.
Topics: Aberrant Crypt Foci; Animals; Azoxymethane; Cell Proliferation; Colorectal Neoplasms; Disease Models, Animal; Female; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Interleukin-13; Mice; Mice, Inbred C57BL; Obesity; Peritoneal Absorption; Receptors, Interleukin-13; Signal Transduction; Up-Regulation | 2019 |
Role of Lymphatic Deficiency in the Pathogenesis and Progression of Inflammatory Bowel Disease to Colorectal Cancer in an Experimental Mouse Model.
Topics: Angiopoietin-2; Animals; Azoxymethane; Biomarkers; Colon; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Disease Progression; Female; Inflammatory Bowel Diseases; Lymphangiogenesis; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Tumor Necrosis Factor-alpha | 2019 |
Peptide TNIIIA2 Derived from Tenascin-C Contributes to Malignant Progression in Colitis-Associated Colorectal Cancer via β1-Integrin Activation in Fibroblasts.
Topics: Animals; Azoxymethane; Caco-2 Cells; Cell Proliferation; Colitis; Colonic Polyps; Colorectal Neoplasms; Culture Media, Conditioned; Dextran Sulfate; Disease Models, Animal; Disease Progression; Epithelial Cells; Fibroblasts; Humans; Integrin beta1; Male; Mice, Inbred ICR; Paracrine Communication; Peptides; Tenascin | 2019 |
Oestrogens promote tumorigenesis in a mouse model for colitis-associated cancer.
Topics: Animals; Azoxymethane; Carcinogenesis; Colitis; Colonic Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; Estradiol; Estrogens; Female; Hormone Replacement Therapy; Immunohistochemistry; Medroxyprogesterone; Mice; Ovariectomy | 2014 |
Ay allele promotes azoxymethane-induced colorectal carcinogenesis by macrophage migration in hyperlipidemic/diabetic KK mice.
Topics: Alleles; Animals; Azoxymethane; beta Catenin; Carcinogenesis; Cell Movement; Cocarcinogenesis; Colorectal Neoplasms; Diabetes Mellitus, Type 2; Disease Models, Animal; Female; Hyperlipidemias; Inflammation; Insulin; Macrophages; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Inbred NOD; RNA, Messenger; Triglycerides | 2013 |
RNase-L deficiency exacerbates experimental colitis and colitis-associated cancer.
Topics: Animals; Azoxymethane; Blotting, Western; Carcinogens; Colitis; Colonic Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; Endoribonucleases; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Immunity, Innate; Immunoenzyme Techniques; Interferon Type I; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Peroxidase; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction | 2013 |
Colitis-accelerated colorectal cancer and metabolic dysregulation in a mouse model.
Topics: Animals; Apoptosis; Azoxymethane; Carcinogens; Colitis; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Female; Inflammation; Metabolic Diseases; Mice; Mice, Inbred BALB C; MicroRNAs; RNA, Messenger; Transcriptome; Up-Regulation; Wnt Proteins | 2013 |
Suppressive effect of RAS inhibitor manumycin A on aberrant crypt foci formation in the azoxymethane-induced rat colorectal carcinogenesis model.
Topics: Aberrant Crypt Foci; Animals; Apoptosis; Azoxymethane; Colorectal Neoplasms; Disease Models, Animal; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Farnesyltranstransferase; Genes, ras; Injections, Subcutaneous; Ki-67 Antigen; Mutation; Phosphorylation; Polyenes; Polyunsaturated Alkamides; ras Proteins; Rats; Rats, Inbred F344 | 2013 |
Utility of a bacterial infection model to study epithelial-mesenchymal transition, mesenchymal-epithelial transition or tumorigenesis.
Topics: Animals; Azoxymethane; Bacterial Infections; Carcinogenesis; Cell Differentiation; Colon; Disease Models, Animal; Epigenesis, Genetic; Epithelial-Mesenchymal Transition; Mice; Mice, Nude; Receptors, Notch; Signal Transduction; Stem Cells; Wnt Proteins | 2014 |
Raman endoscopy for the in situ investigation of advancing colorectal tumors in live model mice.
Topics: Age Factors; Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Disease Progression; Mice; Mice, Inbred BALB C; Spectrum Analysis, Raman | 2013 |
Intestine-Specific Mttp Deletion Increases the Severity of Experimental Colitis and Leads to Greater Tumor Burden in a Model of Colitis Associated Cancer.
Topics: Animals; Azoxymethane; Carrier Proteins; Cells, Cultured; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Feces; Interleukin-17; Interleukin-1beta; Intestines; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myofibroblasts; Severity of Illness Index; Tumor Burden; Tumor Necrosis Factor-alpha | 2013 |
Lipopolysaccharide precipitates hepatic encephalopathy and increases blood-brain barrier permeability in mice with acute liver failure.
Topics: Ammonia; Animals; Azoxymethane; Blood-Brain Barrier; Cytokines; Disease Models, Animal; Hepatic Encephalopathy; Inflammation; Lipopolysaccharides; Liver; Liver Failure, Acute; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Permeability; Transaminases | 2014 |
Nano-architectural alterations in mucus layer fecal colonocytes in field carcinogenesis: potential for screening.
Topics: Adenoma; Animals; Azoxymethane; Carcinogenesis; Colon; Colonoscopy; Colorectal Neoplasms; Disease Models, Animal; Early Detection of Cancer; Endoscopy; Feces; Intestinal Mucosa; Male; Mass Screening; Microscopy; Occult Blood; Optics and Photonics; Rats; Rats, Inbred F344 | 2013 |
Comparing the effects of COX and non-COX-inhibiting NSAIDs on enhancement of apoptosis and inhibition of aberrant crypt foci formation in a rat colorectal cancer model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Azoxymethane; Colorectal Neoplasms; Cyclooxygenase Inhibitors; Disease Models, Animal; Flurbiprofen; Male; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Sulindac | 2013 |
Panax notoginseng attenuates experimental colitis in the azoxymethane/dextran sulfate sodium mouse model.
Topics: Animals; Azoxymethane; Colitis; Colon; Cyclooxygenase 2; Dextran Sulfate; Disease Models, Animal; Male; Mice; Nitric Oxide Synthase Type II; Panax notoginseng; Plant Extracts; Saponins | 2014 |
The importance of the retinoid X receptor alpha in modulating inflammatory signaling in acute murine colitis.
Topics: Animals; Azoxymethane; Carcinogens; Colitis; Dextran Sulfate; Disease Models, Animal; Down-Regulation; Heterozygote; Immunoblotting; Inflammation; Mice; Receptors, Calcitriol; Retinoid X Receptor alpha | 2014 |
Characterization of hERG1 channel role in mouse colorectal carcinogenesis.
Topics: Adenomatous Polyposis Coli; Animals; Azoxymethane; Carcinogenesis; Carcinogens; Colorectal Neoplasms; Disease Models, Animal; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Gene Expression Regulation, Neoplastic; Humans; Intestinal Mucosa; Intestine, Large; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neoplasm Proteins; Neovascularization, Pathologic; Piperidines; Proto-Oncogene Proteins c-akt; Pyridines; Vascular Endothelial Growth Factor A | 2013 |
Biomarkers of coordinate metabolic reprogramming in colorectal tumors in mice and humans.
Topics: Animals; Azoxymethane; Biomarkers, Tumor; Cell Proliferation; Chromatography, Reverse-Phase; Colorectal Neoplasms; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, APC; High-Throughput Screening Assays; Humans; Metabolomics; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neoplasm Staging; Predictive Value of Tests; Protein Interaction Mapping; Protein Interaction Maps; Real-Time Polymerase Chain Reaction; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization | 2014 |
Identification of a microRNA landscape targeting the PI3K/Akt signaling pathway in inflammation-induced colorectal carcinogenesis.
Topics: Animals; Azoxymethane; Carcinogenesis; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction | 2014 |
Azoxymethane-induced colon carcinogenesis in mice occurs independently of de novo thymidylate synthesis capacity.
Topics: Animals; Azoxymethane; Carcinogenesis; Choline Deficiency; Colon; Colonic Neoplasms; Crosses, Genetic; Disease Models, Animal; DNA; Extracellular Matrix Proteins; Folic Acid; Folic Acid Deficiency; Glycine Hydroxymethyltransferase; Male; Mice; Mice, Knockout; Mice, Transgenic; Neoplasm Proteins; Protein-Lysine 6-Oxidase; Random Allocation; Thymidine Monophosphate; Tumor Burden; Uracil | 2014 |
MyD88 adaptor-like (Mal) regulates intestinal homeostasis and colitis-associated colorectal cancer in mice.
Topics: Animals; Azoxymethane; Bone Marrow Transplantation; Caco-2 Cells; Colitis; Colon; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Female; Homeostasis; Humans; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Interleukin-1; Severity of Illness Index; Time Factors; Transplantation Chimera | 2014 |
Inhibition of beta-catenin and KRAS expressions by Piper betle in azoxymethane-induced colon cancer of male Fischer 344 rats.
Topics: Animals; Azoxymethane; beta Catenin; Carcinogens; Colonic Neoplasms; Disease Models, Animal; Immunohistochemistry; Male; Phytotherapy; Piper betle; Plant Extracts; Plant Leaves; Precancerous Conditions; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); ras Proteins; Rats; Rats, Inbred F344 | 2013 |
Chemopreventive evaluation of a Schiff base derived copper (II) complex against azoxymethane-induced colorectal cancer in rats.
Topics: Aberrant Crypt Foci; Animals; Azoxymethane; Blood Chemical Analysis; Body Weight; Carcinogens; Chemoprevention; Colorectal Neoplasms; Copper; Disease Models, Animal; Female; Kidney; Liver; Male; Oxidation-Reduction; Proliferating Cell Nuclear Antigen; Rats; Schiff Bases; Toxicity Tests, Acute | 2014 |
Copper metabolism domain-containing 1 represses genes that promote inflammation and protects mice from colitis and colitis-associated cancer.
Topics: Adaptor Proteins, Signal Transducing; Animals; Azoxymethane; Biopsy; Case-Control Studies; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Humans; Inflammation; Inflammatory Bowel Diseases; Mice; Mice, Knockout; NF-kappa B; Polymorphism, Single Nucleotide; RNA, Messenger | 2014 |
Identification of gene expression changes from colitis to CRC in the mouse CAC model.
Topics: Animals; Azoxymethane; Colitis; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Female; Gene Expression Regulation, Neoplastic; Genome-Wide Association Study; Mice; Mice, Inbred BALB C; Protein Binding | 2014 |
Dynamic microbe and molecule networks in a mouse model of colitis-associated colorectal cancer.
Topics: Animals; Azoxymethane; Colitis; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Tract; Inflammation; Male; Mice; Mice, Inbred BALB C; RNA, Ribosomal, 16S | 2014 |
Nuclear adenomatous polyposis coli suppresses colitis-associated tumorigenesis in mice.
Topics: Adenomatous Polyposis Coli Protein; Animals; Apoptosis; Azoxymethane; beta Catenin; Blotting, Western; Carcinogens; Cell Nucleus; Cell Proliferation; Cell Transformation, Neoplastic; Colitis; Colorectal Neoplasms; Cyclooxygenase 2; Dextran Sulfate; Disease Models, Animal; Inflammation; Mice; Mutation; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction | 2014 |
[Chemo-preventive effect of Angelica sinensis' supercritical extracts on AOM/DSS-induced mouse colorectal carcinoma associated with inflammation].
Topics: Angelica sinensis; Animals; Azoxymethane; Colonic Neoplasms; Colorectal Neoplasms; Cyclooxygenase 2; Dextran Sulfate; Disease Models, Animal; Drugs, Chinese Herbal; Humans; Male; Mice; Mice, Inbred BALB C; Proliferating Cell Nuclear Antigen | 2014 |
Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline.
Topics: Animals; Azoxymethane; Benzamides; Body Temperature; Body Weight; Carcinogens; Chemokine CCL2; Disease Models, Animal; Enzyme Inhibitors; Glycine; Hepatic Encephalopathy; Liver; Male; Mice; Mice, Inbred C57BL; Microglia; Nervous System Diseases; Quinazolines; Signal Transduction; Time Factors; Up-Regulation | 2014 |
The role of corticotropin-releasing hormone receptor 1 in the development of colitis-associated cancer in mouse model.
Topics: Animals; Azoxymethane; Colitis; Colon; Colonic Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; Female; Humans; Male; Mice, Knockout; NF-kappa B; Receptors, Corticotropin-Releasing Hormone; STAT3 Transcription Factor | 2014 |
Lactoferrin deficiency promotes colitis-associated colorectal dysplasia in mice.
