Page last updated: 2024-08-21

azomycin and Neoplasms

azomycin has been researched along with Neoplasms in 240 studies

Research

Studies (240)

TimeframeStudies, this research(%)All Research%
pre-199099 (41.25)18.7374
1990's33 (13.75)18.2507
2000's43 (17.92)29.6817
2010's57 (23.75)24.3611
2020's8 (3.33)2.80

Authors

AuthorsStudies
Abuteen, A; Dietz, C; Mohammad, I; Smith, MB; Zanganeh, S; Zhou, F; Zhu, Q1
Beiki, D; Binns, D; Cullinane, C; Ehrlichmann, W; Hicks, R; Kumar, P; Machulla, HJ; Naimi, E; Reischl, G; Roselt, P; Wiebe, LI; Yang, J1
Krohn, KA; Rajendran, JG1
Angermeier, A; Della Manna, D; Larimer, BM; Li, Y; Reeves, KM; Song, PN; Sorace, AG; Wang, J; Yang, ES1
Deep, G; Kim, S; Kumar, D; Rios-Colon, L; Su, Y1
Labiano, S; Rodriguez-Ruiz, ME; Serrano-Mendioroz, I1
Li, Y; Liu, M; Wang, Z; Zhao, Y; Zheng, Y1
Hay, MP; Hicks, KO; Hong, CR; Jamieson, SMF; Liew, LP; Shome, A; Wong, WW1
Ackerley, DF; Anderson, RF; Ashoorzadeh, A; Copp, JN; Flanagan, JU; Guise, CP; Mowday, AM; Patterson, AV; Rich, MH; Smaill, JB; Williams, EM1
Cheng, W; Hu, Y; Tian, X; Wang, S; Yang, Z1
Chen, H; Duan, K; Guo, J; Li, R; Wan, H; Xu, Y; Yuan, Z; Zhang, J; Zheng, J1
Bernauer, C; Chisholm, JC; Lepicard, EY; Man, YKS; Robinson, SP; Shipley, JM1
Bai, R; Chen, C; Du, P; Gao, F; Li, J; Liu, J; Liu, S; Liu, T; Lu, X; Ma, M; Qin, F; Wang, Y; Zhou, H1
Bayin, NS; Placantonakis, DG1
Ding, JS; Yang, YJ1
Chang, H; Dong, H; Lu, H; Meng, X; Zhang, K; Zhang, X; Zhang, Y1
Chen, Z; Cui, L; Li, Y; Long, M; Lu, A; Zhu, L1
Baker, JHE; Kozlowski, P; Minchinton, AI; Moosvi, F; Reinsberg, SA; Yung, A1
Shimizu, Y1
Cao, J; Hong, H; Kung, HF; Liu, Y; Qiao, J; Yao, X; Zha, Z; Zhang, A; Zhang, L; Zhang, Y; Zhao, R; Zhu, L1
Bohlander, SK; Devaux, JBL; Hart, CP; Hickey, AJR; Hong, CR; Hunter, FW; Kakadia, PM; Ketela, TW; Khan, A; Marastoni, S; Meng, F; Print, CG; Shalev, Z; Sharma, I; Tsai, P; Wilson, WR; Wouters, BG1
Kosaka, M; Sakai-Sawada, K; Takei, N; Tamura, Y; Yoneda, A1
Aguirre, A; Kuhn, L; Mohammad, I; Smith, MB; Wang, T; Xu, Y; Yang, Y; Zanganeh, S; Zhu, Q1
Ashoorzadeh, A; Ding, K; Guise, CP; Lin, WH; Mowday, AM; Patterson, AV; Smaill, JB; Wu, DH; Yuan, R1
Lü, HX; Pang, H; Wang, WQ; Zhang, ZH; Zhou, JP1
Hara, D; Ito, T; Kawasaki, A; Son, A; Tanabe, K1
Baldry, C; Blower, PJ; Domarkas, J; Fleming, IN; Gilbert, FJ; Harris, AL; Lord, S; Manavaki, R; West, C; Williams, KJ1
Dubois, L; Lambin, P; Peeters, SG; Van Elmpt, W; Yaromina, A; Zegers, CM1
Brindell, M; Kieda, C; Mazuryk, O; Suzenet, F1
Bukala, D; Eichner, M; Feger, M; Fuchs, K; Harant, M; Kneilling, M; Lang, F; Mahling, M; Maier, FC; Pichler, BJ; Reischl, G; Reutershan, J; Thaiss, WM1
Aung, W; Endo, H; Fujibayashi, Y; Furukawa, T; Hasegawa, S; Inoue, M; Jin, ZH; Saga, T; Yoshii, Y; Yuan, Q; Zhang, MR1
Chen, LW; Duan, YT; Tang, DJ; Tao, XX; Wang, PF; Xu, C; Yang, MR; Zhu, HL1
Bahce, I; Boellaard, R; de Langen, AJ; Hoekstra, OS; Huisman, MC; Iqbal, R; Kramer, GM; Lammertsma, AA; van Velden, FH; Verwer, EE; Windhorst, AD1
Yoshimoto, M1
Cabrales, P; Minchinton, A; Oronsky, B; Scicinski, J1
Hisano, H; Ikeda, Y; Nagasaki, Y; Nishikawa, Y1
Bacchu, V; Elsaidi, HR; Kumar, P; Laurens, E; Wang, M; Wiebe, LI; Yang, J; Zorniak, B1
Krohn, KA; Link, JM; Mason, RP1
Busk, M; Bussink, J; Horsman, MR; Jakobsen, S; Overgaard, J; van der Kogel, A1
Banerjee, S; Mallia, MB; Mathur, A; Sarma, HD; Subramanian, S; Venkatesh, M1
Chen, Q; Deng, X; He, F; Huang, Y; Li, GC; Ling, CC; Liu, Y; Minami, A; Sun, X; Wen, B; Xing, L; Zanzonico, PB1
Eskola, O; Grönroos, TJ; Komar, G; Lehtiö, K; Minn, H; Seppänen, M; Solin, O; Tuomela, J1
Bestetti, RB; Theodoropoulos, TA1
Abrams, DN; Kumar, P; McEwan, AJ; Postema, EJ; Riauka, TA; Richmond, DA; Wiebe, LI1
Kizaka-Kondoh, S; Konse-Nagasawa, H1
Bennewith, KL; Cairns, RA; Chang, DT; Denko, NC; Giaccia, AJ; Graves, EE1
Humm, JL; Li, XF; Ling, CC; Ma, Y; O'Donoghue, JA; Russell, J; Suehiro, M; Sun, X; Zhang, M1
Campbell, MJ; Cross, K; Eaton, D; Halbert, G; Judson, I; Leach, MO; Lee, CP; McNamara, J; Oregioni, A; Payne, GS; Raynaud, FI; Ruddle, R; Seddon, B; Tan, S; Tracy, M; Workman, P1
Möller, A; Young, RJ1
Bol, A; Christian, N; De Bast, M; Deheneffe, S; Grégoire, V; Labar, D; Lee, JA1
Aerts, HJ; Brans, B; De Ruysscher, D; Dingemans, AM; Dubois, L; Hochstenbag, M; Janssen, MH; Kolb, H; Lalisang, R; Lambin, P; Ollers, M; van Dongen, GA; van Loon, J; Windhorst, B; Zhang, J1
Busch, TM1
Baumann, M; Beuthien-Baumann, B; Bussink, J; Eicheler, W; Krause, M; Rijken, P; Santiago, A; van der Kogel, AJ; Yaromina, A1
Busk, M; Horsman, MR; Jakobsen, S; Munk, OL; Overgaard, J; Skals, M; Steiniche, T; Wang, T1
Cerecetto, H; Fernández, S; Giglio, J; Rey, A1
Chitneni, SK; Dewhirst, MW; Palmer, GM; Zalutsky, MR1
Carreau, A; El Hafny-Rahbi, B; Grillon, C; Kieda, C; Matejuk, A1
Bouvet, VR; Wiebe, LI; Wuest, F; Wuest, M1
Bendell, JC; Borad, MJ; Burris, HA; Chiorean, EG; Infante, JR; Jones, SF; Kroll, S; Lacouture, ME; Langmuir, VK; Lee, H; Lewandowski, K; Molina, JR; Ramanathan, RK; Tibes, R; Weiss, GJ1
Aki, H; Fukumura, T; Furutsuka, K; Hayashi, K; Muto, M; Nakao, R; Suzuki, K; Takei, M1
Astner, ST; Bayer, C; Maftei, CA; Shi, K; Vaupel, P1
Liu, K; Zhu, HL1
Aguirre, A; Biswal, NC; Claffey, KP; Kuhn, LT; Pavlik, C; Smith, MB; Xu, Y; Zanganeh, S; Zhu, Q1
Hammerschmidt, F; Schweifer, A1
Anderson, RF; Banica, M; Bhupathi, D; Cai, X; Duan, JX; Evans, JW; Glazer, PM; Guise, CP; Hart, CP; Lan, L; Lorente, G; Maroz, A; Matteucci, MD; Meng, F; Mowday, AM; Patterson, AV; Stachelek, GC1
Sharma, R2
Kadonosono, T; Kizaka-Kondoh, S; Nagasawa, H; Okabe, Y; Okuda, K; Ueno, T; Youssif, BG1
Hayallah, AA; Hussein, MA; Kadonosono, T; Kizaka-Kondoh, S; Nagasawa, H; Okuda, K; Salem, OI; Youssif, BG1
Moyer, MW1
Cerecetto, H; Fernández, S; Giglio, J; Rey, AM1
Cheeseman, C; Khlebnikov, V; Kumar, P; Liang, H; Shustov, G; Wiebe, LI; Yang, XH; Zheng, W1
Ali, MS; Kohanim, S; Kong, FL; Mendez, R; Rollo, A; Smith, DL; Yang, DJ1
Hoigebazar, L; Jeong, JM1
Cooper, ME; Gjertsen, BT; Haug, BE; Lorens, JB; McCormack, E; Micklem, DR; Pavlin, T; Silden, E; West, RM1
Broggini-Tenzer, A; Hug, D; Orlowski, K; Pruschy, M; Rohrer Bley, C; Soltermann, A; Vuong, V; Zimmermann, M1
Bergman, J; Eskola, O; Kulmala, J; Lehtiö, K; Minn, H; Oikonen, V; Tolvanen, T1
Evans, SM; Koch, CJ1
Begg, AC1
Grimshaw, R; Halbert, G; Judson, I; Leach, MO; Payne, GS; Raynaud, F; Ruddle, R; Seddon, BM; Simmons, L; Tan, S; Turner, A; Workman, P1
Frischer, JS; Holash, J; Huang, J; Kadenhe-Chiwishe, A; Kandel, JJ; Kim, ES; Lee, A; New, T; Pollyea, DA; Serur, A; Yamashiro, DJ; Yancopoulos, GD; Yokoi, A1
Mechetner, E; Samoszuk, MK; Walter, J1
Aquino-Parsons, C; Olive, PL1
Griffiths, JR; Robinson, SP1
Ito, M; Ogino, H; Shibamoto, Y; Sugie, C1
Seddon, BM; Workman, P1
Beck, R; Kumar, P; Machulla, HJ; McEwan, AJ; Picchio, M; Piert, M; Reischl, G; Schwaiger, M; Wester, HJ; Wiebe, LI; Ziegler, S1
Burgman, P; Burnazi, E; Cai, S; Finn, RD; Humm, JL; Lewis, JS; Ling, CC; O'Donoghue, JA; Pugachev, A; Ruan, S; Smith-Jones, P; Welch, MJ; Wen, B; Zanzonico, P1
Campa, J; Carlin, S; Humm, JL; Larson, SM; Ling, CC; Pugachev, A; Ruan, S1
Kumar, P; McEwan, AJ; Naimi, E; Wiebe, LI1
Begg, AC; Bussink, J; Kaanders, JH; Ljungkvist, AS; Raleigh, JA; Rijken, PF; van der Kogel, AJ1
Aquino-Parsons, C; Olive, P; Sobhanifar, S; Stanbridge, EJ1
Chou, SC; Ji, X; Kleiter, MM; Lee, DY; Malarkey, DE; Raleigh, JA; Thrall, DE1
Fernández-Braña, M1
Parker, CA; Stratford, IJ; Williams, KJ1
Boerman, OC; Bussink, J; Kaanders, JH; Laverman, P; Lok, J; Oyen, WJ; Philippens, M; Troost, EG; van der Kogel, AJ1
Banerjee, S; Mallia, MB; Sarma, HD; Subramanian, S; Venkatesh, M1
Burgman, P; Chen, Q; Diaz-Gonzalez, JA; Li, XF; Ling, CC; Russell, J; Shin, KH1
Caetano, PK; Calvi, SA; de Carvalho, TB; Lima, CR; Machado, JM; Nagoshi, LR; Persi, E; Picka, MM; Ribeiro, DA; Salvadori, DM1
Bol, A; Christian, N; De Bast, M; Grégoire, V; Labar, D; Lee, J; Mahy, P1
Eykyn, TR; Gabellieri, C; Leach, MO1
Binns, D; Cullinane, C; Dorow, DS; Hicks, RJ; Katsifis, A; Reischl, G; Roselt, P1
Eschmann, SM; Langen, KJ1
Brown, JM2
Adams, GE4
Coleman, CN; Phillips, TL; Urtasun, RC; Wasserman, TH1
Denekamp, J; Fowler, JF; Williams, MV1
Coleman, CN; Halsey, J; Hancock, S; Harris, JW; Hirst, VK; Urtasun, RC; Wasserman, TH1
Phillips, TL2
Chu, FC; Kim, JH1
Onoyama, Y1
Dische, S2
Siemann, DW1
Brown, JM; White, RA; Workman, P1
Fulton, DS; Raleigh, J; Tanasichuk, H; Urtasun, RC1
Bleehen, NM; Lee, FY; Roberts, JT; Walton, MI; Workman, P1
Bleehen, NM; Roberts, JT; Walton, MI; Workman, P2
Anderson, PJ; Bennett, MH; Dische, S; Minchinton, A; Saunders, MI; Stratford, MR; Tothill, M1
Overgaard, J; Overgaard, M; Timothy, AR2
Okajima, S; Okumura, Y1
Abe, Y; Hong, SS; Kaneta, K; Matsuzawa, T1
Allen, JG; Dische, S; Lenox-Smith, I; Malcolm, SL; Saunders, MI1
Chapman, JD; Jette, DC; Wiebe, LI1
Denekamp, J; Fowler, JF; Hill, SA; Minchinton, AI; Stratford, MR1
Abe, Y; Hong, SS; Isobe, Y; Kaneta, K; Kawaguchi, T; Matsuzawa, T; Umegaki, Y; Yamakawa, M1
Abe, M; Dodo, Y; Ono, K; Takahashi, M1
Abe, M; Hiraoka, M; Ono, K; Takahashi, M1
Groves, JK; Lee, A; Malcolm, SL1
Carter, SK; Coleman, CN; Friedman, MK; Gribble, M; Halsey, J; Hirst, VK; Ignoffo, R; Jacobs, C; Leibel, S; Phillips, TL1
Adams, GE; Ahmed, I; Clarke, ED; O'Neill, P; Parrick, J; Stratford, IJ; Wallace, RG; Wardman, P; Watts, ME1
Nakatsugawa, S; Sugahara, T1
Edwards, DI1
Phillips, TL; VanRaalte, G; Wasserman, TH1
Allen, JG; Bishop, A; Dische, S; Fermont, D; Lenox-Smith, I; Malcolm, SL; Saunders, MI1
Gangji, D; Schwade, JG; Strong, JM1
Gangji, D; Schwade, JG; Shoemaker, DD; Strong, JM; Upton, DK1
Phillips, TL; Stetz, J; Wasserman, TH1
Bennett, MH; Dische, S; Hauck, J; Minchinton, AI; Riley, PJ; Saunders, MI; Stratford, MR1
Ash, DV; Smith, MR1
White, RA; Workman, P1
Adams, GE; Ahmed, I; Fielden, EM; O'Neill, P; Stratford, IJ1
Denekamp, J; Fowler, JF; Joiner, MC; McNally, NJ1
Workman, P1
Cooper, JS; Waltzman, SB1
Overgaard, J2
Hodgkiss, RJ; Mehta, LK; Monney, H; Parrick, J1
Cline, JM; Raleigh, JA; Rosner, GL; Thrall, DE2
Adams, GE; Stratford, IJ2
Cline, JM; La Dine, JK; Raleigh, JA; Thrall, DE1
Laster, BH; Metzger, RL; Swenson, DH1
Langmuir, VK1
Cowan, DS; Hicks, KO; Wilson, WR1
Chapman, JD; Mannan, RH; McEwan, AJ; Mercer, JR; Morin, C; Parliament, MB; Urtasun, RC; Wiebe, LI1
Ballinger, JR; Cowan, DS; Melo, T; Park, L; Rauth, AM1
Cherif, A; Harrod, VL; Inoue, T; Kim, CG; Kim, EE; Kuang, LR; Newman, RA; Nornoo, A; Podoloff, DA; Wallace, S; Yang, DJ1
Bestetti, RB1
Tocher, JH1
Azuma, C; Raleigh, JA; Thrall, DE1
Azuma, C; McEntee, MC; Raleigh, JA; Rosner, GL; Thrall, DE1
Bellotti, G; Bocchi, EA; Fiorelli, A; Higuchi, ML; Jatene, A; Pileggi, F; Stolf, N; Uip, D; Vieira, ML1
Durand, RE; Raleigh, JA1
Hodgkiss, RJ1
Aboagye, EO; Kelson, AB; Tracy, M; Workman, P1
Lehnert, S1
Ballinger, JR1
Aquino-Parsons, C; Banáth, JP; Olive, PL1
Denny, WA1
Bonn, D1
Adams, GE; Dische, S; Fowler, JF; Thomlinson, RH1
Karim, AB1
Kärcher, KH; Kogelnik, HD; Seitz, W; Szepesi, T1
Chapman, JD; Urtasun, RC1
Fowler, JF1
Anderson, P; Dische, S; Flockhart, IR; Saunders, ME1
Band, RP; Chapman, JD; Feldstein, ML; Marynowski, B; Rabin, HR; Shnitka, T; Starreveld, E; Urtasun, RC; Wilson, AF1
Dische, S; Flockhart, IR; Saunders, MI1
Gomer, CJ; Johnson, RJ; Lawrence, GA; Levin, VA; Marques, RA; Phillips, TL; Sadee, W; VanRaalte, G; Wasserman, TH1
Anderson, P; Dische, S; Flockhart, IR; Lee, ME; Saunders, MI1
Kogelnik, HD; Mamoli, B; Müller, M; Rathkolb, O; Wessely, P1
Bahnemann, D; Basaga, H; Dunlop, JR; Searle, AJ; Willson, RL1
Flockhart, IR; Malcolm, SL; Marten, TR; Parkins, CS; Ruane, RJ; Troup, D1
Gomer, CJ; Lawrence, GA; Levine, ML; Penta, JS; Phillips, TL; Rubin, DJ; Sadee, W; Wasserman, TH1
Dische, S; Saunders, MI1
Bleehen, NM; Owen, LN; White, RA; Workman, P1
Bataini, JP; Bernier, J; Brugère, J; Brunin, F; de Narbonne, J; Jaulerry, C1
Munzenrider, JE1
Ash, DV; Bugden, RD; Smith, MR1
Hellmann, K1
Denekamp, J; Flockhart, IR; McNally, NJ; Sheldon, PW1
Coulter, JR; Turner, JV1
Bleehen, NM; Plowman, PN; Wiltshire, CR; Workman, P1
Band, P; Chapman, JD; Fryer, CG; Rabin, HR; Urtasun, RC; Wilson, AF1
Hofer, KG; Hofer, MG; Ieracitano, J; McLaughlin, WH1
Adams, GE; Dische, S; Flockhart, IR; Lee, ME; Saunders, MI1
Daneau, D; Husson, M; Klastersky, J; Weerts-Ruhl, D1
Adams, GE; Denekamp, J; Fowler, JF1
Dische, S; Gray Errington, L; Thomlinson, RH1
Stratford, MR1
Chapman, JD; Golberg, L; Mannan, RH; McEwan, AJ; Mercer, JR; Parliament, MB; Urtasun, RC; Wiebe, LI1
Cline, JM; LaDine, JK; Raleigh, JA; Rathman, M; Thrall, DE; Zeman, EM1
Stratford, IJ1
Alexander, E; Buswell, L; Coleman, CN; Harris, JR; Howes, AE; Kramer, RA; Loeffler, JS; Noll, L; Riese, N; Wen, P1
Frei, E; Teicher, BA1
Cline, JM; Franko, AJ; Page, RL; Raleigh, JA; Thrall, DE1
Brown, TD; Burris, HA; Havlin, KA; O'Rourke, TJ; Rodriguez, GI; Wall, JG; Weiss, GR1
Bleehen, NM; Maughan, TS; Newman, HF; Stenning, S; Ward, R; Workman, P1
Adams, GE; Bremner, JC; Edwards, HS; Fielden, EM; Stratford, IJ1
Anders, MW1
Bleehen, NM; Maughan, TS; Newman, HF; Ward, R; Workman, P1
Coleman, CN; Halsey, J; Hancock, S; Noll, L; Phillips, TL; Urtasun, RC; Wasserman, TH1
Coleman, CN; Harris, JR; Howes, AE; Kramer, RA; Noll, L; Zakar, J1
Bleehen, NM; Maughan, TS; Newman, HF; Workman, P1
Best, MW; Franko, AJ; Koch, CJ; Miller, GG; Raleigh, JA1
Coleman, CN2
Evans, WK; Stewart, DJ1
Bennett, MH; Dische, S; Orchard, R; Stratford, MR; Wardman, P1
Bleehen, NM; Newman, HF; Workman, P1
Bennett, MH; Des Rochers, C; Dische, S; Dunphy, EP; Minchinton, AI; Orchard, RA; Saunders, MI; Stratford, MR1
Wasserman, TH1
Bleehen, NM; Newman, HF; Ward, R; Workman, P1
Mulcahy, RT1
DeGraff, W; Gamson, J; McPherson, S; Mitchell, JB; Russo, A; Zabell, A1
Hall, EJ1
Cossu, F; Facchini, A; Mazza, S; Rombi, GP1
Roe, FJ1
Gonzalez, DG; Maes, RA; Meering, PG; van Peperzeel, HA1

