azoxymethane has been researched along with Cell Transformation, Neoplastic in 138 studies
*Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (2.90) | 18.7374 |
| 1990's | 7 (5.07) | 18.2507 |
| 2000's | 39 (28.26) | 29.6817 |
| 2010's | 72 (52.17) | 24.3611 |
| 2020's | 16 (11.59) | 2.80 |
| Authors | Studies |
|---|---|
| Chan, AWH; Coker, OO; Lau, HCH; Li, C; Lin, Y; Sung, JJY; Szeto, CH; Wei, H; Yang, J; Yu, J; Zhou, Y | 1 |
| Bou-Dargham, M; Chen, YH; Etwebi, Z; Goldsmith, JR; Hood, R; Lengner, C; Li, M; Liu, S; Lou, Y; Spitofsky, N; Sun, H; Tian, Y | 1 |
| Chen, IJ; Chen, YL; Cheng, KW; Cheng, TL; Chuang, CH; Ho, KW; Huang, BC; Huang, MY; Leu, YL; Lin, WW; Liu, HJ; Roffler, SR; Tseng, CH; Wang, JY | 1 |
| Chang, J; Geng, Z; Hao, X; Liu, J; Tan, X; Wang, Z; Yan, S | 1 |
| Bouznad, N; Brocker, T; Friedrich, V; Garzetti, D; Hermeking, H; Krebs, S; Krug, AB; Lutz, K; Matzek, D; Metzger, R; Öllinger, R; Rad, R; Rokavec, M; Schäfer, Y; Stecher, B; von Armansperg, B; Winheim, E; Winter, L | 1 |
| Jiang, Q; Jones-Hall, Y; Liu, KY; Nakatsu, CH; Wang, Q | 1 |
| Chen, C; El-Nezami, H; Ismaiah, MJ; Leung, HKM; Lo, EKK; Zhang, F | 1 |
| Bullard, BM; Cardaci, TD; Fan, D; Hofseth, LJ; Huss, AR; McDonald, SJ; Murphy, EA; VanderVeen, BN | 1 |
| Chen, Y; Li, P; Liang, J; Luo, X; Wang, Q; Xie, X; Yang, C; Zhang, M; Zhou, L | 1 |
| Chen, X; Deng, Y; He, F; Huang, X; Tian, L; Wang, M; Yang, W; Yin, W; Zhou, H | 1 |
| Djurhuus, D; Nielsen, B; Olsen, J; Pedersen, AE; Sadowska, Z; Tougaard, P; Yassin, M | 1 |
| Chen, X; Decker, EA; Kim, D; Ma, Q; Park, Y; Qi, W; Sanidad, KZ; Yang, R; Zhang, G; Zhang, J | 1 |
| Eun, CS; Han, DS; Jo, SV; Lee, AR; Lee, JG; Park, CH | 1 |
| Allred, CD; Allred, KF; Callaway, ES; Chapkin, RS; Davidson, LA; DeLuca, JAA; Garcia-Villatoro, EL; Hensel, ME; Ivanov, I; Jayaraman, A; Menon, R; Safe, SH | 1 |
| Hartung, NM; Kühl, AA; McDonald, FM; Ostermann, AI; Rohwer, N; Schebb, NH; Weylandt, KH; Zopf, D | 1 |
| Benninghoff, AD; Hintze, KJ; Hunter, AH; Monsanto, SP; Pestka, JJ; Phatak, S; Rodriguez, DM; Ward, RE; Wettere, AJV | 1 |
| Chan, H; Chan, MTV; Coker, OO; Gin, T; Hu, W; Huang, D; Kang, W; Li, Q; Liu, WX; Liu, XD; Ng, SSM; Wong, SH; Wu, JL; Wu, WKK; Yu, J; Zeng, JD; Zhang, L; Zhang, Y; Zhao, LY | 1 |
| Barrett, CW; Burk, RF; Chen, X; Denson, LA; Haberman, Y; Hendren, JR; Hill, KE; Hyams, JS; Keating, CE; Marsh, BJ; Motley, AK; Pilat, JM; Reddy, VK; Rosen, MJ; Shi, C; Short, SP; Washington, MK; Williams, CS; Wilson, KT; Zemper, AE | 1 |
| Chen, L; Cheung, S; Feng, Y; He, W; Li, Z; McDonald, F; Tao, L; Wang, G; Yang, J; Yang, M; Zhang, Y; Zhong, X | 1 |
| Chan, FKL; Han, J; Kwong, TNY; Nakatsu, G; Sung, JJY; Tsoi, H; Wei, H; Wong, SH; Wu, WKK; Xiao, X; Xu, W; Yu, J; Zeng, B; Zhang, X; Zhao, L | 1 |
| Bader, JE; Carson, JA; Carson, MS; Chatzistamou, I; Davis, JM; Enos, RT; Murphy, EA; Nagarkatti, M; Nagarkatti, PS; Robinson, CM; Velázquez, KT | 1 |
| Cui, SX; Qu, XJ; Wang, F; Zhang, YS | 1 |
| Kim, JS; Kim, N; Lee, DH; Lee, HN; Lee, SM; Na, HY; Nam, RH; Park, JH; Shin, E; Sohn, SH; Son, HJ; Song, CH; Surh, YJ | 1 |
| Cui, K; Li, M; Li, Y; Lin, H; Shu, HB; Wang, SY; Wang, YY; Xia, T; Xu, ZS; Zhang, HX | 1 |
| Callaway, ES; Chapkin, RS; Ivanov, I; Jayaprakasha, GK; Kim, E; Patil, BS; Turner, ND; Wright, GA; Zoh, RS | 1 |
| Asami, Y; Hattori, N; Imai, T; Ishida, T; Kimura, K; Kobayashi, K; Mori, A; Mori, T; Niwa, T; Ushijima, T | 1 |
| Arias, M; Castro, M; Pardo, J; Santiago, L | 1 |
| Kamishima, M; Kawamura, T; Konno, H; Kurachi, K; Sakata, M; Setoh, M; Suzuki, K; Suzuki, Y; Takeuchi, H; Yamamoto, M | 1 |
| Akitake-Kawano, R; Chiba, T; Kanda, K; Kawada, K; Kawada, M; Kimura, Y; Nakanishi, Y; Nakatsuji, M; Sakai, Y; Seno, H; Yoshioka, T | 1 |
| Ji, G; Li, N; Tian, Y; Wang, K; Wang, Z | 1 |
| Drachenberg, C; Heath, J; Peng, Z; Raufman, JP; Xie, G | 1 |
| Agarwal, C; Agarwal, R; Balaiya, V; Derry, MM; Huber, KM; Jain, AK; Raina, K; Serkova, NJ; Shrotriya, S | 1 |
| Athar, M; Katiyar, SK | 1 |
| Kong, AN; Su, ZY; Zhang, C | 1 |
| Cai, M; Guo, Q; Hu, R; Li, Z; Wang, Q; Wang, Y; Yang, X; Zhang, F | 1 |
| Miller, MA; Neufeld, KL; Sullivan, R; Zeineldin, M | 1 |
| Cai, Z; Chen, X; Chen, Z; He, X; He, Z; Ke, J; Lan, P; Wu, X; Yuan, R | 1 |
| Artigiani Neto, R; Campanholo, VM; Forones, NM; Gollucke, AP; Landman, G; Oshima, CT; Paiotti, AP; Ribeiro, DA; Silva, RM | 1 |
| Ai, F; Li, G; Li, X; Ma, J; Peng, X; Shen, S; Wang, W; Wang, X; Xiong, W; Zhang, D; Zhang, X; Zheng, D; Zhou, Y | 1 |
| Craven, B; Egan, LJ; Martin, A; Mureau, C; Zaric, V | 1 |
| Ansary, MM; Fukuba, N; Ishihara, S; Kawashima, K; Kinoshita, Y; Kusunoki, R; Maruyama, R; Moriyama, I; Nabika, T; Oka, A; Oshima, N; Sonoyama, H; Tada, Y; Tajima, Y; Yuki, T | 1 |
| Burkitt, MD; Caamano, JH; Dimaline, R; Duckworth, CA; Gerondakis, S; Hanedi, AF; O'Reilly, LA; Pritchard, DM; Putoczki, TL; Tang, JM; Williams, JM | 1 |
| Dai, W; Lightfoot, S; Mohammed, A; Rao, CV; Reddy, A; Yamada, HY; Zhang, Y | 1 |
| Eaton, K; Yang, W | 1 |
| Chen, R; He, J; Kadegowda, AK; Shin, H; Wei, X; Xie, SK | 1 |
| Cai, Y; Golla, JP; Golla, S; Gonzalez, FJ; Korboukh, I; Krausz, KW; Manna, SK; Matsubara, T; Takahashi, S; Tanaka, N | 1 |
| Biffoni, M; Bignami, M; Boirivant, M; De Luca, G; Di Carlo, E; Di Meo, S; Grasso, F; Pasquini, L; Rossi, S | 1 |
| Bongiovanni, L; Burocchi, A; Colombo, MP; Danelli, L; Guarnotta, C; Lewis, A; Rigoni, A; Rizzo, A; Sangaletti, S; Silver, AR; Tripodo, C | 1 |
| Besselsen, DG; Caporaso, JG; Chase, JH; Ghishan, FK; Harrison, CA; Jobin, C; Kiela, PR; Larmonier, CB; McFadden, RM; Midura-Kiela, M; Ramalingam, R; Shehab, KW | 1 |
| Agarwal, R; Charepalli, V; Radhakrishnan, S; Reddivari, L; Vadde, R; Vanamala, JK | 1 |
| Buchert, M; Dashwood, RH; Eissmann, M; Ernst, M; Gnann, A; Heath, JK; Hirokawa, Y; Janssen, KP; Orend, G; Orner, G; Owen, A; Rohde, F; Tan, CW; Tebbutt, N; Williams, B | 1 |
| Byeon, JS; Cho, EA; Chung, EJ; Do, EJ; Hwang, SW; Kim, JH; Kim, SY; Lee, HJ; Myung, SJ; Park, S; Park, SH; Ryu, YM; Yang, DH; Yang, SK; Ye, BD | 1 |
| Chen, YH; Guo, C; Shi, Y; Wang, G; Wang, J; Wang, L; Wang, Q; Wang, X; Zhang, L; Zhao, M; Zhao, W; Zhu, F | 1 |
| Chaudhry, KK; Gangwar, R; Manda, B; Meena, AS; Mir, H; Rao, R; Shukla, PK; Yadav, N | 1 |
| Goto, N; Inoue, T; Kashimoto, S; Kukimoto-Niino, M; Masuda, M; Mimata, A; Moriyama, H; Ohata, H; Ohbayashi, N; Okamoto, K; Sawa, M; Shirouzu, M; Uno, Y; Yamada, T | 1 |
| Ahn, J; Assefnia, S; Bong, YS; Bueno De Mesquita, PJ; Burt, RW; Byers, SW; Neklason, DW; Tuohy, T | 1 |
| de Carvalho, JE; Dmitrieva, O; Francescone, R; Grivennikov, SI; Hensley, H; Hou, V; Pilli, RA; Posocco, D; Vendramini-Costa, DB | 1 |
| Brembeck, FH; Talla, SB | 1 |
| Inoue, M; Ishihara, A; Okamoto, Y; Tokumura, A; Tsutsumi, T | 1 |
| Gadaleta, RM; Garcia-Irigoyen, O; Moschetta, A | 1 |
| Fields, AP; Fujiwara, K; Kurakata, S; Murray, NR; Necela, BM; Su, W; Thompson, EA | 1 |
| Endo, H; Fujisawa, T; Inamori, M; Kadowaki, T; Kubota, N; Nakagama, H; Nakajima, A; Nakajima, N; Saito, S; Sugiyama, M; Takahashi, H; Tomimoto, A; Wada, K; Watanabe, M; Yamauchi, T | 1 |
| Bielawski, J; Hannun, YA; Kaneshiro, T; Kawamori, T; Maalouf, S; Obeid, LM; Okumura, M; Uflacker, A | 1 |
| Braun, U; Fields, AP; Leitges, M; Murray, NR; Weems, J | 1 |