Topics: Animals; Apoptosis; Azoxymethane; Cell Proliferation; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Down-Regulation; Gene Knockout Techniques; Humans; Inflammation; Lactoferrin; Male; Mice; NF-kappa B; Signal Transduction | 2014 |
[Inflammation promotes the development of colitis-associated colorectal cancer].
Topics: Animals; Azoxymethane; Colitis; Colonic Neoplasms; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Immunohistochemistry; Inflammation; Interleukin-6; Mice; Mice, Inbred C57BL; Signal Transduction; STAT3 Transcription Factor; Tumor Necrosis Factor-alpha | 2014 |
Role of inflammation and inflammatory mediators in colorectal cancer.
Topics: Adenoma; Animals; Azoxymethane; Colitis; Colon; Colorectal Neoplasms; Cyclooxygenase 2; Dextran Sulfate; Dinoprostone; Disease Models, Animal; Genes, APC; Humans; Inflammation Mediators; Intestinal Mucosa; Mice, Inbred BALB C; Mice, Knockout; Rats; Receptors, Interleukin-8B | 2014 |
Activation of the mTORC1 and STAT3 pathways promotes the malignant transformation of colitis in mice.
Topics: Animals; Antineoplastic Agents; Azoxymethane; Cell Transformation, Neoplastic; Colitis; Colorectal Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; Female; Gene Expression Regulation, Neoplastic; Humans; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred C57BL; Multiprotein Complexes; Signal Transduction; Sirolimus; STAT3 Transcription Factor; TOR Serine-Threonine Kinases | 2014 |
Aldose reductase inhibition suppresses azoxymethane-induced colonic premalignant lesions in C57BL/KsJ-db/db mice.
Topics: Aldehyde Reductase; Animals; Anticarcinogenic Agents; Azoxymethane; Colon; Colonic Neoplasms; Diabetes Mellitus, Type 2; Disease Models, Animal; Enzyme Inhibitors; HT29 Cells; Humans; Imidazolidines; Inflammation Mediators; Intestinal Mucosa; Male; Mice, Inbred C57BL; Obesity; Oxidative Stress; Precancerous Conditions; Signal Transduction | 2014 |
Nicotine suppresses acute colitis and colonic tumorigenesis associated with chronic colitis in mice.
Topics: Acute Disease; alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Azoxymethane; CD4-Positive T-Lymphocytes; Chronic Disease; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Down-Regulation; Gastrointestinal Agents; Inflammation Mediators; Interleukin-6; Intestinal Mucosa; Male; Mice, Inbred BALB C; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; RNA, Messenger; Severity of Illness Index; STAT3 Transcription Factor; Time Factors; Tumor Necrosis Factor-alpha | 2014 |
Sex disparity in colonic adenomagenesis involves promotion by male hormones, not protection by female hormones.
Topics: Adenoma; Adenomatous Polyposis Coli; Animals; Animals, Congenic; Azoxymethane; Carcinogens; Colonic Neoplasms; Dihydrotestosterone; Disease Models, Animal; Estradiol; Female; Genes, APC; Gonadal Steroid Hormones; Hormone Replacement Therapy; Humans; Male; Medroxyprogesterone Acetate; Mice; Mice, Inbred C57BL; Mutation; Neoplasms, Hormone-Dependent; Orchiectomy; Organ Specificity; Ovariectomy; Postmenopause; Random Allocation; Rats; Rats, Inbred F344; Rats, Mutant Strains; Receptors, Androgen; RNA, Messenger; Sex Distribution; Species Specificity | 2014 |
Grape juice concentrate (G8000™) modulates apoptosis but not oxidative stress following rat colon carcinogenesis induced by azoxymethane.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; bcl-2-Associated X Protein; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Deoxyguanosine; Disease Models, Animal; Fruit; Fruit and Vegetable Juices; Male; Oxidative Stress; Phytotherapy; Plants, Medicinal; Proto-Oncogene Proteins c-bcl-2; Rats, Wistar; Time Factors; Vitis | 2015 |
Dynamic changes and functions of macrophages and M1/M2 subpopulations during ulcerative colitis-associated carcinogenesis in an AOM/DSS mouse model.
Topics: Animals; Azoxymethane; Biomarkers; Carcinoma; Cell Transformation, Neoplastic; Colitis, Ulcerative; Colonic Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; Gene Expression; Hyperplasia; Inflammation Mediators; Macrophages; Male; Mice; Neoplasm Metastasis | 2015 |
Effect of genetic deletion or pharmacological antagonism of tumor necrosis factor alpha on colitis-associated carcinogenesis in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; Etanercept; Female; Mice; Mice, Knockout; NF-kappa B; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha | 2015 |
Role of milk fat globule-epidermal growth factor 8 in colonic inflammation and carcinogenesis.
Topics: Animals; Antigens, Surface; Azoxymethane; Body Weight; Cell Proliferation; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Epithelial Cells; Humans; Integrin alphaVbeta3; Intestinal Mucosa; Mice, Knockout; Milk Proteins; Neoplasm Proteins; Recombinant Proteins; Tumor Cells, Cultured | 2015 |
Induction of colorectal cancer in mice and histomorphometric evaluation of tumors.
Topics: Animals; Azoxymethane; Colorectal Neoplasms; Disease Models, Animal; Eosine Yellowish-(YS); Hematoxylin; Humans; Immunohistochemistry; Mice; Receptors, Platelet-Derived Growth Factor; S100 Calcium-Binding Protein A4; S100 Proteins; Software; Staining and Labeling; Sulfates; Tumor Burden | 2015 |
NF-κB1, NF-κB2 and c-Rel differentially regulate susceptibility to colitis-associated adenoma development in C57BL/6 mice.
Topics: Adenoma; Animals; Azoxymethane; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; Disease Susceptibility; Epithelial Cells; Female; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B p50 Subunit; NF-kappa B p52 Subunit; Proto-Oncogene Proteins c-rel; Signal Transduction | 2015 |
SPINK1 Status in Colorectal Cancer, Impact on Proliferation, and Role in Colitis-Associated Cancer.
Topics: Aged; Animals; Azoxymethane; Carrier Proteins; Cell Line, Tumor; Cell Proliferation; Colitis; Colonic Neoplasms; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Female; Glycoproteins; Humans; Inflammation; Japan; Male; Mice, Inbred C57BL; Middle Aged; Prostatic Secretory Proteins; Trypsin Inhibitor, Kazal Pancreatic | 2015 |
NPC1L1 knockout protects against colitis-associated tumorigenesis in mice.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azoxymethane; beta Catenin; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Homozygote; Intestinal Mucosa; Lipids; Membrane Transport Proteins; Mice; Mice, Knockout; Transforming Growth Factor beta; Tumor Suppressor Protein p53 | 2015 |
Mesenchymal stem cells-regulated Treg cells suppress colitis-associated colorectal cancer.
Topics: Animals; Azoxymethane; CD4 Lymphocyte Count; Cell Differentiation; Cell Line; Cell Movement; Cell- and Tissue-Based Therapy; Colitis; Colon; Colorectal Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; Humans; Inflammation; Jurkat Cells; Lymphocyte Activation; Lymphocyte Count; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Signal Transduction; Smad2 Protein; T-Lymphocytes, Regulatory; Th17 Cells; Th2 Cells; Umbilical Cord | 2015 |
Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis.
Topics: Adenocarcinoma; Animals; Azoxymethane; Bacteroides fragilis; Blotting, Western; Carcinogenesis; Carcinogens; Cell Line, Tumor; Cell Proliferation; Chemokine CCL20; Colitis; Colonic Neoplasms; Dextran Sulfate; Dinoprostone; Disease Models, Animal; Enterobacteriaceae; Exosomes; Immunohistochemistry; In Situ Hybridization, Fluorescence; Inflammation; Intestinal Mucosa; Lysophospholipids; Mice; Myeloid Differentiation Factor 88; Nanoparticles; Neoplasm Transplantation; Reverse Transcriptase Polymerase Chain Reaction; Sphingosine; Th17 Cells | 2015 |
Smad2/3 linker phosphorylation is a possible marker of cancer stem cells and correlates with carcinogenesis in a mouse model of colitis-associated colorectal cancer.
Topics: Animals; Azoxymethane; beta Catenin; Biomarkers, Tumor; Carcinogenesis; Colitis; Colorectal Neoplasms; Cyclin D1; Dextran Sulfate; Disease Models, Animal; Ki-67 Antigen; Male; Mice; Neoplastic Stem Cells; Phosphorylation; Proto-Oncogene Proteins c-myc; Serine; Signal Transduction; Smad2 Protein; Smad3 Protein; SOX9 Transcription Factor | 2015 |
HIC1 Tumor Suppressor Loss Potentiates TLR2/NF-κB Signaling and Promotes Tissue Damage-Associated Tumorigenesis.
Topics: Animals; Azoxymethane; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Epithelial Cells; Gene Knockdown Techniques; Humans; Intestines; Kruppel-Like Transcription Factors; Mice; Mice, Transgenic; NF-kappa B; Signal Transduction; Toll-Like Receptor 2; Tumor Suppressor Proteins; Up-Regulation | 2015 |
MicroRNA214 Is Associated With Progression of Ulcerative Colitis, and Inhibition Reduces Development of Colitis and Colitis-Associated Cancer in Mice.
Topics: Adaptor Proteins, Signal Transducing; Animals; Azoxymethane; Biomarkers, Tumor; Case-Control Studies; Cell Line; Colitis, Ulcerative; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Disease Progression; Gene Expression Regulation, Neoplastic; Humans; Inflammation Mediators; Interleukin-6; LIM Domain Proteins; Mice; MicroRNAs; NF-kappa B; Phosphorylation; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; RNA Interference; RNAi Therapeutics; Signal Transduction; STAT3 Transcription Factor; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 2015 |
St. John's Wort Attenuates Colorectal Carcinogenesis in Mice through Suppression of Inflammatory Signaling.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Carcinogenesis; Cell Transformation, Neoplastic; Colon; Colorectal Neoplasms; Diet; Dietary Supplements; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Hypericum; Inflammation; Male; Mice; NF-kappa B; Oligonucleotide Array Sequence Analysis; Oligonucleotides; Plant Extracts; Signal Transduction | 2015 |
Calpain-2 Inhibitor Therapy Reduces Murine Colitis and Colitis-associated Cancer.
Topics: Animals; Azoxymethane; Cell Proliferation; Colitis; Colonic Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; HT29 Cells; Humans; I-kappa B Proteins; Inflammation; Injections, Intraperitoneal; Macrophage Activation; Mice; NF-kappa B; Oligopeptides; Translocation, Genetic | 2015 |
Ghrelin administration suppresses inflammation-associated colorectal carcinogenesis in mice.
Topics: Animals; Azoxymethane; Carcinogenesis; Carcinogens; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Ghrelin; Inflammation; Male; Mice; Mice, Inbred C57BL | 2015 |
The MUTYH base excision repair gene protects against inflammation-associated colorectal carcinogenesis.
Topics: Adenocarcinoma; Adenoma; Animals; Azoxymethane; Bone Marrow Cells; CD8-Positive T-Lymphocytes; Cell Transformation, Neoplastic; Colitis; Colon; Colorectal Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; DNA Glycosylases; Forkhead Transcription Factors; Guanine; Inflammation Mediators; Mice, Knockout; T-Lymphocytes, Regulatory; Time Factors | 2015 |
FGF-1/-3/FGFR4 signaling in cancer-associated fibroblasts promotes tumor progression in colon cancer through Erk and MMP-7.
Topics: Animals; Azoxymethane; Cell Line, Tumor; Colitis, Ulcerative; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Disease Progression; Extracellular Signal-Regulated MAP Kinases; Fibroblast Growth Factor 1; Fibroblast Growth Factor 3; Fibroblasts; HCT116 Cells; HT29 Cells; Human Umbilical Vein Endothelial Cells; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 7; Mice; Phosphorylation; Pyrimidines; Receptor Protein-Tyrosine Kinases; Receptor, Fibroblast Growth Factor, Type 4; Receptors, Fibroblast Growth Factor; RNA Interference; RNA, Small Interfering | 2015 |
The Role of Curcumin in Modulating Colonic Microbiota During Colitis and Colon Cancer Prevention.
