azoxymethane has been researched along with Disease Exacerbation in 65 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (4.62) | 18.2507 |
| 2000's | 21 (32.31) | 29.6817 |
| 2010's | 34 (52.31) | 24.3611 |
| 2020's | 7 (10.77) | 2.80 |
| Authors | Studies |
|---|---|
| Djurhuus, D; Nielsen, B; Olsen, J; Pedersen, AE; Sadowska, Z; Tougaard, P; Yassin, M | 1 |
| Chen, X; Han, W; Li, Y; Shi, L; Wan, J; Wang, H; Xie, B | 1 |
| Chen, N; Cheng, L; Dai, L; Deng, H; Dong, Z; Fang, C; Fu, J; Ji, Y; Li, J; Liu, Y; Shi, G; Su, X; Wang, H; Wang, W; Yang, Y; Yu, Y; Zhang, H; Zhang, S | 1 |
| Deguchi, A; Kato, S; Kawanishi, S; Maebashi, U; Matsumoto, K; Morita, A; Motoyoshi, A; Nakahara, T; Nakamoto, T; Nishimura, K; Sueyoshi, M; Takata, K; Tominaga, M | 1 |
| Akbari, A; Asadollahi, P; Ghanavati, R; Javadi, A; Mohammadi, F; Rohani, M; Talebi, M | 1 |
| Alcalde, A; Arias, MA; Bird, PI; Camerer, E; Castro, M; Comas, L; Del Campo, R; Ferrandez, A; Galvez, EM; Garrido, M; Garzón, M; Gil-Gómez, G; Jaime-Sanchez, P; Lanuza, PM; Layunta, E; Martínez-Lostao, L; Metkar, S; Moreno, V; Muñoz, G; Pardo, J; Pelegrín, P; Peña, R; Ramirez-Labrada, A; Santiago, L; Sanz-Pamplona, R; Tapia, E; Uranga, JA; Uranga-Murillo, I | 1 |
| Hu, Y; Ji, X; Li, Z; Liu, S; Lv, H; Ma, H; Wang, J; Wang, S; Wang, X; Wang, Y; Xu, Y; Zhang, B | 1 |
| Boonsanay, V; Brabletz, T; Greten, FR; Heichler, C; Neufert, C; Neurath, MF; Scheibe, K | 1 |
| Liang, H; Lin, Z; Luo, R; Ye, Y; Zeng, L | 1 |
| García-Sanmartín, J; Martínez, A; Martínez-Herrero, S; Narro-Íñiguez, J; Ochoa-Callejero, L; Rubio-Mediavilla, S | 1 |
| Arning, E; Ashcraft, P; Cook, B; Genta, RM; Han, J; Holm, J; Jackson, D; Souza, RF; Sweetman, L; Theiss, AL; Turner, K; Venuprasad, K; Wang, X | 1 |
| Agle, KA; Chen, X; Drobyski, WR; Huang, YW; Oshima, K; Pan, P; Wang, LS; Yearsley, MM; Yu, J; Zhang, J | 1 |
| Ahn, GO; Gu, H; Im, SH; Jeong, S; Kim, HJ; Kim, J; Kim, YE; Lee, M; Lee, YJ; Sung, YC; Weissman, IL; Yeo, S | 1 |
| Chastre, E; Jordan, P; Kotelevets, L; Lehy, T; Mamadou, G; Walker, F | 1 |
| Dong, YW; Feng, Y; Guo, XY; Jiang, WL; Lu, LG; Song, YN; Xiao, JH | 1 |
| Kim, JS; Kim, N; Lee, DH; Lee, HN; Lee, SM; Na, HY; Nam, RH; Park, JH; Shin, E; Sohn, SH; Son, HJ; Song, CH; Surh, YJ | 1 |
| Booth, CJ; D'Souza, SS; Kartchner, BJ; Lee, EC; Malizia, RA; O'Connor, W; Sharp, SP; Stain, SC; Walrath, T | 1 |
| Alexander, JS; Bernas, M; Daley, SK; Kiela, P; Tanoue, N; Thorn, J; Washington, J; Witte, MH | 1 |
| Fujita, M; Fukai, F; Ishibashi, K; Ito-Fujita, Y; Iyoda, T; Kodama, H; Okada, Y; Osawa, T; Sasada, M; Suzuki, H | 1 |
| Akitake-Kawano, R; Chiba, T; Kanda, K; Kawada, K; Kawada, M; Kimura, Y; Nakanishi, Y; Nakatsuji, M; Sakai, Y; Seno, H; Yoshioka, T | 1 |
| Andriana, BB; Hariyani, R; Ishigaki, M; Sato, H; Taketani, A | 1 |
| Alves, KZ; Borges, HL; de Britto, MA; de Matos, DG; Machado, JC; Soldan, M; Soletti, RC | 1 |
| Arber, N; Avivi, D; Kazanov, D; Kraus, S; Naumov, I; Rosin-Arbesfeld, R; Shapira, S; Zilberberg, A | 1 |
| Barton, JK; Leung, SJ; Rice, PS | 1 |
| Chaiyasut, C; Riengrojpitak, S; Suwannalert, P; Tammasakchai, A | 1 |
| Anton, PA; Birli, E; Chang, L; Choi, J; Hatziapostolou, M; Hommes, DW; Iliopoulos, D; Koukos, G; Koutsioumpa, M; Oikonomopoulos, A; Palumbo, T; Polytarchou, C; Pothoulakis, C; Serebrennikova, OB; Tsichlis, PN; van Deen, WK; van der Meulen-de Jong, AE; Verspaget, HW; Vorvis, C | 1 |