| Hao, X; Ju, J; Lambert, JD; Lee, MJ; Lu, G; Newmark, HL; Xiao, H; Yang, CS | 1 |
| Kang, YH; Kim, DH; Kim, JK; Kim, YH; Kwon, HS; Park, JH; Shin, EK; Shin, HK | 1 |
| Begleiter, A; Bird, RP; Lefas, GM; Maksymiuk, AW; Sivananthan, K | 1 |
| Caderni, G; Dolara, P; Femia, AP; Luceri, C; Salvadori, M | 1 |
| Fujimoto, K; Fujise, T; Iwakiri, R; Kakimoto, T; Kuroki, T; Miao, L; Noda, T; Sakata, Y; Shiraishi, R; Tsunada, S | 1 |
| Endo, H; Fujisawa, T; Fujita, K; Hosono, K; Inamori, M; Nakagama, H; Nakajima, A; Nozaki, Y; Sugiyama, M; Takahashi, H; Wada, K; Yoneda, K; Yoneda, M | 1 |
| Denda, A; Fujii, K; Kuniyasu, H; Luo, Y; Ohmori, H; Sasahira, T | 1 |
| Bade, LK; Cormier, RT; Fijneman, RJ; Meijer, GA; O'Sullivan, MG; Peham, JR; van de Wiel, MA; van Hinsbergh, VW | 1 |
| Bouhadjar, M; Bousserouel, S; Gosse, F; Marescaux, J; Raul, F; Soler, L | 1 |
| Ashton-Rickardt, P; Chen, L; Park, SM; Peter, ME; Turner, JR; Zhang, M | 1 |
| Ergang, P; Kment, M; Mandys, V; Pácha, J; Svec, J | 1 |
| Barney, KA; Blevins, EA; Finkelman, FD; Flick, MJ; Harmel-Laws, E; Horowitz, NA; Kombrinck, KW; Palumbo, JS; Pinkerton, MD; Shaw, MA; Steinbrecher, KA; Talmage, KE; Witte, DP | 1 |
| Bouhadjar, M; Bousserouel, S; Gossé, F; Kauntz, H; Marescaux, J; Raul, F; Soler, L | 1 |
| Li, P; Pitari, GM; Schulz, S; Waldman, SA | 2 |
| Bala, S; DeSchryver, K; Jiang, S; Levin, MS; Newberry, R; Onal, B; Rubin, DC; Shaker, A; Swietlicki, EA; Wang, L | 1 |
| Aoi, W; Hung, LP; Ichikawa, H; Kawai, Y; Kokura, S; Koyama, R; Mizushima, K; Naito, Y; Takagi, T; Takanami, Y; Tanimura, Y; Yoshikawa, T | 1 |
| Bean, E; Currey, N; Dahlstrom, JE; Daniel, JJ; Gupta, R; Kohonen-Corish, MR; Mladenova, D; Musgrove, EA; Pickford, R | 1 |
| Byeon, JS; Do, EJ; Do, MY; Kim, IW; Kim, JH; Kim, MJ; Myung, SJ; Park, S; Ryu, YM; Yang, SK; Ye, BD; Yoon, SM | 1 |
| Barrett, CW; Chaturvedi, R; Fingleton, B; Fischer, MA; Hiebert, SW; Ning, W; Washington, MK; Williams, A; Williams, CS; Wilson, KT | 1 |
| Backman, V; Brasky, J; Cornwell, ML; Crawford, SE; De La Cruz, M; Gibson, TP; Gomes, A; Kunte, DP; Mutyal, N; Radosevich, A; Roy, HK; Ruderman, S; Stypula, Y; Tiwari, AK; Wali, RK | 1 |
| Birt, DF; Boddicker, RL; Spurlock, ME; Whitley, E | 1 |
| Birt, DF; Boddicker, RL; Davis, JE; Spurlock, ME; Whitley, EM | 1 |
| Akira, S; Hara, S; Ishii, T; Ishikawa, Y; Kamei, D; Murakami, M; Sasaki, Y; Uematsu, S | 1 |
| Li, TW; Lu, SC; Mato, JM; Peng, H; Xia, M; Yang, H | 1 |
| Banning, A; Brauer, MN; Brigelius-Flohé, R; Chu, FF; Esworthy, RS; Florian, S; Iori, R; Kipp, AP; Krehl, S; Loewinger, M; Wessjohann, LA | 1 |
| Broaddus, RR; Fischer, SM; Morris, JS; Moussalli, MJ; Parker-Thornburg, J; Peng, Z; Shureiqi, I; Wang, Y; Wu, Y; Yang, XL; Zuo, X | 1 |
| Dubeykovskiy, A; Jin, G; Ramanathan, V; Takaishi, S; Wang, TC; Westphalen, CB; Whelan, A | 1 |
| Bousserouel, S; Gosse, F; Kauntz, H; Marescaux, J; Raul, F | 1 |
| Erwin, CR; Guo, J; Liu, J; Schneider, JE; Stappenbeck, TS; Wakeman, D; Wandu, WS; Warner, BW | 1 |
| Abujamel, T; Arthur, JC; Campbell, BJ; Dogan, B; Fan, TJ; Fodor, AA; Hansen, JJ; Jobin, C; Keku, TO; Mühlbauer, M; Perez-Chanona, E; Rhodes, JM; Rogers, AB; Simpson, KW; Stintzi, A; Tomkovich, S; Uronis, JM | 1 |
| Clarke, M; Das, S; Huels, D; Jamieson, T; Jung, A; Neumann, J; Nibbs, RJ; Olson, MF; Samuel, MS; Sansom, OJ; Steele, CW | 1 |
| Ariyama, H; Asfaha, S; Dubeykovskaya, ZA; Dubeykovskiy, AN; Ericksen, R; Fox, JG; Friedman, RA; Frucht, H; Muthupalani, S; Shibata, W; Stokes, S; Tomita, H; Wang, TC; Yang, X | 1 |
| Koliaraki, V; Kollias, G; Roulis, M | 1 |
| Hara, A; Hatano, Y; Hirata, A; Hirose, Y; Kuno, T; Masuda, S; Mori, H; Tanaka, T; Terasaki, M; Tomita, H | 1 |
| Dionne, S; Elimrani, I; Levy, E; Qureshi, IA; Roy, MJ; Sarma, DR; Seidman, EG | 1 |
| Chong, PP; Ho, KL; Ismail, M; Yazan, LS | 1 |
| Baker, A; Colburn, NH; Dodge, LK; Gerard, M; Jiang, H; Toledano, MB; Wei, Q; Young, MR | 1 |
| Breinholt, V; Meyer, O; Mølck, AM; Poulsen, M; Thorup, I | 1 |
| Fujihara, H; Kamada, N; Kusuoka, O; Masutani, M; Nakagama, H; Nakamoto, K; Nozaki, T; Sugimura, T; Suzuki, H; Tsutsumi, M; Watanabe, M | 1 |
| Anastasiadis, P; Fields, AP; Gatalica, Z; Gökmen-Polar, Y; Jamieson, L; Murray, NR; Sier, D; Thompson, EA; Yu, W; Zhang, J | 1 |
| Fujita, K; Iigo, M; Matsuda, E; Sekine, K; Tsuda, H | 2 |
| Biswas, S; Chytil, A; Gautam, S; Gorska, AE; Grady, WM; Moses, HL; Romero-Gallo, J; Washington, K; Wirth, PS | 1 |
| Kral, JG; Stein, DE | 1 |
| Bozinov, D; Callaway, ES; Chapkin, RS; Davidson, LA; Finnell, RH; James, J; Kappen, C; Lupton, JR; Ma, DW; Piedrahita, JA; Salbaum, JM; Spiegelstein, O; Weeks, BR | 1 |
| Aniya, Y; Ichiba, T; Inamine, M; Morioka, T; Nabandith, V; Nakayama, T; Suzui, M; Yoshimi, N | 1 |
| Backman, V; Goldberg, MJ; Kim, YL; Koetsier, JL; Kunte, DP; Liu, Y; Roy, HK; Turzhitsky, V; Wali, RK | 1 |
| Becker, C; Fantini, MC; Galle, PR; Kiesslich, R; Lehr, HA; Neurath, MF; Nikolaev, A; Wirtz, S | 1 |
| Denda, A; Ichiba, M; Kuniyasu, H; Sasahira, T; Sasaki, T; Shimomoto, T; Shimura, H; Yoshida, K | 1 |
| Backman, V; Goldberg, MJ; Horwitz, J; Kim, YL; Liu, Y; Roy, HK; Turzhitsky, V; Wali, RK | 1 |
| Fujii, K; Kuniyasu, H; Sasahira, T; Sasaki, T; Shimura, H | 1 |
| Fujimoto, K; Fujise, T; Iwakiri, R; Kakimoto, T; Ootani, A; Sakata, Y; Shiraishi, R; Tsunada, S; Wu, B | 1 |
| Bissonnette, M; Cerda, S; Cohen, G; Dougherty, U; Fichera, A; Gong, C; Hart, J; Jagadeeswaran, S; Joseph, L; Khare, S; Little, N; Mustafi, R; Sehdev, A; Tallerico, M; Tretiakova, M; Turner, JR; Yuan, W | 1 |
| Baran, AA; Bombonati, A; Hyslop, TM; Li, P; Palazzo, JP; Pitari, GM; Schulz, S; Siracusa, LD; Waldman, SA; Xu, Y | 1 |
| DeAngelo, AB; Jones, CP; Moyer, MP | 1 |
| Fujii, C; Kagaya, T; Kaneko, S; Kitamura, K; Kondo, T; Mukaida, N; Oshima, M; Popivanova, BK; Wu, Y | 1 |
| Brooke, DA; Coletta, PL; Cuthbert, RJ; Hull, MA; Ko, CW; Markham, AF; Orsi, NM; Perry, SL | 1 |
| Simmen, FA; Simmen, RC; Su, Y; Xiao, R | 1 |
| Blumberg, RS; Fujisawa, N; Fujisawa, T; Ikeda, I; Kadowaki, T; Kubota, N; Kudo, C; Nakagama, H; Nakajima, A; Nakajima, N; Takahashi, H; Terauchi, Y; Tomimoto, A; Wada, K; Yonemitsu, K | 1 |
| Cheng, K; Drachenberg, C; Khurana, S; Raufman, JP; Samimi, R; Shah, N; Shant, J; Wess, J; Xie, G | 1 |
| Aust, JB; Moyer, MP | 1 |
| Bissonnette, M; Brasitus, TA; Hart, J; Khare, S; Sitrin, MD; Wali, RK | 1 |
| Bissonnette, M; Brasitus, TA; Earnest, D; Frawley, BP; Niedziela, SM; Roy, HK; Wali, RK | 1 |
| Allan, C; Brasitus, TA; Rigas, B; Tsioulias, GJ; Wali, RK | 1 |
| Altmann, GG; Lala, PK | 1 |
| Bazzicalupo, M; Briani, C; Caderni, G; De Filippo, C; Dolara, P; Fazi, M; Giannini, A | 1 |
| Kawamori, T; Kelloff, GJ; Lubet, RA; Rao, CV; Reddy, BS; Steele, VE | 1 |
| Hanausek, M; Mori, H; Slaga, TJ; Szemraj, J; Walaszek, Z; Yoshimi, N | 1 |
| Kral, JG; Scholes, J; Stein, DE; Weber, RV | 1 |
| Baba, M; Ichii, M; Iishi, H; Nakaizumi, A; Taniguchi, H; Tatsuta, M; Uehara, H | 1 |
| Curt, A; Izbicki, JR; Kusche, J; Mennigen, R; Parkin, JV | 1 |
| Cooke, T; Matthews, J | 1 |
| Bloom, SR; Bristol, JB; Ghatei, MA; Smith, JH; Williamson, RC | 1 |
138 other study(ies) available for azoxymethane and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
High-Fat Diet Promotes Colorectal Tumorigenesis Through Modulating Gut Microbiota and Metabolites.