Topics: Animals; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colitis; Colon; Colorectal Neoplasms; Curcumin; Dietary Supplements; Disease Models, Animal; Immunity, Mucosal; Intestinal Mucosa; Mice; Mice, 129 Strain; Mice, Knockout; Microbiota | 2015 |
Chemoprevention of Azoxymethane-induced Colonic Carcinogenesis in Balb/c mice Using a Modified Pectin Alginate Probiotic.
Topics: Alginates; Animals; Azoxymethane; Carcinogenesis; Chemoprevention; Colon; Colonic Neoplasms; Disease Models, Animal; Galectins; Glucuronic Acid; Hexuronic Acids; Immunohistochemistry; Male; Mice, Inbred BALB C; Pectins; Probiotics; Vascular Endothelial Growth Factor A | 2015 |
Brewers' rice modulates oxidative stress in azoxymethane-mediated colon carcinogenesis in rats.
Topics: Animals; Antioxidants; Azoxymethane; beta Catenin; Carcinogenesis; Colon; Colonic Neoplasms; Dietary Supplements; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Heme Oxygenase (Decyclizing); Male; Malondialdehyde; NF-E2-Related Factor 2; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Oryza; Oxidative Stress; Plant Preparations; Rats, Sprague-Dawley; Superoxide Dismutase; Transcription, Genetic; Transcriptional Activation; Wnt Signaling Pathway | 2015 |
M1 Muscarinic Receptor Deficiency Attenuates Azoxymethane-Induced Chronic Liver Injury in Mice.
Topics: Acute Disease; Animals; Apoptosis; Azoxymethane; Bile Ducts; Cell Survival; Disease Models, Animal; Fibrosis; Hepatic Stellate Cells; Hepatocytes; Hyperplasia; Liver Diseases; Matrix Metalloproteinases; Mice; Mice, Knockout; Oxidative Stress; Receptor, Muscarinic M1; Tissue Inhibitor of Metalloproteinases | 2015 |
Thrombospondin-1 in a Murine Model of Colorectal Carcinogenesis.
Topics: Animals; Azoxymethane; Carcinogenesis; Cell Proliferation; Colon; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Down-Regulation; Gene Expression Regulation, Neoplastic; Genes, Neoplasm; Immunohistochemistry; Inflammation; Mice, Inbred C57BL; Microvessels; Reproducibility of Results; RNA, Messenger; Thrombospondin 1; Up-Regulation | 2015 |
Chemopreventive activity of grape juice concentrate (G8000TM) on rat colon carcinogenesis induced by azoxymethane.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Cyclooxygenase 2; Disease Models, Animal; Fruit and Vegetable Juices; Gene Expression Regulation, Neoplastic; Ki-67 Antigen; Male; Plant Extracts; Rats; Rats, Wistar; Vitis | 2015 |
Suppression of colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway by balsalazide and VSL#3.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Azoxymethane; bcl-2-Associated X Protein; Cell Transformation, Neoplastic; Colitis; Colon; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Agents; Inflammation Mediators; Interleukin-6; Macrophages; Male; Mesalamine; Mice, Inbred C57BL; Phenylhydrazines; Phosphorylation; Probiotics; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; STAT3 Transcription Factor; Time Factors | 2016 |
Hydrolysed inulin alleviates the azoxymethane-induced preneoplastic aberrant crypt foci by altering selected intestinal microbiota in Sprague-Dawley rats.
Topics: Aberrant Crypt Foci; Animals; Anticarcinogenic Agents; Azoxymethane; Bacteria; Bacterial Load; Biomass; Colon; Colonic Neoplasms; Disease Models, Animal; Gastrointestinal Microbiome; Hydrolysis; Inulin; Male; Rats, Sprague-Dawley; Time Factors | 2016 |
The Innate Immune Receptor NLRX1 Functions as a Tumor Suppressor by Reducing Colon Tumorigenesis and Key Tumor-Promoting Signals.
Topics: Adenomatous Polyposis Coli Protein; Animals; Antibodies, Monoclonal, Humanized; Azoxymethane; Biomarkers, Tumor; Carcinogenesis; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Humans; Interleukin-6; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Fluorescence; Mitochondrial Proteins; Mitogen-Activated Protein Kinases; NF-kappa B; Real-Time Polymerase Chain Reaction; Signal Transduction; STAT3 Transcription Factor | 2016 |
[Changes of macrophages in colitis-associated colonic carcinogenesis].
Topics: Animals; Azoxymethane; Carcinogenesis; Carcinogens; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Granulocyte Colony-Stimulating Factor; Macrophages; Mice; Mice, Inbred C57BL; Phenotype; Real-Time Polymerase Chain Reaction | 2016 |
Paricalcitol Enhances the Chemopreventive Efficacy of 5-Fluorouracil on an Intermediate-Term Model of Azoxymethane-Induced Colorectal Tumors in Rats.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Azoxymethane; Blotting, Western; Carcinogens; Colorectal Neoplasms; Disease Models, Animal; Ergocalciferols; Fluorouracil; Immunohistochemistry; Male; Polymerase Chain Reaction; Rats; Rats, Wistar; Transcriptome | 2016 |
Vancomycin-sensitive bacteria trigger development of colitis-associated colon cancer by attracting neutrophils.
Topics: Animals; Azoxymethane; Bacteria; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; DNA Damage; Gene Expression Regulation; Humans; Mice; Neutrophils; Vancomycin | 2016 |
Acute blockade of IL-25 in a colitis associated colon cancer model leads to increased tumor burden.
Topics: Animals; Antibodies, Neutralizing; Azoxymethane; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Eosinophils; Gene Deletion; Gene Expression Regulation; Interleukin-17; Mice, Inbred BALB C; Tumor Burden | 2016 |
AOM/DSS Model of Colitis-Associated Cancer.
Topics: Animals; Azoxymethane; Colitis; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Humans; Mice | 2016 |
Hypocholesterolemic and Anticarcinogenic Effect of Vicia faba Protein Hydrolyzates.
Topics: Aberrant Crypt Foci; Animals; Anticarcinogenic Agents; Antioxidants; Azoxymethane; Cholesterol, Dietary; Colorectal Neoplasms; Diet; Disease Models, Animal; Male; Mice; Mice, Inbred ICR; Plant Extracts; Protein Hydrolysates; Vicia faba | 2016 |
Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth.
Topics: Adenocarcinoma; Animals; Azoxymethane; Bone Morphogenetic Proteins; Carcinogenesis; Cell Proliferation; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Down-Regulation; Gene Expression Regulation, Neoplastic; Hedgehog Proteins; Integrases; Mice, Inbred C57BL; Recombination, Genetic; Signal Transduction; Stromal Cells; Transcription, Genetic; Tumor Burden | 2016 |
In vivo endoscopic Doppler optical coherence tomography imaging of the colon.
Topics: Adenocarcinoma; Animals; Azoxymethane; Colonic Neoplasms; Disease Models, Animal; Endosonography; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Sensitivity and Specificity; Tomography, Optical Coherence | 2017 |
Protective effects of Huangqin Decoction against ulcerative colitis and associated cancer in mice.
Topics: Animals; Antioxidants; Azoxymethane; Chromatography, High Pressure Liquid; Colitis, Ulcerative; Colorectal Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; Drugs, Chinese Herbal; Flavanones; Inflammation; Male; Medicine, Chinese Traditional; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Oxidative Stress; Plant Extracts; Scutellaria baicalensis | 2016 |
Fractalkine suppression during hepatic encephalopathy promotes neuroinflammation in mice.
Topics: Alanine Transaminase; Animals; Azoxymethane; Bilirubin; Calcium-Binding Proteins; Carcinogens; Cerebral Cortex; Chemokine CX3CL1; Cytokines; Disease Models, Animal; Down-Regulation; Encephalitis; Flow Cytometry; Hepatic Encephalopathy; Infusions, Intraventricular; Male; Mice; Mice, Inbred C57BL; Microfilament Proteins; Neuroglia; Phosphopyruvate Hydratase | 2016 |
Flavonoids Extracted from Licorice Prevents Colitis-Associated Carcinogenesis in AOM/DSS Mouse Model.
Topics: Animals; Apoptosis; Azoxymethane; Carcinogenesis; Cell Proliferation; Colitis; Dextran Sulfate; Disease Models, Animal; Female; Flavonoids; Glycyrrhiza; Inflammatory Bowel Diseases; Interleukin-6; Janus Kinase 2; Mice; Mice, Inbred C57BL; NF-kappa B; Signal Transduction; STAT3 Transcription Factor; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53 | 2016 |
The role of Ly49E receptor expression on murine intraepithelial lymphocytes in intestinal cancer development and progression.
Topics: Adenomatous Polyposis Coli Protein; Animals; Azoxymethane; Carcinogenesis; Carcinoma in Situ; Disease Models, Animal; Epithelium; Gene Expression Regulation, Neoplastic; Immunity, Cellular; Intestinal Neoplasms; Lymphocytes; Mice; Mice, Inbred Strains; Mice, Knockout; NK Cell Lectin-Like Receptor Subfamily A; Tumor Burden; Urokinase-Type Plasminogen Activator | 2016 |
Weight loss following diet-induced obesity does not alter colon tumorigenesis in the AOM mouse model.
Topics: Animals; Azoxymethane; Body Weight; Carcinogenesis; Cell Proliferation; Colon; Colonic Neoplasms; Diet, High-Fat; Disease Models, Animal; Liver; Liver Neoplasms; Macrophages; Mice; Obesity; T-Lymphocytes; Weight Loss | 2016 |
Prevention of azoxymethane/dextran sodium sulfate-induced mouse colon carcinogenesis by processed Aloe vera gel.
Topics: Adenocarcinoma; Aloe; Animals; Azoxymethane; Carcinogenesis; CDX2 Transcription Factor; Cell Cycle; Colitis; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Female; Gels; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Inbred BALB C; NF-kappa B; Plant Extracts; Tumor Suppressor Proteins | 2016 |
Daikenchuto (TU-100) Suppresses Tumor Development in the Azoxymethane and APC
Topics: Animals; Azoxymethane; Colonic Neoplasms; Disease Models, Animal; Male; Medicine, Traditional; Mice; Panax; Plant Extracts; Zanthoxylum; Zingiberaceae | 2017 |
A role for the vitamin D pathway in non-intestinal lesions in genetic and carcinogen models of colorectal cancer and in familial adenomatous polyposis.
Topics: Adenocarcinoma; Adenomatous Polyposis Coli; Animals; Azoxymethane; beta Catenin; Cell Transformation, Neoplastic; Colorectal Neoplasms; Disease Models, Animal; Disease Progression; Gardner Syndrome; Genes, APC; Genetic Predisposition to Disease; Mice, Inbred C57BL; Mice, Knockout; Mutation; Phenotype; Polymorphism, Single Nucleotide; Receptors, Calcitriol; Risk Factors; Time Factors; Vitamin D; Wnt Signaling Pathway | 2016 |
Oral administration of a recombinant cholera toxin B subunit promotes mucosal healing in the colon.
Topics: Administration, Oral; Animals; Azoxymethane; Caco-2 Cells; Cholera; Cholera Toxin; Cholera Vaccines; Colitis, Ulcerative; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Female; Humans; Mice; Mice, Inbred C57BL; Mucous Membrane; Signal Transduction; Transforming Growth Factor beta; Wound Healing | 2017 |
The role of Pygo2 for Wnt/ß-catenin signaling activity during intestinal tumor initiation and progression.
Topics: Adenoma; Animals; Azoxymethane; beta Catenin; Cell Proliferation; Cell Transformation, Neoplastic; Colonic Neoplasms; Disease Models, Animal; Disease Progression; Gene Expression Regulation, Neoplastic; Genes, APC; Genetic Predisposition to Disease; Intracellular Signaling Peptides and Proteins; Mice, Inbred C57BL; Mice, Knockout; Mutation; Phenotype; Proto-Oncogene Proteins c-myc; Time Factors; Tumor Burden; Wnt Signaling Pathway | 2016 |
T lymphocyte SHP2-deficiency triggers anti-tumor immunity to inhibit colitis-associated cancer in mice.
Topics: Animals; Azoxymethane; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cells, Cultured; Colitis; Colonic Neoplasms; Cytotoxicity, Immunologic; Dextran Sulfate; Disease Models, Animal; Fas Ligand Protein; Granzymes; Inflammation Mediators; Interferon-gamma; Lymphocytes, Tumor-Infiltrating; Mice, Knockout; Perforin; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Signal Transduction; STAT1 Transcription Factor; Time Factors; Tumor Microenvironment | 2017 |
Daily Intake of High-Fat Diet with Lysophosphatidic Acid-Rich Soybean Phospholipids Augments Colon Tumorigenesis in Kyoto Apc Delta Rats.