Reviews

52 review(s) available for azomycin and Neoplasms

ArticleYear
Imaging hypoxia and angiogenesis in tumors.
    Radiologic clinics of North America, 2005, Volume: 43, Issue:1

    Topics: Cell Hypoxia; Humans; Neoplasms; Neovascularization, Pathologic; Nitroimidazoles; Radionuclide Imaging

2005
Hypoxia and its therapeutic possibilities in paediatric cancers.
    British journal of cancer, 2021, Volume: 124, Issue:3

    Topics: Antineoplastic Agents; Biomarkers; Carbonic Anhydrase IX; Cell Hypoxia; Child; Combined Modality Therapy; Glucose Transporter Type 1; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Magnetic Resonance Imaging; Neoplasms; Nitroimidazoles; Oxygen Consumption; Prodrugs; Tumor Hypoxia; Vascular Endothelial Growth Factor A

2021
[Progress in study of nitroimidazole as hypoxia imaging agents in tumor].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2016, Volume: 51, Issue:8

    Topics: Animals; Humans; Hypoxia; Neoplasms; Nitroimidazoles; Radionuclide Imaging

2016
[Accumulation Mechanism of 2-Nitroimidazole-based Hypoxia Imaging Probes Revealed by Imaging Mass Spectrometry].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2018, Volume: 138, Issue:11

    Topics: Animals; Glutathione; Glutathione Transferase; Humans; Hypoxia; Mass Spectrometry; Mice; Misonidazole; Molecular Imaging; Molecular Probes; Multidrug Resistance-Associated Proteins; Neoplasms; Nitroimidazoles; Positron-Emission Tomography

2018
Bioreductive prodrugs as cancer therapeutics: targeting tumor hypoxia.
    Chinese journal of cancer, 2014, Volume: 33, Issue:2

    Topics: Anthraquinones; Antineoplastic Agents; Aziridines; Cell Hypoxia; Humans; Indolequinones; Molecular Structure; NAD(P)H Dehydrogenase (Quinone); Neoplasms; Nitrogen Mustard Compounds; Nitroimidazoles; Phosphoramide Mustards; Prodrugs; Tirapazamine; Triazines

2014
[An overview of glycoconjugates for cancer targeting therapy and diagnosis].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2013, Volume: 48, Issue:12

    Topics: Animals; Antineoplastic Agents; Drug Carriers; Energy Metabolism; Glucose; Glycoconjugates; Glycolysis; Glycosides; Humans; Ifosfamide; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents

2013
Imaging tumour hypoxia with positron emission tomography.
    British journal of cancer, 2015, Jan-20, Volume: 112, Issue:2

    Topics: Cell Hypoxia; Humans; Neoplasms; Nitroimidazoles; Positron-Emission Tomography; Radiopharmaceuticals; Radiotherapy Planning, Computer-Assisted

2015
Current preclinical and clinical applications of hypoxia PET imaging using 2-nitroimidazoles.
    The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of..., 2015, Volume: 59, Issue:1

    Topics: Animals; Cell Hypoxia; Evidence-Based Medicine; Humans; Molecular Imaging; Neoplasms; Nitroimidazoles; Oxygen; Positron-Emission Tomography; Radiopharmaceuticals

2015
[Current Status and Prospects on PET Radiopharmaceuticals for Radiotherapy].
    Igaku butsuri : Nihon Igaku Butsuri Gakkai kikanshi = Japanese journal of medical physics : an official journal of Japan Society of Medical Physics, 2015, Volume: 35, Issue:1

    Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Coordination Complexes; Fluorine Radioisotopes; Humans; Hypoxia; Misonidazole; Neoplasms; Nitroimidazoles; Organometallic Compounds; Phenylalanine; Positron-Emission Tomography; Radiopharmaceuticals; Thiosemicarbazones

2015
Molecular imaging of hypoxia.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2008, Volume: 49 Suppl 2

    Topics: Animals; Cell Hypoxia; Coordination Complexes; Electron Spin Resonance Spectroscopy; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Neoplasms; Neovascularization, Pathologic; Nitroimidazoles; Organometallic Compounds; Oximetry; Oxygen; Positron-Emission Tomography; Radiopharmaceuticals; Thiosemicarbazones

2008
Imaging of tumor hypoxia to predict treatment sensitivity.
    Current pharmaceutical design, 2008, Volume: 14, Issue:28

    Topics: Animals; Cell Hypoxia; Drug Resistance, Neoplasm; Etanidazole; Humans; Hydrocarbons, Fluorinated; Neoplasms; Nitroimidazoles; Positron-Emission Tomography; Radiopharmaceuticals

2008
A systematic review of studies on heart transplantation for patients with end-stage Chagas' heart disease.
    Journal of cardiac failure, 2009, Volume: 15, Issue:3

    Topics: Allopurinol; Chagas Disease; Graft Rejection; Heart Transplantation; Humans; Immunosuppressive Agents; Neoplasms; Nitroimidazoles; Perioperative Care; Postoperative Complications; Recurrence; Trypanocidal Agents

2009
Significance of nitroimidazole compounds and hypoxia-inducible factor-1 for imaging tumor hypoxia.
    Cancer science, 2009, Volume: 100, Issue:8

    Topics: Animals; Cell Hypoxia; Diagnostic Imaging; Humans; Hypoxia-Inducible Factor 1; Neoplasms; Nitroimidazoles; Oxygen

2009
Molecular imaging of hypoxia.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2011, Volume: 52, Issue:2

    Topics: Humans; Hypoxia; Misonidazole; Neoplasms; Neovascularization, Pathologic; Nitroimidazoles; Positron-Emission Tomography; Radiography; Radiopharmaceuticals

2011
Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia.
    Journal of cellular and molecular medicine, 2011, Volume: 15, Issue:6

    Topics: Animals; Biomarkers; Cell Hypoxia; Erythrocytes; Humans; Hypoxia; Magnetic Resonance Spectroscopy; Mammals; Molecular Imaging; Neoplasms; Nitroimidazoles; Oxygen; Partial Pressure; Polarography; Positron-Emission Tomography; Small Molecule Libraries

2011
Nitroimidazoles as anti-tumor agents.
    Anti-cancer agents in medicinal chemistry, 2011, Volume: 11, Issue:7

    Topics: Animals; Antineoplastic Agents; Biotransformation; Humans; Hypoxia; Neoplasms; Nitroimidazoles; Oxidation-Reduction; Oxygen; Prodrugs; Radiation-Sensitizing Agents; Tumor Cells, Cultured

2011
Nitroimidazole radiopharmaceuticals in bioimaging: part I: synthesis and imaging applications.
    Current radiopharmaceuticals, 2011, Volume: 4, Issue:4

    Topics: Animals; Cell Hypoxia; Clinical Trials as Topic; Humans; Isotope Labeling; Magnetic Resonance Imaging; Myocardial Ischemia; Neoplasms; Nitroimidazoles; Radionuclide Imaging; Radiopharmaceuticals

2011
Nitroimidazole radiopharmaceuticals in hypoxia: part II cytotoxicity and radiosensitization applications.
    Current radiopharmaceuticals, 2011, Volume: 4, Issue:4

    Topics: Animals; Apoptosis; Cell Hypoxia; Combined Modality Therapy; DNA; Humans; Neoplasms; Nitroimidazoles; Phagocytosis; Radiation-Sensitizing Agents; Radiopharmaceuticals

2011
Hypoxia imaging agents labeled with positron emitters.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 2013, Volume: 194

    Topics: Animals; Cell Hypoxia; Copper Radioisotopes; Fluorine Radioisotopes; Humans; Neoplasms; Nitroimidazoles; Positron-Emission Tomography; Radiopharmaceuticals

2013
Prognostic significance of tumor oxygenation in humans.
    Cancer letters, 2003, May-30, Volume: 195, Issue:1

    Topics: Animals; Biomarkers; Case Management; Cell Hypoxia; Energy Metabolism; Humans; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms; Nitroimidazoles; Oximetry; Oxygen; Oxygen Consumption; Partial Pressure; Prognosis; Radiopharmaceuticals; Rodentia; Tomography, Emission-Computed

2003
A phase I study of SR-4554 via intravenous administration for noninvasive investigation of tumor hypoxia by magnetic resonance spectroscopy in patients with malignancy.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Nov-01, Volume: 9, Issue:14