| Bai, YP; Chen, H; Ding, F; Li, YY; Liang, C; Shang, K; Sun, MH; Wang, Z; Xu, Y | 1 |
| Chien, SP; Liu, CT; Liu, MY; Periasamy, S; Wu, WH | 1 |
| Bailey, MT; Clinton, SK; Galley, JD; Olivo-Marston, SE; Thomas-Ahner, JM; Xu, J | 1 |
| Chen, P; Han, J; Jin, LX; Ma, H; Pan, JS; Ren, YD; Wu, J; Xiao, C | 1 |
| Ahn, J; Assefnia, S; Bong, YS; Bueno De Mesquita, PJ; Burt, RW; Byers, SW; Neklason, DW; Tuohy, T | 1 |
| Brembeck, FH; Talla, SB | 1 |
| Ahmad, J; El-Shemi, AG; Idris, S; Kensara, OA; Mohamed, AM; Refaat, B | 1 |
| Fields, AP; Fujiwara, K; Kurakata, S; Murray, NR; Necela, BM; Su, W; Thompson, EA | 1 |
| Braun, U; Fields, AP; Leitges, M; Murray, NR; Weems, J | 1 |
| Chun, J; Ghaleb, AM; Iyer, S; Lin, S; Shim, H; Wang, D; Yang, VW; Yun, CC | 1 |
| Frank, JA; Hennings, LJ; Prior, RL; Simmen, FA; Wu, X; Xiao, R | 1 |
| Ergang, P; Kment, M; Mandys, V; Pácha, J; Svec, J | 1 |
| Barney, KA; Blevins, EA; Finkelman, FD; Flick, MJ; Harmel-Laws, E; Horowitz, NA; Kombrinck, KW; Palumbo, JS; Pinkerton, MD; Shaw, MA; Steinbrecher, KA; Talmage, KE; Witte, DP | 1 |
| Bouhadjar, M; Bousserouel, S; Gossé, F; Kauntz, H; Marescaux, J; Raul, F; Soler, L | 1 |
| Barrett, CW; Chaturvedi, R; Fingleton, B; Fischer, MA; Hiebert, SW; Ning, W; Washington, MK; Williams, A; Williams, CS; Wilson, KT | 1 |
| Byeon, JS; Do, EJ; Kim, IW; Kim, JH; Kim, K; Kim, KJ; Kim, MJ; Kwon, IC; Moon, DH; Myung, SJ; Park, K; Ryu, JH; Yang, DH; Yang, SK; Ye, BD; Yoon, SM | 1 |
| Cheong, SJ; Jang, D; Jeong, HJ; Jeong, MH; Kim, DW; Kim, EM; Lee, CM; Lim, ST; Sohn, MH | 1 |
| Behan, NA; Brooks, SP; Caldwell, D; Green, J; MacFarlane, AJ; Matias, FM | 1 |
| Beauchesne, E; Bélanger, M; Butterworth, RF; Chastre, A; Desjardins, P; Nguyen, BN | 1 |
| Bissonnette, M; Brasitus, T; Hart, J; Nguyen, L; Sitrin, MD; Stoiber, D; Wali, RK | 1 |
| Achenie, LE; Cui, H; Dong, M; Garg, S; Guda, K; Nambiar, PR; Rosenberg, DW | 1 |
| Kawamori, T; Sugimura, T; Uchiya, N; Wakabayashi, K | 1 |
| Fujihara, H; Kamada, N; Kusuoka, O; Masutani, M; Nakagama, H; Nakamoto, K; Nozaki, T; Sugimura, T; Suzuki, H; Tsutsumi, M; Watanabe, M | 1 |
| Biswas, S; Chytil, A; Gautam, S; Gorska, AE; Grady, WM; Moses, HL; Romero-Gallo, J; Washington, K; Wirth, PS | 1 |
| Callaway, ES; Carroll, RJ; Chapkin, RS; Davidson, LA; Dougherty, ER; Hokanson, RM; Isett, RB; Lupton, JR; Nguyen, DV; Turner, ND; Wang, N | 1 |
| Backman, V; Goldberg, MJ; Kim, YL; Koetsier, JL; Kunte, DP; Liu, Y; Roy, HK; Turzhitsky, V; Wali, RK | 1 |
| Becker, C; Fantini, MC; Galle, PR; Kiesslich, R; Lehr, HA; Neurath, MF; Nikolaev, A; Wirtz, S | 1 |
| Backman, V; Goldberg, MJ; Horwitz, J; Kim, YL; Liu, Y; Roy, HK; Turzhitsky, V; Wali, RK | 1 |
| Beauchemin, N; Jothy, S; Leung, N; Marcus, V; Olson, M; Turbide, C | 1 |
| Balik, E; Belizon, A; Ciau, N; Jain, S; Kirman, I; Remotti, H; Whelan, RL | 1 |
| Becker, C; Neufert, C; Neurath, MF | 1 |
| Barton, JK; Besselsen, DG; Drexler, W; Gerner, EW; Hariri, LP; Hermann, B; Ignatenko, NA; McNally, J; Povazay, B; Qiu, Z; Sattmann, H; Tumlinson, AR; Unterhuber, A | 1 |
| Bissahoyo, AC; Hanlon, K; Herfarth, HH; Rubinas, TC; Threadgill, DW; Uronis, JM | 1 |
| Aluri, L; Bissonnette, M; Cerda, S; Chumsangsri, A; Cohen, EE; Delgado, J; Dougherty, U; Fichera, A; Hart, J; Jagadeeswaran, S; Joseph, L; Little, N; Mustafi, R; Sehdev, A; Tretiakova, M; Yuan, W | 1 |
| Kawamori, T; Kelloff, GJ; Lubet, RA; Rao, CV; Reddy, BS; Steele, VE | 1 |