Topics: Animals; Azoxymethane; Carcinogenesis; Carcinogens; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Complex Mixtures; Dextran Sulfate; Diet, High-Fat; Disease Models, Animal; Dose-Response Relationship, Drug; Food-Drug Interactions; Glycine max; Intestinal Mucosa; Lysophospholipids; Rats; Statistics as Topic | 2017 |
RNA virus receptor Rig-I monitors gut microbiota and inhibits colitis-associated colorectal cancer.
Topics: Animals; Azoxymethane; Bacteria; Colitis; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; DNA, Bacterial; Down-Regulation; Gastrointestinal Microbiome; Humans; Immunoglobulin A; Interleukin-6; Membrane Proteins; Mice; Nerve Tissue Proteins; Pancreatitis-Associated Proteins; Phosphorylation; Phylogeny; Receptors, Cell Surface; Receptors, Retinoic Acid; Sequence Analysis, DNA; STAT3 Transcription Factor | 2017 |
WD-repeat protein WDR13 is a novel transcriptional regulator of c-Jun and modulates intestinal homeostasis in mice.
Topics: Animals; Azoxymethane; Cell Cycle Proteins; Cell Line; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Gene Expression Regulation, Neoplastic; HEK293 Cells; Homeostasis; HT29 Cells; Humans; MCF-7 Cells; Mice; Nuclear Proteins; Proto-Oncogene Proteins c-jun; Signal Transduction | 2017 |
Exploration of Inflammatory Bowel Disease in Mice: Chemically Induced Murine Models of Inflammatory Bowel Disease (IBD).
Topics: Acute Disease; Animals; Azoxymethane; Cell Transformation, Neoplastic; Chronic Disease; Colitis; Dextran Sulfate; Disease Models, Animal; Humans; Inflammatory Bowel Diseases; Mice; Trinitrobenzenesulfonic Acid | 2017 |
Tumor necrosis factor alpha and colitis-associated colon cancer.
Topics: Animals; Azoxymethane; Chronic Disease; Colitis, Ulcerative; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Etanercept; Humans; Immunoglobulin G; Mice; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2008 |
Effects of combination of calcium and aspirin on azoxymethane-induced aberrant crypt foci formation in the colons of mice and rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Azoxymethane; Calcium, Dietary; Carcinogens; Colon; Colonic Neoplasms; Dietary Fats; Disease Models, Animal; Drug Therapy, Combination; Female; Male; Mice; Rats | 2008 |
A novel prodrug of 4'-geranyloxy-ferulic acid suppresses colitis-related colon carcinogenesis in mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adenocarcinoma; Animals; Anticarcinogenic Agents; Azoxymethane; Carcinogens; Chemoprevention; Colitis; Colonic Neoplasms; Coumaric Acids; Deoxyguanosine; Dextran Sulfate; Dipeptides; Disease Models, Animal; Heme Oxygenase (Decyclizing); Intestinal Mucosa; Male; Mice; Mice, Inbred ICR; Oxidative Stress; Prodrugs | 2008 |
Voluntary exercise inhibits intestinal tumorigenesis in Apc(Min/+) mice and azoxymethane/dextran sulfate sodium-treated mice.
Topics: Animals; Azoxymethane; beta Catenin; Biomarkers, Tumor; Cadherins; Carcinogens; Codon, Nonsense; Dextran Sulfate; Dietary Fats; Dinoprostone; Disease Models, Animal; Female; Genes, APC; Insulin-Like Growth Factor Binding Protein 1; Insulin-Like Growth Factor Binding Protein 3; Intestinal Neoplasms; Intestine, Small; Male; Mice; Mice, Mutant Strains; Physical Conditioning, Animal | 2008 |
Farnesoid X receptor deficiency in mice leads to increased intestinal epithelial cell proliferation and tumor development.
Topics: Animals; Azoxymethane; Carcinogenicity Tests; Cell Proliferation; Colon; Disease Models, Animal; DNA-Binding Proteins; Intestinal Neoplasms; Intestines; Liver X Receptors; Mice; Mice, Inbred C57BL; Mice, Transgenic; Orphan Nuclear Receptors; Receptors, Cytoplasmic and Nuclear; Transcription Factors | 2009 |
Adiponectin deficiency enhances colorectal carcinogenesis and liver tumor formation induced by azoxymethane in mice.
Topics: Adiponectin; Animals; Azoxymethane; Cell Proliferation; Colorectal Neoplasms; Cyclooxygenase 2; Disease Models, Animal; Liver Neoplasms, Experimental; Mice; Mice, Inbred C57BL; Mice, Knockout; Proliferating Cell Nuclear Antigen; Time Factors; Up-Regulation | 2008 |
An n-3 PUFA-rich microalgal oil diet protects to a similar extent as a fish oil-rich diet against AOM-induced colonic aberrant crypt foci in F344 rats.
Topics: Animal Feed; Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Corn Oil; Dietary Fats; Disease Models, Animal; Eukaryota; Fatty Acids, Omega-3; Fish Oils; Intestinal Mucosa; Male; Oxidative Stress; Plant Oils; Precancerous Conditions; Rats; Rats, Inbred F344 | 2009 |
3,3'-diindolylmethane attenuates colonic inflammation and tumorigenesis in mice.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Body Weight; Carcinogens; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Dextran Sulfate; Dinoprostone; Disease Models, Animal; Indoles; Mice; Mice, Inbred BALB C; NF-kappa B; Nitric Oxide; Peroxidase; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Weight Loss | 2009 |
Epigenetic modulation of the retinoid X receptor alpha by green tea in the azoxymethane-Apc Min/+ mouse model of intestinal cancer.
Topics: Adenoma; Animals; Azoxymethane; beta Catenin; Camellia sinensis; Carcinogens; Cyclin D1; Disease Models, Animal; DNA Methylation; Down-Regulation; Epigenesis, Genetic; Female; Genes, APC; Immunoenzyme Techniques; Intestinal Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Promoter Regions, Genetic; Retinoid X Receptor alpha; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tea | 2009 |
Mucin-depleted foci show strong activation of inflammatory markers in 1,2-dimethylhydrazine-induced carcinogenesis and are promoted by the inflammatory agent sodium dextran sulfate.
Topics: 1,2-Dimethylhydrazine; Animals; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Down-Regulation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Immunohistochemistry; Inflammation; Male; Mucin-2; Nitric Oxide Synthase Type II; Precancerous Conditions; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; Up-Regulation | 2009 |
Targeted genetic disruption of peroxisome proliferator-activated receptor-delta and colonic tumorigenesis.
Topics: Animals; Azoxymethane; Cell Line, Tumor; Colonic Neoplasms; Disease Models, Animal; Exons; Gene Deletion; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Transgenic; Models, Genetic; PPAR delta; Reverse Transcriptase Polymerase Chain Reaction; Vascular Endothelial Growth Factor A | 2009 |
Long-term ingestion of reduced glutathione suppressed an accelerating effect of beef tallow diet on colon carcinogenesis in rats.
Topics: Animals; Antioxidants; Arachidonic Acid; Azoxymethane; beta Catenin; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Cyclooxygenase 2; Disease Models, Animal; Fats; Glutathione; Glutathione Reductase; Intestinal Mucosa; Male; Oxidative Stress; Precancerous Conditions; Random Allocation; Rats; Rats, Sprague-Dawley | 2009 |
Involvement of JNK pathway in the promotion of the early stage of colorectal carcinogenesis under high-fat dietary conditions.
Topics: Animals; Azoxymethane; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; Colon; Colorectal Neoplasms; Dietary Fats; Disease Models, Animal; Humans; Insulin; Insulin Resistance; Intestinal Mucosa; MAP Kinase Kinase 4; Mice; Mice, Inbred C57BL; Signal Transduction | 2009 |
Epithelial vanin-1 controls inflammation-driven carcinogenesis in the colitis-associated colon cancer model.
Topics: Amidohydrolases; Animals; Azoxymethane; Blotting, Western; Carcinogens; Cell Adhesion Molecules; Colitis; Colonic Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; Epithelial Cells; Female; Fluorescent Antibody Technique; GPI-Linked Proteins; Inflammation; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; NF-kappa B; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2010 |
Lack of efficacy of blueberry in nutritional prevention of azoxymethane-initiated cancers of rat small intestine and colon.
Topics: Adenocarcinoma; Adenomatous Polyps; Animals; Azoxymethane; Blueberry Plants; C-Peptide; Colonic Neoplasms; Disease Models, Animal; Disease Progression; Duodenal Neoplasms; Female; Incidence; Male; Nutrition Therapy; Rats; Rats, Sprague-Dawley | 2009 |
Pla2g2a attenuates colon tumorigenesis in azoxymethane-treated C57BL/6 mice; expression studies reveal Pla2g2a target genes and pathways.
Topics: Animals; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colonic Neoplasms; Disease Models, Animal; Female; Gene Expression Regulation, Neoplastic; Group II Phospholipases A2; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic | 2009 |
Aberrant DNA methylation occurs in colon neoplasms arising in the azoxymethane colon cancer model.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis Regulatory Proteins; Azoxymethane; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion Molecule-1; Cell Adhesion Molecules; Colonic Neoplasms; Connexins; Cyclin-Dependent Kinase Inhibitor p16; Death-Associated Protein Kinases; Disease Models, Animal; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; DNA-Binding Proteins; Gap Junction delta-2 Protein; Humans; Immunoglobulins; Inhibitor of Differentiation Proteins; Insulin-Like Growth Factor Binding Protein 3; Intestinal Mucosa; Membrane Proteins; Mice; MutL Protein Homolog 1; Nuclear Proteins; Receptors, CXCR4; Repressor Proteins; Transcription Factors; Tumor Suppressor Proteins | 2010 |
Apoptosis signal-regulating kinase 1 regulates colitis and colitis-associated tumorigenesis by the innate immune responses.
Topics: Animals; Apoptosis; Azoxymethane; Bone Marrow Transplantation; Cell Proliferation; Cells, Cultured; Citrobacter rodentium; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Disease Susceptibility; Female; Gene Expression Regulation; Humans; Immunity, Innate; Macrophages; Male; MAP Kinase Kinase Kinase 5; Mice; Mice, Inbred C57BL; Mice, Knockout; p38 Mitogen-Activated Protein Kinases; Phagocytosis; RNA Interference; Severity of Illness Index; Time Factors | 2010 |
Increased visceral fat mass and insulin signaling in colitis-related colon carcinogenesis model mice.
Topics: Animals; Azoxymethane; Carcinogens; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Insulin; Insulin-Like Growth Factor I; Intra-Abdominal Fat; Leptin; Male; Mice; Mice, Inbred ICR; Signal Transduction | 2010 |
Phosphatidylinositol 3-kinase gamma inhibition ameliorates inflammation and tumor growth in a model of colitis-associated cancer.
Topics: Animals; Azoxymethane; CD4-Positive T-Lymphocytes; Colitis; Colon; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Immunity, Innate; Inflammatory Bowel Diseases; Mice; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors | 2010 |
CD95 is cytoprotective for intestinal epithelial cells in colitis.
Topics: Animals; Azoxymethane; Bone Marrow Transplantation; Carcinogens; Cell Transformation, Neoplastic; Colitis, Ulcerative; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Fas Ligand Protein; fas Receptor; Intestinal Mucosa; Mice; Mice, Knockout | 2010 |
Expression profiles of proliferative and antiapoptotic genes in sporadic and colitis-related mouse colon cancer models.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Azoxymethane; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Cell Cycle Proteins; Cell Proliferation; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Cyclooxygenase 2; Dextran Sulfate; Disease Models, Animal; Disease Progression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Inhibitor of Apoptosis Proteins; Male; Mice; Mice, Inbred ICR; Microdissection; Microtubule-Associated Proteins; Nitric Oxide Synthase Type II; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-myb; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; Survivin; Telomerase; Transcription Factor 4 | 2010 |
Deer velvet supplementation decreases the grade and metastasis of azoxymethane-induced colon cancer in the male rat.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Azoxymethane; Colonic Neoplasms; Disease Models, Animal; Male; Neoplasm Metastasis; Rats; Rats, Wistar; Skin; Tissue Extracts | 2010 |
CCL2 (pM levels) as a therapeutic agent in Inflammatory Bowel Disease models in mice.
