Page last updated: 2024-10-23

azosemide and Heart Failure

azosemide has been researched along with Heart Failure in 12 studies

azosemide : A sulfonamide that is benzenesulfonamide which is substituted at positions 2, 4, and 5 by chlorine, (2-thienylmethyl)amino and 1H-tetrazol-5-yl groups, respectively. It is a diuretic that has been used in the management of oedema and hypertension.

Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.

Research Excerpts

ExcerptRelevanceReference
"To assess the efficacy and safety of azosemide in patients with edema and ascites."9.11[Efficacy and safety of azosemide in patients with edema and ascites]. ( Chen, JZ; Hu, XS; Hu, YL; Huang, GZ; Huang, XS; Lin, WQ; Wu, ZG; Zhang, Y; Zheng, JC, 2005)
"A long-acting loop diuretic, azosemide, has been shown to improve long-term prognosis in patients with heart failure compared with a short-acting loop diuretic, furosemide."7.91Patients With CONgestive Heart Failure Benefit From Long-Term Treatment Effects With Novel Treatment Using Azosemide Compared With Furosemide Derived From Existing Retrospective Study Data: CONTENTED. ( Abe, S; Arikawa, T; Inami, S; Inoue, T; Kanaya, T; Nishikawa, R; Saito, F; Sakuma, M; Toyoda, S; Watanabe, R, 2019)
"We have previously reported that a long-acting loop diuretic, azosemide, reduces cardiovascular risks in patients with chronic heart failure (CHF) as compared with a short-acting one, furosemide, in Japanese Multicenter Evaluation of LOng- versus short-acting Diuretics In Congestive heart failure (J-MELODIC)."5.24Changes in brain natriuretic peptide in chronic heart failure patients treated with long-acting versus short-acting loop diuretics: J-MELODIC subanalysis. ( Akasaka, T; Daimon, T; Fukui, M; Hirano, Y; Hirotani, S; Ito, H; Kawabata, M; Masuyama, T; Nakatani, S; Ohte, N; Tsujino, T; Yamamoto, K, 2017)
"To assess the efficacy and safety of azosemide in patients with edema and ascites."5.11[Efficacy and safety of azosemide in patients with edema and ascites]. ( Chen, JZ; Hu, XS; Hu, YL; Huang, GZ; Huang, XS; Lin, WQ; Wu, ZG; Zhang, Y; Zheng, JC, 2005)
"We investigated the effects of a short-acting loop diuretic (furosemide) and a long-acting loop diuretic (azosemide) on heart rate variability, fluid balance, and neurohormonal responses in patients with mild to moderate chronic congestive heart failure."5.09Effects of short-acting and long-acting loop diuretics on heart rate variability in patients with chronic compensated congestive heart failure. ( Doba, N; Imai, Y; Nakayama, T; Sakuma, Y; Shiojima, K; Tomiyama, H; Watanabe, G; Yamamoto, A; Yoshida, H, 1999)
"A long-acting loop diuretic, azosemide, has been shown to improve long-term prognosis in patients with heart failure compared with a short-acting loop diuretic, furosemide."3.91Patients With CONgestive Heart Failure Benefit From Long-Term Treatment Effects With Novel Treatment Using Azosemide Compared With Furosemide Derived From Existing Retrospective Study Data: CONTENTED. ( Abe, S; Arikawa, T; Inami, S; Inoue, T; Kanaya, T; Nishikawa, R; Saito, F; Sakuma, M; Toyoda, S; Watanabe, R, 2019)
"We compared therapeutic effects of furosemide, a short-acting loop diuretic, and azosemide, a long-acting one, in hypertensive heart failure rats to test the hypothesis that long-acting diuretics are superior to short-acting types in heart failure."3.73Different effects of long- and short-acting loop diuretics on survival rate in Dahl high-salt heart failure model rats. ( Hori, M; Mano, T; Masuyama, T; Miwa, T; Nishio, M; Ohtani, T; Sakata, Y; Yamamoto, K; Yoshida, J, 2005)
"We evaluated the comparative effects of furosemide, a short-acting loop diuretic, and azosemide, a long-acting loop diuretic, on neurohumoral factors and quality of life (QOL) in patients with congestive heart failure (CHF)."3.71Comparison of neurohumoral effects of short-acting and long-acting loop diuretics in patients with chronic congestive heart failure. ( Kinoshita, M; Maeda, K; Tsutamoto, T; Tsutsui, T, 2001)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (8.33)18.2507
2000's5 (41.67)29.6817
2010's6 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kitada, S1
Kikuchi, S1
Tsujino, T3
Masuyama, T4
Ohte, N3
Toyoda, S1
Arikawa, T1
Inami, S1
Nishikawa, R1
Saito, F1
Watanabe, R1
Sakuma, M1
Kanaya, T1
Abe, S1
Inoue, T1
Fukui, M1
Hirotani, S1
Ito, H2
Yamamoto, K3
Akasaka, T2
Hirano, Y2
Daimon, T2
Nakatani, S2
Kawabata, M1
Harada, K1
Izawa, H1
Nishizawa, T1
Hirashiki, A1
Murase, Y1
Kobayashi, M1
Isobe, S1
Cheng, XW1
Noda, A1
Nagata, K1
Yokota, M1
Murohara, T1
Hisatake, S1
Nanjo, S1
Fujimoto, S1
Yamashina, S1
Yuzawa, H1
Namiki, A1
Nakano, H1
Yamazaki, J1
Miyata, M1
Sasaki, T1
Ikeda, Y1
Shinsato, T1
Kubozono, T1
Furusho, Y1
Kusumoto, A1
Hamasaki, S1
Tei, C1
Origasa, H1
Yoshida, J1
Mano, T1
Sakata, Y1
Nishio, M1
Ohtani, T1
Hori, M1
Miwa, T1
Zhang, Y1
Hu, XS1
Chen, JZ1
Wu, ZG1
Huang, GZ1
Hu, YL1
Huang, XS1
Lin, WQ1
Zheng, JC1
Tomiyama, H1
Nakayama, T1
Watanabe, G1
Shiojima, K1
Sakuma, Y1
Yamamoto, A1
Imai, Y1
Yoshida, H1
Doba, N1
Tsutsui, T1
Tsutamoto, T1
Maeda, K1
Kinoshita, M1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Japanese Multicenter Evaluation of Long- Versus Short-acting Diuretics in Congestive Heart Failure[NCT00355667]Phase 4320 participants (Actual)Interventional2006-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