Topics: Animals; Anti-Bacterial Agents; Azoxymethane; Bacteria; Bacterial Translocation; Cell Proliferation; Cell Transformation, Neoplastic; Colon; Colorectal Neoplasms; Diet, High-Fat; Disease Models, Animal; Dysbiosis; Fecal Microbiota Transplantation; Feces; Gastrointestinal Microbiome; Genes, APC; Germ-Free Life; Humans; Lysophospholipids; Male; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Permeability; Tumor Cells, Cultured | 2022 |
TIPE2 Promotes Tumor Initiation But Inhibits Tumor Progression in Murine Colitis-Associated Colon Cancer.
Topics: Animals; Azoxymethane; Cell Transformation, Neoplastic; Colitis; Colitis-Associated Neoplasms; Colon; Dextran Sulfate; Disease Models, Animal; Inflammation; Inflammatory Bowel Diseases; Intracellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL | 2022 |
Inhibition of gut microbial β-glucuronidase effectively prevents carcinogen-induced microbial dysbiosis and intestinal tumorigenesis.
Topics: Animals; Azoxymethane; Bacteria; Carcinogenesis; Carcinogens; Cell Transformation, Neoplastic; Colorectal Neoplasms; Dysbiosis; Gastrointestinal Microbiome; Glucuronidase; Mice | 2022 |
Berberine regulates short-chain fatty acid metabolism and alleviates the colitis-associated colorectal tumorigenesis through remodeling intestinal flora.
Topics: Animals; Azoxymethane; Berberine; Carcinogenesis; Cell Transformation, Neoplastic; Colitis; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Fatty Acids, Volatile; Gastrointestinal Microbiome; Interleukin-6; Lipopolysaccharides; Mice; Mice, Inbred C57BL; NF-kappa B; Occludin; Tandem Mass Spectrometry; Toll-Like Receptor 4 | 2022 |
CCL17 Promotes Colitis-Associated Tumorigenesis Dependent on the Microbiota.
Topics: Animals; Azoxymethane; Carcinogenesis; Cell Transformation, Neoplastic; Chemokine CCL17; Colitis; Colonic Neoplasms; Gastrointestinal Microbiome; Mice | 2022 |
Combining gamma-tocopherol and aspirin synergistically suppresses colitis-associated colon tumorigenesis and modulates the gut microbiota in mice, and inhibits the growth of human colon cancer cells.
Topics: Animals; Aspirin; Azoxymethane; Carcinogenesis; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Dextran Sulfate; gamma-Tocopherol; Gastrointestinal Microbiome; Humans; Mice; Mice, Inbred C57BL | 2023 |
Zearalenone attenuates colitis associated colorectal tumorigenesis through Ras/Raf/ERK pathway suppression and SCFA-producing bacteria promotion.
Topics: Animals; Azoxymethane; Bacteria; Carcinogenesis; Cell Transformation, Neoplastic; Colitis; Colorectal Neoplasms; Cyclin D1; Dextran Sulfate; Disease Models, Animal; Humans; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Zearalenone | 2023 |
Panaxynol alleviates colorectal cancer in a murine model via suppressing macrophages and inflammation.
Topics: Animals; Azoxymethane; Carcinogenesis; Cell Transformation, Neoplastic; Colitis; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Inflammation; Macrophages; Mice; Mice, Inbred C57BL; Mucins | 2023 |
Astragaloside IV inhibits AOM/DSS-induced colitis-associated tumorigenesis via activation of PPARγ signaling in mice.
Topics: Animals; Azoxymethane; Carcinogenesis; Cell Transformation, Neoplastic; Colitis; Dextran Sulfate; Disease Models, Animal; Inflammation; Mice; Mice, Inbred C57BL; PPAR gamma; Reactive Oxygen Species | 2023 |
Chemopreventive Effects of Polysaccharides and Flavonoids from Okra Flowers in Azomethane/Dextran Sulfate Sodium-Induced Murine Colitis-Associated Cancer.
Topics: Abelmoschus; Animals; Anticarcinogenic Agents; Azoxymethane; beta Catenin; Carcinogenesis; Cell Transformation, Neoplastic; Colitis; Colitis-Associated Neoplasms; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Flavonoids; Hominidae; Humans; Interleukin-6; Mice; Mice, Inbred C57BL; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt | 2023 |
Upregulation of PD-1 follows tumour development in the AOM/DSS model of inflammation-induced colorectal cancer in mice.
Topics: Animals; Azoxymethane; B7-H1 Antigen; Cell Transformation, Neoplastic; Colitis; Colon; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Intestinal Mucosa; Lymphocyte Activation; Mice, Inbred C57BL; Phenotype; Programmed Cell Death 1 Ligand 2 Protein; Programmed Cell Death 1 Receptor; Signal Transduction; T-Lymphocytes; Up-Regulation | 2019 |
Thermally Processed Oil Exaggerates Colonic Inflammation and Colitis-Associated Colon Tumorigenesis in Mice.
Topics: Animals; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Hot Temperature; Humans; Inflammation; Male; Mice; Mice, Inbred C57BL; Oils | 2019 |
The impact of gut microbiota manipulation with antibiotics on colon tumorigenesis in a murine model.
Topics: Animals; Anti-Bacterial Agents; Azoxymethane; Carcinogenesis; Cell Transformation, Neoplastic; Colitis; Colorectal Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; Female; Gastrointestinal Microbiome; High-Throughput Nucleotide Sequencing; Inflammation; Mice; Mice, Inbred C57BL; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Tumor Burden | 2019 |
Effects of high-fat diet and intestinal aryl hydrocarbon receptor deletion on colon carcinogenesis.
Topics: Animals; Azoxymethane; Basic Helix-Loop-Helix Transcription Factors; beta Catenin; Cell Proliferation; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Diet, High-Fat; Disease Models, Animal; DNA Damage; Epithelial Cells; Gene Deletion; Gene Expression Regulation, Neoplastic; Intestinal Mucosa; Mice, Inbred C57BL; Mice, Knockout; Precancerous Conditions; Receptors, Aryl Hydrocarbon; Signal Transduction | 2020 |
Effects of chronic low-dose aspirin treatment on tumor prevention in three mouse models of intestinal tumorigenesis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Azoxymethane; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; Colitis-Associated Neoplasms; Colorectal Neoplasms; Dextran Sulfate; Dose-Response Relationship, Drug; Female; Intestinal Neoplasms; Male; Mice; Mice, Inbred C57BL; Tumor Cells, Cultured | 2020 |
Consumption of the Total Western Diet Promotes Colitis and Inflammation-Associated Colorectal Cancer in Mice.
Topics: Adaptive Immunity; Animals; Azoxymethane; Carcinogenesis; Cell Transformation, Neoplastic; Colitis; Colon; Colorectal Neoplasms; Dextran Sulfate; Diet, Western; Disease Models, Animal; Immunity, Innate; Inflammation; Intestinal Mucosa; Mice; Mice, Inbred C57BL; RNA, Messenger | 2020 |
Streptococcus thermophilus Inhibits Colorectal Tumorigenesis Through Secreting β-Galactosidase.
Topics: Adenomatous Polyposis Coli Protein; Animals; Azoxymethane; Bacterial Proteins; beta-Galactosidase; Cell Line, Tumor; Cell Transformation, Neoplastic; Colon; Colorectal Neoplasms; Humans; Intestinal Mucosa; Male; Mice; Mice, Transgenic; Neoplasms, Experimental; Probiotics; Streptococcus thermophilus | 2021 |
Colonic Epithelial-Derived Selenoprotein P Is the Source for Antioxidant-Mediated Protection in Colitis-Associated Cancer.
Topics: Adolescent; Animals; Azoxymethane; Case-Control Studies; Cell Transformation, Neoplastic; Child; Child, Preschool; Colitis; Colitis-Associated Neoplasms; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; DNA Damage; Female; Genomic Instability; Humans; Intestinal Mucosa; Liver; Male; Mice, Knockout; Myeloid Cells; Oxidative Stress; Selenoprotein P | 2021 |
Aspirin inhibits prostaglandins to prevents colon tumor formation via down-regulating Wnt production.
Topics: Animals; Aspirin; Azoxymethane; Cell Transformation, Neoplastic; Colitis; Colitis-Associated Neoplasms; Dextran Sulfate; Dinoprostone; Disease Models, Animal; Down-Regulation; Humans; Male; Mice; Nuclear Receptor Subfamily 4, Group A, Member 2; Proteomics; Proto-Oncogene Proteins; Wnt Proteins; Wnt Signaling Pathway | 2021 |
Gavage of Fecal Samples From Patients With Colorectal Cancer Promotes Intestinal Carcinogenesis in Germ-Free and Conventional Mice.