Topics: Animals; Azoxymethane; Blotting, Western; Carcinogens; Cell Adhesion; Cell Movement; Cell Proliferation; Chemokine CCL2; Colitis; Colon; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Immunoenzyme Techniques; Inflammatory Bowel Diseases; Macrophages; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Monocytes; Trinitrobenzenesulfonic Acid | 2010 |
R-flurbiprofen suppresses distal nonmucin-producing colorectal tumors in azoxymethane-treated rats, without suppressing eicosanoid production.
Topics: Animals; Antineoplastic Agents; Azoxymethane; Carcinogens; Colorectal Neoplasms; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Eicosanoids; Flurbiprofen; Male; Mucins; Rats; Rats, Sprague-Dawley; Sulindac | 2010 |
Identification of gene expression profiles correlated to tumor progression in a preclinical model of colon carcinogenesis.
Topics: Animals; Azoxymethane; Biomarkers, Tumor; Carcinogens; Cell Transformation, Neoplastic; Colonic Neoplasms; Disease Models, Animal; Disease Progression; Gene Expression Profiling; Male; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2010 |
N-acetylcysteine attenuates cerebral complications of non-acetaminophen-induced acute liver failure in mice: antioxidant and anti-inflammatory mechanisms.
Topics: Acetaminophen; Acetylcysteine; Animals; Antioxidants; Azoxymethane; Brain Edema; Carcinogens; Cytokines; Disease Models, Animal; Hepatic Encephalopathy; Inflammation; Inflammation Mediators; Liver Failure, Acute; Male; Mice; Mice, Inbred C57BL; Oxidative Stress | 2010 |
2,3',4,4',5'-Pentamethoxy-trans-stilbene, a resveratrol derivative, inhibits colitis-associated colorectal carcinogenesis in mice.
Topics: Adenocarcinoma; Animals; Apoptosis; Azoxymethane; Cell Line, Tumor; Cell Proliferation; Colitis; Colonic Neoplasms; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred BALB C; Stilbenes | 2010 |
The role of prostaglandin E2 (PGE 2) in toll-like receptor 4 (TLR4)-mediated colitis-associated neoplasia.
Topics: Amphiregulin; Animals; Azoxymethane; Cell Proliferation; Colitis; Colonic Neoplasms; Cyclooxygenase 2; Dextran Sulfate; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; EGF Family of Proteins; ErbB Receptors; Female; Glycoproteins; Intercellular Signaling Peptides and Proteins; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Prostaglandins; Signal Transduction; Toll-Like Receptor 4 | 2010 |
Pterostilbene inhibits colorectal aberrant crypt foci (ACF) and colon carcinogenesis via suppression of multiple signal transduction pathways in azoxymethane-treated mice.
Topics: Animals; Azoxymethane; Colon; Colonic Neoplasms; Disease Models, Animal; Down-Regulation; Humans; Male; Mice; Mice, Inbred ICR; Signal Transduction; Stilbenes | 2010 |
High susceptibility to azoxymethane-induced colorectal carcinogenesis in obese KK-Ay mice.
Topics: Aberrant Crypt Foci; Adenocarcinoma; Animals; Azoxymethane; Carcinogens; Colorectal Neoplasms; Disease Models, Animal; Disease Susceptibility; Incidence; Mice; Mice, Inbred C57BL; Mice, Obese; Receptors, Leptin | 2011 |
In vivo, dual-modality OCT/LIF imaging using a novel VEGF receptor-targeted NIR fluorescent probe in the AOM-treated mouse model.
Topics: Animals; Azoxymethane; Colon; Disease Models, Animal; Fluorescent Dyes; Imaging, Three-Dimensional; Lasers; Mice; Microscopy, Fluorescence; Receptors, Vascular Endothelial Growth Factor; Spectroscopy, Near-Infrared; Tomography, Optical Coherence | 2011 |
Mthfd1 is a modifier of chemically induced intestinal carcinogenesis.
Topics: Aminohydrolases; Animals; Apoptosis; Azoxymethane; Biomarkers, Tumor; Blotting, Western; Carcinogens; Cell Proliferation; Colonic Neoplasms; Disease Models, Animal; DNA, Neoplasm; Female; Formate-Tetrahydrofolate Ligase; Gene Expression Profiling; Immunoenzyme Techniques; Male; Methenyltetrahydrofolate Cyclohydrolase; Methylenetetrahydrofolate Dehydrogenase (NADP); Mice; Mice, Inbred C57BL; Mice, Knockout; Multienzyme Complexes; Multifunctional Enzymes; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Uracil | 2011 |
MTGR1 is required for tumorigenesis in the murine AOM/DSS colitis-associated carcinoma model.
Topics: Animals; Azoxymethane; Carcinoma; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Disease Progression; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Repressor Proteins | 2011 |
A two-locus system controls susceptibility to colitis-associated colon cancer in mice.
Topics: Animals; Azoxymethane; Carcinogens; Chromosome Mapping; Chromosomes, Mammalian; Colitis; Colorectal Neoplasms; Crosses, Genetic; Disease Models, Animal; Female; Genetic Linkage; Genetic Loci; Genetic Predisposition to Disease; Male; Mice; Mice, Inbred A; Mice, Inbred C57BL; Quantitative Trait Loci | 2010 |
Loss of adiponectin promotes intestinal carcinogenesis in Min and wild-type mice.
Topics: Adenomatous Polyposis Coli; Adiponectin; AMP-Activated Protein Kinases; Animals; Azoxymethane; Cells, Cultured; Chi-Square Distribution; Colon; Colonic Polyps; Disease Models, Animal; Down-Regulation; Enzyme Activation; Female; Gene Expression Regulation, Neoplastic; Genes, APC; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphorylation; Plasminogen Activator Inhibitor 1; Signal Transduction; Time Factors; Tumor Burden; Up-Regulation | 2011 |
Pterostilbene is more potent than resveratrol in preventing azoxymethane (AOM)-induced colon tumorigenesis via activation of the NF-E2-related factor 2 (Nrf2)-mediated antioxidant signaling pathway.
Topics: Animals; Antioxidants; Azoxymethane; Colonic Neoplasms; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Mice, Inbred BALB C; NF-E2-Related Factor 2; Resveratrol; Signal Transduction; Stilbenes | 2011 |
Chemoprevention of azoxymethane/dextran sodium sulfate-induced mouse colon carcinogenesis by freeze-dried yam sanyaku and its constituent diosgenin.
Topics: Animals; Azoxymethane; Biomarkers, Tumor; Carcinogens; Colonic Neoplasms; Dextran Sulfate; Dioscorea; Diosgenin; Disease Models, Animal; Gene Expression Profiling; Male; Mice; Mice, Inbred ICR; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2011 |
The Wnt antagonist Dkk1 regulates intestinal epithelial homeostasis and wound repair.
Topics: Acute Disease; Animals; Antibodies, Monoclonal; Azoxymethane; beta Catenin; Cell Proliferation; Cells, Cultured; Colitis; Colon; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Down-Regulation; Homeostasis; Injections, Intraperitoneal; Intercellular Signaling Peptides and Proteins; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Mice, Transgenic; Signal Transduction; Time Factors; Wnt Proteins; Wound Healing | 2011 |
Application of near-infrared fluorescence imaging using a polymeric nanoparticle-based probe for the diagnosis and therapeutic monitoring of colon cancer.
Topics: Adenocarcinoma; Animals; Azoxymethane; Cell Line, Tumor; Colon; Colonic Neoplasms; Diagnostic Imaging; Disease Models, Animal; Disease Progression; Drug Therapy; Enzyme Inhibitors; Fluorescent Dyes; Humans; Male; Matrix Metalloproteinase 7; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred Strains; Nanoparticles; Treatment Outcome; Xenograft Model Antitumor Assays | 2011 |
Green tea, phytic acid, and inositol in combination reduced the incidence of azoxymethane-induced colon tumors in Fisher 344 male rats.
Topics: Administration, Oral; Animals; Anticarcinogenic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione Transferase; Inositol; Male; Phytic Acid; Phytotherapy; Plant Extracts; Rats; Rats, Inbred F344; Tea | 2011 |
Effects of diet-induced obesity on colitis-associated colon tumor formation in A/J mice.
Topics: Animals; Azoxymethane; Blotting, Western; Carcinogens; Colitis; Colon; Colonic Neoplasms; Diet, High-Fat; Disease Models, Animal; Male; Mice; Obesity; Signal Transduction | 2012 |
The neurotensin receptor-1 promotes tumor development in a sporadic but not an inflammation-associated mouse model of colon cancer.
Topics: Animals; Azoxymethane; Chemokine CXCL2; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Female; Gene Expression; Humans; Immunohistochemistry; Interleukin-6; Kaplan-Meier Estimate; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Pyrazoles; Quinolines; Receptors, Neurotensin; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tumor Necrosis Factor-alpha | 2012 |
Notch1 regulates the effects of matrix metalloproteinase-9 on colitis-associated cancer in mice.
Topics: Amyloid Precursor Protein Secretases; Animals; Apoptosis; Azoxymethane; Caspase 3; Colitis; Colon; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cytokines; Dextran Sulfate; Dipeptides; Disease Models, Animal; DNA Damage; Enzyme Inhibitors; Fibroblasts; Gamma Rays; HCT116 Cells; Humans; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptor, Notch1; RNA, Messenger; Signal Transduction; Time Factors; Transfection; Tumor Suppressor Protein p53 | 2011 |
Prevention of colitis-associated colorectal cancer with 8-hydroxydeoxyguanosine.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Anticarcinogenic Agents; Azoxymethane; Colitis; Colorectal Neoplasms; Deoxyguanosine; Dextrans; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Inflammation; Interleukin-10; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neoplasms; STAT3 Transcription Factor; Sulfates | 2011 |
Disruption of the mouse protein tyrosine kinase 6 gene prevents STAT3 activation and confers resistance to azoxymethane.
Topics: Aberrant Crypt Foci; Animals; Apoptosis; Azoxymethane; Carcinogens; Cell Proliferation; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; HCT116 Cells; Humans; Immunoblotting; Immunohistochemistry; Mice; Mice, Knockout; Neoplasm Proteins; Phosphorylation; Protein-Tyrosine Kinases; RNA Interference; Signal Transduction; src-Family Kinases; STAT3 Transcription Factor; Time Factors | 2011 |
A Src family kinase inhibitor improves survival in experimental acute liver failure associated with elevated cerebral and circulating vascular endothelial growth factor levels.
Topics: Ammonium Chloride; Aniline Compounds; Animals; Apoptosis; Astrocytes; Azoxymethane; Brain; Brain Edema; Cells, Cultured; Disease Models, Animal; Endothelial Growth Factors; Green Fluorescent Proteins; Hepatic Encephalopathy; Immunohistochemistry; In Situ Nick-End Labeling; Interferon-gamma; Lipopolysaccharides; Liver; Liver Failure, Acute; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Nitriles; Peptides, Cyclic; Protein Kinase Inhibitors; Quinolines; Recombinant Fusion Proteins; src-Family Kinases; Time Factors; Vascular Endothelial Growth Factor A | 2011 |
Non-digestible fraction of cooked bean (Phaseolus vulgaris L.) cultivar Bayo Madero suppresses colonic aberrant crypt foci in azoxymethane-induced rats.
Topics: Animal Feed; Animals; Azoxymethane; Colon; Colonic Neoplasms; Cooking; Cytoprotection; Dietary Carbohydrates; Dietary Fiber; Digestion; Disease Models, Animal; Eating; Fatty Acids, Volatile; Feces; Intestinal Mucosa; Male; Phaseolus; Plant Proteins, Dietary; Rats; Rats, Sprague-Dawley; Solubility | 2010 |
Chemoprevention of colon cancer in a rat carcinogenesis model using a novel nanotechnology-based combined treatment system.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Combined Chemotherapy Protocols; Aspirin; Azoxymethane; Cell Proliferation; Colonic Neoplasms; Disease Models, Animal; Drug Delivery Systems; Folic Acid; Lactic Acid; Male; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Vitamin B Complex | 2011 |
Early lesion formation in colorectal carcinogenesis is associated with adiponectin status whereas neoplastic lesions are associated with diet and sex in C57BL/6J mice.