| Benya, RV; Carroll, RE; Danilkovich, AV; Green, RM; Marrero, JA; Matkowskyj, KA | 1 |
| Kelloff, GJ; Kramer, PM; Li, H; Lubet, RA; Pereira, MA; Steele, VE | 1 |
| Hirose, Y; Kelloff, G; Lubet, R; Paulson, S; Rao, CV; Reddy, BS; Seibert, K; Steele, V | 1 |
| Katayama, S; Kudoh, S; Matsuda, S | 1 |
65 other study(ies) available for azoxymethane and Disease Exacerbation
| Article | Year |
|---|---|
Upregulation of PD-1 follows tumour development in the AOM/DSS model of inflammation-induced colorectal cancer in mice.
Topics: Animals; Azoxymethane; B7-H1 Antigen; Cell Transformation, Neoplastic; Colitis; Colon; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Intestinal Mucosa; Lymphocyte Activation; Mice, Inbred C57BL; Phenotype; Programmed Cell Death 1 Ligand 2 Protein; Programmed Cell Death 1 Receptor; Signal Transduction; T-Lymphocytes; Up-Regulation | 2019 |
Orally Deliverable Nanotherapeutics for the Synergistic Treatment of Colitis-Associated Colorectal Cancer.
Topics: Administration, Oral; Animals; Apoptosis; Azoxymethane; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Colitis; Colorectal Neoplasms; Curcumin; Cytokines; Dextran Sulfate; Disease Models, Animal; Disease Progression; Drug Synergism; Female; Inflammation; Inflammation Mediators; Intestines; Irinotecan; Macrophages; Mice; Mice, Inbred C57BL; Nanoparticles; RAW 264.7 Cells | 2019 |
Temporal DNA methylation pattern and targeted therapy in colitis-associated cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Azoxymethane; bcl-Associated Death Protein; Carcinogenesis; Cell Line, Tumor; Colitis; Colon; Colonoscopy; Colorectal Neoplasms; Decitabine; Disease Models, Animal; Disease Progression; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Intestinal Mucosa; Male; Mice; Molecular Targeted Therapy; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; Up-Regulation | 2020 |
Role of transient receptor potential vanilloid subtype 4 in the regulation of azoymethane/dextran sulphate sodium-induced colitis-associated cancer in mice.
Topics: Animals; Azoxymethane; Carcinogenesis; Carcinogens; Cell Proliferation; Chemokine CXCL2; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Progression; Human Umbilical Vein Endothelial Cells; Humans; Intestinal Mucosa; Macrophages; Male; Mice; Mice, Knockout; Neoplasms, Experimental; TRPV Cation Channels | 2020 |
Lactobacillus species inhibitory effect on colorectal cancer progression through modulating the Wnt/β-catenin signaling pathway.
Topics: Animals; Apoptosis; Azoxymethane; beta Catenin; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Disease Progression; Female; Flow Cytometry; Gastrointestinal Microbiome; HT29 Cells; Humans; Inflammation; Lactobacillus; Mice; Mice, Inbred BALB C; Probiotics; Real-Time Polymerase Chain Reaction; Wnt Signaling Pathway | 2020 |
Extracellular Granzyme A Promotes Colorectal Cancer Development by Enhancing Gut Inflammation.
Topics: Acute Disease; Animals; Azoxymethane; Carcinogenesis; Chronic Disease; Colon; Colorectal Neoplasms; Cyclooxygenase 2; Cytokines; Dextran Sulfate; Disease Progression; Extracellular Space; Granzymes; Humans; Inflammasomes; Inflammation; Inflammation Mediators; Interleukin-6; Mice, Knockout; NF-kappa B; RNA, Messenger | 2020 |
Dietary Supplementation of Foxtail Millet Ameliorates Colitis-Associated Colorectal Cancer in Mice via Activation of Gut Receptors and Suppression of the STAT3 Pathway.