Topics: Animals; Azoxymethane; Case-Control Studies; Cell Proliferation; Cell Transformation, Neoplastic; Colon; Colonic Polyps; Colorectal Neoplasms; Disease Models, Animal; Feces; Gastrointestinal Microbiome; Gene Expression Regulation, Neoplastic; Germ-Free Life; Host-Pathogen Interactions; Humans; Inflammation Mediators; Ki-67 Antigen; Lymphocytes, Tumor-Infiltrating; Male; Mice, Inbred C57BL; Th1 Cells; Th17 Cells | 2017 |
Macrophage depletion using clodronate liposomes decreases tumorigenesis and alters gut microbiota in the AOM/DSS mouse model of colon cancer.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Biomarkers, Tumor; Cell Transformation, Neoplastic; Clodronic Acid; Colon; Colonic Polyps; Colorectal Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Microbiome; Host-Pathogen Interactions; Inflammation Mediators; Liposomes; Macrophages; Male; Mice, Inbred C57BL; Signal Transduction; Time Factors; Tumor Burden | 2018 |
Natural dietary compound naringin prevents azoxymethane/dextran sodium sulfate-induced chronic colorectal inflammation and carcinogenesis in mice.
Topics: Animals; Autophagy; Azoxymethane; Biomarkers; Cell Transformation, Neoplastic; Colitis; Colorectal Neoplasms; Cytokines; Dietary Supplements; Disease Models, Animal; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Flavanones; Inflammation Mediators; Intestinal Mucosa; Male; Mice; Sulfates | 2018 |
Effect of Estradiol in an Azoxymethane/Dextran Sulfate Sodium-Treated Mouse Model of Colorectal Cancer: Implication for Sex Difference in Colorectal Cancer Development.
Topics: Animals; Azoxymethane; Biomarkers; Biopsy; Carcinogens; Cell Transformation, Neoplastic; Colorectal Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; Disease Progression; Disease Susceptibility; Estradiol; Female; Humans; Immunohistochemistry; Inflammation Mediators; Male; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Sex Factors | 2019 |
TRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis.
Topics: Animals; Azoxymethane; Carcinogenesis; Cell Line, Tumor; Cell Transformation, Neoplastic; Colitis; Dextran Sulfate; DNA-Binding Proteins; HEK293 Cells; HeLa Cells; HT29 Cells; Humans; Interleukin-6; Mice; Nuclear Proteins; Signal Transduction; STAT3 Transcription Factor; Ubiquitin-Protein Ligases | 2018 |
Establishment of a multicomponent dietary bioactive human equivalent dose to delete damaged Lgr5+ stem cells using a mouse colon tumor initiation model.
Topics: Animals; Apoptosis; Azoxymethane; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Curcumin; Dietary Supplements; Dose-Response Relationship, Drug; Fatty Acids, Omega-3; Female; Gene Knock-In Techniques; Humans; Intestinal Mucosa; Male; Mice; Mice, Transgenic; Neoplasms, Experimental; Neoplastic Stem Cells; Receptors, G-Protein-Coupled | 2019 |
Antibiotics suppress colon tumorigenesis through inhibition of aberrant DNA methylation in an azoxymethane and dextran sulfate sodium colitis model.
Topics: Animals; Anti-Bacterial Agents; Azoxymethane; Cell Transformation, Neoplastic; Colitis, Ulcerative; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; DNA Methylation; Gastrointestinal Microbiome; Humans; Intestinal Mucosa; Male; Mice, Inbred BALB C | 2019 |
Mouse Model of Colitis-Associated Colorectal Cancer (CAC): Isolation and Characterization of Mucosal-Associated Lymphoid Cells.
Topics: Animals; Azoxymethane; Cell Separation; Cell Transformation, Neoplastic; Centrifugation, Density Gradient; Colitis, Ulcerative; Colon; Colorectal Neoplasms; Dextran Sulfate; Flow Cytometry; Humans; Intestinal Mucosa; Lymphocytes; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasms, Experimental | 2019 |
Tenascin-C Produced by Intestinal Myofibroblasts Promotes Colitis-associated Cancer Development Through Angiogenesis.
Topics: Animals; Azoxymethane; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Dextran Sulfate; Gene Expression Profiling; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Myofibroblasts; Neovascularization, Pathologic; Tenascin | 2019 |
Inhibitory role of Gas6 in intestinal tumorigenesis.
Topics: Aged; Aged, 80 and over; Animals; Azoxymethane; Bone Marrow; Bone Marrow Transplantation; Cell Proliferation; Cell Transformation, Neoplastic; Colitis; Colorectal Neoplasms; Dextran Sulfate; Disease Progression; Female; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Intercellular Signaling Peptides and Proteins; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Monocytes; NF-kappa B; Prognosis; Recombinant Proteins; RNA, Messenger; Suppressor of Cytokine Signaling 1 Protein; Suppressor of Cytokine Signaling Proteins | 2013 |
Chemopreventive effect of dietary glutamine on colitis-associated colon tumorigenesis in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Azoxymethane; Biomarkers, Tumor; Blotting, Western; Cell Proliferation; Cell Transformation, Neoplastic; Chemoprevention; Colitis; Colon; Colorectal Neoplasms; Cyclooxygenase 2; Dextran Sulfate; Dietary Supplements; Enzyme-Linked Immunosorbent Assay; Female; Glutamine; Immunohistochemistry; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Nitric Oxide Synthase Type II; Real-Time Polymerase Chain Reaction; Rectum; Severity of Illness Index | 2013 |
Cholinergic muscarinic receptor activation augments murine intestinal epithelial cell proliferation and tumorigenesis.
Topics: Adenocarcinoma; Animals; Azoxymethane; Bethanechol; Cell Proliferation; Cell Transformation, Neoplastic; Colonic Neoplasms; Cyclin D1; Cyclooxygenase 2; ErbB Receptors; Gene Expression; Hypoxia-Inducible Factor 1, alpha Subunit; Intestinal Mucosa; Male; Matrix Metalloproteinase 10; Matrix Metalloproteinase 13; Matrix Metalloproteinase 7; Mice; Muscarinic Agonists; Proto-Oncogene Proteins c-myc; Receptor, Muscarinic M3; RNA, Messenger; Signal Transduction; Tumor Burden | 2013 |
Grape seed extract efficacy against azoxymethane-induced colon tumorigenesis in A/J mice: interlinking miRNA with cytokine signaling and inflammation.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Azoxymethane; beta Catenin; Biomarkers, Tumor; Blotting, Western; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; Colonic Neoplasms; Cytokines; Extracellular Signal-Regulated MAP Kinases; Gene Expression Profiling; Grape Seed Extract; Immunoenzyme Techniques; Inflammation; Male; Mice; Mice, Inbred A; MicroRNAs; Mitogen-Activated Protein Kinases; NF-kappa B; Oligonucleotide Array Sequence Analysis; Phosphorylation; Signal Transduction | 2013 |
Grape seeds: ripe for cancer chemoprevention.
Topics: Animals; Antineoplastic Agents, Phytogenic; Azoxymethane; Cell Transformation, Neoplastic; Colonic Neoplasms; Grape Seed Extract; Male; MicroRNAs; Signal Transduction | 2013 |
Targeting epigenetics for cancer prevention by dietary cancer preventive compounds--the case of miRNA.
Topics: Animals; Antineoplastic Agents, Phytogenic; Azoxymethane; Cell Transformation, Neoplastic; Colonic Neoplasms; Grape Seed Extract; Male; MicroRNAs; Signal Transduction | 2013 |
Oroxylin A inhibits colitis-associated carcinogenesis through modulating the IL-6/STAT3 signaling pathway.
Topics: Animals; Azoxymethane; Blotting, Western; Carcinogens; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Dextran Sulfate; Female; Flavonoids; Fluorescent Antibody Technique; Humans; Immunoenzyme Techniques; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; STAT3 Transcription Factor | 2013 |
Nuclear adenomatous polyposis coli suppresses colitis-associated tumorigenesis in mice.
Topics: Adenomatous Polyposis Coli Protein; Animals; Apoptosis; Azoxymethane; beta Catenin; Blotting, Western; Carcinogens; Cell Nucleus; Cell Proliferation; Cell Transformation, Neoplastic; Colitis; Colorectal Neoplasms; Cyclooxygenase 2; Dextran Sulfate; Disease Models, Animal; Inflammation; Mice; Mutation; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction | 2014 |
Activation of the mTORC1 and STAT3 pathways promotes the malignant transformation of colitis in mice.
Topics: Animals; Antineoplastic Agents; Azoxymethane; Cell Transformation, Neoplastic; Colitis; Colorectal Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; Female; Gene Expression Regulation, Neoplastic; Humans; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred C57BL; Multiprotein Complexes; Signal Transduction; Sirolimus; STAT3 Transcription Factor; TOR Serine-Threonine Kinases | 2014 |
Grape juice concentrate (G8000™) modulates apoptosis but not oxidative stress following rat colon carcinogenesis induced by azoxymethane.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; bcl-2-Associated X Protein; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Deoxyguanosine; Disease Models, Animal; Fruit; Fruit and Vegetable Juices; Male; Oxidative Stress; Phytotherapy; Plants, Medicinal; Proto-Oncogene Proteins c-bcl-2; Rats, Wistar; Time Factors; Vitis | 2015 |
Dynamic changes and functions of macrophages and M1/M2 subpopulations during ulcerative colitis-associated carcinogenesis in an AOM/DSS mouse model.
Topics: Animals; Azoxymethane; Biomarkers; Carcinoma; Cell Transformation, Neoplastic; Colitis, Ulcerative; Colonic Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; Gene Expression; Hyperplasia; Inflammation Mediators; Macrophages; Male; Mice; Neoplasm Metastasis | 2015 |
Effect of genetic deletion or pharmacological antagonism of tumor necrosis factor alpha on colitis-associated carcinogenesis in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; Etanercept; Female; Mice; Mice, Knockout; NF-kappa B; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha | 2015 |
Role of milk fat globule-epidermal growth factor 8 in colonic inflammation and carcinogenesis.
Topics: Animals; Antigens, Surface; Azoxymethane; Body Weight; Cell Proliferation; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Epithelial Cells; Humans; Integrin alphaVbeta3; Intestinal Mucosa; Mice, Knockout; Milk Proteins; Neoplasm Proteins; Recombinant Proteins; Tumor Cells, Cultured | 2015 |
NF-κB1, NF-κB2 and c-Rel differentially regulate susceptibility to colitis-associated adenoma development in C57BL/6 mice.
Topics: Adenoma; Animals; Azoxymethane; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; Disease Susceptibility; Epithelial Cells; Female; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B p50 Subunit; NF-kappa B p52 Subunit; Proto-Oncogene Proteins c-rel; Signal Transduction | 2015 |
Tumor-promoting/progressing role of additional chromosome instability in hepatic carcinogenesis in Sgo1 (Shugoshin 1) haploinsufficient mice.
