azoxymethane has been researched along with Colonic Neoplasms in 1100 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 89 (8.09) | 18.7374 |
| 1990's | 235 (21.36) | 18.2507 |
| 2000's | 352 (32.00) | 29.6817 |
| 2010's | 355 (32.27) | 24.3611 |
| 2020's | 69 (6.27) | 2.80 |
| Authors | Studies |
|---|---|
| Hashimoto, S; Kojima, H; Kubota, A; Maeda, H; Miyashita, K; Mutoh, M; Ohta, T; Ono, S; Tanaka, T; Terasaki, M | 1 |
| Canter, JA; Cao, L; Carlson, BA; Davis, CD; Ernst, SE; Gladyshev, VN; Grysczyk, L; Hatfield, DL; Peters, KM; Thielman, NRJ; Tsuji, PA; Udofe, P; Yu, Y | 1 |
| Chen, GQ; Chen, J; Li, Z; Liu, G; Wu, F; Zhang, S; Zhang, Y | 1 |
| Aboulthana, WM; Essawy, EA; Salama, AH; Saleh, MH; Shousha, WG | 1 |
| Allaman, MM; Asim, M; Barry, DP; Coburn, LA; Delgado, AG; Finley, JL; Gobert, AP; Latour, YL; Luis, PB; McNamara, KM; Piazuelo, MB; Schneider, C; Sierra, JC; Singh, K; Smith, TM; Washington, MK; Wilson, KT; Zhao, S | 1 |
| Aktepe, OH; Dizdar, O; Guner, G; Guven, DC; Kurtulan, O; Ozercan, IH; Sahin, TK; Yalcin, S; Yeter, HH | 1 |
| Cho, YW; Kwon, YH | 1 |
| Birod, K; Brachtendorf, S; El-Hindi, K; Grösch, S; Hartel, JC; Merz, N; Oertel, S; Schäufele, TJ; Schiffmann, S; Scholich, K; Thomas, D; Trautmann, S; Ulshöfer, T; Utermöhlen, O; Weigert, A | 1 |
| Ashby, J; Browning, DD; Hou, Y; Islam, BN; Li, H; Liu, K; Sharman, SK; Vega, KJ; Wang, R | 1 |
| Kimura, Y; Sumiyoshi, M | 1 |
| Jiang, S; Ma, F; Mu, G; Qian, F; Song, Y; Sun, M; Tuo, Y; Wang, A | 1 |
| Bermúdez, F; Doello, K; López-Jurado, M; Martínez, R; Melguizo, C; Mesas, C; Ortiz, R; Porres, JM; Prados, J; Quiñonero, F | 1 |
| Choi, SI; Jang, JY; Kim, N; Lee, HN; Nam, RH; Song, CH | 1 |
| Begun, J; Davies, JM; Florin, TH; Giri, R; Hasnain, SZ; McGuckin, MA; Sheng, YH; Wang, R; Wong, KY; Yang, Y | 1 |
| Bailey, MT; Chatelaine, HA; Hatzakis, E; Kopec, RE; Mathé, EA; McElroy, J; Olivo-Marston, S; Ramazani, CA; Spencer, K | 1 |
| Cecil, D; Corulli, LR; Disis, ML; Rodmaker, ER; Waggie, KS; Walsh, C | 1 |
| Ajayi, BO; Ajeigbe, OF; Anyebe, DA; Farombi, EO; Maruf, OR; Opafunso, IT | 1 |
| Di, W; Li, X; Yang, Q | 1 |
| Chang, Y; Chen, H; Kang, J; Liang, X; Sun, M; Xiao, T; Zhang, J | 1 |
| Chen, C; Chen, G; Chen, X; Du, J; Gao, Y; Li, W; Ning, H; Pang, L; Qi, Y; Shen, W; Shi, R; Sui, X; Sun, Y; Wang, H; Wu, Y; Zhai, W; Zhao, W; Zhou, X | 1 |
| Albuquerque, M; Collard, MK; Dumay, A; Freund, JN; Guedj, N; Hugot, JP; Ogier-Denis, E; Panis, Y; Roy, M; Tourneur-Marsille, J; Treton, X; Uzzan, M | 1 |
| Baker, K; Cotter, PD; Cronin, P; Gahan, CGM; Houston, A; Hyland, NP; Joyce, SA; Keane, JM; Melgar, S; Walsh, CJ | 1 |
| Bouznad, N; Brocker, T; Friedrich, V; Garzetti, D; Hermeking, H; Krebs, S; Krug, AB; Lutz, K; Matzek, D; Metzger, R; Öllinger, R; Rad, R; Rokavec, M; Schäfer, Y; Stecher, B; von Armansperg, B; Winheim, E; Winter, L | 1 |
| Chen, Y; Kang, C; Li, J; Liu, Z; Zhang, Q; Zhu, W | 1 |
| An, SY; Kim, J; Kim, SW; Lee, DB; Pyo, SS; Yoon, DW | 1 |
| Jiang, Q; Jones-Hall, Y; Liu, KY; Nakatsu, CH; Wang, Q | 1 |
| Kimura, Y; Okuda, T; Taniguchi, M | 1 |
| Kimura, Y; Sumiyoshi, M; Taniguchi, M | 1 |
| Feng, YL; Jia, J; Luo, YY; Ouyang, H; Wan, MQ; Xie, XX; Yang, X; Yu, J | 1 |
| Fujisawa, Y; Kitamura, H; Nakagawa, N; Nishida, K; Xiang, H | 1 |
| Kang, X; Kwong, TNY; Lam, TYT; Lin, Y; Liu, C; Ng, SK; Ni, Y; Sung, JJY; Wei, H; Wong, SH; Wu, WKK; Yu, J; Zhou, Y | 1 |
| Chung, JH; Hong, GH; Lee, SY; Park, KY | 1 |
| Al-Omari, M; Al-Omari, T; Al-Qauod, K; Batainah, N; Janciauskiene, S; Olejnicka, B | 1 |
| Beck, S; Crossland, NA; Crott, JW; Guo, W; Lo, M; Mason, JB; Tan, WY; Zhang, C | 1 |
| Arias-Romero, LE; Callejas, BE; Chirino, YI; Delgado-Buenrostro, NL; León-Cabrera, SA; Martínez-Saucedo, D; Mendoza-Rodríguez, MG; Pérez-Plasencia, C; Reyes-Martínez, S; Rodríguez-Sosa, M; Sánchez-Barrera, CA; Terrazas, LI; Vaca-Paniagua, F; Villamar-Cruz, O | 1 |
| Chen, X; Decker, EA; Kim, D; Ma, Q; Park, Y; Qi, W; Sanidad, KZ; Yang, R; Zhang, G; Zhang, J | 1 |
| Biddick, L; Janakiram, NB; Li, Q; Lightfoot, S; Lubet, RA; Madka, V; Miller, MS; Mohammed, A; Rao, CV; Sei, S; Singh, A; Steele, VE; Suen, CS; Zhang, Y | 1 |
| Guo, M; Li, Z | 1 |
| Keleş, ÖF; Kömüroğlu, AU; Uyar, A; Yaman, T; Yener, Z | 1 |
| Oyama, T; Sugie, S; Tanaka, T | 1 |
| Li, J; Li, W; Ma, Y; Qian, J; Wang, C; Wang, H; Yang, H; Zhang, X; Zhao, X | 1 |
| Asch, AS; Kumar, G; Lightfoot, S; Madka, V; Mohammed, A; Pathuri, G; Rao, CV; Steele, VE; Zhang, Y | 1 |
| Bautista, EJ; Chen, Y; Nakanishi, M; Qendro, V; Rosenberg, DW; Sodergren, E; Weinstock, GM | 1 |
| Deguchi, A; Kato, S; Kawanishi, S; Maebashi, U; Matsumoto, K; Morita, A; Motoyoshi, A; Nakahara, T; Nakamoto, T; Nishimura, K; Sueyoshi, M; Takata, K; Tominaga, M | 1 |
| Carney, B; Coffey, RJ; Houghton, JL; Jae Huh, W; McKinley, ET; Niitsu, H | 1 |
| Athavale, D; Bhat, MK; Chouhan, S; Deshmukh, B; Mayengbam, SS; Ramteke, P; Singh, S | 1 |
| Allred, CD; Allred, KF; Callaway, ES; Chapkin, RS; Davidson, LA; DeLuca, JAA; Garcia-Villatoro, EL; Hensel, ME; Ivanov, I; Jayaraman, A; Menon, R; Safe, SH | 1 |
| Berhow, M; Gonzalez de Mejia, E; Luna-Vital, D; Mazewski, C | 1 |
| Hong, JE; Hwang, S; Jo, M; Lee, CG; Park, CO; Rhee, KJ | 1 |
| Crott, JW; Kane, AV; Koh, GY; Wu, X | 1 |
| Huh, TG; Jeong, BJ; Jeong, JS; Kim, HY; Lee, JS; Park, KY; Song, JL | 1 |
| Ibuka, T; Kato, J; Kubota, M; Mizutani, T; Sakai, H; Shimizu, M; Shirakami, Y | 1 |
| Qiao, PF; Yao, L; Zeng, ZL | 1 |
| Aboulthana, WM; El-Feky, AM; Hassan, AK; Ibrahim, NE; Madboli, AA; Osman, NM; Seif, MM; Youssef, AM | 1 |
| Diao, F; Li, X; Li, Y; Mei, Q; Niu, Y; Sun, Y; Zhou, H | 1 |
| Bars-Cortina, D; Macià, A; Martínez-Bardají, A; Motilva, MJ; Piñol-Felis, C | 1 |
| Baba, K; Kimura, Y; Kiyoi, T; Sumiyoshi, M | 1 |
| Gao, WQ; Gui, L; Ji, L; Liu, M; Ma, B; Wang, C; Wang, Y; Yan, J; Yin, P | 1 |
| Abdelhady, HA; El-Gamal, MM; Mona, MM; Salim, EI | 1 |
| He, C; Hu, M; Li, P; Li, Y; Liu, Q; Liu, S; Shen, J; Sun, Y; Xiao, P; Yang, C; Zhang, Z | 1 |
| Bi, X; Buraschi, S; Chen, Y; Fan, D; Iozzo, RV; Mao, L; Yang, J; Yue, J; Zhang, Q; Zhou, H | 1 |
| Deng, A; Li, X; Qin, H; Song, H; Tang, X; Wang, W; Wang, Y; Wu, L; Zhang, H | 1 |
| Devaraj, H; Seetha, A; Sudhandiran, G | 1 |
| Bayrer, JR; Bisanz, JE; Bowman, C; Braverman, KN; Chawla, A; Escalante, V; Ganeshan, K; Man, K; Patterson, A; Tian, Y; Turnbaugh, PJ; Wang, B | 1 |
| Boonsanay, V; Brabletz, T; Greten, FR; Heichler, C; Neufert, C; Neurath, MF; Scheibe, K | 1 |
| Im, S; Jiang, Q; Jones-Hall, Y; Nakatsu, C; Yang, C; Zhao, Y | 1 |
| Ando, S; Fukamachi, K; Iinuma, M; Matsumoto, H; Suzui, M; Yoshimoto, E | 1 |
| Bodiga, VL; Jeevigunta, NLL; Velagapudi, K | 1 |
| Basu, S; Dannenberg, AJ; Ito, N; Makino, T; Montrose, DC | 1 |
| Lee, HJ; Lee, SM; Lim, YI; Park, ES; Park, KY; Yu, T | 1 |
| Ibuka, T; Ideta, T; Kochi, T; Kubota, M; Nakanishi, T; Ozawa, N; Sakai, H; Shimizu, M; Shirakami, Y; Tanaka, T | 1 |
| Ali, DA; Arab, HH; Ashour, AM; Kabel, AM | 1 |
| Chen, C; Chen, J; Chen, R; Fang, L; Guo, C; Guo, D; Sang, T; Wang, X; Wang, Y; Wu, J | 1 |
| Ho, CT; Lee, PS; Nagabhushanam, K; Pan, MH | 1 |
| Ganta, V; Janakiram, NB; Kumar, G; Lightfoot, S; Lubet, R; Madka, V; Mohammed, A; Panneerselvam, J; Pathuri, G; Rao, CV; Steele, VE; Suen, CS; Zhang, Y | 1 |
| Arias-Romero, LE; Ávila-Moreno, F; Chirino, YI; Delgado-Buenrostro, NL; Delgado-Ramirez, YG; Gutierrez-Cirlos, EB; Ledesma-Soto, Y; Leon-Cabrera, SA; Molina-Guzman, E; Pérez-Plasencia, CG; Rodríguez-Sosa, M; Terrazas, LI; Vaca-Paniagua, F; Vázquez-Sandoval, A | 1 |
| Bellamkonda, K; Chandrashekar, NK; Douglas, D; Osman, J; Savari, S; Sjölander, A | 1 |
| Dai, X; Gui, G; Li, K; Liu, J; Xiao, Y; Yang, H | 1 |
| Dunger, N; Endlicher, E; Goelder, S; Hartmann, A; Kunst, C; Lippert, E; Messmann, H; Obermeier, F; Rogler, G; Ruemmele, P | 1 |
| Bielawski, J; Chan, OTM; Furuya, H; Iino, K; Kawamori, T; Pagano, I; Shimizu, Y; Tamashiro, PM | 1 |
| Bujaidar, EM; Chino, XMS; Garzón, VRV; González, IÁ; Hoyos, RB; Martínez, CJ; Ortiz, GD; Treviño, SV | 1 |
| DeHamer, R; Hoh, E; Hong, MY; Kang, B; Kim, JY; Lumibao, J | 1 |
| He, L; Luan, Z; Lv, H; Qian, J; Tan, B; Wang, H; Xin, Y; Yang, H; Yu, S; Zhao, X; Zhou, W; Zhou, Y | 1 |
| Chang, EB; Du, W; He, TC; Huang, WH; Musch, MW; Wan, JY; Wang, CZ; Wang, Y; Williams, S; Yu, C; Yuan, CS; Zhang, CF | 1 |
| Faouzi, M; Fleig, A; Furuya, H; Horgen, FD; Huang, J; Kawabata, KG; Kawamori, T; Monteilh-Zoller, M; Penner, R; Zhang, Z | 1 |
| Kamsani, NE; Md Nasir, NL; Md Tohid, SF; Mohtarrudin, N; Othman, F; Zakaria, ZA | 1 |
| Dey, M; Liu, Y | 1 |
| González de Mejía, E; Loarca-Piña, G; Luna-Vital, DA | 1 |
| Alfwuaires, M; Alzahrani, AM; Bani Ismail, M; Hanieh, H; Ibrahim, HM; Mohafez, O; Shehata, T | 1 |
| Blackburn, C; Bulek, K; Carman, J; Chen, X; Hamilton, TA; Hao, Y; Huang, YH; Kalady, MF; Li, X; Liu, C; Ouyang, W; Su, B; Wang, X; Wang, Z; Wu, L; Yang, WP; Zepp, JA; Zhao, J; Zhu, J | 1 |
| García-Sanmartín, J; Martínez, A; Martínez-Herrero, S; Narro-Íñiguez, J; Ochoa-Callejero, L; Rubio-Mediavilla, S | 1 |
| Lee, HN; Surh, YJ; Zhong, X | 1 |
| Agle, KA; Chen, X; Drobyski, WR; Huang, YW; Oshima, K; Pan, P; Wang, LS; Yearsley, MM; Yu, J; Zhang, J | 1 |
| Cheng, D; Fang, M; Gao, L; Gaspar, JM; Guo, Y; Hart, RP; Kong, AN; Li, W; Sargsyan, D; Su, ZY; Verzi, MP; Wang, C; Wu, R; Yin, R; Zhang, C | 1 |
| Byeon, SE; Cho, JY; Hong, S; Kim, J; Kim, JH; Lee, J; Yang, WS; Yi, YS | 1 |
| Ding, Y; Du, Q; Hu, R; Liu, X; Zhang, X; Zhou, W | 1 |
| Kim, JK; Park, JH | 1 |
| Callaway, E; Chapkin, RS; Goldsby, J; Ivanov, I; McLean, MW; Triff, K | 1 |
| Agah, S; Alizadeh, AM; Bahmani, S; Ghasemian, F; Khavari-Daneshvar, H; Mosavi, M; Ranji, P; Tavassoli, A | 1 |
| Currey, N; Dahlstrom, JE; Daniel, JJ; Kohonen-Corish, MRJ; Mladenova, DN | 1 |
| Fang, J; Qin, Y; Weng, Z; Xie, Y; Yuan, T | 1 |
| Crott, JW; Kane, A; Koh, GY; Lee, K; Mason, JB; Roper, J; Wu, X; Xu, Q | 1 |
| Brambilla, SR; Camargo, JA; Carvalheira, JBC; Mendes, MCS; Paulino, DS; Persinoti, GF | 1 |
| Andreatos, N; Angelou, A; Antoniou, E; Damaskos, C; Garmpis, N; Margonis, GA; Papalois, A; Theocharis, S; Theodoropoulos, G; Xiao, W; Yuan, C; Zacharioudaki, A; Zografos, G | 1 |
| Allaman, MM; Asim, M; Barry, DP; Cleveland, JL; Coburn, LA; Delgado, AG; Gobert, AP; Luis, PB; Piazuelo, MB; Schneider, C; Shi, C; Singh, K; Washington, MK; Wilson, KT | 1 |
| Dubé, PE; Girish, N; Liu, CY; Polk, DB; Washington, MK | 1 |
| Briedé, JJ; Chirino, YI; de Kok, TM; Garduño-Balderas, LG; Jetten, MJ; Jonkhout, MCM; Proquin, H; van Loveren, H | 1 |
| Bravou, V; Champeris Tsaniras, S; Giannou, AD; Gorgoulis, VG; Karousi, F; Lalioti, ME; Lygerou, Z; Nikou, S; Pateras, IS; Patmanidi, AL; Petropoulos, M; Stathopoulos, GT; Taraviras, S; Tserou, P; Villiou, M | 1 |
| Attaix, D; Blas-Y-Estrada, F; Blot, A; Chantelauze, C; Chevolleau, S; Corpet, DE; Debrauwer, L; Dupuy, J; Durand, D; Guéraud, F; Kuhnle, GGC; Martin, OCB; Meunier, N; Naud, N; Pierre, FHF; Pujos-Guillot, E; Santé-Lhoutellier, V; Sayd, T; Schlich, P; Scislowski, V; Taché, S; Urbano, C; Viala, D | 1 |
| Chen, Z; Gao, J; Geng, T; Liu, K; Song, J; Song, W; Tang, H; Wang, M; Yi, S; Zhou, W | 1 |
| Chastre, E; Jordan, P; Kotelevets, L; Lehy, T; Mamadou, G; Walker, F | 1 |
| Bianco, G; Caruso, MG; D'Alessandro, R; DE Nunzio, V; Gigante, I; Messa, C; Notarnicola, M; Refolo, MG; Scavo, MP; Tafaro, A; Tutino, V | 1 |
| Choi, JH; Park, KY; Seo, JH; Song, JL | 1 |
| Almoghrabi, A; Backman, V; Bissonnette, M; Dougherty, U; Eshein, A; Gomes, A; Hart, J; Konda, V; Pabla, B; Roy, HK; Ruderman, S; Singh, A; Valuckaite, V | 1 |
| Booth, CJ; D'Souza, SS; Kartchner, BJ; Lee, EC; Malizia, RA; O'Connor, W; Sharp, SP; Stain, SC; Walrath, T | 1 |
| Cao, Q; Chen, M; Chen, T; Ji, W; Peng, S; Qiu, Y; Que, B; Yuan, G; Zhang, H | 1 |
| Abbott, CA; Aburto-Medina, A; Ball, AS; Le Leu, RK; Nurdin, SU; Stangoulis, JCR; Young, GP | 1 |
| Kim, BG; Kim, DW; Kim, JS; Kim, JW; Koh, SJ; Lee, KL | 1 |
| Álvarez-González, I; Baltiérrez-Hoyos, R; Dávila-Ortiz, G; Garduño-Siciliano, L; Jiménez Martínez, C; León-Espinosa, EB; Madrigal-Bujaidar, E; Sánchez-Chino, XM; Vásquez-Garzón, VR | 1 |
| Balboa, MA; Balsinde, J; Cubero, Á; García-Rostán, G; Győrffy, B; Lordén, G; Meana, C; Orduña, A; Peña, L | 1 |
| Callaway, ES; Chapkin, RS; Ivanov, I; Jayaprakasha, GK; Kim, E; Patil, BS; Turner, ND; Wright, GA; Zoh, RS | 1 |
| Araki, K; Asano, K; Deguchi, Y; Mikami, T; Nakagata, N; Nakagawa, Y; Nakano, H; Nishina, T; Ohmuraya, M; Sakuma, T; Tanaka, M; Yamamoto, T | 1 |
| Aleksandersen, M; Berntsen, HF; Hansen, KEA; Johanson, SM; Paulsen, JE; Ropstad, E; Steppeler, C; Sødring, M; Zimmer, KE; Østby, GC | 1 |
| Cai, X; Han, Y; Neto, C; Song, M; Tang, Z; Tata, A; Wang, Q; Wu, X; Xiao, H | 1 |
| Al-Attabi, Z; Al-Malky, RN; Al-Maskari, SNM; Al-Ruqaishi, BRS; Ali, A; Deth, RC; Dong, J; Guizani, N; Padmanabhan, S; Rahman, MS; Taranikanti, V; Waly, MI | 1 |
| Arruda, SF; Campos, NA; da Cunha, MSB | 1 |
| Asami, Y; Hattori, N; Imai, T; Ishida, T; Kimura, K; Kobayashi, K; Mori, A; Mori, T; Niwa, T; Ushijima, T | 1 |
| Chen, S; Jing, X; Li, M; Liu, H; Liu, Y; Sun, B; Sun, T; Tian, Y; Wang, H; Yang, C; Zhang, Q; Zhao, J; Zhao, Y; Zong, S | 1 |
| Cao, H; Dong, W; Liu, L; Liu, T; Ma, J; Wang, B; Wang, D; Wang, S; Xie, R; Zheng, R | 1 |
| Chen, H; De Lisio, M; Emmons, R; Hernández-Saavedra, D; Kriska, A; Pan, YX; Xu, G | 1 |
| Kamishima, M; Kawamura, T; Konno, H; Kurachi, K; Sakata, M; Setoh, M; Suzuki, K; Suzuki, Y; Takeuchi, H; Yamamoto, M | 1 |
| Hwang, S; Khalmuratova, R; Kim, JH; Kim, YS; Koh, SJ; Lee, GY; Lee, M; Park, JW; Shin, HW; Yoon, DW | 1 |
| Ha, T; Kim, CH; Lee, BS; Lee, J; Lee, SH; Lou, Z | 1 |
| Han, W; Li, W; Lv, X; Wang, H; Zhao, X | 1 |
| Bader, JE; Carson, JA; Carson, M; Chatzistamou, I; Enos, RT; Kubinak, JL; Murphy, EA; Nagarkatti, M; Pena, MM; Sougiannis, AT; VanderVeen, BN; Velazquez, KT; Walla, M | 1 |
| Bissonnette, M; Chen, CT; Chen, NT; Dougherty, U; Hart, J; Lo, LW; Souris, JS; Waller, JV; Zhang, HJ | 1 |
| Bak, MJ; Jeong, WS; Truong, VL | 1 |
| Araki, A; Asao, H; Gazi, MY; Jin, L; Nara, H; Nemoto, N; Takeda, Y | 1 |
| Bensard, C; Chen, X; Rutter, J; Schell, JC; Swanson, E; Tantin, D; Vázquez-Arreguín, K | 1 |
| Angelou, A; Antoniou, E; Buettner, S; Faateh, M; Margonis, GA; Papalois, AE; Pikouli, A; Pikoulis, E; Theocharis, S; Theodoropoulos, G; Ventin, M; Wang, J; Zografos, GC | 1 |
| Andrés, E; Batlle, R; Berenguer-Llergo, A; Gonzalez, L; Gutierrez-Prat, N; Igea, A; Llonch, E; Nebreda, AR | 1 |
| Cherubini, F; Colantoni, A; De Simone, V; Di Fusco, D; Di Grazia, A; Dinallo, V; Fearon, ER; Franzè, E; Laudisi, F; Monteleone, G; Monteleone, I; Ortenzi, A; Stolfi, C | 1 |
| Biemond, I; D'Haens, G; de Jonge-Muller, ES; Ederveen, A; Groothuis, P; Hardwick, JC; Heijmans, J; Hommes, DW; Muncan, V; Roelofs, J; Rosekrans, SL; van den Brink, GR; van Lidth de Jeude, JF; Wielenga, MC | 1 |
| Backman, V; Kunte, D; Mutyal, NN; Radosevich, A; Roy, HK; Stypula, Y; Tiwari, AK; Wali, R | 1 |
| Fitch, MD; Fleming, SE; Sikalidis, AK | 2 |
| Homanics, GE; Lazo, JS; Zimmerman, MW | 1 |
| Al-Rabadi, L; Bugni, JM; Karagiannides, I; Pothoulakis, C; Stavrakis, D; Tuominen, I | 1 |
| Hrncir, T; Hudcovic, T; Klimesova, K; Kobayashi, KS; Kopecny, J; Kostovcik, M; Kverka, M; Mrazek, J; Ridl, J; Rossmann, P; Stepankova, R; Tlaskalova-Hogenova, H; Zakostelska, Z | 1 |
| Brennan-Laun, SE; Chakrabarti, A; Ezelle, HJ; Hassel, BA; Long, TM; Polyakova, I; Raufman, JP; Silverman, RH | 1 |
| Knackstedt, RW; Moseley, VR; Sun, S; Wargovich, MJ | 1 |
| Drachenberg, C; Heath, J; Peng, Z; Raufman, JP; Xie, G | 1 |
| Agarwal, C; Agarwal, R; Balaiya, V; Derry, MM; Huber, KM; Jain, AK; Raina, K; Serkova, NJ; Shrotriya, S | 1 |
| Bishnupuri, KS; Ciorba, MA; Foster, L; Kerr, TA; Marinshaw, JM; Newberry, RD; Rao, MS; Stenson, WF; Thaker, AI | 1 |
| Cooma, I; Kawamori, T; Patlolla, JM; Rao, CV; Steele, VE | 1 |
| Allred, CD; Allred, KF; Armstrong, CM; Billimek, AR; Sturino, JM; Weeks, BR | 1 |
| Amin, S; Choi, CI; Desai, D; Janakiram, NB; Mohammed, A; Rao, CV; Ravillah, D; Zhang, Y | 1 |
| Barth, SW; Bousserouel, S; Gossé, F; Le Grandois, J; Marchioni, E; Marescaux, J; Raul, F; Werner, D | 1 |
| Andriana, BB; Hariyani, R; Ishigaki, M; Sato, H; Taketani, A | 1 |
| Athar, M; Katiyar, SK | 1 |
| Kong, AN; Su, ZY; Zhang, C | 1 |
| Esa, NM; Ithnin, H; Saad, N | 1 |
| Davidson, NO; Kennedy, S; Kerr, TA; Luo, J; Matsumoto, H; Nalbantoglu, I; Rubin, DC; Xie, Y | 1 |
| Cai, M; Guo, Q; Hu, R; Li, Z; Wang, Q; Wang, Y; Yang, X; Zhang, F | 1 |
| Bertin, B; Buob, D; Chatelain, D; Colombel, JF; Cortot, A; Desreumaux, P; Dubuquoy, C; Dubuquoy, L; El-Jamal, N; Fumery, M; Langlois, A; Romano, O; Rousseaux, C | 1 |
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| Carroll, RJ; Chapkin, RS; Davidson, LA; Leonardi, T; Lupton, JR; Murphy, ME; Patil, BS; Taddeo, SS; Turner, ND; Vanamala, J; Wang, N | 1 |
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| Lin, DM; MacFarlane, AJ; McEntee, MF; Perry, CA; Stover, PJ | 1 |
| Gandhi, SR; Joshi, S; Koetsier, JL; Kunte, DP; Roy, HK; Tiwari, AK; Wali, RK; Ward, TP | 1 |
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| Clarke, JM; Cosgrove, LJ; Gerber, JP; Head, RJ; Lockett, TJ; Tan, SL; Williams, DB | 1 |
| Barrett, CW; Chaturvedi, R; Fingleton, B; Fischer, MA; Hiebert, SW; Ning, W; Washington, MK; Williams, A; Williams, CS; Wilson, KT | 1 |
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| Mabuchi, R; Miyoshi, N; Nagasawa, T; Ohshima, H; Tanaka, T; Wakabayashi, K; Yasui, Y | 1 |
| Aydos, RD; Higa, RA; Ramalho, RT; Silva, IS; Souza, AS | 1 |
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| Backman, V; Brasky, J; Cornwell, ML; Crawford, SE; De La Cruz, M; Gibson, TP; Gomes, A; Kunte, DP; Mutyal, N; Radosevich, A; Roy, HK; Ruderman, S; Stypula, Y; Tiwari, AK; Wali, RK | 1 |
| Davis, S; Khatiwada, J; Verghese, M; Williams, LL | 1 |
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| Chaudhary, A; Huang, Y; Prabhu, S; Sutaria, D; Wang, J | 1 |
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| Li, Q; Patlolla, JM; Rao, CV; Steele, VE; Zhang, Y | 1 |
| Akira, S; Hara, S; Ishii, T; Ishikawa, Y; Kamei, D; Murakami, M; Sasaki, Y; Uematsu, S | 1 |
| Caprioli, F; Caruso, R; Fantini, MC; Ferrero, S; Franceschilli, L; Franzè, E; MacDonald, TT; Monteleone, G; Monteleone, I; Pallone, F; Rizzo, A; Rotondi, A; Sarra, M; Sileri, P; Stolfi, C | 1 |
| Endlicher, E; Grunwald, N; Lechner, A; Neumann, ID; Obermeier, F; Peters, S; Reber, SO; Rümmele, P | 1 |
| Bird, AR; Clarke, JM; Cobiac, L; Lockett, TJ; Scherer, BL; Topping, DL; Winkler, JG; Young, GP | 1 |
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| Brubaker, PL; El-Zimaity, HM; Trivedi, S; Wiber, SC | 1 |
| Chen, YK; Guan, F; Lee, MJ; Li, G; Lin, Y; Liu, AB; Shih, W; Yang, CS; Yang, Z | 1 |
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| Broaddus, RR; Fischer, SM; Morris, JS; Moussalli, MJ; Parker-Thornburg, J; Peng, Z; Shureiqi, I; Wang, Y; Wu, Y; Yang, XL; Zuo, X | 1 |
| Dubeykovskiy, A; Jin, G; Ramanathan, V; Takaishi, S; Wang, TC; Westphalen, CB; Whelan, A | 1 |
| Hirata, A; Kato, N; Ohata, T; Sanada, Y; Toya, K; Yanaka, N | 1 |
| Abramowitz, J; Birnbaumer, L; Ustyugova, IV; Wu, MX; Zhi, L | 1 |
| Backman, V; DelaCruz, M; Gomes, AJ; Roy, HK; Ruderman, S; Wali, RK | 1 |
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| Alizadeh, AM; Azizian, S; Khaniki, M; Mohaghgheghi, MA; Najafi, F; Sadeghizadeh, M | 1 |
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| Clarke, M; Das, S; Huels, D; Jamieson, T; Jung, A; Neumann, J; Nibbs, RJ; Olson, MF; Samuel, MS; Sansom, OJ; Steele, CW | 1 |
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| Backman, V; DelaCruz, M; Du, H; Kunte, DP; Menon, A; Patel, A; Roy, HK; Stypula, Y; Wali, RK | 1 |
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| Hara, A; Hatano, Y; Hirata, A; Hirose, Y; Kuno, T; Masuda, S; Mori, H; Tanaka, T; Terasaki, M; Tomita, H | 1 |
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| Butler, SM; Jeffery, EH; Jung, SH; Lee, EH; Nho, CW; Pan, CH; Wallig, MA | 1 |
| Ji, P; Ouyang, N; Williams, JL | 1 |
| Ho, CT; Lai, CS; Li, S; Liu, CB; Miyauchi, Y; Pan, MH; Suzawa, M | 1 |
| Kashimoto, N; Tamura, K; Ushijima, M; Watanabe, H | 1 |
| Chitra, P; Manikandan, R; Saiprasad, G; Sudhandiran, G | 1 |
| Baker, A; Colburn, NH; Dodge, LK; Gerard, M; Jiang, H; Toledano, MB; Wei, Q; Young, MR | 1 |
| Inagami, T; Nakano, Y; Takagi, T; Takekoshi, S; Tamura, M | 1 |
| Cobb, S; Given, R; Singh, P; Tarasova, N; Tessarollo, L; Varro, A; Velasco, M; Wood, T | 1 |
| Hasegawa, J; Hosoda, A; Kawasaki, H; Kishimoto, Y; Morisawa, T; Shiota, G | 1 |
| Bird, AR; Coleman, LJ; Landström, EK; McIntosh, GH; Royle, PJ | 1 |
| Bird, RP; McCarthy, B; Raju, J | 1 |
| Hirose, Y; Kawabata, K; Kohno, H; Mori, H; Sugie, S; Tanaka, T; Tsuda, H | 1 |
| Chawan, CB; Rao, DR; Shackelford, L; Verghese, M | 1 |
| Chawan, CB; Rao, DR; Shackelford, L; Verghese, M; Williams, LL | 1 |
| Matsuhashi, N; Nagase, H; Nakagama, H; Nakajima, A; Ochiai, M; Omura, M; Osawa, E; Sekihara, H; Ueno, N; Wada, K; Yoshida, S | 1 |
| Bronson, RT; Drori, S; Edelmann, W; Eng, C; Girnun, GD; Gonzalez, FJ; Kucherlapati, R; Mueller, E; Nambiar, P; Rosenberg, DW; Sarraf, P; Smith, WM; Spiegelman, BM | 1 |
| Biggeri, A; Caderni, G; Clune, Y; Collins, KJ; Dolara, P; Femia, AP; Giannini, A; Luceri, C; Paglierani, M; Salvadori, M | 1 |
| Bissonnette, M; Brasitus, T; Hart, J; Nguyen, L; Sitrin, MD; Stoiber, D; Wali, RK | 1 |
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| Hasegawa, J; Idobe-Fujii, Y; Kishimoto, Y; Marumoto, A; Miura, N; Morisawa, T; Murawaki, Y; Ohishi, T; Sano, A; Shiota, G; Yashima, K | 1 |
| Girnun, G; Guda, K; Lillo, NA; Nambiar, PR; Rosenberg, DW; Whiteley, HE | 1 |
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| Bissonnette, M; Brasitus, T; Cohen, G; Hart, J; Joseph, L; Khare, S; Nguyen, L; Ramaswamy, A; Sitrin, M; Tretiakova, M; Wali, RK; Wang, J; Wen, M | 1 |
| Newmark, HL; Rao, CV; Reddy, BS | 2 |
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| Hata, K; Hirose, Y; Katayama, M; Kuno, T; Mori, H; Qiao, Z; Sakata, K; Yamada, Y; Yoshida, K; Yoshimi, N | 1 |
| Fujisawa, N; Ishimine, S; Kadowaki, T; Kawamori, T; Matsuhashi, N; Nakagama, H; Nakajima, A; Ochiai, M; Osawa, E; Sekihara, H; Wada, K | 1 |
| Bronson, RE; Chung, H; Gay, R; Goldin, B; Han, SN; Mason, JB; Meydani, SN; Smith, DE; Wu, D | 1 |
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| Bronson, R; Chung, H; Gay, R; Goldin, B; Han, SN; Mason, J; Meydani, SN; Smith, DE; Wu, D | 1 |
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| Caderni, G; Dolara, P; Favuzza, A; Femia, AP; Giannini, A; Luceri, C; Salvadori, M | 1 |
| Kawamori, T; Sugimura, T; Uchiya, N; Wakabayashi, K | 1 |
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| Fujihara, H; Kamada, N; Kusuoka, O; Masutani, M; Nakagama, H; Nakamoto, K; Nozaki, T; Sugimura, T; Suzuki, H; Tsutsumi, M; Watanabe, M | 1 |
| Bissonnette, M; Boss, GR; Cerda, S; Cohen, G; Hart, J; Joseph, L; Khare, S; Nimmagadda, K; Sitrin, MD; Stoiber, D; Tretiakova, M; von Lintig, FC; Wali, RK | 1 |
| Fields, AP; Gustafson, WC; Murray, NR | 1 |
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| Beck, F; Bonhomme, C; Chawengsaksophak, K; Chenard, MP; Domon-Dell, C; Duluc, I; Freund, JN; Kedinger, M; Martin, E | 1 |
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| Bennink, M; Browning, JD; Constantinou, A; Guo, JY; Li, X; Lubahn, DB; MacDonald, RS; Rottinghaus, GE | 1 |
| Bonne, A; Fenger, C; Kobaek-Larsen, M; Kristiansen, K; Ritskes-Hoitinga, M; Sørensen, NM; van Zutphen, B | 1 |
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| Exon, J; Nichenametla, S; South, E | 1 |
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| Aniya, Y; Ichiba, T; Inamine, M; Mori, H; Morioka, T; Nabandith, V; Nakayama, T; Suzui, M; Yoshimi, N | 1 |
| Gonzalez, FJ; Harman, FS; Marin, HE; Nicol, CJ; Peters, JM; Ward, JM | 1 |
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| Brandt, K; Christensen, LP; Kobaek-Larsen, M; Ritskes-Hoitinga, J; Vach, W | 1 |
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| Aniya, Y; Ichiba, T; Inamine, M; Morioka, T; Nabandith, V; Nakayama, T; Suzui, M; Yoshimi, N | 1 |
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| Gunning, WT; Lubet, R; Pereira, MA; Tao, LH; Wang, W | 1 |
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| Backman, V; Goldberg, MJ; Kim, YL; Koetsier, JL; Kunte, DP; Liu, Y; Roy, HK; Turzhitsky, V; Wali, RK | 1 |
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| Alexander, J; Knutsen, H; Løberg, EM; Paulsen, JE; Ølstørn, HB | 1 |
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| Patlolla, JM; Rao, CV; Reddy, BS; Simi, B; Wang, SH | 1 |
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| Baldwin, GS; Giraud, AS; Houli, N; Loh, SW; Shulkes, A | 1 |
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| Gallaher, DD; Yang, Y | 1 |
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| Backman, V; Goldberg, MJ; Horwitz, J; Kim, YL; Liu, Y; Roy, HK; Turzhitsky, V; Wali, RK | 1 |
| Asano, N; Hara, A; Hata, K; Hirose, Y; Kuno, T; Mori, H; Osawa, T; Sheng, H; Yamada, Y; Zheng, Q | 1 |
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| Kohno, H; Miyamoto, S; Murakami, A; Ohigashi, H; Sugie, S; Suzuki, R; Tanaka, T | 1 |
| Billin, AN; Gonzalez, FJ; Kennett, MJ; Marin, HE; Peraza, MA; Peters, JM; Ward, JM; Willson, TM | 1 |
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| Kopelovich, L; Liu, X; Ouyang, N; Patlolla, JM; Rao, CV; Reddy, BS; Rigas, B; Simi, B; Steele, VE; Wang, CX | 1 |
| Boateng, J; Chawan, CB; Khatiwada, J; Shackelford, L; Verghese, M; Walker, LT; Williams, DS | 1 |
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| Backman, V; Bissonnette, M; Goldberg, M; Hart, J; Kim, YL; Koetsier, JL; Kunte, DP; Liu, Y; Roy, HK; Wali, RK | 1 |
| Aizu, W; Belinsky, GS; Boes, CC; Doshi, B; Flynn, C; Giardina, C; Godman, CA; Nambiar, PR; Noonan, EJ; Rosenberg, DW | 1 |
| Kitamura, T; Matsuura, M; Mutoh, M; Niho, N; Sato, H; Sugimura, T; Takahashi, M; Wakabayashi, K | 1 |
| Aruoma, OI; Choi, SY; Kim, JS; Kim, MK; Park, JH; Sung, MK | 1 |
| Hosokawa, M; Kohno, H; Miyamoto, S; Miyashita, K; Suzuki, R; Tanaka, T; Yasui, Y | 1 |
| Dragsted, LO; Jacobsen, H; Lindecrona, RH; Meyer, O; Poulsen, M; Ravn-Haren, G | 1 |
| Boateng, J; Chawan, CB; Shackelford, L; Verghese, M; Walker, LT; Williams, D | 1 |
| Hata, K; Hirose, Y; Kohno, H; Miyamoto, S; Sugawara, K; Sugie, S; Sumida, T; Suzuki, R; Tanaka, T; Yasui, Y | 1 |
| Flynn, C; Ilsley, JN; Montrose, DC; Nakanishi, M; Rosenberg, DW; Swank, DL | 1 |
| Daly, KT; Francke-Carroll, S; Magnuson, BA; Malik, M; Tracy, AC; Wang, T | 1 |
| Huang, MT; Newmark, HL; Reddy, BS | 1 |
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| Fujimoto, K; Fujise, T; Iwakiri, R; Kakimoto, T; Ootani, A; Sakata, Y; Shiraishi, R; Tsunada, S; Wu, B | 1 |
| Hao, X; Paul, S; Reddy, BS; Rimando, AM; Simi, B; Suh, N; Xiao, H | 1 |
| Chan, HY; Chen, MH; Lin, SY; Shen, FH; Wang, YJ; Yu, CK | 1 |
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| Amaral, EG; Fagundes, DJ; Inouye, CM; Marks, G | 1 |
| Amaral, EG; Aydos, RD; Fagundes, DJ; Marks, G; Pontes, ER; Rossini, A; Takita, LC; Ynouye, CM | 1 |
| Asiamah, D; Boateng, J; Chawan, CB; DeBruce, M; Grant, L; Guyton, M; Henderson, F; Johnson, A; Jones, J; Khatiwada, J; Ogutu, S; Shackelford, L; Verghese, M; Walker, LT; Washington, S; Williams, DS | 1 |
| Chaabi, M; Gossé, F; Lamy, V; Lobstein, A; Raul, F; Roussi, S; Schall, N | 1 |
| Kohno, H; Miyamoto, S; Suzuki, R; Tanaka, T; Wakabayashi, K; Yasui, Y | 1 |
| Miyamoto, S; Sugie, S; Suzuki, R; Tanaka, T; Yasui, Y | 1 |
| Hirschelman, WH; Ito, A; Kinghorn, AD; Mehta, RG; Moriarty, RM; Murillo, G; Pezzuto, JM | 1 |
| Hayashi, K; Kohno, H; Miyamoto, S; Shin-Ichiroh, Y; Sugie, S; Suzuki, R; Takashima, S; Tanaka, T | 1 |
| Andersson, D; Cheng, Y; Duan, RD | 1 |
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| Issa, AY; Muga, SJ; Nitcheva, D; Smith, T; Volate, SR; Wargovich, MJ | 1 |
| Backman, V; Goldberg, MJ; Hart, J; Kim, Y; Koetsier, JL; Kunte, DP; Liu, Y; Roy, HK; Wali, RK | 1 |
| Balik, E; Belizon, A; Ciau, N; Jain, S; Kirman, I; Remotti, H; Whelan, RL | 1 |
| Baran, AA; Bombonati, A; Hyslop, TM; Li, P; Palazzo, JP; Pitari, GM; Schulz, S; Siracusa, LD; Waldman, SA; Xu, Y | 1 |
| Carroll, RE; Fernandez, PA; Hagos, GK; Kouznetsova, T; Li, Q; Swanson, SM; Thatcher, GR; Toader, V | 1 |
| Becker, C; Neufert, C; Neurath, MF | 1 |
| Choi, CI; Guruswamy, S; Rao, CV; Steele, VE; Swamy, MV | 1 |
| Crary, K; Dong, M; Guda, K; Jung, Y; Marino, JN; Rosenberg, DW | 1 |
| Aviello, G; Borrelli, F; Capasso, F; Capasso, R; Di Marzo, V; Izzo, AA; Lutz, B; Marsicano, G; Nigam, S; Orlando, P; Petrosino, S | 1 |
| Hirohashi, S; Honda, K; Ono, M; Satow, R; Shitashige, M; Yamada, T | 1 |
| Badger, TM; Hennings, LJ; Simmen, FA; Xiao, R | 1 |
| Beppu, F; Hosokawa, M; Kohno, H; Miyamoto, S; Miyashita, K; Suzuki, R; Tanaka, T; Yasui, Y | 1 |
| Brown, IL; Esterman, A; Hu, Y; Le Leu, RK; Young, GP | 1 |
| Fox, JG; Nagamine, CM; Rogers, AB; Schauer, DB | 1 |
| Christudoss, P; Fleming, JJ; Mathew, G; Pulimood, AB; Selvakumar, R | 1 |
| Cooma, I; Janakiram, NB; Mohammed, A; Rao, CV; Steele, VE | 1 |
| Fujii, C; Kagaya, T; Kaneko, S; Kitamura, K; Kondo, T; Mukaida, N; Oshima, M; Popivanova, BK; Wu, Y | 1 |
| Cenesiz, S; Devrim, AK; Kamber, U; Sozmen, M | 1 |
| Calcagno, SR; Colon, M; Fields, AP; Kreinest, PA; Li, S; Murray, NR; Thompson, EA | 1 |
| Belobrajdic, D; Hu, Y; Le Leu, RK; Young, GP | 1 |
| Blumberg, RS; Fujisawa, N; Fujisawa, T; Ikeda, I; Kadowaki, T; Kubota, N; Kudo, C; Nakagama, H; Nakajima, A; Nakajima, N; Takahashi, H; Terauchi, Y; Tomimoto, A; Wada, K; Yonemitsu, K | 1 |
| Indranie, C; Jagan, P; Janakiram, NB; Malisetty, SV; Rao, CV; Steele, VE | 1 |
| Aluri, L; Bissonnette, M; Cerda, S; Chumsangsri, A; Cohen, EE; Delgado, J; Dougherty, U; Fichera, A; Hart, J; Jagadeeswaran, S; Joseph, L; Little, N; Mustafi, R; Sehdev, A; Tretiakova, M; Yuan, W | 1 |
| Doi, K; Fukushima, S; Hagihara, A; Wanibuchi, H; Wei, M; Yunoki, T | 1 |
| Albert, PS; Barrett, KG; Bennink, MR; Bobe, G; Colburn, NH; Lanza, E; Mentor-Marcel, RA; Saffiotti, U; Young, MR | 1 |
| Bissonnette, M; Cerda, S; Cohen, G; Dougherty, U; Fichera, A; Holgren, C; Jagadeeswaran, S; Joseph, L; Khare, S; Li, YC; Moore, C; Mustafi, R; Samarel, A; Tretiakova, M; Wali, R; Wang, J; Yuan, W | 1 |
| Cheng, K; Drachenberg, C; Khurana, S; Raufman, JP; Samimi, R; Shah, N; Shant, J; Wess, J; Xie, G | 1 |
| Mori, H; Nicolais, M; Reddy, BS | 1 |
| Aust, JB; Moyer, MP | 1 |
| Hartman, PE; Owens, RA | 1 |
| Day, DW; Devitt, P; Jenkins, SA; Mooney, B; Shields, R; Taylor, I | 1 |
| Lijinsky, W; Reuber, MD; Saavedra, JE | 1 |
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| Furuya, K; Lowenfels, A; Reddy, BS | 1 |
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| Izbicki, JR; Izbicki, W; Kamran, D; Schmitz, R | 1 |
| Bristol, JB; Davies, PW; Rainey, JB; Williamson, RC | 1 |
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| Davies, PW; Rainey, JB; Williamson, RC | 2 |
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| Maeda, M; Rainey, JB; Williams, C; Williamson, RC | 1 |
| Cooke, T; Goeting, N; Inman, C; Kirkham, N; Stainthorp, DH; Taylor, I | 1 |
| Hioki, K; Hiramatsu, Y; Saito, K; Takada, H; Yamamoto, M; Yamamura, M | 1 |
| Shamsuddin, AM | 1 |
| Shamsuddin, AK; Trump, BF | 1 |
| Hiramatsu, Y; Hirooka, T; Takada, H; Yamamoto, M | 1 |
| Bristol, JB; Davies, PW; Wells, M; Williamson, RC | 1 |
| Mooney, B; Taylor, I | 1 |
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| Baba, M; Iishi, H; Nakaizumi, A; Tatsuta, M; Uehara, H; Yano, H | 1 |
| Bird, RP; Brière, KM; Kuesel, AC; Smith, IC | 1 |
| Alabaster, O; Belinsky, SA; Shivapurkar, N; Tang, Z; Wolf, DC | 1 |
| Bird, RP; Lafave, LM | 1 |
| Holt, PR; Liu, T; Mokuolu, AO; Rao, CV; Reddy, BS | 1 |
| Magnuson, BA; Moyana, TN; Raju, RV; Sharma, RK | 1 |
| Bissonnette, M; Brasitus, TA; Earnest, DL; Frawley, BP; Hartmann, S; Khare, S; Roy, HK; Scaglione-Sewell, BA; Sitrin, MD; Wali, RK | 1 |
| Barzilai, M; Cohen, I; Reshef, R; Rotter, V; Shasha, SM; Shkolnik, T; Tendler, Y | 1 |
| Hara, A; Hirose, Y; Kawamori, T; Mori, H; Satoh, K; Tamai, Y; Tanaka, T; Torihara, M; Yamahara, J | 1 |
| Bird, RP | 3 |
| Bissonnette, M; Brasitus, TA; Hart, J; Khare, S; Sitrin, MD; Wali, RK | 1 |
| Baba, M; Iishi, H; Nakaizumi, A; Tatsuta, M; Uehara, H; Yamamoto, R | 1 |
| Baba, M; Iishi, H; Iseki, K; Nakaizumi, A; Tatsuta, M; Uehara, H | 1 |
| Fujimaki, M; Kobashi, K; Murai, K; Ohkami, H; Shimizu, T; Tazawa, K; Yamashita, I | 1 |
| Kuratko, CN; Pence, BC | 1 |
| Hara, A; Hirose, Y; Kawamori, T; Mori, H; Nakamura, Y; Ohnishi, M; Satoh, K; Tanaka, T | 1 |
| Hamid, R; Kelloff, GJ; Rao, CV; Reddy, BS; Rivenson, A; Simi, B; Steele, V; Zang, E | 1 |
| Calderopoli, R; Contegiacomo, A; D'Adamo, G; D'Agostino, L; Daniele, B; Mazzacca, G; Pignata, S; Pizzi, C; Squame, G; Tritto, G | 1 |
| Biggeri, A; Caderni, G; Dolara, P; Giannini, A; Lancioni, L; Luceri, C | 1 |
| Dunn, DM; Landers, M; Pence, BC; Wargovich, MJ; Zhao, C | 1 |
| Baba, M; Iishi, H; Nakaizumi, A; Tatsuta, M; Uehara, H | 1 |
| Amin, S; Desai, D; Rao, CV; Reddy, BS; Rivenson, A; Simi, B | 1 |
| Bissonnette, M; Brasitus, TA; Earnest, D; Frawley, BP; Niedziela, SM; Roy, HK; Wali, RK | 1 |
| Kulkarni, N; Reddy, BS | 1 |
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| Chen, CD; Harris, C; Velasco, M; Wargovich, MJ; Yang, E | 1 |
| Alabaster, O; Frost, A; Shivapurkar, N; Tang, Z | 1 |
| Allan, C; Brasitus, TA; Rigas, B; Tsioulias, GJ; Wali, RK | 1 |
| Hara, A; Kawamori, T; Mori, H; Tanaka, T; Yamahara, J | 1 |
| Kelloff, G; Rao, CV; Reddy, BS; Rivenson, A; Simi, B; Steele, V; Zang, E | 1 |
| Kawamori, T; Kojima, T; Mori, H; Tanaka, T | 1 |
| Cosenza, V; D'Argenio, G; D'Armiento, FP; De Ritis, F; Delle Cave, M; Iovino, P; Mazzacca, G; Sorrentini, I | 1 |
| Esumi, H; Minamoto, T; Onda, M; Yamashita, N | 1 |
| Bhattacharyya, AK; Bissonette, M; Brasitus, TA; Earnest, DL; Holubec, H; Jolley, CS; Khare, S; Roy, H; Wali, RK | 1 |
| Conney, AH; Huang, MT; Lou, YR; Ma, W; Newmark, HL; Reuhl, KR | 1 |
| Bianco, AR; Calderopoli, R; D'Adamo, G; D'Agostino, L; Daniele, B; Esposito, G; Mazzacca, G; Pignata, S; Pizzi, C; Tritto, G | 1 |
| Kelloff, G; Kulkarni, N; Reddy, BS; Singh, J | 1 |
| Bird, RP; Magnuson, BA; Shirtliff, N | 1 |
| Kawamori, T; Kojima, T; Mori, H; Ohnishi, M; Suzui, M; Tanaka, T | 1 |
| Cheyer, C; O'Riordan, MA; Pretlow, TP | 1 |
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| Alabaster, O; Ferreira, A; Garett, C; Nasim, S; Shivapurkar, N; Tang, Z | 1 |
| Corpet, DE; Goubet, I; Pirot, V | 1 |
| Barnes, LH; Kelloff, GV; Pereira, MA; Rassman, VL; Steele, VE | 1 |
| el-Omar, E; Hillan, KJ; McColl, KE; McGregor, JR; O'Dwyer, PJ; Penman, ID | 1 |
| Bird, RP; Stopera, SA | 2 |
| Hubens, A; Hubens, G; Totté, E; Van Marck, E; Verhulst, A | 1 |
| Kelloff, G; Rao, CV; Reddy, BS; Rivenson, A | 2 |
| Kojima, T; Mori, H; Suzui, M; Tanaka, T | 1 |
| Amin, S; Desai, D; Kulkarni, N; Rao, CV; Reddy, BS; Simi, B | 1 |
| Ghose, T; Reddy, BS; Rijhsinghani, K | 1 |
| Bird, RP; Carr, I; Magnuson, BA | 1 |
| Bruce, WR; Gallinger, S; Hay, K; Medline, A; Shpitz, B; Stern, HS; Vivona, AA; Ward, MA | 1 |
| Bird, RP; Magnuson, BA | 1 |
| Jacobsen, NO; Overvad, K; Thorling, EB | 1 |
| Kelloff, G; Reddy, BS; Singh, J | 1 |
| Archer, MC; Bruce, WR; Chan, CC; Minkin, S; Stamp, D; Zhang, XM | 1 |
| Archer, MC; Bruce, WR; Medline, A; Stamp, D; Zhang, XM | 1 |
| Katiwalla, M; Kelloff, GJ; Rao, CV; Reddy, BS; Rivenson, A | 1 |
| Holt, PR; Kumar, SP; Lipkin, M; Reddy, BS; Steinbach, G | 1 |
| O'Riordan, MA; Pretlow, TG; Pretlow, TP; Spancake, KM | 1 |
| Adham, NF; Ament, ME; Costea, NV; Heng, MC; Heng, MK; Song, MK | 1 |
| Reddy, BS; Singh, J | 1 |
| Gustafson-Svärd, C; Hallböök, O; Lilja, I; Sjödahl, R | 1 |
| Fukutake, M; Ishida, K; Sugimura, T; Takahashi, M; Wakabayashi, K; Yokota, S | 1 |
| Hara, A; Kawamori, T; Makita, H; Mori, H; Ohnishi, M; Satoh, K; Tanaka, T | 1 |
| Alexander, J; Paulsen, JE; Steffensen, IL | 1 |
| Iwamoto, Y; Kendall, CW; Rao, AV; Sugano, M; Torzsas, TL | 1 |
| Cassand, P; Corpet, DE | 1 |
| DuBois, RN; Entingh, AJ; Radhika, A; Reddy, BS | 1 |
| Alabaster, O; Frost, A; Shivapurkar, N; Tang, ZC | 2 |
| Aliaga, C; Patel, N; Rao, CV; Reddy, BS; Simi, B | 1 |
| Hirose, Y; Kawamori, T; Mori, H; Ohnishi, M; Tanaka, T | 1 |
| Barnes, LH; Kelloff, GV; Lubet, RA; Pereira, MA; Steele, VE | 1 |
| Alabaster, O; Shivapurkar, N; Tang, Z | 2 |
| Bird, RP; Good, CK; Lasko, CM; Yao, K | 1 |
| Kawamori, T; Komaki, C; Mori, H; Moriwaki, H; Muto, Y; Okuno, M; Onogi, N; Tanaka, T | 2 |
| Barnes, LH; Eto, I; Grubbs, CJ; Juliana, M; Kelloff, GJ; Li, H; Lubet, RA; Olson, GR; Pereira, MA; Steele, VE; Whitaker, LM | 1 |
| Aquino, B; Bissonnette, M; Brasitus, TA; Khare, S; Niedziela, S; Sitrin, M; Wali, RK | 1 |
| Cameron, IL; Hardman, WE | 1 |
| Aiolli, S; Caderni, G; Dolara, P; Lancioni, L; Luceri, C; Mastrandrea, V; Morozzi, G; Scardazza, F | 1 |
| Alpern, HD; Jenkins, PL; Krause, JA; Parfitt, MM; Stragand, JJ; Tangel, C; Weaver, GA | 1 |
| Hara, A; Hirose, Y; Maeda, M; Makita, H; Mori, H; Satoh, K; Tanaka, T; Toriyama, HB; Tsuda, H; Yang, M | 1 |
| Bird, RP; Shirtliff, N | 1 |
| Rao, CV; Reddy, BS; Seibert, K | 1 |
| Bird, RP; Latta, M; Yao, K | 1 |
| Badger, TM; Hakkak, R; Korourian, S; Ronis, MJ | 1 |
| Bruce, WR; Medline, A; Tran, TT | 1 |
| Hamid, R; Reddy, BS; Singh, J | 3 |
| Kelloff, GJ; Lubet, R; Rao, CV; Reddy, BS; Samaha, H; Steele, VE; Wang, CX | 1 |
| Challa, A; Chawan, CB; Rao, DR; Shackelford, L | 1 |
| Chapkin, RS; Ha, SD; Lupton, JR; Maciorowski, KG; Ricke, SC; Shermer, CL; Turner, ND | 1 |
| El-Bayoumy, K; Pittman, B; Rao, CV; Reddy, BS; Rivenson, A; Upadhyaya, P | 1 |
| Corpet, DE; Jacquinet, C; Peiffer, G; Taché, S | 1 |
| Fukuda, K; Ohata, T; Sugimura, T; Takahashi, M; Wakabayashi, K | 1 |
| Kelloff, GJ; Rao, CV; Reddy, BS; Samaha, HS; Steele, V | 1 |
| Chatelin-Pirot, V; Corpet, DE | 1 |
| Koratkar, R; Rao, AV | 1 |
| Dorado, I; Navarro, E; Valencia, ME; Wyatt, CJ | 1 |
| Chen, CD; Gray, K; Jimenez, A; Kelloff, GJ; Price, R; Steele, VE; Stephens, LC; Velasco, M; Wargovich, MJ | 1 |
| Hara, A; Kakumoto, M; Kawabata, K; Makita, H; Mori, H; Ogawa, H; Satoh, K; Sumida, T; Tanaka, T | 1 |
| Hirose, Y; Kawabata, K; Mori, H; Suzui, M; Tanaka, T; Yoshimi, N | 1 |
| Ahnen, DJ; Erdman, SH; Gerner, EW; Hixson, LJ; Wu, HD | 1 |
| Ahnen, DJ; Alberts, DS; Bogert, C; Brendel, K; Burt, RW; Ellsworth, L; Finn, T; Gross, PH; Guillen, JM; Hixson, LJ; Li, H; Pamukcu, R; Paranka, NS; Piazza, GA; Ritchie, J; Sperl, G | 1 |
| Fukuda, K; Fukutake, M; Isoi, T; Sato, H; Sugimura, T; Takahashi, M; Wakabayashi, K; Yazawa, K | 1 |
| Li, K; Pereira, MA; Tao, L | 1 |
| Asamoto, M; Baba-Toriyama, H; Kakizoe, T; Kim, DJ; Krutovskikh, V; Masuda, M; Moore, MA; Nakamura, J; Nishino, H; Ota, T; Sekine, K; Sugimoto, H; Takasuka, N; Tsuda, H; Watanabe, E | 1 |
| Kelloff, G; Lubet, R; Rao, CV; Reddy, BS; Simi, B; Steele, V; Wang, CX | 1 |
| el-Bayoumy, K; Hamid, R; Rao, CV; Reddy, BS; Samaha, HS | 1 |
| Chapkin, RS; Jiang, YH; Lupton, JR | 1 |
| Arimochi, H; Kataoka, K; Kinouchi, T; Kuwahara, T; Ohnishi, Y | 1 |
| Chapkin, RS; Lupton, JR; Taddeo, SS; Turner, ND; Zoran, DL | 1 |
| Kawabata, K; Matsunaga, K; Mori, H; Morishita, Y; Sugie, S; Tanaka, T; Yoshimi, N | 1 |
| Hara, A; Kakumoto, M; Kawabata, K; Koshimizu, K; Makita, H; Matsunaga, K; Mori, H; Murakami, A; Ohigashi, H; Satoh, K; Tanaka, T | 1 |
| Kelloff, GJ; Kramer, PM; Lubet, RA; Olson, G; Pereira, MA; Steele, VE; Zheng, Y | 1 |
| Hara, A; Kakumoto, M; Kawabata, K; Koshimizu, K; Kuki, W; Makita, H; Mori, H; Murakami, A; Ohigashi, H; Satoh, K; Takahashi, Y; Tanaka, T; Yonei, H | 1 |
| Ganthavorn, C; Hughes, JS; Wilson-Sanders, S | 1 |
| Aliaga, C; Balentine, DA; Boone, CW; Kelloff, GJ; Pittman, B; Reinhardt, J; Rivenson, A; Steele, VE; Weisburger, JH; Zang, E | 1 |
| Fukuda, K; Sugimura, T; Takahashi, M; Wakabayashi, K | 1 |
| Hara, A; Kawabata, K; Matsunaga, K; Mori, H; Yamada, Y; Yoshimi, N | 1 |
| Ahnen, D; Driggers, L; Maltzman, T; Stephens, J; Whittington, J | 1 |
| Kawamori, T; Rao, CV; Reddy, BS; Seibert, K | 1 |
| Brockman, J; DuBois, RN; Gupta, R; Krakow, SL; Lazar, MA; Reddy, BS | 1 |
| Aliaga, C; Braley, J; Pittman, B; Reinhardt, J; Rivenson, A; Weisburger, JH; Zang, E | 1 |
| Chang, WL; Chapkin, RS; Lupton, JR | 1 |
| Aymond, CM; Chapkin, RS; Davidson, LA; Jiang, YH; Lupton, JR; Turner, ND | 1 |
| Coutts, JT; Lievense, LC; Rowland, IR; Rumney, CJ | 1 |
| Kelloff, GJ; Kramer, PM; Li, H; Lubet, RA; Pereira, MA; Steele, VE | 2 |
| Hori, T; Matsumoto, K; Morotomi, M; Sakaitani, Y; Sato, M | 1 |
| Exon, JH; Hendrix, K; Magnuson, BA; South, EH | 3 |
| Alexander, J; Paulsen, JE; Stamm, T | 1 |
| Baba-Toriyama, H; Iigo, M; Kakizoe, T; Kuhara, T; Moore, MA; Murakoshi, M; Nishino, H; Satomi, Y; Sekine, K; Tsuda, H; Ushida, Y | 1 |
| El-Bayoumy, K; Ji, BY; Kawamori, T; Rao, CV; Reddy, BS; Rodriguez, JG | 1 |
| Bak, AW; Calignano, A; Cirino, G; Del Soldato, P; Li, P; McKnight, W; Wallace, JL | 1 |
| Caderni, G; Dolara, P; Lancioni, L; Luceri, C; Tessitore, L | 1 |
| Binasco, V; Caderni, G; Premoselli, F; Sesca, E; Tessitore, L | 1 |
| Chapkin, RS; Lupton, JR; Wu, G; Zhang, J | 1 |
| Amagaya, S; Fukuda, K; Fukutake, M; Iizuka, A; Kawamura, H; Komatsu, Y; Yokota, S | 1 |
| Delker, DA; Papanikolaou, A; Rosenberg, DW; Wang, QS | 1 |
| Baijal, PK; Bird, RP; Fitzpatrick, DW | 1 |
| Asamoto, M; Baba-Toriyama, H; Kakizoe, T; Kim, DJ; Kuhara, T; Moore, MA; Nakamura, J; Nishino, H; Sekine, K; Takasuka, N; Tsuda, H; Ushida, Y | 1 |
| Adam, J; Bird, RP; Good, CK; Lasko, CM | 2 |
| Davies, MJ; Rumsby, PC | 1 |
| Bernheim, J; Bomstein, Y; Buklan, G; Kariv, N; Shalev, M; Shpitz, B | 1 |
| Bissonnette, M; Bolt, MJ; Brasitus, TA; Mailloux, RJ; Rasenick, MM; Sitrin, MD; Skarosi, S; Wali, RK | 1 |
| Bennink, MR; Bourquin, LD; Kavas, FA; Thiagarajan, DG | 1 |
| Fukaura, Y; Narisawa, T; Sekiguchi, H; Terada, K | 1 |
| Fukuda, K; Fukutake, M; Isoi, T; Mamiya, S; Nakatsugi, S; Ohta, T; Sato, H; Sugimura, T; Takahashi, M; Taniguchi, Y; Wakabayashi, K | 1 |
| Papanikolaou, A; Rosenberg, DW; Sabourin, CL; Wang, QS | 1 |
| Hirabayashi, N; Ikegami, T; Kano, M; Matsuzaki, Y; Shoda, J; Tanaka, N | 1 |
| Brasic, GM; Gould, MN; Grubbs, CJ; Haag, JD; Kelloff, GJ; Lubet, RA; Newton, MA; Shepel, LA | 1 |
| Corpet, DE; Parnaud, G; Peiffer, G; Taché, S | 1 |
| Aramandla, R; Beauchamp, RD; DuBois, RN; Grogan, L; Hawk, E; Kirsch, IR; Lubet, RA; Pereira, MA; Shao, J; Sheng, H; Washington, MK | 1 |
| Kelloff, GJ; Kramer, PM; Lubet, RA; Pereira, MA; Steele, VE; Zheng, Y | 1 |
| Conran, P; Hawk, EE; Kelloff, GJ; Kramer, PM; Li, H; Lubet, RA; Pereira, MA; Schut, HA; Steele, VE | 1 |
| Indranie, C; Rao, CV; Reddy, BS; Sanders, ME; Simi, B | 1 |
| Ben-Hur, H; Berman, V; Gurevich, P; Guy, M; Moriel, E; Plonsky, E; Rozenberg, V; Sandler, B; Tendler, Y; Zusman, I; Zusman, R | 1 |
| Hamid, R; Kawamori, T; Rao, CV; Reddy, BS | 1 |
| Bolt, AB; Goldsby, JS; Papanikolaou, A; Rosenberg, DW; Walsh, A; Wang, QS | 1 |
| Delker, DA; Papanikolaou, A; Rosenberg, DW; Wang, QS; Whiteley, HE | 1 |
| Baijal, PK; Bird, RP; Clow, EP; Fitzpatrick, DW | 1 |
| Iishi, H; Iseki, K; Ishiguro, S; Sakai, N; Tatsuta, M; Uehara, H; Yano, H | 1 |
| Calvert, RJ; Diwan, BA; Shiao, YH; Walchle, C | 1 |
| Chapkin, RS; Davidson, LA; Jiang, YH; Lupton, JR | 1 |
| Corpet, DE; Parnaud, G | 1 |
| Adlercreutz, H; Bowey, EA; Davies, MJ; Rowland, IR; Rumsby, PC | 1 |
| Fujii, K; Hara, A; Matsunaga, K; Mori, H; Shimizu, M; Yamada, Y; Yoshimi, N | 1 |
| Kawamori, T; Kelloff, GJ; Lubet, RA; Rao, CV; Reddy, BS; Steele, VE | 1 |
| Kawamori, T; Kelloff, G; Lubet, R; Rao, CV; Reddy, BS; Steele, V | 1 |
| Azuma, N; Iwami, K; Kanamoto, R; Kanaya, M | 1 |
| Ikeda, M; Matsumoto, K; Moriyama, R; Morotomi, M; Sakaitani, Y; Satou, M; Takagi, A; Takahashi, T; Uchida, K; Watanabe, N | 1 |
| Arimochi, H; Kataoka, K; Kuwahara, T; Misawa, N; Nakayama, H; Ohnishi, Y | 1 |
| Arimochi, H; Chewonarin, T; Kataoka, K; Kinouchi, T; Kuwahara, T; Ohnishi, Y; Vinitketkumnuen, U | 1 |
| Agarwal, B; Bhendwal, S; Holt, PR; Ramey, WR; Rao, CV; Reddy, BS; Shirin, H | 1 |
| Kawamori, T; Kondo, K; Maruyama, T; Nakatsugi, S; Narumiya, S; Ohta, T; Ohuchida, S; Sugimura, T; Ushikubi, F; Wakabayashi, K; Watanabe, K; Yamamoto, H | 1 |
| Hara, A; Kawabata, K; Kuno, T; Matsunaga, K; Mori, H; Murai, H; Murakami, T; Okada, T; Shimizu, M; Sugie, S; Tanaka, T; Yamada, Y; Yamamoto, T; Yoshimi, N | 1 |
| Boggio, M; Borrelli, F; Capasso, F; Izzo, AA; Mascolo, N; Massa, B; Mereto, E; Orsi, P; Sini, D | 2 |
| Bissonnette, M; Brasitus, TA; Dolan, ME; Hart, J; Moschel, RC; Mustafi, R; Nguyen, L; Skarosi, S; Wali, RK; Zhang, Y | 1 |
| Hanausek, M; Mori, H; Slaga, TJ; Szemraj, J; Walaszek, Z; Yoshimi, N | 1 |
| Aadland, E; Fagerhol, MK; Kristinsson, J; Løberg, EM; Nygaard, K; Paulsen, JE; Røseth, AG; Sundset, A | 1 |
| Alvarez, M; Bartolí, R; Cabré, E; Castellà, E; Fernández-Bañares, F; Gassull, MA; Mañé, J; Navarro, E; Pastor, C | 1 |
| DuBois, RN; Radhika, A; Shattuck-Brandt, RL; Varilek, GW; Washington, MK; Yang, F | 1 |
| Bolt, A; Mulherkar, R; Papanikolaou, A; Rosenberg, DW; Wang, QS | 1 |
| Azuma, N; Iwami, K; Iwasaki, H; Kanamoto, R; Suda, H | 1 |
| Hirose, Y; Kelloff, G; Lubet, R; Paulson, S; Rao, CV; Reddy, BS; Seibert, K; Steele, V | 1 |
| Kawamori, T; Nakatsugi, S; Ohta, T; Sugimura, T; Takahashi, M; Wakabayashi, K; Watanabe, K | 1 |
| Bollito, E; Caderni, G; Tessitore, L | 1 |
| Given, R; Singh, P; Varro, A; Velasco, M; Wang, TC; Wargovich, M | 1 |
| Hirose, Y; Kelloff, GJ; Lubet, RA; Rao, CV; Reddy, BS; Steele, VE | 1 |
| Campart, GB; Carrozzino, R; Ghia, M; Martelli, A; Mattioli, F; Mereto, E; Orsi, P; Puglia, CP | 1 |
| Han, BS; Iigo, M; Kuhara, T; Moore, MA; Sekine, K; Takasuka, N; Tsuda, H; Ushida, Y | 1 |
| Kral, JG; Scholes, J; Stein, DE; Weber, RV | 1 |
| Baba, M; Iishi, H; Nakaizumi, A; Sakai, N; Tatsuta, M; Uehara, H; Yano, H | 1 |
| Nakatsugi, S; Sugimura, T; Takahashi, M; Wakabayashi, K | 1 |
| Kawamori, T; Kondo, K; Maruyama, T; Nakatsugi, S; Narumiya, S; Ohta, T; Ohuchida, S; Sugimura, T; Wakabayashi, K; Watanabe, K; Yamamoto, H | 1 |
| Johnson, LK; Kim, YS; MacGregor, DJ; Sleisenger, MH | 1 |
| Corpet, DE; Delverdier, M; Parnaud, G; Peiffer, G; Taché, S | 1 |
| Azuma, N; Iwami, K; Kanamoto, R; Machida, K; Saeki, T | 1 |
| Kawamori, T; Mutoh, M; Sugimura, T; Takahashi, M; Wakabayashi, K | 1 |
| Given, R; Singh, P; Varro, A; Velasco, M; Wang, TC | 1 |
| Bennink, MR; Chee, KM; Miyagi, Y; Om, AS | 1 |
| Amagaya, S; Fukuda, K; Fukutake, M; Iijima, O; Ishige, A; Ishikawa, H; Komatsu, Y; Kubo, M; Miura, N; Okada, M; Sasaki, H; Wakabayashi, K; Yamamoto, M | 1 |
| Hara, A; Kawabata, K; Matsunaga, K; Mori, H; Shimizu, M; Tanaka, T; Yamada, Y; Yamamoto, T | 1 |
| Hara, A; Hirose, Y; Kawabata, K; Matsunaga, K; Mori, H; Shimizu, M; Yamada, Y; Yoshimi, N | 1 |
| Brown, RE; Carroll, RJ; Chang, WC; Chapkin, RS; Davidson, LA; Lupton, JR; Morris, JS; Turner, ND; Wang, N | 1 |
| Jenab, M; Thompson, LU | 1 |
| Papanikolaou, A; Papanikolaou, D; Rosenberg, DW; Wang, QS; Whiteley, HE | 1 |
| Dong, M; Guda, K; Papanikolaou, A; Rosenberg, DW; Wang, QS | 1 |
| Battey, JF; Benya, RV; Carroll, RE; Matkowskyj, KA; Tretiakova, MS | 1 |
| Nambiar, PR; Papanikolaou, A; Rosenberg, DW; Wang, QS | 1 |
| Azuma, Y; Kagami, S; Kohno, H; Murakami, M; Ogawa, H; Shimada, R; Sumida, T; Tanaka, T | 1 |
| Fan, K; Kelloff, GJ; Lamprecht, SA; Leung, D; Lipkin, M; Liu, Y; Newmark, H; Shinozaki, H; Steele, VE; Yang, K | 1 |
| Caderni, G; De Filippo, C; Dolara, P; Gambacciani, L; Giannini, A; Luceri, C; Salvadori, M | 1 |
| Katoh, O; Masaoka, Y; Watanabe, H | 1 |
| Bissonnette, M; Boss, GR; Brasitus, TA; Hart, J; Khare, S; Nguyen, L; Skarosi, S; Varki, N; von Lintig, FC; Wali, RK; Zhang, Y | 1 |
| Cohen, LA; Cooma, I; Hirose, Y; Rao, CV; Reddy, BS; Simi, B | 1 |
| Alexander, J; Fulland, RC; Paulsen, JE | 1 |
| Baba, M; Iishi, H; Ishiguro, S; Narahara, H; Sakai, N; Tatsuta, M; Uedo, N; Yano, H | 1 |
| Baines, AT; Basye, JL; Bhattacharyya, AK; Clark, LC; Cui, H; Earnest, DL; Holubec, H; Nelson, MA; Roe, D; Shriver, B; Spallholz, J; Thorne, P | 1 |
| Le Leu, RK; McIntosh, GH; Young, GP | 2 |
| Berreur, M; Bornet, F; Champ, M; Meflah, K; Menanteau, J; Patry, Y; Perrin, P; Pierre, F; Pradal, G | 1 |
| Chung, FL; Conaway, CC; Rao, CV; Reddy, BS | 1 |
| Corpet, DE; Millet, AS; Peiffer, G; Taché, S | 1 |
| Iijima, H; Kobayashi, H; Matsunaga, K | 1 |
| Kagami, S; Kohno, H; Maeda, M; Miyake, M; Murakami, M; Tanaka, T; Wada, K | 1 |
| Hara, A; Katayama, M; Kuno, T; Matsunaga, K; Mori, H; Qiao, Z; Yamada, Y; Yamahara, J; Yoshimi, N | 1 |
| McIntosh, GH; Pointing, G; Royle, PJ | 1 |
| Kawamori, T; Nakatsugi, S; Wakabayashi, K; Watanabe, K | 1 |
| Iigo, M; Sekine, K; Takasuka, N; Toriyama-Baba, H; Tsuda, H | 1 |
| Honjo, S; Kohno, H; Miyake, M; Tanaka, T; Tanino, M; Tsukio, Y; Wada, K | 1 |
| Fields, AP; Gatalica, Z; Gökmen-Polar, Y; Murray, NR; Velasco, MA | 1 |
| Hirose, Y; Indranie, C; Rao, CV; Reddy, BS | 1 |
| Arimochi, H; Chiampanichayakul, S; Kataoka, K; Kuwahara, T; Nakayama, H; Ohnishi, Y; Thumvijit, S; Vinitketkumnuen, U | 1 |
