Compounds > azomycin
Page last updated: 2024-08-21

azomycin and Parasitemia

azomycin has been researched along with Parasitemia in 97 studies

Research

Studies (97)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (4.12)18.2507
2000's15 (15.46)29.6817
2010's58 (59.79)24.3611
2020's20 (20.62)2.80

Authors

AuthorsStudies
Brancaglion, GA; Caldas, IS; Caldas, S; Carvalho, DT; Diniz, LF; Gonçalves-Santos, E; Mazzeti, AL; Novaes, RD; Oliveira, RRG; Silva, LS; Vilas-Boas, DF1
Barbosa, JMC; Cascabulho, CM; Daliry, A; de Melo, TG; de Oliveira, G; Pedra Rezende, Y; Pereira, ENGDS; Salem, KS1
Altcheh, J; Ballering, G; Berenstein, AJ; Falk, N; Freilij, H; González, N; Moroni, S; Moscatelli, G1
Altcheh, J; Bisio, MMC; García-Bournissen, F; Gulin, JEN; Rocco, D; Solana, ME1
Marín, C; Martín-Escolano, R; Rosales, MJ1
Altcheh, J; Ballering, G; Bochoeyer, A; Chatelain, E; Falk, N; Freilij, H; Garcia Bournissen, F; Goldsman, A; González, NL; Grippo, M; Jurado, L; Moroni, S; Moscatelli, G1
Assmann, CE; Bottari, NB; Castro, MFV; Chitolina Schetinger, MR; da Rocha, MIUM; da Silva, AS; da Veiga, ML; de Souza, LAF; Dutra da Silva, A; Ferreira, DASP; Fracasso, M; Gundel, S; Monteiro, SG; Morsch, VM; Ourique, AF; Reichert, KP1
Caldas, IS; Chagas-Paula, DA; Diniz, LF; Fernandes, VHC; Gonçalves-Santos, E; Mazzeti, AL; Novaes, RD; Oliveira, CM; Rodrigues, MR; Veloso, MP; Vilas-Boas, DF1
Díaz, ML; Echeverría, LE; Eduardo Nieto, J; González, CI; Hernandez, JCM; López-Romero, LA; Morillo, CA; Ochoa, SAG; Rivera, JD; Rojas, LZ; Suárez, EU1
Cascabulho, CM; Castro, SL; Demarque, KC; Duque, TLA; Guimarães, ACR; Manso, PPA; Menna-Barreto, RF; Meuser-Batista, M; Moura, KCG; Oliveira, GM; Pelajo-Machado, M; Pinto, MDC1
Bermúdez, JM; Cid, AG; Davies, C; Micheloud, JF; Negrette, OS; Parada, LA; Ragone, PG; Simonazzi, A1
Bahia, MT; Caldas, IS; Diniz, LF; Machado, YA; Marques, MJ; Martins-Filho, OA; Mazzeti, AL; Novaes, RD; Santos, LJS; Vilas Boas, BR1
Caldas, IS; Diniz, LF; Gonçalves, RV; Gonçalves-Santos, E; González-Lozano, KJ; Mendonça, AAS; Novaes, RD; Souza-Silva, TG1
Arán, VJ; Batista, DDGJ; Batista, MM; Cumella, J; da Silva, CF; de Oliveira, GM; Escario, JA; Fonseca-Berzal, C; Gómez-Barrio, A; Peres, RB; Silva da Gama Nefertiti, A; Soeiro, MNC1
Altcheh, J; Eagleson, MA; García-Bournissen, F; Gulin, JEN; López-Muñoz, RA; Solana, ME1
Branquinho, RT; de Lana, M; Milagre, MM; Reis, LES; Silva, GN; Silva, RR; Silva, TM; Torchelsen, FKVDS1
Gonzalez Garay, AG; Martinez Garcia, M; Reyes, PP; Vallejo, M1
Batista, LR; Correia, D; da Silva, DAA; da Silva, MV; de Resende, LAPR; de Sousa, RC; Helmo, FR; Lages-Silva, E; Llaguno, M; Machado, JR; Oliveira, CJF; Rodrigues, DBR; Rodrigues, V1
Aoki, MP; Eberhardt, N; García, MC; Jimenez-Kairuz, AF; Ponce, NE; Sanmarco, LM1
Abegg, CP; de Abreu, AP; Fernandes, NS; Gomes, ML; Sarto, MPM; Teston, APM; Toledo, MJO1
Bern, C; Cabeza, J; Castro, R; Clark, T; Gilman, RH; Lora, MH; Lozano, D; Mejia, C; Pajuelo, MJ; Reimer-McAtee, MJ; Terle, J; Torrico, F; Valencia, E1
Alonso, V; Leonardi, D; Real, D; Rocha, SC; Salomon, CJ; Santos Souza, HF; Serra, E; Silber, AM1
Kian, D; Massago, M; Toledo, MJO; Zanusso Junior, G1
Busch, MP; Caillaudeau, J; Cardoso, CS; de Oliveira, LC; Ferreira, AM; Granjon, E; Gueyffier, L; Lee, TH; Liehl, P; Oliveira, CDL; Pottel, H; Ribeiro, ALP; Sabino, EC; Zrein, M1
Altcheh, J; Bisio, M; García-Bournissen, F; Gulin, JEN; Rocco, DM; Solana, ME1
Báez, AL; Bazán, PC; Bustamante, JM; Lo Presti, MS; Nakamura, CV; Paglini-Oliva, P; Rivarola, HW; Rodrigues, JHS; Strauss, M1
Batlle, A; Demaria, A; Frank, FM; Lombardo, ME; Puente, V1
Albareda, MC; Alvarez, MG; Bua, J; Castro Eiro, MD; Cooley, G; De Rissio, AM; Fernandez, M; Fichera, LE; Laucella, SA; Lococo, B; Natale, MA; Nuñez, M; Scollo, K; Serjan, A; Shen, H; Tarleton, RL; Viotti, R1
Bahia, MT; Caldas, IS; Caldas, S; Diniz, LF; Menezes, APJ; Nascimento, ÁFDSD; Novaes, RD1
Bezerra, FS; Costa, GP; Figueiredo, VP; Horta, AL; Leite, ALJ; Menezes, APJ; Pedrosa, TCF; Ramos, CO; Talvani, A; Vieira, PMA1
Bierrenbach, AL; Busch, MP; Cardoso, CS; Colosimo, EA; Ferreira, AM; Ferreira, JE; Lee, TH; Oliveira, CDL; Oliveira, LC; Reingold, AL; Ribeiro, ALP; Sabino, EC; Silva, JLP1
Bastos, TM; Efstathiou, A; Gaboriaud-Kolar, N; Meira, CS; Rocha, VPC; Skaltsounis, AL; Smirlis, D; Soares, MBP; Vougogiannopoulou, K1
Brandão Peres, R; Britto, C; Cristina Demarque, K; da Cruz Moreira, O; de Melo Oliveira, G; de Nazaré Correia Soeiro, M; Diego de Souza Campos, J; Finamore Araújo, P; França da Silva, C; Lima da Costa, K; Machado Cascabulho, C; Meuser Batista, M; Nefertiti da Gama, A; Rocha Simões-Silva, M1
Gonçalves, RV; Maldonado, IRSC; Mendonça, AAS; Natali, AJ; Novaes, RD; Souza-Silva, TG; Talvani, A1
Carneiro, CM; Cunha, ELA; Cunha, LM; de Lana, M; de Oliveira, MT; Fonseca, KDS; Torchelsen, FKVDS; Vieira, PMA1
Gonçalves, RV; Maldonado, IRSC; Natali, AJ; Novaes, RD; Santos, EC; Santos, EG; Souza-Silva, TG; Talvani, A1
Baez, A; Bazán, PC; Cremonezzi, D; Esteves, B; Fauro, R; Lo Presti, MS; Paglini-Oliva, PA; Rivarola, HW; Sanchez Negrete, O; Strauss, M1
Cunha, WR; da Silva Ferreira, D; de Albuquerque, S; do Prado Júnior, JC; e Silva, ML; Esperandim, VR; Kuehn, CC; Toldo, MP1
Bustamante, JM; Craft, JM; Crowe, BD; Ketchie, SA; Tarleton, RL1
Bahia, MT; Caldas, IS; de Andrade, IM; Diniz, Lde F; Martins, TA; Mazzeti, AL; Ribeiro, I; Talvani, A; Urbina, JA1
Bucheton, B; Courtois, P; Cuny, G; Daulouède, S; Dethoua, M; Nzoumbou-Boko, R; Semballa, S; Truc, P; Vincendeau, P1