Topics: alpha-Fetoproteins; Animals; Azoxymethane; Carcinogens; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Line, Tumor; Cell Transformation, Neoplastic; Chromosomal Instability; DNA Damage; Female; Glutamate-Ammonia Ligase; Glypicans; Haploinsufficiency; HeLa Cells; Hep G2 Cells; Hepacivirus; Hepatitis B virus; HSP70 Heat-Shock Proteins; Humans; Liver Neoplasms; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitosis | 2015 |
Registered report: Intestinal inflammation targets cancer-inducing activity of the microbiota.
Topics: Animals; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colitis; Colorectal Neoplasms; Escherichia coli; Genomic Islands; Interleukin-10; Intestines; Metagenome; Mice, Knockout; Microbiota; Mutation; Polyketide Synthases; Sequence Deletion; Virulence | 2015 |
NPC1L1 knockout protects against colitis-associated tumorigenesis in mice.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azoxymethane; beta Catenin; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Homozygote; Intestinal Mucosa; Lipids; Membrane Transport Proteins; Mice; Mice, Knockout; Transforming Growth Factor beta; Tumor Suppressor Protein p53 | 2015 |
St. John's Wort Attenuates Colorectal Carcinogenesis in Mice through Suppression of Inflammatory Signaling.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Carcinogenesis; Cell Transformation, Neoplastic; Colon; Colorectal Neoplasms; Diet; Dietary Supplements; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Hypericum; Inflammation; Male; Mice; NF-kappa B; Oligonucleotide Array Sequence Analysis; Oligonucleotides; Plant Extracts; Signal Transduction | 2015 |
The MUTYH base excision repair gene protects against inflammation-associated colorectal carcinogenesis.
Topics: Adenocarcinoma; Adenoma; Animals; Azoxymethane; Bone Marrow Cells; CD8-Positive T-Lymphocytes; Cell Transformation, Neoplastic; Colitis; Colon; Colorectal Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; DNA Glycosylases; Forkhead Transcription Factors; Guanine; Inflammation Mediators; Mice, Knockout; T-Lymphocytes, Regulatory; Time Factors | 2015 |
Mast Cells Infiltrating Inflamed or Transformed Gut Alternatively Sustain Mucosal Healing or Tumor Growth.
Topics: Animals; Animals, Congenic; Azoxymethane; Carcinoma; Cell Count; Cell Transformation, Neoplastic; Cells, Cultured; Colitis; Colonic Neoplasms; Dextran Sulfate; Epithelial Cells; Humans; Inflammatory Bowel Diseases; Interleukin-1 Receptor-Like 1 Protein; Interleukin-33; Intestinal Mucosa; Mast Cells; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; Proto-Oncogene Proteins c-kit; Receptors, Interleukin; Regeneration; Serine Endopeptidases; Species Specificity; Specific Pathogen-Free Organisms | 2015 |
The Role of Curcumin in Modulating Colonic Microbiota During Colitis and Colon Cancer Prevention.
Topics: Animals; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colitis; Colon; Colorectal Neoplasms; Curcumin; Dietary Supplements; Disease Models, Animal; Immunity, Mucosal; Intestinal Mucosa; Mice; Mice, 129 Strain; Mice, Knockout; Microbiota | 2015 |
Anthocyanin-containing purple-fleshed potatoes suppress colon tumorigenesis via elimination of colon cancer stem cells.
Topics: Animals; Anthocyanins; Antineoplastic Agents; Apoptosis; Azoxymethane; bcl-2-Associated X Protein; beta Catenin; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Colonic Neoplasms; Cytochromes c; Food; Humans; In Situ Nick-End Labeling; Lentivirus; Male; Mice; Mitochondria; Neoplastic Stem Cells; RNA, Small Interfering; Solanum tuberosum; Sulindac; Tumor Suppressor Protein p53; Wnt Proteins | 2015 |
A hypermorphic epithelial β-catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations.
Topics: Adenomatous Polyps; Animals; Azoxymethane; beta Catenin; Cell Transformation, Neoplastic; Colitis; Colon; Colonic Neoplasms; Colonic Polyps; Cytokines; Gene Expression Regulation, Neoplastic; Genes, APC; Genetic Predisposition to Disease; Heterozygote; Homozygote; Humans; Matrix Metalloproteinase 7; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Neoplasm Staging; Neovascularization, Pathologic; Paneth Cells; Phenotype; Tenascin; Tumor Microenvironment; Wnt Signaling Pathway | 2015 |
Suppression of colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway by balsalazide and VSL#3.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Azoxymethane; bcl-2-Associated X Protein; Cell Transformation, Neoplastic; Colitis; Colon; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Agents; Inflammation Mediators; Interleukin-6; Macrophages; Male; Mesalamine; Mice, Inbred C57BL; Phenylhydrazines; Phosphorylation; Probiotics; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; STAT3 Transcription Factor; Time Factors | 2016 |
PDCD4 Deficiency Aggravated Colitis and Colitis-associated Colorectal Cancer Via Promoting IL-6/STAT3 Pathway in Mice.
Topics: Animals; Apoptosis Regulatory Proteins; Azoxymethane; Blotting, Western; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; Colitis; Colorectal Neoplasms; Cytokines; Female; Immunoenzyme Techniques; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Real-Time Polymerase Chain Reaction; RNA-Binding Proteins; Signal Transduction; STAT3 Transcription Factor | 2016 |
Chronic ethanol feeding promotes azoxymethane and dextran sulfate sodium-induced colonic tumorigenesis potentially by enhancing mucosal inflammation.
Topics: Animals; Azoxymethane; Biomarkers, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Chemokines; Colonic Neoplasms; Cytokines; Dextran Sulfate; Ethanol; Female; Gene Expression; Inflammation; Intestinal Mucosa; Mice; Protein Transport | 2016 |
TNIK inhibition abrogates colorectal cancer stemness.
Topics: Adenomatous Polyposis Coli Protein; Administration, Oral; Aged; Animals; Azoxymethane; beta Catenin; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Colorectal Neoplasms; Crystallography, X-Ray; Female; Germinal Center Kinases; Humans; Imidazoles; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; Middle Aged; Mutation; Neoplastic Stem Cells; Protein Binding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Quinazolines; Recombinant Proteins; Ubiquitin-Protein Ligases; Wnt Proteins; Wnt Signaling Pathway; Xenograft Model Antitumor Assays | 2016 |
A role for the vitamin D pathway in non-intestinal lesions in genetic and carcinogen models of colorectal cancer and in familial adenomatous polyposis.
Topics: Adenocarcinoma; Adenomatous Polyposis Coli; Animals; Azoxymethane; beta Catenin; Cell Transformation, Neoplastic; Colorectal Neoplasms; Disease Models, Animal; Disease Progression; Gardner Syndrome; Genes, APC; Genetic Predisposition to Disease; Mice, Inbred C57BL; Mice, Knockout; Mutation; Phenotype; Polymorphism, Single Nucleotide; Receptors, Calcitriol; Risk Factors; Time Factors; Vitamin D; Wnt Signaling Pathway | 2016 |
Anti-inflammatory natural product goniothalamin reduces colitis-associated and sporadic colorectal tumorigenesis.
Topics: Animals; Anti-Inflammatory Agents; Azoxymethane; Biological Products; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Colitis; Colorectal Neoplasms; Cytokines; Dextran Sulfate; Inflammation; Inflammation Mediators; Macrophages; Mice; Mice, Inbred C57BL; Pyrones | 2017 |
The role of Pygo2 for Wnt/ß-catenin signaling activity during intestinal tumor initiation and progression.
Topics: Adenoma; Animals; Azoxymethane; beta Catenin; Cell Proliferation; Cell Transformation, Neoplastic; Colonic Neoplasms; Disease Models, Animal; Disease Progression; Gene Expression Regulation, Neoplastic; Genes, APC; Genetic Predisposition to Disease; Intracellular Signaling Peptides and Proteins; Mice, Inbred C57BL; Mice, Knockout; Mutation; Phenotype; Proto-Oncogene Proteins c-myc; Time Factors; Tumor Burden; Wnt Signaling Pathway | 2016 |
Daily Intake of High-Fat Diet with Lysophosphatidic Acid-Rich Soybean Phospholipids Augments Colon Tumorigenesis in Kyoto Apc Delta Rats.
Topics: Animals; Azoxymethane; Carcinogenesis; Carcinogens; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Complex Mixtures; Dextran Sulfate; Diet, High-Fat; Disease Models, Animal; Dose-Response Relationship, Drug; Food-Drug Interactions; Glycine max; Intestinal Mucosa; Lysophospholipids; Rats; Statistics as Topic | 2017 |
Exploration of Inflammatory Bowel Disease in Mice: Chemically Induced Murine Models of Inflammatory Bowel Disease (IBD).
Topics: Acute Disease; Animals; Azoxymethane; Cell Transformation, Neoplastic; Chronic Disease; Colitis; Dextran Sulfate; Disease Models, Animal; Humans; Inflammatory Bowel Diseases; Mice; Trinitrobenzenesulfonic Acid | 2017 |
The high affinity peroxisome proliferator-activated receptor-gamma agonist RS5444 inhibits both initiation and progression of colon tumors in azoxymethane-treated mice.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colonic Neoplasms; Disease Progression; Immunohistochemistry; Mice; Mice, Inbred C57BL; PPAR gamma; Thiazolidinediones | 2008 |
Adiponectin suppresses colorectal carcinogenesis under the high-fat diet condition.
Topics: Adiponectin; AMP-Activated Protein Kinase Kinases; Animals; Apoptosis; Azoxymethane; Blotting, Western; Cell Proliferation; Cell Transformation, Neoplastic; Colonic Polyps; Colorectal Neoplasms; Dietary Fats; Intestinal Mucosa; Mice; Mice, Knockout; Obesity; Precancerous Conditions; Protein Biosynthesis; Protein Kinases; Receptors, Adiponectin; TOR Serine-Threonine Kinases | 2008 |
Role for sphingosine kinase 1 in colon carcinogenesis.
Topics: Animals; Azoxymethane; Cell Transformation, Neoplastic; Colonic Neoplasms; Cyclooxygenase 2; Dextran Sulfate; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Inflammation; Lysophospholipids; Mice; Mice, Knockout; Phosphotransferases (Alcohol Group Acceptor); Sphingosine | 2009 |
Protein kinase C betaII and PKCiota/lambda: collaborating partners in colon cancer promotion and progression.
Topics: Adenoma; Animals; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colonic Neoplasms; Disease Progression; Genes, APC; Humans; Isoenzymes; Mice; Mice, Knockout; Mice, Transgenic; Protein Kinase C; Protein Kinase C beta | 2009 |
A gamma-tocopherol-rich mixture of tocopherols inhibits colon inflammation and carcinogenesis in azoxymethane and dextran sulfate sodium-treated mice.