Topics: Animals; Azoxymethane; Basic Helix-Loop-Helix Transcription Factors; Colitis-Associated Neoplasms; Colorectal Neoplasms; Dextran Sulfate; Diet; Dietary Supplements; Disease Models, Animal; Disease Progression; Gastrointestinal Microbiome; Interleukin-17; Interleukin-6; Mice; Mice, Inbred BALB C; Oryza; Phosphorylation; Receptors, Aryl Hydrocarbon; Receptors, G-Protein-Coupled; Setaria Plant; Signal Transduction; STAT3 Transcription Factor | 2020 |
Inducible mouse models of colon cancer for the analysis of sporadic and inflammation-driven tumor progression and lymph node metastasis.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Disease Progression; Female; Inflammation; Lymphatic Metastasis; Male; Mice; Mice, Inbred C57BL | 2021 |
ARRB2 promotes colorectal cancer growth through triggering WTAP.
Topics: Animals; Azoxymethane; beta-Arrestin 2; Cell Cycle Proteins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Databases, Genetic; Dextran Sulfate; Disease Progression; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Kaplan-Meier Estimate; Male; Mice, Nude; RNA Splicing Factors; Up-Regulation | 2021 |
Small molecules related to adrenomedullin reduce tumor burden in a mouse model of colitis-associated colon cancer.
Topics: Adrenomedullin; Animals; Antineoplastic Agents; Azoxymethane; Cluster Analysis; Colitis; Colon; Colonic Neoplasms; Disease Models, Animal; Disease Progression; Gastrointestinal Agents; Mice | 2017 |
Elevated d-2-hydroxyglutarate during colitis drives progression to colorectal cancer.
Topics: Animals; Apoptosis; Azoxymethane; Biomarkers, Tumor; Biopsy; Caco-2 Cells; Cell Movement; Cell Proliferation; Cell Survival; Colitis; Colitis, Ulcerative; Colorectal Neoplasms; Dextran Sulfate; Disease Progression; Glutarates; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation; Intestinal Mucosa; Mice; Risk | 2018 |
Loss of FFAR2 promotes colon cancer by epigenetic dysregulation of inflammation suppressors.
Topics: Adenocarcinoma; Adenoma; Animals; Azoxymethane; Colitis; Colonic Neoplasms; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Dextran Sulfate; Disease Progression; Epigenesis, Genetic; Histone Deacetylases; Homeostasis; Inflammation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neoplasms, Experimental; Neutrophils; Receptors, G-Protein-Coupled | 2018 |
HIF-1α activation in myeloid cells accelerates dextran sodium sulfate-induced colitis progression in mice.
Topics: Animals; Antigens, Ly; ATP-Binding Cassette Transporters; Azoxymethane; Basic Helix-Loop-Helix Transcription Factors; Carcinogenesis; CD11b Antigen; Colitis; Colon; Dextran Sulfate; Disease Progression; Disease Susceptibility; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Mice, Knockout; Myeloid Cells; Promoter Regions, Genetic; Tumor Necrosis Factor-alpha; Von Hippel-Lindau Tumor Suppressor Protein | 2018 |
The Rac1 splice form Rac1b favors mouse colonic mucosa regeneration and contributes to intestinal cancer progression.
Topics: Animals; Azoxymethane; Carcinogenesis; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Disease Progression; Epithelial Cells; Inflammation; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Neuropeptides; rac1 GTP-Binding Protein; Signal Transduction | 2018 |
MicroRNA‑449a is a potential predictor of colitis‑associated colorectal cancer progression.
Topics: Animals; Apoptosis; Azoxymethane; Biomarkers, Tumor; Carcinogens; Case-Control Studies; Cell Proliferation; Colitis; Colorectal Neoplasms; Dextran Sulfate; Disease Progression; Female; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; Middle Aged; Prognosis; Receptor, Notch1; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2018 |
Effect of Estradiol in an Azoxymethane/Dextran Sulfate Sodium-Treated Mouse Model of Colorectal Cancer: Implication for Sex Difference in Colorectal Cancer Development.
Topics: Animals; Azoxymethane; Biomarkers; Biopsy; Carcinogens; Cell Transformation, Neoplastic; Colorectal Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; Disease Progression; Disease Susceptibility; Estradiol; Female; Humans; Immunohistochemistry; Inflammation Mediators; Male; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Sex Factors | 2019 |
DNA damage response genes mark the early transition from colitis to neoplasia in colitis-associated colon cancer.
Topics: Animals; Azoxymethane; Carcinogenesis; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Disease Progression; DNA Damage; Gene Expression Regulation; Inflammation; Inflammatory Bowel Diseases; Intestines; Male; Mice; Mice, Inbred C57BL; Microsatellite Instability; Signal Transduction | 2018 |
Role of Lymphatic Deficiency in the Pathogenesis and Progression of Inflammatory Bowel Disease to Colorectal Cancer in an Experimental Mouse Model.
Topics: Angiopoietin-2; Animals; Azoxymethane; Biomarkers; Colon; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Disease Progression; Female; Inflammatory Bowel Diseases; Lymphangiogenesis; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Tumor Necrosis Factor-alpha | 2019 |
Peptide TNIIIA2 Derived from Tenascin-C Contributes to Malignant Progression in Colitis-Associated Colorectal Cancer via β1-Integrin Activation in Fibroblasts.
Topics: Animals; Azoxymethane; Caco-2 Cells; Cell Proliferation; Colitis; Colonic Polyps; Colorectal Neoplasms; Culture Media, Conditioned; Dextran Sulfate; Disease Models, Animal; Disease Progression; Epithelial Cells; Fibroblasts; Humans; Integrin beta1; Male; Mice, Inbred ICR; Paracrine Communication; Peptides; Tenascin | 2019 |
Inhibitory role of Gas6 in intestinal tumorigenesis.