Topics: Adiponectin; Animals; Azoxymethane; Cell Transformation, Neoplastic; Colon; Colorectal Neoplasms; Dextran Sulfate; Diet; Disease Models, Animal; Female; Gene Expression Regulation; Genotype; Insulin; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptor, Insulin; Receptors, Adiponectin; Risk Factors; Sex Factors; Signal Transduction; Toll-Like Receptor 4 | 2011 |
Monosodium glutamate-induced diabetic mice are susceptible to azoxymethane-induced colon tumorigenesis.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Diabetes Mellitus, Experimental; Disease Models, Animal; Disease Susceptibility; Hypercholesterolemia; Hyperglycemia; Hyperinsulinism; Insulin-Like Growth Factor I; Male; Mice; Mice, Inbred ICR; Precancerous Conditions; Receptor, IGF Type 1; RNA, Messenger; Sodium Glutamate | 2012 |
Optical imaging of MMP expression and cancer progression in an inflammation-induced colon cancer model.
Topics: Animals; Azoxymethane; beta Catenin; Blotting, Western; Carbocyanines; Carcinogens; Colonic Neoplasms; Dextran Sulfate; Diagnostic Imaging; Disease Models, Animal; Disease Progression; Immunoenzyme Techniques; Inflammation; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Peptide Fragments | 2012 |
Study of 5-hydroxymethylfurfural and its metabolite 5-sulfooxymethylfurfural on induction of colonic aberrant crypt foci in wild-type mice and transgenic mice expressing human sulfotransferases 1A1 and 1A2.
Topics: Aberrant Crypt Foci; Animals; Arylsulfotransferase; Azoxymethane; Colon; Disease Models, Animal; Female; Furaldehyde; Gene Expression Regulation; Intestinal Mucosa; Kidney; Liver; Male; Mice; Mice, Inbred Strains; Mice, Transgenic | 2012 |
Effect of dietary fibre of barley variety 'Rihane' on azoxymethane-induced aberrant crypt foci development and on colonic microbiota diversity in rats.
Topics: Aberrant Crypt Foci; Animals; Azoxymethane; Bifidobacterium; Carcinogens; Colon; Colorectal Neoplasms; Dietary Fiber; Disease Models, Animal; Enterobacteriaceae; Gastrointestinal Contents; Hordeum; Hydrogen-Ion Concentration; Intestinal Mucosa; Male; Phylogeny; Prebiotics; Random Allocation; Rats; Rats, Wistar; Seeds; Tunisia | 2012 |
Effects of gut-targeted 15-LOX-1 transgene expression on colonic tumorigenesis in mice.
Topics: Animals; Arachidonate 15-Lipoxygenase; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Disease Models, Animal; Epithelial Cells; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Immunoblotting; Intestinal Mucosa; Mice; Mice, Transgenic; NF-kappa B; Nitric Oxide Synthase Type II; Real-Time Polymerase Chain Reaction; RNA, Messenger; Transgenes; Tumor Necrosis Factor-alpha; Up-Regulation | 2012 |
P53 gene mutation increases progastrin dependent colonic proliferation and colon cancer formation in mice.
Topics: Aberrant Crypt Foci; Animals; Azoxymethane; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; Colonic Neoplasms; Disease Models, Animal; Female; Gastrins; Humans; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Protein Precursors; Tumor Suppressor Protein p53 | 2012 |
Arsenic and chromium in drinking water promote tumorigenesis in a mouse colitis-associated colorectal cancer model and the potential mechanism is ROS-mediated Wnt/β-catenin signaling pathway.
Topics: Animals; Antioxidants; Arsenic; Azoxymethane; Carcinogens, Environmental; Cell Line; Chromium; Colitis; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Drinking Water; Electrophoresis, Gel, Two-Dimensional; Humans; Mass Spectrometry; Mice; Mice, Inbred C57BL; Reactive Oxygen Species; Water Pollutants, Chemical; Wnt Signaling Pathway | 2012 |
RETRACTED: Obesity-induced increase in tumor necrosis factor-α leads to development of colon cancer in mice.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Apoptosis; Azoxymethane; Blotting, Western; Cell Proliferation; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Enzyme Activation; HT29 Cells; Humans; Hyperinsulinism; Hypoglycemic Agents; I-kappa B Kinase; Immunohistochemistry; Inflammation Mediators; Infliximab; Insulin; JNK Mitogen-Activated Protein Kinases; Male; Mice; Mice, Inbred C57BL; Mice, SCID; Obesity; Phosphatidylinositol 3-Kinase; Pioglitazone; Proto-Oncogene Proteins c-akt; Signal Transduction; Thiazolidinediones; Time Factors; TOR Serine-Threonine Kinases; Tumor Burden; Tumor Necrosis Factor-alpha; Up-Regulation; Xenograft Model Antitumor Assays | 2012 |
Genistein, a soya isoflavone, prevents azoxymethane-induced up-regulation of WNT/β-catenin signalling and reduces colon pre-neoplasia in rats.
Topics: Aberrant Crypt Foci; Animals; Azoxymethane; Biomarkers; Carcinogens; Colon, Descending; Colonic Neoplasms; Cyclin D1; Disease Models, Animal; Down-Regulation; Female; Genistein; Lactation; Male; Maternal Nutritional Physiological Phenomena; Precancerous Conditions; Pregnancy; Proto-Oncogene Proteins c-myc; Rats; Rats, Sprague-Dawley; Soybean Proteins; Wnt Signaling Pathway | 2013 |
Deleterious effects of high concentrations of (-)-epigallocatechin-3-gallate and atorvastatin in mice with colon inflammation.
Topics: Animals; Atorvastatin; Azoxymethane; Catechin; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Gastrointestinal Hemorrhage; Heptanoic Acids; Leukotriene B4; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Pyrroles; Rectum; Weight Loss | 2012 |
Efficacy of EGFR inhibition is modulated by model, sex, genetic background and diet: implications for preclinical cancer prevention and therapy trials.
Topics: Animals; Antineoplastic Agents; Azoxymethane; Colorectal Neoplasms; Diet; Disease Models, Animal; ErbB Receptors; Female; Male; Mice; Mice, Inbred C57BL; Phosphorylation; Quinazolines; Sex Factors; Tyrphostins | 2012 |
Modeling colitis-associated cancer with azoxymethane (AOM) and dextran sulfate sodium (DSS).
Topics: Animals; Azoxymethane; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Female; Male; Mice | 2012 |
Suppressive effect of pioglitazone, a PPAR gamma ligand, on azoxymethane-induced colon aberrant crypt foci in KK-Ay mice.
Topics: Aberrant Crypt Foci; Adipokines; Animals; Azoxymethane; Biomarkers; Carcinogens; Colorectal Neoplasms; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Hypoglycemic Agents; Immunoenzyme Techniques; Insulin; Intra-Abdominal Fat; Leptin; Lipids; Mice; Mice, Inbred C57BL; Obesity; Pioglitazone; PPAR gamma; Thiazolidinediones | 2012 |
Studies on the chemopreventive effect of carnitine on tumorigenesis in vivo, using two experimental murine models of colon cancer.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Carnitine; Carnitine O-Acetyltransferase; Cell Transformation, Neoplastic; Colonic Neoplasms; Diet; Disease Models, Animal; Genes, APC; Intestines; Male; Mice; Mice, Inbred C57BL; Mutation | 2012 |
A polyacetylene-rich extract from Gymnaster koraiensis strongly inhibits colitis-associated colon cancer in mice.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Asteraceae; Azoxymethane; Cell Proliferation; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Inflammation; Liver; Male; Mice; Mice, Inbred C57BL; Plant Extracts; Polyynes | 2013 |
Inhibitory effects of mofezolac, a cyclooxygenase-1 selective inhibitor, on intestinal carcinogenesis.
Topics: Animals; Antineoplastic Agents; Azoxymethane; Carcinogenicity Tests; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Female; Genes, APC; Intestinal Neoplasms; Isoenzymes; Isoxazoles; Male; Membrane Proteins; Mice; Mice, Knockout; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred F344; Sulfonamides | 2002 |
Dietary inulin suppresses azoxymethane-induced preneoplastic aberrant crypt foci in mature Fisher 344 rats.
Topics: Age Factors; Animals; Azoxymethane; Carcinogens; Cecum; Colon; Colonic Neoplasms; Dietary Fiber; Disease Models, Animal; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; Inulin; Male; Organ Size; Precancerous Conditions; Rats; Rats, Inbred F344 | 2002 |
Dietary inulin suppresses azoxymethane-induced aberrant crypt foci and colon tumors at the promotion stage in young Fisher 344 rats.
Topics: Age Factors; Animals; Azoxymethane; Carcinogens; Cecum; Colon; Colonic Neoplasms; Diarrhea; Dietary Fiber; Disease Models, Animal; Hydrogen-Ion Concentration; Intestinal Neoplasms; Intestine, Small; Inulin; Male; Organ Size; Precancerous Conditions; Rats; Rats, Inbred F344; Time Factors | 2002 |
Ursodeoxycholic acid inhibits the initiation and postinitiation phases of azoxymethane-induced colonic tumor development.
Topics: Animals; Azoxymethane; Cholagogues and Choleretics; Colonic Neoplasms; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Incidence; Male; Rats; Rats, Inbred F344; Time Factors; Treatment Outcome; Ursodeoxycholic Acid | 2002 |
Ursodeoxycholic acid and F(6)-D(3) inhibit aberrant crypt proliferation in the rat azoxymethane model of colon cancer: roles of cyclin D1 and E-cadherin.
Topics: Animals; Azoxymethane; Base Sequence; Biomarkers, Tumor; Biopsy, Needle; Blotting, Western; Cadherins; Cell Division; Cholecalciferol; Colonic Neoplasms; Cyclin D1; Disease Models, Animal; Immunohistochemistry; Injections, Intraperitoneal; Intestinal Mucosa; Male; Molecular Sequence Data; Neoplasms, Experimental; Polymerase Chain Reaction; Random Allocation; Rats; Rats, Inbred F344; Reference Values; RNA, Messenger; Sensitivity and Specificity; Ursodeoxycholic Acid | 2002 |
Food-borne radiolytic compounds (2-alkylcyclobutanones)may promote experimental colon carcinogenesis.
Topics: Analysis of Variance; Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Cyclobutanes; Disease Models, Animal; Food Irradiation; Male; Neoplasms, Experimental; Rats; Rats, Wistar | 2002 |
Tomato and garlic can modulate azoxymethane-induced colon carcinogenesis in rats.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Carcinogenicity Tests; Carcinogens; Cell Division; Colon; Colonic Neoplasms; Disease Models, Animal; Garlic; Glutathione Transferase; Injections, Subcutaneous; Lipid Peroxidation; Onions; Phytotherapy; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Solanum lycopersicum | 2003 |
Characterization of the role of protein kinase C isozymes in colon carcinogenesis using transgenic mouse models.
Topics: Animals; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Disease Models, Animal; Humans; Immunohistochemistry; Isoenzymes; Mice; Mice, Transgenic; Mucous Membrane; Protein Kinase C | 2003 |
Suppression by nimesulide of bombesin-enhanced peritoneal metastasis of intestinal adenocarcinomas induced by azoxymethane in Wistar rats.
Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoxymethane; Bombesin; Carcinogens; Disease Models, Animal; Intestinal Neoplasms; Lymphatic Metastasis; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Peritoneal Neoplasms; Rats; Rats, Wistar; Sulfonamides | 2003 |
A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate.
Topics: Adenocarcinoma; Adenoma; Animals; Anticoagulants; Azoxymethane; beta Catenin; Carcinogens; Colitis; Colonic Neoplasms; Cyclooxygenase 2; Cytoskeletal Proteins; Dextran Sulfate; Disease Models, Animal; Inflammation; Injections, Intraperitoneal; Isoenzymes; Male; Mast Cells; Mice; Mice, Inbred ICR; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin-Endoperoxide Synthases; Trans-Activators; Tumor Suppressor Protein p53 | 2003 |
Peroxisome proliferator-activated receptor-delta attenuates colon carcinogenesis.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Colonic Polyps; Disease Models, Animal; Mice; Mice, Knockout; Mice, Mutant Strains; Phenotype; Receptors, Cytoplasmic and Nuclear; Transcription Factors | 2004 |
Transforming growth factor beta receptor type II inactivation promotes the establishment and progression of colon cancer.
Topics: Animals; Apoptosis; Azoxymethane; Carcinogens; Carrier Proteins; Cell Differentiation; Cell Division; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Cyclooxygenase 2; Disease Models, Animal; Disease Progression; Fatty Acid-Binding Proteins; Female; Gene Silencing; Genetic Predisposition to Disease; Isoenzymes; Male; Mice; Mutation; Prostaglandin-Endoperoxide Synthases; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta | 2004 |
Diosgenin, a steroid saponin of Trigonella foenum graecum (Fenugreek), inhibits azoxymethane-induced aberrant crypt foci formation in F344 rats and induces apoptosis in HT-29 human colon cancer cells.