Beaulieu, C; Black, WC; Isabel, E; Massé, F; Mellon, C; Methot, N; Nath-Chowdhury, M; Ndao, M; Nicoll-Griffith, DA; Vasquez-Camargo, F1
Bakunov, SA; Bakunova, SM; Batista, MM; da Silva, CF; da Silva, FH; da Silva, PB; Jones, SK; Patrick, DA; Soeiro, Mde N; Tidwell, RR; Timm, BL1
Arán, VJ; Escario, JA; Fonseca-Berzal, C; Gómez-Barrio, A; Palmeiro-Roldán, R; Torrado-Durán, S; Torrado-Santiago, S1
Carneiro, ZA; da Silva, RS; Milanezi, C; Santos, M; Sesti-Costa, R; Silva, GK; Silva, JS; Silva, MC1
Araújo, MS; Carneiro, CM; Lana, Md; Machado-de-Assis, GF; Martins, HR; Martins-Filho, OA; Oliveira, MT; Oliveira-Silva, JC; Paiva, NC1
Araújo, SM; Barbosa, Md; Gomes, ML; Gruendling, AP; Kaneshima, EN; Massago, M; Monteiro, WM; Teston, AP; Toledo, MJ1
Anibal, Fde F; Costa, FC; da Silva, MT; de Lima, GM; Portapilla, GB; Silva-Jardim, I; Thiemann, OH1
Marín, C; Martín-Escolano, R; Olmo, F; Rosales, MJ; Sánchez-Moreno, M; Urbanová, K1
Glynne, R; Groessl, T; Khare, S; Liu, X; Molteni, V; Rivera, I; Stinson, M; Supek, F; Tuntland, T; Wen, B; Yeh, V1
Cifuente, D; Lozano, E; Rivarola, HW; Sosa, MA; Spina, R; Strauss, M; Tonn, C1
Batista, DG; Britto, C; da Silva, CF; de Araújo, JS; Ferreira, CG; Guedes-da-Silva, FH; Lepesheva, GI; Meuser, MB; Moreira, OC; Simões-Silva, MR; Soeiro, Mde N1
Ciapponi, A; Comandé, D; Cuesta, CB; Hicks, E; Roberts, KN; Sguassero, Y; Sosa-Estani, S1
Angheben, A; Aprili, G; Bisoffi, Z; Boix, L; Buonfrate, D; Gandini, G; Gobbi, F; Pupella, S1
Coelho, PL; de Oliveira Cardoso, MV; de Oliveira Filho, GB; de Simone, CA; Espíndola, JW; Ferreira, LF; Ferreira, RS; Lima Leite, AC; Magalhaes Moreira, DR; Meira, CS; Soares, MB1
Araújo, JS; Bakunov, SA; Bakunova, SM; Batista, DG; Britto, C; Da Silva, CF; Da Silva, PB; Demarque, KC; Fulco, TO; Guedes-da-Silva, FH; Meuser, MB; Moreira, OC; Oliveira, GM; Patrick, DA; Soeiro, MN; Tidwell, RR1
Cevey, ÁC; Goren, NB; Mirkin, GA; Penas, FN1
Caldas, IS; Gonçalves, RV; Novaes, RD; Rodrigues, JP; Santos, EC; Sartini, MV; Souza, RL1
Aoki, MP; García, MC; Jimenez-Kairuz, AF; Manzo, RH; Ponce, NE; Sanmarco, LM1
Arrúa, EC; Esteva, MI; Fichera, LE; Rial, MS; Salomon, CJ; Scalise, ML1
Campos-Estrada, C; Castro, L; Cortes, L; Díaz, MV; Kemmerling, U; Lapier, M; López-Muñoz, R; Maya, JD; Miranda, MR; Morello, A; Pereira, CA; Reigada, C; Seguel, V1
Castillo, C; Cramer, A; González-Herrera, F; Kemmerling, U; Liempi, A; Machado, FS; Maya, JD; Pimentel, P1
Carrilero, B; Murcia, L; Roig, M; Segovia, M; Simón, M1
Bahia, MT; Bloomer, WD; Gonçalves, KR; Mazzeti, AL; Mendes, PF; Papadopoulou, MV; Rosenzweig, HS1
Arantes, JM; Bahia, MT; Carneiro, CM; de Abreu Vieira, PM; de Lana, M; Francisco, AF; Martins, HR; Pedrosa, ML; Silva, M; Tafuri, WL; Veloso, VM1
Bahia, MT; Caldas, S; Crepalde, GP; de Assis Cáu, SB; de Lana, M; Dos Santos, FM; Machado-Coelho, GL; Veloso, VM1
Balbinot, MM; Fernandes, CD; Liarte, DB; Romanha, A; Scholl, D; Steindel, M; Tiecher, FM1
Alba Soto, CD; Fernández, MC; González Cappa, SM; Poncini, CV; Postan, M; Solana, ME1
Fernández, MC; González Cappa, SM; Solana, ME1
Bahia, MT; Caldas, IS; Carneiro, CM; Diniz, LF; Lana, M; Machado-Coelho, GL; Martins, TA; Oliveira, Rde P; Santos, DM; Talvani, A1
Brutus, L; Chippaux, JP; Clavijo, AN; Postigo, JR; Santalla, JA; Schneider, D1
Bendhack, LM; da Silva, GK; da Silva, RS; Do Valle Matta, MA; Franco, DW; Guedes, PM; Gutierrez, FR; Oliveira, FS; Rodrigues, GJ; Silva, JS; Zamboni, DS1
Albuquerque, S; do Prado, JC; Kuehn, CC; Loria, RM; Oliveira, LG; Santos, CD; Toldo, MP1
Bersani-Amado, CA; Cuman, RK; Gomes, ML; Marques-Araujo, S; Pupulin, AR; Takejima, E; Toledo, MJ1
Batista, Dda G; Batista, MM; Boykin, DW; Britto, CC; de Oliveira, GM; Rodrigues, AC; Soeiro, Mde N; Stephens, CE1
Combes, V; Grau, GE; Hempel, C; Hunt, NH; Kurtzhals, JA1
Aguiar, C; Almeida, EA; Batista, AM; Costa, SC; Guariento, ME; Pavan, TB; Wanderley, JS1
Bahia, MT; Gravel, AS; Lima, WG; Martins, TA; Santos, FM; Talvani, A; Torres, RM1
Cruz-Zetina, G; del Rio-Rodriguez, R; López, R; Monteon, V; Ramos-Ligonio, A1
Britto, C; Guhl, F; Lima-Ferreira, C; Marin-Neto, JA; Melo, MF; Moreira, OC; Morillo, CA; Ramírez, JD; Sosa-Estani, S; Velázquez, E1
Carlier, Y; Cencig, S; Coltel, N; Truyens, C1
Bahia, MT; Caldas, IS; de Andrade, IM; Diniz, Lde F; do Nascimento, ÁF; Martins, TA; Ribeiro, I; Talvani, A; Torreele, E; Trunz, BB1
Lopez, MO; Montanari, JA; Morilla, MJ; Petray, PB; Prieto, MJ; Romero, EL1
Altclas, J; De Rissio, AM; Dictar, M; García, MM; Luna, C; Riarte, A; Salgueira, C; Sinagra, A; Verón, MT1
Chiari, E; de Castro, AM; Galvão, LM; Luquetti, AO; Rassi, A1
Araújo-Jorge, T; Cotta-de-Almeida, V; de Castro, SL; de Souza, AP; Olivieri, BP1
Braz, LM; Gakiya, E; Ibrahim, KY; Lopes, MH; Nunes Westphalen, EV; Oliveira, OC; Sartori, AM; Shikanai-Yasuda, MA1
Bahia, MT; Caldas, S; de Lana, M; Diniz, LF; Machado-Coelho, GL; Santos, FM; Veloso, VM1
Bahia, MT; Caldas, IS; Caldas, S; Carneiro, CM; da Matta Guedes, PM; de Lana, M; Talvani, A1
Britto, C; Cardoso, MA; Hasslocher-Moreno, A; Morel, CM; Oelemann, W; Pirmez, C; Santoro, A; Vanni, CM; Wincker, P; Xavier, SS1
Murta, SM; Romanha, AJ1
Bayo, R; Ceraso, D; De Rissio, A; Dengra, C; Dictar, M; Koziner, B; Luna, C; Riarte, A; Segura, E; Sinagra, A; Verón, MT1
Alves, RO; Gazzinelli, RT; Murta, SM; Romanha, AJ; Ropert, C1
Bonté, F; Ferreira, ME; Fournet, A; Lavault, M; Nakayama, H; Rojas de Arias, A; Samudio, M; Schinini, A; Torres de Ortiz, S; Vera de Bilbao, N1
Bottasso, OA; Piaggio, E; Pitashny, M; Revelli, SS; Roggero, E; Wietzerbin, J1
Bahia, MT; Carneiro, CM; Chiari, E; Lana, M; Tafuri, WL; Toledo, MJ; Veloso, VM1
Andrade, SG; Andrade, ZA; Lima, ES1