    Topics: Adult; Aged; Biomarkers, Tumor; Chromatography, High Pressure Liquid; Female; Fluorine Radioisotopes; Half-Life; Humans; Hypoxia; Infusions, Intravenous; Magnetic Resonance Spectroscopy; Male; Maximum Tolerated Dose; Metabolic Clearance Rate; Middle Aged; Neoplasms; Nitroimidazoles

2003
Measurement of tumor hypoxia using single-cell methods.
    Seminars in radiation oncology, 2004, Volume: 14, Issue:3

    Topics: Antigens, Neoplasm; Biomarkers, Tumor; Carbonic Anhydrase IX; Carbonic Anhydrases; Cell Hypoxia; Glucose Transporter Type 1; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Monosaccharide Transport Proteins; Neoplasms; Nitroimidazoles; Oxygen Consumption; Transcription Factors

2004
Current issues in the utility of 19F nuclear magnetic resonance methodologies for the assessment of tumour hypoxia.
    Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2004, Jun-29, Volume: 359, Issue:1446

    Topics: Fluorine; Fluorocarbons; Humans; Hypoxia; Magnetic Resonance Spectroscopy; Neoplasms; Nitroimidazoles; Oximetry

2004
The Japanese experiences with hypoxia-targeting pharmacoradiotherapy: from hypoxic cell sensitisers to radiation-activated prodrugs.
    Expert opinion on pharmacotherapy, 2004, Volume: 5, Issue:12

    Topics: Asian People; Cell Hypoxia; Clinical Trials as Topic; Humans; Imidazoles; Neoplasms; Nitroimidazoles; Prodrugs; Radiation; Radiation-Sensitizing Agents; Tirapazamine; Triazines

2004
The role of functional and molecular imaging in cancer drug discovery and development.
    The British journal of radiology, 2003, Volume: 76 Spec No 2

    Topics: Antineoplastic Agents; Benzoquinones; Diagnostic Imaging; HSP90 Heat-Shock Proteins; Humans; Hypoxia; Lactams, Macrocyclic; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Neoplasms; Nitroimidazoles; Positron-Emission Tomography; Rifabutin; Technology, Pharmaceutical; Ultrasonography

2003
Exogenous and endogenous markers of tumour oxygenation status: definitive markers of tumour hypoxia?
    Advances in experimental medicine and biology, 2005, Volume: 566

    Topics: Antigens, Neoplasm; Biomarkers; Carbonic Anhydrase IX; Carbonic Anhydrases; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Neoplasms; Nitroimidazoles; Oxygen

2005
Clinical trials with hypoxic cell sensitizers: time to retrench or time to push forward?
    International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:9

    Topics: Clinical Trials as Topic; Combined Modality Therapy; Dexamethasone; Drug Evaluation; Etanidazole; Humans; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents

1984
Sensitizers and protectors in clinical oncology.
    Seminars in oncology, 1981, Volume: 8, Issue:1

    Topics: Alkylating Agents; Amifostine; Animals; Drug Synergism; Humans; Mice; Misonidazole; Neoplasms; Neoplasms, Experimental; Nitroimidazoles; Organothiophosphorus Compounds; Radiation-Protective Agents; Radiation-Sensitizing Agents

1981
Chemical radiation sensitizers and protectors: recent developments.
    Clinical bulletin, 1981, Volume: 11, Issue:1

    Topics: Amifostine; Cysteamine; Cysteine; DNA, Neoplasm; Humans; Neoplasms; Nitroimidazoles; Nucleic Acid Conformation; Oxygen; Radiation-Protective Agents; Radiation-Sensitizing Agents; Sulfhydryl Compounds

1981
Modification of chemotherapy by nitroimidazoles.
    International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:9

    Topics: Animals; Antineoplastic Agents; Cyclophosphamide; DNA Repair; Drug Synergism; Glutathione; Lomustine; Melphalan; Mice; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Time Factors

1984
[Cancer and radiotherapy. (4). Hypoxic cell sensitizers and hyperthermia combined with radiation in cancer treatment].
    Iyo denshi to seitai kogaku. Japanese journal of medical electronics and biological engineering, 1982, Volume: 20, Issue:3

    Topics: Acetophenones; Animals; Hot Temperature; Humans; Mice; Misonidazole; Neoplasms; Nitrofurans; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents

1982
Radiation sensitization studies in Japan.
    Cancer treatment reviews, 1981, Volume: 8, Issue:1

    Topics: Animals; Cell Survival; Drug Evaluation; Half-Life; Humans; Japan; Mice; Mice, Inbred C3H; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents

1981
Mechanisms of cytotoxicity of nitroimidazole drugs.
    Progress in medicinal chemistry, 1981, Volume: 18

    Topics: Animals; Bacteria; Cell Survival; DNA; Drug Interactions; Drug Resistance; Humans; Neoplasms; Nitroimidazoles; Photosynthesis; Radiation-Sensitizing Agents; Structure-Activity Relationship; Sulfhydryl Compounds

1981
Clinical evaluation of nitroimidazoles as modifiers of hypoxia in solid tumors.
    Oncology research, 1994, Volume: 6, Issue:10-11

    Topics: Antineoplastic Agents; Cell Hypoxia; Humans; Neoplasms; Nitroimidazoles; Oxygen; Randomized Controlled Trials as Topic

1994
The use of radioimmunotherapy in combination with bioreductive agents.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1996, Volume: 141

    Topics: Antineoplastic Agents; Combined Modality Therapy; Cytotoxins; Humans; Immunoconjugates; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents; Radioimmunotherapy; Triazines

1996
Reductive activation of nitroheterocyclic compounds.
    General pharmacology, 1997, Volume: 28, Issue:4

    Topics: Anti-Bacterial Agents; Antineoplastic Agents; Bacteria, Anaerobic; Bacterial Infections; Biotransformation; Humans; Mutagens; Neoplasms; Nitrofurans; Nitroimidazoles; Oxidation-Reduction

1997
Use of 2-nitroimidazoles as bioreductive markers for tumour hypoxia.
    Anti-cancer drug design, 1998, Volume: 13, Issue:6

    Topics: Animals; Biomarkers; Cell Division; Cell Hypoxia; Flow Cytometry; Humans; Neoplasms; Nitroimidazoles; Oxidation-Reduction

1998
Preclinical development and current status of the fluorinated 2-nitroimidazole hypoxia probe N-(2-hydroxy-3,3,3-trifluoropropyl)-2-(2-nitro-1-imidazolyl) acetamide (SR 4554, CRC 94/17): a non-invasive diagnostic probe for the measurement of tumor hypoxia
    Anti-cancer drug design, 1998, Volume: 13, Issue:6

    Topics: Animals; Cell Hypoxia; Humans; Magnetic Resonance Spectroscopy; Molecular Probes; Neoplasms; Nitroimidazoles; Tomography, Emission-Computed

1998
Imaging hypoxia in tumors.
    Seminars in nuclear medicine, 2001, Volume: 31, Issue:4

    Topics: Animals; Cell Hypoxia; Copper Radioisotopes; Fluorine Radioisotopes; Humans; Iodine Radioisotopes; Neoplasms; Nitroimidazoles; Radionuclide Imaging; Radiopharmaceuticals; Technetium; Technetium Compounds

2001
The role of hypoxia-activated prodrugs in cancer therapy.
    The Lancet. Oncology, 2000, Volume: 1, Issue:1

    Topics: Animals; Antineoplastic Agents; Cell Hypoxia; Humans; Neoplasms; Nitroimidazoles; Oxides; Prodrugs; Quinones

2000
Chemical modification of radiation effects.
    Cancer, 1977, Volume: 39, Issue:2 Suppl

    Topics: Animals; Antineoplastic Agents; Bromodeoxyuridine; Cell Survival; Cysteamine; DNA; Drug Evaluation; Drug Interactions; Humans; Hypoxia; Metronidazole; Neoplasms; Neoplasms, Experimental; Nitroimidazoles; Radiation Effects; Radiation-Protective Agents; Radiation-Sensitizing Agents

1977
Recent advances in radiotherapy.
    Revista interamericana de radiologia, 1977, Volume: 2, Issue:3

    Topics: Breast Neoplasms; Bromodeoxyuridine; Carcinoid Tumor; Elementary Particles; Fast Neutrons; Hot Temperature; Humans; Male; Melanoma; Metronidazole; Neoplasms; Nitroimidazoles; Pancreatic Neoplasms; Prostatic Neoplasms; Protons; Radiation Protection; Radiation Tolerance; Radiation-Sensitizing Agents; Radioisotopes; Radiotherapy Dosage; Radiotherapy, High-Energy; Rectal Neoplasms; Salivary Gland Neoplasms; Sarcoma; Soft Tissue Neoplasms

1977
Pharmacokinetics and subcellular localization of radiosensitizers.
    BJR supplement, 1992, Volume: 24

    Topics: Etanidazole; Humans; Hydrogen-Ion Concentration; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents

1992
Bioreductive drugs in cancer therapy.
    BJR supplement, 1992, Volume: 24

    Topics: Animals; Antineoplastic Agents; Antioxidants; Cell Hypoxia; Humans; Misonidazole; Neoplasms; Nitroimidazoles; Prodrugs; Radiation-Sensitizing Agents; Tirapazamine; Triazines

1992
Modulation of antitumor alkylating agents (AA).
    Cancer treatment and research, 1991, Volume: 57

    Topics: Alkylating Agents; Antineoplastic Agents; Cell Hypoxia; Cisplatin; DNA Damage; DNA Repair; Drug Combinations; Drug Interactions; Drug Resistance; Fluorocarbons; Glutathione; Glutathione Transferase; Humans; Hydroxyethyl Starch Derivatives; Indazoles; Metallothionein; Neoplasm Proteins; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Topoisomerase II Inhibitors; Xanthines

1991
New anticancer agents.
    Cancer chemotherapy and biological response modifiers, 1991, Volume: 12

    Topics: Alkaloids; Animals; Antineoplastic Agents; Azacitidine; Biphenyl Compounds; Chrysenes; Deoxycytidine; Echinomycin; Epirubicin; Etanidazole; Flavonoids; Gemcitabine; Guanidines; Humans; Idarubicin; Menogaril; Mitoguazone; Neoplasms; Nitroimidazoles; Nogalamycin; Organoplatinum Compounds; Paclitaxel; Pentostatin; Polymers; Propylene Glycols; Ribavirin; Sulfonylurea Compounds; Trimetrexate; Vidarabine Phosphate

1991
Glutathione-dependent bioactivation of xenobiotics: implications for mutagenicity and carcinogenicity.
    Princess Takamatsu symposia, 1990, Volume: 21

    Topics: Animals; Antineoplastic Agents; Cysteine; DNA; DNA Damage; Glutathione; Mice; Mutagenesis; Neoplasms; Nitroimidazoles; Rats; Xenobiotics

1990
Modification of radiotherapy by radiosensitizers and cancer chemotherapy agents. I. Radiosensitizers.
    Seminars in oncology, 1989, Volume: 16, Issue:3

    Topics: Antineoplastic Agents; Bromodeoxyuridine; Combined Modality Therapy; Glutathione; Humans; Idoxuridine; Interleukin-1; Neoplasms; Nitroimidazoles; Oxidation-Reduction; Oxygen; Radiation-Protective Agents; Radiation-Sensitizing Agents

1989
Non-chemotherapeutic agents that potentiate chemotherapy efficacy.
    Cancer treatment reviews, 1989, Volume: 16, Issue:1

    Topics: Adult; Amphotericin B; Animals; Antimetabolites; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Calcium Channel Blockers; Calmodulin; Cardiotonic Agents; Child; Clinical Trials as Topic; Dipyridamole; Drug Evaluation; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Female; Humans; Ketoconazole; Male; Methionine Sulfoximine; Mice; Neoplasms; Nitroimidazoles; Xanthines

1989
Sensitizers and protectors in radiotherapy.
    Cancer, 1985, May-01, Volume: 55, Issue:9 Suppl

    Topics: Amifostine; Animals; Aziridines; Clinical Trials as Topic; Drug Evaluation; Etanidazole; Glutathione; Humans; Misonidazole; Neoplasms; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation-Protective Agents; Radiation-Sensitizing Agents; Radiotherapy

1985
Hypoxic cell radiosensitizers: expectations and progress in drug development.
    International journal of radiation oncology, biology, physics, 1985, Volume: 11, Issue:2

    Topics: Clinical Trials as Topic; Combined Modality Therapy; Etanidazole; Humans; Metronidazole; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents

1985
Chemical sensitizers for hypoxic cells: a decade of experience in clinical radiotherapy.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1985, Volume: 3, Issue:2

    Topics: Adrenal Cortex Hormones; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Etanidazole; Humans; Metronidazole; Misonidazole; Neoplasms; Nimorazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents

1985

Trials

30 trial(s) available for azomycin and Neoplasms

ArticleYear
Initial results of hypoxia imaging using 1-alpha-D: -(5-deoxy-5-[18F]-fluoroarabinofuranosyl)-2-nitroimidazole ( 18F-FAZA).
    European journal of nuclear medicine and molecular imaging, 2009, Volume: 36, Issue:10

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Female; Fluorine Radioisotopes; Glioma; Head and Neck Neoplasms; Humans; Hypoxia; Lung Neoplasms; Lymphoma; Male; Middle Aged; Neoplasms; Nitroimidazoles; Positron-Emission Tomography; Radiopharmaceuticals; Young Adult

2009
A phase I study of the nitroimidazole hypoxia marker SR4554 using 19F magnetic resonance spectroscopy.
    British journal of cancer, 2009, Dec-01, Volume: 101, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Cell Hypoxia; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neoplasms; Nitroimidazoles; Oxygen; Partial Pressure; Young Adult

2009
PET imaging of hypoxia using [18F]HX4: a phase I trial.
    European journal of nuclear medicine and molecular imaging, 2010, Volume: 37, Issue:9

    Topics: Aged; Cell Hypoxia; Dose-Response Relationship, Drug; Female; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Neoplasms; Nitroimidazoles; Positron-Emission Tomography; Time Factors; Triazoles

2010
Phase 1 study of the safety, tolerability, and pharmacokinetics of TH-302, a hypoxia-activated prodrug, in patients with advanced solid malignancies.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2011, May-01, Volume: 17, Issue:9

    Topics: Adult; Aged; Antineoplastic Agents; Cell Hypoxia; Disease Progression; Dose-Response Relationship, Drug; Female; Humans; Male; Maximum Tolerated Dose; Middle Aged; Models, Biological; Neoplasms; Nitroimidazoles; Phosphoramide Mustards; Prodrugs

2011
A phase I study of SR-4554 via intravenous administration for noninvasive investigation of tumor hypoxia by magnetic resonance spectroscopy in patients with malignancy.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Nov-01, Volume: 9, Issue:14

    Topics: Adult; Aged; Biomarkers, Tumor; Chromatography, High Pressure Liquid; Female; Fluorine Radioisotopes; Half-Life; Humans; Hypoxia; Infusions, Intravenous; Magnetic Resonance Spectroscopy; Male; Maximum Tolerated Dose; Metabolic Clearance Rate; Middle Aged; Neoplasms; Nitroimidazoles

2003
Clinical trials with hypoxic cell sensitizers: time to retrench or time to push forward?
    International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:9

    Topics: Clinical Trials as Topic; Combined Modality Therapy; Dexamethasone; Drug Evaluation; Etanidazole; Humans; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents

1984
Dose-response relationships for human tumors: implications for clinical trials of dose modifying agents.
    International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:9

    Topics: Animals; Clinical Trials as Topic; Dose-Response Relationship, Radiation; Etanidazole; Humans; Mice; Misonidazole; Neoplasms; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents

1984
[Clinical trials of hypoxic cell sensitizer misonidazole].
    Gan no rinsho. Japan journal of cancer clinics, 1983, Volume: 29, Issue:6

    Topics: Brain Neoplasms; Clinical Trials as Topic; Drug Evaluation; Female; Glioma; Head and Neck Neoplasms; Humans; Lung Neoplasms; Male; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Random Allocation; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms

1983
Clinical trials with hypoxic cell sensitizers-the European experience.
    Progress in clinical and biological research, 1983, Volume: 132D

    Topics: Animals; Brain Neoplasms; Clinical Trials as Topic; Head and Neck Neoplasms; Humans; Methods; Misonidazole; Neoplasms; Nitroimidazoles; Urinary Bladder Neoplasms

1983
Misonidazole with dexamethasone rescue: an escalating dose toxicity study.
    International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:9

    Topics: Adolescent; Adult; Aged; Dexamethasone; Dose-Response Relationship, Drug; Humans; Middle Aged; Misonidazole; Neoplasms; Nervous System Diseases; Nitroimidazoles; Radiation-Sensitizing Agents

1984
A phase I study of the hypoxic cell radiosensitizer Ro-03-8799.
    International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:9

    Topics: Drug Evaluation; Humans; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents; Time Factors

1984
MRC randomized studied of misonidazole in combination with radiotherapy.
    The British journal of radiology, 1982, Volume: 55, Issue:654

    Topics: Clinical Trials as Topic; Humans; Misonidazole; Neoplasms; Nitroimidazoles

1982
Hypoxic cell sensitisers in radiotherapy.
    Lancet (London, England), 1976, Jan-24, Volume: 1, Issue:7952

    Topics: Animals; Clinical Trials as Topic; Drug Evaluation; Drug Evaluation, Preclinical; Humans; Hypoxia; In Vitro Techniques; Mice; Neoplasms; Neoplasms, Experimental; Nitroimidazoles; Oxygen Consumption; Radiation-Sensitizing Agents; Radiotherapy Dosage

1976
Initial United States clinical and pharmacologic evaluation of misonidazole (Ro-07-0582), an hypoxic cell radiosensitizer.
    International journal of radiation oncology, biology, physics, 1979, Volume: 5, Issue:6

    Topics: Administration, Oral; Drug Administration Schedule; Drug Evaluation; Humans; Misonidazole; Nausea; Neoplasms; Nitroimidazoles; Peripheral Nervous System Diseases; Sensation; Vomiting

1979
Misonidazole-a drug for trial in radiotherapy and oncology.
    International journal of radiation oncology, biology, physics, 1979, Volume: 5, Issue:6

    Topics: Anorexia; Clinical Trials as Topic; Drug Eruptions; Female; Humans; Male; Misonidazole; Nausea; Neoplasms; Nitroimidazoles; Peripheral Nervous System Diseases; Seizures

1979
[Clinical testing of the radiosensitizer RO-07-0582 (misonidazole). Dose tolerance, toxicity and pharmacokinetic studies, preliminary report (author's transl)].
    Bulletin du cancer, 1978, Volume: 65, Issue:4

    Topics: Bone Neoplasms; Clinical Trials as Topic; Glioma; Humans; Kinetics; Misonidazole; Neoplasms; Nitroimidazoles; Otorhinolaryngologic Diseases; Sarcoma

1978
Anaerobic wound infections in cancer patients: comparative trial of clindamycin, tinidazole, and doxycycline.
    Antimicrobial agents and chemotherapy, 1977, Volume: 12, Issue:5

    Topics: Anaerobiosis; Bacterial Infections; Clindamycin; Double-Blind Method; Doxycycline; Drug Resistance, Microbial; Humans; In Vitro Techniques; Microbial Sensitivity Tests; Neoplasms; Nitroimidazoles; Tinidazole

1977
Proceedings: The response of tumours to x rays and RO-07-0582.
    The British journal of radiology, 1976, Volume: 49, Issue:582

    Topics: Female; Humans; Methods; Neoplasms; Nitroimidazoles; Radiation Dosage; Radiation-Sensitizing Agents; Uterine Cervical Neoplasms

1976
Final report of the phase I trial of continuous infusion etanidazole (SR 2508): a Radiation Therapy Oncology Group study.
    International journal of radiation oncology, biology, physics, 1992, Volume: 22, Issue:3

    Topics: Brachytherapy; Combined Modality Therapy; Drug Evaluation; Etanidazole; Female; Humans; Infusions, Intravenous; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents; Time Factors

1992
The combination of multiple doses of etanidazole and pimonidazole in 48 patients: a toxicity and pharmacokinetic study.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1991, Volume: 20 Suppl 1

    Topics: Adult; Aged; Combined Modality Therapy; Dose-Response Relationship, Drug; Drug Combinations; Etanidazole; Female; Humans; Male; Middle Aged; Neoplasms; Nervous System Diseases; Nitroimidazoles; Radiation-Sensitizing Agents

1991
Abnormal clinical pharmacokinetics of the developmental radiosensitizers pimonidazole (Ro 03-8799) and etanidazole (SR 2508).
    International journal of radiation oncology, biology, physics, 1990, Volume: 18, Issue:5

    Topics: Aged; Clinical Trials as Topic; Etanidazole; Humans; Male; Middle Aged; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents

1990
Final report of the phase I trial of the hypoxic cell radiosensitizer SR 2508 (etanidazole) Radiation Therapy Oncology Group 83-03.
    International journal of radiation oncology, biology, physics, 1990, Volume: 18, Issue:2

    Topics: Adult; Canada; Combined Modality Therapy; Drug Evaluation; Etanidazole; Humans; Infusions, Intravenous; Multicenter Studies as Topic; Neoplasms; Nitroimidazoles; Peripheral Nervous System Diseases; Radiation-Sensitizing Agents; United States

1990
Initial results of a phase I trial of continuous infusion SR 2508 (etanidazole): a radiation therapy oncology group study.
    International journal of radiation oncology, biology, physics, 1989, Volume: 16, Issue:4

    Topics: Brachytherapy; Combined Modality Therapy; Drug Evaluation; Etanidazole; Humans; Infusions, Intravenous; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents

1989
A multiple dose study of the combined radiosensitizers Ro 03-8799 (pimonidazole) and SR 2508 (etanidazole).
    International journal of radiation oncology, biology, physics, 1989, Volume: 16, Issue:4

    Topics: Drug Combinations; Etanidazole; Humans; Neoplasms; Nitroimidazoles; Peripheral Nervous System Diseases; Radiation-Sensitizing Agents

1989
Non-chemotherapeutic agents that potentiate chemotherapy efficacy.
    Cancer treatment reviews, 1989, Volume: 16, Issue:1

    Topics: Adult; Amphotericin B; Animals; Antimetabolites; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Buthionine Sulfoximine; Calcium Channel Blockers; Calmodulin; Cardiotonic Agents; Child; Clinical Trials as Topic; Dipyridamole; Drug Evaluation; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Female; Humans; Ketoconazole; Male; Methionine Sulfoximine; Mice; Neoplasms; Nitroimidazoles; Xanthines

1989
Hypoxic cell radiosensitizers: illusion or elusion?
    International journal of radiation oncology, biology, physics, 1988, Volume: 15, Issue:3

    Topics: Clinical Trials as Topic; Drug Therapy, Combination; Etanidazole; Humans; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents

1988
Sensitizers and protectors in radiotherapy.
    Cancer, 1985, May-01, Volume: 55, Issue:9 Suppl

    Topics: Amifostine; Animals; Aziridines; Clinical Trials as Topic; Drug Evaluation; Etanidazole; Glutathione; Humans; Misonidazole; Neoplasms; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation-Protective Agents; Radiation-Sensitizing Agents; Radiotherapy

1985
Update: the potential for chemosensitization of alkylating agents by nitroimidazoles.
    Oncology (Williston Park, N.Y.), 1988, Volume: 2, Issue:12

    Topics: Alkylating Agents; Animals; Antineoplastic Agents; Cell Hypoxia; Clinical Trials as Topic; DNA Damage; Drug Synergism; Glutathione; Humans; Neoplasms; Nitroimidazoles; Tumor Cells, Cultured

1988
Hypoxic cell radiosensitizers: expectations and progress in drug development.
    International journal of radiation oncology, biology, physics, 1985, Volume: 11, Issue:2

    Topics: Clinical Trials as Topic; Combined Modality Therapy; Etanidazole; Humans; Metronidazole; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents

1985
Chemical sensitizers for hypoxic cells: a decade of experience in clinical radiotherapy.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1985, Volume: 3, Issue:2

    Topics: Adrenal Cortex Hormones; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Etanidazole; Humans; Metronidazole; Misonidazole; Neoplasms; Nimorazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents

1985

Other Studies

164 other study(ies) available for azomycin and Neoplasms

ArticleYear
Targeting tumor hypoxia: a third generation 2-nitroimidazole-indocyanine dye-conjugate with improved fluorescent yield.
    Organic & biomolecular chemistry, 2015, Dec-14, Volume: 13, Issue:46

    Topics: Animals; Cell Hypoxia; Cell Line, Tumor; Fluorescent Dyes; Hypoxia; Indocyanine Green; Mice, Inbred BALB C; Neoplasms; Nitroimidazoles; Optical Imaging

2015
β -[
    Current radiopharmaceuticals, 2017, Volume: 10, Issue:2

    Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Fluorine Radioisotopes; Male; Mice; Mice, Nude; Neoplasms; Nitroimidazoles; Positron-Emission Tomography; Radiochemistry; Radiopharmaceuticals; Tissue Distribution; Tumor Hypoxia

2017
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2022, 01-15, Volume: 28, Issue:2

    Topics: Cell Hypoxia; CTLA-4 Antigen; Humans; Hypoxia; Misonidazole; Neoplasms; Nitroimidazoles; Phosphoramide Mustards; Positron-Emission Tomography; Programmed Cell Death 1 Receptor; Tumor Microenvironment

2022
Immunofluorescence-Based Method to Assess Cancer Biomarker in the Hypoxic Region of the Tumor.
    Methods in molecular biology (Clifton, N.J.), 2022, Volume: 2413

    Topics: Biomarkers, Tumor; Cell Hypoxia; Fluorescent Antibody Technique; Humans; Hypoxia; Neoplasms; Nitroimidazoles; Tumor Microenvironment

2022
Assessment of hypoxia by pimonidazole staining following radiotherapy.
    Methods in cell biology, 2022, Volume: 172

    Topics: Biomarkers; Cell Hypoxia; Humans; Hypoxia; Neoplasms; Nitroimidazoles; Oxygen; Staining and Labeling; Tumor Microenvironment

2022
Coenzyme-depleting nanocarriers for enhanced redox cancer therapy under hypoxia.
    Journal of colloid and interface science, 2023, Volume: 641

    Topics: Animals; Antioxidants; Cell Line, Tumor; Coenzymes; Glutathione; Humans; Hypoxia; Mice; NADP; Neoplasms; Nitroimidazoles; Oxidation-Reduction; Sorafenib

2023
Design, Synthesis and Anticancer Evaluation of Nitroimidazole Radiosensitisers.
    Molecules (Basel, Switzerland), 2023, May-31, Volume: 28, Issue:11

    Topics: Cell Hypoxia; Humans; Hypoxia; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents

2023
Engineering
    Biochemistry, 2019, 09-03, Volume: 58, Issue:35

    Topics: Antineoplastic Agents; Biosensing Techniques; Cell Hypoxia; Drug Monitoring; Enzyme Activation; Escherichia coli; Escherichia coli Proteins; Etanidazole; Genetic Therapy; HCT116 Cells; Humans; Hydrocarbons, Fluorinated; Imidazoles; Molecular Imaging; Neoplasms; Nitroimidazoles; Nitroreductases; Positron-Emission Tomography; Prodrugs; Protein Engineering

2019
Design, synthesis, and biological study of 4-[(2-nitroimidazole-1
    Drug design, development and therapy, 2019, Volume: 13

    Topics: A549 Cells; Aniline Compounds; Antineoplastic Agents; Cell Hypoxia; ErbB Receptors; HT29 Cells; Humans; Inhibitory Concentration 50; Molecular Docking Simulation; Neoplasms; Nitroimidazoles; Protein Kinase Inhibitors; Quinazolines; Structure-Activity Relationship

2019
Application of Nitroimidazole-Carbobane-Modified Phenylalanine Derivatives as Dual-Target Boron Carriers in Boron Neutron Capture Therapy.
    Molecular pharmaceutics, 2020, 01-06, Volume: 17, Issue:1

    Topics: Animals; Boranes; Boron Compounds; Boron Neutron Capture Therapy; Cell Hypoxia; Cell Line, Tumor; Humans; Mice; Nanoparticles; Neoplasms; Nitroimidazoles; Phenylalanine; Tissue Distribution; Xenograft Model Antitumor Assays

2020
Hypoxia and pH co-triggered oxidative stress amplifier for tumor therapy.
    European journal of pharmacology, 2021, Aug-15, Volume: 905

    Topics: Acrolein; Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Survival; Glutathione; Humans; Hydrogen-Ion Concentration; Mice; NADP; Neoplasms; Nitroimidazoles; Oxidative Stress; Reactive Oxygen Species; Tumor Hypoxia; Tumor Microenvironment

2021
Evaluation of Vascularity, Blood Perfusion, and Oxygen Tension in Tumor Xenografts with Fluorescent Microscopy.
    Methods in molecular biology (Clifton, N.J.), 2018, Volume: 1741

    Topics: Animals; Disease Models, Animal; Fluorescent Antibody Technique; Heterografts; Humans; Hypoxia; Mice; Microscopy, Fluorescence; Neoplasm Staging; Neoplasms; Neovascularization, Pathologic; Nitroimidazoles; Oxygen

2018
Light-triggered theranostic liposomes for tumor diagnosis and combined photodynamic and hypoxia-activated prodrug therapy.
    Biomaterials, 2018, Volume: 185

    Topics: Animals; Antineoplastic Agents; Chlorophyllides; Delayed-Action Preparations; Humans; Light; Liposomes; MCF-7 Cells; Mice; Neoplasms; Nitroimidazoles; Optical Imaging; Photosensitizing Agents; Polyethylene Glycols; Porphyrins; Theranostic Nanomedicine; Tirapazamine; Tumor Hypoxia

2018
Nitroimidazole derivative incorporated liposomes for hypoxia-triggered drug delivery and enhanced therapeutic efficacy in patient-derived tumor xenografts.
    Acta biomaterialia, 2019, 01-01, Volume: 83

    Topics: Animals; Cell Hypoxia; Delayed-Action Preparations; Heterografts; Humans; Liposomes; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Transplantation; Neoplasms; Nitroimidazoles; Xenograft Model Antitumor Assays

2019
Fast and sensitive dynamic oxygen-enhanced MRI with a cycling gas challenge and independent component analysis.
    Magnetic resonance in medicine, 2019, Volume: 81, Issue:4

    Topics: Animals; Biomarkers; Biomarkers, Tumor; Cell Hypoxia; Cell Line, Tumor; Female; HCT116 Cells; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Mice; Neoplasm Transplantation; Neoplasms; Nitroimidazoles; Oxygen; Platelet Endothelial Cell Adhesion Molecule-1; Tumor Microenvironment