Topics: Aged; Aged, 80 and over; Animals; Azoxymethane; Bone Marrow; Bone Marrow Transplantation; Cell Proliferation; Cell Transformation, Neoplastic; Colitis; Colorectal Neoplasms; Dextran Sulfate; Disease Progression; Female; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Intercellular Signaling Peptides and Proteins; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Monocytes; NF-kappa B; Prognosis; Recombinant Proteins; RNA, Messenger; Suppressor of Cytokine Signaling 1 Protein; Suppressor of Cytokine Signaling Proteins | 2013 |
Raman endoscopy for the in situ investigation of advancing colorectal tumors in live model mice.
Topics: Age Factors; Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Disease Progression; Mice; Mice, Inbred BALB C; Spectrum Analysis, Raman | 2013 |
Simultaneous follow-up of mouse colon lesions by colonoscopy and endoluminal ultrasound biomicroscopy.
Topics: Animals; Azoxymethane; Bronchoscopes; Colon; Colonic Neoplasms; Colonoscopes; Colonoscopy; Dextran Sulfate; Disease Progression; Endosonography; Equipment Design; Female; Genes, p53; Male; Mice; Mice, 129 Strain; Mice, Knockout; Microscopy, Acoustic; Miniaturization; Predictive Value of Tests; Time Factors | 2013 |
CD24 knockout prevents colorectal cancer in chemically induced colon carcinogenesis and in APC(Min)/CD24 double knockout transgenic mice.
Topics: Adenomatous Polyposis Coli Protein; Animals; Azoxymethane; beta Catenin; Carcinogenesis; CD24 Antigen; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colitis; Colorectal Neoplasms; Cyclooxygenase 2; Dextran Sulfate; Dinoprostone; Disease Progression; Female; Gene Deletion; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Intestine, Small; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; Promoter Regions, Genetic; Signal Transduction; Tumor Burden | 2014 |
In vivo molecular mapping of the tumor microenvironment in an azoxymethane-treated mouse model of colon carcinogenesis.
Topics: Animals; Azoxymethane; Biomarkers, Tumor; Carcinogenesis; Carcinogens; Colonic Neoplasms; Colonoscopes; Colonoscopy; Disease Progression; Female; Mice; Time Factors; Tomography, Optical Coherence; Tumor Microenvironment | 2015 |
Unpolished Thai rice prevents ACF formation and dysplastic progression in AOM-induced rats and induces apoptosis through redox alteration in CaCo-2 cells.
Topics: Aberrant Crypt Foci; Animals; Apoptosis; Azoxymethane; Caco-2 Cells; Carcinogens; Cell Proliferation; Colonic Neoplasms; Diet; Disease Progression; Flow Cytometry; Humans; Male; Oryza; Oxidation-Reduction; Oxidative Stress; Precancerous Conditions; Rats; Rats, Sprague-Dawley | 2015 |
MicroRNA214 Is Associated With Progression of Ulcerative Colitis, and Inhibition Reduces Development of Colitis and Colitis-Associated Cancer in Mice.
Topics: Adaptor Proteins, Signal Transducing; Animals; Azoxymethane; Biomarkers, Tumor; Case-Control Studies; Cell Line; Colitis, Ulcerative; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Disease Progression; Gene Expression Regulation, Neoplastic; Humans; Inflammation Mediators; Interleukin-6; LIM Domain Proteins; Mice; MicroRNAs; NF-kappa B; Phosphorylation; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; RNA Interference; RNAi Therapeutics; Signal Transduction; STAT3 Transcription Factor; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 2015 |
FGF-1/-3/FGFR4 signaling in cancer-associated fibroblasts promotes tumor progression in colon cancer through Erk and MMP-7.
Topics: Animals; Azoxymethane; Cell Line, Tumor; Colitis, Ulcerative; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Disease Progression; Extracellular Signal-Regulated MAP Kinases; Fibroblast Growth Factor 1; Fibroblast Growth Factor 3; Fibroblasts; HCT116 Cells; HT29 Cells; Human Umbilical Vein Endothelial Cells; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 7; Mice; Phosphorylation; Pyrimidines; Receptor Protein-Tyrosine Kinases; Receptor, Fibroblast Growth Factor, Type 4; Receptors, Fibroblast Growth Factor; RNA Interference; RNA, Small Interfering | 2015 |
Dietary Ziziphus jujuba Fruit Influence on Aberrant Crypt Formation and Blood Cells in Colitis-Associated Colorectal Cancer in Mice.
Topics: Aberrant Crypt Foci; Adenocarcinoma; Animals; Azoxymethane; Carcinogenesis; Chemoprevention; Colitis; Colon; Colorectal Neoplasms; Dextran Sulfate; Diet; Dietary Supplements; Disease Progression; Hyperplasia; Leukocyte Count; Leukocytes; Male; Mice; Mice, Inbred C57BL; Plant Preparations; Ziziphus | 2015 |
The Impact of Dietary Energy Intake Early in Life on the Colonic Microbiota of Adult Mice.