Reviews

3 review(s) available for azomycin and Parasitemia

ArticleYear
Trypanocidal drugs for late-stage, symptomatic Chagas disease (Trypanosoma cruzi infection).
    The Cochrane database of systematic reviews, 2020, 12-11, Volume: 12

    Topics: Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Humans; Nifurtimox; Nitroimidazoles; Parasitemia; Placebos; Randomized Controlled Trials as Topic; Trypanocidal Agents; Trypanosoma cruzi

2020
Course of Chronic Trypanosoma cruzi Infection after Treatment Based on Parasitological and Serological Tests: A Systematic Review of Follow-Up Studies.
    PloS one, 2015, Volume: 10, Issue:10

    Topics: Adult; Antibodies, Protozoan; Chagas Disease; Child; Chronic Disease; Cohort Studies; Disease Progression; DNA, Protozoan; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique, Indirect; Follow-Up Studies; Hemagglutination Tests; Humans; Nifurtimox; Nitroimidazoles; Parasitemia; Randomized Controlled Trials as Topic; Treatment Failure; Trypanocidal Agents; Trypanosoma cruzi; Xenodiagnosis

2015
Chagas disease and transfusion medicine: a perspective from non-endemic countries.
    Blood transfusion = Trasfusione del sangue, 2015, Volume: 13, Issue:4

    Topics: Adult; Blood Donors; Blood Safety; Chagas Disease; Donor Selection; Emigration and Immigration; Enzyme-Linked Immunosorbent Assay; Europe; Female; Global Health; Health Services Needs and Demand; Humans; Infant, Newborn; Latin America; Male; Mass Screening; Nifurtimox; Nitroimidazoles; North America; Parasitemia; Pregnancy; Pregnancy Complications, Infectious; Transfusion Reaction; Travel; Trypanocidal Agents; Trypanosoma cruzi

2015

Trials

2 trial(s) available for azomycin and Parasitemia

ArticleYear
Distinct Treatment Outcomes of Antiparasitic Therapy in
    Frontiers in immunology, 2018, Volume: 9

    Topics: Adolescent; Chagas Disease; Chemokines; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Male; Nitroimidazoles; Parasitemia; T-Lymphocytes; Trypanosoma cruzi

2018
Antibody drop in newborns congenitally infected by Trypanosoma cruzi treated with benznidazole.
    Tropical medicine & international health : TM & IH, 2010, Volume: 15, Issue:1

    Topics: Antibodies, Protozoan; Chagas Disease; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Nitroimidazoles; Parasitemia; Pregnancy; Pregnancy Complications, Infectious; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi

2010

Other Studies

92 other study(ies) available for azomycin and Parasitemia

ArticleYear
4-nitrobenzoylcoumarin potentiates the antiparasitic, anti-inflammatory and cardioprotective effects of benznidazole in a murine model of acute Trypanosoma cruzi infection.
    Acta tropica, 2022, Volume: 228

    Topics: Animals; Anti-Inflammatory Agents; Antiparasitic Agents; Chagas Disease; Disease Models, Animal; Mice; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi

2022
Experimental Combination Therapy with Amiodarone and Low-Dose Benznidazole in a Mouse Model of Trypanosoma cruzi Acute Infection.
    Microbiology spectrum, 2022, 02-23, Volume: 10, Issue:1

    Topics: Amiodarone; Animals; Chagas Disease; Disease Models, Animal; Drug Therapy, Combination; Heart; Heart Diseases; Heart Function Tests; Humans; Male; Mice; Nitroimidazoles; Parasitemia; Trypanosoma cruzi

2022
Effectiveness of Nifurtimox in the Treatment of Chagas Disease: a Long-Term Retrospective Cohort Study in Children and Adults.
    Antimicrobial agents and chemotherapy, 2022, 05-17, Volume: 66, Issue:5

    Topics: Adult; Antibodies, Protozoan; Chagas Disease; Child; Cohort Studies; Humans; Nifurtimox; Nitroimidazoles; Parasitemia; Retrospective Studies; Trypanocidal Agents; Trypanosoma cruzi

2022
Miltefosine and Benznidazole Combination Improve Anti-
    Frontiers in cellular and infection microbiology, 2022, Volume: 12

    Topics: Animals; Chagas Disease; Mice; Nitroimidazoles; Parasitemia; Phosphorylcholine; Trypanocidal Agents; Trypanosoma cruzi

2022
Biological characteristics of the Trypanosoma cruzi Arequipa strain make it a good model for Chagas disease drug discovery.
    Acta tropica, 2022, Volume: 236

    Topics: Animals; Chagas Disease; Drug Discovery; Life Cycle Stages; Mice; Mice, Inbred BALB C; Nitroimidazoles; Parasitemia; Parasites; Trypanocidal Agents; Trypanosoma cruzi

2022
Long-term cardiology outcomes in children after early treatment for Chagas disease, an observational study.
    PLoS neglected tropical diseases, 2022, Volume: 16, Issue:12

    Topics: Adult; Cardiology; Chagas Cardiomyopathy; Chagas Disease; Child; Humans; Nifurtimox; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi

2022
Trypanosoma cruzi: Does the intake of nanoencapsulated benznidazole control acute infections?
    Experimental parasitology, 2023, Volume: 249

    Topics: Animals; Chagas Disease; Female; Mice; Nanocapsules; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi

2023
Sesquiterpene lactone potentiates the immunomodulatory, antiparasitic and cardioprotective effects on anti-Trypanosoma cruzi specific chemotherapy.
    International immunopharmacology, 2019, Volume: 77

    Topics: Animals; Antiparasitic Agents; Cardiotonic Agents; Cell Line; Chagas Disease; Cytokines; Female; Immunologic Factors; Inflammation; Lactones; Mice; Myocarditis; Nitroimidazoles; Parasitemia; Rats; Sesquiterpenes; Trypanosoma cruzi; Tumor Necrosis Factor-alpha

2019
Efficacy of the Benznidazole+Posaconazole combination therapy in parasitemia reduction: An experimental murine model of acute Chagas.
    Revista da Sociedade Brasileira de Medicina Tropical, 2020, Volume: 53

    Topics: Acute Disease; Animals; Chagas Disease; Disease Models, Animal; Disease Progression; DNA, Protozoan; Drug Therapy, Combination; Nitroimidazoles; Parasite Load; Parasitemia; Rats; Rats, Wistar; Triazoles; Trypanocidal Agents

2020
Antiparasitic and anti-inflammatory activities of ß-lapachone-derived naphthoimidazoles in experimental acute Trypanosoma cruzi infection.
    Memorias do Instituto Oswaldo Cruz, 2020, Volume: 115

    Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Chagas Disease; Disease Models, Animal; Electrocardiography; Male; Mice; Naphthoquinones; Nitroimidazoles; Parasitemia; Time Factors; Trypanocidal Agents

2020
Benznidazole/Poloxamer 407 Solid Dispersion as a New Strategy to Improve the Treatment of Experimental Trypanosoma cruzi Infection.
    The Journal of parasitology, 2020, 06-01, Volume: 106, Issue:3