2019
In Vivo Ester Hydrolysis as a New Approach in Development of Positron Emission Tomography Tracers for Imaging Hypoxia.
    Molecular pharmaceutics, 2019, 03-04, Volume: 16, Issue:3

    Topics: Animals; Cell Hypoxia; Cell Line, Tumor; Disease Models, Animal; Esters; Female; Fluorine Radioisotopes; Hydrolysis; Hypoxia; Male; Mice; Mice, Inbred BALB C; Neoplasms; Nitroimidazoles; Positron-Emission Tomography; Radioactive Tracers; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Tissue Distribution

2019
Functional CRISPR and shRNA Screens Identify Involvement of Mitochondrial Electron Transport in the Activation of Evofosfamide.
    Molecular pharmacology, 2019, Volume: 95, Issue:6

    Topics: Cell Line, Tumor; Cell Proliferation; Cell Survival; CRISPR-Cas Systems; Electron Transport; Gene Expression Regulation; Gene Regulatory Networks; HCT116 Cells; Humans; Mitochondria; Neoplasms; Nitroimidazoles; Phosphoramide Mustards; Prodrugs; RNA, Small Interfering; Sequence Analysis, RNA

2019
ERO1α is a novel endogenous marker of hypoxia in human cancer cell lines.
    BMC cancer, 2019, May-29, Volume: 19, Issue:1

    Topics: Animals; Antigens, Neoplasm; Biomarkers, Tumor; Carbonic Anhydrase IX; Cell Hypoxia; Cell Line, Tumor; HCT116 Cells; HeLa Cells; HT29 Cells; Humans; Membrane Glycoproteins; Mice; Neoplasm Transplantation; Neoplasms; Nitroimidazoles; Oxidoreductases

2019
Targeting tumor hypoxia with 2-nitroimidazole-indocyanine green dye conjugates.
    Journal of biomedical optics, 2013, Volume: 18, Issue:6

    Topics: Animals; Cell Line, Tumor; Coloring Agents; Equipment Design; Ethanolamine; Female; Hypoxia; Immunohistochemistry; Indocyanine Green; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Neoplasms; Nitroimidazoles; Spectrometry, Fluorescence; Time Factors

2013
Phosphorescent ruthenium complexes with a nitroimidazole unit that image oxygen fluctuation in tumor tissue.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2015, Feb-02, Volume: 21, Issue:6

    Topics: Animals; Cell Hypoxia; Cell Line, Tumor; Coordination Complexes; Energy Transfer; Female; Green Fluorescent Proteins; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Fluorescence; Neoplasms; Nitroimidazoles; Optical Imaging; Oxygen; Ruthenium; Transplantation, Heterologous

2015
The biological effect of the nitroimidazole derivative of a polypyridyl ruthenium complex on cancer and endothelial cells.
    Metallomics : integrated biometal science, 2015, Volume: 7, Issue:3

    Topics: Animals; Apoptosis; Cell Adhesion; Cell Cycle Checkpoints; Cell Death; Cell Line, Tumor; Cisplatin; Coordination Complexes; Endocytosis; Endothelial Cells; Gene Expression Regulation; Humans; Inhibitory Concentration 50; Mice; Microscopy, Fluorescence; Neoplasms; Neovascularization, Physiologic; Nitroimidazoles; Oxidative Stress; Pyridines; RNA, Messenger; Ruthenium; Subcellular Fractions; Wound Healing

2015
A Comparative pO2 Probe and [18F]-Fluoro-Azomycinarabino-Furanoside ([18F]FAZA) PET Study Reveals Anesthesia-Induced Impairment of Oxygenation and Perfusion in Tumor and Muscle.
    PloS one, 2015, Volume: 10, Issue:4

    Topics: Anesthesia; Animals; Blood Pressure; Cell Line, Tumor; Female; Isoflurane; Ketamine; Mice, Inbred BALB C; Molecular Probes; Muscles; Neoplasms; Nitroimidazoles; Oxygen; Partial Pressure; Perfusion; Positron-Emission Tomography; Respiration; Systole; Xylazine

2015
A limited overlap between intratumoral distribution of 1-(5-fluoro-5-deoxy-α-D-arabinofuranosyl)-2-nitroimidazole and copper-diacetyl-bis[N(4)-methylthiosemicarbazone].
    Oncology reports, 2015, Volume: 34, Issue:3

    Topics: Animals; Biomarkers, Tumor; Cell Hypoxia; Cell Line, Tumor; Cell Tracking; Coordination Complexes; Fluorodeoxyglucose F18; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Mice; Neoplasms; Nitroimidazoles; Organometallic Compounds; Positron-Emission Tomography; Radiography; Thiosemicarbazones; Xenograft Model Antitumor Assays

2015
Design, synthesis and biological evaluation of pyrazolyl-nitroimidazole derivatives as potential EGFR/HER-2 kinase inhibitors.
    Bioorganic & medicinal chemistry letters, 2016, Jan-15, Volume: 26, Issue:2

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Design; ErbB Receptors; Humans; Molecular Docking Simulation; Neoplasms; Nitroimidazoles; Protein Kinase Inhibitors; Pyrazoles; Receptor, ErbB-2

2016
Multiparametric Analysis of the Relationship Between Tumor Hypoxia and Perfusion with ¹⁸F-Fluoroazomycin Arabinoside and ¹⁵O-H₂O PET.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2016, Volume: 57, Issue:4

    Topics: Aged; Carcinoma, Non-Small-Cell Lung; Cluster Analysis; Female; Humans; Hypoxia; Lung Neoplasms; Male; Middle Aged; Neoplasms; Nitroimidazoles; Oxygen Radioisotopes; Positron-Emission Tomography; Radiopharmaceuticals; Regional Blood Flow; Water

2016
RRx-001, an epigenetic-based radio- and chemosensitizer, has vascular normalizing effects on SCCVII and U87 tumors.
    Clinical epigenetics, 2016, Volume: 8

    Topics: Actins; Animals; Antineoplastic Agents; Azetidines; Cell Hypoxia; Cell Line, Tumor; Epigenesis, Genetic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Neoplasm Transplantation; Neoplasms; Nitro Compounds; Nitroimidazoles; Tumor Microenvironment

2016
Targeting and Treatment of Tumor Hypoxia by Newly Designed Prodrug Possessing High Permeability in Solid Tumors.
    Molecular pharmaceutics, 2016, 07-05, Volume: 13, Issue:7

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Humans; Male; Mice; Mice, Inbred BALB C; Neoplasms; Nitroimidazoles; Permeability; Prodrugs; Tumor Hypoxia

2016
Synthesis and Biological Evaluation of Iodoglucoazomycin (I-GAZ), an Azomycin-Glucose Adduct with Putative Applications in Diagnostic Imaging and Radiotherapy of Hypoxic Tumors.
    ChemMedChem, 2016, 08-05, Volume: 11, Issue:15

    Topics: Animals; Cell Line, Tumor; Glucose; Glucose Transporter Type 1; Glucosides; Heterografts; Humans; Iodine Radioisotopes; Mice, Inbred BALB C; Neoplasm Transplantation; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents; Radiopharmaceuticals; Tissue Distribution; Tumor Burden; Tumor Hypoxia

2016
Cellular uptake of PET tracers of glucose metabolism and hypoxia and their linkage.
    European journal of nuclear medicine and molecular imaging, 2008, Volume: 35, Issue:12

    Topics: Animals; Binding, Competitive; Biological Transport; Cell Count; Cell Line, Tumor; Female; Fluorodeoxyglucose F18; Glucose; Humans; Hypoxia; Mice; Neoplasms; Nitroimidazoles; Oxygen; Positron-Emission Tomography; Time Factors

2008
On the isolation and evaluation of a novel unsubstituted 5-nitroimidazole derivative as an agent to target tumor hypoxia.
    Bioorganic & medicinal chemistry letters, 2008, Oct-01, Volume: 18, Issue:19

    Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Hypoxia; Mice; Molecular Structure; Neoplasms; Nitroimidazoles; Organotechnetium Compounds

2008
Noninvasive molecular imaging of hypoxia in human xenografts: comparing hypoxia-induced gene expression with endogenous and exogenous hypoxia markers.
    Cancer research, 2008, Oct-15, Volume: 68, Issue:20

    Topics: Animals; Antigens, Neoplasm; Arabinofuranosyluracil; Autoradiography; Biomarkers; Carbonic Anhydrase IX; Carbonic Anhydrases; Cell Hypoxia; Etanidazole; Female; Gene Expression; Green Fluorescent Proteins; Herpesvirus 1, Human; HT29 Cells; Humans; Hydrocarbons, Fluorinated; Immunohistochemistry; Mice; Mice, Nude; Misonidazole; Neoplasm Transplantation; Neoplasms; Nitroimidazoles; Positron-Emission Tomography; Thymidine Kinase; Tissue Distribution; Transplantation, Heterologous

2008
Pharmacologically increased tumor hypoxia can be measured by 18F-Fluoroazomycin arabinoside positron emission tomography and enhances tumor response to hypoxic cytotoxin PR-104.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2009, Dec-01, Volume: 15, Issue:23

    Topics: Animals; Cell Hypoxia; Cell Line, Tumor; Dose-Response Relationship, Drug; Fluorine Radioisotopes; Humans; Mice; Mice, Nude; Mitochondria; Neoplasm Transplantation; Neoplasms; Nitrogen Mustard Compounds; Nitroimidazoles; Oxygen Consumption; Positron-Emission Tomography; Radiopharmaceuticals

2009
Detection of hypoxia in microscopic tumors using 131I-labeled iodo-azomycin galactopyranoside (131I-IAZGP) digital autoradiography.
    European journal of nuclear medicine and molecular imaging, 2010, Volume: 37, Issue:2

    Topics: Animals; Antigens, Neoplasm; Autoradiography; Biological Transport; Carbonic Anhydrase IX; Carbonic Anhydrases; Cell Hypoxia; Cell Line, Tumor; Female; Galactosides; Humans; Immunohistochemistry; Mice; Neoplasms; Nitroimidazoles; Radioactive Tracers; Radiographic Image Enhancement

2010
Immunohistochemical detection of tumour hypoxia.
    Methods in molecular biology (Clifton, N.J.), 2010, Volume: 611

    Topics: Animals; Glucose Transporter Type 1; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Mice; Neoplasms; Nitroimidazoles

2010
Is (18)F-FDG a surrogate tracer to measure tumor hypoxia? Comparison with the hypoxic tracer (14)C-EF3 in animal tumor models.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2010, Volume: 97, Issue:2

    Topics: Animals; Carbon Radioisotopes; Disease Models, Animal; Fiducial Markers; Fluorodeoxyglucose F18; Hypoxia; Male; Mice; Neoplasms; Nitroimidazoles; Radionuclide Imaging

2010
Hypoxia and perfusion labeling during photodynamic therapy.
    Methods in molecular biology (Clifton, N.J.), 2010, Volume: 635

    Topics: Animals; Biomarkers; Blood Circulation; Blood Vessels; Cell Hypoxia; Dihematoporphyrin Ether; Immunohistochemistry; Mice; Neoplasms; Nitroimidazoles; Photochemotherapy; Platelet Endothelial Cell Adhesion Molecule-1; Tissue Fixation

2010
Effect of cetuximab and fractionated irradiation on tumour micro-environment.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2010, Volume: 97, Issue:2

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Carcinoma, Squamous Cell; Cell Line, Tumor; Cetuximab; Combined Modality Therapy; Dose Fractionation, Radiation; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Male; Mice; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents; Signal Transduction; Transplantation, Heterologous; Xenograft Model Antitumor Assays

2010
Assessing hypoxia in animal tumor models based on pharmocokinetic analysis of dynamic FAZA PET.
    Acta oncologica (Stockholm, Sweden), 2010, Volume: 49, Issue:7

    Topics: Animals; Carcinoma, Squamous Cell; Female; Gingival Neoplasms; Humans; Hypoxia; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Neoplasms; Nitroimidazoles; Positron-Emission Tomography; Transplantation, Heterologous; Tumor Cells, Cultured; Uterine Cervical Neoplasms

2010
Synthesis and biological characterisation of novel dithiocarbamate containing 5-nitroimidazole (99m)Tc-complexes as potential agents for targeting hypoxia.
    Bioorganic & medicinal chemistry letters, 2011, Jan-01, Volume: 21, Issue:1

    Topics: Animals; Carbamates; Cell Hypoxia; Metronidazole; Mice; Neoplasms; Nitroimidazoles; Organotechnetium Compounds; Radionuclide Imaging; Radiopharmaceuticals

2011
Synthesis of hypoxia imaging agent 1-(5-deoxy-5-fluoro-α-D-arabinofuranosyl)-2-nitroimidazole using microfluidic technology.
    Nuclear medicine and biology, 2011, Volume: 38, Issue:2

    Topics: Animals; Cell Hypoxia; Cell Line, Tumor; Female; Mice; Mice, Inbred BALB C; Microfluidic Analytical Techniques; Neoplasms; Nitroimidazoles; Positron-Emission Tomography; Radiochemistry; Ribose

2011
High-yield automated synthesis of [18F]fluoroazomycin arabinoside ([18F]FAZA) for hypoxia-specific tumor imaging.
    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2011, Volume: 69, Issue:7

    Topics: Automation; Cell Hypoxia; Fluorine Radioisotopes; Humans; Neoplasms; Nitroimidazoles

2011
Quantitative assessment of hypoxia subtypes in microcirculatory supply units of malignant tumors using (immuno-)fluorescence techniques.
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2011, Volume: 187, Issue:4

    Topics: Benzimidazoles; Cell Hypoxia; Cell Line, Tumor; Diffusion; Humans; Microcirculation; Microscopy, Fluorescence; Microvessels; Neoplasms; Nitroimidazoles; Perfusion Imaging; Prognosis; Radiation-Sensitizing Agents; Tumor Cells, Cultured

2011
Imaging tumor hypoxia by near-infrared fluorescence tomography.
    Journal of biomedical optics, 2011, Volume: 16, Issue:6

    Topics: Animals; Cell Hypoxia; Female; Immunohistochemistry; Indocyanine Green; Mice; Mice, Inbred BALB C; Molecular Imaging; Neoplasm Transplantation; Neoplasms; Nitroimidazoles; Spectrometry, Fluorescence; Spectroscopy, Near-Infrared; Tomography

2011
Preparation of nucleosides derived from 2-nitroimidazole and D-arabinose, D-ribose, and D-galactose by the Vorbrüggen method and their conversion to potential precursors for tracers to image hypoxia.
    The Journal of organic chemistry, 2011, Oct-21, Volume: 76, Issue:20

    Topics: Acetonitriles; Animals; Arabinose; Galactose; Humans; Hypoxia; Isomerism; Magnetic Resonance Spectroscopy; Molecular Imaging; Neoplasms; Nitroimidazoles; Nucleosides; Radioactive Tracers; Ribose; Silanes

2011
Molecular and cellular pharmacology of the hypoxia-activated prodrug TH-302.
    Molecular cancer therapeutics, 2012, Volume: 11, Issue:3