9 trials available for azosemide and Heart Failure

ArticleYear
The prognostic value of brain natriuretic peptide in patients with heart failure and left ventricular ejection fraction higher than 60%: a sub-analysis of the J-MELODIC study.
    ESC heart failure, 2018, Volume: 5, Issue:1

    Topics: Aged; Biomarkers; Cardiac Catheterization; Female; Follow-Up Studies; Heart Failure; Heart Ventricle

2018
Changes in brain natriuretic peptide in chronic heart failure patients treated with long-acting versus short-acting loop diuretics: J-MELODIC subanalysis.
    Heart and vessels, 2017, Volume: 32, Issue:7

    Topics: Aged; Aged, 80 and over; Biomarkers; Chronic Disease; Echocardiography; Female; Furosemide; Heart Fa

2017
Beneficial effects of torasemide on systolic wall stress and sympathetic nervous activity in asymptomatic or mildly symptomatic patients with heart failure: comparison with azosemide.
    Journal of cardiovascular pharmacology, 2009, Volume: 53, Issue:6

    Topics: Administration, Oral; Aldosterone; Cross-Over Studies; Delayed-Action Preparations; Drug Administrat

2009
Comparative analysis of the therapeutic effects of long-acting and short-acting loop diuretics in the treatment of chronic heart failure using (123)I-metaiodobenzylguanidine scintigraphy.
    European journal of heart failure, 2011, Volume: 13, Issue:8

    Topics: 3-Iodobenzylguanidine; Adult; Aged; Aged, 80 and over; Chronic Disease; Cross-Over Studies; Female;

2011
Comparative study of therapeutic effects of short- and long-acting loop diuretics in outpatients with chronic heart failure (COLD-CHF).
    Journal of cardiology, 2012, Volume: 59, Issue:3

    Topics: Aged; Atrial Natriuretic Factor; Biomarkers; Chronic Disease; Delayed-Action Preparations; Echocardi

2012
Superiority of long-acting to short-acting loop diuretics in the treatment of congestive heart failure.
    Circulation journal : official journal of the Japanese Circulation Society, 2012, Volume: 76, Issue:4

    Topics: Aged; Aged, 80 and over; Chi-Square Distribution; Chronic Disease; Disease-Free Survival; Female; Fu

2012
[Efficacy and safety of azosemide in patients with edema and ascites].
    Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2005, Volume: 34, Issue:5

    Topics: Adolescent; Adult; Aged; Ascites; Diuretics; Double-Blind Method; Edema; Edema, Cardiac; Female; Hea

2005
Rationale and design of a randomized trial to assess the effects of diuretics in heart failure: Japanese Multicenter Evaluation of Long- vs Short-Acting Diuretics in Congestive Heart Failure (J-MELODIC).
    Circulation journal : official journal of the Japanese Circulation Society, 2007, Volume: 71, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Delayed-Action Preparations; Diuretics; Furosemide; Heart Failure; H

2007
Effects of short-acting and long-acting loop diuretics on heart rate variability in patients with chronic compensated congestive heart failure.
    American heart journal, 1999, Volume: 137, Issue:3

    Topics: Blood Pressure; Cardiac Output; Chronic Disease; Cross-Over Studies; Diuretics; Echocardiography, Do

1999

Other Studies

3 other studies available for azosemide and Heart Failure

ArticleYear
Patients With CONgestive Heart Failure Benefit From Long-Term Treatment Effects With Novel Treatment Using Azosemide Compared With Furosemide Derived From Existing Retrospective Study Data: CONTENTED.
    Journal of cardiovascular pharmacology, 2019, Volume: 73, Issue:6

    Topics: Aged; Aged, 80 and over; Disease Progression; Female; Furosemide; Glomerular Filtration Rate; Heart

2019
Different effects of long- and short-acting loop diuretics on survival rate in Dahl high-salt heart failure model rats.
    Cardiovascular research, 2005, Oct-01, Volume: 68, Issue:1

    Topics: Animals; Echocardiography; Furosemide; Heart Failure; Interleukin-1; Norepinephrine; Rats; Rats, Inb

2005
Comparison of neurohumoral effects of short-acting and long-acting loop diuretics in patients with chronic congestive heart failure.
    Journal of cardiovascular pharmacology, 2001, Volume: 38 Suppl 1

    Topics: Administration, Oral; Aged; Chi-Square Distribution; Chronic Disease; Diuretics; Dosage Forms; Femal

2001