    Topics: Acute Disease; Animals; Antibodies, Protozoan; Aspartate Aminotransferases; Chagas Disease; Chronic Disease; Disease Models, Animal; Excipients; Female; Heart; Mice; Myocardium; Nitroimidazoles; Parasitemia; Poloxamer; Quadriceps Muscle; Random Allocation; Real-Time Polymerase Chain Reaction; Trypanocidal Agents; Trypanosoma cruzi

2020
Amlodipine Increases the Therapeutic Potential of Ravuconazole upon Trypanosoma cruzi Infection.
    Antimicrobial agents and chemotherapy, 2020, 07-22, Volume: 64, Issue:8

    Topics: Amlodipine; Animals; Chagas Disease; Mice; Nitroimidazoles; Parasitemia; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi

2020
Thioridazine aggravates skeletal myositis, systemic and liver inflammation in Trypanosoma cruzi-infected and benznidazole-treated mice.
    International immunopharmacology, 2020, Volume: 85

    Topics: Acetylglucosaminidase; Animals; Chagas Disease; Cytokines; Disease Models, Animal; Drug Combinations; Female; Glycogen; Hepatitis; Mice; Muscle, Skeletal; Myositis; NADH, NADPH Oxidoreductases; Nitroimidazoles; Parasite Load; Parasitemia; Peroxidase; Thioridazine; Transaminases; Trypanocidal Agents; Trypanosoma cruzi

2020
Activity profile of two 5-nitroindazole derivatives over the moderately drug-resistant
    Parasitology, 2020, Volume: 147, Issue:11

    Topics: Animals; Cell Line; Chagas Disease; Drug Resistance; Drug Therapy, Combination; Humans; Indazoles; Mice; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi

2020
In vitro and in vivo activity of voriconazole and benznidazole combination on trypanosoma cruzi infection models.
    Acta tropica, 2020, Volume: 211

    Topics: Animals; Chagas Disease; Chlorocebus aethiops; Drug Synergism; In Vitro Techniques; Mice; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells; Voriconazole

2020
Evaluation of the anti-Trypanosoma cruzi activity in vitro and in vivo of silibinin and silibinin in association to benznidazole.
    Parasitology research, 2021, Volume: 120, Issue:4

    Topics: Animals; Chagas Disease; Chlorocebus aethiops; Female; Heart; Inhibitory Concentration 50; Mice; Nitroimidazoles; Parasitemia; Real-Time Polymerase Chain Reaction; Silybin; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells

2021
IgG Subclass Analysis in Patients with Chagas Disease 4 Years After Benznidazole Treatment.
    Acta parasitologica, 2021, Volume: 66, Issue:4

    Topics: Chagas Disease; Humans; Immunoglobulin G; Nitroimidazoles; Parasitemia

2021
Improved efficacy and safety of low doses of benznidazole-loaded multiparticulate delivery systems in experimental Chagas disease therapy.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2021, Sep-01, Volume: 164

    Topics: Animals; Chagas Disease; Mice; Mice, Inbred BALB C; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi

2021
Therapeutic effects of benznidazole in Swiss mice that are orally inoculated with Trypanosoma cruzi IV strains from the Western Brazilian Amazon.
    Experimental parasitology, 2021, Volume: 228

    Topics: Abdominal Wall; Animals; Brazil; Chagas Disease; Esophagus; Heart; Mice; Nitroimidazoles; Parasite Load; Parasitemia; Stomach; Trypanocidal Agents; Trypanosoma cruzi

2021
HIV and Chagas Disease: An Evaluation of the Use of Real-Time Quantitative Polymerase Chain Reaction to Measure Levels of Trypanosoma cruzi Parasitemia in HIV Patients in Cochabamba, Bolivia.
    The American journal of tropical medicine and hygiene, 2021, 08-16, Volume: 105, Issue:3

    Topics: Adult; Antibodies, Protozoan; Bolivia; CD4 Lymphocyte Count; Chagas Disease; Coinfection; Cross-Sectional Studies; Female; HIV Infections; Humans; Latent Infection; Male; Microscopy; Middle Aged; Nitroimidazoles; Parasite Load; Parasitemia; Real-Time Polymerase Chain Reaction; Trypanocidal Agents; Trypanosoma cruzi; Viral Load

2021
Development and in vitro/in vivo evaluation of a novel benznidazole liquid dosage form using a quality-by-design approach.
    Tropical medicine & international health : TM & IH, 2017, Volume: 22, Issue:12

    Topics: Alcohols; Animals; Chagas Disease; Chemistry, Pharmaceutical; Child; Chlorocebus aethiops; Contraindications; Dosage Forms; Humans; Mice, Inbred BALB C; Nitroimidazoles; Parasitemia; Polyethylene Glycols; Propylene Glycol; Solubility; Solvents; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells; Water

2017
Efficacy of essential oil of Syzygium aromaticum alone and in combination with benznidazole on murine oral infection with Trypanosoma cruzi IV.
    Experimental parasitology, 2018, Volume: 185

    Topics: Animals; Chagas Disease; Cyclophosphamide; Drug Therapy, Combination; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Insect Vectors; Male; Mice; Nitroimidazoles; Oils, Volatile; Parasitemia; Plant Oils; Rhodnius; Syzygium; Trypanocidal Agents; Trypanosoma cruzi

2018
A novel antibody surrogate biomarker to monitor parasite persistence in Trypanosoma cruzi-infected patients.
    PLoS neglected tropical diseases, 2018, Volume: 12, Issue:2

    Topics: Animals; Antibodies, Protozoan; Antigens, Protozoan; Biomarkers; Brazil; Chagas Disease; DNA, Protozoan; Humans; Immunoassay; Nitroimidazoles; Parasite Load; Parasitemia; Polymerase Chain Reaction; Sensitivity and Specificity; Serologic Tests; Trypanosoma cruzi

2018
Molecular and biological characterization of a highly pathogenic Trypanosoma cruzi strain isolated from a patient with congenital infection.
    Experimental parasitology, 2018, Volume: 186

    Topics: Animals; Brain; Chagas Disease; Chlorocebus aethiops; Disease Models, Animal; DNA, Protozoan; Female; Heart; Humans; Infant; Infectious Disease Transmission, Vertical; Inhibitory Concentration 50; Male; Mice; Mice, Inbred BALB C; Muscle, Skeletal; Myocardium; Nifurtimox; Nitroimidazoles; Parasitemia; Random Allocation; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells

2018
In vitro and in vivo drug combination for the treatment of Trypanosoma cruzi infection: A multivariate approach.
    Experimental parasitology, 2018, Volume: 189

    Topics: Animals; Chagas Disease; Clomipramine; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Female; Inhibitory Concentration 50; Male; Mice; Multivariate Analysis; Muscle, Skeletal; Myocardium; Nitroimidazoles; Parasitemia; Principal Component Analysis; Real-Time Polymerase Chain Reaction; Trypanocidal Agents; Trypanosoma cruzi

2018
Anti-parasitic effect of vitamin C alone and in combination with benznidazole against Trypanosoma cruzi.
    PLoS neglected tropical diseases, 2018, Volume: 12, Issue:9

    Topics: Animals; Ascorbic Acid; Body Weight; Chagas Disease; Chlorocebus aethiops; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Female; Mice, Inbred C3H; Nitroimidazoles; Parasite Load; Parasitemia; Survival Analysis; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells

2018
Parasitaemia and parasitic load are limited targets of the aetiological treatment to control the progression of cardiac fibrosis and chronic cardiomyopathy in Trypanosoma cruzi-infected dogs.
    Acta tropica, 2019, Volume: 189

    Topics: Acute Disease; Animals; Chagas Cardiomyopathy; Chronic Disease; Collagen Type III; Disease Models, Animal; Disease Progression; DNA, Protozoan; Dogs; Drug Resistance; Fibrosis; Heart; Myocardium; Nitroimidazoles; Parasite Load; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi

2019
The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi.
    Memorias do Instituto Oswaldo Cruz, 2018, Oct-18, Volume: 113, Issue:11