Topics: Adenocarcinoma; Adenoma; Animals; Antioxidants; Apoptosis; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Cocarcinogenesis; Colon; Colonic Neoplasms; Dextran Sulfate; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; gamma-Tocopherol; Inflammation; Leukotriene B4; Male; Mice; Tyrosine | 2009 |
3,3'-diindolylmethane attenuates colonic inflammation and tumorigenesis in mice.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Body Weight; Carcinogens; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Dextran Sulfate; Dinoprostone; Disease Models, Animal; Indoles; Mice; Mice, Inbred BALB C; NF-kappa B; Nitric Oxide; Peroxidase; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Weight Loss | 2009 |
Inhibition of colon carcinogenesis by post-initiation induction of NQO1 in Sprague-Dawley rats.
Topics: Adenoma; Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Enzyme Induction; Glucuronosyltransferase; Glutathione Transferase; Intestinal Mucosa; Male; NAD(P)H Dehydrogenase (Quinone); Neoplasms, Experimental; Precancerous Conditions; Pyrazines; Rats; Rats, Sprague-Dawley; Thiones; Thiophenes; Time Factors | 2009 |
Mucin-depleted foci show strong activation of inflammatory markers in 1,2-dimethylhydrazine-induced carcinogenesis and are promoted by the inflammatory agent sodium dextran sulfate.
Topics: 1,2-Dimethylhydrazine; Animals; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Down-Regulation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Immunohistochemistry; Inflammation; Male; Mucin-2; Nitric Oxide Synthase Type II; Precancerous Conditions; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; Up-Regulation | 2009 |
Long-term ingestion of reduced glutathione suppressed an accelerating effect of beef tallow diet on colon carcinogenesis in rats.
Topics: Animals; Antioxidants; Arachidonic Acid; Azoxymethane; beta Catenin; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Cyclooxygenase 2; Disease Models, Animal; Fats; Glutathione; Glutathione Reductase; Intestinal Mucosa; Male; Oxidative Stress; Precancerous Conditions; Random Allocation; Rats; Rats, Sprague-Dawley | 2009 |
Involvement of JNK pathway in the promotion of the early stage of colorectal carcinogenesis under high-fat dietary conditions.
Topics: Animals; Azoxymethane; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; Colon; Colorectal Neoplasms; Dietary Fats; Disease Models, Animal; Humans; Insulin; Insulin Resistance; Intestinal Mucosa; MAP Kinase Kinase 4; Mice; Mice, Inbred C57BL; Signal Transduction | 2009 |
Co-treatment with deoxycholic acid and azoxymethane accelerates secretion of HMGB1 in IEC6 intestinal epithelial cells.
Topics: Acetylation; Animals; Antibiotics, Antineoplastic; Azoxymethane; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Cholagogues and Choleretics; Colon; Deoxycholic Acid; Enzyme Inhibitors; Epithelial Cells; Fatty Acids, Unsaturated; Histones; HMGB1 Protein; Hydroxamic Acids; Intestinal Mucosa; Male; Rats; Rats, Inbred F344; RNA, Messenger; Up-Regulation | 2009 |
Pla2g2a attenuates colon tumorigenesis in azoxymethane-treated C57BL/6 mice; expression studies reveal Pla2g2a target genes and pathways.
Topics: Animals; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colonic Neoplasms; Disease Models, Animal; Female; Gene Expression Regulation, Neoplastic; Group II Phospholipases A2; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic | 2009 |
Long-term administration of aspirin inhibits tumour formation and triggers anti-neoplastic molecular changes in a pre-clinical model of colon carcinogenesis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Aspirin; Azoxymethane; Carcinogens; Carcinoma; Cell Transformation, Neoplastic; Colonic Neoplasms; Drug Evaluation, Preclinical; Gene Expression Regulation, Neoplastic; Immunity, Innate; Inflammation Mediators; Male; Neoplasms, Experimental; Rats; Rats, Wistar; Time Factors | 2010 |
CD95 is cytoprotective for intestinal epithelial cells in colitis.
Topics: Animals; Azoxymethane; Bone Marrow Transplantation; Carcinogens; Cell Transformation, Neoplastic; Colitis, Ulcerative; Colon; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Fas Ligand Protein; fas Receptor; Intestinal Mucosa; Mice; Mice, Knockout | 2010 |
Expression profiles of proliferative and antiapoptotic genes in sporadic and colitis-related mouse colon cancer models.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Azoxymethane; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Cell Cycle Proteins; Cell Proliferation; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Cyclooxygenase 2; Dextran Sulfate; Disease Models, Animal; Disease Progression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Inhibitor of Apoptosis Proteins; Male; Mice; Mice, Inbred ICR; Microdissection; Microtubule-Associated Proteins; Nitric Oxide Synthase Type II; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-myb; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; Survivin; Telomerase; Transcription Factor 4 | 2010 |
Colitis-associated cancer is dependent on the interplay between the hemostatic and inflammatory systems and supported by integrin alpha(M)beta(2) engagement of fibrinogen.
Topics: Adenoma; Animals; Azoxymethane; Carcinogens; Cell Growth Processes; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Cytokines; Dextran Sulfate; Disease Progression; Fibronectins; Hemostasis; Macrophage-1 Antigen; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic | 2010 |
Identification of gene expression profiles correlated to tumor progression in a preclinical model of colon carcinogenesis.
Topics: Animals; Azoxymethane; Biomarkers, Tumor; Carcinogens; Cell Transformation, Neoplastic; Colonic Neoplasms; Disease Models, Animal; Disease Progression; Gene Expression Profiling; Male; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2010 |
Sex modulates intestinal transformation by the tumor-suppressor GCC.
Topics: Adenomatous Polyposis Coli Protein; Animals; Azoxymethane; Cell Proliferation; Cell Transformation, Neoplastic; Colorectal Neoplasms; Enterocytes; Female; Guanylate Cyclase; Intestines; Male; Mice; Receptors, Enterotoxin; Receptors, Guanylate Cyclase-Coupled; Receptors, Peptide; Sex Characteristics; Tumor Suppressor Proteins | 2008 |
Sex modulates intestinal transformation by the tumor-suppressor GCC.
Topics: Animals; Azoxymethane; Cell Transformation, Neoplastic; Female; Guanylate Cyclase; Intestines; Male; Mice; Receptors, Enterotoxin; Receptors, Guanylate Cyclase-Coupled; Receptors, Peptide; Sex Characteristics; Tumor Suppressor Proteins | 2008 |
Epimorphin deletion protects mice from inflammation-induced colon carcinogenesis and alters stem cell niche myofibroblast secretion.
Topics: Animals; Azoxymethane; Cell Proliferation; Cell Transformation, Neoplastic; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Epithelial Cells; Inflammation; Interleukin-6; Intestinal Mucosa; Mice; Mice, Congenic; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth; Sequence Deletion | 2010 |
Regular exercise reduces colon tumorigenesis associated with suppression of iNOS.
Topics: Animals; Azoxymethane; Body Weight; Cell Transformation, Neoplastic; Citrate (si)-Synthase; Colonic Neoplasms; Cyclooxygenase 2; Male; Mice; Mice, Inbred BALB C; Nitric Oxide Synthase Type II; Physical Conditioning, Animal; Tumor Necrosis Factor-alpha | 2010 |
The NSAID sulindac is chemopreventive in the mouse distal colon but carcinogenic in the proximal colon.
Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Drug Evaluation, Preclinical; Gene Expression Regulation; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation Mediators; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Mice, Knockout; MutS Homolog 2 Protein; Precancerous Conditions; Sulindac; Tumor Suppressor Protein p53 | 2011 |
Western-style diets induce macrophage infiltration and contribute to colitis-associated carcinogenesis.
Topics: Animals; Azoxymethane; beta Catenin; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Dextran Sulfate; Diet; Dinoprostone; Disease Susceptibility; Hydroxyprostaglandin Dehydrogenases; Macrophages; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Signal Transduction; Statistics, Nonparametric; Tumor Necrosis Factor-alpha | 2010 |
MTGR1 is required for tumorigenesis in the murine AOM/DSS colitis-associated carcinoma model.
Topics: Animals; Azoxymethane; Carcinoma; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Disease Progression; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Repressor Proteins | 2011 |
Neo-angiogenesis and the premalignant micro-circulatory augmentation of early colon carcinogenesis.
Topics: Adenoma; Animals; Azoxymethane; Biomarkers, Tumor; Blotting, Western; Carcinogens; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Gene Expression Profiling; Intestinal Mucosa; Neovascularization, Pathologic; Oligonucleotide Array Sequence Analysis; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2011 |
Early lesion formation in colorectal carcinogenesis is associated with adiponectin status whereas neoplastic lesions are associated with diet and sex in C57BL/6J mice.
Topics: Adiponectin; Animals; Azoxymethane; Cell Transformation, Neoplastic; Colon; Colorectal Neoplasms; Dextran Sulfate; Diet; Disease Models, Animal; Female; Gene Expression Regulation; Genotype; Insulin; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptor, Insulin; Receptors, Adiponectin; Risk Factors; Sex Factors; Signal Transduction; Toll-Like Receptor 4 | 2011 |
Low-dose dietary resveratrol has differential effects on colorectal tumorigenesis in adiponectin knockout and wild-type mice.
Topics: Adipocytes; Adiponectin; Animals; Azoxymethane; Caco-2 Cells; Cell Transformation, Neoplastic; Colorectal Neoplasms; Dextran Sulfate; Dietary Fats; Dose-Response Relationship, Drug; Female; Humans; Insulin; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Resveratrol; Sex Factors; Stilbenes; Weight Gain | 2011 |
Microsomal prostaglandin E synthase-1 is involved in multiple steps of colon carcinogenesis.
Topics: Aberrant Crypt Foci; Adenocarcinoma; Animals; Azoxymethane; beta Catenin; Carcinogens; Cell Transformation, Neoplastic; Coculture Techniques; Colonic Neoplasms; Colonic Polyps; Cytokines; Gene Expression Profiling; Intramolecular Oxidoreductases; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Microsomes; Neoplasm Transplantation; Prostaglandin-E Synthases; Prostaglandins | 2012 |
Effects of S-adenosylmethionine and methylthioadenosine on inflammation-induced colon cancer in mice.
Topics: Animals; Apoptosis; Azoxymethane; beta Catenin; Cell Proliferation; Cell Transformation, Neoplastic; Chemoprevention; Colonic Neoplasms; Dextran Sulfate; Inflammation; Interleukin-10; Interleukin-6; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Nitric Oxide Synthase Type II; Proto-Oncogene Proteins c-akt; Purine-Nucleoside Phosphorylase; S-Adenosylhomocysteine; S-Adenosylmethionine; Signal Transduction; STAT3 Transcription Factor; Transcriptional Activation; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2012 |
Glutathione peroxidase-2 and selenium decreased inflammation and tumors in a mouse model of inflammation-associated carcinogenesis whereas sulforaphane effects differed with selenium supply.