    Topics: Animals; Cell Hypoxia; Cell Line, Tumor; Cell Survival; CHO Cells; Comet Assay; Cricetinae; Cricetulus; DNA Damage; Dose-Response Relationship, Drug; HCT116 Cells; Histones; HT29 Cells; Humans; Inhibitory Concentration 50; Molecular Structure; Neoplasms; Nitroimidazoles; Oxidation-Reduction; Oxygen; Phosphoramide Mustards; Phosphorylation; Prodrugs; Spheroids, Cellular; Tumor Stem Cell Assay

2012
2-Nitroimidazole-tricarbocyanine conjugate as a near-infrared fluorescent probe for in vivo imaging of tumor hypoxia.
    Bioconjugate chemistry, 2012, Mar-21, Volume: 23, Issue:3

    Topics: Animals; Carbocyanines; Cell Hypoxia; Fluorescent Dyes; Mice; Mice, Nude; Neoplasms; Nitroimidazoles; Spectroscopy, Near-Infrared

2012
Development of a hypoxia-selective near-infrared fluorescent probe for non-invasive tumor imaging.
    Chemical & pharmaceutical bulletin, 2012, Volume: 60, Issue:3

    Topics: Animals; Carbocyanines; Cell Hypoxia; Cell Line, Tumor; Fluorescence; Fluorescent Dyes; Humans; Hydrophobic and Hydrophilic Interactions; Mice; Neoplasms; Nitroimidazoles; Solubility; Spectroscopy, Near-Infrared

2012
Targeting hypoxia brings breath of fresh air to cancer therapy.
    Nature medicine, 2012, May-04, Volume: 18, Issue:5

    Topics: Cell Hypoxia; Clinical Trials as Topic; Humans; Neoplasms; Nitroimidazoles; Phosphoramide Mustards

2012
Influence of ligand denticity on the properties of novel ⁹⁹mTc(I)-carbonyl complexes. Application to the development of radiopharmaceuticals for imaging hypoxic tissue.
    Bioorganic & medicinal chemistry, 2012, Jul-01, Volume: 20, Issue:13

    Topics: Animals; Cell Line, Tumor; Click Chemistry; Contrast Media; Coordination Complexes; Diagnostic Imaging; Humans; Ketones; Ligands; Metronidazole; Mice; Mice, Inbred C57BL; Neoplasms; Nitroimidazoles; Protein Binding; Proteins; Radionuclide Imaging; Radiopharmaceuticals; Rhenium; Technetium; Tissue Distribution

2012
Design, synthesis, and preliminary biological evaluation of 6-O-glucose-azomycin adducts for diagnosis and therapy of hypoxic tumors.
    Journal of medicinal chemistry, 2012, Jul-12, Volume: 55, Issue:13

    Topics: Cell Hypoxia; Cell Line, Tumor; Drug Design; Glucose Transport Proteins, Facilitative; Glucosides; Glycosides; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents; Radionuclide Imaging; Radiopharmaceuticals; Transcriptional Activation

2012
Development of (99m)Tc-N4-NIM for molecular imaging of tumor hypoxia.
    Journal of biomedicine & biotechnology, 2012, Volume: 2012

    Topics: Animals; Cell Hypoxia; Female; Heterocyclic Compounds, 1-Ring; Humans; Male; Molecular Imaging; Neoplasms; Nitroimidazoles; Organotechnetium Compounds; Oxygen; Rabbits; Radioactive Tracers; Radionuclide Imaging; Radiopharmaceuticals; Rats; Rats, Inbred F344; Tissue Distribution; Tumor Microenvironment

2012
Nitroreductase, a near-infrared reporter platform for in vivo time-domain optical imaging of metastatic cancer.
    Cancer research, 2013, Feb-15, Volume: 73, Issue:4

    Topics: Animals; Anti-Infective Agents; Carbocyanines; Cell Line, Tumor; Cell Survival; Escherichia coli Proteins; Green Fluorescent Proteins; HEK293 Cells; Humans; Luciferases; Magnetic Resonance Imaging; Metronidazole; Mice; Mice, Inbred NOD; Mice, SCID; Microscopy, Fluorescence; Neoplasm Metastasis; Neoplasms; Nitroimidazoles; Nitroreductases; Reproducibility of Results; Transfection; Xenograft Model Antitumor Assays

2013
Dynamics of tumor hypoxia in response to patupilone and ionizing radiation.
    PloS one, 2012, Volume: 7, Issue:12

    Topics: Animals; Biomarkers, Tumor; Cell Death; Cell Hypoxia; Cell Line, Tumor; Cobalt; Combined Modality Therapy; Epothilones; Genes, Reporter; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Luciferases; Mice; Mice, Nude; Neoplasms; Nitroimidazoles; Oxygen; Partial Pressure; Protein Structure, Tertiary; Radiation, Ionizing; Xenograft Model Antitumor Assays

2012
18F-Fluoroerythronitroimidazole radiation dosimetry in cancer studies.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2002, Volume: 43, Issue:12

    Topics: Female; Fluorine Radioisotopes; Humans; Male; Misonidazole; Neoplasms; Nitroimidazoles; Radiation Dosage; Radiopharmaceuticals; Tomography, Emission-Computed

2002
Is HIF-1alpha a good marker for tumor hypoxia?
    International journal of radiation oncology, biology, physics, 2003, Jul-15, Volume: 56, Issue:4

    Topics: Animals; Biomarkers, Tumor; Cell Hypoxia; Flow Cytometry; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents; Transcription Factors

2003
TNP-470 promotes initial vascular sprouting in xenograft tumors.
    Molecular cancer therapeutics, 2004, Volume: 3, Issue:3

    Topics: Angiogenesis Inhibitors; Angiography; Animals; Antibiotics, Antineoplastic; Apoptosis; Capillaries; Cell Line, Tumor; Cyclohexanes; Fluorescein; Humans; Hypoxia; Immunohistochemistry; In Situ Hybridization; In Situ Nick-End Labeling; Lectins; Mice; Mice, Nude; Microcirculation; Neoplasm Transplantation; Neoplasms; Neovascularization, Pathologic; Nitroimidazoles; O-(Chloroacetylcarbamoyl)fumagillol; Radiation-Sensitizing Agents; Sesquiterpenes; Vascular Endothelial Growth Factor A; Wilms Tumor

2004
Improved immunohistochemical method for detecting hypoxia gradients in mouse tissues and tumors.
    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2004, Volume: 52, Issue:6

    Topics: Animals; Antibodies, Monoclonal; Cell Hypoxia; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Immunohistochemistry; Mice; Neoplasms; Nitroimidazoles; Organ Specificity

2004
Hypoxia-specific tumor imaging with 18F-fluoroazomycin arabinoside.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2005, Volume: 46, Issue:1

    Topics: Animals; Cell Hypoxia; Disease Models, Animal; Female; Metabolic Clearance Rate; Mice; Mice, Inbred BALB C; Mice, Nude; Misonidazole; Neoplasms; Nitroimidazoles; Organ Specificity; Oxidation-Reduction; Oxygen; Radionuclide Imaging; Radiopharmaceuticals; Tissue Distribution

2005
Assessment of regional tumor hypoxia using 18F-fluoromisonidazole and 64Cu(II)-diacetyl-bis(N4-methylthiosemicarbazone) positron emission tomography: Comparative study featuring microPET imaging, Po2 probe measurement, autoradiography, and fluorescent mic
    International journal of radiation oncology, biology, physics, 2005, Apr-01, Volume: 61, Issue:5

    Topics: Animals; Autoradiography; Benzimidazoles; Cell Hypoxia; Coordination Complexes; Fluorodeoxyglucose F18; Humans; Immunohistochemistry; Male; Microscopy, Fluorescence; Misonidazole; Neoplasms; Nitroimidazoles; Organometallic Compounds; Positron-Emission Tomography; Radiation-Sensitizing Agents; Radiopharmaceuticals; Rats; Rats, Nude; Thiosemicarbazones; Transplantation, Heterologous

2005
Dependence of FDG uptake on tumor microenvironment.
    International journal of radiation oncology, biology, physics, 2005, Jun-01, Volume: 62, Issue:2

    Topics: Animals; Autoradiography; Benzimidazoles; Bromodeoxyuridine; Cell Hypoxia; Cell Proliferation; Coloring Agents; Fluorodeoxyglucose F18; Glucose; Male; Mice; Mice, Nude; Neoplasms; Nitroimidazoles; Prostatic Neoplasms; Radiopharmaceuticals

2005
A one-pot synthesis of 1-alpha- and 1-beta-D-arabinofuranosyl-2-nitroimidazoles: synthons to the markers of tumor hypoxia.
    Nucleosides, nucleotides & nucleic acids, 2005, Volume: 24, Issue:3

    Topics: Biomarkers, Tumor; Cell Hypoxia; Molecular Structure; Monosaccharides; Neoplasms; Nitroimidazoles

2005
Hypoxic cell turnover in different solid tumor lines.
    International journal of radiation oncology, biology, physics, 2005, Jul-15, Volume: 62, Issue:4

    Topics: Animals; Benzimidazoles; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Coloring Agents; Half-Life; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms; Nitroimidazoles; Time Factors

2005
Reduced expression of hypoxia-inducible factor-1alpha in perinecrotic regions of solid tumors.
    Cancer research, 2005, Aug-15, Volume: 65, Issue:16

    Topics: Animals; Antigens, Neoplasm; Astrocytoma; Biomarkers, Tumor; Biopsy; Carbonic Anhydrase IX; Carbonic Anhydrases; Cell Hypoxia; Cell Line, Tumor; Colonic Neoplasms; Female; Flow Cytometry; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Image Processing, Computer-Assisted; Mice; Mice, SCID; Necrosis; Neoplasms; Nitroimidazoles; Transcription Factors; Transplantation, Heterologous; Uterine Cervical Neoplasms

2005
A comparison of oral and intravenous pimonidazole in canine tumors using intravenous CCI-103F as a control hypoxia marker.
    International journal of radiation oncology, biology, physics, 2006, Feb-01, Volume: 64, Issue:2

    Topics: Administration, Oral; Animals; Area Under Curve; Cell Hypoxia; Cell Line; Cricetinae; Cricetulus; Dog Diseases; Dogs; Feasibility Studies; Hydrogen-Ion Concentration; Injections, Intravenous; Neoplasms; Nitroimidazoles

2006
[Hypoxia: a therapeutic target].
    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2005, Volume: 7, Issue:11

    Topics: Antineoplastic Agents; Apoptosis; Cell Hypoxia; Cyclic N-Oxides; Drug Resistance, Neoplasm; Glycolysis; Humans; Hypoxia-Inducible Factor 1; Neoplasm Proteins; Neoplasms; Nitroimidazoles; Oxidation-Reduction; Oxygen; Quinones; Radiation Tolerance; Radiation-Sensitizing Agents; Reducing Agents

2005
Imaging hypoxia after oxygenation-modification: comparing [18F]FMISO autoradiography with pimonidazole immunohistochemistry in human xenograft tumors.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2006, Volume: 80, Issue:2

    Topics: Animals; Autoradiography; Carcinoma, Squamous Cell; Cell Hypoxia; Fluorine Radioisotopes; Glioblastoma; Head and Neck Neoplasms; Humans; Immunohistochemistry; Mice; Mice, Inbred BALB C; Mice, Nude; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Radionuclide Imaging

2006
Evaluation of 99mTc(CO)3 complex of 2-methyl-5-nitroimidazole as an agent for targeting tumor hypoxia.
    Bioorganic & medicinal chemistry, 2006, Dec-01, Volume: 14, Issue:23

    Topics: Animals; Drug Carriers; Drug Stability; Fibrosarcoma; Hypoxia; Ligands; Mice; Neoplasms; Nitroimidazoles; Organotechnetium Compounds; Tissue Distribution

2006
Detecting changes in tumor hypoxia with carbonic anhydrase IX and pimonidazole.
    Cancer biology & therapy, 2007, Volume: 6, Issue:1

    Topics: Animals; Antigens, Neoplasm; Biomarkers; Carbonic Anhydrase IX; Carbonic Anhydrases; Cell Hypoxia; Cell Line, Tumor; Humans; Immunohistochemistry; Mice; Neoplasms; Nitroimidazoles; Oxygen Consumption

2007
DNA damage and nitric oxide synthesis in experimentally infected Balb/c mice with Trypanosoma cruzi.
    Experimental parasitology, 2007, Volume: 116, Issue:3

    Topics: Animals; Blood Cells; Chagas Disease; DNA Damage; Liver; Male; Mice; Mice, Inbred BALB C; Myocardium; Neoplasms; Nitric Oxide; Nitroimidazoles; Random Allocation; Spleen; Trypanocidal Agents; Trypanosoma cruzi

2007
Determination of tumour hypoxia with the PET tracer [18F]EF3: improvement of the tumour-to-background ratio in a mouse tumour model.
    European journal of nuclear medicine and molecular imaging, 2007, Volume: 34, Issue:9

    Topics: Animals; Area Under Curve; Hypoxia; Liver; Male; Mice; Mice, Inbred C3H; Neoplasms; Nitroimidazoles; Ornidazole; Positron-Emission Tomography; Radiopharmaceuticals; Spironolactone; Time Factors; Tissue Distribution; Treatment Outcome

2007
Conformational exchange in pimonidazole--a hypoxia marker.
    Magnetic resonance in chemistry : MRC, 2007, Volume: 45, Issue:8

    Topics: Animals; Biomarkers; Cell Hypoxia; Humans; Magnetic Resonance Spectroscopy; Molecular Conformation; Neoplasms; Nitroimidazoles

2007
Imaging of tumor hypoxia with [124I]IAZA in comparison with [18F]FMISO and [18F]FAZA--first small animal PET results.
    Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 2007, Volume: 10, Issue:2

    Topics: Animals; Cell Hypoxia; Cell Line, Tumor; Female; Fluorine Radioisotopes; Humans; Iodine Radioisotopes; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Neoplasms; Nitroimidazoles; Positron-Emission Tomography; Radiopharmaceuticals; Tissue Distribution

2007
Correlative imaging of hypoxia and angiogenesis in oncology.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2008, Volume: 49, Issue:4

    Topics: Autoradiography; Cell Hypoxia; Glucosides; Humans; Neoplasms; Neovascularization, Pathologic; Nitroimidazoles; Oligopeptides; Positron-Emission Tomography

2008
Clinical perspectives for the use of new hypoxic cell sensitizers.
    International journal of radiation oncology, biology, physics, 1982, Volume: 8, Issue:9

    Topics: Animals; Cyclophosphamide; Dogs; Drug Therapy, Combination; Etanidazole; Humans; Melphalan; Mice; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Solubility

1982
Radiosensitizers: a conference preview.
    International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:8

    Topics: Animals; Aziridines; Buthionine Sulfoximine; Carmustine; Combined Modality Therapy; Drug Synergism; Etanidazole; Humans; Ketones; Lomustine; Maleates; Methionine Sulfoximine; Mice; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents

1984
Initial report of the phase I trial of the hypoxic cell radiosensitizer SR-2508.
    International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:9

    Topics: Drug Evaluation; Etanidazole; Humans; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents; Time Factors

1984
The pharmacokinetics and tumor and neural tissue penetrating properties of SR-2508 and SR-2555 in the dog--hydrophilic radiosensitizers potentially less toxic than misonidazole.
    Radiation research, 1980, Volume: 84, Issue:3

    Topics: Administration, Oral; Animals; Biological Availability; Dog Diseases; Dogs; Drug Evaluation, Preclinical; Etanidazole; Female; Injections, Intravenous; Kinetics; Male; Misonidazole; Neoplasms; Nervous System; Nitroimidazoles; Radiation-Sensitizing Agents; Structure-Activity Relationship