| Hosokawa, M; Kohno, H; Murakami, A; Okumura, A; Takashima, S; Tanaka, T; Yoshitani, S | 1 |
| Badger, TM; Hakkak, R; Johnston, JM; Korourian, S; Ronis, MJ | 2 |
| Ahn, B; Choi, KS; Kang, JS; Kim, DJ; Kim, KS; Kim, ND; Park, KH; Surh, YJ | 1 |
| Cooma, I; El-Bayoumy, K; Rao, CV; Reddy, BS; Rodriguez, JG; Simi, B; Wang, CQ | 1 |
| Anton, R; Gossé, F; Lobstein, A; Metz, N; Raul, F; Schleiffer, R; Schneider, Y | 1 |
| Corpet, DE; Parnaud, G; Peiffer, G; Pignatelli, B; Taché, S | 1 |
| Hosokawa, M; Kohno, H; Okumura, A; Takashima, S; Tanaka, T; Yamaguchi, N; Yoshitani , S | 1 |
| Azuma, N; Iwami, K; Kanamoto, R; Saeki, T; Suda, H; Tsuchihashi, Y | 1 |
| Hara, A; Hirose, Y; Katayama, M; Kuno, T; Mori, H; Qiao, Z; Shimizu, M; Yamada, Y; Yoshimi, N | 1 |
| Alexander, J; Husøy, T; Løberg, EM; Namork, E; Paulsen, JE; Steffensen, IL | 1 |
| Kato, N; Komatsu, SI; Nii, H; Oka, T; Tsuge, H; Watanabe, H | 1 |
| Imai, H; Kawamori, T; Nakagama, H; Ochiai, M; Sugimura, T; Ubagai, T | 1 |
| Cui, H; Giardina, C; Guda, K; Nambiar, P; Rosenberg, DW | 1 |
| Hidvégi, M; Lapis, K; Rásó, E; Szende, B; Telekes, A; Zalatnai, A | 1 |
| Kohno, H; Takashima, S; Tanaka, T; Yoshitani, SI | 1 |
| Kohno, H; Koshimizu, K; Mori, H; Murakami, A; Ohigashi, H; Safitri, R; Shimizu, M; Takahashi, D; Tanaka, T; Tsukio, Y; Yamamoto, K; Yoshitani, S | 1 |
| Carroll, RJ; Chang, WC; Chapkin, RS; Davidson, LA; Hong, MY; Lupton, JR; Morris, JS; Turner, ND; Wang, N | 1 |
| Dai, W; Liu, T; Rao, CV; Reddy, BS; Wang, Q | 1 |
| Aly, A; Baldwin, GS; Shulkes, A | 1 |
| Meline, B; Singletary, KW | 1 |
| Kawamori, T; Kitamura, T; Kobayashi, K; Kobayashi, M; Maruyama, T; Mutoh, M; Narumiya, S; Ohuchida, S; Shoji, Y; Sugimoto, Y; Sugimura, T; Takahashi, M; Tani, K; Wakabayashi, K; Watanabe, K | 1 |
| Connor, JR; Indranie, C; Manning, PT; Rao, CV; Reddy, BS; Simi, B | 1 |
| Hara, Y; Hasegawa, J; Isemura, M; Kishimoto, Y; Kohri, T; Miura, N; Ohishi, T; Shiota, G | 1 |
| Arika, T; Asano, R; Baba, M; Nishino, H; Ohmura, M; Okada, Y; Okuyama, T; Sugimoto, H; Takahashi, T; Takigami, I | 1 |
| Hosokawa, M; Kohno, H; Miyashita, K; Noguchi, R; Suzuki, R; Tanaka, T | 1 |
| Bailey, G; Casto, B; Pereira, C; Ralston, S; Roebuck, B; Stoner, G | 1 |
| Arimochi, H; Intiyot, Y; Kataoka, K; Kinouchi, T; Kuwahara, T; Ohnishi, Y; Vinitketkumnuen, U | 1 |
| Houchi, H; Momen, MA; Monden, Y; Umemoto, A | 1 |
| Hara, A; Hirose, Y; Katayama, M; Kuno, T; Mori, H; Saji, S; Sakata, K; Yamada, Y | 1 |
| Hasegawa, J; Kawasaki, H; Kishimoto, Y; Morisawa, T; Shiota, G; Yashima, K | 1 |
| Frankel, WL; Gallaher, DD; Gupta, A; Habib, SG; Harris, GK; Kresty, LA; LaPerle, K; Nines, RG; Schwartz, SJ; Stoner, GD | 1 |
| Ahn, BO; Green, J; Hahm, KB; Han, SU; Hong, WS; Kim, MW; Kim, SJ; Kim, YB; Lee, KM; Lee, MH; Lee, WH; Oh, TY | 1 |
| Davis, CD; Johnson, WT | 1 |
| Kat, N; Komatsu, S; Oka, T; Tsuge, H; Watanabe, H | 1 |
| Moriwaki, H; Nakagama, H; Okuno, M; Suzui, M; Tanaka, T | 1 |
| Kohno, H; Maeda, M; Mori, H; Sugie, S; Tanaka, T; Tanino, M; Tsukio, Y; Ueda, N; Wada, K | 1 |
| Pool-Zobel, B; Roberfroid, MB; Rowland, I; van Loo, J | 1 |
| Archer, MC; Ealey, KN; el-Sohemy, A | 1 |
| Buzzigoli, C; Caderni, G; Cocca, E; Dolara, P; Femia, AP; Salvadori, M | 1 |
| Aizu, W; Giardina, C; Guda, K; Nambiar, PR; Raja, R; Rosenberg, DW | 1 |
| Ward, JM | 1 |
| Borchert, P; Fladmoe, AV; Lam, LK; Wattenberg, LW | 1 |
| Miyazawa, T; Moriya, M; Ohta, T; Shirasu, Y; Sugiyama, F; Watanabe, K; Watanabe, Y | 1 |
| Kritchevsky, D; Reddy, BS; Watanabe, K; Weisburger, JH | 1 |
| Frank, N; Wiessler, M; Zedeck, MS | 1 |
| Bauer, FL; Malt, RA; Ross, JS; Watkins, JB; Williamson, RC | 1 |
| Brown, CA | 1 |
| Bauer, FL; Malt, RA; Oscarson, JE; Ross, JS; Williamson, RC | 1 |
| Reddy, BS; Watanabe, K; Weisburger, JH; Wong, CQ | 1 |
| Sugimura, T | 1 |
| Berkvens, JM; Kroes, R; Weisburger, JH | 1 |
| Fiala, E | 1 |
| Narisawa, T; Reddy, BS; Weisburger, JH | 1 |
| Klurfeld, DM | 1 |
| Alabaster, O; Shivapurkar, N; Tang, ZC | 1 |
| Boeryd, B; Hallböök, O; Lilja, I; Sjödahl, R | 1 |
| Amini, SB; O'Riordan, MA; Pretlow, TG; Pretlow, TP; Somich, GA | 1 |
| Bird, RP; Murphy, LC; Stopera, SA | 1 |
| Kendall, CW; Koo, M; Rao, AV; Sokoloff, E | 1 |
| Archer, MC; Bruce, WR; Chan, CC; Corpet, DE; Medline, A; Roncucci, L; Stamp, D; Zhang, XM | 1 |
| Baba, M; Iishi, H; Taniguchi, H; Tatsuta, M; Yamamoto, R | 1 |
| Baba, M; Iishi, H; Okuda, S; Taniguchi, H; Tatsuta, M | 4 |
| Friday, D; Janezic, SA; Kendall, CW; Rao, AV | 1 |
| Aligia, C; Kelloff, G; Kulkarni, N; Reddy, BS; Tokumo, K | 1 |
| el-Bayoumy, K; Nayini, JR; Rao, CV; Reddy, BS; Rigotty, J; Sohn, OS; Sugie, S | 1 |
| Coghlan, L; Price, RE; Satterfield, W; Stephens, LC; Wargovich, MJ | 1 |
| Akachi, S; Hagiwara, N; Inagake, M; Kim, M; Kitao, Y; Kuwata, K; Okuzumi, J; Takahashi, T; Tateishi, M; Yamane, T | 1 |
| Burill, C; Reddy, BS; Rigotty, J | 1 |
| Floyd, J; Golightly, S; Gordon, GB; Hamilton, SR | 1 |
| Khoury, MD; Pereira, MA | 1 |
| Ballet, F; Delelo, R; Herve, JP; Nordlinger, B; Panis, Y; Puts, JP | 1 |
| Cooke, T; Reeves, JR; Richards, RC | 1 |
| Baba, M; Ichii, M; Iishi, H; Nakaizumi, A; Taniguchi, H; Tatsuta, M; Uehara, H | 1 |
| Nayini, J; Rao, CV; Reddy, BS | 1 |
| el-Bayoumy, K; Fiala, ES; Joseph, C; Reddy, BS; Sohn, OS | 1 |
| Bird, RP; McLellan, E | 1 |
| Dornschneider, G; Eibl-Eibesfeldt, B; Hamilton, SR; Harnisch, E; Izbicki, JR; Schweiberer, L; Wambach, G; Wilker, DK | 1 |
| Baba, M; Iishi, H; Taniguchi, H; Tasuta, M | 1 |
| Archer, MC; Bruce, WR; Corpet, DE; Medline, A; Minkin, S; Stamp, D | 1 |
| Flick, JA; Hamilton, SR; Perman, JA; Rosales, FJ | 1 |
| Deschner, EE; Lupton, JR; Newmark, HL; Ruperto, JF | 1 |
| Appleton, GV; Davies, PW; Williamson, RC | 1 |
| Henly, PJ; Hill, MJ; Houghton, PW; Mortensen, NJ; Owen, RJ; Williamson, RC | 1 |
| Kumar, SP; Reddy, BS; Roy, SJ; Tokumo, K | 1 |
| Allnutt, D; Anaya, P; Palmer, C; Stephens, LC; Wargovich, MJ | 1 |
| Hamilton, SR; Luk, GD; Zhang, SZ | 2 |
| Guillem, J; Lambert, ME; O'Toole, K; Ornstein, L; Tulchin, N; Weinstein, IB | 1 |
| Barth, RF; Downie, AA; Dwivedi, C; Oredipe, OA; Webb, TE | 1 |
| Donegan, WL; Kusama, K; Samter, TG | 1 |
| Fujimaki, M; Tazawa, K; Yamashita, I | 1 |
| Carr, K; Galloway, DJ; George, WD; Indran, M; Jarrett, F | 1 |
| Elsayed, AM; Shamsuddin, AM; Ullah, A | 1 |
| Hioki, K; Minoura, T; Sakaguchi, M; Takada, H; Takata, T; Yamamoto, M; Yamamura, M | 1 |
| Shamsuddin, AM; Ullah, A | 1 |
| Hamilton, SR; Harnisch, E; Hogenschurz, R; Izbicki, JR; Izbicki, W; Kusche, J; Wambach, G | 1 |
| El-Bayoumy, K; Reddy, BS; Tanaka, T | 1 |
| Boyle, P; Galloway, DJ; George, WD; Hill, MJ; Jarrett, F; Owen, RW | 1 |
| Boyle, P; Carr, K; Galloway, DJ; George, WD; Indran, M; Jarrett, F; Owen, RW | 1 |
| Broitman, SA | 1 |
| Fiala, ES; Hamilton, SR; Sohn, OS | 2 |
| Bird, RP; McLellan, EA | 1 |
| Reddy, BS; Sugie, S | 1 |
| Lowenfels, A; Reddy, BS; Sugie, S | 1 |
| Baba, M; Iishi, H; Taniguchi, H; Tatsuta, M; Yamamura, H | 1 |
| Marra, P; Maruyama, H; Reddy, BS; Sugie, S | 1 |
| Bird, RP; Goettler, DM; Rao, AV | 1 |
| Bloom, SR; Cooke, T; Matthews, JL; Savage, AP; Sian, MS | 1 |
| Forde, KA; Guillem, JG; Hsieh, LL; LoGerfo, P; O'Toole, KM; Weinstein, IB | 1 |
| Reddy, BS; Tanaka, T | 1 |
| Maruyama, H; Reddy, BS | 2 |
| Nauss, KM; Newberne, PM | 1 |
| Donegan, WL; Hamilton, SR | 1 |
| Kelloff, G; Maruyama, H; Reddy, BS | 1 |
| Fermor, B; Roe, R; Williamson, RC | 1 |
| el-Bayoumy, K; Marra, P; Maruyama, H; Reddy, BS; Sugie, S | 1 |
| Cooke, T; Matthews, J | 1 |
| Goeting, NL; Taylor, I; Trotter, GA | 1 |
| Hamilton, SR; Hyland, J; Luk, GD; McAvinchey, D; O'Ceallaigh, D; Smith, JA; Yang, P | 1 |
| Maruyama, H; Reddy, BS; Wang, CX | 1 |
| Chaudhry, Y; Cichon, P; Floyd, J; Hamilton, SR; Hartka, L; Hyland, J; Kessie, G; Kim, HT; McAvinchey, D; Turjman, N | 1 |
| Bloom, SR; Bristol, JB; Ghatei, MA; Smith, JH; Williamson, RC | 1 |
| Bloom, SR; Cooke, T; Ghatei, MA; Matthews, JL; Savage, AP | 1 |
| Boitnott, JK; Hamilton, SR; Hyland, J; Pan, Q | 1 |
| Reddy, BS; Simi, B; Tanaka, T | 1 |
| Yardley, JH | 1 |
| Hioki, K; Hiramatsu, Y; Minoura, T; Sakaguchi, M; Takada, H; Yamamoto, M; Yamamura, M | 1 |
| Clamp, JR; Corfield, AP; Rainey, JB; Wagner, SA | 1 |
| Cooke, T; Goeting, N; Kirkham, N; Taylor, I; Trotter, GA | 1 |
| Goeting, N; Summerton, J; Taylor, I; Trotter, GA | 1 |
| Choi, CI; Numoto, S; Reddy, BS | 1 |
14 review(s) available for azoxymethane and Colonic Neoplasms
| Article | Year |
|---|---|
Murine Model for Colitis-Associated Cancer of the Colon.
Topics: Animals; Azoxymethane; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Female; Humans; Male; Mice | 2016 |
Azoxymethane-induced rat aberrant crypt foci: relevance in studying chemoprevention of colon cancer.
Topics: Animals; Azoxymethane; Biomarkers, Tumor; Carcinogens; Chemoprevention; Colon; Colonic Neoplasms; Disease Models, Animal; Humans; Precancerous Conditions; Rats | 2008 |
The signal pathways in azoxymethane-induced colon cancer and preventive implications.
Topics: Adenocarcinoma; Adenoma; Adiponectin; Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Carcinogens; Colonic Neoplasms; Cytochrome P-450 CYP2E1; Diet; DNA Damage; Genes, ras; Humans; MAP Kinase Signaling System; Methylazoxymethanol Acetate; Mice; Mice, Knockout; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Transforming Growth Factor beta; Transforming Growth Factor beta2 | 2009 |
Morphological and molecular alterations in 1,2 dimethylhydrazine and azoxymethane induced colon carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Azoxymethane; Biomarkers, Tumor; Colonic Neoplasms; Humans; Precancerous Conditions; Rats; Terminology as Topic | 2011 |
Counterpoint: From animal models to prevention of colon cancer. Criteria for proceeding from preclinical studies and choice of models for prevention studies.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Chemoprevention; Colonic Neoplasms; Diet; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Mice; Mice, Mutant Strains; Precancerous Conditions; Randomized Controlled Trials as Topic; Rats | 2003 |
Point: From animal models to prevention of colon cancer. Systematic review of chemoprevention in min mice and choice of the model system.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Chemoprevention; Colonic Neoplasms; Diet; Disease Models, Animal; Humans; Mice; Mice, Mutant Strains; Precancerous Conditions; Randomized Controlled Trials as Topic; Rats | 2003 |
Gene mutations and altered gene expression in azoxymethane-induced colon carcinogenesis in rodents.
Topics: Animals; Azoxymethane; beta Catenin; Colonic Neoplasms; Cyclooxygenase 2; Cytoskeletal Proteins; Gene Expression Regulation; Genes, ras; Humans; Isoenzymes; Membrane Proteins; Mutation; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin-Endoperoxide Synthases; Trans-Activators | 2004 |
Studies with the azoxymethane-rat preclinical model for assessing colon tumor development and chemoprevention.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoxymethane; Chemoprevention; Colonic Neoplasms; Cyclooxygenase 2; Disease Models, Animal; Dose-Response Relationship, Drug; Eflornithine; Fatty Acids, Omega-3; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isoenzymes; Membrane Proteins; Models, Biological; Piroxicam; Prostaglandin-Endoperoxide Synthases; Rats; Risk Assessment | 2004 |
Role of aberrant crypt foci in understanding the pathogenesis of colon cancer.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Azoxymethane; Carcinogens; Cholic Acid; Cholic Acids; Colon; Colonic Neoplasms; Dietary Fats; Dimethylhydrazines; Genes, ras; Humans; Intestinal Mucosa; Precancerous Conditions | 1995 |
COX-2 and iNOS, good targets for chemoprevention of colon cancer.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Colonic Neoplasms; Cyclooxygenase 2; Dinoprostone; Enzyme Inhibitors; Humans; Isoenzymes; Membrane Proteins; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin-Endoperoxide Synthases; Rats; Receptors, Prostaglandin E; Sulfonamides | 2000 |
Experimental evidences on the potential of prebiotic fructans to reduce the risk of colon cancer.
Topics: Animals; Apoptosis; Azoxymethane; Bifidobacterium; Colon; Colonic Neoplasms; Dietary Fiber; Fatty Acids, Volatile; Fermentation; Fructans; Humans; Intestinal Mucosa; Inulin; Lactobacillus; Mice; Models, Animal; Rats | 2002 |
Dietary fiber-mediated mechanisms in carcinogenesis.
Topics: Animals; Azoxymethane; Bile Acids and Salts; Colon; Colonic Neoplasms; Denmark; Dietary Fiber; Dimethylhydrazines; Fatty Acids, Volatile; Feces; Fermentation; Finland; Growth Substances; Humans; Ornithine Decarboxylase; Rats; Rectal Neoplasms | 1992 |
Cholesterol conundrums: the relationship between dietary and serum cholesterol in colon cancer.
Topics: 1,2-Dimethylhydrazine; Adult; Animals; Azoxymethane; Cholesterol; Cholesterol, Dietary; Cholestyramine Resin; Cocarcinogenesis; Colonic Neoplasms; Diagnosis-Related Groups; Dietary Fats; Dimethylhydrazines; Disease Models, Animal; Epidemiologic Methods; Humans; Methylnitronitrosoguanidine; Methylnitrosourea | 1986 |
Dietary fat and colon cancer: variable results in animal models.
Topics: 1,2-Dimethylhydrazine; Animals; Azoxymethane; Body Weight; Cocarcinogenesis; Colonic Neoplasms; Dietary Fats; Dimethylhydrazines; Disease Models, Animal; Energy Intake; Gastrointestinal Neoplasms; Meat | 1986 |
1 trial(s) available for azoxymethane and Colonic Neoplasms
| Article | Year |
|---|---|
Targeting Colon Luminal Lipid Peroxidation Limits Colon Carcinogenesis Associated with Red Meat Consumption.
Topics: Adult; Animals; Azoxymethane; Biomarkers; Carcinogenesis; Carcinogens; Colonic Neoplasms; Cooking; Cross-Over Studies; Feces; Female; Healthy Volunteers; Heme; Humans; Lipid Peroxidation; Male; Mice; Middle Aged; Neoplasms, Experimental; Rats; Rats, Inbred F344; Red Meat | 2018 |
1085 other study(ies) available for azoxymethane and Colonic Neoplasms
| Article | Year |
|---|---|
Suppression of C-C chemokine receptor 1 is a key regulation for colon cancer chemoprevention in AOM/DSS mice by fucoxanthin.
Topics: Animals; Azoxymethane; Chemokines, CC; Colonic Neoplasms; Cyclin D1; Dextran Sulfate; Disease Models, Animal; Humans; Male; Mice; Mice, Inbred ICR; Proto-Oncogene Proteins c-akt; Receptors, CCR1; Smad2 Protein; Xanthophylls | 2022 |
Selenium and the 15kDa Selenoprotein Impact Colorectal Tumorigenesis by Modulating Intestinal Barrier Integrity.
Topics: Aberrant Crypt Foci; Animals; Azoxymethane; Carcinogenesis; Colonic Neoplasms; Cytokines; Dextran Sulfate; Diet; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Intestinal Mucosa; Male; Mice; Mice, Knockout; Selenoproteins; Signal Transduction; Sodium Selenite; Trace Elements | 2021 |
Applications and Mechanism of 3-Hydroxybutyrate (3HB) for Prevention of Colonic Inflammation and Carcinogenesis as a Food Supplement.
Topics: 3-Hydroxybutyric Acid; Animals; Azoxymethane; Carcinogenesis; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Dietary Supplements; Disease Models, Animal; Inflammation; Mice; Mice, Inbred C57BL | 2021 |
Assessment of the Anti-Cancer Efficiency of Silver Moringa oleifera Leaves Nano-extract against Colon Cancer Induced Chemically in Rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; Azoxymethane; CA-19-9 Antigen; Carcinoembryonic Antigen; Carcinogens; Colonic Neoplasms; Electrophoresis, Polyacrylamide Gel; Gene Expression; Genes, APC; Metal Nanoparticles; Moringa oleifera; Neoplasm Proteins; Oxidative Stress; Plant Extracts; Plant Leaves; Random Allocation; Rats; Silver; Tumor Suppressor Protein p53 | 2021 |
Protective Role of Spermidine in Colitis and Colon Carcinogenesis.
Topics: Adenomatous Polyposis Coli Protein; alpha-Defensins; Animals; Azoxymethane; Carcinogenesis; Colitis; Colitis, Ulcerative; Colon; Colonic Neoplasms; Dextran Sulfate; Gastrointestinal Microbiome; Gene Expression Regulation; Humans; Intestinal Mucosa; Male; Mice; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Precancerous Conditions; Protective Factors; RNA, Messenger; Severity of Illness Index; Spermidine; Weight Loss | 2022 |
Correlation Between THSD7A Expression and Tumor Characteristics of Azoxymethane-Induced Colon Cancer Model in Rats.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Ki-67 Antigen; Rats; ROC Curve; Thrombospondins | 2021 |
Regulation of gene expression in the development of colitis-associated colon cancer in mice fed a high-fat diet.
Topics: Animals; Azoxymethane; Colitis-Associated Neoplasms; Colonic Neoplasms; Dextran Sulfate; Diet, High-Fat; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Male; Mice, Inbred C57BL | 2022 |
T-Cell-Specific CerS4 Depletion Prolonged Inflammation and Enhanced Tumor Burden in the AOM/DSS-Induced CAC Model.
Topics: Animals; Azoxymethane; Colitis-Associated Neoplasms; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Humans; Jurkat Cells; Mice; Mice, Knockout; NF-kappa B; Organ Specificity; Receptors, Antigen, T-Cell; Signal Transduction; Sphingosine N-Acyltransferase; T-Lymphocytes; Tumor Burden | 2022 |
Type-2 cGMP-dependent protein kinase suppresses proliferation and carcinogenesis in the colon epithelium.
Topics: Animals; Azoxymethane; Carcinogenesis; Cell Proliferation; Colon; Colonic Neoplasms; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type II; Dextran Sulfate; Epithelium; Mice; Mice, Inbred C57BL; Mice, Knockout | 2022 |
Two hydroxyflavanones isolated from Scutellaria baicalensis roots prevent colitis-associated colon cancer in C57BL/6 J mice by inhibiting programmed cell death-1, interleukin 10, and thymocyte selection-associated high mobility group box proteins TOX/TOX2
Topics: Animals; Apoptosis; Azoxymethane; Colitis; Colitis-Associated Neoplasms; Colon; Colonic Neoplasms; Cyclooxygenase 2; Dextran Sulfate; HMGB Proteins; Interleukin-10; Mice; Mice, Inbred C57BL; Programmed Cell Death 1 Receptor; Scutellaria baicalensis; Thymocytes; Tumor Microenvironment | 2022 |
Topics: Animals; Azoxymethane; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Dysbiosis; Gastrointestinal Microbiome; Inflammation; Lactobacillaceae; Metabolome; Mice; Mice, Inbred C57BL | 2022 |
In vivo antitumor activity of Euphorbia lathyris ethanol extract in colon cancer models.
Topics: Azoxymethane; Colonic Neoplasms; Dextran Sulfate; Ethanol; Euphorbia; Humans; Plant Extracts | 2022 |
Changes in Gut Microbiome upon Orchiectomy and Testosterone Administration in AOM/DSS-Induced Colon Cancer Mouse Model.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Colorectal Neoplasms; Disease Models, Animal; Female; Gastrointestinal Microbiome; Male; Mice; Orchiectomy; Phylogeny; RNA, Ribosomal, 16S; Testosterone | 2023 |
MUC1-mediated Macrophage Activation Promotes Colitis-associated Colorectal Cancer via Activating the Interleukin-6/ Signal Transducer and Activator of Transcription 3 Axis.
Topics: Animals; Azoxymethane; Carcinogenesis; Chemotactic Factors; Colitis; Colitis-Associated Neoplasms; Colonic Neoplasms; Dextran Sulfate; Interleukin-6; Macrophage Activation; Mice; Mice, Knockout; Mucin-1; STAT3 Transcription Factor | 2022 |
Dietary Energy Intake and Presence of Aberrant Crypt Foci Are Associated with Phospholipid, Purine, and Taurine Metabolite Abundances in C57BL/6N Mouse Colon.
Topics: Aberrant Crypt Foci; Animals; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Diet; Energy Intake; Mice; Mice, Inbred C57BL; Phospholipids; Precancerous Conditions; Purines; Taurine | 2022 |
Unexpected Liver and Kidney Pathology in C57BL/6J Mice Fed a High-fat Diet and Given Azoxymethane to Induce Colon Cancer.
Topics: Animals; Azoxymethane; Colon; Colonic Neoplasms; Cycasin; Dextrans; Diet; Diet, High-Fat; Kidney; Liver; Mice; Mice, Inbred C57BL | 2022 |
6- shogaol suppresses AOM/DSS-mediated colorectal adenoma through its antioxidant and anti-inflammatory effects in mice.
Topics: Adenoma; Animals; Anti-Inflammatory Agents; Antioxidants; Azoxymethane; Colonic Neoplasms; Colorectal Neoplasms; Disease Models, Animal; Inflammation; Male; Mice | 2022 |
Polysaccharide of Lactobacillus casei SB27 reduced colon cancer cell prognosis through mitochondrial damage by upregulation of HINT2.
Topics: Animals; Azoxymethane; Calcium; Colonic Neoplasms; Dextran Sulfate; Humans; Hydrolases; Lacticaseibacillus casei; Mice; Mitochondrial Proteins; Prognosis; Up-Regulation | 2023 |
Butyrate ameliorates colorectal cancer through regulating intestinal microecological disorders.
Topics: Animals; Azoxymethane; Butyrates; Colonic Neoplasms; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Mice; Mice, Inbred C57BL | 2023 |
Identification of natural product 3, 5-diiodotyrosine as APOBEC3B inhibitor to prevent somatic mutation accumulation and cancer progression.
Topics: Animals; Azoxymethane; B7-H1 Antigen; Biological Products; Colitis; Colonic Neoplasms; Diiodotyrosine; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Interleukin-15; Mice; Minor Histocompatibility Antigens; Mutation Accumulation; Programmed Cell Death 1 Receptor; Tumor Microenvironment | 2022 |
The Appendix Orchestrates T-Cell Mediated Immunosurveillance in Colitis-Associated Cancer.
Topics: Animals; Appendicitis; Appendix; Azoxymethane; Colitis-Associated Neoplasms; Colitis, Ulcerative; Colonic Neoplasms; Humans; Male; Mice; Monitoring, Immunologic | 2023 |
Investigation of the gut microbiome, bile acid composition and host immunoinflammatory response in a model of azoxymethane-induced colon cancer at discrete timepoints.
Topics: Animals; Azoxymethane; Bile Acids and Salts; Carcinogenesis; Chromatography, Liquid; Colon; Colonic Neoplasms; Disease Models, Animal; Gastrointestinal Microbiome; Mice; RNA, Ribosomal, 16S; Tandem Mass Spectrometry | 2023 |
CCL17 Promotes Colitis-Associated Tumorigenesis Dependent on the Microbiota.
Topics: Animals; Azoxymethane; Carcinogenesis; Cell Transformation, Neoplastic; Chemokine CCL17; Colitis; Colonic Neoplasms; Gastrointestinal Microbiome; Mice | 2022 |
AC1Q3QWB inhibits colorectal cancer progression by modulating the immune response and balancing the structure of the intestinal microbiota.
Topics: Animals; Azoxymethane; Colitis; Colon; Colonic Neoplasms; Colorectal Neoplasms; Dextran Sulfate; Dimethyl Sulfoxide; Disease Models, Animal; Gastrointestinal Microbiome; Immunity; Mice; Mice, Inbred C57BL; RNA, Ribosomal, 16S | 2023 |
Sleep Fragmentation Accelerates Carcinogenesis in a Chemical-Induced Colon Cancer Model.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Azoxymethane; Carcinogenesis; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Mice; Mice, Inbred C57BL; Reactive Oxygen Species; Sleep Deprivation | 2023 |
Combining gamma-tocopherol and aspirin synergistically suppresses colitis-associated colon tumorigenesis and modulates the gut microbiota in mice, and inhibits the growth of human colon cancer cells.
Topics: Animals; Aspirin; Azoxymethane; Carcinogenesis; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Dextran Sulfate; gamma-Tocopherol; Gastrointestinal Microbiome; Humans; Mice; Mice, Inbred C57BL | 2023 |
Acertannin prevents azoxymethane/dextran sulfate sodium-induced colon cancer growth by inhibiting the colonic expression of interleukin-1β, monocyte chemoattractant protein-1, cyclooxygenase-2, and thymocyte selection-associated high mobility group box pr
Topics: Animals; Azoxymethane; Chemokine CCL2; Colon; Colonic Neoplasms; Cyclooxygenase 2; Dextran Sulfate; Interleukin-10; Interleukin-1beta; Mice; Mice, Inbred C57BL; Programmed Cell Death 1 Receptor; Tannins; Tumor Microenvironment | 2023 |
Geniposide prevents tumor growth by inhibiting colonic interleukin-1β and monocyte chemoattractant protein-1 via down-regulated expression of cyclooxygenase-2 and thymocyte selection-associated high mobility box proteins TOX/TOX2 in azoxymethane/dextran s
Topics: Animals; Azoxymethane; Chemokine CCL2; Colitis; Colonic Neoplasms; Cyclooxygenase 2; Dextran Sulfate; Interleukin-10; Interleukin-1beta; Mice; Mice, Inbred C57BL; Programmed Cell Death 1 Receptor; Thymocytes | 2023 |
[Anemoside B4 regulates fatty acid metabolism reprogramming in mice with colitis-associated cancer].
Topics: Animals; Azoxymethane; Colitis; Colitis-Associated Neoplasms; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Mice; Mice, Inbred C57BL; PPAR alpha; RNA, Messenger; Sterol Regulatory Element Binding Protein 1 | 2023 |
Inhibitory Effect of Zinc on Colorectal Cancer by Granzyme B Transcriptional Regulation in Cytotoxic T Cells.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Colorectal Neoplasms; Dextran Sulfate; Granzymes; Mice; T-Lymphocytes, Cytotoxic; Zinc | 2023 |
Altered gut microbiota of obesity subjects promotes colorectal carcinogenesis in mice.
Topics: Animals; Azoxymethane; Carcinogenesis; Colonic Neoplasms; Colorectal Neoplasms; Disease Models, Animal; Gastrointestinal Microbiome; Humans; Mice; Mice, Inbred C57BL; Obesity | 2023 |
Anticancer Effects of Washed-Dehydrated Solar Salt Doenjang on Colon Cancer-Induced C57BL/6 Mice.
Topics: Animals; Azoxymethane; Colitis; Colon; Colonic Neoplasms; Cytokines; Dextran Sulfate; Inflammation; Interleukin-6; Mice; Mice, Inbred C57BL; Sodium Chloride, Dietary; Tumor Necrosis Factor-alpha | 2023 |
Beneficial effects of alpha-1 antitrypsin therapy in a mouse model of colitis-associated colon cancer.
Topics: Animals; Azoxymethane; Colitis; Colitis-Associated Neoplasms; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Humans; Inflammatory Bowel Diseases; Mice; Mice, Inbred C57BL | 2023 |
Fecal microbiota transplanted from old mice promotes more colonic inflammation, proliferation, and tumor formation in azoxymethane-treated A/J mice than microbiota originating from young mice.
Topics: Animals; Azoxymethane; Carcinogenesis; Cell Proliferation; Colonic Neoplasms; Fecal Microbiota Transplantation; Gastrointestinal Microbiome; Inflammation; Mice; Microbiota | 2023 |
Helminth-derived molecules inhibit colitis-associated colon cancer development through NF-κB and STAT3 regulation.
Topics: Animals; Anti-Inflammatory Agents; Azoxymethane; Cell Proliferation; Cell Survival; Colitis; Colonic Neoplasms; Disease Models, Animal; Female; Helminth Proteins; Humans; Interleukin-1beta; Interleukin-33; Mice; NF-kappa B; Phosphorylation; Proto-Oncogene Mas; STAT3 Transcription Factor; Taenia; Tumor Necrosis Factor-alpha | 2019 |
Thermally Processed Oil Exaggerates Colonic Inflammation and Colitis-Associated Colon Tumorigenesis in Mice.
Topics: Animals; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Hot Temperature; Humans; Inflammation; Male; Mice; Mice, Inbred C57BL; Oils | 2019 |
Intermittent Dosing Regimens of Aspirin and Naproxen Inhibit Azoxymethane-Induced Colon Adenoma Progression to Adenocarcinoma and Invasive Carcinoma.
Topics: Adenocarcinoma; Adenoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Azoxymethane; Carcinogens; Colonic Neoplasms; Dose-Response Relationship, Drug; Male; Naproxen; Neoplasm Invasiveness; Rats; Rats, Wistar | 2019 |
Polysaccharides isolated from Nostoc commune Vaucher inhibit colitis-associated colon tumorigenesis in mice and modulate gut microbiota.
Topics: Animals; Azoxymethane; Bacteria; Carcinogenesis; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Fatty Acids, Volatile; Feces; Gastrointestinal Microbiome; Male; Mice; Mice, Inbred C57BL; Nostoc commune; Polysaccharides; RNA, Ribosomal, 16S | 2019 |
Chemopreventive efficacy of juniper berry oil (
Topics: Animals; Azoxymethane; Carcinogenesis; Colon; Colonic Neoplasms; Juniperus; Male; Plant Oils; Rats; Rats, Wistar | 2021 |
Dietary Tricin Suppresses Inflammation-Related Colon Carcinogenesis in Mice.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Carcinogenesis; Colitis; Colon; Colonic Neoplasms; Cytokines; Dextran Sulfate; Diet; Flavonoids; Male; Mice; Tumor Necrosis Factor-alpha | 2019 |
Saccharomyces boulardii alleviates ulcerative colitis carcinogenesis in mice by reducing TNF-α and IL-6 levels and functions and by rebalancing intestinal microbiota.
Topics: Animals; Azoxymethane; Bacteria; Caco-2 Cells; Cell Line, Tumor; Colitis, Ulcerative; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Down-Regulation; Feces; Gastrointestinal Microbiome; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Interleukin-6; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Saccharomyces boulardii; Tumor Necrosis Factor-alpha | 2019 |
Bisphosphonates Zometa and Fosamax Synergize with Metformin to Prevent AOM-Induced Colon Cancer in F344 Rat Model.
Topics: Administration, Oral; Alendronate; Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Cell Proliferation; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Humans; Male; Metformin; Neoplasms, Experimental; Rats; Rats, Inbred F344; Zoledronic Acid | 2020 |
Colon Cancer Prevention with Walnuts: A Longitudinal Study in Mice from the Perspective of a Gut Enterotype-like Cluster.
Topics: Animals; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Diet, Western; Feces; Feeding Behavior; Female; Gastrointestinal Microbiome; Humans; Intestinal Mucosa; Juglans; Longitudinal Studies; Male; Mice; Neoplasms, Experimental; Nuts; Tumor Burden | 2020 |
Role of transient receptor potential vanilloid subtype 4 in the regulation of azoymethane/dextran sulphate sodium-induced colitis-associated cancer in mice.
Topics: Animals; Azoxymethane; Carcinogenesis; Carcinogens; Cell Proliferation; Chemokine CXCL2; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Progression; Human Umbilical Vein Endothelial Cells; Humans; Intestinal Mucosa; Macrophages; Male; Mice; Mice, Knockout; Neoplasms, Experimental; TRPV Cation Channels | 2020 |
Identification and Characterization of Unique Neutralizing Antibodies to Mouse EGF Receptor.
Topics: Animals; Antibodies, Monoclonal, Humanized; Antibodies, Neutralizing; Azoxymethane; Carcinogens; Cells, Cultured; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; ErbB Receptors; Gastritis, Hypertrophic; Genes, Reporter; Hepatocytes; Humans; Mice; Mice, Transgenic; Primary Cell Culture | 2020 |
Role of TNFα and leptin signaling in colon cancer incidence and tumor growth under obese phenotype.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Azoxymethane; Colonic Neoplasms; Colonic Polyps; Dextran Sulfate; Diet, High-Fat; Gene Knockdown Techniques; HCT116 Cells; Humans; Incidence; Leptin; Mice; Mice, Knockout; Mice, Obese; Neoplasms, Experimental; Obesity; Recombinant Proteins; Signal Transduction; Tumor Necrosis Factor-alpha; Tumor Suppressor Proteins; Up-Regulation | 2020 |
Effects of high-fat diet and intestinal aryl hydrocarbon receptor deletion on colon carcinogenesis.
Topics: Animals; Azoxymethane; Basic Helix-Loop-Helix Transcription Factors; beta Catenin; Cell Proliferation; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Diet, High-Fat; Disease Models, Animal; DNA Damage; Epithelial Cells; Gene Deletion; Gene Expression Regulation, Neoplastic; Intestinal Mucosa; Mice, Inbred C57BL; Mice, Knockout; Precancerous Conditions; Receptors, Aryl Hydrocarbon; Signal Transduction | 2020 |
Reduction of colitis-associated colon carcinogenesis by a black lentil water extract through inhibition of inflammatory and immunomodulatory cytokines.
Topics: Animals; Azoxymethane; Carcinogenesis; Carcinogens; Colitis; Colonic Neoplasms; Cytokines; Dextran Sulfate; Fabaceae; Gene Expression Profiling; Inflammation; Male; Mice; Mice, Inbred C57BL; Plant Extracts; Water | 2020 |
Protective Effects of Zerumbone on Colonic Tumorigenesis in Enterotoxigenic
Topics: Administration, Oral; Animals; Azoxymethane; Bacteroides fragilis; Body Weight; Carcinogenesis; Colitis; Colonic Neoplasms; Dextran Sulfate; Female; Mice; Mice, Inbred BALB C; Protective Agents; Sesquiterpenes; Severity of Illness Index | 2020 |
Parabacteroides distasonis attenuates tumorigenesis, modulates inflammatory markers and promotes intestinal barrier integrity in azoxymethane-treated A/J mice.
Topics: Animals; Azoxymethane; Bacteroidetes; Carcinogenesis; Colon; Colonic Neoplasms; Humans; Inflammation; Interleukin-4; Intestinal Mucosa; Mice; Obesity; Signal Transduction; Toll-Like Receptor 4; Transforming Growth Factor beta | 2020 |
Dietary Mixed Cereal Grains Ameliorate the Azoxymethane and Dextran Sodium Sulfate-Induced Colonic Carcinogenesis in C57BL/6J Mice.
Topics: Animals; Azoxymethane; Carcinogenesis; Caspase 3; Colon; Colonic Neoplasms; Colorectal Neoplasms; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Cyclooxygenase 2; Cytokines; Dextran Sulfate; Dietary Carbohydrates; Disease Models, Animal; Edible Grain; Interleukin-1beta; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; RNA, Messenger; Tumor Necrosis Factors; Tumor Suppressor Protein p53 | 2020 |
Alpha-Glucosidase Inhibitor Voglibose Suppresses Azoxymethane-Induced Colonic Preneoplastic Lesions in Diabetic and Obese Mice.
Topics: Animals; Antioxidants; Azoxymethane; Biomarkers; Biopsy; Cell Proliferation; Colonic Neoplasms; Cytokines; Diabetes Mellitus, Type 2; Disease Models, Animal; Glycoside Hydrolase Inhibitors; Humans; Inflammation Mediators; Inositol; Intestinal Mucosa; Mice; NF-kappa B; Obesity; Oxidative Stress; Precancerous Conditions | 2020 |
Catalpol‑mediated microRNA‑34a suppresses autophagy and malignancy by regulating SIRT1 in colorectal cancer.
Topics: Aged; Animals; Apoptosis; Autophagy; Azoxymethane; Carcinogens; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colonic Neoplasms; Colorectal Neoplasms; Disease Models, Animal; Drugs, Chinese Herbal; Female; Gene Expression Regulation, Neoplastic; Humans; Iridoid Glucosides; Male; MicroRNAs; Middle Aged; Rats; Rats, Wistar; Rehmannia; Sirtuin 1; Up-Regulation | 2020 |
Evaluation of the Biological Efficiency of Silver Nanoparticles Biosynthesized Using Croton tiglium L. Seeds Extract against Azoxymethane Induced Colon Cancer in Rats.
Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Croton; Male; Metal Nanoparticles; Oxidative Stress; Plant Extracts; Rats; Rats, Wistar; Seeds; Silver | 2020 |
Apple polysaccharide prevents from colitis-associated carcinogenesis through regulating macrophage polarization.
Topics: Animals; Azoxymethane; Carcinogenesis; Colitis; Colonic Neoplasms; Dextran Sulfate; Macrophages; Male; Malus; Mice; Mice, Inbred ICR; Polysaccharides; RAW 264.7 Cells; Signal Transduction; Toll-Like Receptor 4 | 2020 |
Consumption evaluation of one apple flesh a day in the initial phases prior to adenoma/adenocarcinoma in an azoxymethane rat colon carcinogenesis model.
Topics: Adenocarcinoma; Animals; Anthocyanins; Azoxymethane; Carcinogenesis; Colonic Neoplasms; Flavonoids; Fruit; Galactosides; Humans; Male; Malus; Plant Extracts; Polyphenols; Rats; Rats, Wistar | 2020 |
Dihydroxystilbenes prevent azoxymethane/dextran sulfate sodium-induced colon cancer by inhibiting colon cytokines, a chemokine, and programmed cell death-1 in C57BL/6J mice.
Topics: Animals; Apoptosis; Azoxymethane; Carcinogens; Chemokine CCL2; Chemokines; Colonic Neoplasms; Cyclooxygenase 2 Inhibitors; Cytokines; Dextran Sulfate; Dihydrostilbenoids; Humans; Macrophages; Male; Mice; Mice, Inbred C57BL; Tumor Microenvironment | 2020 |
Targeted Delivery of CXCL9 and OX40L by Mesenchymal Stem Cells Elicits Potent Antitumor Immunity.
Topics: Animals; Azoxymethane; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Chemokine CXCL9; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Immunotherapy, Adoptive; Killer Cells, Natural; Lymphocytes, Tumor-Infiltrating; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; OX40 Ligand; Transduction, Genetic; Transplantation, Isogeneic; Treatment Outcome; Tumor Microenvironment | 2020 |
Attenuation of Rat Colon Carcinogenesis by Styela plicata Aqueous Extract. Modulation of NF-κB Pathway and Cytoplasmic Sod1 Gene Expression.
Topics: Animals; Azoxymethane; Carcinogenesis; Carcinogens; Colonic Neoplasms; Cytoplasm; Gene Expression Regulation, Neoplastic; Male; NF-kappa B; Plant Extracts; Rats; Rats, Sprague-Dawley; Superoxide Dismutase-1; Urochordata | 2020 |
The chemopreventive effects of Huangqin-tea against AOM-induced preneoplastic colonic aberrant crypt foci in rats and omics analysis.
Topics: Aberrant Crypt Foci; Animals; Anticarcinogenic Agents; Azoxymethane; Colonic Neoplasms; Disease Models, Animal; Functional Food; Male; Rats; Rats, Wistar; Scutellaria baicalensis; Tea | 2020 |
Decorin deficiency promotes epithelial-mesenchymal transition and colon cancer metastasis.
Topics: Animals; Azoxymethane; beta Catenin; Cadherins; Cancer-Associated Fibroblasts; Celecoxib; Colitis-Associated Neoplasms; Colonic Neoplasms; Decorin; Epithelial-Mesenchymal Transition; Extracellular Matrix; Humans; Mice; Neoplasm Metastasis; Proteoglycans; Tumor Microenvironment | 2021 |
HLJ2 Effectively Ameliorates Colitis-Associated Cancer via Inhibition of NF-κB and Epithelial-Mesenchymal Transition.
Topics: Animals; Antineoplastic Agents, Phytogenic; Azoxymethane; Cell Line, Tumor; Colitis, Ulcerative; Colon; Colonic Neoplasms; Cytokines; Dextran Sulfate; Epithelial-Mesenchymal Transition; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Mice, Inbred C57BL; NF-kappa B; Transforming Growth Factor beta1 | 2020 |
Effects of combined treatment with Indomethacin and Juglone on AOM/DSS induced colon carcinogenesis in Balb/c mice: Roles of inflammation and apoptosis.
Topics: Animals; Apoptosis; Azoxymethane; Carcinogenesis; Cell Count; Cell Line, Tumor; Collagen; Colonic Neoplasms; Dextran Sulfate; Indomethacin; Inflammation; Male; Mast Cells; Mice, Inbred BALB C; Naphthoquinones | 2021 |
A thermogenic fat-epithelium cell axis regulates intestinal disease tolerance.
Topics: Adipocytes; Adipose Tissue, Brown; Animals; Azoxymethane; Cell Communication; Citrobacter rodentium; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Resistance; Enterobacteriaceae Infections; Epithelial Cells; Female; Humans; Intestinal Mucosa; Male; Mice; Neoplasms, Experimental; Thermogenesis | 2020 |
Inducible mouse models of colon cancer for the analysis of sporadic and inflammation-driven tumor progression and lymph node metastasis.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Disease Progression; Female; Inflammation; Lymphatic Metastasis; Male; Mice; Mice, Inbred C57BL | 2021 |
Vitamin E delta-tocotrienol and metabolite 13'-carboxychromanol inhibit colitis-associated colon tumorigenesis and modulate gut microbiota in mice.
Topics: Animals; Antineoplastic Agents; Azoxymethane; Benzopyrans; Carcinogenesis; Colitis; Colonic Neoplasms; Dextran Sulfate; Fatty Acids; Feces; Gastrointestinal Microbiome; Humans; Inflammation; Interleukin-1beta; Male; Mice; Mice, Inbred BALB C; RNA, Ribosomal, 16S; Vitamin E | 2021 |
Palmitoyl piperidinopiperidine, a novel derivative of 10‑hydroxy‑2‑decenoic acid, as a potent and selective anticancer agent against human colon carcinoma cell lines.
Topics: Animals; Antineoplastic Agents; Apoptosis; Azoxymethane; Carcinogens; Carcinoma; Cell Line, Tumor; Chick Embryo; Chorioallantoic Membrane; Colonic Neoplasms; Fatty Acids, Monounsaturated; Female; Humans; Inhibitory Concentration 50; Male; Mice; Molecular Docking Simulation; Neoplasms, Experimental; Neovascularization, Pathologic; Rats; Signal Transduction; STAT3 Transcription Factor; Xenograft Model Antitumor Assays | 2021 |
Zinc dyshomeostasis in azoxymethane-induced colonic precancerous and cancerous lesions in Fischer rats.
Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Male; Precancerous Conditions; Rats, Inbred F344; Zinc | 2021 |
Induction of colitis-associated neoplasia in mice using azoxymethane and dextran sodium sulfate.
Topics: Animals; Azoxymethane; Colitis; Colonic Neoplasms; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Mice; Mice, Inbred C57BL; Sulfates | 2021 |
Shinan Sea Salt Intake Ameliorates Colorectal Cancer in AOM/DSS with High Fat Diet-Induced C57BL/6N Mice.
Topics: Animals; Azoxymethane; Colitis; Colon; Colonic Neoplasms; Colorectal Neoplasms; Dextran Sulfate; Diet, High-Fat; Mice; Mice, Inbred C57BL; Republic of Korea; Sodium Chloride, Dietary | 2021 |
Inhibitory effects of a selective prostaglandin E2 receptor antagonist RQ-15986 on inflammation-related colon tumorigenesis in APC-mutant rats.
Topics: Adenomatous Polyposis Coli Protein; Animals; Azoxymethane; Benzamides; Carcinogenesis; Cell Proliferation; Chemokine CCL2; Colonic Neoplasms; Dextran Sulfate; Dinoprostone; Gene Expression Regulation, Neoplastic; Humans; Inflammation; Interleukin-18; Interleukin-6; Mutation; Rats; Receptors, Prostaglandin E, EP4 Subtype; Signal Transduction; Tumor Necrosis Factor-alpha | 2021 |
The immunomodulatory effects of topiramate on azoxymethane-induced colon carcinogenesis in rats: The role of the inflammatory cascade, vascular endothelial growth factor, AKT/mTOR/MAP kinase signaling and the apoptotic markers.
Topics: Animals; Apoptosis; Azoxymethane; Carcinogenesis; Colon; Colonic Neoplasms; Drug Screening Assays, Antitumor; Humans; Intestinal Mucosa; Male; MAP Kinase Signaling System; Neoplasms, Experimental; Proto-Oncogene Proteins c-akt; Rats; Topiramate; TOR Serine-Threonine Kinases; Tumor Microenvironment | 2021 |
Ganoderma lucidum polysaccharide modulates gut microbiota and immune cell function to inhibit inflammation and tumorigenesis in colon.
Topics: Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Azoxymethane; Carcinogenesis; Cell Line, Tumor; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Dysbiosis; Fungal Polysaccharides; Gastrointestinal Microbiome; Humans; Inflammation; Macrophage Activation; Male; Mice; Mice, Inbred C57BL; RAW 264.7 Cells; Reishi; Signal Transduction | 2021 |
Inhibitory Effect of Garcinol on Obesity-Exacerbated, Colitis-Mediated Colon Carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Biomarkers; Cell Proliferation; Colitis; Colonic Neoplasms; Cytokines; Dextran Sulfate; Diet, High-Fat; Disease Models, Animal; Dysbiosis; Gastrointestinal Microbiome; Gene Expression Regulation, Neoplastic; Lipids; Male; Mice, Inbred C57BL; Obesity; Organ Size; Proliferating Cell Nuclear Antigen; Terpenes | 2021 |
Proton Pump Inhibitor Omeprazole Suppresses Carcinogen-induced Colonic Adenoma Progression to Adenocarcinoma in F344 Rat.
Topics: Adenocarcinoma; Adenoma; Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Omeprazole; Proton Pump Inhibitors; Rats; Rats, Inbred F344 | 2021 |
Lack of STAT6 Attenuates Inflammation and Drives Protection against Early Steps of Colitis-Associated Colon Cancer.
Topics: Animals; Apoptosis; Azoxymethane; beta Catenin; Cell Proliferation; Colitis; Colon; Colonic Neoplasms; Cyclooxygenase 2; Cytokines; Dextran Sulfate; Female; Inflammation; Mice, Inbred BALB C; Mice, Knockout; RNA, Messenger; STAT6 Transcription Factor | 2017 |
Cysteinyl leukotriene receptor 1 facilitates tumorigenesis in a mouse model of colitis-associated colon cancer.
Topics: Animals; Azoxymethane; beta Catenin; Body Weight; Colitis; Colonic Neoplasms; Cyclooxygenase 2; Dextran Sulfate; Disease Models, Animal; Mice; Receptors, Leukotriene | 2017 |
Clostridium butyricum partially regulates the development of colitis-associated cancer through miR-200c.
Topics: Animals; Azoxymethane; Carcinogenesis; Cell Proliferation; Clostridium butyricum; Colitis; Colonic Neoplasms; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Humans; In Situ Hybridization, Fluorescence; Inflammation; Interleukin-12; Mice; MicroRNAs; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2017 |
Anthocyanins Prevent Colorectal Cancer Development in a Mouse Model.
Topics: Animals; Anthocyanins; Azoxymethane; Carcinoma in Situ; Colon; Colonic Neoplasms; Colonoscopy; Dextran Sulfate; Drug Screening Assays, Antitumor; Female; Mice, Inbred BALB C; Neoplasms, Experimental; Phytotherapy | 2017 |
Sphingosine kinase 1 expression enhances colon tumor growth.
Topics: Aged; Animals; Azoxymethane; Carcinogenesis; Cell Proliferation; Colonic Neoplasms; Cyclooxygenase 2; Enterocytes; Female; HT29 Cells; Humans; Male; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Neoplasm Staging; Phosphotransferases (Alcohol Group Acceptor) | 2017 |
Cooked Chickpea Consumption Inhibits Colon Carcinogenesis in Mice Induced with Azoxymethane and Dextran Sulfate Sodium.
Topics: Animals; Azoxymethane; beta Catenin; Cicer; Colonic Neoplasms; Cooking; Cyclooxygenase 2; Dextran Sulfate; Diet; Gene Expression Regulation; Ki-67 Antigen; Male; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Nitric Oxide Synthase Type II; Proliferating Cell Nuclear Antigen; Recommended Dietary Allowances | 2017 |
Fish Oil Contaminated with Persistent Organic Pollutants Induces Colonic Aberrant Crypt Foci Formation and Reduces Antioxidant Enzyme Gene Expression in Rats.
Topics: Animals; Antioxidants; Azoxymethane; Catalase; Cell Proliferation; Colon; Colonic Neoplasms; Dietary Supplements; Down-Regulation; Drug Contamination; Fish Oils; Fishes; Gene Expression; Intestinal Mucosa; Male; Pesticides; Polychlorinated Biphenyls; Rats, Sprague-Dawley; Superoxide Dismutase; Water Pollutants, Chemical | 2017 |
E-cadherin Mediates the Preventive Effect of Vitamin D3 in Colitis-associated Carcinogenesis.
Topics: Animals; Azoxymethane; beta Catenin; Cadherins; Carcinogenesis; Cell Proliferation; Cholecalciferol; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Up-Regulation; Vitamins | 2017 |
Role of intestinal microbiome in American ginseng-mediated colon cancer prevention in high fat diet-fed AOM/DSS mice [corrected].
Topics: Animals; Azoxymethane; Carcinogenesis; Colitis; Colonic Neoplasms; Dextran Sulfate; Diet, High-Fat; Gastrointestinal Microbiome; Male; Mice; Panax; Plant Extracts; Plant Roots | 2018 |
Inhibition of TRPM7 suppresses cell proliferation of colon adenocarcinoma in vitro and induces hypomagnesemia in vivo without affecting azoxymethane-induced early colon cancer in mice.
Topics: Acetates; Adenocarcinoma; Animals; Azoxymethane; Calcium; Cell Proliferation; Cells, Cultured; Colonic Neoplasms; Diterpenes; HT29 Cells; Humans; Intestinal Absorption; Magnesium Deficiency; Male; Mice; Mice, Inbred C57BL; TRPM Cation Channels | 2017 |
Anticarcinogenic activity of Muntingia calabura leaves methanol extract against the azoxymethane-induced colon cancer in rats involved modulation of the colonic antioxidant system partly by flavonoids.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Azoxymethane; Colon; Colonic Neoplasms; Elaeocarpaceae; Flavonoids; Male; Methanol; Plant Extracts; Plant Leaves; Rats; Rats, Sprague-Dawley | 2017 |
Dietary Phenethyl Isothiocyanate Protects Mice from Colitis Associated Colon Cancer.
Topics: Animals; Azoxymethane; Blotting, Western; Cell Survival; Chromatin Immunoprecipitation; Colitis; Colonic Neoplasms; Dextran Sulfate; Dietary Supplements; Humans; Isothiocyanates; Male; Mice; Mice, Inbred C57BL; NF-kappa B; RAW 264.7 Cells | 2017 |
Dietary Peptides from Phaseolus vulgaris L. Reduced AOM/DSS-Induced Colitis-Associated Colon Carcinogenesis in Balb/c Mice.
Topics: Animals; Azoxymethane; Colitis; Colonic Neoplasms; Dextran Sulfate; Dietary Proteins; Mice, Inbred BALB C; Phaseolus; Plant Extracts | 2017 |
Enhancing miR-132 expression by aryl hydrocarbon receptor attenuates tumorigenesis associated with chronic colitis.
Topics: Acetylcholinesterase; Animals; Azoxymethane; Carcinogenesis; Cell Movement; Cells, Cultured; Colitis, Ulcerative; Colon; Colonic Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; Female; Gene Expression Regulation, Neoplastic; Humans; Inflammation Mediators; Macrophages; Mice; Mice, Inbred C57BL; MicroRNAs; Polychlorinated Dibenzodioxins; Receptors, Aryl Hydrocarbon; RNA, Small Interfering | 2017 |
IL-17A-Induced PLET1 Expression Contributes to Tissue Repair and Colon Tumorigenesis.
Topics: Animals; Azoxymethane; Carcinogenesis; Cells, Cultured; Clustered Regularly Interspaced Short Palindromic Repeats; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Epithelial Cells; Gene Expression Regulation, Neoplastic; Interleukin-17; Mice; Mice, Inbred C57BL; Mice, Knockout; Pregnancy Proteins; Receptors, Interleukin; Wound Healing | 2017 |
Small molecules related to adrenomedullin reduce tumor burden in a mouse model of colitis-associated colon cancer.
Topics: Adrenomedullin; Animals; Antineoplastic Agents; Azoxymethane; Cluster Analysis; Colitis; Colon; Colonic Neoplasms; Disease Models, Animal; Disease Progression; Gastrointestinal Agents; Mice | 2017 |
RvD1 inhibits TNFα-induced c-Myc expression in normal intestinal epithelial cells and destabilizes hyper-expressed c-Myc in colon cancer cells.
Topics: Adaptor Proteins, Signal Transducing; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Azoxymethane; Carcinogens; Colonic Neoplasms; DNA-Binding Proteins; Docosahexaenoic Acids; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Mice; Mice, Inbred C57BL; NF-kappa B; Phosphorylation; Proteasome Endopeptidase Complex; Proteolysis; Receptors, Formyl Peptide; Receptors, Lipoxin; Signal Transduction; Transcription Factors; Tumor Necrosis Factor-alpha; Ubiquitination | 2018 |
Loss of FFAR2 promotes colon cancer by epigenetic dysregulation of inflammation suppressors.