Topics: Animals; Apoptosis; Azoxymethane; Cell Transformation, Neoplastic; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Glutathione Peroxidase; Glutathione Transferase; Ileum; Inflammation; Isothiocyanates; Mice; Mice, Inbred C57BL; Mice, Knockout; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Selenium; Sulfoxides; Thiocyanates; Thioredoxin-Disulfide Reductase | 2012 |
Effects of gut-targeted 15-LOX-1 transgene expression on colonic tumorigenesis in mice.
Topics: Animals; Arachidonate 15-Lipoxygenase; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Disease Models, Animal; Epithelial Cells; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Immunoblotting; Intestinal Mucosa; Mice; Mice, Transgenic; NF-kappa B; Nitric Oxide Synthase Type II; Real-Time Polymerase Chain Reaction; RNA, Messenger; Transgenes; Tumor Necrosis Factor-alpha; Up-Regulation | 2012 |
P53 gene mutation increases progastrin dependent colonic proliferation and colon cancer formation in mice.
Topics: Aberrant Crypt Foci; Animals; Azoxymethane; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; Colonic Neoplasms; Disease Models, Animal; Female; Gastrins; Humans; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Protein Precursors; Tumor Suppressor Protein p53 | 2012 |
Silibinin, a natural flavonoid, modulates the early expression of chemoprevention biomarkers in a preclinical model of colon carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Apoptosis; Azoxymethane; Biomarkers, Tumor; Caspase 3; Cell Transformation, Neoplastic; Colonic Neoplasms; Down-Regulation; Interleukin-1beta; Intestinal Mucosa; Male; Matrix Metalloproteinase 7; Plant Extracts; Proto-Oncogene Proteins c-bcl-2; Random Allocation; Rats; Rats, Wistar; RNA, Messenger; Silybin; Silybum marianum; Silymarin; Tumor Necrosis Factor-alpha | 2012 |
Deletion of p38-alpha mitogen-activated protein kinase within the intestinal epithelium promotes colon tumorigenesis.
Topics: Adenoma; Animals; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Enterocytes; Feces; Intestinal Mucosa; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 14; Weight Loss | 2012 |
Intestinal inflammation targets cancer-inducing activity of the microbiota.
Topics: Animals; Azoxymethane; Carcinogens; Carcinoma; Cell Transformation, Neoplastic; Colitis; Colorectal Neoplasms; DNA Damage; Escherichia coli; Interleukin-10; Intestines; Metagenome; Mice; Mice, Mutant Strains; Polyketide Synthases; Sequence Deletion | 2012 |
Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Adenoma; Animals; Animals, Inbred Strains; Azoxymethane; Cell Transformation, Neoplastic; Chemokines, CXC; Colitis; Colonic Neoplasms; Dermatitis, Contact; Dextran Sulfate; Gene Expression; Mice; Mice, 129 Strain; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Papilloma; Peroxidase; Precancerous Conditions; Receptors, Interleukin-8B; Skin Neoplasms; Statistics, Nonparametric; Tetradecanoylphorbol Acetate; Tumor Burden | 2012 |
Mice that express human interleukin-8 have increased mobilization of immature myeloid cells, which exacerbates inflammation and accelerates colon carcinogenesis.
Topics: Animals; Azoxymethane; Cell Line, Tumor; Cell Movement; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Dendritic Cells; Dextran Sulfate; Gastritis; Helicobacter felis; Helicobacter Infections; Humans; Interleukin-8; Lipopolysaccharides; Macrophages; Mice; Mice, Transgenic; Myeloid Cells; Primary Cell Culture; RNA, Messenger; Tumor Burden; Up-Regulation | 2013 |
Tpl2 regulates intestinal myofibroblast HGF release to suppress colitis-associated tumorigenesis.
Topics: Adenocarcinoma; Animals; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colitis; Dextran Sulfate; Hepatocyte Growth Factor; Intestinal Mucosa; Intestinal Neoplasms; Intestines; MAP Kinase Kinase Kinases; Mice; Mice, Knockout; Mucous Membrane; Myofibroblasts; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-met; Signal Transduction | 2012 |
Organomagnesium suppresses inflammation-associated colon carcinogenesis in male Crj: CD-1 mice.
Topics: Adenocarcinoma; Adenoma; Animals; Apoptosis; Azoxymethane; Blotting, Western; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Dextran Sulfate; Humans; Immunoenzyme Techniques; Inflammation; Interferon-gamma; Interleukin-1beta; Interleukin-6; Magnesium Compounds; Male; Mice; Mice, Inbred ICR; Mitotic Index; Organometallic Compounds; Real-Time Polymerase Chain Reaction; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured | 2013 |
Studies on the chemopreventive effect of carnitine on tumorigenesis in vivo, using two experimental murine models of colon cancer.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Carnitine; Carnitine O-Acetyltransferase; Cell Transformation, Neoplastic; Colonic Neoplasms; Diet; Disease Models, Animal; Genes, APC; Intestines; Male; Mice; Mice, Inbred C57BL; Mutation | 2012 |
Vanillin differentially affects azoxymethane-injected rat colon carcinogenesis and gene expression.
Topics: Aberrant Crypt Foci; Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Benzaldehydes; Cell Cycle; Cell Transformation, Neoplastic; Colon; Colorectal Neoplasms; DNA Mismatch Repair; Gene Expression; Male; Mutation; Rats; Rats, Sprague-Dawley | 2012 |
Loss of sulfiredoxin renders mice resistant to azoxymethane/dextran sulfate sodium-induced colon carcinogenesis.
Topics: Animals; Apoptosis; Azoxymethane; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Colonic Neoplasms; Dextran Sulfate; Genotype; Humans; Lung Neoplasms; Macrophages; Mice; Mice, Knockout; Oxidoreductases Acting on Sulfur Group Donors; Peroxiredoxins | 2013 |
Simple sugars modulate the development of aberrant crypt foci in rat colon during post-initiation.
Topics: Animals; Azoxymethane; Carcinogens; Cell Division; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Dextrins; Diet; Dietary Sucrose; Male; Malondialdehyde; Oxidation-Reduction; Precancerous Conditions; Random Allocation; Rats; Rats, Inbred F344; Starch | 2002 |
Parp-1 deficiency implicated in colon and liver tumorigenesis induced by azoxymethane.
Topics: Adenocarcinoma; Adenoma; Animals; Azoxymethane; beta Catenin; Carcinogens; Cell Transformation, Neoplastic; Colonic Neoplasms; Cytoskeletal Proteins; Disease Progression; DNA Primers; Female; Homozygote; Liver Neoplasms, Experimental; Mice; Mice, Inbred ICR; Mice, Knockout; Poly(ADP-ribose) Polymerases; Trans-Activators | 2003 |
Protein kinase Ciota is required for Ras transformation and colon carcinogenesis in vivo.
Topics: Animals; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colonic Neoplasms; Enzyme Activation; Epithelial Cells; Humans; Intestinal Mucosa; Isoenzymes; Mice; Mice, Inbred C57BL; Mice, Transgenic; Protein Kinase C; rac1 GTP-Binding Protein; ras Proteins; Rats; Signal Transduction | 2004 |
Lactoferrin enhances Fas expression and apoptosis in the colon mucosa of azoxymethane-treated rats.
Topics: Animals; Apoptosis; Azoxymethane; Carcinogens; Caspases; Cattle; Cell Transformation, Neoplastic; Chemoprevention; Colon; Colonic Neoplasms; Enzyme Activation; fas Receptor; Immunoenzyme Techniques; Lactoferrin; Male; Proteins; Rats; Rats, Inbred F344; Receptors, Tumor Necrosis Factor | 2004 |
Transforming growth factor beta receptor type II inactivation promotes the establishment and progression of colon cancer.
Topics: Animals; Apoptosis; Azoxymethane; Carcinogens; Carrier Proteins; Cell Differentiation; Cell Division; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Cyclooxygenase 2; Disease Models, Animal; Disease Progression; Fatty Acid-Binding Proteins; Female; Gene Silencing; Genetic Predisposition to Disease; Isoenzymes; Male; Mice; Mutation; Prostaglandin-Endoperoxide Synthases; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta | 2004 |
Lactoferrin modifies apoptosis-related gene expression in the colon of the azoxymethane-treated rat.
Topics: Administration, Oral; Animals; Apoptosis; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Chemoprevention; Colonic Neoplasms; Cyclin D1; Disease Models, Animal; Fas Ligand Protein; Gene Expression Regulation; Lactoferrin; Male; Membrane Glycoproteins; Rats; Rats, Inbred F344; Up-Regulation | 2004 |
Leptin reduces the development of the initial precancerous lesions induced by azoxymethane in the rat colonic mucosa.
Topics: Animals; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colonic Neoplasms; Intestinal Mucosa; Leptin; Obesity; Precancerous Conditions; Rats; Rats, Zucker | 2004 |
Folate transport gene inactivation in mice increases sensitivity to colon carcinogenesis.
Topics: Animals; Azoxymethane; Carcinogens; Carrier Proteins; Cell Cycle; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Folate Receptors, GPI-Anchored; Gene Expression Profiling; Gene Silencing; Genetic Predisposition to Disease; Kidney; Male; Membrane Transport Modulators; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligonucleotide Array Sequence Analysis; Precancerous Conditions; Receptors, Cell Surface; Reduced Folate Carrier Protein; Reverse Transcriptase Polymerase Chain Reaction; S-Adenosylhomocysteine; S-Adenosylmethionine | 2005 |
Modifying effects of Terminalia catappa on azoxymethane-induced colon carcinogenesis in male F344 rats.
Topics: Administration, Oral; Animals; Azoxymethane; Biomarkers, Tumor; Carcinogens; Cell Transformation, Neoplastic; Chemoprevention; Colonic Diseases; Colonic Neoplasms; Male; Phytotherapy; Plant Extracts; Proliferating Cell Nuclear Antigen; Random Allocation; Rats; Rats, Inbred F344; Terminalia | 2005 |
Increased microvascular blood content is an early event in colon carcinogenesis.
Topics: Adenoma; Animals; Azoxymethane; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Disease Models, Animal; Disease Progression; Hemoglobins; Humans; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Microcirculation; Optics and Photonics; Pilot Projects; Precancerous Conditions; Rats; Rats, Inbred F344; Scattering, Radiation | 2005 |
In vivo imaging of colitis and colon cancer development in mice using high resolution chromoendoscopy.
Topics: Animals; Azoxymethane; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Colonoscopes; Colonoscopy; Dextran Sulfate; Disease Models, Animal; Disease Progression; Intestinal Mucosa; Mice; Mice, Inbred Strains; Severity of Illness Index | 2005 |
Inhibitory effect of linoleic acid on transformation of IEC6 intestinal cells by in vitro azoxymethane treatment.