    Topics: Acute Disease; Adrenergic beta-Antagonists; Animals; Carvedilol; Catalase; Chagas Disease; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Heart; Male; Mice, Inbred C57BL; Myocardium; Nitroimidazoles; Oxidative Stress; Parasitemia; Protein Carbonylation; Reference Values; Reproducibility of Results; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Time Factors; Trypanocidal Agents; Trypanosoma cruzi

2018
Beneficial effects of benznidazole in Chagas disease: NIH SaMi-Trop cohort study.
    PLoS neglected tropical diseases, 2018, Volume: 12, Issue:11

    Topics: Aftercare; Brazil; Chagas Disease; Chronic Disease; Follow-Up Studies; Humans; National Institutes of Health (U.S.); Nitroimidazoles; Parasitemia; Prospective Studies; Trypanocidal Agents; Trypanosoma cruzi; United States

2018
Indirubin derivatives are potent and selective anti-Trypanosoma cruzi agents.
    Virulence, 2018, Volume: 9, Issue:1

    Topics: Animals; Chagas Disease; Disease Models, Animal; Female; Flow Cytometry; Indoles; Mice; Mice, Inbred BALB C; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi

2018
Impact of levamisole in co-administration with benznidazole on experimental Chagas disease.
    Parasitology, 2019, Volume: 146, Issue:8

    Topics: Animals; Chagas Disease; Drug Therapy, Combination; Female; Levamisole; Male; Mice; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi

2019
Concomitant exercise training attenuates the cardioprotective effects of pharmacological therapy in a murine model of acute infectious myocarditis.
    Life sciences, 2019, Aug-01, Volume: 230

    Topics: Animals; Antioxidants; Cardiotonic Agents; Catalase; Chagas Cardiomyopathy; Chagas Disease; Cytokines; Disease Models, Animal; Heart; Inflammation; Interleukin-10; Male; Myocarditis; Myocardium; Nitric Oxide; Nitroimidazoles; Parasitemia; Physical Conditioning, Animal; Rats; Rats, Wistar; Superoxide Dismutase; Trypanosoma cruzi; Tumor Necrosis Factor-alpha

2019
Benznidazole, itraconazole and their combination in the treatment of acute experimental chagas disease in dogs.
    Experimental parasitology, 2019, Volume: 204

    Topics: Acute Disease; Animals; Chagas Disease; DNA, Protozoan; Dogs; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Female; Heart; Humans; Itraconazole; Male; Myocardium; Nitroimidazoles; Parasitemia; Polymerase Chain Reaction; Random Allocation; Trypanocidal Agents

2019
Could pre-infection exercise training improve the efficacy of specific antiparasitic chemotherapy for Chagas disease?
    Parasitology, 2019, Volume: 146, Issue:13

    Topics: Animals; Antiparasitic Agents; Cardiotonic Agents; Chagas Disease; Cytokines; Disease Models, Animal; Drug Administration Schedule; Heart; Male; Myocarditis; Nitroimidazoles; Parasitemia; Physical Conditioning, Animal; Rats; Rats, Wistar; Running; Trypanosoma cruzi

2019
Clomipramine and benznidazole association for the treatment of acute experimental Trypanosoma cruzi infection.
    Parasitology international, 2013, Volume: 62, Issue:3

    Topics: Animals; Chagas Disease; Clomipramine; Disease Models, Animal; Drug Evaluation, Preclinical; Electrocardiography; Female; Intestines; Kidney; Liver; Male; Mice; Muscle, Skeletal; Myocardium; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi

2013
In vivo activity of ursolic and oleanolic acids during the acute phase of Trypanosoma cruzi infection.
    Experimental parasitology, 2013, Volume: 134, Issue:4

    Topics: Acute Disease; Administration, Oral; Animals; Anti-Infective Agents; Chagas Disease; Disease Models, Animal; Infusions, Parenteral; Interferon-gamma; Interleukin-10; Male; Melastomataceae; Mice; Mice, Inbred BALB C; Nitroimidazoles; Oleanolic Acid; Parasitemia; Random Allocation; Triterpenes; Trypanocidal Agents; Ursolic Acid

2013
New, combined, and reduced dosing treatment protocols cure Trypanosoma cruzi infection in mice.
    The Journal of infectious diseases, 2014, Jan-01, Volume: 209, Issue:1

    Topics: Animals; Biomarkers; CD8-Positive T-Lymphocytes; Chagas Disease; DNA; Drug Resistance; Drug Therapy, Combination; Immunophenotyping; Mice; Mice, Inbred C57BL; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi

2014
Benznidazole and posaconazole in experimental Chagas disease: positive interaction in concomitant and sequential treatments.
    PLoS neglected tropical diseases, 2013, Volume: 7, Issue:8

    Topics: Animals; Antiprotozoal Agents; Chagas Disease; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Female; Mice; Nitroimidazoles; Parasitemia; Treatment Outcome; Triazoles; Trypanosoma cruzi

2013
Evaluation of trypanocidal drugs used for human African trypanosomosis against Trypanosoma lewisi.
    Parasite (Paris, France), 2013, Volume: 20

    Topics: Animals; Eflornithine; Female; Humans; Immunocompromised Host; Inhibitory Concentration 50; Melarsoprol; Mice; Nifurtimox; Nitroimidazoles; Parasitemia; Pentamidine; Rats; Rats, Wistar; Suramin; Trypanocidal Agents; Trypanosoma lewisi; Trypanosomiasis

2013
Reversible cysteine protease inhibitors show promise for a Chagas disease cure.
    Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:2

    Topics: Administration, Oral; Animals; Area Under Curve; Chagas Disease; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Inhibitory Concentration 50; Life Cycle Stages; Male; Mice; Nitroimidazoles; Parasitemia; Protozoan Proteins; Survival Analysis; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi

2014
In vitro and in vivo biological effects of novel arylimidamide derivatives against Trypanosoma cruzi.
    Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:7

    Topics: Amidines; Animals; Cell Survival; Chagas Disease; Galactosidases; Male; Mice; Nitroimidazoles; No-Observed-Adverse-Effect Level; Parasitemia; Primary Cell Culture; Trypanocidal Agents; Trypanosoma cruzi

2014
Development of novel benznidazole formulations: physicochemical characterization and in vivo evaluation on parasitemia reduction in Chagas disease.
    International journal of pharmaceutics, 2014, Sep-10, Volume: 472, Issue:1-2

    Topics: Animals; Calorimetry, Differential Scanning; Cellulose; Chagas Disease; Chemistry, Pharmaceutical; Crystallization; Deoxycholic Acid; Drug Carriers; Female; Mice; Microscopy, Electron, Scanning; Nitroimidazoles; Parasitemia; Powder Diffraction; Trypanocidal Agents; X-Ray Diffraction

2014
Ruthenium complex with benznidazole and nitric oxide as a new candidate for the treatment of chagas disease.
    PLoS neglected tropical diseases, 2014, Volume: 8, Issue:10

    Topics: Animals; Chagas Disease; Drug Resistance; Drug Therapy, Combination; Female; Heart; Humans; Inflammation; Mice; Nitric Oxide; Nitroimidazoles; Parasitemia; Ruthenium; Trypanocidal Agents; Trypanosoma cruzi

2014
Experimental benznidazole treatment of Trypanosoma cruzi II strains isolated from children of the Jequitinhonha Valley, Minas Gerais, Brazil, with Chagas disease.
    Memorias do Instituto Oswaldo Cruz, 2015, Volume: 110, Issue:1

    Topics: Animals; Antibodies, Protozoan; Area Under Curve; Brazil; Chagas Disease; Child; Disease Models, Animal; Drug Resistance; Enzyme-Linked Immunosorbent Assay; Female; Fibrosis; Flow Cytometry; Humans; Inflammation; Mice; Myocardium; Nitroimidazoles; Parasitemia; Polymerase Chain Reaction; Primary Cell Culture; Remission Induction; Statistics, Nonparametric; Trypanocidal Agents; Trypanosoma cruzi

2015
Impact of benznidazole on infection course in mice experimentally infected with Trypanosoma cruzi I, II, and IV.
    The American journal of tropical medicine and hygiene, 2015, Volume: 92, Issue:6