Topics: Adenocarcinoma; Adenoma; Animals; Azoxymethane; Colitis; Colonic Neoplasms; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Dextran Sulfate; Disease Progression; Epigenesis, Genetic; Histone Deacetylases; Homeostasis; Inflammation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neoplasms, Experimental; Neutrophils; Receptors, G-Protein-Coupled | 2018 |
DNA methylome and transcriptome alterations and cancer prevention by curcumin in colitis-accelerated colon cancer in mice.
Topics: Animals; Azoxymethane; Colitis; Colon; Colonic Neoplasms; Curcumin; Dextran Sulfate; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Inflammation; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Transcriptome | 2018 |
Hydroquinone Exhibits In Vitro and In Vivo Anti-Cancer Activity in Cancer Cells and Mice.
Topics: Animals; Antineoplastic Agents; Azoxymethane; Benzoquinones; Cell Line, Tumor; Cell Proliferation; Cell Shape; Chickens; Colonic Neoplasms; Dextran Sulfate; Hydroquinones; Inhibitory Concentration 50; Lung Neoplasms; Male; Melanoma, Experimental; Mice, Inbred C57BL | 2018 |
1-L-MT, an IDO inhibitor, prevented colitis-associated cancer by inducing CDC20 inhibition-mediated mitotic death of colon cancer cells.
Topics: Animals; Apoptosis; Azoxymethane; Carcinogens; Cdc20 Proteins; Cell Cycle; Cell Proliferation; Colitis; Colonic Neoplasms; Enzyme Inhibitors; Homeodomain Proteins; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitosis; Tryptophan; Tumor Cells, Cultured | 2018 |
Pristimerin, a naturally occurring triterpenoid, attenuates tumorigenesis in experimental colitis-associated colon cancer.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Apoptosis; Azoxymethane; Cell Cycle; Cell Proliferation; Colitis; Colonic Neoplasms; Cytokines; Dextran Sulfate; Female; Forkhead Box Protein O3; Mice, Inbred BALB C; NF-kappa B; Pentacyclic Triterpenes; Proto-Oncogene Proteins c-akt; Triterpenes | 2018 |
Dietary fat and fiber interact to uniquely modify global histone post-translational epigenetic programming in a rat colon cancer progression model.
Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Dietary Fats; Dietary Fiber; Disease Models, Animal; Epigenesis, Genetic; Fish Oils; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; High-Throughput Nucleotide Sequencing; Histones; Male; Rats; Rats, Sprague-Dawley | 2018 |
More Protection of Lactobacillus acidophilus Than Bifidobacterium bifidum Probiotics on Azoxymethane-Induced Mouse Colon Cancer.
Topics: Animals; Azoxymethane; Bifidobacterium bifidum; Colonic Neoplasms; Humans; Interferon-gamma; Interleukin-10; Lactobacillus acidophilus; Male; Mice; Mice, Inbred BALB C; Probiotics | 2019 |
Microsatellite Instability in Mouse Models of Colorectal Cancer.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoxymethane; Colon; Colonic Neoplasms; Disease Models, Animal; Mice; Mice, Knockout; Microsatellite Instability; Microsatellite Repeats; MutS Homolog 2 Protein; Sulindac; Tumor Suppressor Protein p53 | 2018 |
Prolyl hydroxylase 2 is dispensable for homeostasis of intestinal epithelium in mice.
Topics: Animals; Azoxymethane; Cell Line; Cell Line, Tumor; Colitis; Colonic Neoplasms; Dextran Sulfate; Epithelial Cells; Homeostasis; Humans; Hypoxia-Inducible Factor-Proline Dioxygenases; Intestinal Mucosa; Mice, Knockout; Mice, Transgenic | 2018 |
Parabacteroides distasonis attenuates toll-like receptor 4 signaling and Akt activation and blocks colon tumor formation in high-fat diet-fed azoxymethane-treated mice.
Topics: Animals; Apoptosis; Azoxymethane; Bacteroidetes; Carcinogens; Cell Proliferation; Colonic Neoplasms; Diet, High-Fat; Humans; Male; Mice; Mice, Inbred A; Proto-Oncogene Proteins c-akt; Toll-Like Receptor 4; Tumor Cells, Cultured | 2018 |
Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice.
Topics: Animals; Azoxymethane; Bifidobacterium; Colitis; Colon; Colonic Neoplasms; Cytokines; Disease Models, Animal; Gastrointestinal Microbiome; Humans; Intestinal Mucosa; Lacticaseibacillus rhamnosus; Lactobacillus acidophilus; Male; Mice; Mice, Inbred C57BL; Probiotics; RNA, Ribosomal, 16S | 2018 |
A Novel Modification of the AOM/DSS Model for Inducing Intestinal Adenomas in Mice.
Topics: Adenoma; Animals; Azoxymethane; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Female; Humans; Intestinal Neoplasms; Mice, Inbred C57BL | 2018 |
Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses.
Topics: Animals; Azoxymethane; Carcinogenesis; Colitis, Ulcerative; Colon; Colonic Neoplasms; Cytokines; Dextran Sulfate; Inflammation; Macrophage Activation; Macrophages; Male; Mice; Ornithine Decarboxylase; Transcription, Genetic; Up-Regulation | 2018 |
Pharmacological activation of epidermal growth factor receptor signaling inhibits colitis-associated cancer in mice.
Topics: Animals; Azoxymethane; Colitis; Colonic Neoplasms; Dextran Sulfate; Epidermal Growth Factor; ErbB Receptors; Mice; Neoplasm Proteins; Neoplasms, Experimental; Signal Transduction | 2018 |
Transcriptomics analysis reveals new insights in E171-induced molecular alterations in a mouse model of colon cancer.
Topics: Animals; Antioxidants; Azoxymethane; Colonic Neoplasms; Dextran Sulfate; Female; Male; Mice; Mice, Inbred BALB C; Oxidative Stress; RNA, Messenger; Transcriptome; Xenobiotics | 2018 |
Geminin ablation in vivo enhances tumorigenesis through increased genomic instability.
Topics: Adenoma; Animals; Ataxia Telangiectasia Mutated Proteins; Azoxymethane; Carcinoma; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Geminin; Genes, Tumor Suppressor; Genetic Predisposition to Disease; Genomic Instability; Histones; Lung Neoplasms; Mice, Inbred C57BL; Mice, Knockout; Phenotype; Phosphorylation; Urethane | 2018 |
Deleting MyD88 signaling in myeloid cells promotes development of adenocarcinomas of the colon.
Topics: Adenocarcinoma; Animals; Azoxymethane; beta Catenin; Colonic Neoplasms; Cytokines; Dextran Sulfate; DNA Damage; Gene Knockout Techniques; Humans; Mice; Mutation; Myeloid Cells; Myeloid Differentiation Factor 88; Signal Transduction; Tumor Burden | 2018 |
The Rac1 splice form Rac1b favors mouse colonic mucosa regeneration and contributes to intestinal cancer progression.
Topics: Animals; Azoxymethane; Carcinogenesis; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Disease Progression; Epithelial Cells; Inflammation; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Neuropeptides; rac1 GTP-Binding Protein; Signal Transduction | 2018 |
Cannabinoid Receptor-1 Up-regulation in Azoxymethane (AOM)-treated Mice After Dietary Treatment with Quercetin.
Topics: Animals; Apoptosis; Azoxymethane; bcl-2-Associated X Protein; Carcinogenesis; Cell Proliferation; Colonic Neoplasms; Diet; Dietary Supplements; Flavonoids; Gene Expression; Male; Mice; Mice, Inbred C57BL; Proto-Oncogene Proteins c-bcl-2; Quercetin; Receptor, Cannabinoid, CB1; Up-Regulation | 2018 |
Fermented Ganjangs (Soy Sauce and Sesame Sauce) Attenuates Colonic Carcinogenesis in Azoxymethane/Dextran Sodium Sulfate-Treated C57BL/6J Mice.
Topics: Animals; Azoxymethane; Carcinogenesis; Colon; Colonic Neoplasms; Cyclooxygenase 2; Dextran Sulfate; Fermentation; Humans; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; Sesamum; Soy Foods; Tumor Necrosis Factor-alpha | 2018 |
Early increase in blood supply (EIBS) is associated with tumor risk in the Azoxymethane model of colon cancer.
Topics: Animals; Azoxymethane; Blood Vessels; Carcinogenesis; Colon; Colonic Neoplasms; Dextrans; Disease Models, Animal; Fluorescein-5-isothiocyanate; Hemoglobins; Humans; Mice; Microscopy, Confocal; Renin-Angiotensin System | 2018 |
DNA damage response genes mark the early transition from colitis to neoplasia in colitis-associated colon cancer.
Topics: Animals; Azoxymethane; Carcinogenesis; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Disease Progression; DNA Damage; Gene Expression Regulation; Inflammation; Inflammatory Bowel Diseases; Intestines; Male; Mice; Mice, Inbred C57BL; Microsatellite Instability; Signal Transduction | 2018 |
Comprehensive analysis of differential circular RNA expression in a mouse model of colitis-induced colon carcinoma.
Topics: Animals; Azoxymethane; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; MAP Kinase Signaling System; Mice; MicroRNAs; RNA; RNA, Circular | 2018 |
Effects of Dietary Fibre from the Traditional Indonesian Food, Green Cincau (
Topics: Animals; Azoxymethane; Cells, Cultured; Colon; Colonic Neoplasms; Dietary Fiber; Fatty Acids, Volatile; Gastrointestinal Microbiome; Lamiaceae; Lipid Peroxidation; Male; Rats; Rats, Sprague-Dawley | 2018 |
Matricellular protein periostin promotes colitis-associated colon tumorigenesis in mice.
Topics: Animals; Apoptosis; Azoxymethane; Caspase 3; Cell Adhesion Molecules; Colitis; Colonic Neoplasms; Cyclooxygenase 2; Cytokines; HCT116 Cells; Humans; Male; Mice; Mice, Inbred C57BL; NF-kappa B | 2019 |
Protective Effect of Chickpea Protein Hydrolysates on Colon Carcinogenesis Associated With a Hypercaloric Diet.
Topics: Animals; Azoxymethane; Carcinogenesis; Cicer; Colon; Colonic Neoplasms; Diet; Disease Models, Animal; Energy Intake; Male; Mice; Protective Agents; Protein Hydrolysates; Seeds | 2019 |
The phosphatidic acid phosphatase lipin-1 facilitates inflammation-driven colon carcinogenesis.
Topics: Animals; Azoxymethane; Carcinogenesis; Cell Proliferation; Chemokine CXCL1; Chemokine CXCL2; Colitis; Colon; Colonic Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; Female; Humans; Inflammation; Inflammatory Bowel Diseases; Interleukin-23; Macrophages; Mice; Mice, Inbred BALB C; Mucous Membrane; Nuclear Proteins; Phosphatidate Phosphatase | 2018 |
Establishment of a multicomponent dietary bioactive human equivalent dose to delete damaged Lgr5+ stem cells using a mouse colon tumor initiation model.
Topics: Animals; Apoptosis; Azoxymethane; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Curcumin; Dietary Supplements; Dose-Response Relationship, Drug; Fatty Acids, Omega-3; Female; Gene Knock-In Techniques; Humans; Intestinal Mucosa; Male; Mice; Mice, Transgenic; Neoplasms, Experimental; Neoplastic Stem Cells; Receptors, G-Protein-Coupled | 2019 |
Generation of and characterization of anti-IL-11 antibodies using newly established Il11-deficient mice.
Topics: Animals; Antibodies; Azoxymethane; Carcinogens; Cell Proliferation; Colonic Neoplasms; Dextran Sulfate; Interleukin-11; Interleukin-6; Mice; Mice, Knockout; Phosphorylation; STAT3 Transcription Factor; Stromal Cells | 2018 |
A mixture of Persistent Organic Pollutants (POPs) and Azoxymethane (AOM) show potential synergistic effects on intestinal tumorigenesis in the A/J Min/+ mouse model.
Topics: Animals; Azoxymethane; Carcinogenesis; Carcinogens; Colonic Neoplasms; Diet; Disease Models, Animal; Drug Synergism; Environmental Pollutants; Female; Intestines; Liver; Male; Mice; Mice, Inbred A; Organic Chemicals | 2019 |
Chemopreventive Effects of Whole Cranberry (Vaccinium macrocarpon) on Colitis-Associated Colon Tumorigenesis.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Cell Proliferation; Colitis; Colonic Neoplasms; Cyclooxygenase 2; Cytokines; Dextran Sulfate; Enzymes; Male; Mice, Inbred Strains; Neovascularization, Pathologic; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Vaccinium macrocarpon | 2018 |
Folate/Vitamin B12 Supplementation Combats Oxidative Stress-Associated Carcinogenesis in a Rat Model of Colon Cancer.
Topics: Animals; Azoxymethane; Carcinogenesis; Colonic Neoplasms; Dietary Supplements; Disease Models, Animal; Folic Acid; Glutathione; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Vitamin B 12 | 2019 |
Tucum-do-cerrado (Bactris setosa Mart.) modulates oxidative stress, inflammation, and apoptosis-related proteins in rats treated with azoxymethane.
Topics: Animals; Apoptosis; Arecaceae; Azoxymethane; Colon; Colonic Neoplasms; Disease Models, Animal; Fruit; Inflammation; Liver; Male; Oxidative Stress; Phytotherapy; Rats, Wistar | 2018 |
Antibiotics suppress colon tumorigenesis through inhibition of aberrant DNA methylation in an azoxymethane and dextran sulfate sodium colitis model.
Topics: Animals; Anti-Bacterial Agents; Azoxymethane; Cell Transformation, Neoplastic; Colitis, Ulcerative; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; DNA Methylation; Gastrointestinal Microbiome; Humans; Intestinal Mucosa; Male; Mice, Inbred BALB C | 2019 |
Therapeutic effects of lentinan on inflammatory bowel disease and colitis-associated cancer.
Topics: Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Azoxymethane; Carcinoembryonic Antigen; CD30 Ligand; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Female; Gastrointestinal Microbiome; Gene Expression Regulation, Neoplastic; Hyperplasia; Interleukin-13; Keratin-18; Keratin-8; Lentinan; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; NF-kappa B; Signal Transduction; Sulfasalazine; Toll-Like Receptor 4; Tumor Suppressor Protein p53 | 2019 |
Chemopreventive Effects of Silibinin on Colitis-Associated Tumorigenesis by Inhibiting IL-6/STAT3 Signaling Pathway.
Topics: Animals; Azoxymethane; Blotting, Western; Colitis; Colonic Neoplasms; Dextran Sulfate; Female; HCT116 Cells; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Interleukin-6; Mice; Mice, Inbred C57BL; Real-Time Polymerase Chain Reaction; Silybin; STAT3 Transcription Factor | 2018 |
Effects of obesity and exercise on colon cancer induction and hematopoiesis in mice.
Topics: Adipose Tissue; Animals; Azoxymethane; Bone Marrow; Carcinogens; Colonic Neoplasms; Diet, High-Fat; Hematopoiesis; Hematopoietic Stem Cells; Inflammation; Mice; Myeloid Progenitor Cells; Neoplasms, Experimental; Obesity; Physical Conditioning, Animal; Proteomics; Random Allocation; Sedentary Behavior | 2019 |
Tenascin-C Produced by Intestinal Myofibroblasts Promotes Colitis-associated Cancer Development Through Angiogenesis.
Topics: Animals; Azoxymethane; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Dextran Sulfate; Gene Expression Profiling; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Myofibroblasts; Neovascularization, Pathologic; Tenascin | 2019 |
Intermittent hypoxia promotes carcinogenesis in azoxymethane and dextran sodium sulfate-induced colon cancer model.
Topics: Animals; Azoxymethane; Carcinogenesis; Carcinogens; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Hypoxia; Inflammation; Male; Mice; Mice, Inbred C57BL; Oxidative Stress | 2019 |
Identification of epithelial-specific ETS-1 (ESE-1) as a tumor suppressor and molecular target of green tea compound, EGCG.
Topics: Animals; Antineoplastic Agents, Phytogenic; Azoxymethane; Caco-2 Cells; Catechin; Cell Line, Tumor; Cell Movement; Cell Nucleus; Colonic Neoplasms; Dextran Sulfate; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; HCT116 Cells; HT29 Cells; Humans; Mice; Nuclear Localization Signals; Proto-Oncogene Proteins c-ets; Transcription Factors; Xenograft Model Antitumor Assays | 2019 |
Silibinin Retards Colitis-associated Carcinogenesis by Repression of Cdc25C in Mouse Model.
Topics: Animals; Antineoplastic Agents, Phytogenic; Azoxymethane; Carcinogenesis; Carcinogens; cdc25 Phosphatases; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Male; Mice; Mice, Inbred C57BL; Silybin | 2019 |
Impact of 5 fluorouracil chemotherapy on gut inflammation, functional parameters, and gut microbiota.
Topics: Animals; Azoxymethane; Colitis; Colon; Colonic Neoplasms; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Fecal Microbiota Transplantation; Fluorouracil; Gastrointestinal Microbiome; Inflammation; Male; Mice; Mice, Inbred C57BL | 2019 |
A novel mouse model of sporadic colon cancer induced by combination of conditional Apc genes and chemical carcinogen in the absence of Cre recombinase.
Topics: Adenocarcinoma; Adenoma; Animals; Azoxymethane; Carcinogenesis; Carcinogens; Colonic Neoplasms; Disease Models, Animal; Genes, APC; Integrases; Mice; Mice, Inbred C57BL | 2019 |
Chemopreventive Activity of Red Ginseng Oil in a Mouse Model of Azoxymethane/Dextran Sulfate Sodium-Induced Inflammation-Associated Colon Carcinogenesis.
Topics: Animals; Azoxymethane; Colitis; Colon; Colonic Neoplasms; Cyclooxygenase 2; Dextran Sulfate; Disease Models, Animal; Humans; Interleukin-1beta; Male; Mice; Mice, Inbred C57BL; Panax; Plant Extracts; Tumor Necrosis Factor-alpha | 2019 |
IL-21 Enhances the Development of Colitis-Associated Colon Cancer: Possible Involvement of Activation-Induced Cytidine Deaminase Expression.
Topics: Animals; Azoxymethane; B-Lymphocytes; Cell Line, Tumor; Colitis; Colonic Neoplasms; Cytidine Deaminase; Dextran Sulfate; Disease Models, Animal; Humans; Immunoglobulin Class Switching; Inflammatory Bowel Diseases; Interleukins; Intestinal Mucosa; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mice, Transgenic | 2019 |
Oct1/Pou2f1 is selectively required for colon regeneration and regulates colon malignancy.
Topics: Animals; Azoxymethane; Carcinogenesis; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Integrases; Intestine, Small; Mice; Mice, Knockout; Neoplastic Stem Cells; Octamer Transcription Factor-1; Organoids; Receptors, G-Protein-Coupled; Regeneration; Signal Transduction; Survival Analysis; Tamoxifen | 2019 |
Platelet Depletion/Transfusion as a Lethal Factor in a Colitis-associated Cancer Mouse Model.
Topics: Animals; Azoxymethane; Blood Platelets; Carcinogenesis; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Humans; Mice; Mice, Knockout; Platelet Transfusion; Toll-Like Receptor 4 | 2019 |
Regulation of tumor angiogenesis and mesenchymal-endothelial transition by p38α through TGF-β and JNK signaling.
Topics: Animals; Azoxymethane; Carcinogens; Cell Proliferation; Cell Transdifferentiation; Colonic Neoplasms; Endothelial Cells; Endothelium, Vascular; Epithelial-Mesenchymal Transition; Gene Knockdown Techniques; HT29 Cells; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitogen-Activated Protein Kinase 14; Neoplasms, Experimental; Neovascularization, Pathologic; RNA, Small Interfering; Transforming Growth Factor beta | 2019 |
Induction of endoplasmic reticulum stress and inhibition of colon carcinogenesis by the anti-helmintic drug rafoxanide.
Topics: Aged; Animals; Antinematodal Agents; Apoptosis; Azoxymethane; Carcinogens; Cell Proliferation; Colonic Neoplasms; Colorectal Neoplasms; Endoplasmic Reticulum Stress; Female; Humans; Male; Mice; Rafoxanide; Tumor Cells, Cultured | 2019 |
Oestrogens promote tumorigenesis in a mouse model for colitis-associated cancer.
Topics: Animals; Azoxymethane; Carcinogenesis; Colitis; Colonic Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; Estradiol; Estrogens; Female; Hormone Replacement Therapy; Immunohistochemistry; Medroxyprogesterone; Mice; Ovariectomy | 2014 |
Biological mechanisms underlying structural changes induced by colorectal field carcinogenesis measured with low-coherence enhanced backscattering (LEBS) spectroscopy.
Topics: Adenoma; Animals; Azoxymethane; Cluster Analysis; Colchicine; Colonic Neoplasms; Cytoskeleton; Intestinal Mucosa; Light; Rats; Rats, Inbred F344; Rectum; Scattering, Radiation; Spectrophotometry; Transcriptome; Tubulin Modulators | 2013 |
Diet induced obesity increases the risk of colonic tumorigenesis in mice.
Topics: Aberrant Crypt Foci; Analysis of Variance; Animals; Azoxymethane; Body Weight; Carcinogenesis; Carcinogens; Colonic Neoplasms; Energy Intake; Male; Mice; Mice, Inbred C57BL; Obesity; Random Allocation; Weight Gain | 2013 |
Targeted deletion of the metastasis-associated phosphatase Ptp4a3 (PRL-3) suppresses murine colon cancer.
Topics: Animals; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Dextran Sulfate; Gene Deletion; Humans; Immediate-Early Proteins; Intestinal Mucosa; Mice; Mice, Knockout; Neoplasm Metastasis; Neoplasms, Experimental; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-myc | 2013 |
Diet-induced obesity promotes colon tumor development in azoxymethane-treated mice.
Topics: Aberrant Crypt Foci; Adenoma; Animals; Azoxymethane; Colon; Colonic Neoplasms; Diet, High-Fat; Interferon-gamma; Interleukin-1beta; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Obesity; Risk Factors; Tumor Necrosis Factor-alpha | 2013 |
Altered gut microbiota promotes colitis-associated cancer in IL-1 receptor-associated kinase M-deficient mice.
Topics: Animals; Azoxymethane; Blotting, Western; Carcinogens; Colitis; Colonic Neoplasms; Cytokines; Dextran Sulfate; Female; Flow Cytometry; Gastrointestinal Tract; Interleukin-1 Receptor-Associated Kinases; Male; Metagenome; Mice; Mice, Inbred C57BL; Mice, Knockout; Real-Time Polymerase Chain Reaction; Receptors, Interleukin-1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; T-Lymphocytes, Regulatory; Toll-Like Receptors | 2013 |
RNase-L deficiency exacerbates experimental colitis and colitis-associated cancer.
Topics: Animals; Azoxymethane; Blotting, Western; Carcinogens; Colitis; Colonic Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; Endoribonucleases; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Immunity, Innate; Immunoenzyme Techniques; Interferon Type I; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Peroxidase; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction | 2013 |
Vitamin D receptor and retinoid X receptor α status and vitamin D insufficiency in models of murine colitis.
Topics: Acute Disease; Animals; Azoxymethane; Blotting, Western; Carcinogens; Cell Proliferation; Chronic Disease; Colitis; Colonic Neoplasms; Dextran Sulfate; Diet; Female; Immunoenzyme Techniques; Mice; Mice, Inbred C57BL; Real-Time Polymerase Chain Reaction; Receptors, Calcitriol; Retinoid X Receptor alpha; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Snail Family Transcription Factors; Transcription Factors; Vitamin D Deficiency | 2013 |
Cholinergic muscarinic receptor activation augments murine intestinal epithelial cell proliferation and tumorigenesis.
Topics: Adenocarcinoma; Animals; Azoxymethane; Bethanechol; Cell Proliferation; Cell Transformation, Neoplastic; Colonic Neoplasms; Cyclin D1; Cyclooxygenase 2; ErbB Receptors; Gene Expression; Hypoxia-Inducible Factor 1, alpha Subunit; Intestinal Mucosa; Male; Matrix Metalloproteinase 10; Matrix Metalloproteinase 13; Matrix Metalloproteinase 7; Mice; Muscarinic Agonists; Proto-Oncogene Proteins c-myc; Receptor, Muscarinic M3; RNA, Messenger; Signal Transduction; Tumor Burden | 2013 |
Grape seed extract efficacy against azoxymethane-induced colon tumorigenesis in A/J mice: interlinking miRNA with cytokine signaling and inflammation.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Azoxymethane; beta Catenin; Biomarkers, Tumor; Blotting, Western; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; Colonic Neoplasms; Cytokines; Extracellular Signal-Regulated MAP Kinases; Gene Expression Profiling; Grape Seed Extract; Immunoenzyme Techniques; Inflammation; Male; Mice; Mice, Inbred A; MicroRNAs; Mitogen-Activated Protein Kinases; NF-kappa B; Oligonucleotide Array Sequence Analysis; Phosphorylation; Signal Transduction | 2013 |
IDO1 metabolites activate β-catenin signaling to promote cancer cell proliferation and colon tumorigenesis in mice.
Topics: Animals; Azoxymethane; beta Catenin; Carcinogens; Cell Proliferation; Colitis; Colitis, Ulcerative; Colonic Neoplasms; Epithelial Cells; HCT116 Cells; Homeodomain Proteins; HT29 Cells; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Intestinal Mucosa; Kynurenine; Mice; Mice, Inbred C57BL; Mice, Knockout; Quinolinic Acid; Signal Transduction | 2013 |
Prevention of familial adenomatous polyp development in APC min mice and azoxymethane-induced colon carcinogenesis in F344 Rats by ω-3 fatty acid rich perilla oil.
Topics: Aberrant Crypt Foci; Adenomatous Polyposis Coli; alpha-Linolenic Acid; Animals; Anticarcinogenic Agents; Azoxymethane; Carcinogenesis; Colonic Neoplasms; Corn Oil; Cyclooxygenase 1; Cyclooxygenase 2; Dose-Response Relationship, Drug; Female; Intestinal Mucosa; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Plant Oils; Rats; Rats, Inbred F344 | 2013 |
A novel shift in estrogen receptor expression occurs as estradiol suppresses inflammation-associated colon tumor formation.
Topics: Animals; Antineoplastic Agents; Azoxymethane; Colonic Neoplasms; Dextran Sulfate; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens; Female; Inflammation; Mice; Mice, Inbred C57BL; Mice, Knockout | 2013 |
Chemopreventive effects of PBI-Se, a selenium-containing analog of PBIT, on AOM-induced aberrant crypt foci in F344 rats.
Topics: Aberrant Crypt Foci; Animals; Apoptosis; Azoxymethane; Caco-2 Cells; Cell Line, Tumor; Cell Proliferation; Chemoprevention; Colonic Neoplasms; Cyclin D1; Humans; Interleukin-6; Interleukin-8; Male; Nitric Oxide Synthase Type II; Rats; Rats, Inbred F344; Selenium Compounds; Thiourea | 2013 |
Methanolic extract of white asparagus shoots activates TRAIL apoptotic death pathway in human cancer cells and inhibits colon carcinogenesis in a preclinical model.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Asparagus Plant; Azoxymethane; Carcinogenesis; Caspase 3; Caspase 8; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Enzyme Activation; Humans; Intestinal Mucosa; Male; Methanol; Plant Extracts; Plant Shoots; Rats; Rats, Wistar; TNF-Related Apoptosis-Inducing Ligand | 2013 |
Raman endoscopy for the in situ investigation of advancing colorectal tumors in live model mice.
Topics: Age Factors; Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Disease Progression; Mice; Mice, Inbred BALB C; Spectrum Analysis, Raman | 2013 |
Grape seeds: ripe for cancer chemoprevention.
Topics: Animals; Antineoplastic Agents, Phytogenic; Azoxymethane; Cell Transformation, Neoplastic; Colonic Neoplasms; Grape Seed Extract; Male; MicroRNAs; Signal Transduction | 2013 |
Targeting epigenetics for cancer prevention by dietary cancer preventive compounds--the case of miRNA.
Topics: Animals; Antineoplastic Agents, Phytogenic; Azoxymethane; Cell Transformation, Neoplastic; Colonic Neoplasms; Grape Seed Extract; Male; MicroRNAs; Signal Transduction | 2013 |
Suppression of β-catenin and cyclooxygenase-2 expression and cell proliferation in azoxymethane-induced colonic cancer in rats by rice bran phytic acid (PA).
Topics: Adenoma; Animals; Apoptosis; Azoxymethane; beta Catenin; Blotting, Western; Carcinogens; Cell Proliferation; Colonic Neoplasms; Cyclooxygenase 2; Immunoenzyme Techniques; Male; Oryza; Phytic Acid; Rats; Rats, Sprague-Dawley | 2013 |
Intestine-Specific Mttp Deletion Increases the Severity of Experimental Colitis and Leads to Greater Tumor Burden in a Model of Colitis Associated Cancer.
Topics: Animals; Azoxymethane; Carrier Proteins; Cells, Cultured; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Feces; Interleukin-17; Interleukin-1beta; Intestines; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myofibroblasts; Severity of Illness Index; Tumor Burden; Tumor Necrosis Factor-alpha | 2013 |
Risk of colonic cancer is not higher in the obese Lep(ob) mouse model compared to lean littermates.
Topics: Aberrant Crypt Foci; Analysis of Variance; Animals; Azoxymethane; Colonic Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Random Allocation | 2013 |
Oroxylin A inhibits colitis-associated carcinogenesis through modulating the IL-6/STAT3 signaling pathway.
Topics: Animals; Azoxymethane; Blotting, Western; Carcinogens; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Dextran Sulfate; Female; Flavonoids; Fluorescent Antibody Technique; Humans; Immunoenzyme Techniques; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; STAT3 Transcription Factor | 2013 |
The 5-aminosalicylic acid antineoplastic effect in the intestine is mediated by PPARγ.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Azoxymethane; Blotting, Western; Cell Proliferation; Colonic Neoplasms; Humans; Immunoenzyme Techniques; Intestinal Mucosa; Intestines; Male; Mesalamine; Mice; Mice, Inbred A; Mice, Inbred BALB C; Mice, SCID; PPAR gamma; Tumor Cells, Cultured | 2013 |
Dietary selenium deficiency exacerbates DSS-induced epithelial injury and AOM/DSS-induced tumorigenesis.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Azoxymethane; Carcinogenesis; Colitis; Colonic Neoplasms; Deoxyguanosine; Dextran Sulfate; Diet; DNA Damage; Epidermal Growth Factor; Gene Expression Regulation; Inflammation; Mice; Mice, Inbred C57BL; Selenium; Signal Transduction; Transforming Growth Factor beta; Weight Loss | 2013 |
Downregulation of hematopoietic MUC1 during experimental colitis increases tumor-promoting myeloid-derived suppressor cells.
Topics: Animals; Azoxymethane; Biomarkers, Tumor; Blotting, Western; Bone Marrow Transplantation; Carcinogens; Colitis, Ulcerative; Colonic Neoplasms; Crohn Disease; Female; Flow Cytometry; Gene Expression Profiling; Humans; Immunoenzyme Techniques; Mice; Mice, Knockout; Mucin-1; Myeloid Cells; Oligonucleotide Array Sequence Analysis; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2013 |
Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancer.
Topics: Animals; Apoptosis; Axl Receptor Tyrosine Kinase; Azoxymethane; c-Mer Tyrosine Kinase; Colitis; Colon; Colonic Neoplasms; Cytokines; Dextran Sulfate; Female; Flow Cytometry; Gene Expression; Macrophages; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Mucous Membrane; Neutrophils; Phagocytosis; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction | 2013 |
Flaxseed (Linum usitatissimum L.) and its total non-digestible fraction influence the expression of genes involved in azoxymethane-induced colon cancer in rats.
Topics: Animals; Antioxidants; Apoptosis; Azoxymethane; Carcinogens; Cell Cycle Checkpoints; Colon; Colonic Neoplasms; Diet; Digestion; Flavonoids; Flax; Gene Expression; Male; Phenols; Phytotherapy; Rats; Rats, Sprague-Dawley; Seeds; Tannins | 2013 |
Sepiapterin ameliorates chemically induced murine colitis and azoxymethane-induced colon cancer.
Topics: Animals; Azoxymethane; Colitis; Colonic Neoplasms; Male; Mice; Mice, Inbred C57BL; Organ Culture Techniques; Pterins | 2013 |
Deletion of glutathione peroxidase-2 inhibits azoxymethane-induced colon cancer development.
Topics: Adenoma; Animals; Antioxidants; Apoptosis; Azoxymethane; beta Catenin; Carcinogenesis; Colonic Neoplasms; Diet; Dietary Supplements; Epithelial Cells; Gene Deletion; Glutathione Peroxidase; Humans; Intestinal Mucosa; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Precancerous Conditions; Proliferating Cell Nuclear Antigen; Selenium | 2013 |
Baicalein, an active component of Scutellaria baicalensis Georgi, induces apoptosis in human colon cancer cells and prevents AOM/DSS-induced colon cancer in mice.
Topics: Animals; Antioxidants; Apoptosis; Azoxymethane; Blotting, Western; Carcinogens; Cell Movement; Cell Proliferation; Colitis; Colonic Neoplasms; Dextran Sulfate; Flavanones; Humans; Male; Mice; Mice, Inbred ICR; NF-kappa B; Poly(ADP-ribose) Polymerases; Scutellaria baicalensis; Tumor Cells, Cultured | 2013 |
Over-expression of LGR5 correlates with poor survival of colon cancer in mice as well as in patients.
Topics: Adult; Aged; Aged, 80 and over; Animals; Azoxymethane; Biomarkers; Cell Proliferation; Colonic Neoplasms; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Male; Mice; Middle Aged; Neoplasm Staging; Neoplastic Stem Cells; Receptors, G-Protein-Coupled; Survival Analysis | 2014 |
Chemopreventive efficacy of raloxifene, bexarotene, and their combination on the progression of chemically induced colon adenomas to adenocarcinomas in rats.
Topics: Adenocarcinoma; Adenoma; Adult; Aged; Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Bexarotene; Biomarkers, Tumor; Blotting, Western; Colonic Neoplasms; Drug Therapy, Combination; Estrogen Antagonists; Estrogen Receptor beta; Female; Humans; Immunoenzyme Techniques; Male; Middle Aged; Neoplasm Grading; Raloxifene Hydrochloride; Rats; Rats, Inbred F344; Real-Time Polymerase Chain Reaction; Retinoid X Receptors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrahydronaphthalenes; Tissue Array Analysis; Tumor Cells, Cultured | 2013 |
Ponderal behavior of rats fed an omegas 3, 6 and 9 enriched diet submitted to colon carcinogenesis induced by azoxymethane.
Topics: Animals; Azoxymethane; Body Weight; Carcinogens; Colonic Neoplasms; Eating; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Fatty Acids, Unsaturated; Food, Fortified; Injections, Intraperitoneal; Male; Oleic Acids; Random Allocation; Rats, Wistar | 2013 |
Nabag (Zizyphus spina-christi) extract prevents aberrant crypt foci development in colons of azoxymethane-treated rats by abrogating oxidative stress and inducing apoptosis.
Topics: Aberrant Crypt Foci; Animals; Apoptosis; Azoxymethane; Carcinogens; Caspase 3; Colon; Colonic Neoplasms; Fruit; Glutathione; Male; Oxidative Stress; Plant Extracts; Rats; Rats, Sprague-Dawley; Ziziphus | 2013 |
Simultaneous follow-up of mouse colon lesions by colonoscopy and endoluminal ultrasound biomicroscopy.
Topics: Animals; Azoxymethane; Bronchoscopes; Colon; Colonic Neoplasms; Colonoscopes; Colonoscopy; Dextran Sulfate; Disease Progression; Endosonography; Equipment Design; Female; Genes, p53; Male; Mice; Mice, 129 Strain; Mice, Knockout; Microscopy, Acoustic; Miniaturization; Predictive Value of Tests; Time Factors | 2013 |
Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol.
Topics: Animals; Azoxymethane; Cannabidiol; Cannabinoid Receptor Antagonists; Cannabis; Carcinogenesis; Carcinoma; Cell Proliferation; Cell Survival; CHO Cells; Colonic Neoplasms; Cricetinae; Cricetulus; Epithelial Cells; HCT116 Cells; Humans; Male; Mice, Inbred ICR; Phytotherapy; Plant Extracts; Random Allocation; Receptors, Cannabinoid; Xenograft Model Antitumor Assays | 2014 |
Luteolin, a bioflavonoid, attenuates azoxymethane-induced effects on mitochondrial enzymes in BALB/c mice.
Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Animals; Azoxymethane; Blotting, Western; Carcinogens; Colon; Colonic Neoplasms; Electron Transport Complex I; Electron Transport Complex IV; Isocitrate Dehydrogenase; Luteolin; Male; Mice; Mice, Inbred BALB C; Mitochondria; Succinate Dehydrogenase | 2014 |
Increased preventive effect on colon carcinogenesis by use of resistant starch (RS3) as the carrier for polysaccharide of Larimichthys crocea swimming bladder.
Topics: Animals; Apoptosis Regulatory Proteins; Azoxymethane; Body Weight; Colonic Neoplasms; Cytokines; Dextran Sulfate; Down-Regulation; Gene Expression; Inflammation Mediators; Male; Mice; Mice, Inbred C57BL; Perciformes; Polysaccharides; Starch; Up-Regulation | 2014 |
Identification of a microRNA landscape targeting the PI3K/Akt signaling pathway in inflammation-induced colorectal carcinogenesis.
Topics: Animals; Azoxymethane; Carcinogenesis; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction | 2014 |
Azoxymethane-induced colon carcinogenesis in mice occurs independently of de novo thymidylate synthesis capacity.
Topics: Animals; Azoxymethane; Carcinogenesis; Choline Deficiency; Colon; Colonic Neoplasms; Crosses, Genetic; Disease Models, Animal; DNA; Extracellular Matrix Proteins; Folic Acid; Folic Acid Deficiency; Glycine Hydroxymethyltransferase; Male; Mice; Mice, Knockout; Mice, Transgenic; Neoplasm Proteins; Protein-Lysine 6-Oxidase; Random Allocation; Thymidine Monophosphate; Tumor Burden; Uracil | 2014 |
Luteolin inhibits matrix metalloproteinase 9 and 2 in azoxymethane-induced colon carcinogenesis.
Topics: 5'-Nucleotidase; Animals; Antineoplastic Agents; Azoxymethane; Biomarkers, Tumor; Carcinogens; Colonic Neoplasms; gamma-Glutamyltransferase; Luteolin; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice, Inbred BALB C; Tissue Inhibitor of Metalloproteinase-2 | 2014 |
Amelioration of azoxymethane induced-carcinogenesis by reducing oxidative stress in rat colon by natural extracts.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Azoxymethane; Carcinogenesis; Carica; Colon; Colonic Neoplasms; Dietary Supplements; Fruit; Glutathione; Humans; Intestinal Mucosa; Lipid Peroxidation; Lythraceae; Male; Micronuclei, Chromosome-Defective; Oxidative Stress; Phytotherapy; Plant Extracts; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Seaweed | 2014 |
Effects of konjac glucomannan, inulin and cellulose on acute colonic responses to genotoxic azoxymethane.
Topics: Amorphophallus; Animals; Azoxymethane; Cellulose; Colon; Colonic Neoplasms; DNA Damage; Feces; Humans; Inulin; Male; Mannans; Mice; Mice, Inbred C57BL; Microbiota; Mutagens; Plant Extracts | 2014 |
Inhibition of beta-catenin and KRAS expressions by Piper betle in azoxymethane-induced colon cancer of male Fischer 344 rats.
Topics: Animals; Azoxymethane; beta Catenin; Carcinogens; Colonic Neoplasms; Disease Models, Animal; Immunohistochemistry; Male; Phytotherapy; Piper betle; Plant Extracts; Plant Leaves; Precancerous Conditions; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); ras Proteins; Rats; Rats, Inbred F344 | 2013 |
Characterization of azoxymethane-induced colon tumor metastasis to lung in a mouse model relevant to human sporadic colorectal cancer and evaluation of grape seed extract efficacy.
Topics: Animals; Antineoplastic Agents, Phytogenic; Azoxymethane; Colonic Neoplasms; Colorectal Neoplasms; Drug Screening Assays, Antitumor; Grape Seed Extract; Humans; Lung; Lung Neoplasms; Male; Mice, Inbred Strains | 2014 |
Potentiation of colon cancer susceptibility in mice by colonic epithelial PPAR-δ/β overexpression.
Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Disease Susceptibility; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; PPAR-beta; Receptors, Cytoplasmic and Nuclear; Up-Regulation | 2014 |
Mesenchymal stem cells cancel azoxymethane-induced tumor initiation.
Topics: Animals; Azoxymethane; Carcinogens; Cells, Cultured; Coculture Techniques; Colonic Neoplasms; G1 Phase Cell Cycle Checkpoints; Humans; Mesenchymal Stem Cells; Neoplasms, Experimental; Rats; Rats, Inbred Lew; Transforming Growth Factor beta; Wnt Signaling Pathway | 2014 |
Copper metabolism domain-containing 1 represses genes that promote inflammation and protects mice from colitis and colitis-associated cancer.
Topics: Adaptor Proteins, Signal Transducing; Animals; Azoxymethane; Biopsy; Case-Control Studies; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Humans; Inflammation; Inflammatory Bowel Diseases; Mice; Mice, Knockout; NF-kappa B; Polymorphism, Single Nucleotide; RNA, Messenger | 2014 |
Canola oil influence on azoxymethane-induced colon carcinogenesis, hypertriglyceridemia and hyperglycemia in Kunming mice.
Topics: Animals; Azoxymethane; Carcinogenesis; Carcinogens; Colonic Neoplasms; Fatty Acids, Monounsaturated; Female; Hyperglycemia; Hypertriglyceridemia; Male; Mice; Organ Size; Precancerous Conditions; Rapeseed Oil | 2014 |
Cripto haploinsufficiency affects in vivo colon tumor development.
Topics: Animals; Apoptosis; Azoxymethane; Colonic Neoplasms; Endoplasmic Reticulum Chaperone BiP; Epidermal Growth Factor; Female; Gene Expression Regulation, Neoplastic; Haploinsufficiency; Heat-Shock Proteins; Membrane Glycoproteins; Mice; Neoplasm Proteins; Neoplasms, Experimental | 2014 |
Evaluation of chemopreventive effects of Acanthus ilicifolius against azoxymethane-induced aberrant Crypt Foci in the rat colon.
Topics: Aberrant Crypt Foci; Acanthaceae; Animals; Anticarcinogenic Agents; Azoxymethane; Colonic Neoplasms; Female; Male; Plant Extracts; Rats; Rats, Sprague-Dawley | 2014 |
A non-digestible fraction of the common bean (Phaseolus vulgaris L.) induces cell cycle arrest and apoptosis during early carcinogenesis.
Topics: Aberrant Crypt Foci; Animals; Apoptosis; Azoxymethane; Carcinogenesis; Cell Cycle Checkpoints; Cell Line, Tumor; Colon; Colonic Neoplasms; Cooking; Dietary Carbohydrates; Dietary Fiber; Dietary Proteins; Digestion; Flavonoids; Male; Phaseolus; Plant Extracts; Rats; Rats, Sprague-Dawley | 2014 |
Anti-inflammatory effects of betaine on AOM/DSS‑induced colon tumorigenesis in ICR male mice.
Topics: Animals; Anti-Inflammatory Agents; Azoxymethane; Betaine; Cell Line; Colitis; Colonic Neoplasms; Dextran Sulfate; Gene Expression Regulation, Neoplastic; Glutathione; Humans; Macrophages; Male; Mice; Mice, Inbred ICR; Reactive Oxygen Species | 2014 |
Garcinol suppresses inflammation-associated colon carcinogenesis in mice.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; beta Catenin; Colitis; Colonic Neoplasms; Dextran Sulfate; Hepatitis; Inflammation Mediators; Lipid Metabolism; Male; Mice, Inbred ICR; Neoplasms, Experimental; Signal Transduction; Terpenes | 2014 |
[Changes of expression of miR-155 in colitis-associated colonic carcinogenesis].
Topics: Adenocarcinoma; Animals; Azoxymethane; Carcinogens; Cocarcinogenesis; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Gene Expression Profiling; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Precancerous Conditions; Up-Regulation | 2014 |
[Chemo-preventive effect of Angelica sinensis' supercritical extracts on AOM/DSS-induced mouse colorectal carcinoma associated with inflammation].
Topics: Angelica sinensis; Animals; Azoxymethane; Colonic Neoplasms; Colorectal Neoplasms; Cyclooxygenase 2; Dextran Sulfate; Disease Models, Animal; Drugs, Chinese Herbal; Humans; Male; Mice; Mice, Inbred BALB C; Proliferating Cell Nuclear Antigen | 2014 |
The role of corticotropin-releasing hormone receptor 1 in the development of colitis-associated cancer in mouse model.
Topics: Animals; Azoxymethane; Colitis; Colon; Colonic Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; Female; Humans; Male; Mice, Knockout; NF-kappa B; Receptors, Corticotropin-Releasing Hormone; STAT3 Transcription Factor | 2014 |
Kimchi protects against azoxymethane/dextran sulfate sodium-induced colorectal carcinogenesis in mice.
Topics: Animals; Azoxymethane; Brassica; Carcinogenesis; Colon; Colonic Neoplasms; Dextran Sulfate; Humans; Interferon-gamma; Interleukin-6; Male; Mice; Mice, Inbred BALB C; Tumor Necrosis Factor-alpha | 2014 |
Bovine milk-derived α-lactalbumin inhibits colon inflammation and carcinogenesis in azoxymethane and dextran sodium sulfate-treated mice.
Topics: Adenocarcinoma; Adenoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoxymethane; Carcinogenesis; Cattle; Colon; Colonic Neoplasms; Dextran Sulfate; Dietary Supplements; Dinoprostone; Inflammation; Interleukin-1beta; Lactalbumin; Male; Mice; Mice, Inbred C57BL; Milk; Occult Blood; Organ Size; Tumor Necrosis Factor-alpha | 2014 |
Lactoferrin deficiency promotes colitis-associated colorectal dysplasia in mice.
Topics: Animals; Apoptosis; Azoxymethane; Cell Proliferation; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Down-Regulation; Gene Knockout Techniques; Humans; Inflammation; Lactoferrin; Male; Mice; NF-kappa B; Signal Transduction | 2014 |
[Inflammation promotes the development of colitis-associated colorectal cancer].
Topics: Animals; Azoxymethane; Colitis; Colonic Neoplasms; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Immunohistochemistry; Inflammation; Interleukin-6; Mice; Mice, Inbred C57BL; Signal Transduction; STAT3 Transcription Factor; Tumor Necrosis Factor-alpha | 2014 |
Brewers' rice induces apoptosis in azoxymethane-induced colon carcinogenesis in rats via suppression of cell proliferation and the Wnt signaling pathway.
Topics: Animals; Apoptosis; Azoxymethane; beta Catenin; Carcinogenesis; Cell Proliferation; Colonic Neoplasms; Cyclooxygenase 2; Male; Oryza; Rats; Rats, Sprague-Dawley; Wnt Signaling Pathway | 2014 |
Carnosic acid suppresses colon tumor formation in association with antiadipogenic activity.
Topics: 3T3-L1 Cells; Abietanes; Adipocytes; Adipogenesis; Adiponectin; Adiposity; Animals; Apoptosis; Azoxymethane; bcl-X Protein; Cell Proliferation; Colon; Colonic Neoplasms; Cyclin D1; Dextran Sulfate; Extracellular Signal-Regulated MAP Kinases; HT29 Cells; Humans; Insulin; Insulin-Like Growth Factor I; Interleukin-6; Leptin; Male; Mice; Plant Extracts; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Receptors, Leptin; STAT3 Transcription Factor | 2014 |
Aldose reductase inhibition suppresses azoxymethane-induced colonic premalignant lesions in C57BL/KsJ-db/db mice.
Topics: Aldehyde Reductase; Animals; Anticarcinogenic Agents; Azoxymethane; Colon; Colonic Neoplasms; Diabetes Mellitus, Type 2; Disease Models, Animal; Enzyme Inhibitors; HT29 Cells; Humans; Imidazolidines; Inflammation Mediators; Intestinal Mucosa; Male; Mice, Inbred C57BL; Obesity; Oxidative Stress; Precancerous Conditions; Signal Transduction | 2014 |
Nicotine suppresses acute colitis and colonic tumorigenesis associated with chronic colitis in mice.
Topics: Acute Disease; alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Azoxymethane; CD4-Positive T-Lymphocytes; Chronic Disease; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Down-Regulation; Gastrointestinal Agents; Inflammation Mediators; Interleukin-6; Intestinal Mucosa; Male; Mice, Inbred BALB C; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; RNA, Messenger; Severity of Illness Index; STAT3 Transcription Factor; Time Factors; Tumor Necrosis Factor-alpha | 2014 |
Colon carcinogenesis is inhibited by the TRPM8 antagonist cannabigerol, a Cannabis-derived non-psychotropic cannabinoid.
Topics: Animals; Apoptosis; Azoxymethane; Blotting, Western; Cannabinoids; Cannabis; Carcinogens; Cell Proliferation; Cells, Cultured; Colon; Colonic Neoplasms; Flow Cytometry; Humans; Immunoenzyme Techniques; Male; Mice; Mice, Inbred ICR; Mice, Nude; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; TRPM Cation Channels; Xenograft Model Antitumor Assays | 2014 |
Activation of intestinal human pregnane X receptor protects against azoxymethane/dextran sulfate sodium-induced colon cancer.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Dextran Sulfate; HT29 Cells; Humans; Male; Mice; Mice, Knockout; Pregnane X Receptor; Protective Agents; Receptors, Steroid; Rifamycins; Rifaximin | 2014 |
Sex disparity in colonic adenomagenesis involves promotion by male hormones, not protection by female hormones.
Topics: Adenoma; Adenomatous Polyposis Coli; Animals; Animals, Congenic; Azoxymethane; Carcinogens; Colonic Neoplasms; Dihydrotestosterone; Disease Models, Animal; Estradiol; Female; Genes, APC; Gonadal Steroid Hormones; Hormone Replacement Therapy; Humans; Male; Medroxyprogesterone Acetate; Mice; Mice, Inbred C57BL; Mutation; Neoplasms, Hormone-Dependent; Orchiectomy; Organ Specificity; Ovariectomy; Postmenopause; Random Allocation; Rats; Rats, Inbred F344; Rats, Mutant Strains; Receptors, Androgen; RNA, Messenger; Sex Distribution; Species Specificity | 2014 |
Enhanced colonic tumorigenesis in alkaline sphingomyelinase (NPP7) knockout mice.
Topics: Adenocarcinoma; Animals; Azoxymethane; beta Catenin; Carrier Proteins; Colonic Neoplasms; Dextran Sulfate; Intestinal Mucosa; Mice; Mice, Knockout; Sphingolipids; Sphingomyelin Phosphodiesterase | 2015 |
Grape juice concentrate (G8000™) modulates apoptosis but not oxidative stress following rat colon carcinogenesis induced by azoxymethane.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; bcl-2-Associated X Protein; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Deoxyguanosine; Disease Models, Animal; Fruit; Fruit and Vegetable Juices; Male; Oxidative Stress; Phytotherapy; Plants, Medicinal; Proto-Oncogene Proteins c-bcl-2; Rats, Wistar; Time Factors; Vitis | 2015 |
Dynamic changes and functions of macrophages and M1/M2 subpopulations during ulcerative colitis-associated carcinogenesis in an AOM/DSS mouse model.
Topics: Animals; Azoxymethane; Biomarkers; Carcinoma; Cell Transformation, Neoplastic; Colitis, Ulcerative; Colonic Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; Gene Expression; Hyperplasia; Inflammation Mediators; Macrophages; Male; Mice; Neoplasm Metastasis | 2015 |
Dual optical modality endoscopic imaging of cancer development in the mouse colon.
Topics: Adenoma; Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Colonoscopy; Coloring Agents; Female; Methylene Blue; Mice; Observer Variation; Sensitivity and Specificity; Tomography, Optical Coherence | 2015 |
In vivo molecular mapping of the tumor microenvironment in an azoxymethane-treated mouse model of colon carcinogenesis.
Topics: Animals; Azoxymethane; Biomarkers, Tumor; Carcinogenesis; Carcinogens; Colonic Neoplasms; Colonoscopes; Colonoscopy; Disease Progression; Female; Mice; Time Factors; Tomography, Optical Coherence; Tumor Microenvironment | 2015 |
Sulindac reversal of 15-PGDH-mediated resistance to colon tumor chemoprevention with NSAIDs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Aspirin; Azoxymethane; Carcinogens; Celecoxib; Chemoprevention; Colonic Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Hydroxyprostaglandin Dehydrogenases; Inflammation; Intestinal Mucosa; Membrane Proteins; Mice; Mice, Knockout; Pyrazoles; Sulfonamides; Sulindac | 2015 |
Inhibitory effects of astaxanthin on azoxymethane-induced colonic preneoplastic lesions in C57/BL/KsJ-db/db mice.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Antioxidants; Azoxymethane; beta Catenin; Cell Proliferation; Colonic Neoplasms; Inflammation Mediators; Intestinal Mucosa; Male; Mice, Inbred C57BL; NF-kappa B; Obesity; Oxidative Stress; Precancerous Conditions; Xanthophylls | 2014 |
Protective effect ofAgave salmiana fructans in azoxymethane- induced colon cancer in Wistar rats.
Topics: Agave; Animals; Antineoplastic Agents; Azoxymethane; Colonic Neoplasms; Fructans; Rats; Rats, Wistar | 2014 |
Effect of genetic deletion or pharmacological antagonism of tumor necrosis factor alpha on colitis-associated carcinogenesis in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; Etanercept; Female; Mice; Mice, Knockout; NF-kappa B; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha | 2015 |
Role of milk fat globule-epidermal growth factor 8 in colonic inflammation and carcinogenesis.
Topics: Animals; Antigens, Surface; Azoxymethane; Body Weight; Cell Proliferation; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Epithelial Cells; Humans; Integrin alphaVbeta3; Intestinal Mucosa; Mice, Knockout; Milk Proteins; Neoplasm Proteins; Recombinant Proteins; Tumor Cells, Cultured | 2015 |
Diverse roles of STING-dependent signaling on the development of cancer.
Topics: Animals; Azoxymethane; Carcinogenesis; Colonic Neoplasms; Humans; Immunity, Innate; Membrane Proteins; Mice; Mice, Knockout; Signal Transduction; Transcriptional Activation | 2015 |
Protective Effects of Turbinaria ornata and Padina pavonia against Azoxymethane-Induced Colon Carcinogenesis through Modulation of PPAR Gamma, NF-κB and Oxidative Stress.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Azoxymethane; Carcinogenesis; Cell Line, Tumor; Colonic Neoplasms; Glutathione; Glutathione Peroxidase; Humans; Inflammation; Lipid Peroxidation; Male; Malondialdehyde; Mice; NF-kappa B; Nitric Oxide; Oxidative Stress; Phaeophyceae; PPAR gamma; Seaweed; Superoxide Dismutase; Tumor Suppressor Protein p53 | 2015 |
KAG-308, a newly-identified EP4-selective agonist shows efficacy for treating ulcerative colitis and can bring about lower risk of colorectal carcinogenesis by oral administration.
Topics: Administration, Oral; Animals; Azoxymethane; Benzoates; Biological Availability; Cells, Cultured; Colitis, Ulcerative; Colonic Neoplasms; Cyclopropanes; Dextran Sulfate; Epoprostenol; Female; Healthy Volunteers; Humans; Intestinal Mucosa; Mice; Receptors, Prostaglandin E, EP4 Subtype; Sulfasalazine; Tumor Necrosis Factor-alpha | 2015 |
Nrf2-dependent suppression of azoxymethane/dextran sulfate sodium-induced colon carcinogenesis by the cinnamon-derived dietary factor cinnamaldehyde.
Topics: Acrolein; Animals; Anticarcinogenic Agents; Azoxymethane; Carcinogenesis; Chemoprevention; Cinnamomum zeylanicum; Colonic Neoplasms; Cytoprotection; Dextran Sulfate; Diet; HCT116 Cells; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-E2-Related Factor 2 | 2015 |
15-Lipoxygenase-1 suppression of colitis-associated colon cancer through inhibition of the IL-6/STAT3 signaling pathway.
Topics: Animals; Arachidonate 15-Lipoxygenase; Azoxymethane; Blotting, Western; Caco-2 Cells; Cell Line, Tumor; Cell Proliferation; Colitis; Colonic Neoplasms; Dextran Sulfate; Gene Expression; HCT116 Cells; Humans; Immunohistochemistry; Interleukin-6; Mice, Transgenic; Phosphorylation; PPAR delta; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; STAT3 Transcription Factor | 2015 |
NF-κB1, NF-κB2 and c-Rel differentially regulate susceptibility to colitis-associated adenoma development in C57BL/6 mice.
Topics: Adenoma; Animals; Azoxymethane; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; Disease Susceptibility; Epithelial Cells; Female; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B p50 Subunit; NF-kappa B p52 Subunit; Proto-Oncogene Proteins c-rel; Signal Transduction | 2015 |
T-cells enhance stem cell mutagenesis in the mouse colon.
Topics: Animals; Azoxymethane; Colon; Colonic Neoplasms; Dextran Sulfate; DNA Damage; Drug Synergism; Guanine; Inflammation; Male; Mice, Inbred C57BL; Mice, Knockout; Mutagenesis; Receptors, Antigen, T-Cell, alpha-beta; Stem Cells; T-Lymphocytes | 2015 |
Antagonizing pathways leading to differential dynamics in colon carcinogenesis in Shugoshin1 (Sgo1)-haploinsufficient chromosome instability model.
Topics: Animals; Azoxymethane; Cell Cycle Proteins; Cell Line, Tumor; Chromosomal Instability; Colonic Neoplasms; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Haploinsufficiency; Humans; Mice; Neoplasms, Experimental; Oncogenes; Signal Transduction | 2016 |
SPINK1 Status in Colorectal Cancer, Impact on Proliferation, and Role in Colitis-Associated Cancer.
Topics: Aged; Animals; Azoxymethane; Carrier Proteins; Cell Line, Tumor; Cell Proliferation; Colitis; Colonic Neoplasms; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Female; Glycoproteins; Humans; Inflammation; Japan; Male; Mice, Inbred C57BL; Middle Aged; Prostatic Secretory Proteins; Trypsin Inhibitor, Kazal Pancreatic | 2015 |
Unpolished Thai rice prevents ACF formation and dysplastic progression in AOM-induced rats and induces apoptosis through redox alteration in CaCo-2 cells.
Topics: Aberrant Crypt Foci; Animals; Apoptosis; Azoxymethane; Caco-2 Cells; Carcinogens; Cell Proliferation; Colonic Neoplasms; Diet; Disease Progression; Flow Cytometry; Humans; Male; Oryza; Oxidation-Reduction; Oxidative Stress; Precancerous Conditions; Rats; Rats, Sprague-Dawley | 2015 |
Epsin is required for Dishevelled stability and Wnt signalling activation in colon cancer development.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Adenocarcinoma; Animals; Azoxymethane; Binding Sites; Colitis; Colon; Colonic Neoplasms; Dishevelled Proteins; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Mice; Mice, Knockout; Phosphoproteins; Primary Cell Culture; Protein Binding; Protein Interaction Domains and Motifs; Protein Stability; RNA, Small Interfering; Sodium Dodecyl Sulfate; Wnt Signaling Pathway; Xenograft Model Antitumor Assays | 2015 |
NPC1L1 knockout protects against colitis-associated tumorigenesis in mice.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azoxymethane; beta Catenin; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Homozygote; Intestinal Mucosa; Lipids; Membrane Transport Proteins; Mice; Mice, Knockout; Transforming Growth Factor beta; Tumor Suppressor Protein p53 | 2015 |
Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis.
Topics: Adenocarcinoma; Animals; Azoxymethane; Bacteroides fragilis; Blotting, Western; Carcinogenesis; Carcinogens; Cell Line, Tumor; Cell Proliferation; Chemokine CCL20; Colitis; Colonic Neoplasms; Dextran Sulfate; Dinoprostone; Disease Models, Animal; Enterobacteriaceae; Exosomes; Immunohistochemistry; In Situ Hybridization, Fluorescence; Inflammation; Intestinal Mucosa; Lysophospholipids; Mice; Myeloid Differentiation Factor 88; Nanoparticles; Neoplasm Transplantation; Reverse Transcriptase Polymerase Chain Reaction; Sphingosine; Th17 Cells | 2015 |
IL-32α suppresses colorectal cancer development via TNFR1-mediated death signaling.
Topics: Adenocarcinoma; Animals; Apoptosis; Azoxymethane; Cell Line, Tumor; Colonic Neoplasms; Colorectal Neoplasms; Enzyme Activation; Humans; Inflammation; Interleukins; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Transgenic; Neoplasm Proteins; Reactive Oxygen Species; Receptors, Tumor Necrosis Factor, Type I; Recombinant Fusion Proteins; Signal Transduction | 2015 |
Development of an oral nanotherapeutics using redox nanoparticles for treatment of colitis-associated colon cancer.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Azoxymethane; Camptothecin; Cell Line, Tumor; Colitis; Colonic Neoplasms; Dextrans; Drug Delivery Systems; Drug Screening Assays, Antitumor; Endoscopy; Free Radical Scavengers; Inflammation; Irinotecan; Male; Mice; Mice, Inbred ICR; Nanomedicine; Nanoparticles; Neoplasms, Experimental; Nitrogen Oxides; Oxidation-Reduction; Reactive Oxygen Species; Sulfates | 2015 |
HIC1 Tumor Suppressor Loss Potentiates TLR2/NF-κB Signaling and Promotes Tissue Damage-Associated Tumorigenesis.
Topics: Animals; Azoxymethane; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Epithelial Cells; Gene Knockdown Techniques; Humans; Intestines; Kruppel-Like Transcription Factors; Mice; Mice, Transgenic; NF-kappa B; Signal Transduction; Toll-Like Receptor 2; Tumor Suppressor Proteins; Up-Regulation | 2015 |
Impaired skin barrier function in mice with colon carcinoma induced by azoxymethane and dextran sodium sulfate.
Topics: Animals; Azoxymethane; Cell Membrane Permeability; Collagen Type I; Colon; Colonic Neoplasms; Dextran Sulfate; Male; Mice, Hairless; Nitrogen Dioxide; Nitrogen Oxides; Skin; Water | 2015 |
MicroRNA214 Is Associated With Progression of Ulcerative Colitis, and Inhibition Reduces Development of Colitis and Colitis-Associated Cancer in Mice.
Topics: Adaptor Proteins, Signal Transducing; Animals; Azoxymethane; Biomarkers, Tumor; Case-Control Studies; Cell Line; Colitis, Ulcerative; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Disease Progression; Gene Expression Regulation, Neoplastic; Humans; Inflammation Mediators; Interleukin-6; LIM Domain Proteins; Mice; MicroRNAs; NF-kappa B; Phosphorylation; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; RNA Interference; RNAi Therapeutics; Signal Transduction; STAT3 Transcription Factor; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 2015 |
Calpain-2 Inhibitor Therapy Reduces Murine Colitis and Colitis-associated Cancer.
Topics: Animals; Azoxymethane; Cell Proliferation; Colitis; Colonic Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; HT29 Cells; Humans; I-kappa B Proteins; Inflammation; Injections, Intraperitoneal; Macrophage Activation; Mice; NF-kappa B; Oligopeptides; Translocation, Genetic | 2015 |
Curcumin ameliorates the tumor-enhancing effects of a high-protein diet in an azoxymethane-induced mouse model of colon carcinogenesis.
Topics: Ammonia; Animals; Azoxymethane; Carcinogenesis; Cell Proliferation; Colon; Colonic Neoplasms; Curcumin; Cyclooxygenase 2; Diet; Dietary Proteins; Fatty Acids; Feces; Female; Mice; Mice, Inbred BALB C; Nitric Oxide; Nitric Oxide Synthase Type II; Tumor Necrosis Factor-alpha | 2015 |
Colon carcinogenesis in wild type and immune compromised mice after treatment with azoxymethane, and azoxymethane with dextran sodium sulfate.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Dextran Sulfate; Immunocompromised Host; Incidence; Mice; Mice, Inbred BALB C; Mice, Nude; Receptors, Antigen, T-Cell | 2016 |
FGF-1/-3/FGFR4 signaling in cancer-associated fibroblasts promotes tumor progression in colon cancer through Erk and MMP-7.
Topics: Animals; Azoxymethane; Cell Line, Tumor; Colitis, Ulcerative; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Disease Progression; Extracellular Signal-Regulated MAP Kinases; Fibroblast Growth Factor 1; Fibroblast Growth Factor 3; Fibroblasts; HCT116 Cells; HT29 Cells; Human Umbilical Vein Endothelial Cells; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 7; Mice; Phosphorylation; Pyrimidines; Receptor Protein-Tyrosine Kinases; Receptor, Fibroblast Growth Factor, Type 4; Receptors, Fibroblast Growth Factor; RNA Interference; RNA, Small Interfering | 2015 |
Mast Cells Infiltrating Inflamed or Transformed Gut Alternatively Sustain Mucosal Healing or Tumor Growth.
Topics: Animals; Animals, Congenic; Azoxymethane; Carcinoma; Cell Count; Cell Transformation, Neoplastic; Cells, Cultured; Colitis; Colonic Neoplasms; Dextran Sulfate; Epithelial Cells; Humans; Inflammatory Bowel Diseases; Interleukin-1 Receptor-Like 1 Protein; Interleukin-33; Intestinal Mucosa; Mast Cells; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; Proto-Oncogene Proteins c-kit; Receptors, Interleukin; Regeneration; Serine Endopeptidases; Species Specificity; Specific Pathogen-Free Organisms | 2015 |
The chemopreventive potential of Curcuma purpurascens rhizome in reducing azoxymethane-induced aberrant crypt foci in rats.
Topics: Aberrant Crypt Foci; Animals; Antioxidants; Apoptosis; Azoxymethane; Chemoprevention; Colonic Neoplasms; Curcuma; Dose-Response Relationship, Drug; Fluorouracil; Male; Oxidative Stress; Plant Extracts; Rats; Rats, Sprague-Dawley; Rhizome | 2015 |
Chemoprevention of Azoxymethane-induced Colonic Carcinogenesis in Balb/c mice Using a Modified Pectin Alginate Probiotic.
Topics: Alginates; Animals; Azoxymethane; Carcinogenesis; Chemoprevention; Colon; Colonic Neoplasms; Disease Models, Animal; Galectins; Glucuronic Acid; Hexuronic Acids; Immunohistochemistry; Male; Mice, Inbred BALB C; Pectins; Probiotics; Vascular Endothelial Growth Factor A | 2015 |
Nexrutine inhibits azoxymethane-induced colonic aberrant crypt formation in rat colon and induced apoptotic cell death in colon adenocarcinoma cells.
Topics: Aberrant Crypt Foci; Animals; Apoptosis; Azoxymethane; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colonic Neoplasms; Cyclin D1; Cyclooxygenase 2; Gene Expression Regulation, Neoplastic; Humans; Male; Nitric Oxide Synthase Type II; Plant Extracts; Rats; Xenograft Model Antitumor Assays | 2016 |
Brewers' rice modulates oxidative stress in azoxymethane-mediated colon carcinogenesis in rats.