Topics: Animals; Azoxymethane; Bacteroidetes; Caloric Restriction; Carcinogens; Colonic Neoplasms; Diet, High-Fat; Dietary Fats; Disease Progression; Energy Intake; Female; Firmicutes; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Microbiota | 2016 |
MicroRNA-17~92 inhibits colorectal cancer progression by targeting angiogenesis.
Topics: Animals; Azoxymethane; Colitis; Colorectal Neoplasms; Dextran Sulfate; Disease Progression; Gene Expression Regulation, Neoplastic; HCT116 Cells; Heterografts; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mice, Nude; Mice, Transgenic; MicroRNAs; Neoplasm Transplantation; Neovascularization, Pathologic; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; RNA, Long Noncoding; Time Factors; Vascular Endothelial Growth Factor A | 2016 |
A role for the vitamin D pathway in non-intestinal lesions in genetic and carcinogen models of colorectal cancer and in familial adenomatous polyposis.
Topics: Adenocarcinoma; Adenomatous Polyposis Coli; Animals; Azoxymethane; beta Catenin; Cell Transformation, Neoplastic; Colorectal Neoplasms; Disease Models, Animal; Disease Progression; Gardner Syndrome; Genes, APC; Genetic Predisposition to Disease; Mice, Inbred C57BL; Mice, Knockout; Mutation; Phenotype; Polymorphism, Single Nucleotide; Receptors, Calcitriol; Risk Factors; Time Factors; Vitamin D; Wnt Signaling Pathway | 2016 |
The role of Pygo2 for Wnt/ß-catenin signaling activity during intestinal tumor initiation and progression.
Topics: Adenoma; Animals; Azoxymethane; beta Catenin; Cell Proliferation; Cell Transformation, Neoplastic; Colonic Neoplasms; Disease Models, Animal; Disease Progression; Gene Expression Regulation, Neoplastic; Genes, APC; Genetic Predisposition to Disease; Intracellular Signaling Peptides and Proteins; Mice, Inbred C57BL; Mice, Knockout; Mutation; Phenotype; Proto-Oncogene Proteins c-myc; Time Factors; Tumor Burden; Wnt Signaling Pathway | 2016 |
Activins and their related proteins in colon carcinogenesis: insights from early and advanced azoxymethane rat models of colon cancer.
Topics: Activins; Adenocarcinoma; Animals; Azoxymethane; Biomarkers, Tumor; Carcinogenesis; Colonic Neoplasms; Disease Progression; Follistatin; Gene Expression; Male; Precancerous Conditions; Rats, Wistar | 2016 |
The high affinity peroxisome proliferator-activated receptor-gamma agonist RS5444 inhibits both initiation and progression of colon tumors in azoxymethane-treated mice.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colonic Neoplasms; Disease Progression; Immunohistochemistry; Mice; Mice, Inbred C57BL; PPAR gamma; Thiazolidinediones | 2008 |
Protein kinase C betaII and PKCiota/lambda: collaborating partners in colon cancer promotion and progression.
Topics: Adenoma; Animals; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colonic Neoplasms; Disease Progression; Genes, APC; Humans; Isoenzymes; Mice; Mice, Knockout; Mice, Transgenic; Protein Kinase C; Protein Kinase C beta | 2009 |
The absence of LPA2 attenuates tumor formation in an experimental model of colitis-associated cancer.
Topics: Animals; Azoxymethane; beta Catenin; Cell Proliferation; Chemokine CCL2; Colitis; Colonic Neoplasms; Cyclooxygenase 2; Cytokines; Disease Progression; Genes, APC; Kruppel-Like Transcription Factors; Lipopolysaccharides; Macrophage Migration-Inhibitory Factors; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Lysophosphatidic Acid | 2009 |
Lack of efficacy of blueberry in nutritional prevention of azoxymethane-initiated cancers of rat small intestine and colon.
Topics: Adenocarcinoma; Adenomatous Polyps; Animals; Azoxymethane; Blueberry Plants; C-Peptide; Colonic Neoplasms; Disease Models, Animal; Disease Progression; Duodenal Neoplasms; Female; Incidence; Male; Nutrition Therapy; Rats; Rats, Sprague-Dawley | 2009 |
Expression profiles of proliferative and antiapoptotic genes in sporadic and colitis-related mouse colon cancer models.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Azoxymethane; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Cell Cycle Proteins; Cell Proliferation; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Cyclooxygenase 2; Dextran Sulfate; Disease Models, Animal; Disease Progression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Inhibitor of Apoptosis Proteins; Male; Mice; Mice, Inbred ICR; Microdissection; Microtubule-Associated Proteins; Nitric Oxide Synthase Type II; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-myb; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; Survivin; Telomerase; Transcription Factor 4 | 2010 |
Colitis-associated cancer is dependent on the interplay between the hemostatic and inflammatory systems and supported by integrin alpha(M)beta(2) engagement of fibrinogen.
Topics: Adenoma; Animals; Azoxymethane; Carcinogens; Cell Growth Processes; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Cytokines; Dextran Sulfate; Disease Progression; Fibronectins; Hemostasis; Macrophage-1 Antigen; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic | 2010 |
Identification of gene expression profiles correlated to tumor progression in a preclinical model of colon carcinogenesis.