1980
Hypoxia-mediated radiation and chemo-sensitizing drugs.
    British journal of cancer, 1984, Volume: 50, Issue:3

    Topics: Animals; Drug Synergism; Humans; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents

1984
Chemical modifiers of cancer treatment. Part 1. Banff, Canada, 27 November-1 December, 1983.
    International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:8

    Topics: Animals; Combined Modality Therapy; Humans; In Vitro Techniques; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents

1984
A phase I study of the combination of benznidazole and CCNU in man.
    International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:9

    Topics: Drug Evaluation; Drug Synergism; Drug Therapy, Combination; Humans; Lomustine; Neoplasms; Nitroimidazoles; Trypanocidal Agents

1984
The clinical testing of Ro 03-8799--pharmacokinetics, toxicology, tissue and tumor concentrations.
    International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:9

    Topics: Drug Evaluation; Female; Humans; Male; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents; Time Factors; Tissue Distribution

1984
A phase I clinical study of Nimorazole as a hypoxic radiosensitizer.
    International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:9

    Topics: Adult; Aged; Dose-Response Relationship, Drug; Drug Evaluation; Female; Humans; Male; Middle Aged; Neoplasms; Nimorazole; Nitroimidazoles; Radiation-Sensitizing Agents; Time Factors

1984
The effect of a hypoxic cell sensitizer on cancer radiotherapy: an analysis by a model.
    Strahlentherapie, 1984, Volume: 160, Issue:10

    Topics: Humans; Hypoxia; Mathematics; Misonidazole; Models, Theoretical; Neoplasms; Nitroimidazoles

1984
Radiosensitizing drugs in relation to individualized treatment.
    Strahlentherapie, 1984, Volume: 160, Issue:11

    Topics: Alkylating Agents; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Humans; Hypoxia; In Vitro Techniques; Misonidazole; Neoplasms; Nervous System; Nitroimidazoles; Radiation Tolerance; Radiation-Sensitizing Agents; Sulfhydryl Reagents

1984
Combined treatment of radiation and local injections of misonidazole.
    International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:12

    Topics: Combined Modality Therapy; Humans; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents

1984
The pharmacokinetics of a new radiosensitiser, Ro 03-8799 in humans.
    European journal of clinical pharmacology, 1984, Volume: 27, Issue:4

    Topics: Adult; Aged; Blood Proteins; Erythrocytes; Feces; Female; Humans; Injections, Intravenous; Kinetics; Male; Middle Aged; Neoplasms; Nitroimidazoles; Oxides; Protein Binding; Radiation-Sensitizing Agents; Time Factors

1984
Electron-affinic compounds for labelling hypoxic cells: the synthesis and characterization of 1-[2-(2-iodophenoxy)-ethyl]-2-nitroimidazole.
    Nuklearmedizin. Nuclear medicine, 1984, Volume: 23, Issue:2

    Topics: Animals; Male; Mice; Neoplasms; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radionuclide Imaging; Tissue Distribution

1984
Radiosensitization of a mouse tumour by Ro 03-8799: acute and protracted administration.
    International journal of radiation biology and related studies in physics, chemistry, and medicine, 1983, Volume: 44, Issue:2

    Topics: Animals; Injections, Intraperitoneal; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Mice; Neoplasm Transplantation; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents

1983
[Clinical studies of combined therapy of radiation and local injection of misonidazole].
    Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica, 1983, May-25, Volume: 43, Issue:5

    Topics: Adult; Aged; Female; Humans; Injections; Male; Middle Aged; Misonidazole; Neoplasms; Nitroimidazoles; Radiotherapy Dosage

1983
[Clinical study on radiotherapy in combination with misonidazole].
    Nihon Gan Chiryo Gakkai shi, 1983, Aug-20, Volume: 18, Issue:5

    Topics: Aged; Esophageal Neoplasms; Female; Humans; Lung Neoplasms; Middle Aged; Misonidazole; Neoplasms; Nitroimidazoles; Pharyngeal Neoplasms; Radiation-Sensitizing Agents

1983
High-performance liquid chromatographic analysis of the new hypoxic cell radiosensitiser, Ro 03-8799, in biological samples.
    Journal of chromatography, 1983, Apr-08, Volume: 273, Issue:2

    Topics: Animals; Bile; Chromatography, High Pressure Liquid; Erythrocytes; Humans; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Rats; Spectrophotometry, Ultraviolet; Time Factors

1983
Studies of the pharmacokinetic properties of nimorazole.
    British journal of cancer, 1983, Volume: 48, Issue:1

    Topics: Adult; Aged; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Half-Life; Humans; Intestinal Absorption; Male; Middle Aged; Neoplasms; Nimorazole; Nitroimidazoles; Time Factors

1983
Phase I trial of intravenous L-phenylalanine mustard plus the sensitizer misonidazole.
    Cancer research, 1983, Volume: 43, Issue:10

    Topics: Adult; Aged; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Male; Melphalan; Middle Aged; Misonidazole; Neoplasms; Nitroimidazoles

1983
Structure-activity relationships in the development of hypoxic cell radiosensitizers. III. Effects of basic substituents in nitroimidazole sidechains.
    International journal of radiation biology and related studies in physics, chemistry, and medicine, 1980, Volume: 38, Issue:6

    Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Chemical Phenomena; Chemistry; Cricetinae; Cricetulus; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Structure-Activity Relationship

1980
Evaluation of the bioavailability of misonidazole (NSC#261037) in capsule and tablet form and pharmacologic effects of daily dosage.
    International journal of radiation oncology, biology, physics, 1982, Volume: 8, Issue:2

    Topics: Adult; Biological Availability; Capsules; Drug Administration Schedule; Drug Evaluation; Half-Life; Humans; Misonidazole; Neoplasms; Nitroimidazoles; Tablets

1982
The radiosensitizer Ro 03-8799 and the concentrations which may be achieved in human tumours: a preliminary study.
    British journal of cancer, 1982, Volume: 46, Issue:5

    Topics: Adult; Aged; Female; Half-Life; Humans; Male; Necrosis; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents

1982
I.V. misonidazole (NSC 261037). Report of initial clinical experience.
    Cancer clinical trials, 1981, Volume: 4, Issue:1

    Topics: Adult; Aged; Bile; Female; Humans; Injections, Intravenous; Kinetics; Male; Middle Aged; Misonidazole; Neoplasms; Nitroimidazoles

1981
Misonidazole dose and tumor level relationships. Effects of individual variation in rate of misonidazole metabolism and absorption from the gastrointestinal tract.
    Cancer clinical trials, 1981, Volume: 4, Issue:1

    Topics: Biological Availability; Dose-Response Relationship, Drug; Half-Life; Humans; Intestinal Absorption; Kinetics; Misonidazole; Neoplasms; Nitroimidazoles

1981
Clinical trials of misonidazole in the United States.
    Cancer clinical trials, 1981, Volume: 4, Issue:1

    Topics: Drug Evaluation; Head and Neck Neoplasms; Humans; Misonidazole; Neoplasm Metastasis; Neoplasms; Nervous System Diseases; Nitroimidazoles

1981
The concentration of desmethylmisonidazole in human tumours and in cerebrospinal fluid.
    British journal of cancer, 1981, Volume: 43, Issue:3

    Topics: Breast Neoplasms; Female; Humans; Misonidazole; Necrosis; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents; Time Factors; Uterine Cervical Neoplasms

1981
Causes of apparent low levels of misonidazole in human tumours.
    Clinical radiology, 1980, Volume: 31, Issue:2

    Topics: Adipose Tissue; Animals; Brain Neoplasms; Humans; In Vitro Techniques; Liver Neoplasms; Mammary Neoplasms, Experimental; Mice; Misonidazole; Muscles; Neoplasms; Nitroimidazoles; Rats

1980
Pharmacokinetic and tumour-penetration properties of the hypoxic cell radiosensitizer desmethylmisonidazole (Ro 05-Ro-9963) in dogs.
    British journal of cancer, 1980, Volume: 41, Issue:2

    Topics: Animals; Biological Availability; Dog Diseases; Dogs; Half-Life; Kinetics; Male; Misonidazole; Neoplasms; Nitroimidazoles

1980
The development of some nitroimidazoles as hypoxic cell sensitizers.
    Cancer clinical trials, 1980,Spring, Volume: 3, Issue:1

    Topics: Cells, Cultured; Dose-Response Relationship, Drug; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Structure-Activity Relationship

1980
Misonidazole in fractionated radiotherapy: are many small fractions best?
    The British journal of radiology, 1980, Volume: 53, Issue:634

    Topics: Animals; Cell Survival; Drug Administration Schedule; Female; Male; Misonidazole; Models, Biological; Neoplasms; Nitroimidazoles; Oxygen; Radiotherapy Dosage

1980
Pharmacokinetics of hypoxic cell radiosensitizers: a review.
    Cancer clinical trials, 1980,Fall, Volume: 3, Issue:3

    Topics: Administration, Oral; Animals; Cell Membrane Permeability; Dogs; Dose-Response Relationship, Drug; Female; Half-Life; Humans; Injections, Intraperitoneal; Injections, Intravenous; Kinetics; Male; Membrane Lipids; Mice; Models, Biological; Neoplasms; Nerve Tissue; Nitroimidazoles; Radiation-Sensitizing Agents; Structure-Activity Relationship; Tissue Distribution

1980
Nature and incidence of misonidazole-produced ototoxicity.
    Archives of otolaryngology (Chicago, Ill. : 1960), 1981, Volume: 107, Issue:1

    Topics: Adult; Aged; Female; Hearing Loss, Sensorineural; Humans; Male; Middle Aged; Misonidazole; Neoplasms; Nitroimidazoles

1981
Potential bioreductively activated hypoxia probes and post-irradiation radiosensitizers related to NITP.
    Anti-cancer drug design, 1995, Volume: 10, Issue:3

    Topics: Biomarkers; Cell Hypoxia; Cells, Cultured; Magnetic Resonance Spectroscopy; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents; Spectrophotometry, Infrared; Theophylline

1995
Distribution of the hypoxia marker CCI-103F in canine tumors.
    International journal of radiation oncology, biology, physics, 1994, Mar-01, Volume: 28, Issue:4

    Topics: Animals; Cell Hypoxia; Dog Diseases; Dogs; Female; Male; Neoplasms; Nitroimidazoles

1994
Bioreductive drugs for cancer therapy: the search for tumor specificity.
    International journal of radiation oncology, biology, physics, 1994, May-15, Volume: 29, Issue:2

    Topics: Animals; Antineoplastic Agents; Humans; Neoplasms; Nitric Oxide; Nitroimidazoles; Oxidation-Reduction; Photochemotherapy; Porfiromycin; Prodrugs; Tirapazamine; Triazines

1994
An enzyme-linked immunosorbent assay for hypoxia marker binding in tumours.
    British journal of cancer, 1994, Volume: 69, Issue:1

    Topics: Animals; Biomarkers, Tumor; Calibration; Dogs; Enzyme-Linked Immunosorbent Assay; Hypoxia; Neoplasms; Nitroimidazoles; Tissue Distribution; Tritium

1994
Synthesis and evaluation of a boronated nitroimidazole for boron neutron capture therapy.
    Journal of medicinal chemistry, 1996, Mar-29, Volume: 39, Issue:7

    Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Cell Line; Cell Survival; Cricetinae; Dose-Response Relationship, Drug; Magnetic Resonance Spectroscopy; Molecular Structure; Neoplasms; Nitroimidazoles

1996
Multicellular membranes as an in vitro model for extravascular diffusion in tumours.
    The British journal of cancer. Supplement, 1996, Volume: 27

    Topics: Acridines; Animals; Cell Hypoxia; Cell Membrane; Cricetinae; Cricetulus; Diffusion; In Vitro Techniques; Misonidazole; Neoplasms; Nitroimidazoles; Phenanthridines

1996
Measurement of hypoxia in human tumours by non-invasive spect imaging of iodoazomycin arabinoside.
    The British journal of cancer. Supplement, 1996, Volume: 27

    Topics: Cell Hypoxia; Humans; Neoplasms; Nitroimidazoles; Tomography, Emission-Computed, Single-Photon

1996
BMS181321 accumulation in rodent and human cells: the role of P-glycoprotein.
    The British journal of cancer. Supplement, 1996, Volume: 27

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Hypoxia; CHO Cells; Cricetinae; Drug Resistance; Humans; Neoplasms; Nitroimidazoles; Organotechnetium Compounds; Rats

1996
Development of new markers for hypoxic cells: [131I]Iodomisonidazole and [131I]Iodoerythronitroimidazole.
    Journal of drug targeting, 1996, Volume: 4, Issue:1

    Topics: Animals; Breast Neoplasms; Cell Hypoxia; Female; Iodine Radioisotopes; Lung Neoplasms; Mice; Mice, Inbred BALB C; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents; Radionuclide Imaging; Rats; Rats, Inbred F344; Tissue Distribution; Tumor Cells, Cultured

1996
Should benznidazole be used in chronic Chagas' disease?
    Lancet (London, England), 1997, Mar-01, Volume: 349, Issue:9052

    Topics: Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Follow-Up Studies; Humans; Neoplasms; Nitroimidazoles; Trypanocidal Agents

1997
Quantification of CCI-103F labeling heterogeneity in canine solid tumors.
    International journal of radiation oncology, biology, physics, 1997, Feb-01, Volume: 37, Issue:3

    Topics: Analysis of Variance; Animals; Biomarkers; Cell Hypoxia; Dog Diseases; Dogs; Neoplasms; Nitroimidazoles; Oxygen; Reproducibility of Results

1997
Longevity of pimonidazole adducts in spontaneous canine tumors as an estimate of hypoxic cell lifetime.
    Radiation research, 1997, Volume: 148, Issue:1

    Topics: Animals; Cell Survival; DNA Adducts; DNA, Neoplasm; Dog Diseases; Dogs; Hypoxia; Neoplasms; Nitroimidazoles

1997
Hypoxia marker labeling in tumor biopsies: quantification of labeling variation and criteria for biopsy sectioning.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1997, Volume: 44, Issue:2

    Topics: Animals; Biopsy; Cell Hypoxia; Dog Diseases; Dogs; Neoplasms; Nitroimidazoles

1997
Higher incidence of malignant neoplasms after heart transplantation for treatment of chronic Chagas' heart disease.
    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 1998, Volume: 17, Issue:4

    Topics: Adult; Carcinoma, Squamous Cell; Chagas Cardiomyopathy; Chemoprevention; Chronic Disease; Cocarcinogenesis; Cyclosporine; Female; Follow-Up Studies; Heart Failure; Heart Transplantation; Humans; Immunosuppressive Agents; Incidence; Lung Diseases; Lymphoproliferative Disorders; Male; Mutagens; Neoplasms; Neurilemmoma; Nitroimidazoles; Recurrence; Sarcoma, Kaposi; Skin Neoplasms; Survival Rate; Trypanocidal Agents

1998
Identification of nonproliferating but viable hypoxic tumor cells in vivo.
    Cancer research, 1998, Aug-15, Volume: 58, Issue:16

    Topics: Animals; Bromodeoxyuridine; Cell Division; Cell Hypoxia; Cell Separation; Flow Cytometry; Humans; Mice; Mice, SCID; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents; Transplantation, Heterologous; Tumor Cells, Cultured