Topics: Animals; Antioxidants; Azoxymethane; beta Catenin; Carcinogenesis; Colon; Colonic Neoplasms; Dietary Supplements; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Heme Oxygenase (Decyclizing); Male; Malondialdehyde; NF-E2-Related Factor 2; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Oryza; Oxidative Stress; Plant Preparations; Rats, Sprague-Dawley; Superoxide Dismutase; Transcription, Genetic; Transcriptional Activation; Wnt Signaling Pathway | 2015 |
In vivo regulation of colonic cell proliferation, differentiation, apoptosis, and P27Kip1 by dietary fish oil and butyrate in rats.
Topics: Animals; Apoptosis; Azoxymethane; Butyrates; Cell Differentiation; Cell Proliferation; Colon; Colonic Neoplasms; Corn Oil; Cyclin-Dependent Kinase Inhibitor p27; Dietary Fats, Unsaturated; DNA Damage; Fermentation; Fish Oils; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Ki-67 Antigen; Male; Pectins; Rats; Rats, Sprague-Dawley | 2015 |
Human Colon Tumors Express a Dominant-Negative Form of SIGIRR That Promotes Inflammation and Colitis-Associated Colon Cancer in Mice.
Topics: Animals; Azoxymethane; Cell Membrane; Colitis; Colon; Colonic Neoplasms; Cytosol; Dextran Sulfate; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, Dominant; Genetic Predisposition to Disease; Glycosylation; HeLa Cells; Humans; Inflammation Mediators; Intestinal Mucosa; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Oligonucleotide Array Sequence Analysis; Phenotype; Protein Processing, Post-Translational; Receptors, Interleukin-1; RNA, Messenger; Signal Transduction; Tissue Culture Techniques; Transfection | 2015 |
Anthocyanin-containing purple-fleshed potatoes suppress colon tumorigenesis via elimination of colon cancer stem cells.
Topics: Animals; Anthocyanins; Antineoplastic Agents; Apoptosis; Azoxymethane; bcl-2-Associated X Protein; beta Catenin; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Colonic Neoplasms; Cytochromes c; Food; Humans; In Situ Nick-End Labeling; Lentivirus; Male; Mice; Mitochondria; Neoplastic Stem Cells; RNA, Small Interfering; Solanum tuberosum; Sulindac; Tumor Suppressor Protein p53; Wnt Proteins | 2015 |
A hypermorphic epithelial β-catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations.
Topics: Adenomatous Polyps; Animals; Azoxymethane; beta Catenin; Cell Transformation, Neoplastic; Colitis; Colon; Colonic Neoplasms; Colonic Polyps; Cytokines; Gene Expression Regulation, Neoplastic; Genes, APC; Genetic Predisposition to Disease; Heterozygote; Homozygote; Humans; Matrix Metalloproteinase 7; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Neoplasm Staging; Neovascularization, Pathologic; Paneth Cells; Phenotype; Tenascin; Tumor Microenvironment; Wnt Signaling Pathway | 2015 |
Expanding Functionality of Commercial Optical Coherence Tomography Systems by Integrating a Custom Endoscope.
Topics: Adenoma; Algorithms; Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Endoscopes; Endoscopy; Mice, Inbred Strains; Models, Theoretical; Reproducibility of Results; Sensitivity and Specificity; Tomography, Optical Coherence | 2015 |
Effects of Two Traditional Chinese Cooking Oils, Canola and Pork, on pH and Cholic Acid Content of Faeces and Colon Tumorigenesis in Kunming Mice.
Topics: Animals; Azoxymethane; Carcinogenesis; Cholic Acid; Colon; Colonic Neoplasms; Dietary Fats, Unsaturated; Fatty Acids, Monounsaturated; Feces; Female; Hydrogen-Ion Concentration; Male; Mice; Oils; Organ Size; Rapeseed Oil; Swine | 2015 |
Chemopreventive activity of grape juice concentrate (G8000TM) on rat colon carcinogenesis induced by azoxymethane.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Cyclooxygenase 2; Disease Models, Animal; Fruit and Vegetable Juices; Gene Expression Regulation, Neoplastic; Ki-67 Antigen; Male; Plant Extracts; Rats; Rats, Wistar; Vitis | 2015 |
Dead Nano-Sized Lactobacillus plantarum Inhibits Azoxymethane/Dextran Sulfate Sodium-Induced Colon Cancer in Balb/c Mice.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Carcinogenesis; Cell Cycle Checkpoints; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Immunoglobulin A; Inflammation; Lactobacillus plantarum; Mice, Inbred BALB C; Particle Size | 2015 |
Combination Treatment of Murine Colon Cancer with Doxorubicin and Redox Nanoparticles.
Topics: Animals; Antibiotics, Antineoplastic; Azoxymethane; Carcinogens; Colonic Neoplasms; Combined Modality Therapy; Doxorubicin; Drug Carriers; Hydrogen-Ion Concentration; Male; Mice; Mice, Inbred ICR; Nanoparticles; Nitrogen Oxides; Oxidation-Reduction; Reactive Oxygen Species | 2016 |
Genetic-deletion of Cyclooxygenase-2 Downstream Prostacyclin Synthase Suppresses Inflammatory Reactions but Facilitates Carcinogenesis, unlike Deletion of Microsomal Prostaglandin E Synthase-1.
Topics: Acetic Acid; Animals; Azoxymethane; Carcinogenesis; Colonic Neoplasms; Colonic Polyps; Cyclooxygenase 2; Cytochrome P-450 Enzyme System; Dinoprostone; Epoprostenol; Intramolecular Oxidoreductases; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Nociception; Pain; Peritonitis; Prostaglandin-E Synthases; Thioglycolates | 2015 |
Sonic hedgehog inhibitors prevent colitis-associated cancer via orchestrated mechanisms of IL-6/gp130 inhibition, 15-PGDH induction, Bcl-2 abrogation, and tumorsphere inhibition.
Topics: Animals; Apoptosis; Azoxymethane; Blotting, Western; Cell Movement; Cell Proliferation; Cerulenin; Colitis; Colonic Neoplasms; Cytokine Receptor gp130; Fatty Acid Synthesis Inhibitors; Flow Cytometry; Fluorescent Antibody Technique; Hedgehog Proteins; Humans; Hydroxyprostaglandin Dehydrogenases; Immunoenzyme Techniques; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Proto-Oncogene Proteins c-bcl-2; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spheroids, Cellular; Tumor Cells, Cultured; Xenograft Model Antitumor Assays; Zinc Finger Protein GLI1 | 2016 |
The Impact of Dietary Energy Intake Early in Life on the Colonic Microbiota of Adult Mice.
Topics: Animals; Azoxymethane; Bacteroidetes; Caloric Restriction; Carcinogens; Colonic Neoplasms; Diet, High-Fat; Dietary Fats; Disease Progression; Energy Intake; Female; Firmicutes; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Microbiota | 2016 |
MicroRNA-155 deletion promotes tumorigenesis in the azoxymethane-dextran sulfate sodium model of colon cancer.
Topics: Animals; Apoptosis; Azoxymethane; Biomarkers; Carcinogens; Cell Proliferation; Colonic Neoplasms; Dextran Sulfate; Gene Deletion; Humans; Intestinal Mucosa; Mice; Mice, Inbred C57BL; MicroRNAs; Signal Transduction; Smad Proteins; Transfection; Transforming Growth Factor beta | 2016 |
Imaging colon cancer development in mice: IL-6 deficiency prevents adenoma in azoxymethane-treated Smad3 knockouts.
Topics: Adenoma; Animals; Azoxymethane; Colonic Neoplasms; Interleukin-6; Male; Mice; Smad3 Protein; Tomography, Optical Coherence | 2016 |
Hydrolysed inulin alleviates the azoxymethane-induced preneoplastic aberrant crypt foci by altering selected intestinal microbiota in Sprague-Dawley rats.
Topics: Aberrant Crypt Foci; Animals; Anticarcinogenic Agents; Azoxymethane; Bacteria; Bacterial Load; Biomass; Colon; Colonic Neoplasms; Disease Models, Animal; Gastrointestinal Microbiome; Hydrolysis; Inulin; Male; Rats, Sprague-Dawley; Time Factors | 2016 |
KLF4 Suppresses Tumor Formation in Genetic and Pharmacological Mouse Models of Colonic Tumorigenesis.
Topics: Adenomatous Polyposis Coli Protein; Animals; Azoxymethane; Cells, Cultured; Colonic Neoplasms; Epigenesis, Genetic; Gene Deletion; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Intestinal Mucosa; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Mice; Mutation; Neoplasms, Experimental; TOR Serine-Threonine Kinases | 2016 |
Chronic ethanol feeding promotes azoxymethane and dextran sulfate sodium-induced colonic tumorigenesis potentially by enhancing mucosal inflammation.
Topics: Animals; Azoxymethane; Biomarkers, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Chemokines; Colonic Neoplasms; Cytokines; Dextran Sulfate; Ethanol; Female; Gene Expression; Inflammation; Intestinal Mucosa; Mice; Protein Transport | 2016 |
The Innate Immune Receptor NLRX1 Functions as a Tumor Suppressor by Reducing Colon Tumorigenesis and Key Tumor-Promoting Signals.
Topics: Adenomatous Polyposis Coli Protein; Animals; Antibodies, Monoclonal, Humanized; Azoxymethane; Biomarkers, Tumor; Carcinogenesis; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Humans; Interleukin-6; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Fluorescence; Mitochondrial Proteins; Mitogen-Activated Protein Kinases; NF-kappa B; Real-Time Polymerase Chain Reaction; Signal Transduction; STAT3 Transcription Factor | 2016 |
[Changes of macrophages in colitis-associated colonic carcinogenesis].
Topics: Animals; Azoxymethane; Carcinogenesis; Carcinogens; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Granulocyte Colony-Stimulating Factor; Macrophages; Mice; Mice, Inbred C57BL; Phenotype; Real-Time Polymerase Chain Reaction | 2016 |
High-fat diets rich in saturated fat protect against azoxymethane/dextran sulfate sodium-induced colon cancer.
Topics: Animals; Apoptosis; Azoxymethane; Cell Proliferation; Colonic Neoplasms; Diet, High-Fat; Dietary Fats; Fatty Acids; Female; Male; Mice; Mice, Inbred C57BL; Sodium Dodecyl Sulfate | 2016 |
Vancomycin-sensitive bacteria trigger development of colitis-associated colon cancer by attracting neutrophils.
Topics: Animals; Azoxymethane; Bacteria; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; DNA Damage; Gene Expression Regulation; Humans; Mice; Neutrophils; Vancomycin | 2016 |
The Mbd4 DNA glycosylase protects mice from inflammation-driven colon cancer and tissue injury.
Topics: Animals; Apoptosis; Azoxymethane; Colon; Colonic Neoplasms; Dextran Sulfate; DNA Glycosylases; Endodeoxyribonucleases; Humans; Inflammation; Intestinal Mucosa; Kaplan-Meier Estimate; Mice, Knockout; Tumor Burden | 2016 |
Acute blockade of IL-25 in a colitis associated colon cancer model leads to increased tumor burden.
Topics: Animals; Antibodies, Neutralizing; Azoxymethane; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Eosinophils; Gene Deletion; Gene Expression Regulation; Interleukin-17; Mice, Inbred BALB C; Tumor Burden | 2016 |
Effect of Dietary Fibers on Cecal Microbiota and Intestinal Tumorigenesis in Azoxymethane Treated A/J Min/+ Mice.
Topics: Analysis of Variance; Animals; Azoxymethane; Bacteroidetes; Body Weight; Carcinogenesis; Cecum; Cellulose; Colon; Colonic Neoplasms; Diet; Dietary Fiber; Firmicutes; High-Throughput Nucleotide Sequencing; Inulin; Male; Mice; Mice, Inbred C57BL; Microbiota; RNA, Ribosomal, 16S | 2016 |
The epigenetic effects of aspirin: the modification of histone H3 lysine 27 acetylation in the prevention of colon carcinogenesis in azoxymethane- and dextran sulfate sodium-treated CF-1 mice.
Topics: Animals; Anticarcinogenic Agents; Aspirin; Azoxymethane; Colitis; Colonic Neoplasms; Cyclooxygenase 2; Dextran Sulfate; Epigenesis, Genetic; Histone Deacetylases; Histones; Lysine; Male; Mice, Inbred Strains; Neoplasms, Experimental; Nitric Oxide Synthase Type II | 2016 |
Effects of Walnut Consumption on Colon Carcinogenesis and Microbial Community Structure.
Topics: Animals; Azoxymethane; Bacteria; Carcinogenesis; Carcinogens; Colonic Neoplasms; Colonoscopy; Diet; DNA, Bacterial; Feces; Female; Gastrointestinal Microbiome; Immunohistochemistry; Male; Mice; Mice, Inbred A; Nuts; Sex Factors; Statistics, Nonparametric | 2016 |
American Ginseng Attenuates Colitis-Associated Colon Carcinogenesis in Mice: Impact on Gut Microbiota and Metabolomics.
Topics: Animals; Azoxymethane; Carcinogenesis; Colitis; Colonic Neoplasms; Dextran Sulfate; Gastrointestinal Microbiome; Male; Metabolomics; Mice; Panax | 2016 |
Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth.
Topics: Adenocarcinoma; Animals; Azoxymethane; Bone Morphogenetic Proteins; Carcinogenesis; Cell Proliferation; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Down-Regulation; Gene Expression Regulation, Neoplastic; Hedgehog Proteins; Integrases; Mice, Inbred C57BL; Recombination, Genetic; Signal Transduction; Stromal Cells; Transcription, Genetic; Tumor Burden | 2016 |
In vivo endoscopic Doppler optical coherence tomography imaging of the colon.
Topics: Adenocarcinoma; Animals; Azoxymethane; Colonic Neoplasms; Disease Models, Animal; Endosonography; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Sensitivity and Specificity; Tomography, Optical Coherence | 2017 |
Weight loss following diet-induced obesity does not alter colon tumorigenesis in the AOM mouse model.
Topics: Animals; Azoxymethane; Body Weight; Carcinogenesis; Cell Proliferation; Colon; Colonic Neoplasms; Diet, High-Fat; Disease Models, Animal; Liver; Liver Neoplasms; Macrophages; Mice; Obesity; T-Lymphocytes; Weight Loss | 2016 |
Daikenchuto (TU-100) Suppresses Tumor Development in the Azoxymethane and APC
Topics: Animals; Azoxymethane; Colonic Neoplasms; Disease Models, Animal; Male; Medicine, Traditional; Mice; Panax; Plant Extracts; Zanthoxylum; Zingiberaceae | 2017 |
Oral administration of a recombinant cholera toxin B subunit promotes mucosal healing in the colon.
Topics: Administration, Oral; Animals; Azoxymethane; Caco-2 Cells; Cholera; Cholera Toxin; Cholera Vaccines; Colitis, Ulcerative; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Female; Humans; Mice; Mice, Inbred C57BL; Mucous Membrane; Signal Transduction; Transforming Growth Factor beta; Wound Healing | 2017 |
The role of Pygo2 for Wnt/ß-catenin signaling activity during intestinal tumor initiation and progression.
Topics: Adenoma; Animals; Azoxymethane; beta Catenin; Cell Proliferation; Cell Transformation, Neoplastic; Colonic Neoplasms; Disease Models, Animal; Disease Progression; Gene Expression Regulation, Neoplastic; Genes, APC; Genetic Predisposition to Disease; Intracellular Signaling Peptides and Proteins; Mice, Inbred C57BL; Mice, Knockout; Mutation; Phenotype; Proto-Oncogene Proteins c-myc; Time Factors; Tumor Burden; Wnt Signaling Pathway | 2016 |
Repression of MicroRNA Function Mediates Inflammation-associated Colon Tumorigenesis.
Topics: Animals; Azoxymethane; Caco-2 Cells; Carcinogenesis; Carcinoma; Cell Line, Tumor; Colitis; Colon; Colonic Neoplasms; Cytidine Deaminase; Cytokines; DEAD-box RNA Helicases; Dextran Sulfate; Fibroblasts; Flow Cytometry; HCT116 Cells; HT29 Cells; Humans; Immunoblotting; Immunohistochemistry; Inflammation; Interleukin-1alpha; Interleukin-1beta; Mice; MicroRNAs; Ribonuclease III; Tumor Necrosis Factor-alpha | 2017 |
Rapidly cycling Lgr5
Topics: Aberrant Crypt Foci; Animals; Apoptosis; Azoxymethane; beta Catenin; Carcinogenesis; Carcinogens; Cell Cycle; Cell Differentiation; Cell Nucleus; Chemoprevention; Colon; Colonic Neoplasms; Curcumin; Diet; DNA Breaks, Double-Stranded; DNA Modification Methylases; DNA Repair Enzymes; Fatty Acids, Omega-3; Fish Oils; Green Fluorescent Proteins; Mice; Receptors, G-Protein-Coupled; Regeneration; Risk Factors; Signal Transduction; Stem Cells; Subcellular Fractions; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2016 |
Activins and their related proteins in colon carcinogenesis: insights from early and advanced azoxymethane rat models of colon cancer.
Topics: Activins; Adenocarcinoma; Animals; Azoxymethane; Biomarkers, Tumor; Carcinogenesis; Colonic Neoplasms; Disease Progression; Follistatin; Gene Expression; Male; Precancerous Conditions; Rats, Wistar | 2016 |
Plum polyphenols inhibit colorectal aberrant crypt foci formation in rats: potential role of the miR-143/protein kinase B/mammalian target of rapamycin axis.
Topics: Aberrant Crypt Foci; Animals; Anticarcinogenic Agents; Azoxymethane; Cell Proliferation; Chlorogenic Acid; Colon; Colonic Neoplasms; Diet; Inflammation Mediators; Intestinal Mucosa; Male; MicroRNAs; Phosphorylation; Plant Extracts; Polyphenols; Proto-Oncogene Proteins c-akt; Prunus domestica; Quinic Acid; Rats, Sprague-Dawley; TOR Serine-Threonine Kinases | 2016 |
Fusobacterium nucleatum Increases Proliferation of Colorectal Cancer Cells and Tumor Development in Mice by Activating Toll-Like Receptor 4 Signaling to Nuclear Factor-κB, and Up-regulating Expression of MicroRNA-21.
Topics: Adenomatous Polyposis Coli Protein; Aged; Animals; Azoxymethane; Carcinogenesis; Cell Movement; Cell Proliferation; Colitis; Colonic Neoplasms; Dextran Sulfate; DNA, Bacterial; Down-Regulation; Female; Fusobacterium Infections; Fusobacterium nucleatum; Gene Expression Regulation, Neoplastic; HCT116 Cells; HT29 Cells; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; MicroRNAs; Myeloid Differentiation Factor 88; NF-kappa B; p120 GTPase Activating Protein; Prognosis; RNA, Small Interfering; Signal Transduction; Toll-Like Receptor 4; Up-Regulation | 2017 |
T lymphocyte SHP2-deficiency triggers anti-tumor immunity to inhibit colitis-associated cancer in mice.
Topics: Animals; Azoxymethane; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cells, Cultured; Colitis; Colonic Neoplasms; Cytotoxicity, Immunologic; Dextran Sulfate; Disease Models, Animal; Fas Ligand Protein; Granzymes; Inflammation Mediators; Interferon-gamma; Lymphocytes, Tumor-Infiltrating; Mice, Knockout; Perforin; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Signal Transduction; STAT1 Transcription Factor; Time Factors; Tumor Microenvironment | 2017 |
Cilostazol and enzymatically modified isoquercitrin attenuate experimental colitis and colon cancer in mice by inhibiting cell proliferation and inflammation.
Topics: Animals; Azoxymethane; Carcinogens; Cell Proliferation; Cilostazol; Colitis; Colonic Neoplasms; Enzyme-Linked Immunosorbent Assay; Female; Immunohistochemistry; Inflammation; Mice; Mice, Inbred BALB C; Organ Size; Quercetin; Tetrazoles; Vasodilator Agents | 2017 |
Ultraviolet A eye irradiation ameliorates colon carcinoma induced by azoxymethane and dextran sodium sulfate through β-endorphin and methionine-enkephalin.
Topics: Aminoquinolines; Animals; Azoxymethane; Benzamides; beta-Endorphin; Colon; Colonic Neoplasms; Dextran Sulfate; Enkephalin, Methionine; Eye; Female; Interleukin-6; Ki-67 Antigen; Mice, Inbred ICR; Naltrexone; Receptors, Opioid; Receptors, Opioid, mu; Tumor Necrosis Factor-alpha; Ultraviolet Rays | 2017 |
Daily Intake of High-Fat Diet with Lysophosphatidic Acid-Rich Soybean Phospholipids Augments Colon Tumorigenesis in Kyoto Apc Delta Rats.
Topics: Animals; Azoxymethane; Carcinogenesis; Carcinogens; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Complex Mixtures; Dextran Sulfate; Diet, High-Fat; Disease Models, Animal; Dose-Response Relationship, Drug; Food-Drug Interactions; Glycine max; Intestinal Mucosa; Lysophospholipids; Rats; Statistics as Topic | 2017 |
Peptostreptococcus anaerobius Induces Intracellular Cholesterol Biosynthesis in Colon Cells to Induce Proliferation and Causes Dysplasia in Mice.
Topics: Acetophenones; Adenoma; Aged; AMP-Activated Protein Kinases; Animals; Azoxymethane; Biopsy; Biosynthetic Pathways; Caco-2 Cells; Case-Control Studies; Cell Proliferation; Cholesterol; Colon; Colonic Neoplasms; DNA, Bacterial; Enzyme Inhibitors; Feces; Gene Expression; Gram-Positive Bacterial Infections; HT29 Cells; Humans; Male; Mice; Mice, Inbred C57BL; Middle Aged; Peptostreptococcus; Reactive Oxygen Species; Signal Transduction; Sterol Regulatory Element Binding Protein 2; Toll-Like Receptor 2; Toll-Like Receptor 4; Up-Regulation | 2017 |
Dietary polyacetylenes, falcarinol and falcarindiol, isolated from carrots prevents the formation of neoplastic lesions in the colon of azoxymethane-induced rats.
Topics: Animal Feed; Animals; Anticarcinogenic Agents; Azoxymethane; Colon; Colonic Neoplasms; Daucus carota; Diynes; Fatty Alcohols; Humans; Male; Plant Extracts; Polyynes; Rats; Rats, Inbred F344 | 2017 |
Synergistic chemopreventive effects of nobiletin and atorvastatin on colon carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Atorvastatin; Azoxymethane; Carcinogenesis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chemoprevention; Colon; Colonic Neoplasms; Drug Synergism; Drug Therapy, Combination; Flavones; HT29 Cells; Humans; Male; Mice; Rats; Rats, Inbred F344 | 2017 |
WD-repeat protein WDR13 is a novel transcriptional regulator of c-Jun and modulates intestinal homeostasis in mice.
Topics: Animals; Azoxymethane; Cell Cycle Proteins; Cell Line; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Gene Expression Regulation, Neoplastic; HEK293 Cells; Homeostasis; HT29 Cells; Humans; MCF-7 Cells; Mice; Nuclear Proteins; Proto-Oncogene Proteins c-jun; Signal Transduction | 2017 |
Boswellia serrata resin extract alleviates azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced colon tumorigenesis.
Topics: Animals; Azoxymethane; Boswellia; Cell Proliferation; Colonic Neoplasms; Cyclin D1; Dextran Sulfate; Glycogen Synthase Kinase 3 beta; Male; MAP Kinase Signaling System; Mice; Mice, Inbred ICR; Plant Extracts; Proto-Oncogene Proteins c-akt; Resins, Plant | 2017 |
The high affinity peroxisome proliferator-activated receptor-gamma agonist RS5444 inhibits both initiation and progression of colon tumors in azoxymethane-treated mice.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colonic Neoplasms; Disease Progression; Immunohistochemistry; Mice; Mice, Inbred C57BL; PPAR gamma; Thiazolidinediones | 2008 |
Tumor necrosis factor alpha and colitis-associated colon cancer.
Topics: Animals; Azoxymethane; Chronic Disease; Colitis, Ulcerative; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Etanercept; Humans; Immunoglobulin G; Mice; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2008 |
Effects of resistant starch on colonic preneoplastic aberrant crypt foci in rats.
Topics: Animals; Azoxymethane; Body Weight; Carcinogens; Cecum; Colon; Colonic Neoplasms; Diet; Dietary Fiber; Eating; Feces; Gastrointestinal Transit; Hydrogen-Ion Concentration; Intestinal Mucosa; Male; Organ Size; Precancerous Conditions; Rats; Rats, Wistar; Solanum tuberosum; Starch | 2008 |
Dehydroalanine and lysinoalanine in thermolyzed casein do not promote colon cancer in the rat.
Topics: Alanine; Animals; Azoxymethane; Carcinogenicity Tests; Caseins; Cheese; Colonic Neoplasms; Diet; Feces; Female; Hot Temperature; Intestinal Mucosa; Lysinoalanine; Rats; Rats, Inbred F344 | 2008 |
Antiproliferative effect of sulindac in colonic neoplasia prevention: role of COOH-terminal Src kinase.
Topics: Animals; Antineoplastic Agents; Azoxymethane; Cell Cycle; Cell Proliferation; Colon; Colonic Neoplasms; CSK Tyrosine-Protein Kinase; Cyclin-Dependent Kinase Inhibitor p21; Down-Regulation; Drug Screening Assays, Antitumor; Enzyme Induction; HT29 Cells; Humans; Male; Models, Biological; Protein-Tyrosine Kinases; Rats; Rats, Inbred F344; src-Family Kinases; Sulindac | 2008 |
The role of the transcription factor AP-1 in colitis-associated and beta-catenin-dependent intestinal tumorigenesis in mice.
Topics: Animals; Azoxymethane; beta Catenin; Colitis; Colonic Neoplasms; Genes, APC; Intestinal Mucosa; Mice; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-jun; Signal Transduction; Transcription Factor AP-1 | 2008 |
Dark Aberrant Crypt Foci with activated Wnt pathway are related to tumorigenesis in the colon of AOM-treated rat.
Topics: Animals; Azoxymethane; beta Catenin; Carcinogens; Colon; Colonic Neoplasms; Intestinal Mucosa; Male; Matrix Metalloproteinase 7; Precancerous Conditions; Rats; Rats, Wistar; Signal Transduction; Wnt Proteins | 2008 |
Protective role of luteolin on the status of lipid peroxidation and antioxidant defense against azoxymethane-induced experimental colon carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Lipid Peroxidation; Luteolin; Male; Mice; Mice, Inbred BALB C | 2008 |
Aqueous and ethanolic extract fractions from the Brazilian propolis suppress azoxymethane-induced aberrant crypt foci in rats.
Topics: Animals; Anti-Infective Agents; Azoxymethane; Carcinogens; Colonic Neoplasms; Ethanol; Immunoenzyme Techniques; Male; Plant Extracts; Precancerous Conditions; Propolis; Rats; Rats, Wistar | 2008 |
Composition and chemopreventive effect of polysaccharides from common beans (Phaseolus vulgaris L.) on azoxymethane-induced colon cancer.
Topics: Animals; Azoxymethane; Butyrates; Cecum; Colonic Neoplasms; Gene Expression; Hot Temperature; Phaseolus; Plant Extracts; Polysaccharides; Rats; Rats, Sprague-Dawley | 2008 |
Effects of combination of calcium and aspirin on azoxymethane-induced aberrant crypt foci formation in the colons of mice and rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Azoxymethane; Calcium, Dietary; Carcinogens; Colon; Colonic Neoplasms; Dietary Fats; Disease Models, Animal; Drug Therapy, Combination; Female; Male; Mice; Rats | 2008 |
A novel prodrug of 4'-geranyloxy-ferulic acid suppresses colitis-related colon carcinogenesis in mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adenocarcinoma; Animals; Anticarcinogenic Agents; Azoxymethane; Carcinogens; Chemoprevention; Colitis; Colonic Neoplasms; Coumaric Acids; Deoxyguanosine; Dextran Sulfate; Dipeptides; Disease Models, Animal; Heme Oxygenase (Decyclizing); Intestinal Mucosa; Male; Mice; Mice, Inbred ICR; Oxidative Stress; Prodrugs | 2008 |
Modulation of intestinal environment by prebiotic germinated barley foodstuff prevents chemo-induced colonic carcinogenesis in rats.
Topics: Animals; Azoxymethane; beta Catenin; Colonic Neoplasms; Germination; Glucuronidase; Heat-Shock Proteins; Hordeum; HSP27 Heat-Shock Proteins; Male; Neoplasm Proteins; Phytotherapy; Probiotics; Rats; Rats, Inbred F344 | 2008 |
Role for sphingosine kinase 1 in colon carcinogenesis.
Topics: Animals; Azoxymethane; Cell Transformation, Neoplastic; Colonic Neoplasms; Cyclooxygenase 2; Dextran Sulfate; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Inflammation; Lysophospholipids; Mice; Mice, Knockout; Phosphotransferases (Alcohol Group Acceptor); Sphingosine | 2009 |
Use of a novel genetic mouse model to investigate the role of folate in colitis-associated colon cancer.
Topics: Animals; Azoxymethane; Biomarkers; Brain Chemistry; Carcinogens; Carrier Proteins; Colitis; Colonic Neoplasms; Dextran Sulfate; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Deficiency; Food, Formulated; Heterozygote; Homocysteine; Intestinal Mucosa; Membrane Transport Proteins; Mice; Mice, Knockout; Models, Animal; Nutritional Status; Precancerous Conditions; Receptors, Cell Surface; Reduced Folate Carrier Protein | 2009 |
Effect of berberine on the antioxidant status, ultrastructural modifications and protein bound carbohydrates in azoxymethane-induced colon cancer in rats.
Topics: Animals; Antioxidants; Azoxymethane; Berberine; Blood Proteins; Carbohydrate Metabolism; Carcinogens; Colonic Neoplasms; Lipid Peroxidation; Male; Microscopy, Electron, Transmission; Rats; Rats, Wistar | 2009 |
Citrus compounds inhibit inflammation- and obesity-related colon carcinogenesis in mice.
Topics: Animals; Azoxymethane; Citrus; Colitis; Colonic Neoplasms; Coumarins; Cyclooxygenase 2; Interleukin-1beta; Mice; NF-kappa B; Nitric Oxide Synthase Type II; Obesity; Precancerous Conditions; Tumor Necrosis Factor-alpha | 2008 |
Chemopreventive effects of the standardized extract (DA-9601) of Artemisia asiatica on azoxymethane-initiated and dextran sulfate sodium-promoted mouse colon carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Artemisia; Azoxymethane; beta Catenin; Colon; Colonic Neoplasms; Cyclooxygenase 2; Dextran Sulfate; DNA; Male; Mice; Mice, Inbred ICR; NF-kappa B; Nitric Oxide Synthase Type II; Plant Extracts | 2008 |
Melatonin suppresses AOM/DSS-induced large bowel oncogenesis in rats.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Apoptosis; Azoxymethane; Biomarkers, Tumor; Colon; Colonic Neoplasms; Dextran Sulfate; Dose-Response Relationship, Drug; Drinking; Immunohistochemistry; Injections, Intraperitoneal; Interleukin-1beta; Intestinal Mucosa; Male; Melatonin; Mitotic Index; NF-kappa B; Rats; Rats, Inbred F344; STAT3 Transcription Factor; Tumor Necrosis Factor-alpha | 2009 |
Aldose reductase deficiency in mice prevents azoxymethane-induced colonic preneoplastic aberrant crypt foci formation.
Topics: Aldehyde Reductase; Animals; Azoxymethane; Colonic Neoplasms; DNA Primers; Lipid Peroxidation; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidative Stress; Precancerous Conditions; Protein Kinase C; Protein Kinase C beta; Reverse Transcriptase Polymerase Chain Reaction | 2009 |
Alkylation-induced colon tumorigenesis in mice deficient in the Mgmt and Msh6 proteins.
Topics: Alkylating Agents; Alkylation; Animals; Apoptosis; Azoxymethane; Carcinogens; Carcinoma; Colonic Neoplasms; Dextran Sulfate; DNA Modification Methylases; DNA Repair Enzymes; DNA-Binding Proteins; Genes, APC; Genetic Predisposition to Disease; Mice; Mice, Inbred C57BL; Mice, Knockout; Tumor Suppressor Proteins | 2009 |
An n-3 PUFA-rich microalgal oil diet protects to a similar extent as a fish oil-rich diet against AOM-induced colonic aberrant crypt foci in F344 rats.
Topics: Animal Feed; Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Corn Oil; Dietary Fats; Disease Models, Animal; Eukaryota; Fatty Acids, Omega-3; Fish Oils; Intestinal Mucosa; Male; Oxidative Stress; Plant Oils; Precancerous Conditions; Rats; Rats, Inbred F344 | 2009 |
The innate immune receptor Nod1 protects the intestine from inflammation-induced tumorigenesis.
Topics: Animals; Azoxymethane; Chemokines; Colitis; Colonic Neoplasms; Cytokines; Dextran Sulfate; Female; Genes, APC; Immunity, Innate; Intestines; Male; Mice; Mice, Inbred C57BL; Nod1 Signaling Adaptor Protein; Receptors, Immunologic; RNA, Messenger; Specific Pathogen-Free Organisms | 2008 |
Elevated circulating adiponectin and elevated insulin sensitivity in adiponectin transgenic mice are not associated with reduced susceptibility to colon carcinogenesis.
Topics: Adiponectin; Animals; Azoxymethane; Carcinogens; Cells, Cultured; Colon; Colonic Neoplasms; Disease Susceptibility; Female; Glucose Tolerance Test; Humans; Insulin; Insulin Resistance; Insulin-Like Growth Factor I; Male; Mice; Mice, Transgenic; Precancerous Conditions; Weight Gain | 2009 |
(-)-Epigallocatechin gallate suppresses azoxymethane-induced colonic premalignant lesions in male C57BL/KsJ-db/db mice.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Carcinoma; Catechin; Cholesterol; Colonic Neoplasms; Diabetes Mellitus, Experimental; Drug Evaluation, Preclinical; Insulin; Intestinal Mucosa; Leptin; Male; Mice; Mice, Inbred C57BL; Precancerous Conditions; Receptor, IGF Type 1; Triglycerides | 2008 |
Inhibition of azoxymethane-induced colonic aberrant crypt foci formation by silibinin in male Fisher 344 rats.
Topics: Animals; Antineoplastic Agents; Azoxymethane; Carcinogens; Carcinoma; Colonic Neoplasms; Cyclin D1; Cyclooxygenase 2; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Intestinal Mucosa; Male; Nitric Oxide Synthase Type II; Precancerous Conditions; Proliferating Cell Nuclear Antigen; Rats; Rats, Inbred F344; Silybin; Silymarin | 2008 |
Estrogen receptor-beta as a potential target for colon cancer prevention: chemoprevention of azoxymethane-induced colon carcinogenesis by raloxifene in F344 rats.
Topics: Animals; Antineoplastic Agents; Azoxymethane; Blotting, Western; Carcinogens; Cell Line, Tumor; Chemoprevention; Colonic Neoplasms; Estrogen Receptor beta; Humans; Immunohistochemistry; Intestinal Mucosa; Male; Maximum Tolerated Dose; Raloxifene Hydrochloride; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction | 2009 |
Inflammation-associated serum and colon markers as indicators of dietary attenuation of colon carcinogenesis in ob/ob mice.
Topics: Animals; Azoxymethane; Biomarkers, Tumor; Carcinogens; Colonic Neoplasms; Cytokines; Diet; Fabaceae; Gene Expression; Inflammation; Interleukin-6; Male; Mice; Mice, Obese; Obesity; Phytotherapy; Plant Extracts; Precancerous Conditions; Reverse Transcriptase Polymerase Chain Reaction | 2009 |
Soy isoflavones modulate azoxymethane-induced rat colon carcinogenesis exposed pre- and postnatally and inhibit growth of DLD-1 human colon adenocarcinoma cells by increasing the expression of estrogen receptor-beta.
Topics: Adenocarcinoma; Animals; Animals, Newborn; Azoxymethane; Carcinogens; Cell Line, Tumor; Colonic Neoplasms; Diet; Estrogen Receptor beta; Female; Gene Expression Regulation, Neoplastic; Glycine max; Humans; Isoflavones; Male; Pregnancy; Prenatal Exposure Delayed Effects; Random Allocation; Rats; Rats, Sprague-Dawley | 2009 |
Protein kinase C betaII and PKCiota/lambda: collaborating partners in colon cancer promotion and progression.
Topics: Adenoma; Animals; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colonic Neoplasms; Disease Progression; Genes, APC; Humans; Isoenzymes; Mice; Mice, Knockout; Mice, Transgenic; Protein Kinase C; Protein Kinase C beta | 2009 |
A gamma-tocopherol-rich mixture of tocopherols inhibits colon inflammation and carcinogenesis in azoxymethane and dextran sulfate sodium-treated mice.
Topics: Adenocarcinoma; Adenoma; Animals; Antioxidants; Apoptosis; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Cocarcinogenesis; Colon; Colonic Neoplasms; Dextran Sulfate; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; gamma-Tocopherol; Inflammation; Leukotriene B4; Male; Mice; Tyrosine | 2009 |
Fatty acid synthase is over-expressed in large aberrant crypt foci in rats treated with azoxymethane.
Topics: Animals; Azoxymethane; Cell Nucleus; Colonic Neoplasms; Fatty Acid Synthases; Immunohistochemistry; Male; Precancerous Conditions; Rats; Rats, Inbred F344 | 2009 |
Egg yolk proteins suppress azoxymethane-induced aberrant crypt foci formation and cell proliferation in the colon of rats.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Bromodeoxyuridine; Carcinogens; Caseins; Cecum; Cell Proliferation; Colon; Colonic Neoplasms; DNA; Egg Proteins; Fatty Acids, Volatile; Intestinal Mucosa; Male; Precancerous Conditions; Rats; Rats, Inbred F344 | 2009 |
Effects of dietary flaxseed on intestinal tumorigenesis in Apc(Min) mouse.
Topics: Adenomatous Polyposis Coli; alpha-Linolenic Acid; Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Colon; Colonic Neoplasms; Corn Oil; Cyclooxygenase 1; Cyclooxygenase 2; Diet; Fatty Acids; Fatty Acids, Omega-3; Flax; Intestinal Neoplasms; Intestine, Small; Lignans; Linseed Oil; Mice; Phytotherapy; Zea mays | 2009 |
The absence of LPA2 attenuates tumor formation in an experimental model of colitis-associated cancer.
Topics: Animals; Azoxymethane; beta Catenin; Cell Proliferation; Chemokine CCL2; Colitis; Colonic Neoplasms; Cyclooxygenase 2; Cytokines; Disease Progression; Genes, APC; Kruppel-Like Transcription Factors; Lipopolysaccharides; Macrophage Migration-Inhibitory Factors; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Lysophosphatidic Acid | 2009 |
3,3'-diindolylmethane attenuates colonic inflammation and tumorigenesis in mice.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Body Weight; Carcinogens; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Dextran Sulfate; Dinoprostone; Disease Models, Animal; Indoles; Mice; Mice, Inbred BALB C; NF-kappa B; Nitric Oxide; Peroxidase; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Weight Loss | 2009 |
Supplementation with branched-chain amino acids inhibits azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db mice.
Topics: Amino Acids, Branched-Chain; Animals; Azoxymethane; beta Catenin; Body Weight; Carcinogens; Colonic Neoplasms; Diabetes Mellitus, Experimental; Dietary Supplements; Insulin; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Male; Mice; Mice, Inbred C57BL; Mice, Nude; Obesity; Organ Size; Precancerous Conditions; Proliferating Cell Nuclear Antigen; Receptor, IGF Type 1; Receptor, IGF Type 2; Tumor Cells, Cultured | 2009 |
Reduced susceptibility to azoxymethane-induced aberrant crypt foci formation and colon cancer in growth hormone deficient rats.
Topics: Animals; Apoptosis; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Disease Susceptibility; Growth Hormone; Male; Rats; Rats, Sprague-Dawley | 2009 |
Inhibition of colon carcinogenesis by post-initiation induction of NQO1 in Sprague-Dawley rats.
Topics: Adenoma; Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Enzyme Induction; Glucuronosyltransferase; Glutathione Transferase; Intestinal Mucosa; Male; NAD(P)H Dehydrogenase (Quinone); Neoplasms, Experimental; Precancerous Conditions; Pyrazines; Rats; Rats, Sprague-Dawley; Thiones; Thiophenes; Time Factors | 2009 |
Mucin-depleted foci show strong activation of inflammatory markers in 1,2-dimethylhydrazine-induced carcinogenesis and are promoted by the inflammatory agent sodium dextran sulfate.
Topics: 1,2-Dimethylhydrazine; Animals; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Down-Regulation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Immunohistochemistry; Inflammation; Male; Mucin-2; Nitric Oxide Synthase Type II; Precancerous Conditions; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; Up-Regulation | 2009 |
Targeted genetic disruption of peroxisome proliferator-activated receptor-delta and colonic tumorigenesis.
Topics: Animals; Azoxymethane; Cell Line, Tumor; Colonic Neoplasms; Disease Models, Animal; Exons; Gene Deletion; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Transgenic; Models, Genetic; PPAR delta; Reverse Transcriptase Polymerase Chain Reaction; Vascular Endothelial Growth Factor A | 2009 |
Anticarcinogenic efficacy of phytic acid extracted from rice bran on azoxymethane-induced colon carcinogenesis in rats.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Carcinogens; Colonic Neoplasms; Dietary Fiber; Male; Oryza; Phytic Acid; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley | 2010 |
Carcinogenic effects of exogenous and endogenous glucagon-like peptide-2 in azoxymethane-treated mice.
Topics: Animals; Azoxymethane; Cell Proliferation; Colonic Neoplasms; Glucagon-Like Peptide 2; Humans; Intestines; Mice; Mice, Inbred C57BL | 2009 |
Adiponectin is not effective against AOM-induced colon cancer but more evidence is required for its role in obesity-associated colon cancer: comment on the study by Ealey and Archer (2009).
Topics: Adiponectin; Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Mice; Obesity | 2009 |
Chemopreventive effect of raw and cooked lentils (Lens culinaris L) and soybeans (Glycine max) against azoxymethane-induced aberrant crypt foci.
Topics: Animals; Antineoplastic Agents, Phytogenic; Azoxymethane; Colon; Colonic Neoplasms; Cooking; Glutathione Transferase; Glycine max; Lens Plant; Liver; Male; Phytotherapy; Plant Preparations; Random Allocation; Rats; Rats, Inbred F344; Seeds | 2009 |
Long-term ingestion of reduced glutathione suppressed an accelerating effect of beef tallow diet on colon carcinogenesis in rats.
Topics: Animals; Antioxidants; Arachidonic Acid; Azoxymethane; beta Catenin; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Cyclooxygenase 2; Disease Models, Animal; Fats; Glutathione; Glutathione Reductase; Intestinal Mucosa; Male; Oxidative Stress; Precancerous Conditions; Random Allocation; Rats; Rats, Sprague-Dawley | 2009 |
Epithelial vanin-1 controls inflammation-driven carcinogenesis in the colitis-associated colon cancer model.
Topics: Amidohydrolases; Animals; Azoxymethane; Blotting, Western; Carcinogens; Cell Adhesion Molecules; Colitis; Colonic Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; Epithelial Cells; Female; Fluorescent Antibody Technique; GPI-Linked Proteins; Inflammation; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; NF-kappa B; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2010 |
Synbiotic intervention of Bifidobacterium lactis and resistant starch protects against colorectal cancer development in rats.
Topics: Animals; Apoptosis; Azoxymethane; Bifidobacterium; Blotting, Western; Carcinogens; Colonic Neoplasms; Combined Modality Therapy; Diet; Male; Probiotics; Rats; Rats, Sprague-Dawley; Starch; Vitamin B Complex | 2010 |
Inhibition of colon carcinogenesis by 2-methoxy-5-amino-N-hydroxybenzamide, a novel derivative of mesalamine.
Topics: Aminosalicylic Acids; Animals; Anticarcinogenic Agents; Azoxymethane; Benzamides; Carcinogens; Cell Death; Cell Division; Colitis; Colonic Neoplasms; Cyclin D1; Dextran Sulfate; eIF-2 Kinase; Endoplasmic Reticulum; Flow Cytometry; G1 Phase; Gene Silencing; HCT116 Cells; Humans; Mesalamine; Mice; Resting Phase, Cell Cycle; Xenograft Model Antitumor Assays | 2010 |
Lack of efficacy of blueberry in nutritional prevention of azoxymethane-initiated cancers of rat small intestine and colon.
Topics: Adenocarcinoma; Adenomatous Polyps; Animals; Azoxymethane; Blueberry Plants; C-Peptide; Colonic Neoplasms; Disease Models, Animal; Disease Progression; Duodenal Neoplasms; Female; Incidence; Male; Nutrition Therapy; Rats; Rats, Sprague-Dawley | 2009 |
Pla2g2a attenuates colon tumorigenesis in azoxymethane-treated C57BL/6 mice; expression studies reveal Pla2g2a target genes and pathways.
Topics: Animals; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colonic Neoplasms; Disease Models, Animal; Female; Gene Expression Regulation, Neoplastic; Group II Phospholipases A2; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic | 2009 |
Genetic reduction of circulating insulin-like growth factor-1 inhibits azoxymethane-induced colon tumorigenesis in mice.
Topics: Animals; Apoptosis; Azoxymethane; Carcinogens; Cell Proliferation; Colonic Neoplasms; Immunoenzyme Techniques; Insulin-Like Growth Factor I; Integrases; Liver; Mice; Mice, Knockout; Mice, Transgenic | 2009 |
Blockade of a chemokine, CCL2, reduces chronic colitis-associated carcinogenesis in mice.
Topics: Animals; Azoxymethane; Chemokine CCL2; Colitis, Ulcerative; Colonic Neoplasms; Cyclooxygenase 2; Dextran Sulfate; Female; Germanium; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Transgenic; Organometallic Compounds; Propionates; Receptors, CCR2; RNA, Messenger | 2009 |
Aberrant DNA methylation occurs in colon neoplasms arising in the azoxymethane colon cancer model.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis Regulatory Proteins; Azoxymethane; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion Molecule-1; Cell Adhesion Molecules; Colonic Neoplasms; Connexins; Cyclin-Dependent Kinase Inhibitor p16; Death-Associated Protein Kinases; Disease Models, Animal; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; DNA-Binding Proteins; Gap Junction delta-2 Protein; Humans; Immunoglobulins; Inhibitor of Differentiation Proteins; Insulin-Like Growth Factor Binding Protein 3; Intestinal Mucosa; Membrane Proteins; Mice; MutL Protein Homolog 1; Nuclear Proteins; Receptors, CXCR4; Repressor Proteins; Transcription Factors; Tumor Suppressor Proteins | 2010 |
n-3 Polyunsaturated fatty acids modulate carcinogen-directed non-coding microRNA signatures in rat colon.
Topics: Adenocarcinoma; Animals; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Epigenesis, Genetic; Fatty Acids, Unsaturated; Fish Oils; Gene Expression Profiling; Male; MicroRNAs; Pectins; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction | 2009 |
Identification of actively translated mRNA transcripts in a rat model of early-stage colon carcinogenesis.
Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Fatty Acids, Omega-3; Gene Expression Profiling; Genes; Immunoenzyme Techniques; Male; Oligonucleotide Array Sequence Analysis; Polyribosomes; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2009 |
Chemopreventive efficacy of naproxen and nitric oxide-naproxen in rodent models of colon, urinary bladder, and mammary cancers.
Topics: Alkylating Agents; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoxymethane; Butylhydroxybutylnitrosamine; Carcinogens; Colonic Neoplasms; Diet; Female; Male; Mammary Neoplasms, Experimental; Methylnitrosourea; Naproxen; Nitric Oxide Donors; Precancerous Conditions; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Urinary Bladder Neoplasms | 2009 |
Epidermal growth factor receptor is required for colonic tumor promotion by dietary fat in the azoxymethane/dextran sulfate sodium model: roles of transforming growth factor-{alpha} and PTGS2.
Topics: Animals; Azoxymethane; Blood Glucose; Colonic Neoplasms; Cyclooxygenase 2; Dextran Sulfate; ErbB Receptors; Gene Expression Regulation, Neoplastic; Insulin; Insulin Resistance; Ligands; Mice; Mice, Inbred C57BL; Point Mutation; Transforming Growth Factor alpha | 2009 |
Dietary flavonoids suppress azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db mice.
Topics: Animals; Antioxidants; Azoxymethane; Carcinogens; Colonic Neoplasms; Dietary Supplements; Flavones; Flavonoids; Insulin; Leptin; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Precancerous Conditions; Quercetin | 2010 |
Characterization of a major colon cancer susceptibility locus (Ccs3) on mouse chromosome 3.
Topics: Animals; Azoxymethane; Carcinogens; Chromosome Mapping; Chromosomes, Mammalian; Colonic Neoplasms; Gene Expression; Gene Expression Profiling; Genetic Loci; Genetic Predisposition to Disease; Humans; Mice; Mice, Congenic; Oligonucleotide Array Sequence Analysis; Sequence Homology, Nucleic Acid | 2010 |
Apoptosis signal-regulating kinase 1 regulates colitis and colitis-associated tumorigenesis by the innate immune responses.
Topics: Animals; Apoptosis; Azoxymethane; Bone Marrow Transplantation; Cell Proliferation; Cells, Cultured; Citrobacter rodentium; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Disease Susceptibility; Female; Gene Expression Regulation; Humans; Immunity, Innate; Macrophages; Male; MAP Kinase Kinase Kinase 5; Mice; Mice, Inbred C57BL; Mice, Knockout; p38 Mitogen-Activated Protein Kinases; Phagocytosis; RNA Interference; Severity of Illness Index; Time Factors | 2010 |
Increased visceral fat mass and insulin signaling in colitis-related colon carcinogenesis model mice.
Topics: Animals; Azoxymethane; Carcinogens; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Insulin; Insulin-Like Growth Factor I; Intra-Abdominal Fat; Leptin; Male; Mice; Mice, Inbred ICR; Signal Transduction | 2010 |
Dietary tricin suppresses inflammation-related colon carcinogenesis in male Crj: CD-1 mice.
Topics: Adenocarcinoma; Adenoma; Animals; Azoxymethane; Blotting, Western; Carcinogens; Colonic Neoplasms; Diet; Flavonoids; Inflammation; Male; Mice; Mice, Inbred ICR; Phytotherapy; Plant Extracts; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2009 |
Luteolin inhibits cell proliferation during Azoxymethane-induced experimental colon carcinogenesis via Wnt/ β-catenin pathway.
Topics: Animals; Azoxymethane; beta Catenin; Blotting, Western; Cell Proliferation; Colonic Neoplasms; Cyclin D1; Drug Screening Assays, Antitumor; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Luteolin; Male; Mice; Polyamines; Proliferating Cell Nuclear Antigen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Silver Staining; Wnt Proteins | 2011 |
Long-term administration of aspirin inhibits tumour formation and triggers anti-neoplastic molecular changes in a pre-clinical model of colon carcinogenesis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Aspirin; Azoxymethane; Carcinogens; Carcinoma; Cell Transformation, Neoplastic; Colonic Neoplasms; Drug Evaluation, Preclinical; Gene Expression Regulation, Neoplastic; Immunity, Innate; Inflammation Mediators; Male; Neoplasms, Experimental; Rats; Rats, Wistar; Time Factors | 2010 |
CD95 is cytoprotective for intestinal epithelial cells in colitis.
Topics: Animals; Azoxymethane; Bone Marrow Transplantation; Carcinogens; Cell Transformation, Neoplastic; Colitis, Ulcerative; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Fas Ligand Protein; fas Receptor; Intestinal Mucosa; Mice; Mice, Knockout | 2010 |
Tumor formation in a mouse model of colitis-associated colon cancer does not require COX-1 or COX-2 expression.
Topics: Animals; Azoxymethane; Colitis; Colonic Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Dextran Sulfate; Genes, APC; Membrane Proteins; Mice; Mice, Knockout; NF-kappa B; Toll-Like Receptor 4 | 2010 |
Dietary intake of pterostilbene, a constituent of blueberries, inhibits the beta-catenin/p65 downstream signaling pathway and colon carcinogenesis in rats.
Topics: Animals; Azoxymethane; beta Catenin; Colonic Neoplasms; Cyclin D1; Cyclooxygenase 2; Cytokines; HT29 Cells; Humans; Male; Nitric Oxide Synthase Type II; Phosphorylation; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins c-myc; Rats; Rats, Inbred F344; Signal Transduction; Stilbenes; Transcription Factor RelA | 2010 |
Expression profiles of proliferative and antiapoptotic genes in sporadic and colitis-related mouse colon cancer models.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Azoxymethane; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Cell Cycle Proteins; Cell Proliferation; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Cyclooxygenase 2; Dextran Sulfate; Disease Models, Animal; Disease Progression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Inhibitor of Apoptosis Proteins; Male; Mice; Mice, Inbred ICR; Microdissection; Microtubule-Associated Proteins; Nitric Oxide Synthase Type II; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-myb; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; Survivin; Telomerase; Transcription Factor 4 | 2010 |
Comment on: Dietary flavonoids suppress azoxymethane-induced colonic preneoplastic lesions in male C57BL/Ksj-db/db mice.
Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Dietary Supplements; Flavonoids; Male; Mice; Mice, Inbred C57BL | 2010 |
Modulating effect of Withania somnifera on TCA cycle enzymes and electron transport chain in azoxymethane-induced colon cancer in mice.
Topics: Animals; Antineoplastic Agents, Phytogenic; Azoxymethane; Citric Acid Cycle; Colonic Neoplasms; Electron Transport; Male; Mice; Mice, Inbred Strains; Plant Extracts; Withania | 2010 |
Conjugated linoleic acid suppresses colon carcinogenesis in azoxymethane-pretreated rats with long-term feeding of diet containing beef tallow.
Topics: Animals; Apoptosis; Arachidonic Acid; Azoxymethane; Cattle; Cell Proliferation; Colonic Neoplasms; Dietary Fats; Fats; Linoleic Acids, Conjugated; Male; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Signal Transduction; Time Factors; Wnt Proteins | 2010 |
Elevated expression of tumor necrosis factor-alpha signaling molecules in colonic tumors of Zucker obese (fa/fa) rats.
Topics: Animals; Azoxymethane; Blood Cell Count; Colonic Neoplasms; Female; NF-kappa B; NF-kappaB-Inducing Kinase; Obesity; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Rats, Zucker; Receptors, Tumor Necrosis Factor, Type II; Signal Transduction; Tumor Necrosis Factor-alpha | 2010 |
Deer velvet supplementation decreases the grade and metastasis of azoxymethane-induced colon cancer in the male rat.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Azoxymethane; Colonic Neoplasms; Disease Models, Animal; Male; Neoplasm Metastasis; Rats; Rats, Wistar; Skin; Tissue Extracts | 2010 |
Colitis-associated cancer is dependent on the interplay between the hemostatic and inflammatory systems and supported by integrin alpha(M)beta(2) engagement of fibrinogen.
Topics: Adenoma; Animals; Azoxymethane; Carcinogens; Cell Growth Processes; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Cytokines; Dextran Sulfate; Disease Progression; Fibronectins; Hemostasis; Macrophage-1 Antigen; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic | 2010 |
Bifidobacterium lactis inhibits NF-kappaB in intestinal epithelial cells and prevents acute colitis and colitis-associated colon cancer in mice.
Topics: Acute Disease; Animals; Azoxymethane; Bifidobacteriales Infections; Bifidobacterium; Blotting, Western; Carcinogens; Chronic Disease; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Electrophoretic Mobility Shift Assay; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Immunoenzyme Techniques; Inflammation; Intestinal Mucosa; Lipopolysaccharides; Luciferases; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2010 |
Germinated brown rice (GBR) reduces the incidence of aberrant crypt foci with the involvement of beta-catenin and COX-2 in azoxymethane-induced colon cancer in rats.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; beta Catenin; Carcinogens; Colon; Colonic Neoplasms; Cyclooxygenase 2; Diet; Germination; Immunohistochemistry; Male; Oryza; Rats; Rats, Sprague-Dawley; Seeds | 2010 |
Resveratrol from transgenic alfalfa for prevention of aberrant crypt foci in mice.
Topics: Animals; Azoxymethane; Body Weight; Chromatography, High Pressure Liquid; Colonic Neoplasms; Eating; Female; Glucosides; Lactase-Phlorizin Hydrolase; Medicago sativa; Mice; Plants, Genetically Modified; Precancerous Conditions; Resveratrol; Stilbenes | 2010 |
Chlorogenic acid differentially alters hepatic and small intestinal thiol redox status without protecting against azoxymethane-induced colon carcinogenesis in mice.
Topics: Animals; Azoxymethane; Body Weight; Chlorogenic Acid; Colonic Neoplasms; Eating; Glutathione; Intestine, Small; Liver; Mice; Oxidation-Reduction; Precancerous Conditions; Sulfhydryl Compounds | 2010 |
Pitavastatin inhibits azoxymethane-induced colonic preneoplastic lesions in C57BL/KsJ-db/db obese mice.
Topics: Animals; Azoxymethane; Carcinogens; Cell Division; Colonic Neoplasms; Cytokines; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Precancerous Conditions; Quinolines | 2010 |
Identification of gene expression profiles correlated to tumor progression in a preclinical model of colon carcinogenesis.
Topics: Animals; Azoxymethane; Biomarkers, Tumor; Carcinogens; Cell Transformation, Neoplastic; Colonic Neoplasms; Disease Models, Animal; Disease Progression; Gene Expression Profiling; Male; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2010 |
Intake of grape-derived polyphenols reduces C26 tumor growth by inhibiting angiogenesis and inducing apoptosis.
Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Azoxymethane; Cell Line, Tumor; Colonic Neoplasms; Female; Flavonoids; Immunohistochemistry; In Situ Nick-End Labeling; Male; Mice; Mice, Inbred BALB C; Phenols; Polyphenols; Random Allocation; Rats; Rats, Wistar; Vitis | 2010 |
Epimorphin deletion protects mice from inflammation-induced colon carcinogenesis and alters stem cell niche myofibroblast secretion.
Topics: Animals; Azoxymethane; Cell Proliferation; Cell Transformation, Neoplastic; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Epithelial Cells; Inflammation; Interleukin-6; Intestinal Mucosa; Mice; Mice, Congenic; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth; Sequence Deletion | 2010 |
Apigenin and naringenin suppress colon carcinogenesis through the aberrant crypt stage in azoxymethane-treated rats.
Topics: Animals; Antineoplastic Agents; Apigenin; Apoptosis; Azoxymethane; Blotting, Western; Cell Proliferation; Citrus; Colon; Colonic Neoplasms; Cyclooxygenase 2; Diet; Flavanones; Histocytochemistry; Male; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley | 2010 |
Freeze-dried ham promotes azoxymethane-induced mucin-depleted foci and aberrant crypt foci in rat colon.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Female; Freeze Drying; Hemin; Lipid Peroxidation; Meat Products; Mucins; Precancerous Conditions; Rats; Rats, Inbred F344; Swine | 2010 |
2,3',4,4',5'-Pentamethoxy-trans-stilbene, a resveratrol derivative, inhibits colitis-associated colorectal carcinogenesis in mice.
Topics: Adenocarcinoma; Animals; Apoptosis; Azoxymethane; Cell Line, Tumor; Cell Proliferation; Colitis; Colonic Neoplasms; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred BALB C; Stilbenes | 2010 |
Dietary linoleic acid and glucose enhances azoxymethane-induced colon cancer and metastases via the expression of high-mobility group box 1.
Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Diet; Drug Synergism; Glucose; HMGB1 Protein; Linoleic Acid; Male; Random Allocation; Rats; Rats, Inbred F344 | 2010 |
MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18.
Topics: Adenocarcinoma; Animals; Apoptosis; Azoxymethane; beta Catenin; Cell Proliferation; Colon; Colonic Neoplasms; Colonic Polyps; Cyclooxygenase 2; Dextran Sulfate; DNA Repair Enzymes; Epithelial Cells; Gene Expression; Gene Expression Profiling; Genetic Predisposition to Disease; Inflammatory Bowel Diseases; Interleukin-18; Interleukin-18 Receptor alpha Subunit; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Myeloid Differentiation Factor 88; Phosphorylation; Receptors, Interleukin-1 Type I; Signal Transduction; Specific Pathogen-Free Organisms; STAT3 Transcription Factor | 2010 |
Regular exercise reduces colon tumorigenesis associated with suppression of iNOS.
Topics: Animals; Azoxymethane; Body Weight; Cell Transformation, Neoplastic; Citrate (si)-Synthase; Colonic Neoplasms; Cyclooxygenase 2; Male; Mice; Mice, Inbred BALB C; Nitric Oxide Synthase Type II; Physical Conditioning, Animal; Tumor Necrosis Factor-alpha | 2010 |
The role of prostaglandin E2 (PGE 2) in toll-like receptor 4 (TLR4)-mediated colitis-associated neoplasia.
Topics: Amphiregulin; Animals; Azoxymethane; Cell Proliferation; Colitis; Colonic Neoplasms; Cyclooxygenase 2; Dextran Sulfate; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; EGF Family of Proteins; ErbB Receptors; Female; Glycoproteins; Intercellular Signaling Peptides and Proteins; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Prostaglandins; Signal Transduction; Toll-Like Receptor 4 | 2010 |
Pterostilbene inhibits colorectal aberrant crypt foci (ACF) and colon carcinogenesis via suppression of multiple signal transduction pathways in azoxymethane-treated mice.
Topics: Animals; Azoxymethane; Colon; Colonic Neoplasms; Disease Models, Animal; Down-Regulation; Humans; Male; Mice; Mice, Inbred ICR; Signal Transduction; Stilbenes | 2010 |
Novel phthalide compounds from Sparassis crispa (Hanabiratake), Hanabiratakelide A-C, exhibiting anti-cancer related activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Antioxidants; Azoxymethane; Benzofurans; Caco-2 Cells; Cell Proliferation; Colonic Neoplasms; Dinoprostone; Dose-Response Relationship, Drug; Female; Humans; Macrophages; Magnetic Resonance Spectroscopy; Mice; Molecular Structure; Nitric Oxide; Polyporales; Rats; Rats, Inbred F344; Superoxide Dismutase | 2010 |
Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase.
Topics: Adamantane; Animals; Azoxymethane; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Extracellular Signal-Regulated MAP Kinases; Lysophospholipids; Mice; Mice, Inbred C57BL; Phosphotransferases (Alcohol Group Acceptor); Proto-Oncogene Proteins c-akt; Pyridines; Sphingosine | 2010 |
Chemoprevention of colonic tumorigenesis by dietary hydroxylated polymethoxyflavones in azoxymethane-treated mice.
Topics: Aberrant Crypt Foci; Adenoma; Animals; Apoptosis; Azoxymethane; Carcinogens; Citrus sinensis; Colon; Colonic Neoplasms; Cyclooxygenase 2; Diet; Flavones; Fruit; Gene Expression Regulation, Neoplastic; Male; Mice; Mice, Inbred ICR; Nitric Oxide Synthase Type II; Random Allocation; RNA, Messenger; Signal Transduction; Time Factors | 2011 |
Mechanistic insight into the ability of American ginseng to suppress colon cancer associated with colitis.
Topics: Adaptor Proteins, Signal Transducing; Animals; Azoxymethane; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Female; HSP90 Heat-Shock Proteins; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 7; Panax; PAX2 Transcription Factor; Phytotherapy; Plant Extracts | 2010 |
Inhibitory effect of silibinin against azoxymethane-induced colon tumorigenesis in A/J mice.
Topics: Angiogenic Proteins; Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Azoxymethane; Carcinogens; Carcinoma; Cell Proliferation; Colonic Neoplasms; Cytoprotection; Dose-Response Relationship, Drug; Down-Regulation; Drug Evaluation, Preclinical; Inflammation Mediators; Male; Mice; Mice, Inbred Strains; Silybin; Silymarin | 2010 |
Immunomodulatory effects of Withania somnifera on azoxymethane induced experimental colon cancer in mice.
Topics: Aberrant Crypt Foci; Animals; Azoxymethane; Colon; Colonic Neoplasms; Immunocompetence; Immunoglobulins; Immunomodulation; Mice; Neoplasms, Experimental; Plant Extracts; Plant Roots; Withania | 2010 |
Kenaf seed supercritical fluid extract reduces aberrant crypt foci formation in azoxymethane-induced rats.
Topics: Aberrant Crypt Foci; Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Hibiscus; Male; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; Seeds | 2012 |
The NSAID sulindac is chemopreventive in the mouse distal colon but carcinogenic in the proximal colon.
Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Drug Evaluation, Preclinical; Gene Expression Regulation; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation Mediators; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Mice, Knockout; MutS Homolog 2 Protein; Precancerous Conditions; Sulindac; Tumor Suppressor Protein p53 | 2011 |
Western-style diets induce macrophage infiltration and contribute to colitis-associated carcinogenesis.
Topics: Animals; Azoxymethane; beta Catenin; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Dextran Sulfate; Diet; Dinoprostone; Disease Susceptibility; Hydroxyprostaglandin Dehydrogenases; Macrophages; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Signal Transduction; Statistics, Nonparametric; Tumor Necrosis Factor-alpha | 2010 |
In vivo analysis of mouse gastrin gene regulation in enhanced GFP-BAC transgenic mice.
Topics: Aging; Animals; Azoxymethane; Carcinogens; Chromosomes, Artificial, Bacterial; Colonic Neoplasms; Dextran Sulfate; Down-Regulation; Fasting; Fetus; Gastric Acid; Gastrin-Secreting Cells; Gastrins; Gene Expression Regulation, Developmental; Genes, Reporter; Green Fluorescent Proteins; Helicobacter felis; Helicobacter Infections; Mice; Mice, Transgenic; Pyloric Antrum; Somatostatin; Tissue Distribution; Transcription, Genetic; Transgenes; Up-Regulation | 2011 |
Mthfd1 is a modifier of chemically induced intestinal carcinogenesis.
Topics: Aminohydrolases; Animals; Apoptosis; Azoxymethane; Biomarkers, Tumor; Blotting, Western; Carcinogens; Cell Proliferation; Colonic Neoplasms; Disease Models, Animal; DNA, Neoplasm; Female; Formate-Tetrahydrofolate Ligase; Gene Expression Profiling; Immunoenzyme Techniques; Male; Methenyltetrahydrofolate Cyclohydrolase; Methylenetetrahydrofolate Dehydrogenase (NADP); Mice; Mice, Inbred C57BL; Mice, Knockout; Multienzyme Complexes; Multifunctional Enzymes; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Uracil | 2011 |
Involvement of p21cip1/waf1 in the anti-proliferative effects of polyethylene glycol in colon carcinogenesis.
Topics: Animals; Azoxymethane; Blotting, Western; Carcinogens; Cell Proliferation; Colon; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; G1 Phase; HT29 Cells; Humans; Male; Polyethylene Glycols; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; S Phase; Surface-Active Agents | 2011 |
Chemopreventive effects of dietary canola oil on colon cancer development.
Topics: Animals; Azoxymethane; Chemoprevention; Colon; Colonic Neoplasms; Corn Oil; Cyclooxygenase 2; Diet; Dietary Fats; Dietary Supplements; Fatty Acids, Monounsaturated; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Linseed Oil; Male; Rapeseed Oil; Rats; Rats, Inbred F344 | 2011 |
Is the tissue persistence of O(6)-methyl-2'-deoxyguanosine an indicator of tumour formation in the gastrointestinal tract?
Topics: Alkylating Agents; Animals; Azoxymethane; Colonic Neoplasms; Deoxyguanosine; DNA Adducts; Gastrointestinal Tract; Intestinal Neoplasms; Intestine, Small; Male; Methylation; Mutagens; Rats; Rats, Sprague-Dawley; Time Factors | 2011 |
MTGR1 is required for tumorigenesis in the murine AOM/DSS colitis-associated carcinoma model.