Topics: Animals; Apoptosis; Azoxymethane; Cell Division; Colonic Neoplasms; Diosgenin; Disease Models, Animal; History, Early Modern 1451-1600; HT29 Cells; Humans; Intestinal Mucosa; Male; Plant Extracts; Precancerous Conditions; Random Allocation; Rats; Rats, Inbred F344; Reference Values; Saponins; Sensitivity and Specificity; Trigonella; Tumor Cells, Cultured | 2004 |
Lactoferrin modifies apoptosis-related gene expression in the colon of the azoxymethane-treated rat.
Topics: Administration, Oral; Animals; Apoptosis; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Chemoprevention; Colonic Neoplasms; Cyclin D1; Disease Models, Animal; Fas Ligand Protein; Gene Expression Regulation; Lactoferrin; Male; Membrane Glycoproteins; Rats; Rats, Inbred F344; Up-Regulation | 2004 |
Dietary iron promotes azoxymethane-induced colon tumors in mice.
Topics: Animals; Apoptosis; Azoxymethane; Carcinogens; Cell Division; Colonic Neoplasms; Disease Models, Animal; DNA Damage; Dose-Response Relationship, Drug; In Situ Nick-End Labeling; Iron, Dietary; Mice; Oxidative Stress; Precancerous Conditions; Random Allocation; Time Factors | 2004 |
Immunohistochemical characterisation of the local immune response in azoxymethane-induced colon tumours in the BDIX inbred rat strain.
Topics: Animals; Azoxymethane; CD8-Positive T-Lymphocytes; Colonic Neoplasms; Disease Models, Animal; Immunohistochemistry; Rats | 2004 |
Intestinal immunity of rats with colon cancer is modulated by oligofructose-enriched inulin combined with Lactobacillus rhamnosus and Bifidobacterium lactis.
Topics: Animals; Azoxymethane; Bifidobacterium; Carcinogens; Cell Division; Colonic Neoplasms; Diet; Disease Models, Animal; Interferons; Interleukin-10; Inulin; Killer Cells, Natural; Lactobacillus; Lymph Nodes; Lymphocyte Subsets; Male; Oligosaccharides; Peyer's Patches; Probiotics; Rats; Rats, Inbred F344; Spleen | 2004 |
The nonsteroidal anti-inflammatory drug, nabumetone, differentially inhibits beta-catenin signaling in the MIN mouse and azoxymethane-treated rat models of colon carcinogenesis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoxymethane; beta Catenin; Blotting, Western; Butanones; Cadherins; Carcinogens; Colonic Neoplasms; Cyclin D1; Cytoskeletal Proteins; Disease Models, Animal; Glycogen Synthase Kinase 3; Immunohistochemistry; Male; Mice; Nabumetone; Rats; Signal Transduction; Trans-Activators | 2005 |
Liver receptor homolog 1 contributes to intestinal tumor formation through effects on cell cycle and inflammation.
Topics: Animals; Azoxymethane; Carcinogens; Cell Cycle; Disease Models, Animal; Female; Heterozygote; Humans; Inflammation; Intestinal Neoplasms; Male; Mice; Mice, Inbred C57BL; Receptors, Cytoplasmic and Nuclear; Tumor Necrosis Factor-alpha | 2005 |
Beta-Catenin mutations in a mouse model of inflammation-related colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sodium sulfate.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Azoxymethane; beta Catenin; Colitis; Colonic Neoplasms; Cyclooxygenase 2; Cytoskeletal Proteins; Dextran Sulfate; Disease Models, Animal; Immunohistochemistry; Inflammation; Male; Mice; Mice, Inbred ICR; Mutation; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin-Endoperoxide Synthases; Trans-Activators | 2005 |
Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin).
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Azoxymethane; Carcinogens; Colonic Neoplasms; Dietary Supplements; Disease Models, Animal; Intestinal Mucosa; Male; Panax; Plant Extracts; Quercetin; Rats; Rats, Inbred F344; Rutin; Silymarin | 2005 |
Increased microvascular blood content is an early event in colon carcinogenesis.
Topics: Adenoma; Animals; Azoxymethane; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Disease Models, Animal; Disease Progression; Hemoglobins; Humans; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Microcirculation; Optics and Photonics; Pilot Projects; Precancerous Conditions; Rats; Rats, Inbred F344; Scattering, Radiation | 2005 |
In vivo imaging of colitis and colon cancer development in mice using high resolution chromoendoscopy.
Topics: Animals; Azoxymethane; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Colonoscopes; Colonoscopy; Dextran Sulfate; Disease Models, Animal; Disease Progression; Intestinal Mucosa; Mice; Mice, Inbred Strains; Severity of Illness Index | 2005 |
Azoxymethane is a genetic background-dependent colorectal tumor initiator and promoter in mice: effects of dose, route, and diet.
Topics: Adenocarcinoma; Animals; Azoxymethane; Carcinogens; Colon; Colorectal Neoplasms; Crosses, Genetic; Diet; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Female; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Pregnancy; Research Design; Species Specificity | 2005 |
Predisposition to colorectal cancer in rats with resolved colitis: role of cyclooxygenase-2-derived prostaglandin d2.
Topics: Animals; Azoxymethane; beta Catenin; Colitis; Colon; Colorectal Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Disease Susceptibility; Intramolecular Oxidoreductases; Lipocalins; Male; Prostaglandin D2; Rats; Rats, Wistar; Receptors, Immunologic; Receptors, Prostaglandin; Trinitrobenzenesulfonic Acid | 2005 |
Risk stratification of colon carcinogenesis through enhanced backscattering spectroscopy analysis of the uninvolved colonic mucosa.
Topics: Animals; Azoxymethane; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Disease Models, Animal; Disease Progression; Equipment Design; Female; Humans; Light; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Middle Aged; Pilot Projects; Predictive Value of Tests; Radiography; Rats; Rats, Inbred F344; Risk Factors; Scattering, Radiation; Sensitivity and Specificity; Spectrum Analysis | 2006 |
Noninvasive monitoring of colonic carcinogenesis: feasibility of [(18)F]FDG-PET in the azoxymethane model.
Topics: Adenocarcinoma; Animals; Azoxymethane; Colonic Neoplasms; Disease Models, Animal; Feasibility Studies; Fluorodeoxyglucose F18; Male; Metabolic Clearance Rate; Organ Specificity; Radionuclide Imaging; Radiopharmaceuticals; Rats; Rats, Inbred F344; Reproducibility of Results; Sensitivity and Specificity; Tissue Distribution | 2006 |
Deletion of the carcinoembryonic antigen-related cell adhesion molecule 1 (Ceacam1) gene contributes to colon tumor progression in a murine model of carcinogenesis.
Topics: Animals; Azoxymethane; Blotting, Western; Carcinoembryonic Antigen; Carcinogens; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Disease Models, Animal; Disease Progression; Gene Targeting; Genotype; Mice; Mice, Inbred C57BL; Mice, Knockout | 2006 |
Inhibition of intestinal carcinogenesis by a new flavone derivative, chafuroside, in oolong tea.
Topics: Animals; Antineoplastic Agents; Azoxymethane; Camellia; Colonic Neoplasms; Diet; Disease Models, Animal; Female; Flavones; Heterocyclic Compounds, 4 or More Rings; Intestinal Mucosa; Intestinal Polyps; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phytotherapy; Rats; Rats, Inbred F344; Tea | 2006 |
Effect of dietary apigenin on colonic ornithine decarboxylase activity, aberrant crypt foci formation, and tumorigenesis in different experimental models.
Topics: Animals; Apigenin; Azoxymethane; Caco-2 Cells; Carcinogens; Colon; Colonic Neoplasms; Diet; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Humans; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Precancerous Conditions; Random Allocation | 2006 |
Carbohydrate digestibility predicts colon carcinogenesis in azoxymethane-treated rats.
Topics: Animals; Azoxymethane; Carcinogens; Cecum; Colonic Neoplasms; Dietary Carbohydrates; Dietary Fats; Dietary Fiber; Digestion; Disease Models, Animal; Fructose; Hydrogen-Ion Concentration; Inulin; Lipid Metabolism; Male; Oligosaccharides; Organ Size; Precancerous Conditions; Random Allocation; Rats; Rats, Inbred F344; Solubility; Triglycerides | 2006 |
Long-term feeding of various fat diets modulates azoxymethane-induced colon carcinogenesis through Wnt/beta-catenin signaling in rats.
Topics: Animals; Apoptosis; Azoxymethane; beta Catenin; Cell Proliferation; Cell Transformation, Neoplastic; Colonic Neoplasms; Corn Oil; Cyclin D; Cyclins; Dietary Fats; Disease Models, Animal; Fats; Fish Oils; Male; Olive Oil; Plant Oils; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Signal Transduction; Time Factors; Wnt Proteins | 2007 |
Epidermal growth factor receptor signaling is required for microadenoma formation in the mouse azoxymethane model of colonic carcinogenesis.
Topics: Adenoma; Animals; Azoxymethane; beta Catenin; Carcinogens; Cell Transformation, Neoplastic; Colonic Neoplasms; Cyclin D1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; ErbB Receptors; Gefitinib; Genes, ras; Male; Mice; Mice, Inbred A; Mutation; Quinazolines; Signal Transduction; Up-Regulation | 2007 |
Modulation of transforming growth factor beta2 (TGF-beta2) by inositol hexaphosphate in colon carcinogenesis in rats.
Topics: Animals; Azoxymethane; Carcinogenicity Tests; Carcinogens; Colon; Colonic Neoplasms; Disease Models, Animal; Image Processing, Computer-Assisted; Male; Phytic Acid; Rats; Transforming Growth Factor beta2 | 2006 |
Chemopreventive effects of lupulone, a hop {beta}-acid, on human colon cancer-derived metastatic SW620 cells and in a rat model of colon carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Disease Models, Animal; Fas Ligand Protein; fas Receptor; Humans; Intestinal Mucosa; Male; Mitochondrial Membranes; Neoplasm Metastasis; Permeability; Plant Preparations; Rats; Rats, Wistar; Receptors, TNF-Related Apoptosis-Inducing Ligand; Terpenes | 2007 |
Ursodeoxycholic acid versus sulfasalazine in colitis-related colon carcinogenesis in mice.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Colitis; Colonic Neoplasms; Cyclooxygenase 2; Disease Models, Animal; Male; Mice; Mice, Inbred ICR; RNA, Messenger; Sulfasalazine; Ursodeoxycholic Acid | 2007 |
Global gene expression analysis of the mouse colonic mucosa treated with azoxymethane and dextran sodium sulfate.
Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Gene Expression; Gene Expression Profiling; Inflammation; Intestinal Mucosa; Male; Mice; Mice, Inbred ICR; Oligonucleotide Array Sequence Analysis | 2007 |
Zapotin, a phytochemical present in a Mexican fruit, prevents colon carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Carcinogens; Cell Division; Cell Line, Tumor; Colon; Colonic Neoplasms; Disease Models, Animal; Dose-Response Relationship, Drug; Flavones; Flow Cytometry; HT29 Cells; Humans; Manilkara; Mice; Mice, Inbred Strains; Precancerous Conditions; Time Factors | 2007 |
Guanylyl cyclase C suppresses intestinal tumorigenesis by restricting proliferation and maintaining genomic integrity.
Topics: Animals; Apoptosis; Azoxymethane; beta Catenin; Cell Cycle Proteins; Cell Proliferation; Cell Transformation, Neoplastic; Colonic Neoplasms; Disease Models, Animal; DNA Damage; Gene Expression Regulation, Neoplastic; Genes, APC; Guanylate Cyclase; Intestinal Neoplasms; Intestine, Small; Ki-67 Antigen; Loss of Heterozygosity; Mice; Mice, Knockout; Mutation; Receptors, Enterotoxin; Receptors, Guanylate Cyclase-Coupled; Receptors, Peptide | 2007 |
An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progression.
Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Disease Progression; Inflammation Mediators; Mice; Mutagens | 2007 |
Increased susceptibility of Sf1(+/-) mice to azoxymethane-induced colon tumorigenesis.