1998
Prediction of tumor response to therapy: molecular markers and the microenvironment. Apoptosis and chips: an overview of the proceedings.
    Radiation research, 2000, Volume: 154, Issue:2

    Topics: Apoptosis; Biomarkers, Tumor; Biopsy; Cell Cycle; Cell Hypoxia; Cell Survival; Comet Assay; DNA Ligases; Enzyme Activation; Genes, ras; Humans; Immunohistochemistry; Neoplasm Metastasis; Neoplasm Proteins; Neoplasms; Nitroimidazoles; Oligonucleotide Array Sequence Analysis; Predictive Value of Tests; Radiation Tolerance; Radiotherapy Dosage; Tumor Cells, Cultured

2000
Measuring hypoxia in solid tumours--is there a gold standard?
    Acta oncologica (Stockholm, Sweden), 2001, Volume: 40, Issue:8

    Topics: Biopsy, Needle; Comet Assay; Humans; Hypoxia; Microelectrodes; Neoplasms; Nitroimidazoles; Palliative Care; Predictive Value of Tests; Radiation-Sensitizing Agents; Radiotherapy; Reference Values

2001
Why do hypoxic cells behave badly?
    The Lancet. Oncology, 2000, Volume: 1

    Topics: Cell Hypoxia; Humans; Immunohistochemistry; Infusions, Intravenous; Neoplasm Invasiveness; Neoplasms; Nitroimidazoles; Oxygen; Prognosis; Sensitivity and Specificity; Tumor Cells, Cultured

2000
Hypoxic-cell sensitisers.
    Lancet (London, England), 1978, Sep-16, Volume: 2, Issue:8090

    Topics: Cell Survival; Humans; Hypoxia; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen Consumption; Radiation Tolerance

1978
Hypoxic-cell sensitisers.
    Lancet (London, England), 1978, Oct-21, Volume: 2, Issue:8095

    Topics: Dose-Response Relationship, Drug; Drug Evaluation; Humans; Hypoxia; Metronidazole; Misonidazole; Neoplasms; Nitroimidazoles

1978
[Clinical experiences with the radiation-sensitizing agent misonidazole].
    Strahlentherapie. Sonderbande, 1978, Volume: 75

    Topics: Brain Neoplasms; Cardiovascular System; Central Nervous System; Digestive System; Drug Eruptions; Eye; Female; Humans; Liver; Male; Misonidazole; Neoplasms; Nitroimidazoles

1978
The application in radiation therapy of substances which modify cellular radiation response.
    Cancer, 1977, Volume: 40, Issue:1 Suppl

    Topics: Amifostine; Animals; Drug Evaluation; Drug Therapy, Combination; Humans; Metronidazole; Neoplasms; Neoplasms, Experimental; Nitroimidazoles; Oxygen Consumption; Radiation-Protective Agents; Radiation-Sensitizing Agents; Radiotherapy Dosage

1977
Developments in radiotherapy other than heavy particle beams.
    International journal of radiation oncology, biology, physics, 1977, Volume: 3

    Topics: Animals; Brain Neoplasms; Energy Transfer; Fast Neutrons; Female; Glioblastoma; Hot Temperature; Humans; Mammary Neoplasms, Experimental; Metronidazole; Mice; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents; Radiotherapy Dosage; Radiotherapy, High-Energy; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; X-Rays

1977
The neurotoxicity of misonidazole and its relationship to dose, half-life and concentration in the serum.
    The British journal of cancer. Supplement, 1978, Volume: 3

    Topics: Drug Administration Schedule; Half-Life; Humans; Neoplasms; Nitroimidazoles; Peripheral Nervous System Diseases; Radiation-Sensitizing Agents

1978
Peripheral neuropathy related to misonidazole: incidence and pathology.
    The British journal of cancer. Supplement, 1978, Volume: 3

    Topics: Drug Administration Schedule; Female; Humans; Middle Aged; Neoplasms; Neural Conduction; Nitroimidazoles; Peripheral Nervous System Diseases; Radiation-Sensitizing Agents; Sural Nerve

1978
The optimum regime for the administration of misonidazole and the establishment of multi-centre clinical trials.
    The British journal of cancer. Supplement, 1978, Volume: 3

    Topics: Drug Administration Schedule; Humans; Neoplasms; Nitroimidazoles; Peripheral Nervous System Diseases; Radiation-Sensitizing Agents; Research Design

1978
Electroneurographic investigations of misonidazole polyneuropathy.
    European neurology, 1979, Volume: 18, Issue:6

    Topics: Action Potentials; Adult; Aged; Female; Humans; Male; Middle Aged; Misonidazole; Motor Neurons; Neoplasms; Nerve Fibers; Neural Conduction; Nitroimidazoles; Peripheral Nerves; Peripheral Nervous System Diseases; Peroneal Nerve; Sural Nerve; Time Factors

1979
Metronidazole (Flagyl), misonidazole (Ro 07-0582), iron, zinc and sulphur compounds in cancer therapy.
    The British journal of cancer. Supplement, 1978, Volume: 3

    Topics: Cysteamine; Cysteine; Ferrous Compounds; Glutathione; Kinetics; Metronidazole; Neoplasms; Nitroimidazoles; Oxidation-Reduction; Zinc

1978
Some aspects of the metabolism of misonidazole.
    The British journal of cancer. Supplement, 1978, Volume: 3

    Topics: Animals; Chromatography, High Pressure Liquid; Humans; Mice; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents

1978
The hypoxic cell sensitizer programme in the United States.
    The British journal of cancer. Supplement, 1978, Volume: 3

    Topics: Aged; Drug Evaluation; Female; Humans; Male; Middle Aged; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents; United States

1978
Clinical experience with misonidazole.
    The British journal of cancer. Supplement, 1978, Volume: 3

    Topics: Digestive System; Humans; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents; Skin

1978
The penetration of misonidazole into spontaneous canine tumours.
    British journal of cancer, 1979, Volume: 40, Issue:2

    Topics: Adenocarcinoma; Anesthesia, Intravenous; Animals; Carcinoma, Squamous Cell; Disease Models, Animal; Dog Diseases; Dogs; Female; Fibrosarcoma; Half-Life; Lymphoma, Non-Hodgkin; Male; Mammary Glands, Animal; Meningioma; Misonidazole; Neoplasms; Nitroimidazoles; Osteosarcoma; Pentobarbital

1979
[New aspects of radiotherapy. I. Significance of hypoxia in irradiation of solid tumors].
    Ugeskrift for laeger, 1979, Apr-09, Volume: 141, Issue:15

    Topics: Dose-Response Relationship, Radiation; Hot Temperature; Humans; Hyperbaric Oxygenation; Hypoxia; Misonidazole; Neoplasms; Nitroimidazoles

1979
Distribution of misonidazole in human tumours and normal tissues.
    British journal of cancer, 1979, Volume: 39, Issue:5

    Topics: Brain Neoplasms; Breast Neoplasms; Female; Genital Neoplasms, Female; Humans; Male; Misonidazole; Neoplasms; Nitroimidazoles; Thyroid Diseases; Tissue Distribution; Urinary Bladder Neoplasms

1979
Radiosensitizers.
    Antibiotics and chemotherapy, 1978, Volume: 23

    Topics: Animals; Cell Survival; Humans; In Vitro Techniques; Mice; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents; Razoxane

1978
Hypoxic cell sensitization by misonidazole in vivo and in vitro.
    The British journal of radiology, 1978, Volume: 51, Issue:604

    Topics: Cell Line; Dose-Response Relationship, Drug; Hypoxia; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents

1978
Use of metronidazole and other nitroimidazole drugs in cancer therapy.
    Cancer treatment reports, 1978, Volume: 62, Issue:9

    Topics: Animals; Humans; Metronidazole; Neoplasms; Nitroimidazoles

1978
Treatment of amoebiasis and giardiasis.
    The Medical journal of Australia, 1978, Sep-09, Volume: 2, Issue:6

    Topics: Child; Dysentery, Amebic; Giardiasis; Humans; Metronidazole; Neoplasms; Nitroimidazoles; Research Design; Tinidazole

1978
Monitoring salivary misonidazole in man: a possible alternative to plasma monitoring.
    British journal of cancer, 1978, Volume: 38, Issue:6

    Topics: Adult; Aged; Bronchial Neoplasms; Female; Half-Life; Humans; Male; Metabolic Clearance Rate; Middle Aged; Misonidazole; Neoplasm Metastasis; Neoplasms; Nitroimidazoles; Saliva; Skin Neoplasms

1978
Clinical phase I study of the hypoxic cell radiosensitizer RO-07-0582, a 2-nitroimidazole derivative.
    Radiology, 1977, Volume: 122, Issue:3

    Topics: Chondrosarcoma; Drug Evaluation; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents

1977
Radiosensitization of hypoxic tumor cells by simultaneous administration of hyperthermia and nitroimidazoles.
    Radiation research, 1977, Volume: 70, Issue:2

    Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Survival; Deoxyuridine; Female; Hyperthermia, Induced; Hypoxia; Leukemia L1210; Metronidazole; Mice; Mice, Inbred Strains; Neoplasms; Neoplasms, Experimental; Nitroimidazoles; Radiation Tolerance; Radiation-Sensitizing Agents; Sarcoma

1977
Clinical testing of the radiosensitizer Ro 07-0582: experience with multiple doses.
    British journal of cancer, 1977, Volume: 35, Issue:5

    Topics: Adult; Aged; Humans; Middle Aged; Neoplasms; Nervous System Diseases; Nitroimidazoles; Radiation-Sensitizing Agents

1977
Radiosensitizers of hypoxic cells in solid tumors.
    Cancer treatment reviews, 1976, Volume: 3, Issue:4

    Topics: Animals; Cells, Cultured; Cricetinae; Dose-Response Relationship, Drug; Fast Neutrons; Mammary Neoplasms, Experimental; Metronidazole; Mice; Neoplasm Metastasis; Neoplasms; Neoplasms, Experimental; Nitroimidazoles; Oxygen Consumption; Radiation-Sensitizing Agents; Radiotherapy Dosage

1976
Non-invasive assessment of human tumour hypoxia with 123I-iodoazomycin arabinoside: preliminary report of a clinical study.
    British journal of cancer, 1992, Volume: 65, Issue:1

    Topics: Adult; Aged; Carcinoma, Small Cell; Female; Half-Life; Humans; Hypoxia; Iodine Radioisotopes; Lung Neoplasms; Male; Middle Aged; Neoplasms; Nitroimidazoles; Tomography, Emission-Computed

1992
Development of an ELISA for the detection of 2-nitroimidazole hypoxia markers bound to tumor tissue.
    International journal of radiation oncology, biology, physics, 1992, Volume: 22, Issue:3

    Topics: Animals; Cell Hypoxia; Dogs; Enzyme-Linked Immunosorbent Assay; Liposarcoma; Neoplasms; Nitroimidazoles; Sarcoma, Synovial

1992
Immunohistochemical detection of a hypoxia marker in spontaneous canine tumours.
    British journal of cancer, 1990, Volume: 62, Issue:6

    Topics: Animals; Cell Hypoxia; Dog Diseases; Dogs; Immunohistochemistry; Neoplasms; Nitroimidazoles; Staining and Labeling

1990
Nitroheterocyclic compounds as radiation sensitizers and bioreductive drugs.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1991, Volume: 20 Suppl 1

    Topics: Antineoplastic Agents; Combined Modality Therapy; Humans; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents

1991
Quantitation of hypoxia in multicellular spheroids by video image analysis.
    International journal of radiation oncology, biology, physics, 1989, Volume: 16, Issue:4

    Topics: Autoradiography; Cell Aggregation; Cell Line; Fluorescence; Humans; Image Processing, Computer-Assisted; Immunoenzyme Techniques; Neoplasms; Nitroimidazoles; Oxygen

1989
The uptake of the radiosensitizing compound Ro 03-8799 (Pimonidazole) in human tumors.
    International journal of radiation oncology, biology, physics, 1989, Volume: 16, Issue:4

    Topics: Breast Neoplasms; Female; Humans; Melanoma; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents; Rectal Neoplasms; Uterine Cervical Neoplasms

1989
A phase I study of the combination of two hypoxic cell radiosensitizers, Ro 03-8799 and SR-2508: toxicity and pharmacokinetics.
    International journal of radiation oncology, biology, physics, 1986, Volume: 12, Issue:7

    Topics: Adolescent; Adult; Aged; Combined Modality Therapy; Drug Combinations; Drug Evaluation; Etanidazole; Humans; Middle Aged; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents

1986
Concentrations achieved in human tumors after administration of misonidazole, SR-2508 and Ro 03-8799.
    International journal of radiation oncology, biology, physics, 1986, Volume: 12, Issue:7

    Topics: Aged; Etanidazole; Female; Humans; Male; Middle Aged; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents

1986
The multi-dose clinical tolerance and pharmacokinetics of the combined radiosensitizers, Ro 03-8799 (pimonidazole) and SR 2508 (etanidazole).
    International journal of radiation oncology, biology, physics, 1988, Volume: 15, Issue:5

    Topics: Adult; Aged; Combined Modality Therapy; Drug Therapy, Combination; Etanidazole; Humans; Middle Aged; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents

1988
Oxygen dependence of hematoporphyrin derivative-induced photoinactivation of Chinese hamster cells.
    Cancer research, 1985, Volume: 45, Issue:5

    Topics: Animals; Cell Line; Cell Survival; Cricetinae; Cricetulus; Etanidazole; Hematoporphyrins; Neoplasms; Nitroimidazoles; Oxygen; Photochemotherapy

1985
Facing fearful odds--a conference summary.
    International journal of radiation oncology, biology, physics, 1986, Volume: 12, Issue:7

    Topics: Antineoplastic Agents; Combined Modality Therapy; Drug Synergism; Glutathione; Humans; Hyperbaric Oxygenation; Neoplasms; Nitroimidazoles; Radiation-Protective Agents; Radiation-Sensitizing Agents

1986
Radiosensitization by tinidazole: pharmacokinetic study.
    International journal of clinical pharmacology research, 1986, Volume: 6, Issue:4

    Topics: Drug Administration Schedule; Humans; Kinetics; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents; Tinidazole

1986
Safety of nitroimidazoles.
    Scandinavian journal of infectious diseases. Supplementum, 1985, Volume: 46

    Topics: Abnormalities, Drug-Induced; Animals; Chromosome Aberrations; Cricetinae; Dose-Response Relationship, Drug; Female; Humans; Infant, Newborn; Male; Metronidazole; Mice; Mutagenicity Tests; Neoplasms; Nitroimidazoles; Pregnancy; Rats; Risk; Structure-Activity Relationship; Tinidazole

1985
A clinical phase I toxicity study of Ro 03-8799: plasma, urine, tumour and normal brain pharmacokinetics.
    The British journal of radiology, 1986, Volume: 59, Issue:698

    Topics: Astrocytoma; Brain; Brain Diseases; Brain Neoplasms; Dose-Response Relationship, Drug; Drug Evaluation; Humans; Kinetics; Neoplasms; Nitroimidazoles

1986
Kinetic aspects of misonidazole and its major metabolite in radiotherapy.
    Human toxicology, 1985, Volume: 4, Issue:4

    Topics: Adult; Aged; Female; Half-Life; Humans; Kinetics; Male; Middle Aged; Misonidazole; Neoplasms; Nitroimidazoles

1985