Topics: Animals; Azoxymethane; Carcinoma; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Disease Progression; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Repressor Proteins | 2011 |
Pterostilbene is more potent than resveratrol in preventing azoxymethane (AOM)-induced colon tumorigenesis via activation of the NF-E2-related factor 2 (Nrf2)-mediated antioxidant signaling pathway.
Topics: Animals; Antioxidants; Azoxymethane; Colonic Neoplasms; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Mice, Inbred BALB C; NF-E2-Related Factor 2; Resveratrol; Signal Transduction; Stilbenes | 2011 |
Chemoprevention of azoxymethane/dextran sodium sulfate-induced mouse colon carcinogenesis by freeze-dried yam sanyaku and its constituent diosgenin.
Topics: Animals; Azoxymethane; Biomarkers, Tumor; Carcinogens; Colonic Neoplasms; Dextran Sulfate; Dioscorea; Diosgenin; Disease Models, Animal; Gene Expression Profiling; Male; Mice; Mice, Inbred ICR; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2011 |
Study of the antineoplastic action of Tabebuia avellanedae in carcinogenesis induced by azoxymethane in mice.
Topics: Animals; Antineoplastic Agents, Phytogenic; Azoxymethane; Carcinogens; Colonic Neoplasms; Male; Mice; Plant Extracts; Tabebuia | 2011 |
Application of near-infrared fluorescence imaging using a polymeric nanoparticle-based probe for the diagnosis and therapeutic monitoring of colon cancer.
Topics: Adenocarcinoma; Animals; Azoxymethane; Cell Line, Tumor; Colon; Colonic Neoplasms; Diagnostic Imaging; Disease Models, Animal; Disease Progression; Drug Therapy; Enzyme Inhibitors; Fluorescent Dyes; Humans; Male; Matrix Metalloproteinase 7; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred Strains; Nanoparticles; Treatment Outcome; Xenograft Model Antitumor Assays | 2011 |
Neo-angiogenesis and the premalignant micro-circulatory augmentation of early colon carcinogenesis.
Topics: Adenoma; Animals; Azoxymethane; Biomarkers, Tumor; Blotting, Western; Carcinogens; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Gene Expression Profiling; Intestinal Mucosa; Neovascularization, Pathologic; Oligonucleotide Array Sequence Analysis; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2011 |
Green tea, phytic acid, and inositol in combination reduced the incidence of azoxymethane-induced colon tumors in Fisher 344 male rats.
Topics: Administration, Oral; Animals; Anticarcinogenic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione Transferase; Inositol; Male; Phytic Acid; Phytotherapy; Plant Extracts; Rats; Rats, Inbred F344; Tea | 2011 |
A chemoprotective fish oil- and pectin-containing diet temporally alters gene expression profiles in exfoliated rat colonocytes throughout oncogenesis.
Topics: Animals; Azoxymethane; Cell Cycle; Cell Proliferation; Colonic Neoplasms; Diet; Dietary Fats, Unsaturated; Dietary Sucrose; Enterocytes; Feces; Fish Oils; Gene Expression Profiling; Male; Oligonucleotide Array Sequence Analysis; Pectins; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2011 |
Effects of diet-induced obesity on colitis-associated colon tumor formation in A/J mice.
Topics: Animals; Azoxymethane; Blotting, Western; Carcinogens; Colitis; Colon; Colonic Neoplasms; Diet, High-Fat; Disease Models, Animal; Male; Mice; Obesity; Signal Transduction | 2012 |
Pharmacological inhibition of Mdm2 triggers growth arrest and promotes DNA breakage in mouse colon tumors and human colon cancer cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Azoxymethane; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; DNA Damage; Doxorubicin; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Imidazoles; Mice; Neoplasms, Experimental; Piperazines; Proto-Oncogene Proteins c-mdm2; Tumor Suppressor Protein p53 | 2012 |
Selective PGE(2) suppression inhibits colon carcinogenesis and modifies local mucosal immunity.
Topics: Animals; Anticarcinogenic Agents; Arachidonic Acid; Azoxymethane; Colonic Neoplasms; Dinoprostone; Gene Deletion; Immunity, Mucosal; Intramolecular Oxidoreductases; Lymph Nodes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microsomes; Prostaglandin-E Synthases | 2011 |
Mustard seeds (Sinapis Alba Linn) attenuate azoxymethane-induced colon carcinogenesis.
Topics: 3T3 Cells; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Azoxymethane; Caspase 3; Catalase; Cell Line, Tumor; Cell Proliferation; Colon; Colonic Neoplasms; Humans; Lipid Peroxidation; Malondialdehyde; Mice; Phytotherapy; Plant Extracts; Reactive Oxygen Species; Seeds; Sinapis; Superoxide Dismutase | 2011 |
Dietary astaxanthin inhibits colitis and colitis-associated colon carcinogenesis in mice via modulation of the inflammatory cytokines.
Topics: Adenocarcinoma; Animals; Apoptosis; Azoxymethane; Colitis; Colonic Neoplasms; Cyclooxygenase 2; Cytokines; Dextran Sulfate; Dietary Supplements; Interleukin-1beta; Interleukin-6; Male; Mice; Mice, Inbred ICR; NF-kappa B; Tumor Necrosis Factor-alpha; Xanthophylls | 2011 |
The neurotensin receptor-1 promotes tumor development in a sporadic but not an inflammation-associated mouse model of colon cancer.
Topics: Animals; Azoxymethane; Chemokine CXCL2; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Female; Gene Expression; Humans; Immunohistochemistry; Interleukin-6; Kaplan-Meier Estimate; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Pyrazoles; Quinolines; Receptors, Neurotensin; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tumor Necrosis Factor-alpha | 2012 |
Renin-angiotensin system inhibitors suppress azoxymethane-induced colonic preneoplastic lesions in C57BL/KsJ-db/db obese mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Azoxymethane; Benzimidazoles; Benzoates; Captopril; Colonic Neoplasms; Cyclooxygenase 2; Deoxyguanosine; Interleukin-1beta; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Obesity; Oxidative Stress; Plasminogen Activator Inhibitor 1; Precancerous Conditions; Renin-Angiotensin System; RNA, Messenger; Telmisartan; Tumor Necrosis Factor-alpha | 2011 |
EGFR signals downregulate tumor suppressors miR-143 and miR-145 in Western diet-promoted murine colon cancer: role of G1 regulators.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Azoxymethane; Cetuximab; Colitis, Ulcerative; Colonic Neoplasms; Dextran Sulfate; Diet; Down-Regulation; ErbB Receptors; G1 Phase; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; HCT116 Cells; Humans; Mice; MicroRNAs; Neoplasms, Experimental; Rats; Signal Transduction | 2011 |
Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis-associated tumorigenesis.
Topics: Animals; Azoxymethane; Blotting, Western; Carcinogens; Colitis, Ulcerative; Colonic Neoplasms; Dextran Sulfate; Enzyme-Linked Immunosorbent Assay; Humans; Immunoenzyme Techniques; Inflammation; Inflammation Mediators; Intestinal Mucosa; Mice; Mice, Transgenic; Microfilament Proteins; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Toll-Like Receptor 4 | 2011 |
Dynamics of claudins expression in colitis and colitis-associated cancer in rat.
Topics: Animals; Azoxymethane; Blotting, Western; Busulfan; Claudins; Colitis; Colonic Neoplasms; Dextran Sulfate; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Gene Expression Profiling; Gene Expression Regulation; Immunoblotting; Microscopy, Fluorescence; Rats; Tight Junctions | 2011 |
1'-Acetoxychavicol acetate enhances the phase II enzyme activities via the increase in intranuclear Nrf2 level and cytosolic p21 level.
Topics: Alpinia; Animals; Antineoplastic Agents, Phytogenic; Azoxymethane; Benzyl Alcohols; Cell Line; Cell Proliferation; Colon; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Enzyme Activation; Epithelial Cells; Glutathione; Glutathione Transferase; Intestinal Mucosa; Metabolic Detoxication, Phase II; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Plant Extracts; Rats | 2011 |
Notch1 regulates the effects of matrix metalloproteinase-9 on colitis-associated cancer in mice.
Topics: Amyloid Precursor Protein Secretases; Animals; Apoptosis; Azoxymethane; Caspase 3; Colitis; Colon; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cytokines; Dextran Sulfate; Dipeptides; Disease Models, Animal; DNA Damage; Enzyme Inhibitors; Fibroblasts; Gamma Rays; HCT116 Cells; Humans; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptor, Notch1; RNA, Messenger; Signal Transduction; Time Factors; Transfection; Tumor Suppressor Protein p53 | 2011 |
Disruption of the mouse protein tyrosine kinase 6 gene prevents STAT3 activation and confers resistance to azoxymethane.
Topics: Aberrant Crypt Foci; Animals; Apoptosis; Azoxymethane; Carcinogens; Cell Proliferation; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; HCT116 Cells; Humans; Immunoblotting; Immunohistochemistry; Mice; Mice, Knockout; Neoplasm Proteins; Phosphorylation; Protein-Tyrosine Kinases; RNA Interference; Signal Transduction; src-Family Kinases; STAT3 Transcription Factor; Time Factors | 2011 |
Combination of atorvastatin with sulindac or naproxen profoundly inhibits colonic adenocarcinomas by suppressing the p65/β-catenin/cyclin D1 signaling pathway in rats.
Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticholesteremic Agents; Antineoplastic Combined Chemotherapy Protocols; Atorvastatin; Azoxymethane; beta Catenin; Carcinogens; Colonic Neoplasms; Cyclin D1; eIF-2 Kinase; Enzyme-Linked Immunosorbent Assay; Heptanoic Acids; Immunoenzyme Techniques; Interleukin-4; Male; Naproxen; Nitric Oxide Synthase Type II; Pyrroles; Rats; Rats, Inbred F344; Signal Transduction; Sulindac; Tumor Necrosis Factor-alpha | 2011 |
Dietary folate protects against azoxymethane-induced aberrant crypt foci development and oxidative stress in rat colon.
Topics: Aberrant Crypt Foci; Animals; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Dietary Supplements; Dose-Response Relationship, Drug; Folic Acid; Glutathione; Male; Oxidative Stress; Rats | 2011 |
Non-digestible fraction of cooked bean (Phaseolus vulgaris L.) cultivar Bayo Madero suppresses colonic aberrant crypt foci in azoxymethane-induced rats.
Topics: Animal Feed; Animals; Azoxymethane; Colon; Colonic Neoplasms; Cooking; Cytoprotection; Dietary Carbohydrates; Dietary Fiber; Digestion; Disease Models, Animal; Eating; Fatty Acids, Volatile; Feces; Intestinal Mucosa; Male; Phaseolus; Plant Proteins, Dietary; Rats; Rats, Sprague-Dawley; Solubility | 2010 |
Inhibition of azoxymethane-induced preneoplastic lesions in the rat colon by a cooked stearic acid complexed high-amylose cornstarch.
Topics: Amylose; Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Diet; Fatty Acids, Volatile; Hot Temperature; Male; Precancerous Conditions; Rats; Rats, Inbred F344; Starch; Stearic Acids | 2011 |
Anticlastogenic and anticarcinogenic potential of Thai bitter gourd fruits.
Topics: Animals; Anticarcinogenic Agents; Antimutagenic Agents; Antineoplastic Agents; Azoxymethane; Benz(a)Anthracenes; Colonic Neoplasms; Cyclophosphamide; Female; Male; Mice; Mice, Inbred ICR; Micronucleus Tests; Momordica charantia; Mutagens; Plant Extracts; Rats; Rats, Sprague-Dawley; Reticulocytes | 2011 |
Tetrahydrocurcumin is more effective than curcumin in preventing azoxymethane-induced colon carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; beta Catenin; Blotting, Western; Colon; Colonic Neoplasms; Curcumin; Down-Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Male; Mice; Mice, Inbred ICR; Phosphorylation; Wnt1 Protein | 2011 |
Chemoprevention of colon cancer in a rat carcinogenesis model using a novel nanotechnology-based combined treatment system.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Combined Chemotherapy Protocols; Aspirin; Azoxymethane; Cell Proliferation; Colonic Neoplasms; Disease Models, Animal; Drug Delivery Systems; Folic Acid; Lactic Acid; Male; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Vitamin B Complex | 2011 |
Cocoa-rich diet prevents azoxymethane-induced colonic preneoplastic lesions in rats by restraining oxidative stress and cell proliferation and inducing apoptosis.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; bcl-2-Associated X Protein; Cacao; Caspase 3; Cell Proliferation; Colon; Colonic Neoplasms; Cyclin D1; Diet; Gene Expression Regulation; Oxidative Stress; Precancerous Conditions; Rats | 2011 |
Anti-carcinogenic properties of omeprazole against human colon cancer cells and azoxymethane-induced colonic aberrant crypt foci formation in rats.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Cell Growth Processes; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; HCT116 Cells; Humans; Male; Omeprazole; Precancerous Conditions; Random Allocation; Rats; Rats, Inbred F344 | 2012 |
Microsomal prostaglandin E synthase-1 is involved in multiple steps of colon carcinogenesis.
Topics: Aberrant Crypt Foci; Adenocarcinoma; Animals; Azoxymethane; beta Catenin; Carcinogens; Cell Transformation, Neoplastic; Coculture Techniques; Colonic Neoplasms; Colonic Polyps; Cytokines; Gene Expression Profiling; Intramolecular Oxidoreductases; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Microsomes; Neoplasm Transplantation; Prostaglandin-E Synthases; Prostaglandins | 2012 |
Involvement of interleukin-21 in the regulation of colitis-associated colon cancer.
Topics: Animals; Azoxymethane; Carcinogens; CD4-Positive T-Lymphocytes; Cell Line, Tumor; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Forkhead Transcription Factors; Humans; Interleukin-17; Interleukin-6; Interleukins; Mice; Mice, Inbred C57BL; Mice, Knockout; STAT3 Transcription Factor | 2011 |
Chronic psychosocial stress increases the risk for inflammation-related colon carcinogenesis in male mice.
Topics: Animals; Azoxymethane; Colitis; Colon; Colonic Neoplasms; Colorectal Neoplasms; Cyclooxygenase 2; Dextran Sulfate; Housing, Animal; Inflammation; Interferon-gamma; Male; Mice; Mice, Inbred C57BL; Social Dominance; Stress, Psychological | 2012 |
Butyrate delivered by butyrylated starch increases distal colonic epithelial apoptosis in carcinogen-treated rats.
Topics: Animals; Apoptosis; Azoxymethane; Butyrates; Caspase 3; Cell Proliferation; Colonic Neoplasms; Fatty Acids, Volatile; Intestinal Mucosa; Male; Rats; Rats, Sprague-Dawley; Starch | 2012 |
Effects of S-adenosylmethionine and methylthioadenosine on inflammation-induced colon cancer in mice.
Topics: Animals; Apoptosis; Azoxymethane; beta Catenin; Cell Proliferation; Cell Transformation, Neoplastic; Chemoprevention; Colonic Neoplasms; Dextran Sulfate; Inflammation; Interleukin-10; Interleukin-6; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Nitric Oxide Synthase Type II; Proto-Oncogene Proteins c-akt; Purine-Nucleoside Phosphorylase; S-Adenosylhomocysteine; S-Adenosylmethionine; Signal Transduction; STAT3 Transcription Factor; Transcriptional Activation; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2012 |
Preventive effects of curcumin on the development of azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db obese mice.
Topics: Adiponectin; Adipose Tissue; AMP-Activated Protein Kinase Kinases; Animals; Anticarcinogenic Agents; Azoxymethane; Colon; Colonic Neoplasms; Curcumin; Cyclooxygenase 2; Dietary Supplements; Interleukin-6; Intestinal Mucosa; Leptin; Male; Mice; Mice, Inbred C57BL; Mice, Obese; NF-kappa B; Obesity; Organ Size; Precancerous Conditions; Protein Kinases; Tumor Necrosis Factor-alpha | 2012 |
Glutathione peroxidase-2 and selenium decreased inflammation and tumors in a mouse model of inflammation-associated carcinogenesis whereas sulforaphane effects differed with selenium supply.
Topics: Animals; Apoptosis; Azoxymethane; Cell Transformation, Neoplastic; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Glutathione Peroxidase; Glutathione Transferase; Ileum; Inflammation; Isothiocyanates; Mice; Mice, Inbred C57BL; Mice, Knockout; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Selenium; Sulfoxides; Thiocyanates; Thioredoxin-Disulfide Reductase | 2012 |
Differential CD133 expression pattern during mouse colon tumorigenesis.
Topics: AC133 Antigen; Animals; Antigens, CD; Azoxymethane; Carcinogens; Cell Line, Tumor; Colon; Colonic Neoplasms; Dextran Sulfate; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glycoproteins; Mice; Mutation; Neoplastic Stem Cells; Peptides | 2011 |
Monosodium glutamate-induced diabetic mice are susceptible to azoxymethane-induced colon tumorigenesis.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Diabetes Mellitus, Experimental; Disease Models, Animal; Disease Susceptibility; Hypercholesterolemia; Hyperglycemia; Hyperinsulinism; Insulin-Like Growth Factor I; Male; Mice; Mice, Inbred ICR; Precancerous Conditions; Receptor, IGF Type 1; RNA, Messenger; Sodium Glutamate | 2012 |
Dietary calcium supplementation enhances efficacy but also toxicity of EGFR inhibitor therapy for colon cancer.
Topics: Animals; Antineoplastic Agents; Azoxymethane; Calcium; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colonic Neoplasms; Dietary Supplements; Drug Screening Assays, Antitumor; Drug Synergism; ErbB Receptors; Female; Humans; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Quinazolines; Random Allocation; Tumor Burden; Tyrphostins | 2012 |
Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer.
Topics: Animals; Antineoplastic Agents; Azoxymethane; Caco-2 Cells; Cannabidiol; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Comet Assay; HCT116 Cells; Humans; Male; Mice; Mice, Inbred ICR | 2012 |
The formation of azoxymethane, a colon carcinogen, during the chemical oxidation of methylamine.
Topics: Azoxymethane; Carcinogens; Chromatography, High Pressure Liquid; Colonic Neoplasms; Gas Chromatography-Mass Spectrometry; Humans; Methanol; Methylamines; Oxidation-Reduction; Oxygen; Polarography | 1980 |
Optical imaging of MMP expression and cancer progression in an inflammation-induced colon cancer model.
Topics: Animals; Azoxymethane; beta Catenin; Blotting, Western; Carbocyanines; Carcinogens; Colonic Neoplasms; Dextran Sulfate; Diagnostic Imaging; Disease Models, Animal; Disease Progression; Immunoenzyme Techniques; Inflammation; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Peptide Fragments | 2012 |
Induction of colonic aberrant crypts in mice by feeding apparent N-nitroso compounds derived from hot dogs.
Topics: Aberrant Crypt Foci; Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Feces; Female; Food Handling; Meat Products; Mice; Nitrosation; Nitroso Compounds; Sodium Nitrite | 2012 |
Suppression of azoxymethane-induced colonic preneoplastic lesions in rats by 1-methyltryptophan, an inhibitor of indoleamine 2,3-dioxygenase.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Carcinogens; Colonic Neoplasms; Indoleamine-Pyrrole 2,3,-Dioxygenase; Male; Precancerous Conditions; Rats; Rats, Inbred F344; Tryptophan | 2012 |
Glucagon-like peptide-2 increases dysplasia in rodent models of colon cancer.
Topics: Animals; Azoxymethane; beta Catenin; Blotting, Western; Carcinogens; Colitis; Colonic Neoplasms; Dextran Sulfate; Diet, High-Fat; Doublecortin Protein; Glucagon-Like Peptide 2; Imidazoles; Immunohistochemistry; Inflammation; Male; Mice; Mice, Inbred C57BL; Rats; Rats, Inbred F344; Real-Time Polymerase Chain Reaction; RNA, Messenger | 2012 |
δ- and γ-tocopherols, but not α-tocopherol, inhibit colon carcinogenesis in azoxymethane-treated F344 rats.
Topics: Aldehydes; alpha-Tocopherol; Animals; Anticarcinogenic Agents; Azoxymethane; Colonic Neoplasms; Cyclin D1; Dinoprost; Dinoprostone; gamma-Tocopherol; Immunohistochemistry; Male; Models, Chemical; Rats; Rats, Inbred F344; Tocopherols; Tyrosine | 2012 |
Whey protein versus whey protein hydrolyzate for the protection of azoxymethane and dextran sodium sulfate induced colonic tumors in rats.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Dextran Sulfate; Histocytochemistry; Male; Milk Proteins; Protective Agents; Protein Hydrolysates; Rats; Rats, Wistar; Statistics, Nonparametric; Weight Loss; Whey Proteins | 2012 |
Suppressive effects of Moringa oleifera Lam pod against mouse colon carcinogenesis induced by azoxymethane and dextran sodium sulfate.
Topics: Animals; Azoxymethane; Carcinogens; Colitis; Colonic Neoplasms; Cyclooxygenase 2; Dextran Sulfate; Immunoenzyme Techniques; Male; Mice; Mice, Inbred ICR; Moringa oleifera; Nitric Oxide Synthase Type II; Phytotherapy; Plant Extracts | 2011 |
Effects of gut-targeted 15-LOX-1 transgene expression on colonic tumorigenesis in mice.
Topics: Animals; Arachidonate 15-Lipoxygenase; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Disease Models, Animal; Epithelial Cells; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Immunoblotting; Intestinal Mucosa; Mice; Mice, Transgenic; NF-kappa B; Nitric Oxide Synthase Type II; Real-Time Polymerase Chain Reaction; RNA, Messenger; Transgenes; Tumor Necrosis Factor-alpha; Up-Regulation | 2012 |
P53 gene mutation increases progastrin dependent colonic proliferation and colon cancer formation in mice.
Topics: Aberrant Crypt Foci; Animals; Azoxymethane; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; Colonic Neoplasms; Disease Models, Animal; Female; Gastrins; Humans; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Protein Precursors; Tumor Suppressor Protein p53 | 2012 |
Regulation of colon gene expression by vitamin B6 supplementation.
Topics: Aberrant Crypt Foci; Animals; Azoxymethane; CD8 Antigens; Cell Proliferation; Chemokine CCL8; Colon; Colonic Neoplasms; Dietary Supplements; Down-Regulation; Gene Expression Regulation, Neoplastic; Male; Mice; Mice, Inbred ICR; Oligonucleotide Array Sequence Analysis; RNA, Messenger; Vitamin B 6 | 2012 |
IEX-1 deficiency protects against colonic cancer.
Topics: Animals; Apoptosis; Azoxymethane; Cell Proliferation; Colitis; Colon; Colonic Neoplasms; Cytokines; Dextran Sulfate; Epithelial Cells; Female; Gene Expression; GTP-Binding Protein alpha Subunit, Gi2; Immediate-Early Proteins; Intestinal Mucosa; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Reverse Transcriptase Polymerase Chain Reaction; Th17 Cells | 2012 |
In vivo measurement of the shape of the tissue-refractive-index correlation function and its application to detection of colorectal field carcinogenesis.
Topics: Algorithms; Animals; Azoxymethane; Case-Control Studies; Colonic Neoplasms; Colonoscopy; Male; Monte Carlo Method; Neoplasms, Experimental; Rats; Rats, Inbred F344; Refractometry; Spectrum Analysis | 2012 |
RETRACTED: Obesity-induced increase in tumor necrosis factor-α leads to development of colon cancer in mice.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Apoptosis; Azoxymethane; Blotting, Western; Cell Proliferation; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Enzyme Activation; HT29 Cells; Humans; Hyperinsulinism; Hypoglycemic Agents; I-kappa B Kinase; Immunohistochemistry; Inflammation Mediators; Infliximab; Insulin; JNK Mitogen-Activated Protein Kinases; Male; Mice; Mice, Inbred C57BL; Mice, SCID; Obesity; Phosphatidylinositol 3-Kinase; Pioglitazone; Proto-Oncogene Proteins c-akt; Signal Transduction; Thiazolidinediones; Time Factors; TOR Serine-Threonine Kinases; Tumor Burden; Tumor Necrosis Factor-alpha; Up-Regulation; Xenograft Model Antitumor Assays | 2012 |
Chemoprevention of azoxymethane-initiated colon cancer in rat by using a novel polymeric nanocarrier--curcumin.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Chemoprevention; Colonic Neoplasms; Curcumin; Drug Carriers; Male; Nanoparticles; Polymers; Rats; Rats, Wistar | 2012 |
Genistein, a soya isoflavone, prevents azoxymethane-induced up-regulation of WNT/β-catenin signalling and reduces colon pre-neoplasia in rats.
Topics: Aberrant Crypt Foci; Animals; Azoxymethane; Biomarkers; Carcinogens; Colon, Descending; Colonic Neoplasms; Cyclin D1; Disease Models, Animal; Down-Regulation; Female; Genistein; Lactation; Male; Maternal Nutritional Physiological Phenomena; Precancerous Conditions; Pregnancy; Proto-Oncogene Proteins c-myc; Rats; Rats, Sprague-Dawley; Soybean Proteins; Wnt Signaling Pathway | 2013 |
Deleterious effects of high concentrations of (-)-epigallocatechin-3-gallate and atorvastatin in mice with colon inflammation.
Topics: Animals; Atorvastatin; Azoxymethane; Catechin; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Gastrointestinal Hemorrhage; Heptanoic Acids; Leukotriene B4; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Pyrroles; Rectum; Weight Loss | 2012 |
Silibinin, a natural flavonoid, modulates the early expression of chemoprevention biomarkers in a preclinical model of colon carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Apoptosis; Azoxymethane; Biomarkers, Tumor; Caspase 3; Cell Transformation, Neoplastic; Colonic Neoplasms; Down-Regulation; Interleukin-1beta; Intestinal Mucosa; Male; Matrix Metalloproteinase 7; Plant Extracts; Proto-Oncogene Proteins c-bcl-2; Random Allocation; Rats; Rats, Wistar; RNA, Messenger; Silybin; Silybum marianum; Silymarin; Tumor Necrosis Factor-alpha | 2012 |
Effect of luteolin on the levels of glycoproteins during azoxymethane-induced colon carcinogenesis in mice.
Topics: Aberrant Crypt Foci; Analysis of Variance; Animals; Anticarcinogenic Agents; Azoxymethane; Colon; Colonic Neoplasms; Fucose; Glycoconjugates; Glycoproteins; Hexosamines; Hexoses; Lipid Peroxidation; Luteolin; Male; Malondialdehyde; Mice; Mice, Inbred BALB C; Mucins; Mucoproteins; N-Acetylneuraminic Acid; Protein Carbonylation | 2012 |
Reduced susceptibility to colitis-associated colon carcinogenesis in mice lacking plasma membrane-associated sialidase.
Topics: Animals; Azoxymethane; Cell Membrane; Colitis; Colonic Neoplasms; Dextrans; Gangliosides; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Genetic Vectors; Genotype; Glycoconjugates; Glycolipids; Mice; Mice, Transgenic; Neuraminidase; Sialic Acids; Sulfates | 2012 |
Deletion of p38-alpha mitogen-activated protein kinase within the intestinal epithelium promotes colon tumorigenesis.
Topics: Adenoma; Animals; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Enterocytes; Feces; Intestinal Mucosa; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 14; Weight Loss | 2012 |
Non-digestible fraction of beans (Phaseolus vulgaris L.) modulates signalling pathway genes at an early stage of colon cancer in Sprague-Dawley rats.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Cell Cycle; Colon; Colonic Neoplasms; Diet; Dietary Fiber; Digestion; DNA Repair; Gene Expression; Gene Expression Profiling; Male; Phaseolus; Plant Extracts; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Seeds; Signal Transduction | 2012 |
Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Adenoma; Animals; Animals, Inbred Strains; Azoxymethane; Cell Transformation, Neoplastic; Chemokines, CXC; Colitis; Colonic Neoplasms; Dermatitis, Contact; Dextran Sulfate; Gene Expression; Mice; Mice, 129 Strain; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Papilloma; Peroxidase; Precancerous Conditions; Receptors, Interleukin-8B; Skin Neoplasms; Statistics, Nonparametric; Tetradecanoylphorbol Acetate; Tumor Burden | 2012 |
Modeling colitis-associated cancer with azoxymethane (AOM) and dextran sulfate sodium (DSS).
Topics: Animals; Azoxymethane; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Female; Male; Mice | 2012 |
Dietary folate does not significantly affect the intestinal microbiome, inflammation or tumorigenesis in azoxymethane-dextran sodium sulphate-treated mice.
Topics: Animals; Azoxymethane; Biomarkers; Colitis, Ulcerative; Colon; Colonic Neoplasms; Dextran Sulfate; Dextrans; Diet; Disease Progression; Folic Acid; Inflammation; Male; Mice; Mice, Inbred C57BL; Microbiota; Neoplasms; RNA, Ribosomal, 16S; Sulfates | 2013 |
Use of a chemically induced-colon carcinogenesis-prone Apc-mutant rat in a chemotherapeutic bioassay.
Topics: Adenocarcinoma; Adenomatous Polyposis Coli Protein; Animals; Antimetabolites, Antineoplastic; Azoxymethane; Colon; Colonic Neoplasms; Dextran Sulfate; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Screening Assays, Antitumor; Fluorouracil; Injections, Intravenous; Male; Mutation; Rats; Reproducibility of Results | 2012 |
Mice that express human interleukin-8 have increased mobilization of immature myeloid cells, which exacerbates inflammation and accelerates colon carcinogenesis.
Topics: Animals; Azoxymethane; Cell Line, Tumor; Cell Movement; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Dendritic Cells; Dextran Sulfate; Gastritis; Helicobacter felis; Helicobacter Infections; Humans; Interleukin-8; Lipopolysaccharides; Macrophages; Mice; Mice, Transgenic; Myeloid Cells; Primary Cell Culture; RNA, Messenger; Tumor Burden; Up-Regulation | 2013 |
Dysregulation of microRNAs in colonic field carcinogenesis: implications for screening.
Topics: Animals; Area Under Curve; Azoxymethane; Biomarkers, Tumor; Biopsy; Carcinogens; Carcinoma; Colonic Neoplasms; Down-Regulation; Early Detection of Cancer; Feces; Humans; Intestinal Mucosa; Male; MicroRNAs; Predictive Value of Tests; Rats; Up-Regulation | 2012 |
Pomegranate (Punica granatum) peel extract efficacy as a dietary antioxidant against azoxymethane-induced colon cancer in rat.
Topics: Aberrant Crypt Foci; Animals; Antioxidants; Azoxymethane; Body Weight; Carcinogens; Colonic Neoplasms; Humans; Intestinal Mucosa; Lythraceae; Male; Oxidative Stress; Phytotherapy; Prognosis; Rats; Rats, Sprague-Dawley; Tumor Cells, Cultured | 2012 |
Organomagnesium suppresses inflammation-associated colon carcinogenesis in male Crj: CD-1 mice.
Topics: Adenocarcinoma; Adenoma; Animals; Apoptosis; Azoxymethane; Blotting, Western; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Dextran Sulfate; Humans; Immunoenzyme Techniques; Inflammation; Interferon-gamma; Interleukin-1beta; Interleukin-6; Magnesium Compounds; Male; Mice; Mice, Inbred ICR; Mitotic Index; Organometallic Compounds; Real-Time Polymerase Chain Reaction; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured | 2013 |
Studies on the chemopreventive effect of carnitine on tumorigenesis in vivo, using two experimental murine models of colon cancer.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Carnitine; Carnitine O-Acetyltransferase; Cell Transformation, Neoplastic; Colonic Neoplasms; Diet; Disease Models, Animal; Genes, APC; Intestines; Male; Mice; Mice, Inbred C57BL; Mutation | 2012 |
A polyacetylene-rich extract from Gymnaster koraiensis strongly inhibits colitis-associated colon cancer in mice.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Asteraceae; Azoxymethane; Cell Proliferation; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Inflammation; Liver; Male; Mice; Mice, Inbred C57BL; Plant Extracts; Polyynes | 2013 |
A novel NSAID derivative, phospho-ibuprofen, prevents AOM-induced colon cancer in rats.
Topics: Aberrant Crypt Foci; Animals; Anticarcinogenic Agents; Azoxymethane; beta Catenin; Carcinogens; Colonic Neoplasms; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Ibuprofen; Neoplasms, Experimental; NF-kappa B; Organophosphates; Rats | 2013 |
Effective suppression of azoxymethane-induced aberrant crypt foci formation in mice with citrus peel flavonoids.
Topics: Aberrant Crypt Foci; Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Azoxymethane; Citrus; Colonic Neoplasms; Cyclooxygenase 2; Flavonoids; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred ICR; Nitric Oxide Synthase Type II; Ornithine Decarboxylase; Plant Extracts; Vascular Endothelial Growth Factor A | 2013 |
Effects of a water-soluble extract of Ganoderma lucidum mycelia on aberrant crypt foci induced by azoxymethane and small-intestinal injury by 5-FU in F344 rats.
Topics: Aberrant Crypt Foci; Animals; Azoxymethane; Colonic Neoplasms; Culture Media; Fluorouracil; Intestinal Mucosa; Intestine, Small; Male; Mycelium; Rats; Rats, Inbred F344; Reishi; Water | 2013 |
Hesperidin alleviates oxidative stress and downregulates the expressions of proliferative and inflammatory markers in azoxymethane-induced experimental colon carcinogenesis in mice.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Azoxymethane; Biomarkers; Carcinogens; Cell Proliferation; Colonic Neoplasms; Cyclooxygenase 2; Down-Regulation; Hesperidin; Inflammation; Male; Mice; NF-kappa B; Nitric Oxide Synthase Type II; Oxidative Stress; Proliferating Cell Nuclear Antigen | 2013 |
Loss of sulfiredoxin renders mice resistant to azoxymethane/dextran sulfate sodium-induced colon carcinogenesis.
Topics: Animals; Apoptosis; Azoxymethane; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Colonic Neoplasms; Dextran Sulfate; Genotype; Humans; Lung Neoplasms; Macrophages; Mice; Mice, Knockout; Oxidoreductases Acting on Sulfur Group Donors; Peroxiredoxins | 2013 |
Hemizygous mice for the angiotensin II type 2 receptor gene have attenuated susceptibility to azoxymethane-induced colon tumorigenesis.
Topics: Animals; Azoxymethane; Blotting, Western; Carcinogens; Colon; Colonic Neoplasms; Crosses, Genetic; Cytochrome P-450 CYP2E1; DNA Adducts; DNA Primers; Down-Regulation; Endopeptidases; Female; Genotype; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Reverse Transcriptase Polymerase Chain Reaction | 2002 |
Deletion of functional gastrin gene markedly increases colon carcinogenesis in response to azoxymethane in mice.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Female; Gastrins; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Precancerous Conditions | 2002 |
Molecular changes in the early stage of colon carcinogenesis in rats treated with azoxymethane.
Topics: Adenomatous Polyposis Coli Protein; Animals; Apoptosis; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Cyclooxygenase 2; Genes, ras; In Situ Nick-End Labeling; Intestinal Mucosa; Isoenzymes; Male; Nucleolus Organizer Region; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Precancerous Conditions; Prostaglandin-Endoperoxide Synthases; Proto-Oncogene Proteins c-myc; Rats; Rats, Inbred F344; RNA, Messenger | 2002 |
A diet containing alpha-cellulose and fish oil reduces aberrant crypt foci formation and modulates other possible markers for colon cancer risk in azoxymethane-treated rats.
Topics: Animal Feed; Animals; Azoxymethane; Butyrates; Carcinogens; Cecum; Cellulose; Colon; Colonic Neoplasms; Diet; Fish Oils; Intestinal Mucosa; Male; Plant Oils; Rats; Rats, Sprague-Dawley; Regression Analysis; Sunflower Oil | 2002 |
Steady state levels of transforming growth factor-beta1 and -beta2 mRNA and protein expression are elevated in colonic tumors in vivo irrespective of dietary lipids intervention.
Topics: Animals; Azoxymethane; Body Weight; Carcinogens; Cattle; Colonic Neoplasms; Epithelial Cells; Fish Oils; Immunohistochemistry; Lipid Metabolism; Male; Meat; Models, Biological; Phenotype; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Transforming Growth Factor beta; Transforming Growth Factor beta1; Transforming Growth Factor beta2; Up-Regulation; Zea mays | 2002 |
Silymarin, a naturally occurring polyphenolic antioxidant flavonoid, inhibits azoxymethane-induced colon carcinogenesis in male F344 rats.
Topics: Animals; Antioxidants; Azoxymethane; Body Weight; Colonic Neoplasms; Liver; Male; Organ Size; Rats; Rats, Inbred F344; Silymarin | 2002 |
Dietary inulin suppresses azoxymethane-induced preneoplastic aberrant crypt foci in mature Fisher 344 rats.
Topics: Age Factors; Animals; Azoxymethane; Carcinogens; Cecum; Colon; Colonic Neoplasms; Dietary Fiber; Disease Models, Animal; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; Inulin; Male; Organ Size; Precancerous Conditions; Rats; Rats, Inbred F344 | 2002 |
Dietary inulin suppresses azoxymethane-induced aberrant crypt foci and colon tumors at the promotion stage in young Fisher 344 rats.
Topics: Age Factors; Animals; Azoxymethane; Carcinogens; Cecum; Colon; Colonic Neoplasms; Diarrhea; Dietary Fiber; Disease Models, Animal; Hydrogen-Ion Concentration; Intestinal Neoplasms; Intestine, Small; Inulin; Male; Organ Size; Precancerous Conditions; Rats; Rats, Inbred F344; Time Factors | 2002 |
Chemoprevention of precursors to colon cancer by dehydroepiandrosterone (DHEA).
Topics: Adjuvants, Immunologic; Animals; Azoxymethane; beta Catenin; Carcinogens; Chemoprevention; Colonic Neoplasms; Cytoskeletal Proteins; Dehydroepiandrosterone; Diet; Female; Immunoenzyme Techniques; Intestinal Mucosa; Mice; Mice, Inbred BALB C; Precancerous Conditions; Trans-Activators | 2002 |
APC-dependent suppression of colon carcinogenesis by PPARgamma.
Topics: Animals; Azoxymethane; beta Catenin; Carcinogens; Colonic Neoplasms; Cytoskeletal Proteins; Diabetes Mellitus, Type 2; Gene Silencing; Genes, APC; Humans; Hypoglycemic Agents; Male; Mice; Mice, Knockout; Mutation; Receptors, Cytoplasmic and Nuclear; Thiazoles; Trans-Activators; Transcription Factors | 2002 |
Antitumorigenic activity of the prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis on azoxymethane-induced colon carcinogenesis in rats.
Topics: Adenocarcinoma; Adenoma; Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Azoxymethane; Bifidobacterium; Carcinogens; Cecum; Cell Division; Colonic Neoplasms; Cyclooxygenase 2; Diet; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Induction; Fatty Acids, Volatile; Gastrointestinal Contents; Glutathione S-Transferase pi; Glutathione Transferase; Intestinal Mucosa; Inulin; Isoenzymes; Lactobacillus; Male; Neoplasm Proteins; Oligosaccharides; Probiotics; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred F344 | 2002 |
Ursodeoxycholic acid inhibits the initiation and postinitiation phases of azoxymethane-induced colonic tumor development.
Topics: Animals; Azoxymethane; Cholagogues and Choleretics; Colonic Neoplasms; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Incidence; Male; Rats; Rats, Inbred F344; Time Factors; Treatment Outcome; Ursodeoxycholic Acid | 2002 |
Correlation between electron-donating ability of a series of 3-nitroflavones and their efficacy to inhibit the onset and progression of aberrant crypt foci in the rat colon.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Carcinogens; Colonic Neoplasms; Flavonoids; Nitro Compounds; Precancerous Conditions; Rats; Rats, Inbred F344; Reducing Agents; Structure-Activity Relationship | 2002 |
Effects of long-term administration of sulindac on APC mRNA and apoptosis in colons of rats treated with azoxymethane.
Topics: Adenomatous Polyposis Coli Protein; Animals; Apoptosis; Azoxymethane; Colon; Colonic Neoplasms; Cyclooxygenase Inhibitors; In Situ Nick-End Labeling; Intestinal Mucosa; Male; Nucleolus Organizer Region; Precancerous Conditions; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulindac | 2002 |
Preliminary analysis of azoxymethane induced colon tumors in inbred mice commonly used as transgenic/knockout progenitors.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Genetic Predisposition to Disease; Male; Mice; Mice, Inbred AKR; Mice, Inbred BALB C; Mice, Inbred C57BL; Precancerous Conditions; Species Specificity | 2003 |
Simple sugars modulate the development of aberrant crypt foci in rat colon during post-initiation.
Topics: Animals; Azoxymethane; Carcinogens; Cell Division; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Dextrins; Diet; Dietary Sucrose; Male; Malondialdehyde; Oxidation-Reduction; Precancerous Conditions; Random Allocation; Rats; Rats, Inbred F344; Starch | 2002 |
Effect of a propolis extract and caffeic acid phenethyl ester on formation of aberrant crypt foci and tumors in the rat colon.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Caffeic Acids; Colon; Colonic Neoplasms; Male; Phenylethyl Alcohol; Phytotherapy; Plant Extracts; Propolis; Random Allocation; Rats; Rats, Wistar | 2002 |
Ursodeoxycholic acid and F(6)-D(3) inhibit aberrant crypt proliferation in the rat azoxymethane model of colon cancer: roles of cyclin D1 and E-cadherin.
Topics: Animals; Azoxymethane; Base Sequence; Biomarkers, Tumor; Biopsy, Needle; Blotting, Western; Cadherins; Cell Division; Cholecalciferol; Colonic Neoplasms; Cyclin D1; Disease Models, Animal; Immunohistochemistry; Injections, Intraperitoneal; Intestinal Mucosa; Male; Molecular Sequence Data; Neoplasms, Experimental; Polymerase Chain Reaction; Random Allocation; Rats; Rats, Inbred F344; Reference Values; RNA, Messenger; Sensitivity and Specificity; Ursodeoxycholic Acid | 2002 |
Chemopreventive effect of farnesol and lanosterol on colon carcinogenesis.
Topics: Animals; Azoxymethane; Cholesterol; Colonic Neoplasms; Farnesol; Lanosterol; Lipoproteins, HDL; Male; Precancerous Conditions; Rats; Rats, Inbred F344 | 2002 |
Deguelin suppresses the formation of carcinogen-induced aberrant crypt foci in the colon of CF-1 mice.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; beta-N-Acetylhexosaminidases; Colon; Colonic Neoplasms; Female; Intestinal Mucosa; Mice; Molecular Structure; Piroxicam; Precancerous Conditions; Rotenone | 2003 |
Azoxymethane-induced beta-catenin-accumulated crypts in colonic mucosa of rodents as an intermediate biomarker for colon carcinogenesis.
Topics: Animals; Azoxymethane; beta Catenin; Biomarkers, Tumor; Colon; Colonic Neoplasms; Cytoskeletal Proteins; Intestinal Mucosa; Male; Rats; Risk Assessment; Time Factors; Trans-Activators | 2003 |
Peroxisome proliferator-activated receptor gamma ligands suppress colon carcinogenesis induced by azoxymethane in mice.
Topics: Animals; Antineoplastic Agents; Azoxymethane; Carcinogens; Chromans; Colon; Colonic Neoplasms; Female; Immunohistochemistry; Ligands; Mice; Mice, Inbred BALB C; Pioglitazone; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2003 |
Vitamin E supplementation does not alter azoxymethane-induced colonic aberrant crypt foci formation in young or old mice.
Topics: Aging; Animals; Antioxidants; Azoxymethane; Carcinogens; Choristoma; Colonic Neoplasms; Interferon-gamma; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Vitamin E | 2003 |
Multistage gene expression profiling in a differentially susceptible mouse colon cancer model.
Topics: Adenocarcinoma; Algorithms; Alkylating Agents; Animals; Azoxymethane; Carcinogens; Cluster Analysis; Colonic Neoplasms; Disease Progression; DNA, Complementary; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Male; Mice; Mice, Inbred A; Mice, Inbred AKR; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Species Specificity; Subtraction Technique | 2003 |
Effects of sphingomyelin on aberrant colonic crypt foci development, colon crypt cell proliferation and immune function in an aging rat tumor model.
Topics: Aging; Animals; Azoxymethane; Body Weight; Carcinogens; Cell Division; Colon; Colonic Neoplasms; Hemocyanins; Hypersensitivity, Delayed; Immunity; Immunoglobulin G; Killer Cells, Natural; Male; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Sphingomyelins; Spleen | 2003 |
Consumption of black beans and navy beans (Phaseolus vulgaris) reduced azoxymethane-induced colon cancer in rats.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Azoxymethane; Body Composition; Colon; Colonic Neoplasms; Fatty Acids, Volatile; Gastrointestinal Contents; Ileum; Incidence; Male; Phaseolus; Random Allocation; Rats; Rats, Inbred F344; Starch; Weight Gain | 2002 |
Chemoprevention for colorectal tumorigenesis associated with chronic colitis in mice via apoptosis.
Topics: Animals; Apoptosis; Azoxymethane; Carcinogens; Chemoprevention; Chronic Disease; Colitis; Colon; Colonic Neoplasms; Colorectal Neoplasms; Cyclooxygenase Inhibitors; Intestinal Mucosa; Male; Mice; Mice, Inbred CBA; Sulindac; Water Supply | 2003 |
Effect of age on susceptibility to azoxymethane-induced colonic aberrant crypt foci formation in C57BL/6JNIA mice.
Topics: Age Factors; Animals; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Immunohistochemistry; Isoenzymes; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Prostaglandin-Endoperoxide Synthases; Weight Loss | 2003 |
Food-borne radiolytic compounds (2-alkylcyclobutanones)may promote experimental colon carcinogenesis.
Topics: Analysis of Variance; Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Cyclobutanes; Disease Models, Animal; Food Irradiation; Male; Neoplasms, Experimental; Rats; Rats, Wistar | 2002 |
Identification of mucin-depleted foci in the unsectioned colon of azoxymethane-treated rats: correlation with carcinogenesis.
Topics: Animals; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Male; Mucins; Precancerous Conditions; Probiotics; Rats; Rats, Inbred F344 | 2003 |
Enhancement of colon carcinogenesis by prostaglandin E2 administration.
Topics: Adenocarcinoma; Animals; Apoptosis; Azoxymethane; Bromodeoxyuridine; Carcinogens; Colon; Colonic Neoplasms; Dinoprostone; Disease Progression; DNA Primers; Incidence; Injections, Intraperitoneal; Intestinal Mucosa; Male; Rats; Rats, Inbred F344; Receptors, Prostaglandin E; Reverse Transcriptase Polymerase Chain Reaction | 2003 |
Tomato and garlic can modulate azoxymethane-induced colon carcinogenesis in rats.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Carcinogenicity Tests; Carcinogens; Cell Division; Colon; Colonic Neoplasms; Disease Models, Animal; Garlic; Glutathione Transferase; Injections, Subcutaneous; Lipid Peroxidation; Onions; Phytotherapy; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Solanum lycopersicum | 2003 |
Parp-1 deficiency implicated in colon and liver tumorigenesis induced by azoxymethane.
Topics: Adenocarcinoma; Adenoma; Animals; Azoxymethane; beta Catenin; Carcinogens; Cell Transformation, Neoplastic; Colonic Neoplasms; Cytoskeletal Proteins; Disease Progression; DNA Primers; Female; Homozygote; Liver Neoplasms, Experimental; Mice; Mice, Inbred ICR; Mice, Knockout; Poly(ADP-ribose) Polymerases; Trans-Activators | 2003 |
Ursodeoxycholic acid inhibits Ras mutations, wild-type Ras activation, and cyclooxygenase-2 expression in colon cancer.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Cyclooxygenase 2; Gene Expression Regulation, Neoplastic; Genes, ras; Isoenzymes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transcription, Genetic; Ursodeoxycholic Acid | 2003 |
Characterization of the role of protein kinase C isozymes in colon carcinogenesis using transgenic mouse models.
Topics: Animals; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Disease Models, Animal; Humans; Immunohistochemistry; Isoenzymes; Mice; Mice, Transgenic; Mucous Membrane; Protein Kinase C | 2003 |
Chemopreventive effects of dietary mustard oil on colon tumor development.
Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Corn Oil; Dietary Fats, Unsaturated; Fatty Acids, Omega-3; Male; Mustard Plant; Rats; Rats, Inbred F344 | 2003 |
Tea can protect against aberrant crypt foci formation during azoxymethane induced rat colon carcinogenesis.
Topics: Administration, Oral; Animals; Antioxidants; Azoxymethane; Biological Assay; Carcinogens; Colonic Neoplasms; Flavonoids; Glutathione Peroxidase; Glutathione Transferase; Lipid Peroxidation; Male; Neoplasms, Experimental; Phenols; Polyphenols; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Tea; Time Factors | 2003 |
Whey proteins protect more than red meat against azoxymethane induced ACF in Wistar rats.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Diet; Heme; Meat; Milk Proteins; Precancerous Conditions; Rats; Rats, Wistar; Whey Proteins | 2003 |
Aspirin inhibits endothelial nitric oxide synthase (eNOS) and Flk-1 (vascular endothelial growth factor receptor-2) prior to rat colon tumour development.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Azoxymethane; Caspase 3; Caspases; Colon; Colonic Neoplasms; Immunoenzyme Techniques; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Rats, Inbred WKY; Regional Blood Flow; Up-Regulation; Vascular Endothelial Growth Factor Receptor-2 | 2004 |
The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development.
Topics: Adenocarcinoma; Animals; Apoptosis; Azoxymethane; CDX2 Transcription Factor; Colonic Neoplasms; Genes, Tumor Suppressor; Homeodomain Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutagens; Reverse Transcriptase Polymerase Chain Reaction; Trans-Activators | 2003 |
The effects of parathyroid hormone fragments on bone formation and their lack of effects on the initiation of colon carcinogenesis in rats as indicated by preneoplastic aberrant crypt formation.
Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Osteogenesis; Parathyroid Hormone; Peptide Fragments; Precancerous Conditions; Rats; Rats, Sprague-Dawley | 2003 |
Energy restriction reduces the number of advanced aberrant crypt foci and attenuates the expression of colonic transforming growth factor beta and cyclooxygenase isoforms in Zucker obese (fa/fa) rats.
Topics: Animals; Azoxymethane; Blood Glucose; Body Weight; Caloric Restriction; Carcinogens; Colonic Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Eating; Female; Insulin; Isoenzymes; Lactic Acid; Membrane Proteins; Obesity; Precancerous Conditions; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Zucker; RNA, Messenger; Transforming Growth Factor beta; Triglycerides | 2003 |
Mucin-depleted foci (MDF) in the colon of rats treated with azoxymethane (AOM) are useful biomarkers for colon carcinogenesis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoxymethane; Biomarkers, Tumor; Body Weight; Carcinogens; Cholic Acid; Colon; Colonic Neoplasms; Male; Mucins; Piroxicam; Precancerous Conditions; Rats; Rats, Inbred F344 | 2004 |
A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate.
Topics: Adenocarcinoma; Adenoma; Animals; Anticoagulants; Azoxymethane; beta Catenin; Carcinogens; Colitis; Colonic Neoplasms; Cyclooxygenase 2; Cytoskeletal Proteins; Dextran Sulfate; Disease Models, Animal; Inflammation; Injections, Intraperitoneal; Isoenzymes; Male; Mast Cells; Mice; Mice, Inbred ICR; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin-Endoperoxide Synthases; Trans-Activators; Tumor Suppressor Protein p53 | 2003 |
Intake of beer inhibits azoxymethane-induced colonic carcinogenesis in male Fischer 344 rats.
Topics: Adenocarcinoma; Adenoma; Administration, Oral; Animals; Azoxymethane; Beer; Body Weight; Carcinogens; Colonic Neoplasms; Comet Assay; DNA Damage; Intestinal Mucosa; Male; Rats; Rats, Inbred F344 | 2004 |
Effect of diets fortified with tomatoes or onions with variable quercetin-glycoside content on azoxymethane-induced aberrant crypt foci in the colon of rats.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Carcinogens; Colonic Neoplasms; Dose-Response Relationship, Drug; Food, Fortified; Glycosides; Male; Onions; Quercetin; Random Allocation; Rats; Rats, Inbred F344; Solanum lycopersicum | 2003 |
Effects of green tea and high-fat diet on arachidonic acid metabolism and aberrant crypt foci formation in an azoxymethane-induced colon carcinogenesis mouse model.
Topics: Adipose Tissue; Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Azoxymethane; Body Weight; Colon; Colonic Neoplasms; Cytosol; Dietary Fats; Dinoprostone; Drinking; Eating; Epoxide Hydrolases; Female; Leukotriene B4; Mice; Organ Size; Phospholipases A; Phospholipases A2; Tea | 2003 |
Effects of high amylose maize starch and Clostridium butyricum on metabolism in colonic microbiota and formation of azoxymethane-induced aberrant crypt foci in the rat colon.
Topics: Amylose; Animals; Azoxymethane; Body Weight; Butyrates; Carcinogens; Clostridium; Colon; Colonic Neoplasms; Dietary Fiber; Fatty Acids; Fermentation; Glucuronidase; Lactates; Male; Organ Size; Precancerous Conditions; Probiotics; Rats; Rats, Inbred F344; Spores, Bacterial; Starch; Succinates; Zea mays | 2003 |
Dietary soy isoflavones and estrone protect ovariectomized ERalphaKO and wild-type mice from carcinogen-induced colon cancer.
Topics: Animals; Azoxymethane; Carcinogens; Caseins; Colonic Neoplasms; Diet; Estrogen Receptor alpha; Estrone; Genistein; Glycine max; Isoflavones; Mice; Mice, Knockout; Ovariectomy; Receptors, Estrogen; Soybean Proteins | 2004 |
Analysis of beta-catenin, Ki-ras, and microsatellite stability in azoxymethane-induced colon tumors of BDIX/Orl Ico rats.
Topics: Adenocarcinoma; Animals; Azoxymethane; beta Catenin; Colonic Neoplasms; Cytoskeletal Proteins; DNA Mutational Analysis; DNA, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Genes, ras; Immunoenzyme Techniques; Male; Microsatellite Repeats; Polymerase Chain Reaction; Proto-Oncogene Mas; Rats; Rats, Inbred Strains; Trans-Activators | 2003 |
Enhancement of development of azoxymethane-induced colonic premalignant lesions in C57BL/KsJ-db/db mice.
Topics: Animals; Azoxymethane; Blood Glucose; Body Weight; Carcinogens; Colonic Neoplasms; Diabetes Mellitus, Experimental; Heterozygote; Homozygote; Hyperinsulinism; Immunoblotting; Insulin; Leptin; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Precancerous Conditions; Receptor, IGF Type 1; Receptors, Cell Surface; Receptors, Leptin | 2004 |
Interaction of conjugated linoleic acid, sphingomyelin, and butyrate on formation of colonic aberrant crypt foci and immune functions in rats.
Topics: Animals; Azoxymethane; Butyrates; Carcinogens; Colon; Colonic Neoplasms; Drug Interactions; Immune System; Intestinal Mucosa; Killer Cells, Natural; Linoleic Acids, Conjugated; Lipids; Male; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Sphingomyelins | 2004 |
Leptin reduces the development of the initial precancerous lesions induced by azoxymethane in the rat colonic mucosa.
Topics: Animals; Azoxymethane; Carcinogens; Cell Division; Colonic Neoplasms; Infusion Pumps; Injections; Intestinal Mucosa; Leptin; Male; Precancerous Conditions; Rats; Rats, Inbred F344; Recombinant Proteins | 2004 |
Carcinogen-induced colon tumors in mice are chromosomally stable and are characterized by low-level microsatellite instability.
Topics: Aneuploidy; Animals; Azoxymethane; beta Catenin; Colonic Neoplasms; Cytoskeletal Proteins; Genomic Instability; Male; Mice; Microsatellite Repeats; Trans-Activators | 2004 |
Intestinal expression of mutant and wild-type progastrin significantly increases colon carcinogenesis in response to azoxymethane in transgenic mice.
Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Female; Gastrins; Humans; Male; Mice; Mice, Transgenic; Polymerase Chain Reaction; Precancerous Conditions; Protein Precursors; Radioimmunoassay | 2004 |
Protein kinase Ciota is required for Ras transformation and colon carcinogenesis in vivo.
Topics: Animals; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colonic Neoplasms; Enzyme Activation; Epithelial Cells; Humans; Intestinal Mucosa; Isoenzymes; Mice; Mice, Inbred C57BL; Mice, Transgenic; Protein Kinase C; rac1 GTP-Binding Protein; ras Proteins; Rats; Signal Transduction | 2004 |
The modifying effect of Peucedanum japonicum, a herb in the Ryukyu Islands, on azoxymethane-induced colon preneoplastic lesions in male F344 rats.
Topics: Animals; Antioxidants; Apiaceae; Azoxymethane; beta Catenin; Colonic Neoplasms; Cytoskeletal Proteins; Lipid Peroxidation; Male; Plant Extracts; Precancerous Conditions; Rats; Rats, Inbred F344; Trans-Activators | 2004 |
Peroxisome proliferator-activated receptor-delta attenuates colon carcinogenesis.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Colonic Polyps; Disease Models, Animal; Mice; Mice, Knockout; Mice, Mutant Strains; Phenotype; Receptors, Cytoplasmic and Nuclear; Transcription Factors | 2004 |
Tumor formation is correlated with expression of beta-catenin-accumulated crypts in azoxymethane-induced colon carcinogenesis in mice.
Topics: Adenocarcinoma; Adenoma; Animals; Azoxymethane; beta Catenin; Biomarkers, Tumor; Carcinogens; Colonic Neoplasms; Cytoskeletal Proteins; Genetic Predisposition to Disease; Intestinal Mucosa; Mice; Mice, Inbred AKR; Mucins; Neoplasm Proteins; Specific Pathogen-Free Organisms; Trans-Activators | 2004 |
Modulatory influence of garlic and tomato on cyclooxygenase-2 activity, cell proliferation and apoptosis during azoxymethane induced colon carcinogenesis in rat.
Topics: Animals; Apoptosis; Azoxymethane; Cell Division; Colonic Neoplasms; Cyclooxygenase 2; Garlic; Isoenzymes; Male; Precancerous Conditions; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Solanum lycopersicum | 2004 |
[Pharmacological effects of Daphne genkwa and Chinese medical prescription, "Jyu-So-To"].
Topics: Animals; Anti-Allergic Agents; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Azoxymethane; Colonic Neoplasms; Daphne; Dinitrofluorobenzene; Drugs, Chinese Herbal; Ear Diseases; Edema; Female; Hypersensitivity; Male; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Phytotherapy; Plant Extracts; Tetradecanoylphorbol Acetate | 2004 |
Dietary seed oil rich in conjugated linolenic acid from bitter melon inhibits azoxymethane-induced rat colon carcinogenesis through elevation of colonic PPARgamma expression and alteration of lipid composition.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Azoxymethane; Colonic Neoplasms; Dietary Fats; Incidence; Intestinal Mucosa; Linoleic Acids, Conjugated; Male; Momordica charantia; Phytotherapy; Plant Oils; Rats; Rats, Inbred F344; Receptors, Cytoplasmic and Nuclear; Transcription Factors | 2004 |
Preventive effects of extract of leaves of ginkgo (Ginkgo biloba) and its component bilobalide on azoxymethane-induced colonic aberrant crypt foci in rats.
Topics: Administration, Oral; Animals; Azoxymethane; Carcinogens; Chemoprevention; Colonic Neoplasms; Cyclopentanes; Cytochrome P-450 Enzyme System; Diet; Diterpenes; Furans; Ginkgo biloba; Ginkgolides; Glutathione Transferase; Immunohistochemistry; Male; Phytotherapy; Plant Extracts; Plant Leaves; Precancerous Conditions; Proliferating Cell Nuclear Antigen; Rats; Rats, Inbred F344 | 2004 |
Lactoferrin enhances Fas expression and apoptosis in the colon mucosa of azoxymethane-treated rats.
Topics: Animals; Apoptosis; Azoxymethane; Carcinogens; Caspases; Cattle; Cell Transformation, Neoplastic; Chemoprevention; Colon; Colonic Neoplasms; Enzyme Activation; fas Receptor; Immunoenzyme Techniques; Lactoferrin; Male; Proteins; Rats; Rats, Inbred F344; Receptors, Tumor Necrosis Factor | 2004 |
Modulation by celecoxib and difluoromethylornithine of the methylation of DNA and the estrogen receptor-alpha gene in rat colon tumors.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Azoxymethane; Biomarkers, Tumor; Carcinogens; Celecoxib; Colon; Colonic Neoplasms; CpG Islands; Diet; DNA Methylation; Eflornithine; Estrogen Receptor alpha; Male; Pyrazoles; Rats; Rats, Inbred F344; Receptors, Estrogen; RNA, Messenger; Sulfonamides | 2004 |
Effects of adlay on azoxymethane-induced colon carcinogenesis in rats.
Topics: Animals; Azoxymethane; Body Weight; Carcinogens; Coix; Colon; Colonic Neoplasms; Cyclooxygenase 2; Diet; Eating; Isoenzymes; Male; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred F344; Taiwan | 2004 |
Transforming growth factor beta receptor type II inactivation promotes the establishment and progression of colon cancer.
Topics: Animals; Apoptosis; Azoxymethane; Carcinogens; Carrier Proteins; Cell Differentiation; Cell Division; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Cyclooxygenase 2; Disease Models, Animal; Disease Progression; Fatty Acid-Binding Proteins; Female; Gene Silencing; Genetic Predisposition to Disease; Isoenzymes; Male; Mice; Mutation; Prostaglandin-Endoperoxide Synthases; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta | 2004 |
Diosgenin, a steroid saponin of Trigonella foenum graecum (Fenugreek), inhibits azoxymethane-induced aberrant crypt foci formation in F344 rats and induces apoptosis in HT-29 human colon cancer cells.
Topics: Animals; Apoptosis; Azoxymethane; Cell Division; Colonic Neoplasms; Diosgenin; Disease Models, Animal; History, Early Modern 1451-1600; HT29 Cells; Humans; Intestinal Mucosa; Male; Plant Extracts; Precancerous Conditions; Random Allocation; Rats; Rats, Inbred F344; Reference Values; Saponins; Sensitivity and Specificity; Trigonella; Tumor Cells, Cultured | 2004 |
Lactoferrin modifies apoptosis-related gene expression in the colon of the azoxymethane-treated rat.
Topics: Administration, Oral; Animals; Apoptosis; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Chemoprevention; Colonic Neoplasms; Cyclin D1; Disease Models, Animal; Fas Ligand Protein; Gene Expression Regulation; Lactoferrin; Male; Membrane Glycoproteins; Rats; Rats, Inbred F344; Up-Regulation | 2004 |
Chemopreventive n-3 polyunsaturated fatty acids reprogram genetic signatures during colon cancer initiation and progression in the rat.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Carcinogens; Cell Differentiation; Colonic Neoplasms; Disease Progression; DNA Adducts; Down-Regulation; Eating; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Fatty Acids, Unsaturated; Fish Oils; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Male; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Triglycerides; Up-Regulation; Weight Gain | 2004 |
Tumor suppressor functions for the Cdk inhibitor p21 in the mouse colon.
Topics: Animals; Apoptosis; Azoxymethane; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Female; In Situ Nick-End Labeling; Mice; Precancerous Conditions | 2004 |
Chemopreventive effect of dietary d-alpha-tocopheryl succinate supplementation on precancer colon aberrant crypt formation and vitamin E analogue levels in young and old rats.
Topics: Aging; Animals; Antioxidants; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Dietary Supplements; Female; Rats; Rats, Sprague-Dawley; Tissue Distribution; Tocopherols; Vitamin E | 2004 |
Beef meat and blood sausage promote the formation of azoxymethane-induced mucin-depleted foci and aberrant crypt foci in rat colons.
Topics: Animals; Azoxymethane; Carcinogens; Cattle; Chickens; Colonic Neoplasms; Diet; Female; Heme; Lipid Peroxidation; Meat; Mucins; Rats; Rats, Inbred F344 | 2004 |
Sequential observations on the occurrence of preneoplastic and neoplastic lesions in mouse colon treated with azoxymethane and dextran sodium sulfate.
Topics: Adenocarcinoma; Animals; Azoxymethane; Carcinogens; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Immunoenzyme Techniques; Incidence; Injections, Intraperitoneal; Intestinal Mucosa; Male; Mice; Mice, Inbred ICR; Precancerous Conditions; Tyrosine | 2004 |
Fecal water genotoxicity is predictive of tumor-preventive activities by inulin-like oligofructoses, probiotics (Lactobacillus rhamnosus and Bifidobacterium lactis), and their synbiotic combination.
Topics: Animals; Azoxymethane; Bifidobacterium; Biomarkers; Carcinogens; Colonic Neoplasms; Comet Assay; Feces; Gastrointestinal Contents; HT29 Cells; Humans; Lactobacillus; Male; Mutagenicity Tests; Oligosaccharides; Probiotics; Random Allocation; Rats; Rats, Inbred F344 | 2004 |
Dietary iron promotes azoxymethane-induced colon tumors in mice.
Topics: Animals; Apoptosis; Azoxymethane; Carcinogens; Cell Division; Colonic Neoplasms; Disease Models, Animal; DNA Damage; Dose-Response Relationship, Drug; In Situ Nick-End Labeling; Iron, Dietary; Mice; Oxidative Stress; Precancerous Conditions; Random Allocation; Time Factors | 2004 |
Extract of Kurosu, a vinegar from unpolished rice, inhibits azoxymethane-induced colon carcinogenesis in male F344 rats.
Topics: Acetic Acid; Animals; Anticarcinogenic Agents; Azoxymethane; Carcinogens; Colonic Neoplasms; Dose-Response Relationship, Drug; Drinking; Male; Oryza; Plant Extracts; Random Allocation; Rats; Rats, Inbred F344 | 2004 |
Low doses of beta-carotene and lutein inhibit AOM-induced rat colonic ACF formation but high doses augment ACF incidence.
Topics: Animals; Antioxidants; Azoxymethane; beta Carotene; Carcinogens; Chemoprevention; Colonic Neoplasms; Diet; Dose-Response Relationship, Drug; Lutein; Male; Precancerous Conditions; Rats; Rats, Inbred F344 | 2005 |
Secondary effects induced by the colon carcinogen azoxymethane in BDIX rats.
Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Female; Intestinal Neoplasms; Kidney; Kidney Neoplasms; Liver; Liver Neoplasms; Male; Rats; Receptors, Estrogen; Receptors, Progesterone; Sex Characteristics | 2004 |
Dietary corn oil promotes colon cancer by inhibiting mitochondria-dependent apoptosis in azoxymethane-treated rats.
Topics: Animals; Apoptosis; Azoxymethane; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; bcl-X Protein; Blotting, Western; Carcinogens; Cell Division; Colonic Neoplasms; Corn Oil; Gene Expression Regulation, Neoplastic; Genes, p53; Male; Membrane Proteins; Mitochondria; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction | 2004 |
Prostaglandin E receptor subtype EP(1) deficiency inhibits colon cancer development.
Topics: Adenocarcinoma; Adenoma; Animals; Apoptosis; Azoxymethane; Cell Proliferation; Colonic Neoplasms; Mice; Mice, Knockout; Protein Kinase C; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype | 2005 |
Leptin reduces the development of the initial precancerous lesions induced by azoxymethane in the rat colonic mucosa.
Topics: Animals; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colonic Neoplasms; Intestinal Mucosa; Leptin; Obesity; Precancerous Conditions; Rats; Rats, Zucker | 2004 |
Immunohistochemical characterisation of the local immune response in azoxymethane-induced colon tumours in the BDIX inbred rat strain.
Topics: Animals; Azoxymethane; CD8-Positive T-Lymphocytes; Colonic Neoplasms; Disease Models, Animal; Immunohistochemistry; Rats | 2004 |
Intestinal immunity of rats with colon cancer is modulated by oligofructose-enriched inulin combined with Lactobacillus rhamnosus and Bifidobacterium lactis.