Topics: Animals; Azoxymethane; Biomarkers, Tumor; Carcinogens; Cell Transformation, Neoplastic; Colonic Neoplasms; Disease Models, Animal; Disease Progression; Gene Expression Profiling; Male; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2010 |
MTGR1 is required for tumorigenesis in the murine AOM/DSS colitis-associated carcinoma model.
Topics: Animals; Azoxymethane; Carcinoma; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Disease Progression; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Repressor Proteins | 2011 |
Application of near-infrared fluorescence imaging using a polymeric nanoparticle-based probe for the diagnosis and therapeutic monitoring of colon cancer.
Topics: Adenocarcinoma; Animals; Azoxymethane; Cell Line, Tumor; Colon; Colonic Neoplasms; Diagnostic Imaging; Disease Models, Animal; Disease Progression; Drug Therapy; Enzyme Inhibitors; Fluorescent Dyes; Humans; Male; Matrix Metalloproteinase 7; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred Strains; Nanoparticles; Treatment Outcome; Xenograft Model Antitumor Assays | 2011 |
Optical imaging of MMP expression and cancer progression in an inflammation-induced colon cancer model.
Topics: Animals; Azoxymethane; beta Catenin; Blotting, Western; Carbocyanines; Carcinogens; Colonic Neoplasms; Dextran Sulfate; Diagnostic Imaging; Disease Models, Animal; Disease Progression; Immunoenzyme Techniques; Inflammation; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Peptide Fragments | 2012 |
Dietary folate does not significantly affect the intestinal microbiome, inflammation or tumorigenesis in azoxymethane-dextran sodium sulphate-treated mice.
Topics: Animals; Azoxymethane; Biomarkers; Colitis, Ulcerative; Colon; Colonic Neoplasms; Dextran Sulfate; Dextrans; Diet; Disease Progression; Folic Acid; Inflammation; Male; Mice; Mice, Inbred C57BL; Microbiota; Neoplasms; RNA, Ribosomal, 16S; Sulfates | 2013 |
Inflammatory cascades driven by tumor necrosis factor-alpha play a major role in the progression of acute liver failure and its neurological complications.
Topics: Ammonia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoxymethane; CD40 Ligand; Cerebrum; Disease Progression; Etanercept; Hepatic Encephalopathy; Immunoglobulin G; Interleukin-6; Liver; Liver Failure, Acute; Male; Mice; Microglia; Oxidative Stress; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2012 |
Ursodeoxycholic acid inhibits the initiation and postinitiation phases of azoxymethane-induced colonic tumor development.
Topics: Animals; Azoxymethane; Cholagogues and Choleretics; Colonic Neoplasms; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Incidence; Male; Rats; Rats, Inbred F344; Time Factors; Treatment Outcome; Ursodeoxycholic Acid | 2002 |
Multistage gene expression profiling in a differentially susceptible mouse colon cancer model.
Topics: Adenocarcinoma; Algorithms; Alkylating Agents; Animals; Azoxymethane; Carcinogens; Cluster Analysis; Colonic Neoplasms; Disease Progression; DNA, Complementary; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Male; Mice; Mice, Inbred A; Mice, Inbred AKR; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Species Specificity; Subtraction Technique | 2003 |
Enhancement of colon carcinogenesis by prostaglandin E2 administration.
Topics: Adenocarcinoma; Animals; Apoptosis; Azoxymethane; Bromodeoxyuridine; Carcinogens; Colon; Colonic Neoplasms; Dinoprostone; Disease Progression; DNA Primers; Incidence; Injections, Intraperitoneal; Intestinal Mucosa; Male; Rats; Rats, Inbred F344; Receptors, Prostaglandin E; Reverse Transcriptase Polymerase Chain Reaction | 2003 |
Parp-1 deficiency implicated in colon and liver tumorigenesis induced by azoxymethane.
Topics: Adenocarcinoma; Adenoma; Animals; Azoxymethane; beta Catenin; Carcinogens; Cell Transformation, Neoplastic; Colonic Neoplasms; Cytoskeletal Proteins; Disease Progression; DNA Primers; Female; Homozygote; Liver Neoplasms, Experimental; Mice; Mice, Inbred ICR; Mice, Knockout; Poly(ADP-ribose) Polymerases; Trans-Activators | 2003 |
Transforming growth factor beta receptor type II inactivation promotes the establishment and progression of colon cancer.
Topics: Animals; Apoptosis; Azoxymethane; Carcinogens; Carrier Proteins; Cell Differentiation; Cell Division; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Cyclooxygenase 2; Disease Models, Animal; Disease Progression; Fatty Acid-Binding Proteins; Female; Gene Silencing; Genetic Predisposition to Disease; Isoenzymes; Male; Mice; Mutation; Prostaglandin-Endoperoxide Synthases; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta | 2004 |
Chemopreventive n-3 polyunsaturated fatty acids reprogram genetic signatures during colon cancer initiation and progression in the rat.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Carcinogens; Cell Differentiation; Colonic Neoplasms; Disease Progression; DNA Adducts; Down-Regulation; Eating; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Fatty Acids, Unsaturated; Fish Oils; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Male; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Triglycerides; Up-Regulation; Weight Gain | 2004 |
Increased microvascular blood content is an early event in colon carcinogenesis.