Topics: Animals; Arachidonate 15-Lipoxygenase; Azoxymethane; bcl-2-Associated X Protein; Carcinogens; Cell Transformation, Neoplastic; Cyclooxygenase 2; Cytochrome P-450 CYP2E1; DNA Damage; ErbB Receptors; In Vitro Techniques; Intestinal Mucosa; Ligands; Linoleic Acid; Lipoxygenase Inhibitors; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Oligodeoxyribonucleotides, Antisense; Phosphorylation; PPAR gamma; Rats | 2006 |
Risk stratification of colon carcinogenesis through enhanced backscattering spectroscopy analysis of the uninvolved colonic mucosa.
Topics: Animals; Azoxymethane; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Disease Models, Animal; Disease Progression; Equipment Design; Female; Humans; Light; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Middle Aged; Pilot Projects; Predictive Value of Tests; Radiography; Rats; Rats, Inbred F344; Risk Factors; Scattering, Radiation; Sensitivity and Specificity; Spectrum Analysis | 2006 |
High concentration of deoxycholic acid abrogates in vitro transformation of IEC6 intestinal cells by azoxymethane.
Topics: Animals; Antineoplastic Agents; Apoptosis; Azoxymethane; Carcinogens; Cell Line; Cell Proliferation; Cell Transformation, Neoplastic; Comet Assay; Cytochrome P-450 CYP2E1; Deoxycholic Acid; In Vitro Techniques; Mice; Mice, Nude; Neoplasms, Experimental; Rats | 2005 |
Long-term feeding of various fat diets modulates azoxymethane-induced colon carcinogenesis through Wnt/beta-catenin signaling in rats.
Topics: Animals; Apoptosis; Azoxymethane; beta Catenin; Cell Proliferation; Cell Transformation, Neoplastic; Colonic Neoplasms; Corn Oil; Cyclin D; Cyclins; Dietary Fats; Disease Models, Animal; Fats; Fish Oils; Male; Olive Oil; Plant Oils; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Signal Transduction; Time Factors; Wnt Proteins | 2007 |
Epidermal growth factor receptor signaling is required for microadenoma formation in the mouse azoxymethane model of colonic carcinogenesis.
Topics: Adenoma; Animals; Azoxymethane; beta Catenin; Carcinogens; Cell Transformation, Neoplastic; Colonic Neoplasms; Cyclin D1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; ErbB Receptors; Gefitinib; Genes, ras; Male; Mice; Mice, Inbred A; Mutation; Quinazolines; Signal Transduction; Up-Regulation | 2007 |
Guanylyl cyclase C suppresses intestinal tumorigenesis by restricting proliferation and maintaining genomic integrity.
Topics: Animals; Apoptosis; Azoxymethane; beta Catenin; Cell Cycle Proteins; Cell Proliferation; Cell Transformation, Neoplastic; Colonic Neoplasms; Disease Models, Animal; DNA Damage; Gene Expression Regulation, Neoplastic; Genes, APC; Guanylate Cyclase; Intestinal Neoplasms; Intestine, Small; Ki-67 Antigen; Loss of Heterozygosity; Mice; Mice, Knockout; Mutation; Receptors, Enterotoxin; Receptors, Guanylate Cyclase-Coupled; Receptors, Peptide | 2007 |
Development of normal human colon cell cultures to identify priority unregulated disinfection by-products with a carcinogenic potential.
Topics: Acetates; Azoxymethane; Carcinogens; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Colon; Cytochrome P-450 Enzyme System; Glutathione Transferase; Humans; Hydrocarbons, Brominated; Inhibitory Concentration 50; Time Factors; Trihalomethanes | 2007 |
Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis.
Topics: Animals; Azoxymethane; Carcinoma; Cell Transformation, Neoplastic; Chronic Disease; Colitis, Ulcerative; Colonic Neoplasms; Dextran Sulfate; Disease Models, Animal; Etanercept; Immunoglobulin G; Mice; Mice, Mutant Strains; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Tumor Necrosis Factor Decoy Receptors; Tumor Necrosis Factor-alpha | 2008 |
Lack of interleukin-4 receptor alpha chain-dependent signalling promotes azoxymethane-induced colorectal aberrant crypt focus formation in Balb/c mice.
Topics: Animals; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colorectal Neoplasms; Disease Models, Animal; Female; Interleukin-13; Interleukin-4; Intestinal Mucosa; Mice; Mice, Inbred BALB C; Mice, Knockout; Precancerous Conditions; Receptors, Cell Surface; Signal Transduction; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha | 2008 |
Dietary soy protein inhibits DNA damage and cell survival of colon epithelial cells through attenuated expression of fatty acid synthase.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Caco-2 Cells; Carcinogens; Caseins; Cell Transformation, Neoplastic; Cerulenin; Colon; Dietary Proteins; DNA Damage; Down-Regulation; Epithelial Cells; Fatty Acid Synthase, Type I; Fatty Acid Synthases; Fatty Acid Synthesis Inhibitors; Female; Humans; Hydrocarbons, Fluorinated; Insulin; Male; Methylnitrosourea; Phosphorylation; Rats; Rats, Sprague-Dawley; RNA Interference; RNA, Small Interfering; Soybean Proteins; Sulfonamides; Transfection; Tumor Suppressor Protein p53 | 2008 |
Peroxisome proliferator-activated receptor gamma (PPARgamma) suppresses colonic epithelial cell turnover and colon carcinogenesis through inhibition of the beta-catenin/T cell factor (TCF) pathway.
Topics: Active Transport, Cell Nucleus; Animals; Azoxymethane; beta Catenin; Caco-2 Cells; Cell Proliferation; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Epithelial Cells; Female; HT29 Cells; Humans; Mice; Mice, Inbred BALB C; Mice, Knockout; Pioglitazone; PPAR gamma; Protein Binding; RNA Interference; Signal Transduction; TCF Transcription Factors; Thiazolidinediones; Time Factors; Transfection | 2008 |
Genetic ablation of M3 muscarinic receptors attenuates murine colon epithelial cell proliferation and neoplasia.
Topics: Animals; Azoxymethane; Cell Proliferation; Cell Transformation, Neoplastic; Colonic Neoplasms; Epithelial Cells; Gene Expression Regulation, Neoplastic; Humans; In Situ Hybridization; Mice; Mice, Transgenic; Models, Biological; Models, Genetic; Receptor, Muscarinic M3; Signal Transduction | 2008 |
Human colon cells: culture and in vitro transformation.
Topics: Antigens, Viral, Tumor; Azoxymethane; Cell Transformation, Neoplastic; Cells, Cultured; Colon; Colonic Neoplasms; Fibroblasts; Humans; Lectins; Simian virus 40 | 1984 |
1 alpha,25-Dihydroxy-16-ene-23-yne-26,27-hexafluorocholecalciferol, a noncalcemic analogue of 1 alpha,25-dihydroxyvitamin D3, inhibits azoxymethane-induced colonic tumorigenesis.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Calcitriol; Cell Transformation, Neoplastic; Colonic Neoplasms; Male; Rats; Rats, Inbred F344 | 1995 |
Selective preservation of protein kinase C-zeta in the chemoprevention of azoxymethane-induced colonic tumors by piroxicam.
Topics: Administration, Oral; Animals; Azoxymethane; Cell Transformation, Neoplastic; Colonic Neoplasms; Enzyme Induction; Gene Expression Regulation, Neoplastic; Male; Neoplasm Proteins; Piroxicam; Protein Kinase C; Rats; Rats, Inbred F344; Signal Transduction | 1995 |
The effect of bile acids and piroxicam on MHC antigen expression in rat colonocytes during colon cancer development.
Topics: Animals; Azoxymethane; Bile Acids and Salts; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Histocompatibility Antigens; Male; Piroxicam; Rats; Rats, Inbred F344 | 1994 |
Initiated stem cells in murine intestinal carcinogenesis: prolonged survival, control by NK cells, and progression.
Topics: 1,2-Dimethylhydrazine; Animals; Azoxymethane; Brunner Glands; Cell Survival; Cell Transformation, Neoplastic; Dimethylhydrazines; Duodenal Neoplasms; G(M1) Ganglioside; Hyperplasia; Killer Cells, Natural; Male; Mice; Mice, Inbred Strains; Mitosis; Neoplastic Stem Cells; Poly I-C | 1994 |
Mutations of the Apc gene in experimental colorectal carcinogenesis induced by azoxymethane in F344 rats.
Topics: Adenocarcinoma; Adenoma; Animals; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colorectal Neoplasms; DNA, Neoplasm; Epithelium; Genes, APC; Intestinal Mucosa; Male; Mutation; Polymerase Chain Reaction; Precancerous Conditions; Rats; Rats, Inbred F344 | 1998 |
Chemopreventive efficacy of sulindac sulfone against colon cancer depends on time of administration during carcinogenic process.
Topics: Adenocarcinoma; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Carcinogens; Cell Transformation, Neoplastic; Colonic Neoplasms; Cyclooxygenase Inhibitors; Disease Progression; Dose-Response Relationship, Drug; Drug Administration Schedule; Male; Neoplasm Invasiveness; Rats; Rats, Inbred F344; Sulindac; Weight Gain | 1999 |
Inhibition of azoxymethane-induced rat colon carcinogenesis by potassium hydrogen D-glucarate.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Cell Transformation, Neoplastic; Colonic Neoplasms; Glucaric Acid; Male; Rats; Rats, Inbred F344 | 2000 |
Obesity potentiates AOM-induced colon cancer.
Topics: Adenocarcinoma; Animals; Azoxymethane; Cell Transformation, Neoplastic; Colonic Neoplasms; Diet, Fat-Restricted; Intestinal Mucosa; Male; Obesity; Rats; Rats, Zucker; Risk Factors | 2000 |
Inhibition by putrescine of experimental carcinogenesis in rat colon induced by azoxymethane.
Topics: Adenocarcinoma; Adenoma; Animals; Azoxymethane; Body Weight; Carcinoma in Situ; Cell Transformation, Neoplastic; Colonic Neoplasms; Male; Ornithine Decarboxylase; Putrescine; Rats; Rats, Inbred Strains | 1991 |
The effect of experimental carcinogenesis on intestinal diamine oxidase, a polyamine deaminating enzyme.
Topics: Amine Oxidase (Copper-Containing); Animals; Azo Compounds; Azoxymethane; Cecum; Cell Division; Cell Transformation, Neoplastic; Colon; Duodenum; Ileum; Intestinal Mucosa; Intestinal Neoplasms; Intestines; Jejunum; Kinetics; Male; Rats; Rats, Inbred F344; Rectum; Time Factors | 1986 |
Changes in crypt cell DNA content during experimental colonic carcinogenesis.
Topics: Animals; Azoxymethane; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; DNA; Intestinal Mucosa; Male; Precancerous Conditions; Rats; Rats, Inbred Strains | 1986 |
Elevated plasma enteroglucagon alone fails to alter distal colonic carcinogenesis in rats.
Topics: Animals; Azoxymethane; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Gastrointestinal Hormones; Glucagon-Like Peptides; Jejunoileal Bypass; Male; Organ Size; Rats; Rats, Inbred Strains | 1987 |