Topics: Animals; Azoxymethane; Bifidobacterium; Carcinogens; Cell Division; Colonic Neoplasms; Diet; Disease Models, Animal; Interferons; Interleukin-10; Inulin; Killer Cells, Natural; Lactobacillus; Lymph Nodes; Lymphocyte Subsets; Male; Oligosaccharides; Peyer's Patches; Probiotics; Rats; Rats, Inbred F344; Spleen | 2004 |
The nonsteroidal anti-inflammatory drug, nabumetone, differentially inhibits beta-catenin signaling in the MIN mouse and azoxymethane-treated rat models of colon carcinogenesis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoxymethane; beta Catenin; Blotting, Western; Butanones; Cadherins; Carcinogens; Colonic Neoplasms; Cyclin D1; Cytoskeletal Proteins; Disease Models, Animal; Glycogen Synthase Kinase 3; Immunohistochemistry; Male; Mice; Nabumetone; Rats; Signal Transduction; Trans-Activators | 2005 |
Flat dysplastic aberrant crypt foci are related to tumorigenesis in the colon of azoxymethane-treated rat.
Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Coloring Agents; Hyperplasia; Intestinal Mucosa; Male; Rats; Rats, Inbred F344 | 2005 |
Absence of acute apoptotic response to genotoxic carcinogens in p53-deficient mice is associated with increased susceptibility to azoxymethane-induced colon tumours.
Topics: Animals; Apoptosis; Azoxymethane; Colonic Neoplasms; DNA Primers; Genotype; Mice; Mice, Inbred C57BL; Mice, Knockout; Polymerase Chain Reaction; Tumor Suppressor Protein p53 | 2005 |
Folate transport gene inactivation in mice increases sensitivity to colon carcinogenesis.
Topics: Animals; Azoxymethane; Carcinogens; Carrier Proteins; Cell Cycle; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Folate Receptors, GPI-Anchored; Gene Expression Profiling; Gene Silencing; Genetic Predisposition to Disease; Kidney; Male; Membrane Transport Modulators; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligonucleotide Array Sequence Analysis; Precancerous Conditions; Receptors, Cell Surface; Reduced Folate Carrier Protein; Reverse Transcriptase Polymerase Chain Reaction; S-Adenosylhomocysteine; S-Adenosylmethionine | 2005 |
Beta-Catenin mutations in a mouse model of inflammation-related colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sodium sulfate.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Azoxymethane; beta Catenin; Colitis; Colonic Neoplasms; Cyclooxygenase 2; Cytoskeletal Proteins; Dextran Sulfate; Disease Models, Animal; Immunohistochemistry; Inflammation; Male; Mice; Mice, Inbred ICR; Mutation; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin-Endoperoxide Synthases; Trans-Activators | 2005 |
Induction by lysophosphatidic acid of peritoneal and pleural metastases of intestinal cancers induced by azoxymethane in Wistar rats.
Topics: Adenocarcinoma; Animals; Azoxymethane; Body Weight; Carcinogens; Colonic Neoplasms; Intestinal Neoplasms; Lysophospholipids; Male; Peritoneal Neoplasms; Pleural Neoplasms; Proliferating Cell Nuclear Antigen; Rats; Rats, Wistar; rhoA GTP-Binding Protein | 2005 |
Dose-dependent promoting effect of dextran sodium sulfate on mouse colon carcinogenesis initiated with azoxymethane.
Topics: Animals; Azoxymethane; Carcinogens; Cocarcinogenesis; Colitis; Colonic Diseases; Colonic Neoplasms; Dextran Sulfate; Dose-Response Relationship, Drug; Intestinal Mucosa; Male; Mice; Mice, Inbred ICR; Tyrosine; Ulcer | 2005 |
Inhibitory effects of feeding with carrots or (-)-falcarinol on development of azoxymethane-induced preneoplastic lesions in the rat colon.
Topics: Alkynes; Animals; Azoxymethane; Colonic Neoplasms; Daucus carota; Diet; Diynes; Fatty Alcohols; Male; Plant Extracts; Precancerous Conditions; Rats | 2005 |
Chemopreventive effects of dietary flaxseed oil on colon tumor development.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Corn Oil; Dietary Fats, Unsaturated; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Linseed Oil; Male; Random Allocation; Rats; Rats, Inbred F344 | 2005 |
Citrus nobiletin inhibits azoxymethane-induced large bowel carcinogenesis in rats.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Citrus; Colonic Neoplasms; Dinoprostone; Flavones; Intestinal Mucosa; Male; Phytotherapy; Polyamines; Proliferating Cell Nuclear Antigen; Rats; Rats, Inbred F344 | 2004 |
Modifying effects of Terminalia catappa on azoxymethane-induced colon carcinogenesis in male F344 rats.
Topics: Administration, Oral; Animals; Azoxymethane; Biomarkers, Tumor; Carcinogens; Cell Transformation, Neoplastic; Chemoprevention; Colonic Diseases; Colonic Neoplasms; Male; Phytotherapy; Plant Extracts; Proliferating Cell Nuclear Antigen; Random Allocation; Rats; Rats, Inbred F344; Terminalia | 2005 |
Cytoplasmic phospholipase A2 deletion enhances colon tumorigenesis.
Topics: Animals; Apoptosis; Azoxymethane; Colonic Neoplasms; Crosses, Genetic; Cyclooxygenase 2; Cytoplasm; Dinoprostone; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Phospholipases A; Phospholipases A2; Prostaglandin-Endoperoxide Synthases | 2005 |
Chemoprevention: mouse colon and lung tumor bioassay and modulation of DNA methylation as a biomarker.
Topics: Animals; Azoxymethane; Biological Assay; Biomarkers; Budesonide; Carcinogens; Chemoprevention; Colonic Neoplasms; Dexamethasone; DNA Methylation; Dose-Response Relationship, Drug; Glucocorticoids; Insulin-Like Growth Factor II; Lung Neoplasms; Mice; Mice, Inbred Strains; Piroxicam; Urethane | 2005 |
Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin).
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Azoxymethane; Carcinogens; Colonic Neoplasms; Dietary Supplements; Disease Models, Animal; Intestinal Mucosa; Male; Panax; Plant Extracts; Quercetin; Rats; Rats, Inbred F344; Rutin; Silymarin | 2005 |
Increased microvascular blood content is an early event in colon carcinogenesis.
Topics: Adenoma; Animals; Azoxymethane; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Disease Models, Animal; Disease Progression; Hemoglobins; Humans; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Microcirculation; Optics and Photonics; Pilot Projects; Precancerous Conditions; Rats; Rats, Inbred F344; Scattering, Radiation | 2005 |
In vivo measurement of DNA synthesis rates of colon epithelial cells in carcinogenesis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Aspirin; Azoxymethane; Body Water; Bromodeoxyuridine; Cell Cycle; Cell Proliferation; Cholic Acid; Colon; Colonic Neoplasms; Deuterium; DNA; Epithelial Cells; Gas Chromatography-Mass Spectrometry; Kinetics; Male; Rats; Rats, Sprague-Dawley | 2005 |
Sulindac corrects defective apoptosis and suppresses azoxymethane-induced colonic oncogenesis in p53 knockout mice.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Apoptosis; Azoxymethane; Colonic Neoplasms; Mice; Mice, Inbred C57BL; Mice, Knockout; Sulindac; Tumor Suppressor Protein p53 | 2005 |
Abdominal obesity, insulin resistance, and colon carcinogenesis are increased in mutant mice lacking gastrin gene expression.
Topics: Animals; Azoxymethane; Body Weight; Carcinogens; Colonic Neoplasms; Gastrins; Gene Expression; Ghrelin; Glucose; Hyperinsulinism; Insulin; Insulin Resistance; Leptin; Magnetic Resonance Imaging; Male; Mice; Mice, Knockout; Obesity; Peptide Hormones; Precancerous Conditions; Radioimmunoassay; Thinness | 2005 |
Tissue-specific attenuation of endogenous DNA I-compounds in rats by carcinogen azoxymethane: possible role of dietary fish oil in colon cancer prevention.
Topics: Analysis of Variance; Animals; Azoxymethane; Biomarkers; Carcinogens; Colonic Neoplasms; Corn Oil; DNA Adducts; DNA Damage; Duodenal Neoplasms; Fish Oils; Male; Models, Animal; Nucleotides; Radioligand Assay; Rats; Rats, Sprague-Dawley; Single-Strand Specific DNA and RNA Endonucleases | 2005 |
Polyethylene glycol reduces inflammation and aberrant crypt foci in carcinogen-initiated rats.
Topics: Administration, Oral; Animals; Azoxymethane; Caco-2 Cells; Carcinogens; Colon; Colonic Neoplasms; Humans; Inflammation; Male; Permeability; Polyethylene Glycols; Precancerous Conditions; Rats; Rats, Inbred F344; Solvents | 2005 |
Suppression of azoxymethane-induced colon cancer development in rats by a prostaglandin E receptor EP1-selective antagonist.
Topics: Animals; Apoptosis; Azoxymethane; Bridged Bicyclo Compounds; Caproates; Colonic Neoplasms; Male; Rats; Rats, Inbred F344; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype | 2005 |
A high-fat diet enhances the inhibitory effect of dietary vitamin B6 on colon cell proliferation in mice.
Topics: Animals; Apoptosis; Azoxymethane; Body Weight; Bromodeoxyuridine; Cell Proliferation; Colon; Colonic Neoplasms; Dietary Fats; Dietary Supplements; Dose-Response Relationship, Drug; Eating; In Situ Nick-End Labeling; Male; Mice; Mice, Inbred ICR; Pyridoxine | 2005 |
In vivo imaging of colitis and colon cancer development in mice using high resolution chromoendoscopy.
Topics: Animals; Azoxymethane; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Colonoscopes; Colonoscopy; Dextran Sulfate; Disease Models, Animal; Disease Progression; Intestinal Mucosa; Mice; Mice, Inbred Strains; Severity of Illness Index | 2005 |
Dietary supplement of isohumulones inhibits the formation of aberrant crypt foci with a concomitant decrease in prostaglandin E2 level in rat colon.
Topics: Animals; Azoxymethane; Beer; Carcinogens; Cell Line; Colon; Colonic Neoplasms; Cyclopentanes; Dietary Supplements; Dinoprostone; Interferon-gamma; Intestinal Mucosa; Ionophores; Lipopolysaccharides; Macrophages; Male; Mice; Precancerous Conditions; Rats; Rats, Inbred F344 | 2005 |
Senna and the formation of aberrant crypt foci and tumors in rats treated with azoxymethane.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Azoxymethane; Cathartics; Colonic Neoplasms; Male; Phytotherapy; Precancerous Conditions; Rats; Rats, Wistar; Senna Extract; Senna Plant | 2005 |
Effect of concomitant polyethylene glycol and celecoxib on colonic aberrant crypt foci and tumors in F344 rats.
Topics: Animals; Azoxymethane; Bromodeoxyuridine; Celecoxib; Colon; Colonic Neoplasms; Cyclooxygenase Inhibitors; Cytoprotection; Drug Synergism; Female; Immunohistochemistry; Male; Polyethylene Glycols; Pyrazoles; Rats; Rats, Inbred F344; Staining and Labeling; Sulfonamides | 2005 |
Strain differences in the susceptibility to azoxymethane and dextran sodium sulfate-induced colon carcinogenesis in mice.
Topics: Adenocarcinoma; Adenoma; Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Dextran Sulfate; Disease Susceptibility; Injections, Intraperitoneal; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA | 2006 |
Identification of flat dysplastic aberrant crypt foci in the colon of azoxymethane-treated A/J mice.
Topics: Animals; Azoxymethane; beta Catenin; Carcinogens; Cell Nucleus; Colonic Neoplasms; Cyclin D1; Female; Hyperplasia; Male; Mice; Mice, Inbred A; Precancerous Conditions | 2006 |
Effects of indole-3-carbinol and phenethyl isothiocyanate on colon carcinogenesis induced by azoxymethane in rats.
Topics: Administration, Oral; Animal Feed; Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Carcinogens; Cell Proliferation; Colonic Neoplasms; Cytochrome P-450 CYP2E1; Indoles; Isothiocyanates; Male; Rats; Rats, Wistar; Risk Factors | 2006 |
Prevention of colon cancer by low doses of celecoxib, a cyclooxygenase inhibitor, administered in diet rich in omega-3 polyunsaturated fatty acids.
Topics: Animals; Azoxymethane; Carcinogens; Celecoxib; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diet; Dose-Response Relationship, Drug; Fatty Acids, Omega-3; Male; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Inbred F344; Sulfonamides | 2005 |
Dietary artepillin C suppresses the formation of aberrant crypt foci induced by azoxymethane in mouse colon.
Topics: Animals; Antineoplastic Agents; Antioxidants; Azoxymethane; Carcinogens; Colonic Neoplasms; Diet; Dose-Response Relationship, Drug; Glutathione Transferase; Intestinal Mucosa; Liver; Male; Mice; NAD(P)H Dehydrogenase (Quinone); Phenylpropionates; Precancerous Conditions; Propolis; Response Elements; Up-Regulation | 2006 |
Decrease in size of azoxymethane induced colon carcinoma in F344 rats by 180-day fermented miso.
Topics: Animals; Azoxymethane; beta Catenin; Carcinogens; Cell Proliferation; Colonic Neoplasms; Dietary Supplements; Fermentation; Immunohistochemistry; Injections, Subcutaneous; Intestinal Mucosa; Male; Proliferating Cell Nuclear Antigen; Rats; Rats, Inbred F344; Soy Foods; Time Factors | 2005 |
Red wine polyphenols influence carcinogenesis, intestinal microflora, oxidative damage and gene expression profiles of colonic mucosa in F344 rats.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Comet Assay; Diet; DNA Damage; Flavonoids; Gene Expression Profiling; Gene Expression Regulation; Humans; Intestinal Mucosa; Male; Oligonucleotide Array Sequence Analysis; Oxidation-Reduction; Phenols; Polyphenols; Rats; Rats, Inbred F344; Wine | 2005 |
Mitogenic effects of both amidated and glycine-extended gastrin-releasing peptide in defunctioned and azoxymethane-treated rat colon in vivo.
Topics: Animals; Azoxymethane; Cell Proliferation; Colon; Colonic Neoplasms; Gastrin-Releasing Peptide; Glycine; Male; Mitosis; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Rectum; Species Specificity; Time Factors | 2006 |
Sphingosine kinase 1 is up-regulated in colon carcinogenesis.
Topics: Animals; Azoxymethane; Cell Line, Tumor; Colon; Colonic Neoplasms; Cyclooxygenase 2; Dinoprostone; Epithelial Cells; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Intestinal Mucosa; Lysophospholipids; Male; Mice; Mice, Inbred BALB C; Phosphotransferases (Alcohol Group Acceptor); Rats; Rats, Inbred F344; Sphingosine; Up-Regulation | 2006 |
Effect of dried plums on colon cancer risk factors in rats.
Topics: Animals; Azoxymethane; Bile Acids and Salts; Cecum; Colonic Neoplasms; Dose-Response Relationship, Drug; Feces; Glucuronidase; Male; Nitroreductases; Oxidoreductases; Precancerous Conditions; Prunus; Random Allocation; Rats; Rats, Wistar; Risk Factors | 2005 |
T cell deficiency leads to liver carcinogenesis in azoxymethane-treated rats.
Topics: Animals; Apoptosis; Azoxymethane; Blotting, Western; Carcinogenicity Tests; Cell Proliferation; Colonic Neoplasms; DNA; Gene Expression Regulation, Neoplastic; Genes, p53; Liver Neoplasms; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; T-Lymphocytes; Time Factors | 2006 |
Risk stratification of colon carcinogenesis through enhanced backscattering spectroscopy analysis of the uninvolved colonic mucosa.
Topics: Animals; Azoxymethane; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Disease Models, Animal; Disease Progression; Equipment Design; Female; Humans; Light; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Middle Aged; Pilot Projects; Predictive Value of Tests; Radiography; Rats; Rats, Inbred F344; Risk Factors; Scattering, Radiation; Sensitivity and Specificity; Spectrum Analysis | 2006 |
Modifying effect of dietary sesaminol glucosides on the formation of azoxymethane-induced premalignant lesions of rat colon.
Topics: Animals; Azoxymethane; Colon; Colonic Neoplasms; Dietary Supplements; Dioxoles; Fatty Acid-Binding Proteins; Furans; Gene Expression; Glucosides; Intestinal Mucosa; Male; Molecular Structure; Precancerous Conditions; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sesamum; Triglycerides | 2007 |
Noninvasive monitoring of colonic carcinogenesis: feasibility of [(18)F]FDG-PET in the azoxymethane model.
Topics: Adenocarcinoma; Animals; Azoxymethane; Colonic Neoplasms; Disease Models, Animal; Feasibility Studies; Fluorodeoxyglucose F18; Male; Metabolic Clearance Rate; Organ Specificity; Radionuclide Imaging; Radiopharmaceuticals; Rats; Rats, Inbred F344; Reproducibility of Results; Sensitivity and Specificity; Tissue Distribution | 2006 |
Preventive effects of chrysin on the development of azoxymethane-induced colonic aberrant crypt foci in rats.
Topics: Administration, Oral; Animals; Apoptosis; Azoxymethane; Carcinogens; Chemoprevention; Colonic Neoplasms; Diet; Flavonoids; Injections, Subcutaneous; Male; Mitosis; Precancerous Conditions; Rats; Rats, Inbred F344 | 2006 |
Ligand activation of peroxisome proliferator-activated receptor beta inhibits colon carcinogenesis.
Topics: Animals; Azoxymethane; Cathepsin E; Colonic Neoplasms; Fatty Acid-Binding Proteins; Ligands; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Perilipin-2; PPAR-beta; RNA, Messenger; Thiazoles | 2006 |
Prevention of azoxymethane-induced colon cancer by combination of low doses of atorvastatin, aspirin, and celecoxib in F 344 rats.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Aspirin; Atorvastatin; Azoxymethane; Carcinogens; Celecoxib; Cell Growth Processes; Colonic Neoplasms; Dose-Response Relationship, Drug; Heptanoic Acids; Male; Pyrazoles; Pyrroles; Rats; Rats, Inbred F344; Sulfonamides | 2006 |
Deletion of the carcinoembryonic antigen-related cell adhesion molecule 1 (Ceacam1) gene contributes to colon tumor progression in a murine model of carcinogenesis.
Topics: Animals; Azoxymethane; Blotting, Western; Carcinoembryonic Antigen; Carcinogens; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Disease Models, Animal; Disease Progression; Gene Targeting; Genotype; Mice; Mice, Inbred C57BL; Mice, Knockout | 2006 |
Inhibition of intestinal carcinogenesis by a new flavone derivative, chafuroside, in oolong tea.
Topics: Animals; Antineoplastic Agents; Azoxymethane; Camellia; Colonic Neoplasms; Diet; Disease Models, Animal; Female; Flavones; Heterocyclic Compounds, 4 or More Rings; Intestinal Mucosa; Intestinal Polyps; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phytotherapy; Rats; Rats, Inbred F344; Tea | 2006 |
Increased colon tumor susceptibility in azoxymethane treated CEABAC transgenic mice.
Topics: Animals; Antigens, CD; Azoxymethane; beta Catenin; Carcinoembryonic Antigen; Carcinogens; Cell Adhesion Molecules; Colonic Neoplasms; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Glycosylphosphatidylinositols; GPI-Linked Proteins; Humans; Mice; Mice, Transgenic; Mutation | 2006 |
Polyethylene glycol, unique among laxatives, suppresses aberrant crypt foci, by elimination of cells.
Topics: Animals; Azoxymethane; Carcinogens; Cathartics; Colonic Neoplasms; Feces; Polyethylene Glycols; Precancerous Conditions; Random Allocation; Rats; Rats, Inbred F344; Toxicity Tests, Acute | 2006 |
Beta-escin inhibits colonic aberrant crypt foci formation in rats and regulates the cell cycle growth by inducing p21(waf1/cip1) in colon cancer cells.
Topics: Aesculus; Animals; Apoptosis; Azoxymethane; Carcinogens; Cell Cycle; Cell Division; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Diet; Dose-Response Relationship, Drug; Escin; HCT116 Cells; HT29 Cells; Humans; Intestinal Mucosa; Male; Plant Extracts; Rats; Rats, Inbred F344 | 2006 |
Nitric oxide-releasing aspirin and indomethacin are potent inhibitors against colon cancer in azoxymethane-treated rats: effects on molecular targets.
Topics: Acetates; Animals; Antineoplastic Agents; Aspirin; Azoxymethane; beta Catenin; Carcinogens; Colonic Neoplasms; Cyclooxygenase 2; Diet; Dinoprostone; Humans; Indoles; Male; Nitric Oxide Synthase Type II; Rats; Rats, Inbred F344 | 2006 |
Red palm oil suppresses the formation of azoxymethane (AOM) induced aberrant crypt foci (ACF) in Fisher 344 male rats.
Topics: Animals; Azoxymethane; Carotenoids; Colonic Neoplasms; Eating; Glutathione Transferase; Liver; Male; Palm Oil; Plant Oils; Precancerous Conditions; Rats; Rats, Inbred F344; Soybean Oil; Vitamin E; Weight Gain | 2006 |
Chemopreventive potential of diallylsulfide, lycopene and theaflavin during chemically induced colon carcinogenesis in rat colon through modulation of cyclooxygenase-2 and inducible nitric oxide synthase pathways.
Topics: Allyl Compounds; Animals; Anticarcinogenic Agents; Azoxymethane; Biflavonoids; Carotenoids; Catechin; Colon; Colonic Neoplasms; Cyclooxygenase 2; Lycopene; Male; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Signal Transduction; Sulfides | 2006 |
15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis.
Topics: Animals; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Cyclin D1; Humans; Hydroxyprostaglandin Dehydrogenases; Ki-67 Antigen; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Prostaglandins G | 2006 |
Methionine restriction inhibits colon carcinogenesis.
Topics: Animals; Azoxymethane; Biological Assay; Carcinogens; Cell Division; Colon; Colonic Neoplasms; Intestinal Mucosa; Male; Methionine; Precancerous Conditions; Random Allocation; Rats; Rats, Inbred F344 | 2006 |
Selenised casein protects against AOM-induced colon tumors in Sprague Dawley rats.
Topics: Animals; Azoxymethane; Biological Availability; Body Weight; Carcinogens; Caseins; Colon; Colonic Neoplasms; Dose-Response Relationship, Drug; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Selenium; Yeasts | 2006 |
Chemopreventive effects of dietary flaxseed on colon tumor development.
Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Corn Oil; Cyclooxygenase 1; Cyclooxygenase 2; Dietary Fats, Unsaturated; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Flax; Lignans; Male; Random Allocation; Rats; Rats, Inbred F344 | 2006 |
Effect of dietary apigenin on colonic ornithine decarboxylase activity, aberrant crypt foci formation, and tumorigenesis in different experimental models.
Topics: Animals; Apigenin; Azoxymethane; Caco-2 Cells; Carcinogens; Colon; Colonic Neoplasms; Diet; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Humans; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Precancerous Conditions; Random Allocation | 2006 |
Chemoprevention of colon carcinogenesis by polyethylene glycol: suppression of epithelial proliferation via modulation of SNAIL/beta-catenin signaling.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; beta Catenin; Cadherins; Cell Proliferation; Colon; Colonic Neoplasms; Cyclin D1; Epithelial Cells; Humans; Male; Polyethylene Glycols; Rats; Rats, Inbred F344; Signal Transduction; Snail Family Transcription Factors; Transcription Factors; Tumor Cells, Cultured | 2006 |
Circumvention and reactivation of the p53 oncogene checkpoint in mouse colon tumors.
Topics: Animals; Apoptosis; Azoxymethane; Carcinogens; Cell Line, Tumor; Colonic Neoplasms; Genes, p53; Imidazoles; Male; Mice; Mice, Inbred Strains; Piperazines; Proto-Oncogene Proteins c-mdm2; Tumor Suppressor Protein p53 | 2006 |
Suppression of azoxymethane-induced colon cancer development in rats by a cyclooxygenase-1 selective inhibitor, mofezolac.
Topics: Animals; Azoxymethane; Carcinoma; Colonic Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Isoxazoles; Male; Membrane Proteins; Rats; Rats, Inbred F344 | 2006 |
Effects of quercetin and beta-carotene supplementation on azoxymethane-induced colon carcinogenesis and inflammatory responses in rats fed with high-fat diet rich in omega-6 fatty acids.
Topics: Animals; Azoxymethane; beta Carotene; Carcinogens; Colonic Neoplasms; Cyclooxygenase 2; Dietary Fats; Fatty Acids, Omega-6; Male; Models, Biological; Nitric Oxide Synthase Type II; Quercetin; Rats; Rats, Sprague-Dawley; Vitamins | 2006 |
Catalpa seed oil rich in 9t,11t,13c-conjugated linolenic acid suppresses the development of colonic aberrant crypt foci induced by azoxymethane in rats.
Topics: Animals; Azoxymethane; Bignoniaceae; Body Weight; Cholesterol; Colon; Colonic Neoplasms; Cyclooxygenase 2; Immunohistochemistry; Intestinal Mucosa; Linolenic Acids; Lipids; Liver; Male; Organ Size; Plant Oils; Precancerous Conditions; Proliferating Cell Nuclear Antigen; Rats; Seeds; Triglycerides | 2006 |
Carbohydrate digestibility predicts colon carcinogenesis in azoxymethane-treated rats.
Topics: Animals; Azoxymethane; Carcinogens; Cecum; Colonic Neoplasms; Dietary Carbohydrates; Dietary Fats; Dietary Fiber; Digestion; Disease Models, Animal; Fructose; Hydrogen-Ion Concentration; Inulin; Lipid Metabolism; Male; Oligosaccharides; Organ Size; Precancerous Conditions; Random Allocation; Rats; Rats, Inbred F344; Solubility; Triglycerides | 2006 |
Flax seed oil and flax seed meal reduce the formation of aberrant crypt foci (ACF) in azoxymethane-induced colon cancer in Fisher 344 male rats.
Topics: Animals; Azoxymethane; Cecum; Colon; Colonic Neoplasms; Dietary Fats, Unsaturated; Dose-Response Relationship, Drug; Glutathione Transferase; Intestinal Mucosa; Linseed Oil; Liver; Male; Oils; Organ Size; Precancerous Conditions; Rats; Rats, Inbred F344; Soybean Oil | 2007 |
Diet supplemented with citrus unshiu segment membrane suppresses chemically induced colonic preneoplastic lesions and fatty liver in male db/db mice.
Topics: Animals; Azoxymethane; Carcinogens; Cholesterol; Colon; Colonic Neoplasms; Diet; Dietary Supplements; Fatty Liver; Insulin; Leptin; Liver; Male; Mice; Mice, Inbred Strains; Plant Extracts; Precancerous Conditions; Proliferating Cell Nuclear Antigen; Triglycerides | 2007 |
Deoxycholic acid promotes the growth of colonic aberrant crypt foci.
Topics: Animals; Azoxymethane; beta Catenin; Cadherins; Carcinogens; Cell Nucleus; Colon; Colonic Neoplasms; Deoxycholic Acid; Detergents; Hyperplasia; Male; Mice; Mice, Inbred AKR; Precancerous Conditions; Protein Transport | 2007 |
Enhanced estrogenic responses and sensitivity to azoxymethane following dietary soy isoflavone supplementation in older female rats.
Topics: Aging; Animals; Azoxymethane; Colon; Colonic Neoplasms; Dietary Supplements; Estradiol; Estrogen Receptor beta; Female; Glycine max; Isoflavones; Precancerous Conditions; Rats; Rats, Inbred F344 | 2007 |
Mixed tocopherols inhibit azoxymethane-induced aberrant crypt foci in rats.
Topics: alpha-Tocopherol; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoxymethane; Colon; Colonic Neoplasms; Cyclooxygenase Inhibitors; gamma-Tocopherol; Male; Mice; Precancerous Conditions; Random Allocation; Rats; Rats, Inbred F344; Vitamins | 2006 |
Novel mucilage fraction of Sinapis alba L. (mustard) reduces azoxymethane-induced colonic aberrant crypt foci formation in F344 and Zucker obese rats.
Topics: Adhesives; Animals; Antineoplastic Agents, Phytogenic; Azoxymethane; Colon; Colonic Neoplasms; Female; Male; Plant Extracts; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Rats, Zucker; Sinapis | 2007 |
Chemoprevention of aberrant crypt foci in the colon of rats by dietary onion.
Topics: Animals; Azoxymethane; Carcinogens; Chemoprevention; Colonic Neoplasms; Female; Onions; Rats; Rats, Inbred F344 | 2007 |
Effect of azoxymethane and curcumin on transcriptional levels of cyclooxygenase-1 and -2 during initiation of colon carcinogenesis.
Topics: Aging; Animals; Anticarcinogenic Agents; Arachidonic Acid; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Curcumin; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Male; Rats; Rats, Inbred F344; RNA, Messenger | 2007 |
Long-term feeding of various fat diets modulates azoxymethane-induced colon carcinogenesis through Wnt/beta-catenin signaling in rats.
Topics: Animals; Apoptosis; Azoxymethane; beta Catenin; Cell Proliferation; Cell Transformation, Neoplastic; Colonic Neoplasms; Corn Oil; Cyclin D; Cyclins; Dietary Fats; Disease Models, Animal; Fats; Fish Oils; Male; Olive Oil; Plant Oils; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Signal Transduction; Time Factors; Wnt Proteins | 2007 |
Pterostilbene, an active constituent of blueberries, suppresses aberrant crypt foci formation in the azoxymethane-induced colon carcinogenesis model in rats.
Topics: Animals; Azoxymethane; Blueberry Plants; Body Weight; Colonic Neoplasms; Male; Models, Chemical; Mucin-2; Mucins; Nitric Oxide Synthase Type II; Plant Extracts; Proliferating Cell Nuclear Antigen; Rats; Rats, Inbred F344; Stilbenes; Time Factors | 2007 |
Chitosan prevents the development of AOM-induced aberrant crypt foci in mice and suppressed the proliferation of AGS cells by inhibiting DNA synthesis.
Topics: Animals; Azoxymethane; Blotting, Western; Carcinogens; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chitosan; Colonic Neoplasms; DNA Replication; Flow Cytometry; Humans; Jurkat Cells; Male; Mice; Mice, Inbred ICR; Molecular Weight; Precancerous Conditions; Stomach Neoplasms; Time Factors; Urinary Bladder Neoplasms | 2007 |
Epidermal growth factor receptor signaling is required for microadenoma formation in the mouse azoxymethane model of colonic carcinogenesis.
Topics: Adenoma; Animals; Azoxymethane; beta Catenin; Carcinogens; Cell Transformation, Neoplastic; Colonic Neoplasms; Cyclin D1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; ErbB Receptors; Gefitinib; Genes, ras; Male; Mice; Mice, Inbred A; Mutation; Quinazolines; Signal Transduction; Up-Regulation | 2007 |
Study of superoxide dismutase's expression in the colon produced by azoxymethane and inositol hexaphosfate's paper, in mice.
Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Male; Phytic Acid; Precancerous Conditions; Rats; Rats, Wistar; Superoxide Dismutase | 2006 |
Modulation of transforming growth factor beta2 (TGF-beta2) by inositol hexaphosphate in colon carcinogenesis in rats.
Topics: Animals; Azoxymethane; Carcinogenicity Tests; Carcinogens; Colon; Colonic Neoplasms; Disease Models, Animal; Image Processing, Computer-Assisted; Male; Phytic Acid; Rats; Transforming Growth Factor beta2 | 2006 |
Selected fruits reduce azoxymethane (AOM)-induced aberrant crypt foci (ACF) in Fisher 344 male rats.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Blueberry Plants; Colonic Neoplasms; Fruit; Glutathione Transferase; Liver; Lythraceae; Male; Plant Extracts; Precancerous Conditions; Random Allocation; Rats; Rats, Inbred F344 | 2007 |
Chemopreventive effects of lupulone, a hop {beta}-acid, on human colon cancer-derived metastatic SW620 cells and in a rat model of colon carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Disease Models, Animal; Fas Ligand Protein; fas Receptor; Humans; Intestinal Mucosa; Male; Mitochondrial Membranes; Neoplasm Metastasis; Permeability; Plant Preparations; Rats; Rats, Wistar; Receptors, TNF-Related Apoptosis-Inducing Ligand; Terpenes | 2007 |
Ursodeoxycholic acid versus sulfasalazine in colitis-related colon carcinogenesis in mice.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Colitis; Colonic Neoplasms; Cyclooxygenase 2; Disease Models, Animal; Male; Mice; Mice, Inbred ICR; RNA, Messenger; Sulfasalazine; Ursodeoxycholic Acid | 2007 |
Global gene expression analysis of the mouse colonic mucosa treated with azoxymethane and dextran sodium sulfate.
Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Gene Expression; Gene Expression Profiling; Inflammation; Intestinal Mucosa; Male; Mice; Mice, Inbred ICR; Oligonucleotide Array Sequence Analysis | 2007 |
Zapotin, a phytochemical present in a Mexican fruit, prevents colon carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Carcinogens; Cell Division; Cell Line, Tumor; Colon; Colonic Neoplasms; Disease Models, Animal; Dose-Response Relationship, Drug; Flavones; Flow Cytometry; HT29 Cells; Humans; Manilkara; Mice; Mice, Inbred Strains; Precancerous Conditions; Time Factors | 2007 |
Citrus auraptene suppresses azoxymethane-induced colonic preneoplastic lesions in C57BL/KsJ-db/db mice.
Topics: Animals; Antineoplastic Agents; Apoptosis; Azoxymethane; Carcinogens; Cell Division; Citrus; Colonic Neoplasms; Coumarins; Diet; Female; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Phenotype; Precancerous Conditions; Random Allocation | 2007 |
Ursolic acid inhibits the formation of aberrant crypt foci and affects colonic sphingomyelin hydrolyzing enzymes in azoxymethane-treated rats.
Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Dose-Response Relationship, Drug; Female; Intestinal Mucosa; Rats; Rats, Sprague-Dawley; Sphingomyelin Phosphodiesterase; Sphingomyelins; Treatment Outcome; Triterpenes; Tumor Cells, Cultured; Ursolic Acid | 2008 |
Reovirus decreases azoxymethane-induced aberrant crypt foci and colon cancer in a rodent model.
Topics: Adenocarcinoma; Animals; Azoxymethane; Carcinogens; CD8-Positive T-Lymphocytes; Colonic Neoplasms; Female; Lymphocytes; Male; Orthoreovirus; Precancerous Conditions; Rats; Rats, Sprague-Dawley | 2007 |
Green tea selectively targets initial stages of intestinal carcinogenesis in the AOM-ApcMin mouse model.
Topics: Adenoma; Animals; Azoxymethane; Camellia sinensis; Carcinogens; Colonic Neoplasms; Cyclooxygenase 2; Female; Gene Expression Regulation, Neoplastic; Genes, APC; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Plant Extracts | 2007 |
Inducible nitric oxide synthase (iNOS) mediates the early increase of blood supply (EIBS) in colon carcinogenesis.
Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Enzyme Inhibitors; Immunohistochemistry; Light; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Rats; Rats, Inbred F344; Scattering, Radiation; Time Factors | 2007 |
Insulin-like growth factor binding protein-3 inhibits colitis-induced carcinogenesis.
Topics: Animals; Azoxymethane; Colitis; Colonic Neoplasms; Disease Progression; Female; Follow-Up Studies; Insulin-Like Growth Factor Binding Protein 3; Mice; Mice, Transgenic; Neoplasms, Experimental; Treatment Outcome | 2007 |
Guanylyl cyclase C suppresses intestinal tumorigenesis by restricting proliferation and maintaining genomic integrity.
Topics: Animals; Apoptosis; Azoxymethane; beta Catenin; Cell Cycle Proteins; Cell Proliferation; Cell Transformation, Neoplastic; Colonic Neoplasms; Disease Models, Animal; DNA Damage; Gene Expression Regulation, Neoplastic; Genes, APC; Guanylate Cyclase; Intestinal Neoplasms; Intestine, Small; Ki-67 Antigen; Loss of Heterozygosity; Mice; Mice, Knockout; Mutation; Receptors, Enterotoxin; Receptors, Guanylate Cyclase-Coupled; Receptors, Peptide | 2007 |
Colon cancer chemoprevention by a novel NO chimera that shows anti-inflammatory and antiproliferative activity in vitro and in vivo.
Topics: Animals; Apoptosis; Azoxymethane; Cell Count; Cell Line, Tumor; Cell Proliferation; Chemoprevention; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p27; Disulfides; DNA Damage; Enzyme Induction; Flow Cytometry; Humans; Inflammation; Male; Mice; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type II; Poly(ADP-ribose) Polymerases; Precancerous Conditions; Rats; Rats, Inbred F344 | 2007 |
An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progression.
Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Disease Progression; Inflammation Mediators; Mice; Mutagens | 2007 |
S-adenosyl L-methionine inhibits azoxymethane-induced colonic aberrant crypt foci in F344 rats and suppresses human colon cancer Caco-2 cell growth in 3D culture.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Blotting, Western; Caco-2 Cells; Cell Culture Techniques; Cells, Cultured; Collagen; Colon; Colonic Neoplasms; Colonic Polyps; Cyclooxygenase 2; Drug Combinations; Humans; Laminin; Lipopolysaccharides; Male; Maximum Tolerated Dose; Precancerous Conditions; Proteoglycans; Rats; Rats, Inbred F344; S-Adenosylmethionine; Spheroids, Cellular | 2008 |
Strain-specific homeostatic responses during early stages of Azoxymethane-induced colon tumorigenesis in mice.
Topics: Animals; Apoptosis; Azoxymethane; Blotting, Western; Carcinogens; Colon; Colonic Neoplasms; Epithelial Cells; In Situ Nick-End Labeling; Intestinal Mucosa; Male; Mice; Mice, Inbred A; Mice, Inbred AKR; Precancerous Conditions; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2007 |
Increased endocannabinoid levels reduce the development of precancerous lesions in the mouse colon.
Topics: Amidohydrolases; Animals; Azoxymethane; Cannabinoid Receptor Modulators; Caspase 3; Caspase 9; Colon; Colonic Neoplasms; Endocannabinoids; Mass Spectrometry; Mice; Precancerous Conditions; Receptors, Cannabinoid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2008 |
Increased susceptibility of Sf1(+/-) mice to azoxymethane-induced colon tumorigenesis.
Topics: Animals; Azoxymethane; beta Catenin; Colonic Neoplasms; Disease Models, Animal; DNA Primers; DNA-Binding Proteins; Genes, Lethal; Genetic Predisposition to Disease; Genotype; Homeodomain Proteins; Introns; Mice; Mice, Knockout; Nerve Tissue Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA Splicing Factors; Transcription Factors; Transcriptional Activation | 2007 |
Fetal programming of colon cancer in adult rats: correlations with altered neonatal growth trajectory, circulating IGF-I and IGF binding proteins, and testosterone.
Topics: Animals; Animals, Newborn; Azoxymethane; Biomarkers; Caseins; CD3 Complex; Colon; Colonic Neoplasms; Diet; Female; Gene Expression; Genistein; Glucose; Glucose Transporter Type 1; Growth; Insulin; Insulin-Like Growth Factor Binding Proteins; Insulin-Like Growth Factor I; Intestinal Mucosa; Leptin; Male; Models, Animal; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Receptor, IGF Type 1; RNA, Messenger; Soybean Proteins; Testosterone | 2007 |
9trans,11trans conjugated linoleic acid inhibits the development of azoxymethane-induced colonic aberrant crypt foci in rats.
Topics: Animals; Apoptosis; Azoxymethane; Biomarkers, Tumor; Cell Division; Colon; Colonic Neoplasms; Cyclin D1; Cyclooxygenase 2; Disease Models, Animal; Dose-Response Relationship, Drug; Immunohistochemistry; Intestinal Mucosa; Linoleic Acids, Conjugated; Lipids; Male; PPAR gamma; Precancerous Conditions; Random Allocation; Rats; Rats, Inbred F344 | 2007 |
Suppression of azoxymethane-induced colon cancer development in rats by dietary resistant starch.
Topics: Amylose; Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Body Weight; Carcinogens; Cecum; Cell Proliferation; Colon; Colonic Neoplasms; Dietary Carbohydrates; Drinking; Eating; Fatty Acids, Volatile; Feces; Male; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley; Starch | 2007 |
Helicobacter hepaticus promotes azoxymethane-initiated colon tumorigenesis in BALB/c-IL10-deficient mice.
Topics: Adenocarcinoma; Animals; Azoxymethane; Carcinogens; Colitis; Colon; Colonic Neoplasms; Helicobacter hepaticus; Helicobacter Infections; Interleukin-10; Mice; Mice, Inbred BALB C; Mice, Knockout | 2008 |
Tissue zinc levels in precancerous tissue in the gastrointestinal tract of azoxymethane (AOM)-treated rats.
Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Gastrointestinal Tract; Precancerous Conditions; Rats; Rats, Wistar; Superoxide Dismutase; Zinc | 2008 |
Beta-ionone inhibits colonic aberrant crypt foci formation in rats, suppresses cell growth, and induces retinoid X receptor-alpha in human colon cancer cells.
Topics: Animals; Azoxymethane; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Gene Expression Regulation, Neoplastic; Humans; Male; Molecular Structure; Norisoprenoids; Rats; Rats, Inbred F344; Retinoid X Receptor alpha; RNA, Messenger | 2008 |
Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis.
Topics: Animals; Azoxymethane; Carcinoma; Cell Transformation, Neoplastic; Chronic Disease; Colitis, Ulcerative; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Etanercept; Immunoglobulin G; Mice; Mice, Mutant Strains; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Tumor Necrosis Factor Decoy Receptors; Tumor Necrosis Factor-alpha | 2008 |
The effect of kefir on glutathione (GSH), malondialdehyde (MDA) and nitric oxide (NO) levels in mice with colonic abnormal crypt formation (ACF) induced by azoxymethane (AOM).
Topics: Animal Feed; Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Cultured Milk Products; Digestive System; Female; Glutathione; Liver; Male; Malondialdehyde; Mice; Mice, Inbred BALB C; Models, Animal; Nitric Oxide; Probiotics; Random Allocation; Spleen | 2008 |
Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon.
Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Gene Expression Regulation, Neoplastic; Genes, ras; Immunoblotting; Immunohistochemistry; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Precancerous Conditions; Reverse Transcriptase Polymerase Chain Reaction | 2008 |
The potential of sphingomyelin as a chemopreventive agent in AOM-induced colon cancer model: wild-type and p53+/- mice.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Carcinogens; Cell Division; Colonic Neoplasms; DNA Damage; Epithelial Cells; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Sphingomyelin Phosphodiesterase; Sphingomyelins; Tumor Suppressor Protein p53 | 2008 |
Suppressive effects of nobiletin on hyperleptinemia and colitis-related colon carcinogenesis in male ICR mice.
Topics: Animals; Antioxidants; Azoxymethane; Carcinogens; Cell Division; Cell Line, Tumor; Colitis; Colonic Neoplasms; Flavones; Humans; Leptin; Male; Mice; Mice, Inbred ICR | 2008 |
Peroxisome proliferator-activated receptor gamma (PPARgamma) suppresses colonic epithelial cell turnover and colon carcinogenesis through inhibition of the beta-catenin/T cell factor (TCF) pathway.
Topics: Active Transport, Cell Nucleus; Animals; Azoxymethane; beta Catenin; Caco-2 Cells; Cell Proliferation; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Epithelial Cells; Female; HT29 Cells; Humans; Mice; Mice, Inbred BALB C; Mice, Knockout; Pioglitazone; PPAR gamma; Protein Binding; RNA Interference; Signal Transduction; TCF Transcription Factors; Thiazolidinediones; Time Factors; Transfection | 2008 |
Chemoprevention of colon carcinogenesis by oleanolic acid and its analog in male F344 rats and modulation of COX-2 and apoptosis in human colon HT-29 cancer cells.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Cell Proliferation; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; HT29 Cells; Humans; Macrophages; Male; Mice; Nitric Oxide Synthase Type II; Oleanolic Acid; Precancerous Conditions; Rats; Rats, Inbred F344 | 2008 |
Epidermal growth factor receptor controls flat dysplastic aberrant crypt foci development and colon cancer progression in the rat azoxymethane model.
Topics: Animals; Azoxymethane; CCAAT-Enhancer-Binding Protein-beta; Colonic Neoplasms; Cyclin D; Cyclins; Disease Progression; ErbB Receptors; Gefitinib; Male; Precancerous Conditions; Quinazolines; Rats; Rats, Inbred F344; STAT3 Transcription Factor; Transcription Factor AP-1 | 2008 |
Altered gene expression in rat colonic adenocarcinomas induced in an azoxymethane plus 2-amino-1-methyl-6-phenylimidazo[4,5-b]- pyridine initiation-promotion model.
Topics: Adenocarcinoma; Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Dose-Response Relationship, Drug; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Imidazoles; Male; Oligonucleotide Array Sequence Analysis; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; STAT1 Transcription Factor; Vascular Endothelial Growth Factor A | 2007 |
Dietary cooked navy beans and their fractions attenuate colon carcinogenesis in azoxymethane-induced ob/ob mice.
Topics: Adenocarcinoma; Adenoma; Animals; Anticarcinogenic Agents; Azoxymethane; Carcinogens; Colonic Neoplasms; Fabaceae; Male; Mice; Mice, Obese; Plant Extracts; Random Allocation; Solubility | 2008 |
Ursodeoxycholic acid suppresses Cox-2 expression in colon cancer: roles of Ras, p38, and CCAAT/enhancer-binding protein.
Topics: Animals; Azoxymethane; CCAAT-Enhancer-Binding Protein-beta; Cells, Cultured; Chemoprevention; Cholic Acid; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dietary Supplements; Gene Expression Regulation, Neoplastic; Genes, ras; p38 Mitogen-Activated Protein Kinases; Signal Transduction; Transcription Factors; Transfection; Ursodeoxycholic Acid | 2008 |
Genetic ablation of M3 muscarinic receptors attenuates murine colon epithelial cell proliferation and neoplasia.
Topics: Animals; Azoxymethane; Cell Proliferation; Cell Transformation, Neoplastic; Colonic Neoplasms; Epithelial Cells; Gene Expression Regulation, Neoplastic; Humans; In Situ Hybridization; Mice; Mice, Transgenic; Models, Biological; Models, Genetic; Receptor, Muscarinic M3; Signal Transduction | 2008 |
Effect of dietary wheat bran and dehydrated citrus fiber on azoxymethane-induced intestinal carcinogenesis in Fischer 344 rats.
Topics: Adenocarcinoma; Adenoma; Animals; Azo Compounds; Azoxymethane; Cellulose; Colonic Neoplasms; Dietary Fiber; Edible Grain; Fruit; Intestinal Neoplasms; Male; Neoplasms, Experimental; Rats; Rats, Inbred F344 | 1981 |
Human colon cells: culture and in vitro transformation.
Topics: Antigens, Viral, Tumor; Azoxymethane; Cell Transformation, Neoplastic; Cells, Cultured; Colon; Colonic Neoplasms; Fibroblasts; Humans; Lectins; Simian virus 40 | 1984 |
Alkaline phosphatase isozymes in large intestines and large intestinal tumors of Fischer 344 rats.
Topics: Alkaline Phosphatase; Animals; Antibodies, Monoclonal; Antigen-Antibody Complex; Azoxymethane; Colonic Neoplasms; Cross Reactions; Intestine, Large; Intestine, Small; Isoenzymes; Kinetics; Rats; Rats, Inbred F344 | 1984 |
The effect of vasopressin and hepatic artery ligation on the blood supply to normal and metastatic liver tissue.
Topics: Animals; Azoxymethane; Blood Flow Velocity; Blood Pressure; Colonic Neoplasms; Dose-Response Relationship, Drug; Hepatic Artery; Ligation; Liver; Liver Neoplasms; Male; Portal Vein; Rats; Rats, Inbred Strains; Vasopressins | 1984 |
The effect of deuterium substitution on carcinogenesis by azoxymethane.
Topics: Animals; Azo Compounds; Azoxymethane; Biotransformation; Colonic Neoplasms; Deuterium; Kidney Neoplasms; Liver Neoplasms; Male; Neoplasms, Experimental; Oxidation-Reduction; Rats; Rats, Inbred F344; Structure-Activity Relationship | 1984 |
Tumor promotion by dietary fat in azoxymethane-induced colon carcinogenesis in female F344 rats: influence of amount and source of dietary fat.
Topics: Adenocarcinoma; Adenoma; Animals; Azoxymethane; Body Weight; Colonic Neoplasms; Dietary Fats; Feces; Female; Intestinal Neoplasms; Oils; Rats; Rats, Inbred F344; Sterols | 1984 |
Effect of neomycin on azoxymethane-induced colon carcinogenesis in F344 rats.
Topics: Animals; Azo Compounds; Azoxymethane; Body Weight; Colon; Colonic Neoplasms; Feces; Female; Neomycin; Rats; Rats, Inbred F344; Sterols | 1984 |
The relationship between intestinal hyperplasia and carcinogenesis.
Topics: Animals; Azoxymethane; Bile Acids and Salts; Cell Division; Cocarcinogenesis; Colon; Colonic Neoplasms; Dimethylhydrazines; Hyperplasia; Intestinal Mucosa; Intestine, Small; Male; Postoperative Complications; Rats; Rats, Inbred Strains; Rectal Neoplasms; Rectum | 1984 |
Androgens as promoters of colon carcinogenesis.
Topics: Androgens; Animals; Azoxymethane; Carcinoembryonic Antigen; Castration; Colonic Neoplasms; Male; Neoplasms, Experimental; Rats; Rats, Inbred F344 | 1983 |
Adaptation and carcinogenesis in defunctioned rat colon: divergent effects of faeces and bile acids.
Topics: Animals; Azoxymethane; Body Weight; Cocarcinogenesis; Colonic Neoplasms; Deoxycholic Acid; Feces; Intestinal Neoplasms; Intestines; Male; Rats; Rats, Inbred Strains; Therapeutic Irrigation | 1983 |
Studies of experimental colon cancer.
Topics: Animals; Azoxymethane; Colectomy; Colonic Neoplasms; Colonic Polyps; Disease Models, Animal; Ileum; Rats; Rectum; Research Design | 1984 |
Adaptation to jejunoileal bypass promotes experimental colorectal carcinogenesis.
Topics: Adaptation, Physiological; Animals; Azoxymethane; Cocarcinogenesis; Colon; Colonic Neoplasms; Ileum; Jejunum; Male; Postoperative Complications; Rats; Rats, Inbred Strains; Rectal Neoplasms; Rectum | 1984 |
Relative effects of ileal resection and bypass on intestinal adaptation and carcinogenesis.
Topics: Adaptation, Physiological; Animals; Azoxymethane; Cell Division; Colonic Neoplasms; Ileum; Intestinal Neoplasms; Intestines; Male; Postoperative Complications; Rats; Rats, Inbred Strains; Rectal Neoplasms | 1984 |
Effect of dietary unsaturated and saturated fats on azoxymethane-induced colon carcinogenesis in rats.
Topics: Animals; Azoxymethane; Body Weight; Colon; Colonic Neoplasms; Dietary Fats; Fatty Acids; Intestinal Mucosa; Linoleic Acid; Linoleic Acids; Liver; Male; Phospholipids; Rats; Rats, Inbred Strains; Stearic Acids | 1984 |
The cocarcinogenic effect of intrarectal deoxycholate in rats is reduced by oral metronidazole.
Topics: Animals; Azoxymethane; Cocarcinogenesis; Colonic Neoplasms; Deoxycholic Acid; Intestines; Male; Metronidazole; Rats; Rats, Inbred Strains; Rectal Neoplasms | 1984 |
Detection of early neoplastic changes in experimentally induced colorectal cancer using scanning electron microscopy and cell kinetic studies.
Topics: Adenoma; Animals; Azoxymethane; Cell Division; Colon; Colonic Neoplasms; Intestinal Mucosa; Male; Microscopy, Electron, Scanning; Precancerous Conditions; Rats; Rats, Inbred Strains; Rectal Neoplasms | 1984 |
Effect of dietary cholesterol on azoxymethane-induced colon carcinogenesis in rats.
Topics: Animals; Azo Compounds; Azoxymethane; Bile Acids and Salts; Cholesterol; Cholesterol, Dietary; Cocarcinogenesis; Colonic Neoplasms; Feces; Male; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Sterols | 1983 |
Morphogenesis of colonic carcinoma. Ultrastructural studies of azoxymethane-induced early lesions in colon epithelium of Fischer 344 rats.
Topics: Animals; Azo Compounds; Azoxymethane; Colon; Colonic Neoplasms; Intestinal Mucosa; Models, Biological; Precancerous Conditions; Rats; Rats, Inbred F344 | 1982 |
Colon epithelium. II. In vivo studies of colon carcinogenesis. Light microscopic, histochemical, and ultrastructural studies of histogenesis of azoxymethane-induced colon carcinomas in Fischer 344 rats.
Topics: Animals; Azo Compounds; Azoxymethane; Carcinoma; Colonic Neoplasms; Epithelium; Intestinal Mucosa; Male; Neoplasms, Experimental; Precancerous Conditions; Rats; Rats, Inbred F344 | 1981 |
Effect of beta-glucuronidase inhibitor on azoxymethane-induced colonic carcinogenesis in rats.
Topics: Animals; Azo Compounds; Azoxymethane; Benzylidene Compounds; Biotransformation; Cocarcinogenesis; Colonic Neoplasms; Glucuronidase; Intestinal Mucosa; Neoplasms, Experimental; Rats | 1982 |
Intestinal adaptation and experimental carcinogenesis after partial colectomy. Increased tumour yields are confined to the anastomosis.
Topics: Adaptation, Physiological; Animals; Azoxymethane; Colectomy; Colonic Neoplasms; Hyperplasia; Intestines; Male; Neoplasms, Multiple Primary; Postoperative Complications; Rats; Rats, Inbred Strains; Rectal Neoplasms | 1982 |
The effect of hepatic arterial ligation on spontaneously developing colorectal liver metastases in the rat.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Hepatic Artery; Ligation; Liver Circulation; Liver Neoplasms; Male; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Rectal Neoplasms | 1982 |
Effect of vitamin B12-deficiency in colon carcinogenesis.
Topics: Animals; Azo Compounds; Azoxymethane; Colonic Neoplasms; Diet; Duodenal Neoplasms; Kidney; Liver; Male; Rats; Vitamin B 12; Vitamin B 12 Deficiency | 1980 |
Monoclonal antibody recognizing a determinant on type 2 chain blood group A and B oligosaccharides detects oncodevelopmental changes in azoxymethane-induced rat colon tumors and human colon cancer cell lines.
Topics: ABO Blood-Group System; Animals; Antibodies, Monoclonal; Azoxymethane; Blotting, Western; Carbohydrate Sequence; Colonic Neoplasms; Epitopes; Female; Glycoproteins; Humans; Immunohistochemistry; Mice; Molecular Sequence Data; Neoplasms, Experimental; Oligosaccharides; Rats; Rats, Sprague-Dawley | 1995 |
Chemoprevention by galanin against colon carcinogenesis induced by azoxymethane in Wistar rats.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Carcinoma; Cell Division; Colonic Neoplasms; Galanin; Neuropeptides; Peptides; Rats; Rats, Wistar | 1995 |
1H MR visible lipids in colon tissue from normal and carcinogen-treated rats.
Topics: Animals; Azoxymethane; Colon; Colonic Neoplasms; Disease Models, Animal; Intestinal Mucosa; Lipid Metabolism; Magnetic Resonance Spectroscopy; Protons; Rats; Rats, Sprague-Dawley | 1995 |
Absence of p53 gene mutations in rat colon carcinomas induced by azoxymethane.
Topics: Adenocarcinoma; Animals; Azoxymethane; Base Sequence; Carcinogens; Colonic Neoplasms; DNA Primers; Genes, p53; Male; Molecular Sequence Data; Mutagens; Point Mutation; Polymorphism, Single-Stranded Conformational; Rats; Rats, Inbred F344 | 1995 |
Varying effect of dietary lipids and azoxymethane on early stages of colon carcinogenesis: enumeration of aberrant crypt foci and proliferative indices.
Topics: Analysis of Variance; Animals; Azoxymethane; Carcinogens; Cell Division; Colon; Colonic Neoplasms; Dietary Fats; Disease Models, Animal; Male; Random Allocation; Rats; Rats, Sprague-Dawley | 1995 |
Regional chemoprevention of carcinogen-induced tumors in rat colon.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Colonic Neoplasms; Eflornithine; Ellagic Acid; Male; Piroxicam; Pyrazines; Rats; Rats, Inbred F344; Thiones; Thiophenes | 1995 |
Increased N-myristoyltransferase activity observed in rat and human colonic tumors.
Topics: Acyltransferases; Animals; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Humans; Male; Neoplasms, Experimental; Protein Processing, Post-Translational; Random Allocation; Rats; Rats, Sprague-Dawley | 1995 |
Mechanism of action of chemoprotective ursodeoxycholate in the azoxymethane model of rat colonic carcinogenesis: potential roles of protein kinase C-alpha, -beta II, and -zeta.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Cholic Acid; Cholic Acids; Colonic Neoplasms; Isoenzymes; Male; Protein Kinase C; Rats; Rats, Inbred F344; Ursodeoxycholic Acid | 1995 |
Histochemical studies of progressive p53 mutations during colonic carcinogenesis in Sprague-Dawley rats induced by N-methyl-N-nitro-nitrosoguanidine or azoxymethane.
Topics: Adenocarcinoma; Animals; Azoxymethane; Cell Nucleus; Colonic Neoplasms; Cytoplasm; Epithelium; Gene Expression; Genes, p53; Immunohistochemistry; Male; Methylnitronitrosoguanidine; Mutation; Rats; Rats, Sprague-Dawley; Tumor Suppressor Protein p53 | 1994 |
Suppression of azoxymethane-induced colonic aberrant crypt foci by dietary exposure to a novel synthesized retinoidal butenolide, 5-hydroxy-4-(2-phenyl-(E)ethenyl)-2(5H)-furanone, in rats.
Topics: 4-Butyrolactone; Animals; Anticarcinogenic Agents; Azoxymethane; Biogenic Polyamines; Biomarkers, Tumor; Body Weight; Cell Division; Colonic Neoplasms; Epithelium; Intestinal Mucosa; Liver; Male; Nucleolus Organizer Region; Organ Size; Ornithine Decarboxylase; Rats; Rats, Inbred F344; Retinoids; Silver Staining | 1995 |
1 alpha,25-Dihydroxy-16-ene-23-yne-26,27-hexafluorocholecalciferol, a noncalcemic analogue of 1 alpha,25-dihydroxyvitamin D3, inhibits azoxymethane-induced colonic tumorigenesis.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Calcitriol; Cell Transformation, Neoplastic; Colonic Neoplasms; Male; Rats; Rats, Inbred F344 | 1995 |
Attenuation of vasoactive intestinal peptide enhancement of colon carcinogenesis by ornithine decarboxylase inhibitor.
Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Adenoma; Animals; Azoxymethane; Colonic Neoplasms; Diamines; Male; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Random Allocation; Rats; Rats, Wistar; Vasoactive Intestinal Peptide | 1995 |
Enhancement by peptide histidine isoleucine of experimental carcinogenesis in the colon of rats induced by azoxymethane.
Topics: Adenocarcinoma; Animals; Azoxymethane; Body Weight; Colon; Colonic Neoplasms; Drug Synergism; Gastrins; Intestinal Mucosa; Peptide PHI; Rats; Rats, Wistar | 1995 |
Effects of apple pectin on fecal bacterial enzymes in azoxymethane-induced rat colon carcinogenesis.
Topics: Adenocarcinoma; Animals; Azoxymethane; beta-Glucosidase; Body Weight; Carcinoma, Signet Ring Cell; Colonic Neoplasms; Feces; Fruit; Glucuronidase; Male; Pectins; Rats; Tryptophanase | 1995 |
Dietary lipid and iron modify normal colonic mucosa without affecting phospholipase A2 activity.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Dietary Fats; Intestinal Mucosa; Iron; Male; Phospholipases A; Phospholipases A2; Rats; Rats, Inbred F344 | 1995 |
Chemoprevention of azoxymethane-induced colon carcinogenesis by dietary feeding of S-methyl methane thiosulfonate in male F344 rats.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Biogenic Polyamines; Bromodeoxyuridine; Colon; Colonic Neoplasms; Diet; Male; Methyl Methanesulfonate; Nucleolus Organizer Region; Ornithine Decarboxylase; Rats; Rats, Inbred F344 | 1995 |
Enhancement of experimental colon carcinogenesis by dietary 6-phenylhexyl isothiocyanate.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Colonic Neoplasms; Diet; Dinoprostone; Isothiocyanates; Male; Phosphatidylinositols; Phospholipases A; Phospholipases A2; Rats; Rats, Inbred F344; Type C Phospholipases | 1995 |
Hypergastrinemia in rats with azoxymethane-induced colon cancers.
Topics: Animals; Azoxymethane; Cell Division; Colonic Neoplasms; Gastrins; Male; Ornithine Decarboxylase; Rats; Rats, Wistar; Thymidine | 1995 |
Characterisation of aberrant crypt foci in carcinogen-treated rats: association with intestinal carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Dimethylhydrazines; Female; Intestinal Mucosa; Mucins; Precancerous Conditions; Rats; Rats, Sprague-Dawley | 1995 |
Chemopreventive effects of calcium but not aspirin supplementation in cholic acid-promoted colon carcinogenesis: correlation with intermediate endpoints.
Topics: Animals; Anticarcinogenic Agents; Aspirin; Azoxymethane; Biomarkers, Tumor; Body Weight; Calcium; Cholic Acid; Cholic Acids; Colon; Colonic Neoplasms; Eating; Intestinal Mucosa; Male; Ornithine Decarboxylase; Protein Kinase C; Rats; Rats, Inbred F344 | 1995 |
Chemoprevention by amiloride of experimental carcinogenesis in rat colon induced by azoxymethane.
Topics: Amiloride; Animals; Anticarcinogenic Agents; Azoxymethane; Colon; Colonic Neoplasms; Dose-Response Relationship, Drug; Male; Ornithine Decarboxylase; Rats; Rats, Wistar; Time Factors | 1995 |
Chemoprevention of colon carcinogenesis by phenylethyl-3-methylcaffeate.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Body Weight; Caffeic Acids; Colon; Colonic Neoplasms; Evaluation Studies as Topic; Intestinal Mucosa; Lipoxygenase; Male; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide Phospholipase C; Phospholipases A; Phospholipases A2; Phosphoric Diester Hydrolases; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred F344 | 1995 |
Selective preservation of protein kinase C-zeta in the chemoprevention of azoxymethane-induced colonic tumors by piroxicam.
Topics: Administration, Oral; Animals; Azoxymethane; Cell Transformation, Neoplastic; Colonic Neoplasms; Enzyme Induction; Gene Expression Regulation, Neoplastic; Male; Neoplasm Proteins; Piroxicam; Protein Kinase C; Rats; Rats, Inbred F344; Signal Transduction | 1995 |
Inhibitory effect of Bifidobacterium longum cultures on the azoxymethane-induced aberrant crypt foci formation and fecal bacterial beta-glucuronidase.
Topics: Animals; Azoxymethane; Bacteria; Bifidobacterium; Colonic Neoplasms; Feces; Glucuronidase; Male; Precancerous Conditions; Rats; Rats, Inbred F344 | 1994 |
Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Curcumin; Dinoprostone; Drug Screening Assays, Antitumor; Isoenzymes; Lipoxygenase; Male; Phospholipase C gamma; Phospholipases A; Phospholipases A2; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred F344; Type C Phospholipases | 1995 |
Inhibition of aberrant crypt growth by non-steroidal anti-inflammatory agents and differentiation agents in the rat colon.
Topics: Acetaminophen; Adenoma; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Aspirin; Azoxymethane; Colonic Neoplasms; Drug Screening Assays, Antitumor; Fenretinide; Ibuprofen; Isotretinoin; Male; Piroxicam; Precancerous Conditions; Rats; Rats, Inbred F344 | 1995 |
Effect of beta-carotene and wheat bran fiber on colonic aberrant crypt and tumor formation in rats exposed to azoxymethane and high dietary fat.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; beta Carotene; Body Weight; Carotenoids; Cocarcinogenesis; Colonic Neoplasms; Dietary Fats; Dietary Fiber; Dose-Response Relationship, Drug; Male; Precancerous Conditions; Rats; Rats, Inbred F344; Triticum | 1995 |
The effect of bile acids and piroxicam on MHC antigen expression in rat colonocytes during colon cancer development.
Topics: Animals; Azoxymethane; Bile Acids and Salts; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Histocompatibility Antigens; Male; Piroxicam; Rats; Rats, Inbred F344 | 1994 |
Further investigation of the effect of cholic acid on the induction, growth characteristics and stability of aberrant crypt foci in rat colon.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Body Weight; Cell Division; Cholic Acid; Cholic Acids; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Male; Mitosis; Precancerous Conditions; Rats; Rats, Sprague-Dawley | 1995 |
Modifying effects of naturally occurring products on the development of colonic aberrant crypt foci induced by azoxymethane in F344 rats.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Biogenic Polyamines; Colon; Colonic Neoplasms; Intestinal Mucosa; Male; Nucleolus Organizer Region; Oleanolic Acid; Ornithine Decarboxylase; Precancerous Conditions; Rats; Rats, Inbred F344; Sesquiterpenes | 1995 |
Chemoprevention of colon carcinogenesis by sulindac, a nonsteroidal anti-inflammatory agent.
Topics: Adenocarcinoma; Animals; Azoxymethane; Colonic Neoplasms; Drug Screening Assays, Antitumor; Hydroxyeicosatetraenoic Acids; Male; Pharmaceutical Vehicles; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Diacylglycerol-Lyase; Phosphatidylinositol Phosphates; Phosphoinositide Phospholipase C; Phospholipases A; Phospholipases A2; Phosphoric Diester Hydrolases; Prostaglandins; Rats; Rats, Inbred F344; Sulindac; Thromboxanes | 1995 |
Chemoprevention of digestive organs carcinogenesis by natural product protocatechuic acid.
Topics: 4-Nitroquinoline-1-oxide; Animals; Azoxymethane; Colonic Neoplasms; Diethylnitrosamine; Digestive System Neoplasms; Female; Humans; Hydroxybenzoates; In Vitro Techniques; Liver Neoplasms; Male; Methylnitrosourea; Mouth Neoplasms; Rats; Rats, Inbred F344 | 1995 |
Transglutaminase in azoxymethane-induced colon cancer in the rat.
Topics: Adenocarcinoma; Adenoma; Animals; Azoxymethane; Colon; Colonic Neoplasms; Immunoenzyme Techniques; Intestine, Small; Male; Rats; Rats, Sprague-Dawley; Transglutaminases | 1995 |
Increased cell proliferation of azoxymethane-induced aberrant crypt foci of rat colon.
Topics: Animals; Azoxymethane; Bromodeoxyuridine; Cell Division; Colon; Colonic Neoplasms; Epithelium; Kinetics; Male; Mitotic Index; Nuclear Proteins; Precancerous Conditions; Proliferating Cell Nuclear Antigen; Rats; Rats, Inbred F344 | 1994 |
Chemoprevention of azoxymethane-induced colonic carcinogenesis by supplemental dietary ursodeoxycholic acid.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Colonic Neoplasms; Diet; Male; Rats; Rats, Inbred F344; Ursodeoxycholic Acid | 1994 |
Inhibitory effects of dietary curcumin on forestomach, duodenal, and colon carcinogenesis in mice.