    Topics: Animals; Chagas Disease; DNA, Protozoan; Male; Mice; Nitroimidazoles; Parasitemia; Real-Time Polymerase Chain Reaction; Trypanocidal Agents; Trypanosoma cruzi

2015
In vivo and in vitro auranofin activity against Trypanosoma cruzi: Possible new uses for an old drug.
    Experimental parasitology, 2016, Volume: 166

    Topics: Animals; Antirheumatic Agents; Auranofin; Cell Line; Chagas Disease; Female; Fibroblasts; Humans; Inhibitory Concentration 50; Lethal Dose 50; Mice; Mice, Inbred BALB C; Nitroimidazoles; Parasitemia; Random Allocation; Specific Pathogen-Free Organisms; Trypanocidal Agents; Trypanosoma cruzi

2016
An in vitro iron superoxide dismutase inhibitor decreases the parasitemia levels of Trypanosoma cruzi in BALB/c mouse model during acute phase.
    International journal for parasitology. Drugs and drug resistance, 2015, Volume: 5, Issue:3

    Topics: Animals; Chagas Disease; Cyclophosphamide; Immunocompromised Host; Immunosuppressive Agents; Mice; Mice, Inbred BALB C; Molecular Structure; Nitroimidazoles; Parasitemia; Superoxide Dismutase; Trypanocidal Agents; Trypanosoma cruzi

2015
Antitrypanosomal Treatment with Benznidazole Is Superior to Posaconazole Regimens in Mouse Models of Chagas Disease.
    Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:10

    Topics: 14-alpha Demethylase Inhibitors; Administration, Oral; Animals; Chagas Disease; Clinical Trials, Phase II as Topic; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Heart; Humans; Immunosuppression Therapy; Mice; NIH 3T3 Cells; Nitroimidazoles; Parasitemia; Recurrence; Sterol 14-Demethylase; Triazoles; Trypanocidal Agents; Trypanosoma cruzi

2015
The in vivo trypanocidal effect of the diterpene 5-epi-icetexone obtained from Salvia gilliesii.
    Parasitology international, 2016, Volume: 65, Issue:1

    Topics: Administration, Oral; Animals; Chagas Disease; Dimethyl Sulfoxide; Disease Models, Animal; Diterpenes; Heart; Mice; Muscle, Skeletal; Myocardium; Nitroimidazoles; Parasitemia; Salvia; Trypanocidal Agents; Trypanosoma cruzi

2016
Different Therapeutic Outcomes of Benznidazole and VNI Treatments in Different Genders in Mouse Experimental Models of Trypanosoma cruzi Infection.
    Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:12

    Topics: 14-alpha Demethylase Inhibitors; Animals; Chagas Disease; Cytochrome P-450 Enzyme System; Disease Models, Animal; Drug Administration Schedule; Drug Evaluation, Preclinical; Female; Gene Expression; Imidazoles; Immunosuppressive Agents; Male; Mice; Nitroimidazoles; Oxadiazoles; Parasitemia; Sex Factors; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi

2015
Structural design, synthesis and pharmacological evaluation of 4-thiazolidinones against Trypanosoma cruzi.
    Bioorganic & medicinal chemistry, 2015, Dec-01, Volume: 23, Issue:23

    Topics: Animals; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Hydrazones; Mice; Mice, Inbred BALB C; Nitroimidazoles; Parasitemia; Protozoan Proteins; Structure-Activity Relationship; Thiazolidines; Thiosemicarbazones; Trypanocidal Agents; Trypanosoma cruzi

2015
In Vitro and In Vivo Trypanosomicidal Action of Novel Arylimidamides against Trypanosoma cruzi.
    Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:4

    Topics: Amides; Amidines; Animals; Chagas Disease; Disease Models, Animal; Drug Administration Schedule; Drug Dosage Calculations; Drug Synergism; Drug Therapy, Combination; Female; Mice; Nitroimidazoles; Parasite Load; Parasitemia; Parasitic Sensitivity Tests; Structure-Activity Relationship; Survival Analysis; Terphenyl Compounds; Trypanocidal Agents; Trypanosoma cruzi

2016
Low-dose benznidazole treatment results in parasite clearance and attenuates heart inflammatory reaction in an experimental model of infection with a highly virulent Trypanosoma cruzi strain.
    International journal for parasitology. Drugs and drug resistance, 2016, Volume: 6, Issue:1

    Topics: Animals; Cells, Cultured; Chagas Cardiomyopathy; Chagas Disease; Creatine Kinase; Disease Models, Animal; Dose-Response Relationship, Drug; Heart; Humans; Immunologic Factors; Inflammation; Interleukin-6; Mice; Mice, Inbred BALB C; Myocytes, Cardiac; NF-kappa B; Nitric Oxide Synthase Type II; Nitroimidazoles; Parasite Load; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi; Tumor Necrosis Factor-alpha

2016
Curcumin Enhances the Anti-Trypanosoma cruzi Activity of Benznidazole-Based Chemotherapy in Acute Experimental Chagas Disease.
    Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:6

    Topics: Acute Disease; Animals; Chagas Disease; Curcumin; Cytokines; Female; Liver; Mice; Myocardium; Nitroimidazoles; Parasitemia; Transaminases; Trypanocidal Agents; Trypanosoma cruzi

2016
Clomipramine and Benznidazole Act Synergistically and Ameliorate the Outcome of Experimental Chagas Disease.
    Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:6

    Topics: Animals; Chagas Disease; Clomipramine; Disease Models, Animal; Drug Administration Schedule; Drug Combinations; Drug Synergism; Heart; Male; Mice; Mice, Inbred BALB C; Nitroimidazoles; Parasitemia; Parasitic Sensitivity Tests; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi

2016
Promising Efficacy of Benznidazole Nanoparticles in Acute Trypanosoma cruzi Murine Model: In-Vitro and In-Vivo Studies.
    The American journal of tropical medicine and hygiene, 2016, 08-03, Volume: 95, Issue:2

    Topics: Animals; Chagas Disease; Chlorocebus aethiops; Dose-Response Relationship, Drug; Drug Carriers; Female; Life Cycle Stages; Mice; Mice, Inbred C3H; Myocytes, Cardiac; Nanoparticles; Nitroimidazoles; Parasitemia; Particle Size; Poloxamer; Primary Cell Culture; Survival Analysis; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells

2016
Pentamidine antagonizes the benznidazole's effect in vitro, and lacks of synergy in vivo: Implications about the polyamine transport as an anti-Trypanosoma cruzi target.
    Experimental parasitology, 2016, Volume: 171

    Topics: Animals; Chagas Disease; Chlorocebus aethiops; DNA, Protozoan; Dose-Response Relationship, Drug; Glutathione; Macrophages; Male; Mice; Mice, Inbred BALB C; Myocardium; Nitroimidazoles; Parasitemia; Pentamidine; Putrescine; Random Allocation; Spermidine; Thymidine; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells

2016
Simvastatin Attenuates Endothelial Activation through 15-Epi-Lipoxin A4 Production in Murine Chronic Chagas Cardiomyopathy.
    Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:3

    Topics: Animals; Anticholesteremic Agents; Arachidonate 5-Lipoxygenase; Chagas Cardiomyopathy; Chronic Disease; Disease Models, Animal; Drug Therapy, Combination; E-Selectin; Endothelium; Gene Expression Regulation; Humans; Intercellular Adhesion Molecule-1; Lipoxins; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Myocardium; Nitroimidazoles; Parasitemia; Simvastatin; Survival Analysis; Trypanocidal Agents; Trypanosoma cruzi; Vascular Cell Adhesion Molecule-1

2017
Treatment of Infected Women of Childbearing Age Prevents Congenital Trypanosoma cruzi Infection by Eliminating the Parasitemia Detected by PCR.
    The Journal of infectious diseases, 2017, 05-01, Volume: 215, Issue:9

    Topics: Adult; Antibiotic Prophylaxis; Chagas Disease; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Nitroimidazoles; Parasitemia; Polymerase Chain Reaction; Pregnancy; Pregnancy Complications, Parasitic; Prospective Studies; Trypanocidal Agents

2017
Nitrotriazole-Based Compounds as Antichagasic Agents in a Long-Treatment
    Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:5