Topics: Adenoma; Animals; Azoxymethane; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Disease Models, Animal; Disease Progression; Hemoglobins; Humans; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Microcirculation; Optics and Photonics; Pilot Projects; Precancerous Conditions; Rats; Rats, Inbred F344; Scattering, Radiation | 2005 |
In vivo imaging of colitis and colon cancer development in mice using high resolution chromoendoscopy.
Topics: Animals; Azoxymethane; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Colonoscopes; Colonoscopy; Dextran Sulfate; Disease Models, Animal; Disease Progression; Intestinal Mucosa; Mice; Mice, Inbred Strains; Severity of Illness Index | 2005 |
Risk stratification of colon carcinogenesis through enhanced backscattering spectroscopy analysis of the uninvolved colonic mucosa.
Topics: Animals; Azoxymethane; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Disease Models, Animal; Disease Progression; Equipment Design; Female; Humans; Light; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Middle Aged; Pilot Projects; Predictive Value of Tests; Radiography; Rats; Rats, Inbred F344; Risk Factors; Scattering, Radiation; Sensitivity and Specificity; Spectrum Analysis | 2006 |
Deletion of the carcinoembryonic antigen-related cell adhesion molecule 1 (Ceacam1) gene contributes to colon tumor progression in a murine model of carcinogenesis.
Topics: Animals; Azoxymethane; Blotting, Western; Carcinoembryonic Antigen; Carcinogens; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Disease Models, Animal; Disease Progression; Gene Targeting; Genotype; Mice; Mice, Inbred C57BL; Mice, Knockout | 2006 |
Insulin-like growth factor binding protein-3 inhibits colitis-induced carcinogenesis.
Topics: Animals; Azoxymethane; Colitis; Colonic Neoplasms; Disease Progression; Female; Follow-Up Studies; Insulin-Like Growth Factor Binding Protein 3; Mice; Mice, Transgenic; Neoplasms, Experimental; Treatment Outcome | 2007 |
An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progression.
Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Disease Progression; Inflammation Mediators; Mice; Mutagens | 2007 |
Serial endoscopy in azoxymethane treated mice using ultra-high resolution optical coherence tomography.
Topics: Adenoma; Animals; Azoxymethane; Colon; Colorectal Neoplasms; Disease Models, Animal; Disease Progression; Endoscopy, Gastrointestinal; Gastrointestinal Neoplasms; Mice; Tomography, Optical Coherence | 2007 |
Flat colorectal cancers are genetically determined and progress to invasion without going through a polypoid stage.
Topics: Animals; Azoxymethane; beta Catenin; Colorectal Neoplasms; Disease Models, Animal; Disease Progression; DNA Mutational Analysis; Endoscopy; Humans; Mice; Neoplasm Invasiveness; Polyploidy | 2007 |
Epidermal growth factor receptor controls flat dysplastic aberrant crypt foci development and colon cancer progression in the rat azoxymethane model.
Topics: Animals; Azoxymethane; CCAAT-Enhancer-Binding Protein-beta; Colonic Neoplasms; Cyclin D; Cyclins; Disease Progression; ErbB Receptors; Gefitinib; Male; Precancerous Conditions; Quinazolines; Rats; Rats, Inbred F344; STAT3 Transcription Factor; Transcription Factor AP-1 | 2008 |
Chemopreventive efficacy of sulindac sulfone against colon cancer depends on time of administration during carcinogenic process.
Topics: Adenocarcinoma; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colonic Neoplasms; Cyclooxygenase Inhibitors; Disease Progression; Dose-Response Relationship, Drug; Drug Administration Schedule; Male; Neoplasm Invasiveness; Rats; Rats, Inbred F344; Sulindac; Weight Gain | 1999 |
Azoxymethane-induced fulminant hepatic failure in C57BL/6J mice: characterization of a new animal model.
Topics: Animals; Azoxymethane; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Hepatic Encephalopathy; Liver; Liver Failure; Male; Mice; Mice, Inbred C57BL | 1999 |
Termination of piroxicam treatment and the occurrence of azoxymethane-induced colon cancer in rats.
Topics: Adenocarcinoma; Adenoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Azoxymethane; Body Weight; Carcinogenicity Tests; Carcinogens; Cell Division; Colonic Neoplasms; Disease Progression; Drug Administration Schedule; Intestinal Mucosa; Male; Piroxicam; Precancerous Conditions; Rats; Rats, Inbred F344 | 1999 |
Chemoprevention of colon cancer by specific cyclooxygenase-2 inhibitor, celecoxib, administered during different stages of carcinogenesis.
Topics: Administration, Oral; Animals; Anticarcinogenic Agents; Azoxymethane; Celecoxib; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Progression; Isoenzymes; Male; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Inbred F344; Sulfonamides; Time Factors | 2000 |
Enhanced formation of azoxymethane-induced colorectal adenocarcinoma in gammadelta T lymphocyte-deficient mice.
Topics: Adenocarcinoma; Animals; Azoxymethane; Colorectal Neoplasms; Disease Progression; Homozygote; Hyperplasia; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Antigen, T-Cell, gamma-delta; T-Lymphocytes | 2001 |