Topics: Adenocarcinoma; Adenoma; Adenoma, Villous; Animals; Azoxymethane; Benzo(a)pyrene; Carcinogens; Colonic Neoplasms; Curcumin; Duodenal Neoplasms; Female; Male; Methylnitronitrosoguanidine; Mice; Stomach Neoplasms | 1994 |
Cell kinetics and polyamine enzymes in the intestinal mucosa of rats with azoxymethane induced tumours.
Topics: Amine Oxidase (Copper-Containing); Animals; Azoxymethane; Cell Division; Colonic Neoplasms; Intestinal Mucosa; Intestinal Neoplasms; Intestine, Small; Male; Ornithine Decarboxylase; Polyamines; Rats; Rats, Wistar | 1994 |
Modulation of azoxymethane-induced mutational activation of ras protooncogenes by chemopreventive agents in colon carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Base Sequence; Colon; Colonic Neoplasms; Eflornithine; Genes, ras; Intestinal Mucosa; Male; Molecular Sequence Data; Mutation; Piroxicam; Polymerase Chain Reaction; Rats; Rats, Inbred F344 | 1994 |
Resistance of aberrant crypt foci to apoptosis induced by azoxymethane in rats chronically fed cholic acid.
Topics: Animals; Apoptosis; Azoxymethane; Bromodeoxyuridine; Cholic Acid; Cholic Acids; Colonic Neoplasms; DNA; Male; Precancerous Conditions; Rats; Rats, Sprague-Dawley | 1994 |
Suppression of azoxymethane-induced rat colon aberrant crypt foci by dietary protocatechuic acid.
Topics: Animals; Anticarcinogenic Agents; Antigens, Nuclear; Azoxymethane; Colon; Colonic Neoplasms; Diet; Epithelium; Hydroxybenzoates; Intestinal Mucosa; Male; Nuclear Proteins; Nucleolus Organizer Region; Ornithine Decarboxylase; Precancerous Conditions; Rats; Rats, Inbred F344; Silver Staining | 1994 |
Aberrant crypt foci and colon tumors in F344 rats have similar increases in proliferative activity.
Topics: Adenocarcinoma; Animals; Azoxymethane; beta-N-Acetylhexosaminidases; Bromodeoxyuridine; Cell Division; Colon; Colonic Neoplasms; Histocytochemistry; Immunohistochemistry; Male; Rats; Rats, Inbred F344 | 1994 |
Monoamine oxidase B inhibitor enhances experimental carcinogenesis in rat colon induced by azoxymethane.
Topics: Animals; Azoxymethane; Clorgyline; Colon; Colonic Neoplasms; Drug Synergism; Epithelium; Male; Norepinephrine; Pargyline; Rats; Rats, Wistar | 1994 |
Sequential analysis of K-ras mutations in aberrant crypt foci and colonic tumors induced by azoxymethane in Fischer-344 rats on high-risk diet.
Topics: Adenocarcinoma; Animals; Azoxymethane; Colonic Neoplasms; Diet; DNA, Neoplasm; Genes, ras; Male; Mutagenesis; Rats; Rats, Inbred F344 | 1994 |
Asbestos induces aberrant crypt foci in the colon of rats.
Topics: Animals; Asbestos, Crocidolite; Asbestos, Serpentine; Azoxymethane; Carcinogenicity Tests; Colonic Neoplasms; Female; Mice; Precancerous Conditions; Rats; Rats, Inbred F344 | 1993 |
Use of azoxymethane-induced foci of aberrant crypts in rat colon to identify potential cancer chemopreventive agents.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; beta-N-Acetylhexosaminidases; Body Weight; Circadian Rhythm; Colon; Colonic Neoplasms; Drug Screening Assays, Antitumor; Male; Rats; Rats, Inbred F344 | 1994 |
Omeprazole inhibits colorectal carcinogenesis induced by azoxymethane in rats.
Topics: Animals; Azoxymethane; Body Weight; Colonic Neoplasms; Eating; Female; Gastrins; Omeprazole; Rats; Rats, Sprague-Dawley; Rectal Neoplasms | 1993 |
Immunohistochemical demonstration of mutant p53 tumour suppressor gene product in aberrant crypt foci.
Topics: Adenocarcinoma; Animals; Azoxymethane; Cell Nucleus; Colonic Neoplasms; Cytoplasm; Genes, Tumor Suppressor; Immunohistochemistry; Male; Mutation; Rats; Rats, Sprague-Dawley; Tumor Suppressor Protein p53 | 1993 |
The influence of the interaction of sutures with the mucosa on tumour formation at colonic anastomoses in rats.
Topics: Anastomosis, Surgical; Animals; Azoxymethane; Cell Division; Cocarcinogenesis; Colonic Neoplasms; Intestinal Mucosa; Male; Rats; Rats, Sprague-Dawley; Sutures; Wound Healing | 1993 |
Chemoprevention of colon carcinogenesis by organosulfur compounds.
Topics: Acetylcysteine; Allyl Compounds; Anethole Trithione; Animals; Anticarcinogenic Agents; Azoxymethane; Colonic Neoplasms; Disulfides; Glucuronosyltransferase; Glutathione Transferase; Male; NAD(P)H Dehydrogenase (Quinone); Rats; Rats, Inbred F344; Taurine | 1993 |
Inhibitory effect of aspirin on azoxymethane-induced colon carcinogenesis in F344 rats.
Topics: Adenocarcinoma; Adenoma; Animals; Anticarcinogenic Agents; Aspirin; Azoxymethane; Body Weight; Colonic Neoplasms; Dinoprostone; Male; Rats; Rats, Inbred F344 | 1993 |
Chemoprevention of colon carcinogenesis by the natural product of a simple phenolic compound protocatechuic acid: suppressing effects on tumor development and biomarkers expression of colon tumorigenesis.
Topics: Adenocarcinoma; Adenoma; Animals; Antineoplastic Agents; Azoxymethane; Biomarkers, Tumor; Cell Division; Colon; Colonic Neoplasms; Drug Screening Assays, Antitumor; Hydroxybenzoates; Intestinal Mucosa; Liver; Male; Nucleolus Organizer Region; Organ Size; Ornithine Decarboxylase; Rats; Rats, Inbred F344 | 1993 |
Inhibitory effect of caffeic acid esters on azoxymethane-induced biochemical changes and aberrant crypt foci formation in rat colon.
Topics: Animals; Anticarcinogenic Agents; Arachidonic Acid; Azoxymethane; Caffeic Acids; Colon; Colonic Neoplasms; Male; Ornithine Decarboxylase; Precancerous Conditions; Protein-Tyrosine Kinases; Rats; Rats, Inbred F344 | 1993 |
Alpha 1-antitrypsin as a biomarker in azoxymethane induced intestinal tumors in F344 rats.
Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Adenoma; alpha 1-Antitrypsin; Animals; Azoxymethane; Biomarkers, Tumor; Colonic Neoplasms; Intestinal Neoplasms; Intestine, Small; Male; Rats; Rats, Inbred F344; Sensitivity and Specificity | 1993 |
Ability of aberrant crypt foci characteristics to predict colonic tumor incidence in rats fed cholic acid.
Topics: Animals; Azoxymethane; Carcinogens; Cholic Acid; Cholic Acids; Colon; Colonic Neoplasms; Diet; Incidence; Male; Precancerous Conditions; Rats; Rats, Sprague-Dawley | 1993 |
K-ras mutations in aberrant crypt foci, adenomas and adenocarcinomas during azoxymethane-induced colon carcinogenesis.
Topics: Adenocarcinoma; Adenoma; Animals; Azoxymethane; Base Sequence; Blotting, Southern; Colon; Colonic Neoplasms; Female; Genes, ras; Molecular Sequence Data; Mutation; Polymerase Chain Reaction; Rats; Rats, Inbred F344 | 1993 |
Enhancement by the tricyclic antidepressant, desipramine, of experimental carcinogenesis in rat colon induced by azoxymethane.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Desipramine; Drug Synergism; Male; Norepinephrine; Rats; Rats, Wistar | 1993 |
Reduction of aberrant crypt foci induced in rat colon with azoxymethane or methylnitrosourea by feeding cholic acid.
Topics: Analysis of Variance; Animals; Azoxymethane; Body Weight; Cell Division; Cholic Acid; Cholic Acids; Colonic Neoplasms; Intestinal Mucosa; Male; Methylnitrosourea; Precancerous Conditions; Random Allocation; Rats; Rats, Sprague-Dawley | 1993 |
Effect of exercise on intestinal tumour development in the male Fischer rat after exposure to azoxymethane.
Topics: Animals; Azoxymethane; Body Mass Index; Colonic Neoplasms; Lipids; Male; Physical Conditioning, Animal; Rats; Rats, Inbred F344; Weight Gain | 1993 |
Effects of all-trans retinoic acid as a potential chemopreventive agent on the formation of azoxymethane-induced aberrant crypt foci: differential expression of c-myc and c-fos MRNA and protein.
Topics: Animals; Azoxymethane; Body Weight; Colon; Colonic Neoplasms; Genes, fos; Genes, myc; Male; Precancerous Conditions; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-myc; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tretinoin | 1993 |
Intermediate biomarkers of colon cancer: modulation of expression of ras oncogene by chemopreventive agents during azoxymethane induced colon carcinogenesis.
Topics: Affinity Labels; Animals; Azoxymethane; Biomarkers, Tumor; Blotting, Western; Colonic Neoplasms; Eflornithine; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Guanosine Triphosphate; Male; Piroxicam; Proto-Oncogene Proteins p21(ras); Rats | 1993 |
Initiation and promotion of colonic aberrant crypt foci in rats by 5-hydroxymethyl-2-furaldehyde in thermolyzed sucrose.
Topics: Animals; Azoxymethane; Colon; Colonic Neoplasms; Female; Furaldehyde; Hot Temperature; Precancerous Conditions; Rats; Rats, Inbred F344; Sucrose | 1993 |
Sucrose enhancement of the early steps of colon carcinogenesis in mice.
Topics: Animals; Azoxymethane; Cell Division; Cocarcinogenesis; Colonic Neoplasms; Female; Fructose; Glucose; Mice; Mice, Inbred C57BL; Mitosis; Precancerous Conditions; Species Specificity; Sucrose | 1993 |
Chemopreventive effect of oltipraz during different stages of experimental colon carcinogenesis induced by azoxymethane in male F344 rats.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Azoxymethane; Colonic Neoplasms; Drug Administration Schedule; Drug Screening Assays, Antitumor; Male; Pyrazines; Rats; Rats, Inbred F344; Thiones; Thiophenes | 1993 |
Effects of caloric restriction and dietary fat on epithelial cell proliferation in rat colon.
Topics: Animals; Azoxymethane; Cell Division; Colon; Colonic Neoplasms; Corn Oil; Energy Intake; Epithelial Cells; Male; Rats; Rats, Inbred F344 | 1993 |
Two types of putative preneoplastic lesions identified by hexosaminidase activity in whole-mounts of colons from F344 rats treated with carcinogen.
Topics: Animals; Azoxymethane; Carcinogens; Clinical Enzyme Tests; Colon; Colonic Neoplasms; Hexosaminidases; Injections, Subcutaneous; Male; Microvilli; Phytic Acid; Precancerous Conditions; Rats; Rats, Inbred F344 | 1993 |
Metabolic alterations of zinc and prostaglandins in both human and animal colonic tumor cells.
Topics: Animals; Azoxymethane; Base Sequence; Carcinogens; Colonic Neoplasms; Dinoprost; Dinoprostone; DNA, Neoplasm; Epidermal Growth Factor; Gene Expression Regulation, Enzymologic; Humans; Molecular Sequence Data; Prostaglandin-Endoperoxide Synthases; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Zinc | 1995 |
Chemoprevention of colon cancer by dietary curcumin.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Curcumin; Diet; Intestinal Mucosa; Lipoxygenase; Male; Ornithine Decarboxylase; Prostaglandin-Endoperoxide Synthases; Protein-Tyrosine Kinases; Rats; Rats, Inbred F344 | 1995 |
Molecular markers in chemoprevention of colon cancer. Inhibition of expression of ras-p21 and p53 by sulindac during azoxymethane-induced colon carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Biomarkers, Tumor; Blotting, Western; Carcinogens; Colon; Colonic Neoplasms; Intestinal Mucosa; Male; Proto-Oncogene Proteins p21(ras); Rats; Rats, Inbred F344; Sulindac; Tumor Suppressor Protein p53 | 1995 |
Cyclooxygenase-1 and cyclooxygenase-2 gene expression in human colorectal adenocarcinomas and in azoxymethane induced colonic tumours in rats.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Animals; Azoxymethane; Base Sequence; Carcinogens; Colonic Neoplasms; Colorectal Neoplasms; Female; Gene Expression; Humans; Male; Middle Aged; Molecular Sequence Data; Oligonucleotide Probes; Polymerase Chain Reaction; Prostaglandin-Endoperoxide Synthases; Rats; RNA, Messenger | 1996 |
Suppression of azoxymethane-induced aberrant crypt foci in rat colon by nimesulide, a selective inhibitor of cyclooxygenase 2.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Intestinal Mucosa; Isoenzymes; Male; Neoplasms, Experimental; Precancerous Conditions; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred F344; Sulfonamides | 1996 |
Suppression of azoxymethane-induced rat colon carcinogenesis by dietary administration of naturally occurring xanthophylls astaxanthin and canthaxanthin during the postinitiation phase.
Topics: Animals; Azoxymethane; beta Carotene; Bromodeoxyuridine; Canthaxanthin; Carcinogens; Carotenoids; Colon; Colonic Neoplasms; Diet; Incidence; Intestinal Mucosa; Male; Ornithine Decarboxylase; Polyamines; Rats; Rats, Inbred F344; Xanthophylls | 1995 |
Unexpected antagonistic action of 3,2'-dimethyl-4-aminobiphenyl on aberrant crypt induction by 1,2-dimethylhydrazine or azoxymethane in rat colon.
Topics: 1,2-Dimethylhydrazine; Aminobiphenyl Compounds; Animals; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Diet; Dimethylhydrazines; Male; Precancerous Conditions; Rats; Rats, Inbred F344; Rats, Inbred Lew | 1995 |
The influence of high and low molecular weight chitosan on colonic cell proliferation and aberrant crypt foci development in CF1 mice.
Topics: Animals; Azoxymethane; Carcinogens; Cell Division; Chitin; Chitosan; Colon; Colonic Neoplasms; Dietary Fiber; Female; Mice; Molecular Weight; Precancerous Conditions; Random Allocation; Solubility | 1996 |
Lack of aberrant crypt promotion and of mutagenicity in extracts of cooked casein, a colon cancer-promoting food.
Topics: Animals; Azoxymethane; Carcinogens; Caseins; Chromatography, High Pressure Liquid; Colon; Colonic Neoplasms; Female; Hot Temperature; Mutagenicity Tests; Mutagens; Rats; Rats, Inbred F344; Salmonella typhimurium | 1995 |
Increased cyclooxygenase-2 levels in carcinogen-induced rat colonic tumors.
Topics: Animals; Azoxymethane; Blotting, Northern; Blotting, Western; Colon; Colonic Neoplasms; Cyclooxygenase 2; Intestinal Mucosa; Isoenzymes; Male; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred F344; RNA, Messenger | 1996 |
A rapid dual organ rat carcinogenesis bioassay for evaluating the chemoprevention of breast and colon cancer.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Breast Neoplasms; Carcinogenicity Tests; Carcinogens; Cocarcinogenesis; Colonic Neoplasms; Dietary Fats; Dietary Fiber; Drug Screening Assays, Antitumor; Evaluation Studies as Topic; Female; Methylnitrosourea; Phytic Acid; Rats; Rats, Sprague-Dawley | 1996 |
Effect of amount and types of dietary fat on intestinal bacterial 7 alpha-dehydroxylase and phosphatidylinositol-specific phospholipase C and colonic mucosal diacylglycerol kinase and PKC activities during stages of colon tumor promotion.
Topics: Animals; Azoxymethane; Bacterial Proteins; Bile Acids and Salts; Carcinogens; Cecum; Cocarcinogenesis; Colon; Colonic Neoplasms; Corn Oil; Diacylglycerol Kinase; Dietary Fats; Fish Oils; Hydroxysteroid Dehydrogenases; Intestinal Mucosa; Male; Oxidoreductases; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide Phospholipase C; Phosphoric Diester Hydrolases; Phosphotransferases (Alcohol Group Acceptor); Precancerous Conditions; Protein Kinase C; Rats; Rats, Inbred F344; Steroid Hydroxylases | 1996 |
Inhibitory effects of d-limonene on the development of colonic aberrant crypt foci induced by azoxymethane in F344 rats.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Cyclohexenes; Drinking; Drug Screening Assays, Antitumor; Limonene; Male; Nucleolus Organizer Region; Ornithine Decarboxylase; Precancerous Conditions; Rats; Rats, Inbred F344; Terpenes | 1996 |
Piroxicam-induced regression of azoxymethane-induced aberrant crypt foci and prevention of colon cancer in rats.
Topics: Adenocarcinoma; Adenoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Drug Screening Assays, Antitumor; Male; Piroxicam; Precancerous Conditions; Rats; Rats, Inbred F344 | 1996 |
Dietary fiber and the chemopreventive modelation of colon carcinogenesis.
Topics: Animals; Azoxymethane; beta Carotene; Carcinogens; Carotenoids; Colon; Colonic Neoplasms; Diet; Dietary Fats; Dietary Fiber; Genes, ras; Humans; Intestinal Mucosa; Phytic Acid; Precancerous Conditions; Psyllium; Rats; Rats, Inbred F344; Risk Factors | 1996 |
Inability of low- or high-fat diet to modulate late stages of colon carcinogenesis in Sprague-Dawley rats.
Topics: Animals; Azoxymethane; Body Weight; Carcinogens; Cocarcinogenesis; Colonic Neoplasms; Dietary Fats; Male; Precancerous Conditions; Rats; Rats, Sprague-Dawley | 1996 |
Suppressing effect of perilla oil on azoxymethane-induced foci of colonic aberrant crypts in rats.
Topics: alpha-Linolenic Acid; Animals; Anticarcinogenic Agents; Azoxymethane; Body Weight; Carcinogens; Cell Division; Colon; Colonic Neoplasms; Dinoprost; Dose-Response Relationship, Drug; Eating; Fatty Acids, Omega-3; Intestinal Mucosa; Male; Nucleolus Organizer Region; Phospholipids; Plant Oils; Precancerous Conditions; Rats; Rats, Inbred F344; Silver Staining | 1996 |
Effects of the phytochemicals, curcumin and quercetin, upon azoxymethane-induced colon cancer and 7,12-dimethylbenz[a]anthracene-induced mammary cancer in rats.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Azoxymethane; Body Weight; Carcinogens; Colonic Neoplasms; Curcumin; Drug Interactions; Female; Male; Mammary Neoplasms, Experimental; Plant Extracts; Precancerous Conditions; Quercetin; Rats; Rats, Inbred F344; Rats, Sprague-Dawley | 1996 |
Protein kinase C isoforms in the chemopreventive effects of a novel vitamin D3 analogue in rat colonic tumorigenesis.
Topics: Adenocarcinoma; Adenoma; Animals; Anticarcinogenic Agents; Azoxymethane; Calcitriol; Chemoprevention; Colon; Colonic Neoplasms; Down-Regulation; Isoenzymes; Male; Protein Kinase C; Rats; Rats, Inbred F344; Up-Regulation | 1996 |
Re: Pereira, M.A., Barnes, L.H., Rassman, V.L., Kelloff, G.V. and Steele, V.E. (1994). Use of azoxymethane-induced foci of aberrant crypts in rat colon to identify potential cancer chemopreventive agents. Carcinogenesis, 15, 1049-1054.
Topics: Analysis of Variance; Animals; Anticarcinogenic Agents; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Drug Evaluation, Preclinical; Rats | 1996 |
The effect of dietary fat on the promotion of mammary and colon cancer in a dual-organ rat carcinogenesis model.
Topics: Adenocarcinoma; Adenoma; Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Dietary Fats; Energy Intake; Female; Mammary Neoplasms, Experimental; Methylnitrosourea; Rats; Rats, Sprague-Dawley; Time Factors | 1996 |
Effects of repeated boluses of sucrose on proliferation and on AOM-induced aberrant crypt foci in rat colon.
Topics: Animals; Azoxymethane; Bile Acids and Salts; Carcinogens; Cell Division; Colonic Neoplasms; Fatty Acids; Female; Intestinal Mucosa; Mucins; Rats; Rats, Inbred F344; Sialomucins; Starch; Sucrose | 1996 |
Dietary guar gum alters colonic microbial fermentation in azoxymethane-treated rats.
Topics: Analysis of Variance; Animals; Azoxymethane; Butyrates; Carcinogens; Colon; Colonic Neoplasms; Dietary Fiber; Dose-Response Relationship, Drug; Fatty Acids, Volatile; Female; Fermentation; Galactans; Incidence; Mannans; Plant Gums; Rats; Rats, Inbred F344; Regression Analysis; Time Factors | 1996 |
Suppressing effects of 6-(2,5-dichlorophenyl)-2,4-diamino-1,3,5-triazine and related synthetic compounds on azoxymethane-induced aberrant crypt foci in rat colon.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Colonic Neoplasms; Diet; Epithelium; Intestinal Mucosa; Male; Ornithine Decarboxylase; Polyamines; Precancerous Conditions; Rats; Rats, Inbred F344; Triazines | 1996 |
Synergistic suppression of azoxymethane-induced foci of colonic aberrant crypts by the combination of beta-carotene and perilla oil in rats.
Topics: Administration, Oral; alpha-Linolenic Acid; Animals; Anticarcinogenic Agents; Azoxymethane; beta Carotene; Biomarkers; Carcinogens; Colon; Colonic Neoplasms; Drug Synergism; Genes, ras; Intestinal Mucosa; Liver; Male; Nucleolus Organizer Region; Olive Oil; Plant Oils; Rats; Rats, Inbred F344; Retinoids; Vitamin A | 1996 |
Growth features of aberrant crypt foci that resist modulation by cholic acid.
Topics: Analysis of Variance; Animals; Anticarcinogenic Agents; Azoxymethane; Carcinogens; Cholic Acid; Cholic Acids; Colon; Colonic Neoplasms; Diet; Intestinal Mucosa; Male; Precancerous Conditions; Rats; Rats, Sprague-Dawley | 1996 |
Evaluation of cyclooxygenase-2 inhibitor for potential chemopreventive properties in colon carcinogenesis.
Topics: Animals; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Screening Assays, Antitumor; Isoenzymes; Male; Precancerous Conditions; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred F344; Rats, Inbred Lew; Sulindac | 1996 |
Modulation of colonic aberrant crypt foci and proliferative indexes in colon and prostate glands of rats by vitamin E.
Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Azoxymethane; Cell Division; Colon; Colonic Neoplasms; Male; Precancerous Conditions; Proliferating Cell Nuclear Antigen; Prostate; Rats; Rats, Inbred F344; Vitamin E | 1996 |
Effects of diet and ethanol treatment on azoxymethane-induced liver and gastrointestinal neoplasia of male rats.
Topics: Alcohol Drinking; Animals; Azoxymethane; Carcinogens; Cocarcinogenesis; Colonic Neoplasms; Diet; Duodenal Neoplasms; Gastrointestinal Neoplasms; Liver Neoplasms, Experimental; Male; Parenteral Nutrition, Total; Rats; Rats, Sprague-Dawley | 1996 |
Insulin promotion of colon tumors in rats.
Topics: Animals; Azoxymethane; Blood Glucose; Body Weight; Carcinogenicity Tests; Carcinogens; Colonic Neoplasms; Dose-Response Relationship, Drug; Hypoglycemic Agents; Insulin; Male; Rats; Rats, Inbred F344 | 1996 |
Dietary fat and colon cancer: modulating effect of types and amount of dietary fat on ras-p21 function during promotion and progression stages of colon cancer.
Topics: Animals; Azoxymethane; Blotting, Western; Carcinogens; Colon; Colonic Neoplasms; Corn Oil; Dietary Fats; Fish Oils; Intestinal Mucosa; Male; Neoplasms, Experimental; Proto-Oncogene Proteins p21(ras); Rats; Rats, Inbred F344 | 1997 |
Chemoprevention of colon carcinogenesis by dietary perillyl alcohol.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Colonic Neoplasms; Diet; Male; Monoterpenes; Rats; Rats, Inbred F344; Terpenes | 1997 |
Bifidobacterium longum and lactulose suppress azoxymethane-induced colonic aberrant crypt foci in rats.
Topics: Animal Feed; Animals; Anticarcinogenic Agents; Azoxymethane; Bifidobacterium; Biomarkers; Carcinogens; Colon; Colonic Diseases; Colonic Neoplasms; Diarrhea; Diet; Glutathione Transferase; Hydrogen-Ion Concentration; Intestinal Mucosa; Isoenzymes; Lactulose; Liver; Male; Precancerous Conditions; Rats; Rats, Inbred F344 | 1997 |
Diet and carcinogen alter the fecal microbial populations of rats.
Topics: Aging; Animals; Anti-Infective Agents, Local; Azoxymethane; Bacteria; Carcinogens; Cellulose; Cetrimonium; Cetrimonium Compounds; Colon; Colonic Neoplasms; Colony Count, Microbial; Coloring Agents; Congo Red; Corn Oil; Culture Media; Dietary Fats; Dietary Fiber; Feces; Fish Oils; Male; Pectins; Rats; Rats, Sprague-Dawley | 1997 |
Chemoprevention of colon cancer by organoselenium compounds and impact of high- or low-fat diets.
Topics: Adenocarcinoma; Analysis of Variance; Animals; Anticarcinogenic Agents; Azoxymethane; Colonic Neoplasms; Cyanates; Dietary Fats; Dose-Response Relationship, Drug; Incidence; Logistic Models; Male; Neoplasm Invasiveness; Organoselenium Compounds; Rats; Rats, Inbred F344 | 1997 |
Insulin injections promote the growth of aberrant crypt foci in the colon of rats.
Topics: Animals; Azoxymethane; Body Composition; Carcinogens; Colon; Colonic Neoplasms; Eating; Female; Insulin; Mucins; Rats; Rats, Inbred F344; Sialomucins; Weight Gain | 1997 |
Increased expression of inducible and endothelial constitutive nitric oxide synthases in rat colon tumors induced by azoxymethane.
Topics: Adenocarcinoma; Animals; Azoxymethane; Colonic Neoplasms; Endothelium; Enzyme Induction; Immunoblotting; Immunohistochemistry; Male; Nitric Oxide Synthase; Rats; Rats, Inbred F344 | 1997 |
Modulation of apoptosis by sulindac, curcumin, phenylethyl-3-methylcaffeate, and 6-phenylhexyl isothiocyanate: apoptotic index as a biomarker in colon cancer chemoprevention and promotion.
Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Biomarkers, Tumor; Caffeic Acids; Carcinogens; Colonic Neoplasms; Curcumin; Isothiocyanates; Male; Rats; Rats, Inbred F344; Sulindac | 1997 |
Cooked casein promotes colon cancer in rats, may be because of mucosal abrasion.
Topics: Alkaline Phosphatase; Animals; Azoxymethane; Bile Acids and Salts; Caseins; Colonic Neoplasms; Feces; Intestinal Mucosa; Precancerous Conditions; Rats; Rats, Inbred F344 | 1997 |
Effect of soya bean saponins on azoxymethane-induced preneoplastic lesions in the colon of mice.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Glycine max; Male; Mice; Precancerous Conditions; Saponins | 1997 |
Colon cancer in rats and diet in the Sonoran desert region of Mexico.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Dietary Fiber; Incidence; Male; Mexico; Rats; Rats, Sprague-Dawley | 1996 |
Aberrant crypts as a biomarker for colon cancer: evaluation of potential chemopreventive agents in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Azoxymethane; Biomarkers, Tumor; Carcinogens; Cell Differentiation; Cell Division; Chemoprevention; Colon; Colonic Neoplasms; Coloring Agents; Evaluation Studies as Topic; Forecasting; Intestinal Mucosa; Male; Methylene Blue; Minerals; Predictive Value of Tests; Rats; Rats, Inbred F344; Sensitivity and Specificity; Vitamins | 1996 |
Chemoprevention of azoxymethane-induced rat colon carcinogenesis by the naturally occurring flavonoids, diosmin and hesperidin.
Topics: Animals; Antineoplastic Agents; Azoxymethane; Colonic Neoplasms; Diosmin; Drug Administration Schedule; Drug Combinations; Hesperidin; Intestinal Mucosa; Male; Organ Size; Ornithine Decarboxylase; Polyamines; Rats; Rats, Inbred F344 | 1997 |
Expression of bcl-2, bax, and bcl-XL proteins in azoxymethane-induced rat colonic adenocarcinomas.
Topics: Adenocarcinoma; Animals; Azoxymethane; bcl-2-Associated X Protein; bcl-X Protein; Blotting, Western; Carcinogens; Colon; Colonic Neoplasms; Immunohistochemistry; Intestinal Mucosa; Male; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Reference Values | 1997 |
Assessment of mutations in Ki-ras and p53 in colon cancers from azoxymethane- and dimethylhydrazine-treated rats.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Dimethylhydrazines; Genes, p53; Genes, ras; Male; Mutagens; Polymorphism, Single-Stranded Conformational; Rats; Rats, Inbred F344 | 1997 |
Inhibition by wheat bran cereals of the development of aberrant crypt foci and colon tumours.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Dietary Fiber; Food, Formulated; Hyperplasia; Intestinal Mucosa; Male; Precancerous Conditions; Rats; Rats, Inbred F344 | 1997 |
Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Carcinogens; Colonic Neoplasms; Dinoprostone; Male; Rats; Rats, Inbred F344; Sulindac | 1997 |
Suppression of azoxymethane-induced rat colon carcinoma development by a fish oil component, docosahexaenoic acid (DHA).
Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Docosahexaenoic Acids; Lipids; Male; Precancerous Conditions; Rats; Rats, Inbred F344 | 1997 |
Chemopreventive agents-induced regression of azoxymethane-induced aberrant crypt foci with the recovery of hexosaminidase activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Azoxymethane; beta-N-Acetylhexosaminidases; Carcinogens; Colonic Neoplasms; Curcumin; Male; Precancerous Conditions; Rats; Rats, Inbred F344 | 1997 |
Inhibition of azoxymethane-initiated colon tumor by bovine lactoferrin administration in F344 rats.
Topics: Adenocarcinoma; Adenoma; Animals; Anticarcinogenic Agents; Azoxymethane; Carcinoma; Cattle; Colonic Neoplasms; Incidence; Intestinal Neoplasms; Intestine, Large; Intestine, Small; Lactoferrin; Male; Rats; Rats, Inbred F344 | 1997 |
Dietary fat and colon cancer: modulation of cyclooxygenase-2 by types and amount of dietary fat during the postinitiation stage of colon carcinogenesis.
Topics: Animals; Azoxymethane; Body Weight; Carcinogens; Colonic Neoplasms; Corn Oil; Cyclooxygenase 1; Cyclooxygenase 2; Fish Oils; Intestinal Mucosa; Isoenzymes; Male; Membrane Proteins; Neoplasm Proteins; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred F344 | 1997 |
Enhancement of experimental colon cancer by genistein.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Dinoprost; Drug Synergism; F2-Isoprostanes; Genistein; Hydroxyprostaglandin Dehydrogenases; Intestinal Mucosa; Isoflavones; Male; Neoplasms, Experimental; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred F344 | 1997 |
The role of apoptosis in the modulation of colon carcinogenesis by dietary fat and by the organoselenium compound 1,4-phenylenebis(methylene)selenocyanate.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Carcinogens; Colonic Neoplasms; Dietary Fats; Male; Organoselenium Compounds; Rats; Rats, Inbred F344 | 1997 |
Dietary fat and fiber modulate the effect of carcinogen on colonic protein kinase C lambda expression in rats.
Topics: Animals; Azoxymethane; Base Sequence; Carcinogens; Colon; Colonic Neoplasms; Dietary Fiber; Fish Oils; Gene Expression Regulation, Enzymologic; Humans; Isoenzymes; Male; Mice; Molecular Sequence Data; Protein Kinase C; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1997 |
Effect of intestinal bacteria on formation of azoxymethane-induced aberrant crypt foci in the rat colon.
Topics: Animals; Azoxymethane; Bacteroides fragilis; Bifidobacterium; Body Weight; Clostridium perfringens; Colonic Neoplasms; Culture Media; Drinking; Escherichia coli; Guanine; Injections, Subcutaneous; Intestinal Mucosa; Lactobacillus acidophilus; Male; Rats; Rats, Sprague-Dawley | 1997 |
Wheat bran diet reduces tumor incidence in a rat model of colon cancer independent of effects on distal luminal butyrate concentrations.
Topics: Animals; Avena; Azoxymethane; Body Weight; Butyrates; Carcinogens; Colon; Colonic Neoplasms; Diet; Dietary Fiber; Disease Models, Animal; Dose-Response Relationship, Drug; Eating; Fatty Acids, Volatile; Feces; Hydrogen-Ion Concentration; Incidence; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Triticum; Weight Gain | 1997 |
Regressive effects of various chemopreventive agents on azoxymethane-induced aberrant crypt foci in the rat colon.
Topics: 4-Butyrolactone; Animals; Anticarcinogenic Agents; Azoxymethane; Body Weight; Carcinogens; Chemoprevention; Chlorogenic Acid; Colonic Neoplasms; Drug Administration Schedule; Male; Methyl Methanesulfonate; Piroxicam; Rats; Rats, Inbred F344; Retinoids | 1997 |
Chemoprevention of azoxymethane-induced rat colon carcinogenesis by a xanthine oxidase inhibitor, 1'-acetoxychavicol acetate.
Topics: Animal Feed; Animals; Anticarcinogenic Agents; Azoxymethane; Benzyl Alcohols; Biomarkers, Tumor; Carcinogens; Chemoprevention; Colon; Colonic Neoplasms; Enzyme Inhibitors; Glutathione Transferase; Intestinal Mucosa; Male; NAD(P)H Dehydrogenase (Quinone); Ornithine Decarboxylase; Polyamines; Rats; Rats, Inbred F344; Terpenes; Time Factors; Xanthine Oxidase | 1997 |
Prevention by retinoids of azoxymethane-induced tumors and aberrant crypt foci and their modulation of cell proliferation in the colon of rats.
Topics: Alitretinoin; Animals; Anticarcinogenic Agents; Azoxymethane; Cell Division; Colonic Neoplasms; Fenretinide; Male; Precancerous Conditions; Proliferating Cell Nuclear Antigen; Rats; Rats, Inbred F344; Tretinoin | 1997 |
Citrus auraptene inhibits chemically induced colonic aberrant crypt foci in male F344 rats.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Citrus; Colonic Neoplasms; Coumarins; Glutathione Transferase; Male; NAD(P)H Dehydrogenase (Quinone); Ornithine Decarboxylase; Precancerous Conditions; Rats; Rats, Inbred F344 | 1997 |
Dry beans inhibit azoxymethane-induced colon carcinogenesis in F344 rats.
Topics: Adenocarcinoma; Adenoma; Animals; Azoxymethane; Carcinogens; Caseins; Colonic Neoplasms; Dietary Fiber; Fabaceae; Male; Plants, Medicinal; Rats; Rats, Inbred F344; Weight Gain | 1997 |
Effect of tea extracts, polyphenols, and epigallocatechin gallate on azoxymethane-induced colon cancer.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Catechin; Colonic Neoplasms; Flavonoids; Male; Phenols; Phytotherapy; Plant Extracts; Polymers; Rats; Rats, Inbred F344; Tea | 1998 |
Beta-catenin is frequently mutated and demonstrates altered cellular location in azoxymethane-induced rat colon tumors.
Topics: Adenocarcinoma; Animals; Azoxymethane; Base Sequence; beta Catenin; Carcinogens; Colonic Neoplasms; Cytoskeletal Proteins; Male; Molecular Sequence Data; Neoplasm Proteins; Neoplasms, Experimental; Point Mutation; Polymerase Chain Reaction; Rats; Rats, Inbred F344; Trans-Activators | 1998 |
Inhibitory effect of NS-398, a selective cyclooxygenase-2 inhibitor, on azoxymethane-induced aberrant crypt foci in colon carcinogenesis of F344 rats.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Body Weight; Carcinogens; Colon; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Immunohistochemistry; Isoenzymes; Liver; Male; Nitrobenzenes; Organ Size; Polymerase Chain Reaction; Precancerous Conditions; Proliferating Cell Nuclear Antigen; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred F344; RNA, Messenger; Sulfonamides | 1997 |
AOM-induced mouse colon tumors do not express full-length APC protein.
Topics: Adenoma; Adenomatous Polyposis Coli Protein; Animals; Azoxymethane; Carcinoma in Situ; Colonic Neoplasms; Cytoskeletal Proteins; Female; Fluorescent Antibody Technique, Indirect; Intestinal Polyps; Male; Mice; Molecular Weight; Mutation; Neoplasm Proteins; Neoplasms, Experimental | 1997 |
Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Celecoxib; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Intestinal Mucosa; Isoenzymes; Male; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Inbred F344; Sulfonamides | 1998 |
The nuclear eicosanoid receptor, PPARgamma, is aberrantly expressed in colonic cancers.
Topics: Adenocarcinoma; Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Eicosanoids; Gene Expression Regulation, Neoplastic; Humans; Male; Nuclear Proteins; Protein Biosynthesis; Rats; Rats, Inbred F344; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; RNA, Messenger; Transcription Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1998 |
Effect of black tea on azoxymethane-induced colon cancer.
Topics: Animals; Azoxymethane; Carcinogens; Carcinoma; Carcinoma in Situ; Colonic Neoplasms; Dose-Response Relationship, Drug; Incidence; Male; Neoplasm Invasiveness; Peyer's Patches; Rats; Rats, Inbred F344; Tea; Time Factors | 1998 |
Fish oil blocks azoxymethane-induced rat colon tumorigenesis by increasing cell differentiation and apoptosis rather than decreasing cell proliferation.
Topics: Adenocarcinoma; Aging; Animals; Apoptosis; Azoxymethane; Carcinogens; Cell Differentiation; Cell Division; Colon; Colonic Neoplasms; Dietary Fats; Dietary Fiber; Fish Oils; Male; Rats; Rats, Sprague-Dawley | 1998 |
Non-invasive detection of fecal protein kinase C betaII and zeta messenger RNA: putative biomarkers for colon cancer.
Topics: Animals; Azoxymethane; Biomarkers; Colonic Neoplasms; Feces; Intestinal Mucosa; Isoenzymes; Male; Polymerase Chain Reaction; Protein Kinase C; Protein Kinase C beta; Rats; Rats, Sprague-Dawley; RNA, Messenger; RNA, Neoplasm | 1998 |
Effect of Bifidobacterium longum and inulin on gut bacterial metabolism and carcinogen-induced aberrant crypt foci in rats.
Topics: Ammonia; Animals; Azoxymethane; Bacteria; beta-Glucosidase; Bifidobacterium; Cecum; Colonic Neoplasms; Glucuronidase; Hydrogen-Ion Concentration; Intestinal Mucosa; Inulin; Male; Precancerous Conditions; Probiotics; Rats; Rats, Sprague-Dawley | 1998 |
Chemopreventive effect of squalene on colon cancer.
Topics: Animals; Azoxymethane; Body Weight; Colonic Neoplasms; Male; Precancerous Conditions; Rats; Rats, Inbred F344; Squalene; Sulindac | 1998 |
Effect of calcium on azoxymethane-induced aberrant crypt foci and cell proliferation in the colon of rats.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Body Weight; Calcium; Carcinogens; Cell Division; Colon; Colonic Neoplasms; Dose-Response Relationship, Drug; Eating; Male; Precancerous Conditions; Proliferating Cell Nuclear Antigen; Rats; Rats, Inbred F344; Risk Factors | 1998 |
Effect of dietary deoxycholic acid and cholesterol on fecal steroid concentration and its impact on the colonic crypt cell proliferation in azoxymethane-treated rats.
Topics: Animals; Azoxymethane; Bile Acids and Salts; Body Weight; Carcinogens; Cell Division; Cholesterol, Dietary; Cocarcinogenesis; Colon; Colonic Neoplasms; Deoxycholic Acid; Eating; Feces; Male; Precancerous Conditions; Rats; Rats, Inbred F344; Steroids | 1998 |
Effect of dietary chlorogenic acid on multiple immune functions and formation of aberrant crypt foci in rats.
Topics: Animals; Antibody Formation; Anticarcinogenic Agents; Azoxymethane; Carcinogens; Chemoprevention; Chlorogenic Acid; Colon; Colonic Neoplasms; Cytotoxicity, Immunologic; Diet; Immune Tolerance; Immunity, Cellular; Killer Cells, Natural; Male; Precancerous Conditions; Rats; Rats, Sprague-Dawley | 1998 |
A fish oil-derived concentrate enriched in eicosapentaenoic and docosahexaenoic acid as ethyl esters inhibits the formation and growth of aberrant crypt foci in rat colon.
Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Docosahexaenoic Acids; Eicosapentaenoic Acid; Male; Rats; Rats, Inbred F344 | 1998 |
Dietary quercetin, immune functions and colonic carcinogenesis in rats.
Topics: Animals; Azoxymethane; Cell Division; Colonic Neoplasms; Female; Killer Cells, Natural; Precancerous Conditions; Quercetin; Rats; Rats, Sprague-Dawley | 1998 |
Inhibition of initiation and early stage development of aberrant crypt foci and enhanced natural killer activity in male rats administered bovine lactoferrin concomitantly with azoxymethane.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Bifidobacterium; Carcinogens; Chemoprevention; Colonic Neoplasms; Drug Administration Schedule; Killer Cells, Natural; Lactoferrin; Male; Neoplasm Staging; Precancerous Conditions; Rats; Rats, Inbred F344 | 1997 |
Evaluation of benzyl selenocyanate glutathione conjugate for potential chemopreventive properties in colon carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Colonic Neoplasms; Cyanates; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Glutathione; Glutathione Transferase; Intestinal Mucosa; Isoenzymes; Male; Membrane Proteins; Organoselenium Compounds; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred F344 | 1998 |
Cyclooxygenase-independent chemoprevention with an aspirin derivative in a rat model of colonic adenocarcinoma.
Topics: Adenocarcinoma; Animals; Aspirin; Azoxymethane; Colonic Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Isoenzymes; Male; Membrane Proteins; Mice; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 1998 |
Slow-release pellets of sodium butyrate increase apoptosis in the colon of rats treated with azoxymethane, without affecting aberrant crypt foci and colonic proliferation.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Biomarkers, Tumor; Butyrates; Butyric Acid; Carcinogens; Colonic Neoplasms; Female; Male; Rats; Rats, Inbred F344; Rats, Sprague-Dawley | 1998 |
Fasting/re-feeding before initiation enhances the growth of aberrant crypt foci induced by azoxymethane in rat colon and rectum.
Topics: Animals; Apoptosis; Azoxymethane; Carcinogens; Cell Division; Colonic Neoplasms; Eating; Fasting; Male; Precancerous Conditions; Rats; Rats, Inbred F344; Rectal Neoplasms; Weight Loss | 1998 |
Dietary fish oil inhibits the expression of farnesyl protein transferase and colon tumor development in rodents.
Topics: Alkyl and Aryl Transferases; Animals; Azoxymethane; Blotting, Western; Body Weight; Carcinogens; Colonic Neoplasms; Dietary Fats; Fish Oils; Rats; Rats, Inbred F344 | 1998 |
Energy metabolism of rat colonocytes changes during the tumorigenic process and is dependent on diet and carcinogen.
Topics: 3-Hydroxybutyric Acid; Animals; Azoxymethane; Butyrates; Butyric Acid; Carcinogens; Cellulose; Colon; Colonic Neoplasms; Diet; Energy Metabolism; Glucose; Glutamine; Hydroxybutyrates; Ketone Bodies; Kinetics; Lactic Acid; Male; Oxidation-Reduction; Pectins; Rats; Rats, Sprague-Dawley | 1998 |
Inhibitory effect of Coptidis Rhizoma and Scutellariae Radix on azoxymethane-induced aberrant crypt foci formation in rat colon.
Topics: Animals; Azoxymethane; Berberine; Colonic Neoplasms; Dose-Response Relationship, Drug; Flavonoids; Male; Plant Extracts; Plants, Medicinal; Precancerous Conditions; Rats; Rats, Inbred F344 | 1998 |
Azoxymethane-induced colon tumors and aberrant crypt foci in mice of different genetic susceptibility.
Topics: Animals; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Disease Susceptibility; Male; Mice; Mice, Inbred A; Mice, Inbred AKR; Mice, Inbred Strains; Phenotype; Precancerous Conditions; Species Specificity | 1998 |
Comparative effects of secondary bile acids, deoxycholic and lithocholic acids, on aberrant crypt foci growth in the postinitiation phases of colon carcinogenesis.
Topics: Animals; Azoxymethane; Carcinogens; Cell Division; Colonic Neoplasms; Deoxycholic Acid; Dietary Fats; Lithocholic Acid; Male; Random Allocation; Rats; Rats, Sprague-Dawley | 1998 |
Inhibition of azoxymethane initiated colon tumor and aberrant crypt foci development by bovine lactoferrin administration in F344 rats.
Topics: Animals; Azoxymethane; Carcinogens; Cattle; Colon; Colonic Neoplasms; Lactoferrin; Male; Neoplasms, Experimental; Precancerous Conditions; Rats; Rats, Inbred F344 | 1998 |
Diverse effect of fish oil on the growth of aberrant crypt foci and tumor multiplicity in F344 rats.
Topics: Animals; Azoxymethane; Carcinogens; Choristoma; Colonic Neoplasms; Corn Oil; Dietary Fats; Fish Oils; Male; Random Allocation; Rats; Rats, Inbred F344 | 1998 |
Long-term analysis of colonic aberrant crypt formation after treatment of Sprague-Dawley rats with azoxymethane.
Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Male; Mutation; Polymorphism, Single-Stranded Conformational; Precancerous Conditions; Rats; Rats, Sprague-Dawley | 1998 |
Chemopreventive effect of aspirin on growth of aberrant crypt foci in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Azoxymethane; Carcinogens; Chemoprevention; Colon; Colonic Neoplasms; Male; Random Allocation; Rats; Rats, Sprague-Dawley | 1998 |
Expression of G protein alpha subunits in normal rat colon and in azoxymethane-induced colonic neoplasms.
Topics: Animals; Azoxymethane; Colon; Colonic Neoplasms; Genes, ras; GTP-Binding Proteins; Male; Mutation; Rats; Rats, Sprague-Dawley | 1998 |
Prevention of precancerous colonic lesions in rats by soy flakes, soy flour, genistein, and calcium.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Calcium; Carcinogens; Colonic Neoplasms; Diet; Genistein; Hyperplasia; Male; Rats; Rats, Inbred F344; Soybean Proteins | 1998 |
Prevention of N-methylnitrosourea-induced colon tumorigenesis by ursodeoxycholic acid in F344 rats.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Carcinogens; Colonic Neoplasms; Dose-Response Relationship, Drug; Female; Methylnitrosourea; Rats; Rats, Inbred F344; Time Factors; Ursodeoxycholic Acid | 1998 |
Suppressive effects of nimesulide, a selective inhibitor of cyclooxygenase-2, on azoxymethane-induced colon carcinogenesis in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoxymethane; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Isoenzymes; Male; Mice; Mice, Inbred ICR; Prostaglandin-Endoperoxide Synthases; Sulfonamides | 1998 |
Altered expression of cyclin D1 and cyclin-dependent kinase 4 in azoxymethane-induced mouse colon tumorigenesis.
Topics: Animals; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; Genes, ras; Immunohistochemistry; Male; Mice; Proto-Oncogene Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 1998 |
Prevention of colon cancer by pre- and probiotics: evidence from laboratory studies.
Topics: Animals; Azoxymethane; Bifidobacterium; Carcinogens; Cell Division; Colonic Neoplasms; Dietary Fiber; Freeze Drying; Intestinal Mucosa; Inulin; Male; Oncogene Protein p21(ras); Ornithine Decarboxylase; Precancerous Conditions; Probiotics; Rats; Rats, Inbred F344 | 1998 |
The chemopreventive role of ursodeoxycholic acid in azoxymethane-treated rats: suppressive effects on enhanced group II phospholipase A2 expression in colonic tissue.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Carcinogens; Colonic Neoplasms; DNA Primers; Gastrointestinal Agents; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Immunoblotting; Male; Phospholipases A; Phospholipases A2; Precancerous Conditions; Prostaglandins; Random Allocation; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Ursodeoxycholic Acid | 1998 |
A comparative analysis of allelic imbalance events in chemically induced rat mammary, colon, and bladder tumors.
Topics: Alleles; Animals; Azoxymethane; Butylhydroxybutylnitrosamine; Carcinogens; Chromosome Mapping; Codon; Colonic Neoplasms; Female; Genes, ras; Genetic Markers; Humans; Loss of Heterozygosity; Male; Mammary Neoplasms, Experimental; Methylnitrosourea; Microsatellite Repeats; Point Mutation; Rats; Rats, Inbred F344; Rats, Inbred WF; Urinary Bladder Neoplasms | 1999 |
Effect of meat (beef, chicken, and bacon) on rat colon carcinogenesis.
Topics: Adipose Tissue; Animals; Azoxymethane; Bile Acids and Salts; Carcinogens; Cattle; Chickens; Colon; Colonic Neoplasms; Diet; Drinking; Eating; Fatty Acids; Feces; Female; Iron; Meat; Random Allocation; Rats; Rats, Inbred F344; Risk Factors; Swine; Viscera; Weight Gain | 1998 |
Coordinate regulation of cyclooxygenase-2 and TGF-beta1 in replication error-positive colon cancer and azoxymethane-induced rat colonic tumors.
Topics: Animals; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Enzyme Induction; Epithelial Cells; Humans; Immunohistochemistry; Intestinal Mucosa; Isoenzymes; Liver Neoplasms; Male; Membrane Proteins; Neoplasm Proteins; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred F344; RNA, Messenger; Transforming Growth Factor beta | 1999 |
Effect of retinoids on AOM-induced colon cancer in rats: modulation of cell proliferation, apoptosis and aberrant crypt foci.
Topics: Adenocarcinoma; Adenoma; Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Body Weight; Carcinogens; Colon; Colonic Neoplasms; Drug Screening Assays, Antitumor; Fenretinide; Male; Precancerous Conditions; Rats; Rats, Inbred F344; Tretinoin | 1999 |
Prevention by aspirin and its combination with alpha-difluoromethylornithine of azoxymethane-induced tumors, aberrant crypt foci and prostaglandin E2 levels in rat colon.
Topics: Animals; Aspirin; Azoxymethane; Colon; Colonic Neoplasms; Dinoprostone; Dose-Response Relationship, Drug; Eflornithine; Male; Precancerous Conditions; Rats; Rats, Inbred F344 | 1999 |
Prevention of colonic preneoplastic lesions by the probiotic Lactobacillus acidophilus NCFMTM in F344 rats.
Topics: Animals; Azoxymethane; Choristoma; Colonic Neoplasms; Glucuronidase; Lactobacillus acidophilus; Male; Precancerous Conditions; Rats; Rats, Inbred F344; Risk Factors | 1999 |
Morphological and morphometric studies of the splenic antitumor immune response, elicited by liposome-covered soluble p53 kDa antigen, in chemically-induced rat colon cancer.
Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Liposomes; Male; Rats; Rats, Sprague-Dawley; Solubility; Spleen; Tumor Suppressor Protein p53; Vaccination | 1999 |
Chemoprevention of colonic aberrant crypt foci by an inducible nitric oxide synthase-selective inhibitor.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Carcinogens; Colonic Diseases; Colonic Neoplasms; Curcumin; Cyclooxygenase 2; Enzyme Inhibitors; Intestinal Mucosa; Isoenzymes; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Precancerous Conditions; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Inbred F344; Thiourea | 1999 |
Preliminary analysis of azoxymethane-induced colon tumorigenesis in mouse aggregation chimeras.
Topics: Animals; Azoxymethane; Biomarkers; Carcinogens; Cell Lineage; Chimera; Clone Cells; Colon; Colonic Neoplasms; DNA, Neoplasm; Drug Resistance; Genetic Predisposition to Disease; Genotype; Intestinal Mucosa; Mice; Mice, Inbred DBA; Mice, Inbred Strains; Microsatellite Repeats | 1999 |
Energy restriction modulates the development of advanced preneoplastic lesions depending on the level of fat in the diet.
Topics: Analysis of Variance; Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Corn Oil; Dietary Fats; Energy Intake; Male; Precancerous Conditions; Random Allocation; Rats; Rats, Inbred F344 | 1999 |
Quantitative assessment of azoxymethane-induced aberrant crypt foci in inbred mice.
Topics: Animals; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Epithelial Cells; Intestinal Mucosa; Mice; Mice, Inbred AKR; Mice, Inbred Strains; Precancerous Conditions | 1999 |
Tumor-enhancing effects of cholic acid are exerted on the early stages of colon carcinogenesis via induction of aberrant crypt foci with an enhanced growth phenotype.
Topics: Animals; Azoxymethane; Bile Acids and Salts; Carcinogens; Cholic Acid; Colon; Colonic Neoplasms; Drug Synergism; Male; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Time Factors | 1998 |
Inhibition of angiogenesis as a mechanism for inhibition by 1alpha-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 of colon carcinogenesis induced by azoxymethane in Wistar rats.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Azoxymethane; Calcitriol; Colonic Neoplasms; Dose-Response Relationship, Drug; Endothelial Growth Factors; Hydroxycholecalciferols; Immunohistochemistry; Incidence; Lymphokines; Male; Neovascularization, Pathologic; Rats; Rats, Wistar; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1999 |
Microsatellite instability is infrequent in azoxymethane-induced rat intestinal tumors: An assessment by capillary electrophoresis.
Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Electrophoresis, Capillary; Genes, p53; Male; Microsatellite Repeats; Polymerase Chain Reaction; Rats; Rats, Inbred F344 | 1999 |
Carcinogen and dietary lipid regulate ras expression and localization in rat colon without affecting farnesylation kinetics.
Topics: Alkyl and Aryl Transferases; Animals; Azoxymethane; Calcium-Calmodulin-Dependent Protein Kinases; Carcinogens; Colon; Colonic Neoplasms; Dietary Fats; Dietary Fiber; Enzyme Activation; Farnesyltranstransferase; Genes, ras; Intestinal Mucosa; Lipids; Male; Mutation; Protein Prenylation; Proto-Oncogene Proteins p21(ras); Rats; Rats, Sprague-Dawley | 1999 |
Polyethylene-glycol, a potent suppressor of azoxymethane-induced colonic aberrant crypt foci in rats.
Topics: Animals; Azoxymethane; Bile Acids and Salts; Carcinogens; Colon; Colonic Neoplasms; Diet; Feces; Female; Polyethylene Glycols; Precancerous Conditions; Rats; Rats, Inbred F344; Surface-Active Agents; Weight Gain | 1999 |
Effects of soy or rye supplementation of high-fat diets on colon tumour development in azoxymethane-treated rats.
Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Dietary Fats; Dietary Fiber; Estrogens, Non-Steroidal; Glycine max; Isoflavones; Male; Phytoestrogens; Plant Preparations; Rats; Rats, Inbred F344; Secale | 1999 |
Chemopreventive effect of N-(2-cyclohexyloxy-4-nitrophenyl)methane sulfonamide (NS-398), a selective cyclooxygenase-2 inhibitor, in rat colon carcinogenesis induced by azoxymethane.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoxymethane; Body Weight; Carcinogens; Chemoprevention; Colonic Neoplasms; Cyclooxygenase Inhibitors; Immunohistochemistry; Male; Nitrobenzenes; Organ Size; Proliferating Cell Nuclear Antigen; Rats; Rats, Inbred F344; Sulfonamides | 1999 |
Chemopreventive efficacy of sulindac sulfone against colon cancer depends on time of administration during carcinogenic process.
Topics: Adenocarcinoma; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colonic Neoplasms; Cyclooxygenase Inhibitors; Disease Progression; Dose-Response Relationship, Drug; Drug Administration Schedule; Male; Neoplasm Invasiveness; Rats; Rats, Inbred F344; Sulindac; Weight Gain | 1999 |
Chemopreventive effect of S-methylmethane thiosulfonate and sulindac administered together during the promotion/progression stages of colon carcinogenesis.
Topics: Adenocarcinoma; Adenoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Alkylating; Azoxymethane; Carcinogens; Colonic Neoplasms; Drug Screening Assays, Antitumor; Drug Therapy, Combination; Male; Methyl Methanesulfonate; Rats; Rats, Inbred F344; Sulindac | 1999 |
Feeding soybean resistant protein to rats raises fecal bile acid excretion but counteracts a deoxycholate-caused decrease in colonic aberrant crypt foci.
Topics: Animals; Azoxymethane; Bile Acids and Salts; Blood Proteins; Carcinogens; Chromatography, Thin Layer; Colonic Neoplasms; Deoxycholic Acid; Feces; Lipids; Male; Precancerous Conditions; Rats; Rats, Inbred F344; Soybean Proteins | 1999 |
Inhibitory effect of microfibril wheat bran on azoxymethane-induced colon carcinogenesis in CF1 mice.
Topics: Adenocarcinoma; Animals; Azoxymethane; Body Weight; Carcinogenicity Tests; Cellulose; Colonic Neoplasms; Dietary Fiber; Dietary Supplements; Fatty Acids, Volatile; Female; Gastrointestinal Contents; Mice; Mice, Inbred Strains | 1999 |
Effects of beta-glucuronidase-deficient and lycopene-producing Escherichia coli strains on formation of azoxymethane-induced aberrant crypt foci in the rat colon.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Beverages; Carcinogens; Carotenoids; Colon; Colonic Neoplasms; Dietary Fats; Escherichia coli; Feces; Glucuronidase; Intestinal Mucosa; Intestines; Lycopene; Male; Rats; Rats, Inbred F344; Rectum; Vegetables | 1999 |
Effects of roselle (Hibiscus sabdariffa Linn.), a Thai medicinal plant, on the mutagenicity of various known mutagens in Salmonella typhimurium and on formation of aberrant crypt foci induced by the colon carcinogens azoxymethane and 2-amino-1-methyl-6-ph
Topics: Animals; Anticarcinogenic Agents; Antimutagenic Agents; Azoxymethane; Chemoprevention; Colonic Neoplasms; DNA Methylation; Imidazoles; Liver Neoplasms; Malvaceae; Mutagenicity Tests; Mutagens; Neoplasm Staging; Plant Extracts; Plants, Medicinal; Precancerous Conditions; Rats; Rats, Inbred F344; Salmonella typhimurium; Thailand | 1999 |
Lovastatin augments sulindac-induced apoptosis in colon cancer cells and potentiates chemopreventive effects of sulindac.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Cyclooxygenase Inhibitors; Drug Synergism; Isoenzymes; Lovastatin; Male; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred F344; Sulindac; Tumor Cells, Cultured | 1999 |
Role of the prostaglandin E receptor subtype EP1 in colon carcinogenesis.
Topics: Animals; Azoxymethane; Bridged Bicyclo Compounds; Caproates; Colonic Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Precancerous Conditions; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype | 1999 |
Dietary prevention of azoxymethane-induced colon carcinogenesis with rice-germ in F344 rats.
Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Male; Oryza; Pilot Projects; Proliferating Cell Nuclear Antigen; Rats; Rats, Inbred F344 | 1999 |
Does senna extract promote growth of aberrant crypt foci and malignant tumors in rat colon?
Topics: Animals; Anthraquinones; Azoxymethane; Carcinogens; Cathartics; Colon; Colonic Neoplasms; Male; Rats; Rats, Wistar; Senna Extract; Sennosides | 1999 |
Inhibition of O(6)-methylguanine-DNA methyltransferase increases azoxymethane-induced colonic tumors in rats.
Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Enzyme Inhibitors; Genes, ras; Guanine; Kinetics; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Rats | 1999 |
Inhibition of azoxymethane-induced rat colon carcinogenesis by potassium hydrogen D-glucarate.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Cell Transformation, Neoplastic; Colonic Neoplasms; Glucaric Acid; Male; Rats; Rats, Inbred F344 | 2000 |
Granulocyte marker protein is increased in stools from rats with azoxymethane-induced colon cancer.
Topics: Animals; Azoxymethane; Biomarkers; Colonic Neoplasms; Diet; Dietary Fats; Dietary Fats, Unsaturated; Disease Models, Animal; Feces; Granulocytes; Intestine, Large; Male; Rats; Rats, Sprague-Dawley; Transferrin | 1999 |
Effect of olive oil on early and late events of colon carcinogenesis in rats: modulation of arachidonic acid metabolism and local prostaglandin E(2) synthesis.
Topics: Adenocarcinoma; Animals; Arachidonic Acid; Azoxymethane; Carcinogens; Chi-Square Distribution; Colon; Colonic Neoplasms; Dietary Fats, Unsaturated; Dinoprostone; Fatty Acids; Fish Oils; Intestinal Mucosa; Male; Olive Oil; Plant Oils; Random Allocation; Rats; Rats, Sprague-Dawley; Safflower Oil; Statistics, Nonparametric | 2000 |
Cyclooxygenase 2 expression is increased in the stroma of colon carcinomas from IL-10(-/-) mice.
Topics: Animals; Azoxymethane; Colon; Colonic Neoplasms; Cyclooxygenase 2; In Situ Hybridization; Inflammation; Interleukin-10; Intestinal Mucosa; Isoenzymes; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stromal Cells | 2000 |
Expression analysis of the group IIA secretory phospholipase A(2) in mice with differential susceptibility to azoxymethane-induced colon tumorigenesis.
Topics: Animals; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Colonic Polyps; Exons; Genetic Predisposition to Disease; Group II Phospholipases A2; Intestines; Mice; Mice, Inbred A; Mice, Inbred AKR; Mice, Inbred Strains; Phenotype; Phospholipases A; Reverse Transcriptase Polymerase Chain Reaction | 2000 |
Termination of piroxicam treatment and the occurrence of azoxymethane-induced colon cancer in rats.
Topics: Adenocarcinoma; Adenoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Azoxymethane; Body Weight; Carcinogenicity Tests; Carcinogens; Cell Division; Colonic Neoplasms; Disease Progression; Drug Administration Schedule; Intestinal Mucosa; Male; Piroxicam; Precancerous Conditions; Rats; Rats, Inbred F344 | 1999 |
Soybean curd refuse alleviates experimental tumorigenesis in rat colon.
Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Diet; Dietary Proteins; Glycine max; Male; Molecular Weight; Plant Extracts; Rats; Rats, Inbred F344 | 1999 |
Chemoprevention of colon cancer by specific cyclooxygenase-2 inhibitor, celecoxib, administered during different stages of carcinogenesis.
Topics: Administration, Oral; Animals; Anticarcinogenic Agents; Azoxymethane; Celecoxib; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Progression; Isoenzymes; Male; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Inbred F344; Sulfonamides; Time Factors | 2000 |
Suppression of azoxymethane-induced colonic aberrant crypt foci by a nitric oxide synthase inhibitor.
Topics: Animals; Anticarcinogenic Agents; Antigens, Nuclear; Azoxymethane; Body Weight; Carcinogens; Cell Division; Cell Nucleus; Colon; Colonic Neoplasms; Intestinal Mucosa; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nuclear Proteins; Precancerous Conditions; Rats; Rats, Inbred F344 | 2000 |
Colon cancer is induced by a single low dose of azoxymethane in fasted-refed rats.
Topics: Animals; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Fasting; Food; Male; Precancerous Conditions; Rats; Rats, Inbred F344; Rectal Neoplasms; Rectum | 1999 |
Mice overexpressing progastrin are predisposed for developing aberrant colonic crypt foci in response to AOM.
Topics: Animals; Azoxymethane; Bromodeoxyuridine; Carcinogens; Colon; Colonic Neoplasms; Disease Susceptibility; Gastrins; Humans; Mice; Mice, Inbred Strains; Mice, Transgenic; Precancerous Conditions; Protein Precursors | 2000 |
Lack of chemopreventive efficacy of DL-selenomethionine in colon carcinogenesis.
Topics: Adenocarcinoma; Adenoma; Animals; Azoxymethane; Colonic Neoplasms; Diet; Male; Rats; Rats, Inbred F344; Selenomethionine | 2000 |
Evaluation of flutamide genotoxicity in rats and in primary human hepatocytes.
Topics: Androgen Antagonists; Animals; Antineoplastic Agents, Hormonal; Azoxymethane; Colon; Colonic Neoplasms; Comet Assay; Diethylnitrosamine; DNA Damage; DNA Fragmentation; Female; Flutamide; Humans; Liver; Liver Neoplasms; Male; Micronucleus Tests; Middle Aged; Mutagens; Precancerous Conditions; Rats; Rats, Sprague-Dawley | 2000 |
Milk and dairy products in cancer prevention: focus on bovine lactoferrin.
Topics: Adenocarcinoma; Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Dairy Products; Diet; Dose-Response Relationship, Drug; Intestinal Polyps; Intestines; Lactoferrin; Male; Mice; Mice, Inbred C57BL; Milk; Rats; Rats, Inbred F344 | 2000 |
Obesity potentiates AOM-induced colon cancer.
Topics: Adenocarcinoma; Animals; Azoxymethane; Cell Transformation, Neoplastic; Colonic Neoplasms; Diet, Fat-Restricted; Intestinal Mucosa; Male; Obesity; Rats; Rats, Zucker; Risk Factors | 2000 |
ras p21 Isoprenylation inhibition induces flat colon tumors in Wistar rats.
Topics: Adenocarcinoma; Adenoma; Analysis of Variance; Animals; Antimetabolites; Apoptosis; Azoxymethane; Blotting, Western; Bromodeoxyuridine; Carcinogens; Colonic Neoplasms; Colonic Polyps; Genes, ras; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Incidence; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Oncogene Protein p21(ras); Point Mutation; Pravastatin; Prevalence; Protein Prenylation; Random Allocation; Rats; Rats, Wistar | 2000 |
Frequent mutations of the beta-catenin gene in mouse colon tumors induced by azoxymethane.
Topics: Animals; Azoxymethane; Base Sequence; beta Catenin; Carcinogens; Colonic Neoplasms; Cytoskeletal Proteins; DNA; Male; Mice; Mice, Inbred ICR; Mutation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single-Stranded Conformational; Rats; Trans-Activators | 2000 |
Inhibitory effect of a prostaglandin E receptor subtype EP(1) selective antagonist, ONO-8713, on development of azoxymethane-induced aberrant crypt foci in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Azoxymethane; Cinnamates; Colonic Neoplasms; Male; Mice; Mice, Inbred C57BL; Precancerous Conditions; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype | 2000 |
Chemoprevention of colon cancer carcinogenesis by balsalazide: inhibition of azoxymethane-induced aberrant crypt formation in the rat colon and intestinal tumor formation in the B6-Min/+ mouse.
Topics: Aminosalicylic Acids; Animals; Anti-Ulcer Agents; Anticarcinogenic Agents; Azoxymethane; Cell Division; Colonic Neoplasms; Genes, APC; Humans; Indomethacin; Intestinal Mucosa; Intestinal Neoplasms; Mesalamine; Mice; Mice, Mutant Strains; Phenylhydrazines; Prodrugs; Rats; Rats, Inbred F344; Tumor Cells, Cultured | 2000 |
Consistent and fast inhibition of colon carcinogenesis by polyethylene glycol in mice and rats given various carcinogens.
Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Dietary Fats; Dose-Response Relationship, Drug; Female; Male; Methylnitrosourea; Mice; Polyethylene Glycols; Precancerous Conditions; Quinolines; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Time Factors | 2000 |
Preventive effect of soybean resistant proteins against experimental tumorigenesis in rat colon.