    Topics: Animals; Chagas Disease; Dose-Response Relationship, Drug; Female; Mice; Nitroimidazoles; Parasitemia; Triazoles; Trypanocidal Agents; Trypanosoma cruzi

2017
Trypanosoma cruzi: effect of benznidazole therapy combined with the iron chelator desferrioxamine in infected mice.
    Experimental parasitology, 2008, Volume: 120, Issue:4

    Topics: Analysis of Variance; Animals; Chagas Disease; Deferoxamine; Disease Models, Animal; Drug Therapy, Combination; Hemoglobins; Iron; Liver; Male; Mice; Nitroimidazoles; Parasitemia; Polymerase Chain Reaction; Random Allocation; Siderophores; Trypanocidal Agents; Trypanosoma cruzi

2008
Trypanosoma cruzi: Induction of benznidazole resistance in vivo and its modulation by in vitro culturing and mice infection.
    Experimental parasitology, 2008, Volume: 120, Issue:4

    Topics: Animals; Chagas Disease; Cyclophosphamide; Dogs; Drug Resistance; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Mice; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi

2008
Efficacy of benznidazol treatment for asymptomatic chagasic patients from state of Rio Grande do Sul evaluated during a three years follow-up.
    Memorias do Instituto Oswaldo Cruz, 2009, Volume: 104, Issue:1

    Topics: Adult; Animals; Case-Control Studies; Chagas Disease; Chronic Disease; Cohort Studies; DNA, Kinetoplast; Enzyme-Linked Immunosorbent Assay; Female; Fluorescent Antibody Technique, Indirect; Follow-Up Studies; Humans; Male; Nitroimidazoles; Parasitemia; Polymerase Chain Reaction; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi; Young Adult

2009
Reduction of parasite levels in blood improves pregnancy outcome during experimental Trypanosoma cruzi infection.
    Parasitology, 2009, Volume: 136, Issue:6

    Topics: Animals; Antibodies, Protozoan; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; CD4-Positive T-Lymphocytes; Chagas Disease; Female; Gene Expression Regulation; Hyaluronan Receptors; Immunoglobulin G; Interferon-gamma; Lectins, C-Type; Mice; Nitroimidazoles; Parasitemia; Placenta; Pregnancy; Pregnancy Complications, Parasitic; Pregnancy Outcome; Spleen; Time Factors; Trypanosoma cruzi

2009
Trypanosoma cruzi: Immunological predictors of benznidazole efficacy during experimental infection.
    Experimental parasitology, 2010, Volume: 124, Issue:2

    Topics: Animals; Antibodies, Protozoan; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; CD4 Lymphocyte Count; CD8-Positive T-Lymphocytes; Chagas Disease; DNA, Protozoan; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Fluorescent Antibody Technique; Hyaluronan Receptors; Immunoglobulin G; Immunophenotyping; Lectins, C-Type; Male; Mice; Mice, Inbred C3H; Muscle, Skeletal; Nitroimidazoles; Parasitemia; Polymerase Chain Reaction; Spleen; T-Lymphocytes; Trypanocidal Agents; Trypanosoma cruzi

2010
Benznidazole alters the pattern of Cyclophosphamide-induced reactivation in experimental Trypanosoma cruzi-dependent lineage infection.
    Acta tropica, 2010, Volume: 113, Issue:2

    Topics: Animals; Chagas Disease; Cyclophosphamide; Female; Genetic Variation; Immunosuppression Therapy; Immunosuppressive Agents; Mice; Nitroimidazoles; Parasitemia; Secondary Prevention; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi

2010
Nitric oxide donor trans-[RuCl([15]aneN)NO] as a possible therapeutic approach for Chagas' disease.
    British journal of pharmacology, 2010, Volume: 160, Issue:2

    Topics: Animals; Chagas Cardiomyopathy; Chagas Disease; Disease Models, Animal; Drug Resistance; Drug Synergism; Female; Humans; Macrophages; Mice; Nitric Oxide; Nitric Oxide Donors; Nitroimidazoles; Organometallic Compounds; Parasitemia; Survival Rate; Trypanocidal Agents; Trypanosoma cruzi

2010
Effects of dehydroepiandrosterone-sulfate (DHEA-S) and benznidazole treatments during acute infection of two different Trypanosoma cruzi strains.
    Immunobiology, 2010, Volume: 215, Issue:12

    Topics: Acute Disease; Animals; Chagas Disease; Dehydroepiandrosterone Sulfate; Drug Therapy, Combination; Interferon-gamma; Interleukin-2; Macrophages, Peritoneal; Male; Nitrites; Nitroimidazoles; Parasitemia; Rats; Rats, Wistar; Species Specificity; Survival Rate; Time Factors; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi

2010
Canova medication modifies parasitological parameters in mice infected with Trypanosoma cruzi.
    Experimental parasitology, 2010, Volume: 126, Issue:4

    Topics: Animals; Chagas Disease; Crotalid Venoms; Drug Therapy, Combination; Formularies, Homeopathic as Topic; Heart; Host-Pathogen Interactions; Intestines; Liver; Male; Mice; Nitroimidazoles; Parasitemia; Plant Extracts; Spleen; Trypanocidal Agents; Trypanosoma cruzi

2010
Combined treatment of heterocyclic analogues and benznidazole upon Trypanosoma cruzi in vivo.
    PloS one, 2011, Volume: 6, Issue:7

    Topics: Amidines; Animals; Antifungal Agents; Benzamidines; Chagas Disease; Drug Combinations; Furans; Male; Mice; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi

2011
CNS hypoxia is more pronounced in murine cerebral than noncerebral malaria and is reversed by erythropoietin.
    The American journal of pathology, 2011, Volume: 179, Issue:4

    Topics: Animals; Brain; Disease Models, Animal; Erythropoietin; Female; Fluorescent Dyes; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Malaria, Cerebral; Mice; Nitroimidazoles; Parasitemia; Plasmodium berghei; Poly(ADP-ribose) Polymerases; Survival Analysis; Treatment Outcome

2011
Serological profiles and evaluation of parasitaemia by PCR and blood culture in individuals chronically infected by Trypanosoma cruzi treated with benzonidazole.
    Tropical medicine & international health : TM & IH, 2012, Volume: 17, Issue:3

    Topics: Adult; Age Factors; Antibodies, Protozoan; Chagas Disease; Chronic Disease; DNA, Protozoan; Enzyme-Linked Immunosorbent Assay; Female; Fluorescent Antibody Technique, Indirect; Humans; Male; Nitroimidazoles; Parasitemia; Polymerase Chain Reaction; Retrospective Studies; Treatment Failure; Trypanocidal Agents; Trypanosoma cruzi; Young Adult

2012
Cardiomyopathy prognosis after benznidazole treatment in chronic canine Chagas' disease.
    The Journal of antimicrobial chemotherapy, 2012, Volume: 67, Issue:8

    Topics: Animal Experimentation; Animals; Antiprotozoal Agents; Chagas Cardiomyopathy; Chronic Disease; DNA, Protozoan; Dog Diseases; Dogs; Heart; Nitroimidazoles; Parasitemia; Prognosis; Trypanosoma cruzi

2012
Decreased intensity of inflammation in benznidazole-treated mice inoculated with Trypanosoma cruzi I stocks from Mexico and persistence of circulating parasites.
    The American journal of tropical medicine and hygiene, 2012, Volume: 87, Issue:4

    Topics: Animals; Cardiomyopathies; Chagas Disease; Genotype; Heart; Inflammation; Mexico; Mice; Mice, Inbred BALB C; Muscle, Skeletal; Nitroimidazoles; Parasitemia; Polymerase Chain Reaction; Trypanocidal Agents; Trypanosoma cruzi

2012
Towards the establishment of a consensus real-time qPCR to monitor Trypanosoma cruzi parasitemia in patients with chronic Chagas disease cardiomyopathy: a substudy from the BENEFIT trial.
    Acta tropica, 2013, Volume: 125, Issue:1

    Topics: Antiprotozoal Agents; Argentina; Brazil; Chagas Cardiomyopathy; Colombia; DNA, Protozoan; Double-Blind Method; Drug Monitoring; Humans; Molecular Diagnostic Techniques; Nitroimidazoles; Parasite Load; Parasitemia; Parasitology; Placebos; Randomized Controlled Trials as Topic; Real-Time Polymerase Chain Reaction; Reproducibility of Results; Sensitivity and Specificity; Specimen Handling; Trypanosoma cruzi