Topics: Animals; Azoxymethane; beta Catenin; Colonic Neoplasms; Disease Models, Animal; DNA Primers; DNA-Binding Proteins; Genes, Lethal; Genetic Predisposition to Disease; Genotype; Homeodomain Proteins; Introns; Mice; Mice, Knockout; Nerve Tissue Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA Splicing Factors; Transcription Factors; Transcriptional Activation | 2007 |
9trans,11trans conjugated linoleic acid inhibits the development of azoxymethane-induced colonic aberrant crypt foci in rats.
Topics: Animals; Apoptosis; Azoxymethane; Biomarkers, Tumor; Cell Division; Colon; Colonic Neoplasms; Cyclin D1; Cyclooxygenase 2; Disease Models, Animal; Dose-Response Relationship, Drug; Immunohistochemistry; Intestinal Mucosa; Linoleic Acids, Conjugated; Lipids; Male; PPAR gamma; Precancerous Conditions; Random Allocation; Rats; Rats, Inbred F344 | 2007 |
Serial endoscopy in azoxymethane treated mice using ultra-high resolution optical coherence tomography.
Topics: Adenoma; Animals; Azoxymethane; Colon; Colorectal Neoplasms; Disease Models, Animal; Disease Progression; Endoscopy, Gastrointestinal; Gastrointestinal Neoplasms; Mice; Tomography, Optical Coherence | 2007 |
Flat colorectal cancers are genetically determined and progress to invasion without going through a polypoid stage.
Topics: Animals; Azoxymethane; beta Catenin; Colorectal Neoplasms; Disease Models, Animal; Disease Progression; DNA Mutational Analysis; Endoscopy; Humans; Mice; Neoplasm Invasiveness; Polyploidy | 2007 |
Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis.
Topics: Animals; Azoxymethane; Carcinoma; Cell Transformation, Neoplastic; Chronic Disease; Colitis, Ulcerative; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Etanercept; Immunoglobulin G; Mice; Mice, Mutant Strains; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Tumor Necrosis Factor Decoy Receptors; Tumor Necrosis Factor-alpha | 2008 |
Lack of interleukin-4 receptor alpha chain-dependent signalling promotes azoxymethane-induced colorectal aberrant crypt focus formation in Balb/c mice.
Topics: Animals; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colorectal Neoplasms; Disease Models, Animal; Female; Interleukin-13; Interleukin-4; Intestinal Mucosa; Mice; Mice, Inbred BALB C; Mice, Knockout; Precancerous Conditions; Receptors, Cell Surface; Signal Transduction; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha | 2008 |
Chemoprevention of colon carcinogenesis by oleanolic acid and its analog in male F344 rats and modulation of COX-2 and apoptosis in human colon HT-29 cancer cells.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Cell Proliferation; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; HT29 Cells; Humans; Macrophages; Male; Mice; Nitric Oxide Synthase Type II; Oleanolic Acid; Precancerous Conditions; Rats; Rats, Inbred F344 | 2008 |
5-aminosalicylic acid inhibits colitis-associated colorectal dysplasias in the mouse model of azoxymethane/dextran sulfate sodium-induced colitis.
Topics: Animals; Azoxymethane; Colitis; Colorectal Neoplasms; Cyclooxygenase 2; Dextran Sulfate; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Humans; Immunohistochemistry; Mesalamine; Mice; Random Allocation | 2008 |
Studies of experimental colon cancer.
Topics: Animals; Azoxymethane; Colectomy; Colonic Neoplasms; Colonic Polyps; Disease Models, Animal; Ileum; Rats; Rectum; Research Design | 1984 |
Contrasting effects of subtotal enteric bypass, enterectomy, and colectomy on azoxymethane-induced intestinal carcinogenesis.
Topics: Adaptation, Physiological; Animals; Azo Compounds; Azoxymethane; Cocarcinogenesis; Disease Models, Animal; Hyperplasia; Intestinal Neoplasms; Intestines; Male; Rats | 1980 |
1H MR visible lipids in colon tissue from normal and carcinogen-treated rats.
Topics: Animals; Azoxymethane; Colon; Colonic Neoplasms; Disease Models, Animal; Intestinal Mucosa; Lipid Metabolism; Magnetic Resonance Spectroscopy; Protons; Rats; Rats, Sprague-Dawley | 1995 |
Varying effect of dietary lipids and azoxymethane on early stages of colon carcinogenesis: enumeration of aberrant crypt foci and proliferative indices.
Topics: Analysis of Variance; Animals; Azoxymethane; Carcinogens; Cell Division; Colon; Colonic Neoplasms; Dietary Fats; Disease Models, Animal; Male; Random Allocation; Rats; Rats, Sprague-Dawley | 1995 |
A new experimental model for colorectal carcinogenesis in the rat.
Topics: Animals; Azoxymethane; Bile; Colorectal Neoplasms; Disease Models, Animal; Injections; Male; Rats; Rats, Sprague-Dawley | 1994 |
The ability of two cooked food mutagens to induce aberrant crypt foci in mice.
Topics: Analysis of Variance; Animals; Azoxymethane; Carcinogens; Colon; Cooking; Deoxyguanosine; Diet; Disease Models, Animal; Female; Food, Fortified; Hot Temperature; Hydrogen-Ion Concentration; Imidazoles; Mice; Mice, Inbred C57BL; Mutagens; Quinoxalines; Reference Values; Weight Gain | 1997 |
Wheat bran diet reduces tumor incidence in a rat model of colon cancer independent of effects on distal luminal butyrate concentrations.
Topics: Animals; Avena; Azoxymethane; Body Weight; Butyrates; Carcinogens; Colon; Colonic Neoplasms; Diet; Dietary Fiber; Disease Models, Animal; Dose-Response Relationship, Drug; Eating; Fatty Acids, Volatile; Feces; Hydrogen-Ion Concentration; Incidence; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Triticum; Weight Gain | 1997 |
Relationship between fecal bile acids and the occurrence of colorectal neoplasia in experimental murine ulcerative colitis.
Topics: Adenocarcinoma; Animals; Azoxymethane; Bile Acids and Salts; Carcinogenicity Tests; Carcinogens; Chromatography, High Pressure Liquid; Colitis, Ulcerative; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Mice; Severity of Illness Index | 1998 |
Cyclooxygenase-independent chemoprevention with an aspirin derivative in a rat model of colonic adenocarcinoma.
Topics: Adenocarcinoma; Animals; Aspirin; Azoxymethane; Colonic Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Isoenzymes; Male; Membrane Proteins; Mice; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 1998 |
Azoxymethane-induced fulminant hepatic failure in C57BL/6J mice: characterization of a new animal model.
Topics: Animals; Azoxymethane; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Hepatic Encephalopathy; Liver; Liver Failure; Male; Mice; Mice, Inbred C57BL | 1999 |
Granulocyte marker protein is increased in stools from rats with azoxymethane-induced colon cancer.
Topics: Animals; Azoxymethane; Biomarkers; Colonic Neoplasms; Diet; Dietary Fats; Dietary Fats, Unsaturated; Disease Models, Animal; Feces; Granulocytes; Intestine, Large; Male; Rats; Rats, Sprague-Dawley; Transferrin | 1999 |
Folate deficiency diminishes the occurrence of aberrant crypt foci in the rat colon but does not alter global DNA methylation status.
Topics: Animals; Azoxymethane; Carcinogens; Chromatography, High Pressure Liquid; Colon; Colonic Neoplasms; Data Interpretation, Statistical; Disease Models, Animal; DNA Methylation; Folic Acid; Folic Acid Deficiency; Homocysteine; Injections, Subcutaneous; Intestinal Mucosa; Liver; Male; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Risk Factors; Time Factors | 2000 |
Endogenous N-nitroso compounds, and their precursors, present in bacon, do not initiate or promote aberrant crypt foci in the colon of rats.
Topics: Animals; Azoxymethane; Carcinogens; Cattle; Chickens; Colonic Neoplasms; Dietary Fats; Disease Models, Animal; Feces; Female; Food Handling; Meat; Nitroso Compounds; Random Allocation; Rats; Rats, Inbred F344; Risk Factors; Swine | 2000 |
Dietary whey protein protects against azoxymethane-induced colon tumors in male rats.
Topics: Animals; Azoxymethane; Carcinogens; Caseins; Colonic Neoplasms; Diet; Disease Models, Animal; Female; Male; Milk Proteins; Pregnancy; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric | 2001 |
Effect of bisacodyl and cascara on growth of aberrant crypt foci and malignant tumors in the rat colon.
Topics: Adenocarcinoma; Adenoma; Animals; Azoxymethane; Bisacodyl; Carcinogens; Colon; Colonic Neoplasms; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Male; Precancerous Conditions; Rats; Rats, Wistar; Rhamnus | 2001 |
Development of a multi-organ rat model for evaluating chemopreventive agents: efficacy of indole-3-carbinol.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aflatoxin B1; Animals; Anticarcinogenic Agents; Azoxymethane; Body Weight; Carcinogens; Colonic Neoplasms; Disease Models, Animal; Female; Indoles; Liver; Liver Neoplasms; Mammary Neoplasms, Experimental; Mutagens; Neoplasms; Rats; Rats, Sprague-Dawley; Time Factors | 2002 |
Comparative study of histopathologic characterization of azoxymethane-induced colon tumors in three inbred rat strains.
Topics: Adenocarcinoma; Adenoma; Animals; Azoxymethane; Biomarkers, Tumor; Carcinogens; Colorectal Neoplasms; Disease Models, Animal; Female; Fluorescent Antibody Technique, Indirect; Immunoenzyme Techniques; Injections, Subcutaneous; Male; Polymorphism, Genetic; Rats; Rats, Inbred F344; Reproducibility of Results; Species Specificity; Time Factors | 2002 |
Effect of ursodeoxycholic acid on azoxymethane-induced aberrant crypt foci formation in rat colon: in vitro potential role of intracellular Ca2+.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Bile Acids and Salts; Calcium; Calcium Signaling; Carcinogens; Colon; Colonic Neoplasms; Diet; Disease Models, Animal; Dose-Response Relationship, Drug; Intracellular Fluid; Male; Rats; Rats, Inbred F344; Tumor Cells, Cultured; Ursodeoxycholic Acid | 2002 |
Hepatic pathology of the colon carcinogen, azoxymethane, in Hanford-Moore miniature pigs.
Topics: Animals; Azoxymethane; Chemical and Drug Induced Liver Injury; Colonic Neoplasms; Disease Models, Animal; Female; Hemorrhage; Liver; Male; Necrosis; Rodentia; Species Specificity; Swine; Swine, Miniature | 1991 |
Experimental model of colon cancer: recurrences after surgery alone or associated with intraperitoneal 5-fluorouracil chemotherapy.
Topics: Adenocarcinoma; Animals; Azoxymethane; Colectomy; Colonic Neoplasms; Combined Modality Therapy; Disease Models, Animal; Fluorouracil; Injections, Intraperitoneal; Liver Neoplasms; Male; Neoplasm Recurrence, Local; Prognosis; Random Allocation; Rats | 1991 |
Inhibition of the promotional phase of azoxymethane-induced colon carcinogenesis in the F344 rat by calcium lactate: effect of simulating two human nutrient density levels.
Topics: Animals; Azo Compounds; Azoxymethane; Calcium; Calcium, Dietary; Colonic Neoplasms; Dietary Fats; Disease Models, Animal; Fatty Acids; Feces; Female; Hydrogen-Ion Concentration; Lactates; Lactic Acid; Phosphorus; Rats; Rats, Inbred F344 | 1990 |
Experimental colorectal cancer: the relationship of diet and faecal bile acid concentration to tumour induction.
Topics: Animals; Azoxymethane; Bile Acids and Salts; Colonic Neoplasms; Diet; Dietary Fats; Dietary Fiber; Disease Models, Animal; Feces; Male; Rats; Rats, Inbred Strains; Rectal Neoplasms | 1986 |
Effect of warfarin on formation and growth of pre-neoplastic lesions in chemically induced colorectal cancer in the rat.
Topics: Adenoma; Animals; Azoxymethane; Colon; Colonic Neoplasms; Disease Models, Animal; Intestinal Mucosa; Male; Microscopy, Electron, Scanning; Precancerous Conditions; Random Allocation; Rats; Rats, Inbred Strains; Rectal Neoplasms; Rectum; Warfarin | 1986 |
Effect of deoxycholic acid on the tumour incidence, distribution, and receptor status of colorectal cancer in the rat model.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Deoxycholic Acid; Disease Models, Animal; Male; Rats; Rats, Inbred Strains; Receptors, Steroid; Rectal Neoplasms | 1985 |