Topics: Animals; Azoxymethane; Bile Acids and Salts; Carcinogens; Caseins; Cholesterol; Colonic Neoplasms; Deoxycholic Acid; Feces; Lipids; Male; Molecular Weight; Precancerous Conditions; Rats; Rats, Inbred F344; Soybean Proteins; Steroids | 2000 |
Altered expression of beta-catenin, inducible nitric oxide synthase and cyclooxygenase-2 in azoxymethane-induced rat colon carcinogenesis.
Topics: Adenocarcinoma; Adenoma; Animals; Azoxymethane; beta Catenin; Carcinogens; Colonic Neoplasms; Cyclooxygenase 2; Cytoskeletal Proteins; Gene Expression; Genes, ras; Hyperplasia; Isoenzymes; Male; Mutation; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Precancerous Conditions; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred F344; Subcellular Fractions; Trans-Activators | 2000 |
Progastrin expression predisposes mice to colon carcinomas and adenomas in response to a chemical carcinogen.
Topics: Adenoma; Amides; Animals; Azoxymethane; Carcinogens; Carcinoma; Colonic Neoplasms; Gastrins; Incidence; Mice; Mice, Transgenic; Neoplasms, Multiple Primary; Protein Precursors; Reference Values; Survival Analysis | 2000 |
Inhibition of azoxymethane-induced colon cancer by orange juice.
Topics: Animals; Antineoplastic Agents; Azoxymethane; Beverages; Carcinogens; Citrus; Colon; Colonic Neoplasms; Male; Phytotherapy; Rats; Rats, Inbred F344 | 2000 |
Suppressive effect of the herbal medicine Oren-gedoku-to on cyclooxygenase-2 activity and azoxymethane-induced aberrant crypt foci development in rats.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Carcinogens; Colonic Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drugs, Chinese Herbal; Isoenzymes; Male; Membrane Proteins; Plant Extracts; Precancerous Conditions; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred F344 | 2000 |
Modifying effects of ferulic acid on azoxymethane-induced colon carcinogenesis in F344 rats.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Coumaric Acids; Diet; Glutathione Transferase; Intestinal Mucosa; Liver; Male; NAD(P)H Dehydrogenase (Quinone); Precancerous Conditions; Rats; Rats, Inbred F344 | 2000 |
Frequent beta-catenin gene mutations and accumulations of the protein in the putative preneoplastic lesions lacking macroscopic aberrant crypt foci appearance, in rat colon carcinogenesis.
Topics: Amino Acid Substitution; Animals; Azoxymethane; beta Catenin; Cadherins; Colon; Colonic Neoplasms; Cytoskeletal Proteins; Intestinal Mucosa; Male; Point Mutation; Precancerous Conditions; Rats; Rats, Inbred F344; Trans-Activators | 2000 |
Morphodensitometric analysis of protein kinase C beta(II) expression in rat colon: modulation by diet and relation to in situ cell proliferation and apoptosis.
Topics: Animals; Apoptosis; Azoxymethane; Carcinogens; Cell Cycle; Cell Division; Cellulose; Colon; Colonic Neoplasms; Corn Oil; Diet; Fatty Acids, Omega-3; Immunohistochemistry; Isoenzymes; Male; Pectins; Precancerous Conditions; Protein Kinase C; Protein Kinase C beta; Rats; Rats, Sprague-Dawley; Subcellular Fractions | 2000 |
Phytic acid in wheat bran affects colon morphology, cell differentiation and apoptosis.
Topics: Animals; Apoptosis; Azoxymethane; Biomarkers, Tumor; Carcinogens; Cell Differentiation; Colon; Colonic Neoplasms; Dietary Fiber; Intestinal Mucosa; Lectins; Male; Mucins; Phytic Acid; Precancerous Conditions; Proliferating Cell Nuclear Antigen; Rats; Rats, Inbred F344 | 2000 |
Sequential and morphological analyses of aberrant crypt foci formation in mice of differing susceptibility to azoxymethane-induced colon carcinogenesis.
Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Disease Susceptibility; Drug Resistance; Mice; Mice, Inbred A; Mice, Inbred AKR; Precancerous Conditions; Species Specificity | 2000 |
Expression of transforming growth factor beta1 and its type II receptor in mouse colon tumors induced by azoxymethane.
Topics: Adenocarcinoma; Amino Acid Substitution; Animals; Azoxymethane; Carcinogens; Codon; Colonic Neoplasms; DNA Mutational Analysis; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Male; Mice; Neoplasm Proteins; Point Mutation; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2000 |
Gastrin-releasing peptide is a mitogen and a morphogen in murine colon cancer.
Topics: Adenocarcinoma; Animals; Apoptosis; Azoxymethane; Carcinogens; Cell Differentiation; Cell Division; Colonic Neoplasms; Epithelial Cells; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gastrin-Releasing Peptide; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogens; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Receptors, Bombesin | 2000 |
Differential expression of p16(INK4a) in azoxymethane-induced mouse colon tumorigenesis.
Topics: Adenocarcinoma; Adenoma; Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p16; Gene Deletion; Gene Expression Regulation, Neoplastic; Genes, p16; Genes, Retinoblastoma; Male; Mice; Mice, Inbred Strains; Neoplasm Proteins; Polymerase Chain Reaction; Precancerous Conditions; Retinoblastoma Protein; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm | 2000 |
Suppression of azoxymethane-induced colon carcinogenesis in male F344 rats by mandarin juices rich in beta-cryptoxanthin and hesperidin.
Topics: Adenocarcinoma; Adenoma; Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; beta Carotene; Beverages; Carcinogens; Citrus; Colonic Neoplasms; Cryptoxanthins; Cyclin D1; Hesperidin; Male; Proliferating Cell Nuclear Antigen; Rats; Rats, Inbred F344; Xanthophylls | 2000 |
Chemoprevention studies of the flavonoids quercetin and rutin in normal and azoxymethane-treated mouse colon.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Carcinogens; Cell Division; Colon; Colonic Neoplasms; Cyclin D1; Female; Intestinal Mucosa; Male; Mice; Precancerous Conditions; Quercetin; Rutin | 2000 |
Detection of somatic DNA alterations in azoxymethane-induced F344 rat colon tumors by random amplified polymorphic DNA analysis.
Topics: Adenocarcinoma; Adenoma; Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; DNA Damage; DNA Fingerprinting; DNA, Neoplasm; Genes, ras; Male; Microsatellite Repeats; Mutation; Precancerous Conditions; Random Amplified Polymorphic DNA Technique; Rats; Rats, Inbred F344 | 2000 |
Inhibitory effects of crude salts on the induction and development of colonic aberrant crypt foci in F-344 rats given azoxymethane.
Topics: Animals; Antineoplastic Agents; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Male; Precancerous Conditions; Rats; Rats, Inbred F344; Salts; Sodium Chloride, Dietary | 2000 |
Mutational and nonmutational activation of p21ras in rat colonic azoxymethane-induced tumors: effects on mitogen-activated protein kinase, cyclooxygenase-2, and cyclin D1.
Topics: Animals; Azoxymethane; beta Catenin; Carcinogens; Colonic Neoplasms; Cyclin D1; Cyclooxygenase 2; Cytoskeletal Proteins; Enzyme Activation; Genes, ras; Isoenzymes; Male; Mitogen-Activated Protein Kinase Kinases; Mutation; Polymorphism, Restriction Fragment Length; Prostaglandin-Endoperoxide Synthases; Proto-Oncogene Proteins p21(ras); Rats; Rats, Inbred F344; Trans-Activators | 2000 |
Preventive potential of wheat bran fractions against experimental colon carcinogenesis: implications for human colon cancer prevention.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Azoxymethane; Blotting, Western; Body Weight; Carcinogens; Colonic Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dietary Fiber; Humans; Isoenzymes; Male; Membrane Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phytic Acid; Plant Oils; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred F344 | 2000 |
Age-dependent induction of aberrant crypt foci in rat colon by 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine and azoxymethane.
Topics: Aging; Animals; Azoxymethane; Body Weight; Carcinogens; Choristoma; Colonic Neoplasms; Female; Imidazoles; Rats; Rats, Inbred F344 | 2000 |
K-ras point mutation is associated with enhancement by deoxycholic acid of colon carcinogenesis induced by azoxymethane, but not with its attenuation by all-trans-retinoic acid.
Topics: Administration, Oral; Animals; Anticarcinogenic Agents; Azoxymethane; Base Sequence; Carcinogens; Colon; Colonic Neoplasms; Deoxycholic Acid; Drug Synergism; Genes, ras; Intestinal Mucosa; Male; Mitotic Index; Point Mutation; Proto-Oncogene Proteins p21(ras); Rats; Rats, Wistar; Tretinoin | 2000 |
The effects of dietary selenomethionine on polyamines and azoxymethane-induced aberrant crypts.
Topics: Alanine Transaminase; Animals; Anticarcinogenic Agents; Azoxymethane; Biogenic Polyamines; Body Weight; Carcinogens; Colon; Colonic Neoplasms; Dietary Supplements; Dose-Response Relationship, Drug; Intestinal Mucosa; Liver; Male; Precancerous Conditions; Rats; Rats, Inbred F344; Selenium; Selenomethionine | 2000 |
Folate deficiency diminishes the occurrence of aberrant crypt foci in the rat colon but does not alter global DNA methylation status.
Topics: Animals; Azoxymethane; Carcinogens; Chromatography, High Pressure Liquid; Colon; Colonic Neoplasms; Data Interpretation, Statistical; Disease Models, Animal; DNA Methylation; Folic Acid; Folic Acid Deficiency; Homocysteine; Injections, Subcutaneous; Intestinal Mucosa; Liver; Male; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Risk Factors; Time Factors | 2000 |
Only fibres promoting a stable butyrate producing colonic ecosystem decrease the rate of aberrant crypt foci in rats.
Topics: Animals; Azoxymethane; Butyrates; Carcinogens; Colon; Colonic Neoplasms; Dietary Fiber; Fermentation; Intestinal Mucosa; Oligosaccharides; Rats; Rats, Inbred Strains; Starch | 2001 |
Folate deficiency reduces the development of colorectal cancer in rats.
Topics: Adenocarcinoma; Adenoma; Animals; Azoxymethane; Colonic Neoplasms; Colorectal Neoplasms; Folic Acid; Folic Acid Deficiency; Intestinal Neoplasms; Male; Rats; Rats, Sprague-Dawley | 2000 |
Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Body Weight; Brassica; Carcinogens; Colon; Colonic Neoplasms; Genotype; Glutathione Transferase; Humans; Intestinal Mucosa; Isothiocyanates; Male; Rats; Rats, Inbred F344; Sulfoxides; Thiocyanates; Vegetables | 2000 |
Carrageenan gel and aberrant crypt foci in the colon of conventional and human flora-associated rats.
Topics: Animals; Azoxymethane; Carcinogens; Carrageenan; Colon; Colonic Neoplasms; Dose-Response Relationship, Drug; Feces; Female; Gels; Germ-Free Life; Molecular Weight; Precancerous Conditions; Rats; Rats, Inbred F344 | 2000 |
Neonatal inoculation with the protein-bound polysaccharide PSK increases resistance of adult animals to challenge with syngeneic tumor cells and reduces azoxymethane-induced precancerous lesions in the colon.
Topics: Adenocarcinoma; Adjuvants, Immunologic; Age Factors; Animals; Animals, Newborn; Azoxymethane; Carcinogens; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Colon; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Neoplasm Transplantation; Precancerous Conditions; Proteoglycans; Rats; Rats, Inbred F344; Survival Analysis | 2000 |
Inhibition of azoxymethane-induced colon carcinogenesis in male F344 rats by the citrus limonoids obacunone and limonin.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Benzopyrans; Benzoxepins; Carcinogens; Colonic Neoplasms; Diet; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Eating; Limonins; Male; Pilot Projects; Precancerous Conditions; Rats; Rats, Inbred F344; Triterpenes | 2001 |
The inhibitory effects of mangiferin, a naturally occurring glucosylxanthone, in bowel carcinogenesis of male F344 rats.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Carcinogens; Cell Division; Colonic Neoplasms; Drug Screening Assays, Antitumor; Intestinal Mucosa; Male; Precancerous Conditions; Rats; Rats, Inbred F344; Xanthenes; Xanthones | 2001 |
Wheat aleurone flour increases cecal beta-glucuronidase activity and butyrate concentration and reduces colon adenoma burden in azoxymethane-treated rats.
Topics: Adenoma; Animals; Azoxymethane; Butyrates; Carcinogens; Cecum; Cellulose; Colonic Neoplasms; Dietary Fiber; Feces; Fermentation; Flour; Glucuronidase; Hydrogen-Ion Concentration; Male; Rats; Rats, Sprague-Dawley; Triticum | 2001 |
Prevention of colon carcinogenesis and carcinoma metastasis by orally administered bovine lactoferrin in animals.
Topics: Animals; Azoxymethane; Cattle; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Coculture Techniques; Colonic Neoplasms; G(M1) Ganglioside; Lactoferrin; Leukocytes; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Neoplasm Transplantation; Rats; Rats, Inbred F344; Tumor Cells, Cultured | 2000 |
Citrus limonoids obacunone and limonin inhibit azoxymethane-induced colon carcinogenesis in rats.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Benzopyrans; Benzoxepins; Carcinogens; Citrus; Colon; Colonic Neoplasms; Limonins; Male; Mitotic Index; Rats; Rats, Inbred F344; Triterpenes | 2000 |
Elevated protein kinase C betaII is an early promotive event in colon carcinogenesis.
Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Female; Genetic Predisposition to Disease; Immunohistochemistry; Isoenzymes; Mice; Mice, Inbred C57BL; Mice, Transgenic; Precancerous Conditions; Protein Kinase C; Protein Kinase C beta; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2001 |
Modulation of experimental colon tumorigenesis by types and amounts of dietary fatty acids.
Topics: Animals; Apoptosis; Arachidonic Acid; Azoxymethane; Body Weight; Carcinogens; Colonic Neoplasms; Corn Oil; Cyclooxygenase 1; Cyclooxygenase 2; Dietary Fats; Fatty Acids; Fish Oils; Intestinal Mucosa; Isoenzymes; Male; Membrane Proteins; Precancerous Conditions; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred F344 | 2001 |
Inhibitory effects of bitter melon (Momordica charantia Linn.) on bacterial mutagenesis and aberrant crypt focus formation in the rat colon.
Topics: Animals; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; DNA Adducts; Male; Mutagenesis; Mutagenicity Tests; Mutagens; Plant Extracts; Precancerous Conditions; Rats; Rats, Inbred F344; Rosales; Salmonella typhimurium | 2001 |
Ligands for peroxisome proliferator-activated receptors alpha and gamma inhibit chemically induced colitis and formation of aberrant crypt foci in rats.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Bezafibrate; Cell Division; Chromans; Colitis; Colonic Neoplasms; Dextran Sulfate; Growth Substances; Intestinal Mucosa; Ligands; Male; Mucins; Muscle Proteins; Neuropeptides; Nucleolus Organizer Region; Peptides; Precancerous Conditions; Proteins; Rats; Rats, Inbred F344; Receptors, Cytoplasmic and Nuclear; Silver Staining; Thiazoles; Thiazolidinediones; Transcription Factors; Trefoil Factor-2; Trefoil Factor-3; Troglitazone | 2001 |
Effects of indole-3-carbinol on immune responses, aberrant crypt foci, and colonic crypt cell proliferation in rats.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Biomarkers; Body Weight; Carcinogens; Cell Division; Colonic Neoplasms; Hypersensitivity, Delayed; Immunity; Immunoglobulin G; Immunohistochemistry; Indoles; Killer Cells, Natural; Male; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Spleen | 2001 |
Soy protein isolate consumption protects against azoxymethane-induced colon tumors in male rats.
Topics: Adenocarcinoma; Animals; Azoxymethane; Body Weight; Cell Division; Colonic Neoplasms; Food, Formulated; Male; Rats; Rats, Sprague-Dawley; Soybean Proteins | 2001 |
Chemopreventive effect of 2-(allylthio)pyrazine (2-AP) on rat colon carcinogenesis induced by azoxymethane (AOM).
Topics: Animals; Azoxymethane; Body Weight; Carcinogens; Colon; Colonic Neoplasms; Enzyme Inhibitors; Intestinal Mucosa; Male; Organ Size; Pyrazines; Rats; Rats, Inbred F344 | 2001 |
Chemoprevention of colon cancer by a glutathione conjugate of 1,4-phenylenebis(methylene)selenocyanate, a novel organoselenium compound with low toxicity.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Carcinogens; Colonic Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Dietary Fats; Drug Stability; Glutathione; Hydrogen-Ion Concentration; Isoenzymes; Male; Membrane Proteins; Organoselenium Compounds; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred F344 | 2001 |
Suppression of azoxymethane-induced preneoplastic lesions and inhibition of cyclooxygenase-2 activity in the colonic mucosa of rats drinking a crude green tea extract.
Topics: Animals; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Cyclooxygenase 2; Intestinal Mucosa; Isoenzymes; Male; Plant Extracts; Precancerous Conditions; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Tea | 2000 |
Endogenous N-nitroso compounds, and their precursors, present in bacon, do not initiate or promote aberrant crypt foci in the colon of rats.
Topics: Animals; Azoxymethane; Carcinogens; Cattle; Chickens; Colonic Neoplasms; Dietary Fats; Disease Models, Animal; Feces; Female; Food Handling; Meat; Nitroso Compounds; Random Allocation; Rats; Rats, Inbred F344; Risk Factors; Swine | 2000 |
Troglitazone, a ligand for peroxisome proliferator-activated receptor gamma, inhibits chemically-induced aberrant crypt foci in rats.
Topics: Animals; Antineoplastic Agents; Apoptosis; Azoxymethane; Biogenic Polyamines; Carcinogens; Chromans; Colitis; Colonic Neoplasms; Dextran Sulfate; Intestinal Mucosa; Ligands; Male; Ornithine Decarboxylase; Precancerous Conditions; Rats; Rats, Inbred F344; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2001 |
Dietary whey protein protects against azoxymethane-induced colon tumors in male rats.
Topics: Animals; Azoxymethane; Carcinogens; Caseins; Colonic Neoplasms; Diet; Disease Models, Animal; Female; Male; Milk Proteins; Pregnancy; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric | 2001 |
Non-involvement of the K-ras mutation in colon carcinogenesis promoted by dietary deoxycholate in azoxymethane-treated rats.
Topics: Animals; Azoxymethane; Carcinogens; Carcinoma; Colonic Neoplasms; Deoxycholic Acid; Diet; Genes, ras; Mutation; Polymorphism, Single-Stranded Conformational; Rats; Reverse Transcriptase Polymerase Chain Reaction | 2001 |
Suppression of occurrence and advancement of beta-catenin-accumulated crypts, possible premalignant lesions of colon cancer, by selective cyclooxygenase-2 inhibitor, celecoxib.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; beta Catenin; Celecoxib; Cell Division; Cell Nucleus; Colonic Neoplasms; Cyclooxygenase 2; Cytoskeletal Proteins; Enzyme Inhibitors; Immunohistochemistry; Isoenzymes; Male; Nucleolus Organizer Region; Precancerous Conditions; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Inbred F344; Sulfonamides; Time Factors; Trans-Activators | 2001 |
Qualitative and quantitative relationship between dysplastic aberrant crypt foci and tumorigenesis in the Min/+ mouse colon.
Topics: Adenoma; Adenomatous Polyposis Coli; Alleles; Animals; Azoxymethane; beta Catenin; Carcinogens; Cell Division; Cocarcinogenesis; Colonic Neoplasms; Cytoskeletal Proteins; Female; Genes, APC; Genetic Predisposition to Disease; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Precancerous Conditions; Trans-Activators | 2001 |
Vitamin B-6-supplemented diets compared with a low vitamin B-6 diet suppress azoxymethane-induced colon tumorigenesis in mice by reducing cell proliferation.
Topics: Animals; Apoptosis; Azoxymethane; Body Weight; Carcinogens; Cell Division; Colonic Neoplasms; Dietary Supplements; Dose-Response Relationship, Drug; Liver; Male; Mice; Mice, Inbred ICR; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-myc; Pyridoxine | 2001 |
High susceptibility of Scid mice to colon carcinogenesis induced by azoxymethane indicates a possible caretaker role for DNA-dependent protein kinase.
Topics: Adenocarcinoma; Animals; Azoxymethane; beta Catenin; Carcinogens; Cocarcinogenesis; Colonic Neoplasms; Cytoskeletal Proteins; DNA-Activated Protein Kinase; DNA-Binding Proteins; Female; Genetic Predisposition to Disease; Mice; Mice, SCID; Mutation; Precancerous Conditions; Protein Serine-Threonine Kinases; Trans-Activators | 2001 |
Aberrant transforming growth factor-beta signaling in azoxymethane-induced mouse colon tumors.
Topics: Adenoma; Animals; Azoxymethane; Carcinogens; Cell Cycle Proteins; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p15; DNA-Binding Proteins; Down-Regulation; Gene Expression Regulation, Neoplastic; Male; Mice; Mice, Inbred A; Mice, Inbred AKR; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-myc; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; RNA, Messenger; Signal Transduction; Smad3 Protein; Smad7 Protein; Trans-Activators; Transcription Factors; Transforming Growth Factor beta; Tumor Suppressor Proteins | 2001 |
Wheat germ extract inhibits experimental colon carcinogenesis in F-344 rats.
Topics: Animals; Azoxymethane; Body Weight; Carcinogens; Colon; Colonic Neoplasms; Kidney; Lectins; Liver; Lung; Male; Phytotherapy; Plant Extracts; Plant Lectins; Rats; Rats, Inbred F344; Triticum | 2001 |
Chemoprevention of azoxymethane-induced rat colon carcinogenesis by dietary capsaicin and rotenone.
Topics: Adenocarcinoma; Adenoma; Animals; Azoxymethane; Capsaicin; Carcinogens; Colonic Neoplasms; Diet; Dose-Response Relationship, Drug; Glutathione Transferase; Insecticides; Male; NAD(P)H Dehydrogenase (Quinone); Rats; Rats, Inbred F344; Rotenone | 2001 |
Effect of bisacodyl and cascara on growth of aberrant crypt foci and malignant tumors in the rat colon.
Topics: Adenocarcinoma; Adenoma; Animals; Azoxymethane; Bisacodyl; Carcinogens; Colon; Colonic Neoplasms; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Male; Precancerous Conditions; Rats; Rats, Wistar; Rhamnus | 2001 |
Chemoprevention of azoxymethane-induced rat aberrant crypt foci by dietary zerumbone isolated from Zingiber zerumbet.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Cell Division; Colon; Colonic Neoplasms; Cyclooxygenase 2; Diet; Dinoprostone; Dose-Response Relationship, Drug; Glutathione Transferase; Intestinal Mucosa; Isoenzymes; Liver; Male; NAD(P)H Dehydrogenase (Quinone); Nucleolus Organizer Region; Precancerous Conditions; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred F344; Sesquiterpenes; Silver Staining; Zingiberaceae | 2001 |
Anatomical site-specific response to DNA damage is related to later tumor development in the rat azoxymethane colon carcinogenesis model.
Topics: Adenocarcinoma; Animals; Apoptosis; Azoxymethane; Carcinogens; Colonic Neoplasms; DNA Adducts; DNA Damage; DNA Repair; DNA, Neoplasm; Immunoenzyme Techniques; Lipid Metabolism; Male; Methylation; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Sprague-Dawley | 2001 |
Down-regulation of PLK3 gene expression by types and amount of dietary fat in rat colon tumors.
Topics: Animals; Apoptosis; Azoxymethane; Blotting, Western; Carcinogens; Cell Cycle Proteins; Colonic Neoplasms; Corn Oil; Dietary Fats; DNA Primers; Down-Regulation; Fish Oils; Gene Expression; Intestinal Mucosa; Male; Protein Serine-Threonine Kinases; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2002 |
Short term infusion of glycine-extended gastrin(17) stimulates both proliferation and formation of aberrant crypt foci in rat colonic mucosa.
Topics: Animals; Azoxymethane; Carcinogens; Cell Division; Colon; Colonic Neoplasms; Gastrins; Glycine; Hormones; Male; Mucous Membrane; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Time Factors | 2001 |
Effect of grape seed proanthocyanidins on colon aberrant crypts and breast tumors in a rat dual-organ tumor model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anthocyanins; Azoxymethane; Carcinogens; Colonic Neoplasms; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Female; Glutathione Transferase; Liver; Mammary Neoplasms, Experimental; Ornithine Decarboxylase; Precancerous Conditions; Proanthocyanidins; Rats; Rats, Sprague-Dawley; Seeds; Vitis | 2001 |
Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis.
Topics: Animals; Azoxymethane; Carcinogens; Cell Division; Colon; Colonic Neoplasms; Dinoprostone; Female; Intestinal Polyps; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Precancerous Conditions; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; RNA, Messenger | 2002 |
Chemopreventive properties of a selective inducible nitric oxide synthase inhibitor in colon carcinogenesis, administered alone or in combination with celecoxib, a selective cyclooxygenase-2 inhibitor.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Body Weight; Carcinogens; Celecoxib; Colon; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Synergism; Enzyme Inhibitors; Homoarginine; Intestinal Mucosa; Isoenzymes; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Random Allocation; Rats; Rats, Inbred F344; Sulfonamides | 2002 |
Synergistic effects of (-)-epigallocatechin gallate with sulindac against colon carcinogenesis of rats treated with azoxymethane.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Azoxymethane; Carcinogens; Catechin; Choristoma; Colon; Colonic Neoplasms; Drug Synergism; In Situ Nick-End Labeling; Incidence; Male; Nucleolus Organizer Region; Precancerous Conditions; Rats; Rats, Inbred F344; Sulindac; Tea | 2002 |
Studies on cancer chemoprevention by traditional folk medicines XXV. Inhibitory effect of isoliquiritigenin on azoxymethane-induced murine colon aberrant crypt focus formation and carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Azoxymethane; Chalcone; Chalcones; Colonic Neoplasms; Male; Mice; Precancerous Conditions | 2002 |
Dietary conjugated linolenic acid inhibits azoxymethane-induced colonic aberrant crypt foci in rats.
Topics: Animals; Antioxidants; Apoptosis; Azoxymethane; Colonic Neoplasms; Dietary Fats, Unsaturated; Fatty Acids; Linoleic Acid; Male; Precancerous Conditions; Proliferating Cell Nuclear Antigen; Rats; Rats, Inbred F344; Receptors, Cytoplasmic and Nuclear; Transcription Factors | 2002 |
Development of a multi-organ rat model for evaluating chemopreventive agents: efficacy of indole-3-carbinol.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aflatoxin B1; Animals; Anticarcinogenic Agents; Azoxymethane; Body Weight; Carcinogens; Colonic Neoplasms; Disease Models, Animal; Female; Indoles; Liver; Liver Neoplasms; Mammary Neoplasms, Experimental; Mutagens; Neoplasms; Rats; Rats, Sprague-Dawley; Time Factors | 2002 |
Antimutagenicity of Murdannia loriformis in the Salmonella mutation assay and its inhibitory effects on azoxymethane-induced DNA methylation and aberrant crypt focus formation in male F344 rats.
Topics: Animals; Antimutagenic Agents; Antineoplastic Agents; Azoxymethane; Colon; Colonic Neoplasms; DNA Methylation; Guanine; Intestinal Mucosa; Magnoliopsida; Male; Mutagenicity Tests; Mutagens; Plant Extracts; Plants, Medicinal; Rats; Rats, Inbred F344; Salmonella typhimurium | 2002 |
Effect of ursodeoxycholic acid on azoxymethane-induced aberrant crypt foci formation in rat colon: in vitro potential role of intracellular Ca2+.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Bile Acids and Salts; Calcium; Calcium Signaling; Carcinogens; Colon; Colonic Neoplasms; Diet; Disease Models, Animal; Dose-Response Relationship, Drug; Intracellular Fluid; Male; Rats; Rats, Inbred F344; Tumor Cells, Cultured; Ursodeoxycholic Acid | 2002 |
Induction of apoptosis by sulindac in azoxymethane-induced possible colonic premalignant lesions in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Azoxymethane; beta Catenin; Carcinogens; Cell Division; Cell Nucleus; Colonic Neoplasms; Cytoskeletal Proteins; Diet; In Situ Nick-End Labeling; Incidence; Male; Nucleolus Organizer Region; Precancerous Conditions; Rats; Rats, Inbred F344; Silver; Sulindac; Trans-Activators | 2002 |
Effects of cyclooxygenase-2 inhibitor NS-398 on APC and c-myc expression in rat colon carcinogenesis induced by azoxymethane.
Topics: Animals; Azoxymethane; Carcinogens; Carcinoma; Colonic Neoplasms; Cyclooxygenase Inhibitors; Genes, APC; Genes, myc; Immunohistochemistry; Male; Models, Animal; Nitrobenzenes; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides | 2002 |
Effects of lyophilized black raspberries on azoxymethane-induced colon cancer and 8-hydroxy-2'-deoxyguanosine levels in the Fischer 344 rat.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adenocarcinoma; Adenoma; Animals; Anthocyanins; Anticarcinogenic Agents; Azoxymethane; Calcium; Cholesterol; Colonic Neoplasms; Coumaric Acids; Deoxyguanosine; Diet; Ellagic Acid; Freeze Drying; Fruit; Oxidative Stress; Rats; Rats, Inbred F344; Rosaceae; Sitosterols | 2001 |
Conditional loss of TGF-beta signalling leads to increased susceptibility to gastrointestinal carcinogenesis in mice.
Topics: Animals; Azoxymethane; Carcinogens; Carcinoma; Colonic Neoplasms; Disease Susceptibility; Gastritis; Helicobacter Infections; Helicobacter pylori; Mice; Mice, Transgenic; Receptors, Transforming Growth Factor beta; Signal Transduction; Stomach Neoplasms; Transforming Growth Factor beta | 2002 |
Dietary copper affects azoxymethane-induced intestinal tumor formation and protein kinase C isozyme protein and mRNA expression in colon of rats.
Topics: Animals; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Copper; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Isoenzymes; Male; Protein Kinase C; Random Allocation; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2002 |
Dietary vitamin B6 suppresses colon tumorigenesis, 8-hydroxyguanosine, 4-hydroxynonenal, and inducible nitric oxide synthase protein in azoxymethane-treated mice.
Topics: Adjuvants, Immunologic; Aldehydes; Analysis of Variance; Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Cross-Linking Reagents; Guanosine; Male; Mice; Mice, Inbred ICR; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Vitamin B 6 | 2002 |
Enhanced colon carcinogenesis induced by azoxymethane in min mice occurs via a mechanism independent of beta-catenin mutation.
Topics: Adenocarcinoma; Adenoma; Animals; Azoxymethane; beta Catenin; Carcinogens; Colonic Neoplasms; Cytoskeletal Proteins; DNA Primers; Male; Mice; Mice, Inbred C57BL; Mutagenesis; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Trans-Activators | 2002 |
A bitter diterpenoid furanolactone columbin from Calumbae Radix inhibits azoxymethane-induced rat colon carcinogenesis.
Topics: Animals; Antineoplastic Agents; Azoxymethane; Carcinogens; Cell Nucleus; Colon; Colonic Neoplasms; Diterpenes; Dose-Response Relationship, Drug; Lactones; Male; Mucous Membrane; Organ Size; Polyamines; Rats; Rats, Inbred F344; Terpenes; Time Factors | 2002 |
Conjugated linoleic acid does not inhibit development of aberrant crypt foci in colons of male Sprague-Dawley rats.
Topics: Animals; Azoxymethane; Colon; Colonic Neoplasms; Insulin; Linoleic Acid; Male; Precancerous Conditions; Rats; Rats, Sprague-Dawley | 2001 |
Effect of simple phenolic compounds on azoxymethane-induced aberrant crypt foci in rat colon.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Colon; Colonic Neoplasms; Coumaric Acids; Diet; Flavonoids; Hydroxybenzoates; Male; Parabens; Phenols; Precancerous Conditions; Rats; Rats, Inbred F344 | 2001 |
Role of the alternating reading frame (P19)-p53 pathway in an in vivo murine colon tumor model.
Topics: Adenocarcinoma; Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; DNA, Neoplasm; Gene Expression Regulation; Genes, p53; Male; Mice; Mice, Inbred A; Mice, Inbred AKR; Reading Frames; RNA, Messenger; Transcriptional Activation; Tumor Suppressor Protein p53; Up-Regulation | 2002 |
Dose response to a single injection of azoxymethane in rats. Induction of tumors in the gastrointestinal tract, auditory sebaceous glands, kidney, liver and preputial gland.
Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Animals; Azo Compounds; Azoxymethane; Carcinoma, Squamous Cell; Colon; Colonic Neoplasms; Duodenal Neoplasms; Duodenum; Ear Canal; Hyperplasia; Intestinal Polyps; Kidney; Kidney Neoplasms; Liver; Liver Cirrhosis; Liver Neoplasms; Male; Neoplasms; Rats; Rodent Diseases; Sebaceous Gland Neoplasms | 1975 |
Inhibits of of colon carcinogenesis.
Topics: Animals; Azoxymethane; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Disulfides; Disulfiram; Ditiocarb; Dose-Response Relationship, Drug; Female; Maneb; Mice; Thiocarbamates | 1977 |
Inhibitors for the mutagenicities of colon carcinogens, 1,2-dimethylhydrazine and azoxymethane, in the host-mediated assay.
Topics: Aminoacetonitrile; Animals; Azo Compounds; Azoxymethane; Carbon Disulfide; Colonic Neoplasms; Dimethylhydrazines; Disulfiram; Ditiocarb; Drug Evaluation, Preclinical; Male; Maneb; Methylhydrazines; Mice; Mutagens; Neoplasms, Experimental; Pyrazoles | 1979 |
Effect of dietary alfalfa, pectin, and wheat bran on azoxymethane-or methylnitrosourea-induced colon carcinogenesis in F344 rats.
Topics: Animals; Azoxymethane; Cellulose; Colonic Neoplasms; Dietary Fiber; Female; Medicago sativa; Methylnitrosourea; Neoplasms, Experimental; Pectins; Rats; Rats, Inbred F344; Triticum | 1979 |
Metabolism of the colon carcinogen methylazoxymethanol acetate.
Topics: Animals; Azo Compounds; Azoxymethane; Carcinogens; Colonic Neoplasms; Disulfiram; Drug Synergism; Male; Oxidoreductases; Pyrazoles; Rats | 1979 |
Enhanced colonic carcinogenesis with azoxymethane in rats after pancreaticobiliary diversion to mid small bowel.
Topics: Adenocarcinoma; Adenocarcinoma, Papillary; Ampulla of Vater; Animals; Azo Compounds; Azoxymethane; Bile; Bile Acids and Salts; Body Weight; Carcinoma, Squamous Cell; Colonic Neoplasms; DNA; Duodenal Neoplasms; Intestine, Small; Male; Neoplasms, Experimental; Pancreatic Juice; Rats; RNA | 1979 |
The cytochemical demonstration of beta-glucuronidase in colon neoplasms of rats exposed to azoxymethane.
Topics: Adenocarcinoma; Animals; Azo Compounds; Azoxymethane; Colon; Colonic Neoplasms; Glucuronidase; Intestinal Mucosa; Intestinal Polyps; Lymphatic Metastasis; Male; Neoplasms, Experimental; Rats | 1978 |
Promotion of azoxymethane-induced colonic neoplasia by resection of the proximal small bowel.
Topics: Adaptation, Physiological; Animals; Azo Compounds; Azoxymethane; Colonic Neoplasms; DNA; Hyperplasia; Ileum; Intestinal Mucosa; Intestine, Small; Jejunum; Male; Neoplasm Metastasis; Neoplasms, Experimental; Rats; RNA | 1978 |
Effect of dietary undegraded carrageenan on colon carcinogenesis in F344 rats treated with azoxymethane or methylnitrosourea.
Topics: Animals; Azo Compounds; Azoxymethane; Carrageenan; Cellulose; Colonic Neoplasms; Dietary Fiber; Female; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Rats, Inbred F344; Rectal Neoplasms | 1978 |
Experimental tumors in digestive organs.
Topics: Animals; Azoxymethane; Benz(a)Anthracenes; Colonic Neoplasms; Cricetinae; Dogs; Duodenal Neoplasms; Esophageal Neoplasms; Gastrointestinal Neoplasms; Guinea Pigs; Methylnitronitrosoguanidine; Mice; Neoplasms, Experimental; Nitrites; Nitrosamines; Nitrosoguanidines; Pancreatic Neoplasms; Rabbits; Rats; Stomach Neoplasms | 1976 |
Immunosuppression in primary liver and colon tumor induction with N-hydroxy-N-2-fluorenylacetamide and azoxymethane.
Topics: 2-Acetylaminofluorene; Animals; Antilymphocyte Serum; Azoxymethane; Colonic Neoplasms; Hemangiosarcoma; Immunosuppression Therapy; Liver Neoplasms; Male; Neoplasms, Experimental; Rats; Sarcoma, Experimental; Time Factors | 1975 |
Investigations into the metabolism and mode of action of the colon carcinogen 1, 2-dimethylhydrazine.
Topics: Animals; Azo Compounds; Azoxymethane; Chromatography, Gel; Chromatography, Thin Layer; Colonic Neoplasms; Dimethylhydrazines; Hydrazines; Methane; Methylazoxymethanol Acetate; Neoplasms, Experimental | 1975 |
Colon carcinogenesis in germ-free rats with intrarectal 1,2-dimethylhydrazine and subcutaneous azoxymethane.
Topics: Animals; Azo Compounds; Azoxymethane; Colonic Neoplasms; Dimethylhydrazines; Female; Germ-Free Life; Hydrazines; Injections, Subcutaneous; Intestines; Rats | 1976 |
The effect of high-risk and low-risk diets on aberrant crypt and colonic tumor formation in Fischer-344 rats.
Topics: Animals; Azoxymethane; Body Weight; Calcium, Dietary; Colon; Colonic Neoplasms; Dietary Fats; Dietary Fiber; Male; Precancerous Conditions; Rats; Rats, Inbred F344 | 1992 |
Attenuation by the GABA receptor agonist baclofen of experimental carcinogenesis in rat colon by azoxymethane.
Topics: Adenocarcinoma; Adenoma; Animals; Azoxymethane; Baclofen; Cell Division; Colon; Colonic Neoplasms; Hyperplasia; Intestinal Mucosa; Male; Muscimol; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1992 |
Association between permeability of the colonic wall and azoxymethane induced cancer of the colon in rats.
Topics: Animals; Azoxymethane; Cell Membrane Permeability; Colon; Colonic Neoplasms; Fluorescein; Fluoresceins; Incidence; Male; Rats; Time Factors | 1992 |
Aberrant crypts correlate with tumor incidence in F344 rats treated with azoxymethane and phytate.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Phytic Acid; Precancerous Conditions; Rats; Rats, Inbred F344 | 1992 |
Evidence for a ras gene mutation in azoxymethane-induced colonic aberrant crypts in Sprague-Dawley rats: earliest recognizable precursor lesions of experimental colon cancer.
Topics: Adenocarcinoma; Animals; Azoxymethane; Base Sequence; Colonic Neoplasms; DNA, Single-Stranded; Genes, ras; Immunohistochemistry; Male; Molecular Sequence Data; Mutation; Polymerase Chain Reaction; Precancerous Conditions; Proto-Oncogene Proteins p21(ras); Rats; Rats, Sprague-Dawley | 1992 |
Effect of dietary oxidized cholesterol on azoxymethane-induced colonic preneoplasia in mice.
Topics: Analysis of Variance; Animals; Azoxymethane; Cholesterol, Dietary; Colonic Neoplasms; Female; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Oxidation-Reduction; Precancerous Conditions; Sterols | 1992 |
Aberrant crypt foci and microadenoma as markers for colon cancer.
Topics: Adenoma; Animals; Azoxymethane; Cocarcinogenesis; Colonic Neoplasms; Diet; Hot Temperature; Mice; Precancerous Conditions; Random Allocation; Rats; Rats, Inbred F344 | 1992 |
Enhancement by bombesin of colon carcinogenesis and metastasis induced by azoxymethane in Wistar rats.
Topics: Adenocarcinoma; Animals; Azoxymethane; Bombesin; Colon; Colonic Neoplasms; Gastrins; Male; Neoplasm Metastasis; Norepinephrine; Rats; Rats, Inbred Strains | 1992 |
Enhancement by thyroxine of experimental carcinogenesis induced in rat colon by azoxymethane.
Topics: Adenocarcinoma; Adenoma; Analysis of Variance; Animals; Azoxymethane; Body Weight; Carcinogens; Colonic Neoplasms; Drug Synergism; Intestinal Mucosa; Male; Mitotic Index; Neoplasm Metastasis; Probability; Rats; Rats, Inbred Strains; Thyroxine; Triiodothyronine | 1992 |
Dietary cholesterol enhances preneoplastic aberrant crypt formation and alters cell proliferation in the murine colon treated with azoxymethane.
Topics: Analysis of Variance; Animals; Azoxymethane; Cell Count; Cell Division; Cholesterol, Dietary; Colonic Neoplasms; Disease Susceptibility; Female; Intestinal Mucosa; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Precancerous Conditions; Random Allocation | 1992 |
Inhibition of colon carcinogenesis by prostaglandin synthesis inhibitors and related compounds.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Glycyrrhetinic Acid; Ibuprofen; Ketoprofen; Male; Piroxicam; Random Allocation; Rats; Rats, Inbred F344 | 1992 |
Effect of dietary benzylselenocyanate on azoxymethane-induced colon carcinogenesis in male F344 rats.
Topics: Analysis of Variance; Animals; Azoxymethane; Chi-Square Distribution; Colonic Neoplasms; Cyanates; Dietary Fats; Male; Organoselenium Compounds; Rats; Rats, Inbred F344; Selenium; Sodium Selenite; Thiocyanates | 1991 |
Inhibition by the dopamine antagonist haloperidol of experimental carcinogenesis induced by azoxymethane in rat colon.
Topics: Adenocarcinoma; Animals; Azoxymethane; Body Weight; Bromocriptine; Colonic Neoplasms; Cyclic AMP; DNA; Dopamine Antagonists; Energy Intake; Haloperidol; Male; Mitotic Index; Rats; Rats, Inbred Strains | 1991 |
Enhanced induction of colon carcinogenesis by azoxymethane in Wistar rats fed a low-protein diet.
Topics: Adenocarcinoma; Adenoma; Animals; Azoxymethane; Cell Division; Colon; Colonic Neoplasms; Dietary Proteins; Gastrins; Intestinal Mucosa; Male; Norepinephrine; Rats; Rats, Inbred Strains | 1992 |
Inhibition of azoxymethane-induced experimental colon carcinogenesis in Wistar rats by 6-hydroxydopamine.
Topics: Adenocarcinoma; Adenoma; Animals; Azoxymethane; Carcinoma in Situ; Colon; Colonic Neoplasms; Intestinal Mucosa; Male; Norepinephrine; Oxidopamine; Rats; Rats, Inbred Strains | 1992 |
Hepatic pathology of the colon carcinogen, azoxymethane, in Hanford-Moore miniature pigs.
Topics: Animals; Azoxymethane; Chemical and Drug Induced Liver Injury; Colonic Neoplasms; Disease Models, Animal; Female; Hemorrhage; Liver; Male; Necrosis; Rodentia; Species Specificity; Swine; Swine, Miniature | 1991 |
Inhibition of azoxymethane-induced colon carcinogenesis in rat by green tea polyphenol fraction.
Topics: Animals; Azoxymethane; Body Weight; Catechin; Colonic Neoplasms; Flavonoids; Male; Phenols; Plant Extracts; Polymers; Rats; Rats, Inbred F344; Tea; Time Factors | 1991 |
Effect of diets high in omega-3 and omega-6 fatty acids on initiation and postinitiation stages of colon carcinogenesis.
Topics: Adenocarcinoma; Animals; Azoxymethane; Colonic Neoplasms; Corn Oil; Dietary Fats; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Fatty Acids, Unsaturated; Fish Oils; Male; Rats; Rats, Inbred F344 | 1991 |
Evaluation of dietary dehydroepiandrosterone for chemoprotection against tumorigenesis in premalignant colonic epithelium of male F344 rats.
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Agents; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Dehydroepiandrosterone; Diet; Dimethylhydrazines; Epithelium; Male; Muscle, Smooth; Precancerous Conditions; Rats; Rats, Inbred F344; Reference Values | 1991 |
Prevention by chemopreventive agents of azoxymethane-induced foci of aberrant crypts in rat colon.
Topics: Acetylcysteine; Allyl Compounds; Animals; Anticarcinogenic Agents; Azoxymethane; Colon; Colonic Neoplasms; Dehydroepiandrosterone; Eflornithine; Ellagic Acid; Isothiocyanates; Male; Precancerous Conditions; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Sulfides; Thiazoles; Thiazolidines; Thiocyanates | 1991 |
Experimental model of colon cancer: recurrences after surgery alone or associated with intraperitoneal 5-fluorouracil chemotherapy.
Topics: Adenocarcinoma; Animals; Azoxymethane; Colectomy; Colonic Neoplasms; Combined Modality Therapy; Disease Models, Animal; Fluorouracil; Injections, Intraperitoneal; Liver Neoplasms; Male; Neoplasm Recurrence, Local; Prognosis; Random Allocation; Rats | 1991 |
Enhancement by methionine enkephalin of colon carcinogenesis induced by azoxymethane.
Topics: Adenocarcinoma; Animals; Azoxymethane; Colon; Colonic Neoplasms; Drug Administration Schedule; Drug Synergism; Enkephalin, Methionine; Male; Naloxone; Rats; Rats, Inbred Strains | 1991 |
The effects of intracolonic EGF on mucosal growth and experimental carcinogenesis.
Topics: Animals; Azoxymethane; Colon; Colonic Neoplasms; Epidermal Growth Factor; ErbB Receptors; Intestinal Mucosa; Iodine Radioisotopes; Male; Rats; Rats, Inbred Strains | 1991 |
Inhibition by putrescine of experimental carcinogenesis in rat colon induced by azoxymethane.
Topics: Adenocarcinoma; Adenoma; Animals; Azoxymethane; Body Weight; Carcinoma in Situ; Cell Transformation, Neoplastic; Colonic Neoplasms; Male; Ornithine Decarboxylase; Putrescine; Rats; Rats, Inbred Strains | 1991 |
Effect of oltipraz [5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione] on azoxymethane-induced biochemical changes related to early colon carcinogenesis in male F344 rats.
Topics: Animals; Antineoplastic Agents; Azoxymethane; Body Weight; Colon; Colonic Neoplasms; Cytosol; DNA; Glutathione Transferase; Intestinal Mucosa; Liver; Male; Methylation; Ornithine Decarboxylase; Protein-Tyrosine Kinases; Pyrazines; Rats; Rats, Inbred F344; Reference Values; Thiones; Thiophenes | 1991 |
Mechanism of benzylselenocyanate inhibition of azoxymethane-induced colon carcinogenesis in F344 rats.
Topics: Animals; Azoxymethane; Body Weight; Colonic Neoplasms; Cyanates; Cytochrome P-450 Enzyme System; DNA; Drug Screening Assays, Antitumor; Guanine; Male; Methylation; Methylazoxymethanol Acetate; Microsomes, Liver; Organoselenium Compounds; Rats; Rats, Inbred F344; Selenium | 1991 |
Effect of disulfiram on 1,2-dimethylhydrazine- and azoxymethane-induced aberrant crypt foci.
Topics: 1,2-Dimethylhydrazine; Animals; Azoxymethane; Body Weight; Colonic Neoplasms; Dimethylhydrazines; Disulfiram; Female; Intestinal Mucosa; Mice; Precancerous Conditions | 1991 |
Effects of androgen manipulations on chemically induced colonic tumours and on macroscopically normal colonic mucosa in male Sprague-Dawley rats.
Topics: Adenocarcinoma; Animals; Azoxymethane; Colonic Neoplasms; Cyproterone; Cyproterone Acetate; Drug Synergism; Intestinal Mucosa; Male; Mitotic Index; Orchiectomy; Rats; Rats, Inbred Strains; Testosterone | 1990 |
Enhancement by neurotensin of experimental carcinogenesis induced in rat colon by azoxymethane.
Topics: Adenocarcinoma; Adenoma; Animals; Azoxymethane; Body Weight; Colonic Neoplasms; Drug Synergism; Gastrins; Male; Neurotensin; Rats; Rats, Inbred Strains | 1990 |
Promotion of colonic microadenoma growth in mice and rats fed cooked sugar or cooked casein and fat.
Topics: Adenoma; Animals; Azoxymethane; Body Weight; Caseins; Colonic Neoplasms; Dietary Carbohydrates; Dietary Fats; Female; Hot Temperature; Mice; Rats; Rats, Inbred F344; Time Factors | 1990 |
Methane excretion and experimental colonic carcinogenesis.
Topics: Adenocarcinoma; Animals; Azoxymethane; Colonic Neoplasms; Male; Methane; Rats; Rats, Inbred F344; Time Factors | 1990 |
Enhancement of azoxymethane-induced colon carcinogenesis in spontaneously hypertensive rats.
Topics: Adenocarcinoma; Adenoma; Animals; Azoxymethane; Carcinoma in Situ; Colon; Colonic Neoplasms; Intestinal Mucosa; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Species Specificity | 1990 |
Dietary butyrate (tributyrin) does not enhance AOM-induced colon tumorigenesis.
Topics: Animals; Azo Compounds; Azoxymethane; Body Weight; Cocarcinogenesis; Colonic Neoplasms; Diet; Drug Evaluation, Preclinical; Fatty Acids; Feces; Female; Mice; Precancerous Conditions; Triglycerides | 1990 |
Effect of defunction on cytokinetics and cancer at colonic suture lines.
Topics: Adaptation, Physiological; Animals; Azoxymethane; Body Weight; Colon; Colonic Neoplasms; Kinetics; Male; Organ Size; Rats; Rats, Inbred Strains; Sutures | 1990 |
Experimental colonic carcinogenesis after gastric surgery.
Topics: Adaptation, Physiological; Animals; Azoxymethane; Bile Acids and Salts; Colon; Colonic Neoplasms; Feces; Gastrectomy; Intestinal Mucosa; Male; Postoperative Period; Pylorus; Rats; Rats, Inbred Strains; Steroids; Stomach; Vagotomy | 1990 |
Effect of different levels of calorie restriction on azoxymethane-induced colon carcinogenesis in male F344 rats.
Topics: Animals; Azoxymethane; Colon; Colonic Neoplasms; Dietary Fats; Energy Intake; Intestinal Mucosa; Male; Ornithine Decarboxylase; Protein-Tyrosine Kinases; Rats; Rats, Inbred F344 | 1990 |
Inhibition of the promotional phase of azoxymethane-induced colon carcinogenesis in the F344 rat by calcium lactate: effect of simulating two human nutrient density levels.
Topics: Animals; Azo Compounds; Azoxymethane; Calcium; Calcium, Dietary; Colonic Neoplasms; Dietary Fats; Disease Models, Animal; Fatty Acids; Feces; Female; Hydrogen-Ion Concentration; Lactates; Lactic Acid; Phosphorus; Rats; Rats, Inbred F344 | 1990 |
Effects of timing of administration and dose of difluoromethylornithine on rat colonic carcinogenesis.
Topics: Animals; Azoxymethane; Colon; Colonic Neoplasms; Eflornithine; Enzyme Induction; Intestinal Mucosa; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Rats; Rats, Inbred F344 | 1989 |
Distribution of the c-myc oncoprotein in normal and neoplastic tissues of the rat colon.
Topics: Animals; Azoxymethane; Colon; Colonic Neoplasms; Immunohistochemistry; Male; Proto-Oncogene Proteins c-myc; Rats; Rats, Inbred F344 | 1988 |
Tissue norepinephrine depletion as a mechanism for cysteamine inhibition of colon carcinogenesis induced by azoxymethane in Wistar rats.
Topics: Adenocarcinoma; Adenoma; Animals; Azoxymethane; Carcinoma; Cell Division; Colon; Colonic Neoplasms; Cysteamine; Gastrins; Male; Norepinephrine; Rats; Rats, Inbred Strains | 1989 |
Effects of the experimental chemopreventative agent, glucarate, on intestinal carcinogenesis in rats.
Topics: Animals; Azoxymethane; Body Weight; Colonic Neoplasms; Diet; Female; Glucaric Acid; Intestinal Neoplasms; Neoplasm Metastasis; Rats; Rats, Inbred F344; Sugar Acids | 1989 |
An investigation of colon cancer associated with urinary diversion.
Topics: Adenocarcinoma; Adenoma; Anastomosis, Surgical; Animals; Azoxymethane; Colon; Colonic Neoplasms; Male; Mesocolon; Rats; Rats, Inbred F344; Urinary Bladder; Urinary Diversion | 1989 |
[Effects of indomethacin and prostaglandin E2 administered intrarectally on colon carcinogenesis induced by azoxymethane (AOM) in rats].
Topics: Administration, Rectal; Animals; Azoxymethane; Colon; Colonic Neoplasms; Dinoprostone; Indomethacin; Intestinal Mucosa; Killer Cells, Natural; Male; Rats; Rats, Inbred Strains | 1989 |
Dietary manipulation during experimental colorectal carcinogenesis: a morphological study in the rat.
Topics: Animals; Azoxymethane; Colon; Colonic Neoplasms; Dietary Fats; Dietary Fiber; Intestinal Mucosa; Male; Precancerous Conditions; Rats | 1987 |
Suppression of large intestinal cancer in F344 rats by inositol hexaphosphate.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Electron Spin Resonance Spectroscopy; Free Radicals; Hydroxides; Hydroxyl Radical; Male; Phytic Acid; Rats; Rats, Inbred F344 | 1988 |
Effect of dietary eicosapentaenoic acid on azoxymethane-induced colon carcinogenesis in rats.
Topics: Animals; Azoxymethane; Bile Acids and Salts; Colon; Colonic Neoplasms; Dietary Fats, Unsaturated; Dinoprostone; Eicosapentaenoic Acid; Fatty Acids; Male; Prostaglandins E; Rats | 1988 |
Inositol hexaphosphate inhibits large intestinal cancer in F344 rats 5 months after induction by azoxymethane.
Topics: Animals; Azo Compounds; Azoxymethane; Colonic Neoplasms; Phytic Acid; Rats; Rats, Inbred F344; Rectal Neoplasms | 1989 |
Androgen receptors in experimentally induced colon carcinogenesis.
Topics: Animals; Azoxymethane; Binding Sites; Body Weight; Colon; Colonic Neoplasms; Cyproterone; Cyproterone Acetate; Cytosol; Estrenes; Kinetics; Male; Metribolone; Orchiectomy; Rats; Rats, Inbred Strains; Receptors, Androgen; Rectal Neoplasms; Testosterone | 1986 |
Inhibitory effect of dietary p-methoxybenzeneselenol on azoxymethane-induced colon and kidney carcinogenesis in female F344 rats.
Topics: Adenocarcinoma; Adenoma; Animals; Anisoles; Azoxymethane; Colonic Neoplasms; Diet; Female; Kidney Neoplasms; Neoplasms, Multiple Primary; Organoselenium Compounds; Rats; Rats, Inbred F344; Selenium; Wilms Tumor | 1985 |
Experimental colorectal cancer: the relationship of diet and faecal bile acid concentration to tumour induction.
Topics: Animals; Azoxymethane; Bile Acids and Salts; Colonic Neoplasms; Diet; Dietary Fats; Dietary Fiber; Disease Models, Animal; Feces; Male; Rats; Rats, Inbred Strains; Rectal Neoplasms | 1986 |
Morphological and cell kinetic effects of dietary manipulation during colorectal carcinogenesis.
Topics: Animals; Azoxymethane; Cell Division; Cocarcinogenesis; Colon; Colonic Neoplasms; Dietary Fats; Dietary Fiber; Feces; Male; Mice; Mice, Inbred Strains; Microscopy, Electron, Scanning; Rectal Neoplasms | 1987 |
Effects of timing and quantity of chronic dietary ethanol consumption on azoxymethane-induced colonic carcinogenesis and azoxymethane metabolism in Fischer 344 rats.
Topics: Animals; Azo Compounds; Azoxymethane; Carbon Dioxide; Carbon Radioisotopes; Colonic Neoplasms; DNA; Dose-Response Relationship, Drug; Energy Intake; Ethanol; Male; Rats; Rats, Inbred F344; Time Factors | 1987 |
Alpha-difluoromethylornithine-induced inhibition of growth of autochthonous experimental colonic tumors produced by azoxymethane in male F344 rats.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Eflornithine; Male; Ornithine Decarboxylase; Rats; Rats, Inbred F344 | 1988 |
Aberrant crypts: potential preneoplastic lesions in the murine colon.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Dietary Fats; Dose-Response Relationship, Drug; Mice; Mice, Inbred C57BL; Precancerous Conditions; Species Specificity | 1988 |
Effect of different levels of omega-3 and omega-6 fatty acids on azoxymethane-induced colon carcinogenesis in F344 rats.
Topics: Animals; Azoxymethane; Colon; Colonic Neoplasms; Corn Oil; Fatty Acids, Unsaturated; Fish Oils; Intestinal Mucosa; Male; Ornithine Decarboxylase; Plant Oils; Rats; Rats, Inbred F344 | 1988 |
Effect of voluntary exercise on azoxymethane-induced colon carcinogenesis in male F344 rats.
Topics: Animals; Azo Compounds; Azoxymethane; Body Weight; Colonic Neoplasms; Eating; Male; Physical Conditioning, Animal; Rats; Rats, Inbred F344 | 1988 |
Inhibition by isoproterenol and neostigmine of experimental carcinogenesis in rat colon by azoxymethane.
Topics: Adenocarcinoma; Animals; Autonomic Nervous System; Azoxymethane; Colonic Neoplasms; Intestinal Mucosa; Isoproterenol; Male; Neostigmine; Rats; Rats, Inbred Strains | 1988 |
Effect of dietary excess of inorganic selenium during initiation and postinitiation phases of colon carcinogenesis in F344 rats.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Drug Administration Schedule; Duodenal Neoplasms; Glutathione Peroxidase; Male; Rats; Rats, Inbred F344; Selenium | 1988 |
The effects of a "low-risk" diet on tumor incidence in chemically induced colon cancer in rats.
Topics: Adenocarcinoma; Animals; Azoxymethane; Colonic Neoplasms; Food, Formulated; Rats; Rats, Inbred F344; Risk Factors | 1988 |
Inhibition by dietary ethanol of experimental colonic carcinogenesis induced by high-dose azoxymethane in F344 rats.
Topics: Alkylation; Animals; Azo Compounds; Azoxymethane; Colonic Neoplasms; Diet; DNA; Ethanol; Guanine; Male; Rats; Rats, Inbred F344 | 1988 |
Experimental colonic carcinogenesis: changes in faecal bile acids after promotion of intestinal tumours by small bowel resection in the rat.
Topics: Animals; Azoxymethane; Bile Acids and Salts; Cell Division; Cocarcinogenesis; Colonic Neoplasms; Duodenal Neoplasms; Feces; Intestine, Small; Intestines; Male; Rats; Rats, Inbred Strains | 1988 |
Changes in expression of oncogenes and endogenous retroviral-like sequences during colon carcinogenesis.
Topics: Animals; Azoxymethane; Body Weight; Colonic Neoplasms; Dietary Fats; Gene Expression Regulation; Intestinal Mucosa; Male; Oncogenes; Rats; Rats, Inbred F344; Retroviridae | 1988 |
Interactions of selenium deficiency, vitamin E, polyunsaturated fat, and saturated fat on azoxymethane-induced colon carcinogenesis in male F344 rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adenoma; Animals; Azoxymethane; Colonic Neoplasms; Dietary Fats; Dimethylhydrazines; Fatty Acids, Unsaturated; Intestinal Neoplasms; Male; Rats; Rats, Inbred F344; Selenium; Vitamin E | 1986 |
Effect of different levels of dietary corn oil and lard during the initiation phase of colon carcinogenesis in F344 rats.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Azoxymethane; Bile Acids and Salts; Body Weight; Colon; Colonic Neoplasms; Corn Oil; Dietary Fats; Dimethylhydrazines; Eating; Male; Oils; Ornithine Decarboxylase; Rats; Rats, Inbred F344 | 1986 |
Effect of hypothermia on intestinal adaptation and carcinogenesis in the rat.
Topics: Adaptation, Biological; Animals; Azoxymethane; Body Weight; Cell Count; Cold Temperature; Colonic Neoplasms; Eating; Hyperplasia; Intestinal Mucosa; Intestinal Neoplasms; Intestine, Small; Male; Rats; Rats, Inbred Strains; Rectal Neoplasms | 1987 |
Surgical prophylaxis against large bowel tumors in an animal model.
Topics: Animals; Azoxymethane; Colectomy; Colonic Neoplasms; Male; Rats; Rectal Neoplasms; Rectum | 1987 |
Enhancement by vasoactive intestinal peptide of experimental carcinogenesis induced by azoxymethane in rat colon.
Topics: Animals; Azoxymethane; Cell Division; Colon; Colonic Neoplasms; Intestinal Mucosa; Male; Rats; Rats, Inbred Strains; Vasoactive Intestinal Peptide | 1987 |
Dose-related inhibition of colon carcinogenesis by dietary piroxicam, a nonsteroidal antiinflammatory drug, during different stages of rat colon tumor development.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoxymethane; Colonic Neoplasms; Diet; Ear Canal; Ear Neoplasms; Intestinal Neoplasms; Intestine, Small; Male; Piroxicam; Rats; Rats, Inbred F344 | 1987 |
Proliferative instability and experimental carcinogenesis at colonic anastomoses.
Topics: Animals; Azoxymethane; Cell Division; Colon; Colonic Neoplasms; Epithelium; Intestinal Mucosa; Male; Rats; Rats, Inbred Strains; Time Factors; Wound Healing | 1987 |
Chemoprevention of colon carcinogenesis by dietary organoselenium, benzylselenocyanate, in F344 rats.
Topics: Administration, Oral; Animals; Azoxymethane; Colonic Neoplasms; Cyanates; Diet; Male; Organoselenium Compounds; Rats; Rats, Inbred F344; Selenium; Thiocyanates | 1987 |
Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: preliminary findings.
Topics: Animals; Azoxymethane; Colon; Colonic Neoplasms; Female; Mice; Mice, Inbred C57BL | 1987 |
Effect of dietary fish oil on azoxymethane-induced colon carcinogenesis in male F344 rats.
Topics: Animals; Azo Compounds; Azoxymethane; Body Weight; Colonic Neoplasms; Dietary Fats; Energy Intake; Fatty Acids, Unsaturated; Fishes; Male; Oils; Rats; Zea mays | 1986 |
Changes in crypt cell DNA content during experimental colonic carcinogenesis.
Topics: Animals; Azoxymethane; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; DNA; Intestinal Mucosa; Male; Precancerous Conditions; Rats; Rats, Inbred Strains | 1986 |
Effect of warfarin on formation and growth of pre-neoplastic lesions in chemically induced colorectal cancer in the rat.
Topics: Adenoma; Animals; Azoxymethane; Colon; Colonic Neoplasms; Disease Models, Animal; Intestinal Mucosa; Male; Microscopy, Electron, Scanning; Precancerous Conditions; Random Allocation; Rats; Rats, Inbred Strains; Rectal Neoplasms; Rectum; Warfarin | 1986 |
Kinetic changes in mucosal ornithine decarboxylase activity during azoxymethane-induced colonic carcinogenesis in the rat.
Topics: Animals; Azo Compounds; Azoxymethane; Carcinoma; Cell Cycle; Colonic Neoplasms; Enzyme Induction; Intestinal Mucosa; Kinetics; Male; Ornithine Decarboxylase; Rats | 1986 |
Effect of restricted caloric intake on azoxymethane-induced colon tumor incidence in male F344 rats.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Dietary Fats; Dietary Proteins; Energy Intake; Male; Rats; Rats, Inbred F344 | 1987 |
Effects of chronic dietary beer and ethanol consumption on experimental colonic carcinogenesis by azoxymethane in rats.
Topics: Alcohol Drinking; Animals; Azoxymethane; Beer; Bile Acids and Salts; Body Weight; Cell Division; Colon; Colonic Neoplasms; DNA; Energy Intake; Epithelium; Feces; Male; Rats; Rats, Inbred F344; Sterols | 1987 |
Elevated plasma enteroglucagon alone fails to alter distal colonic carcinogenesis in rats.
Topics: Animals; Azoxymethane; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Gastrointestinal Hormones; Glucagon-Like Peptides; Jejunoileal Bypass; Male; Organ Size; Rats; Rats, Inbred Strains | 1987 |
Enteroglucagon and experimental intestinal carcinogenesis in the rat.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Duodenal Neoplasms; Gastrointestinal Hormones; Glucagon-Like Peptides; Intestinal Neoplasms; Male; Rats; Rats, Inbred Strains | 1987 |
Effects of carcinogen dosage on experimental colonic carcinogenesis by azoxymethane: an ultrastructural study of grossly normal colonic mucosa.
Topics: Animals; Azo Compounds; Azoxymethane; Cell Membrane; Cell Nucleus; Colon; Colonic Neoplasms; Cytoplasm; Dose-Response Relationship, Drug; Intestinal Mucosa; Male; Mitosis; Rats; Rats, Inbred F344 | 1985 |
Effect of different levels of dietary trans fat or corn oil on azoxymethane-induced colon carcinogenesis in F344 rats.
Topics: Animals; Azoxymethane; Bile Acids and Salts; Cocarcinogenesis; Colonic Neoplasms; Corn Oil; Dietary Fats; Energy Intake; Female; Oils; Rats; Rats, Inbred F344 | 1985 |
Comments on comparative pathology of colonic neoplasia in cotton-top marmoset (Saguinus oedipus oedipus).
Topics: 1,2-Dimethylhydrazine; Animal Diseases; Animals; Azoxymethane; Callitrichinae; Colitis, Ulcerative; Colonic Neoplasms; Dimethylhydrazines; Histocytochemistry; Humans; Intestinal Mucosa; Rats; Saguinus | 1985 |
Effects of dietary saturated and unsaturated fatty acids on fecal bile acids and colon carcinogenesis induced by azoxymethane in rats.
Topics: Animals; Azo Compounds; Azoxymethane; Bile Acids and Salts; Cholesterol; Cholesterol Esters; Colonic Neoplasms; Dietary Fats; Fatty Acids; Fatty Acids, Unsaturated; Feces; Intestinal Mucosa; Liver; Lysophosphatidylcholines; Male; Phospholipids; Rats | 1986 |
Rat colonic mucosal cell sialic acid metabolism in azoxymethane-induced tumours.
Topics: Animals; Azoxymethane; Colonic Neoplasms; DNA; DNA, Neoplasm; Intestinal Mucosa; Male; N-Acetylneuraminic Acid; Neoplasm Proteins; Proteins; Rats; Rats, Inbred Strains; Sialic Acids | 1985 |
Effect of warfarin on cell kinetics, epithelial morphology and tumour incidence in induced colorectal cancer in the rat.
Topics: Adenoma; Animals; Azoxymethane; Cell Cycle; Colon; Colonic Neoplasms; Epithelium; Male; Microscopy, Electron, Scanning; Rats; Rats, Inbred Strains; Rectal Neoplasms; Rectum; Warfarin | 1985 |
Effect of deoxycholic acid on the tumour incidence, distribution, and receptor status of colorectal cancer in the rat model.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Deoxycholic Acid; Disease Models, Animal; Male; Rats; Rats, Inbred Strains; Receptors, Steroid; Rectal Neoplasms | 1985 |
Effect of dietary Laminaria angustata (brown seaweed) on azoxymethane-induced intestinal carcinogenesis in male F344 rats.
Topics: Adenocarcinoma; Animals; Azoxymethane; Cholesterol; Colon; Colonic Neoplasms; Intestinal Polyps; Laminaria; Male; Rats; Rats, Inbred F344; Seaweed; Sterols | 1985 |