2013
Evaluation of benznidazole treatment combined with nifurtimox, posaconazole or AmBisome® in mice infected with Trypanosoma cruzi strains.
    International journal of antimicrobial agents, 2012, Volume: 40, Issue:6

    Topics: Amphotericin B; Animals; Chagas Disease; Disease Models, Animal; DNA, Protozoan; Drug Therapy, Combination; Female; Mice; Mice, Inbred BALB C; Nifurtimox; Nitroimidazoles; Parasite Load; Parasitemia; Real-Time Polymerase Chain Reaction; Treatment Outcome; Triazoles; Trypanocidal Agents; Trypanosoma cruzi

2012
Fexinidazole: a potential new drug candidate for Chagas disease.
    PLoS neglected tropical diseases, 2012, Volume: 6, Issue:11

    Topics: Administration, Oral; Animals; Antiprotozoal Agents; Chagas Disease; Disease Models, Animal; Female; Mice; Nitroimidazoles; Parasitemia; Survival Analysis; Treatment Outcome; Trypanosoma cruzi

2012
Intravenous liposomal benznidazole as trypanocidal agent: increasing drug delivery to liver is not enough.
    International journal of pharmaceutics, 2004, Jul-08, Volume: 278, Issue:2

    Topics: Animals; Chagas Disease; Female; Injections, Intravenous; Liposomes; Liver; Mice; Mice, Inbred BALB C; Nitroimidazoles; Parasitemia; Particle Size; Phospholipids; Rats; Rats, Wistar; Tissue Distribution; Trypanocidal Agents; Trypanosoma cruzi

2004
Chagas disease in bone marrow transplantation: an approach to preemptive therapy.
    Bone marrow transplantation, 2005, Volume: 36, Issue:2

    Topics: Adolescent; Adult; Aged; Bone Marrow Transplantation; Chagas Disease; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Middle Aged; Nitroimidazoles; Parasitemia; Retrospective Studies; Trypanocidal Agents

2005
Detection of parasitemia profiles by blood culture after treatment of human chronic Trypanosoma cruzi infection.
    Parasitology research, 2006, Volume: 99, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Animals; Antiparasitic Agents; Cell Culture Techniques; Female; Humans; Male; Middle Aged; Nitroimidazoles; Parasitemia; Trypanosoma cruzi; Trypanosomiasis

2006
Trypanosoma cruzi: alteration in the lymphoid compartments following interruption of infection by early acute benznidazole therapy in mice.
    Experimental parasitology, 2006, Volume: 114, Issue:3

    Topics: Acute Disease; Animals; B-Lymphocytes; Chagas Disease; Immunity, Cellular; Lymph Nodes; Lymphoid Tissue; Male; Mice; Nitroimidazoles; Parasitemia; Spleen; T-Lymphocytes; Thymus Gland; Trypanocidal Agents; Trypanosoma cruzi

2006
Manifestations of Chagas disease (American trypanosomiasis) in patients with HIV/AIDS.
    Annals of tropical medicine and parasitology, 2007, Volume: 101, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Adult; Brazil; Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Female; HIV Infections; Humans; Male; Meningoencephalitis; Middle Aged; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Xenodiagnosis

2007
Trypanosoma cruzi: acute and long-term infection in the vertebrate host can modify the response to benznidazole.
    Experimental parasitology, 2008, Volume: 118, Issue:3

    Topics: Animals; Chagas Disease; Cyclophosphamide; Dogs; Drug Resistance; Female; Humans; Immunosuppressive Agents; Mice; Nitroimidazoles; Parasitemia; Serial Passage; Trypanocidal Agents; Trypanosoma cruzi

2008
Benznidazole therapy during acute phase of Chagas disease reduces parasite load but does not prevent chronic cardiac lesions.
    Parasitology research, 2008, Volume: 103, Issue:2

    Topics: Acute Disease; Animals; Chagas Disease; Chronic Disease; Drug Resistance; Heart; Humans; Mice; Myocardium; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi

2008
Polymerase chain reaction detection of Trypanosoma cruzi in human blood samples as a tool for diagnosis and treatment evaluation.
    Parasitology, 1995, Volume: 110 ( Pt 3)

    Topics: Animals; Antibodies, Protozoan; Base Sequence; Chagas Disease; DNA, Kinetoplast; Humans; Molecular Sequence Data; Nitroimidazoles; Parasitemia; Polymerase Chain Reaction; Sensitivity and Specificity; Trypanosoma cruzi

1995
In vivo selection of a population of Trypanosoma cruzi and clones resistant to benznidazole.
    Parasitology, 1998, Volume: 116 ( Pt 2)

    Topics: Animals; Chagas Disease; Drug Resistance; Male; Mice; Nitroimidazoles; Parasitemia; Parasitology; Phenotype; Trypanocidal Agents; Trypanosoma cruzi

1998
Recipients and donors of bone marrow transplants suffering from Chagas' disease: management and preemptive therapy of parasitemia.
    Bone marrow transplantation, 1998, Volume: 21, Issue:4

    Topics: Adult; Bone Marrow Transplantation; Chagas Disease; Chronic Disease; Female; Humans; Immunosuppression Therapy; Leukemia; Lymphoma, Non-Hodgkin; Male; Middle Aged; Nitroimidazoles; Parasitemia; Recurrence; Transplantation, Autologous; Transplantation, Homologous; Trypanocidal Agents

1998
In-vivo treatment with benznidazole enhances phagocytosis, parasite destruction and cytokine release by macrophages during infection with a drug-susceptible but not with a derived drug-resistant Trypansoma cruzi population.
    Parasite immunology, 1999, Volume: 21, Issue:10

    Topics: Animals; Chagas Disease; Cytokines; Drug Resistance; Interleukin-12; Macrophages; Male; Mice; Nitric Oxide; Nitroimidazoles; Parasitemia; Phagocytosis; Trypanocidal Agents; Tumor Necrosis Factor-alpha

1999
Efficacy of the bisbenzylisoquinoline alkaloids in acute and chronic Trypanosoma cruzi murine model.
    International journal of antimicrobial agents, 2000, Volume: 13, Issue:3

    Topics: Acute Disease; Administration, Oral; Alkaloids; Animals; Benzylisoquinolines; Chagas Disease; Chronic Disease; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Immunoblotting; Isoquinolines; Male; Mice; Mice, Inbred BALB C; Nitroimidazoles; Parasitemia; Trypanocidal Agents

2000
Treatment with benznidazole and its immunomodulating effects on Trypanosoma cruzi-infected rats.
    Parasitology research, 2001, Volume: 87, Issue:7

    Topics: Adjuvants, Immunologic; Administration, Oral; Animals; Cells, Cultured; Chagas Disease; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Drug Therapy, Combination; Heart; Interferon-gamma; Macrophages, Peritoneal; Male; Myocarditis; Myocardium; Nitric Oxide; Nitroimidazoles; Parasitemia; Rats; Rats, Inbred Strains; Recombinant Proteins; Trypanocidal Agents; Trypanosoma cruzi

2001
Variation in susceptibility to benznidazole in isolates derived from Trypanosoma cruzi parental strains.
    Memorias do Instituto Oswaldo Cruz, 2001, Volume: 96, Issue:7

    Topics: Animals; Chagas Disease; Dogs; Drug Resistance; Enzyme-Linked Immunosorbent Assay; Mice; Nitroimidazoles; Parasitemia; Parasitology; Polymerase Chain Reaction; Trypanocidal Agents; Trypanosoma cruzi

2001
TNF-alpha is expressed at sites of parasite and tissue destruction in the spleen of mice acutely infected with Trypanosoma cruzi.
    International journal of experimental pathology, 2001, Volume: 82, Issue:6

    Topics: Acute Disease; Animals; Chagas Disease; Disease Susceptibility; Immunoenzyme Techniques; Macrophages; Mice; Mice, Inbred C3H; Mice, Inbred DBA; Necrosis; Nitroimidazoles; Parasitemia; Spleen; Survival Rate; Trypanocidal Agents; Tumor Necrosis Factor-alpha

2001