Compounds > azomycin
Page last updated: 2024-08-21

azomycin and Lung Neoplasms

azomycin has been researched along with Lung Neoplasms in 82 studies

Research

Studies (82)

TimeframeStudies, this research(%)All Research%
pre-199034 (41.46)18.7374
1990's7 (8.54)18.2507
2000's7 (8.54)29.6817
2010's33 (40.24)24.3611
2020's1 (1.22)2.80

Authors

AuthorsStudies
Cheng, W; Jia, T; Miao, R; Shao, J; Zeng, L; Zhang, C; Zhang, J; Zhao, Y; Zhu, H1
Dąbrowski, JM; Elas, M; Gonet, M; Karwicka, M; Pucelik, B1
Bol, A; Di Perri, D; Geets, X; Hanin, FX; Janssens, G; Labar, D; Lee, JA; Robert, A; Sterpin, E2
Bettinardi, V; Compierchio, A; Doglioni, C; Fallanca, F; Gianolli, L; Incerti, E; Mapelli, P; Masiello, V; Negri, G; Picchio, M; Rossetti, F1
Bettinardi, V; Coliva, A; Compierchio, A; Doglioni, C; Fallanca, F; Gianolli, L; Incerti, E; Mapelli, P; Negri, G; Picchio, M; Rossetti, F; Savi, A1
Brolo, AG; Hindi, MN; Jirasek, A; Lum, JJ; Nicholson, LM; Pavey, N; Van Nest, SJ1
Bahce, I; Boellaard, R; Lammertsma, AA; Raijmakers, P; Schuit, RC; Smit, EF; van Velden, FH; Verwer, EE; Windhorst, AD; Yaqub, M1
Bollineni, VR; de Groot, EH; Groen, HJ; Kerner, GS; Koole, MJ; Langendijk, JA; Luurtsema, G; Pruim, J; Steenbakkers, RJ; Widder, J; Wiegman, EM; Willemsen, AT1
Hu, M; Kong, L; Mu, D; Xing, L; Yang, G; Yang, W; Yu, J1
Ball, D; Binns, D; Blum, R; Bressel, M; Callahan, J; Eu, P; Hicks, RJ; MacManus, MP; Rischin, D; Roselt, P; Segard, T; Trinkaus, ME1
Cerecetto, H; Dematteis, S; Fernández, S; Giglio, J; Rey, A1
Bahce, I; Boellaard, R; Hoekstra, OS; Lammertsma, AA; Raijmakers, P; Schuit, RC; Smit, EF; van Velden, FH; Verwer, EE; Windhorst, AD; Yaqub, M1
Bollineni, VR; Brouwer, CL; Groen, HJ; Halmos, GB; Koole, MJ; Langendijk, JA; Oosting, SF; Pruim, J; Steenbakkers, RJ; Vlasman, R; Widder, J; Wiegman, EM1
Duan, X; Li, J; Li, XF; Ma, Y; Postel, GC; Wang, F; Wang, X; Yin, X; Zhang, G; Zheng, H1
Biemans, R; Dubois, LJ; Hart, CP; Lambin, P; Lieuwes, NG; Peeters, SG; Sun, JD; van Elmpt, W; van Stiphout, RG; Windhorst, AD; Yaromina, A; Zegers, CM1
Brunetti, JC; Chien, D; Kolb, H; Lambin, P; Moon, DH; Srinivas, SM; Subramaniam, RM; Szardenings, K; van Elmpt, W; Waxman, A; Zegers, CM1
Horiike, A; Inubushi, M; Koizumi, M; Nishio, M; Ohyanagi, F; Saga, T; Tanimoto, K; Yanagitani, N; Yoshikawa, K; Zhang, MR1
Das, M; Dingemans, AC; Even, AJG; Lambin, P; Mottaghy, FM; Oellers, M; Reymen, B; Troost, EGC; van Elmpt, W; Wildberger, JE; Zegers, CML1
Bahce, I; Boellaard, R; de Langen, AJ; Hoekstra, OS; Huisman, MC; Iqbal, R; Kramer, GM; Lammertsma, AA; van Velden, FH; Verwer, EE; Windhorst, AD1
Asamura, H; Fujii, H; Hayashi, Y; Kamiyama, I; Kinoshita, T; Ohtsuka, T1
Ahluwalia, D; Ferraro, DJ; Hart, CP; Jung, D; Liu, Q; Matteucci, MD; Sun, JD; Wang, Y1
Chu, T; Lin, X; Luo, R; Luo, Z; Wang, Y; Yang, Z; Zhu, H1
Hu, X; Huang, Y; Wang, S; Wei, Y; Yu, J; Yu, Q; Yuan, S; Zhao, S; Zhao, W; Zhu, S1
Ikemura, Y; Kurihara, R; Tanabe, K1
Chen, Q; Guan, Y; Li, X; Liu, S; Zhang, Q1
Abrams, DN; Kumar, P; McEwan, AJ; Postema, EJ; Riauka, TA; Richmond, DA; Wiebe, LI1
Ali, M; Babur, M; Bloomer, WD; Cawthorne, C; Julyan, PJ; Lunt, SJ; Papadopoulou, MV; Price, PM; Smigova, A; Stratford, IJ; Telfer, BA; Williams, KJ1
An, H; Engenhart-Cabillic, R; Eul, BG; Fokas, E; Hänze, J; Heverhagen, JT; Kamlah, F; Keil, B; Lang, N; Rose, F1
Fu, Z; Han, AQ; Hu, M; Kong, L; Ma, L; Yang, GR; Yang, WF; Yu, JM; Zhao, SQ; Zheng, JS1
Hu, M; Li, L; Yang, G; Yu, J; Zhao, W; Zhu, H1
Cecic, IK; Erler, JT; Felsher, D; Giaccia, AJ; Graves, EE; Le, QT; Sayles, L; Sweet-Cordero, A; Tran, PT; Vilalta, M1
Ellingsen, C; Galappathi, K; Ovrebø, KM; Rofstad, EK1
Barber, PR; Bell, A; Burke, M; Daley, FM; Finch, J; Goh, V; Hoskin, PJ; Kozarski, R; Mandeville, HC; Ng, QS; Pierce, G; Townsend, ER; Vojnovic, B1
Civelek, AC; Huang, T; Jiang, H; Li, J; Li, XF; Ng, CK; Postel, GC; Shen, B1
Ashino, H; Hazato, T; Hori, H; Inayama, S; Nagasawa, H; Shimamura, M; Uto, Y; Yamamoto, Y1
Büchler, MW; Büchler, P; Friess, H; Hines, OJ; Lavey, RS; Reber, HA; Tomlinson, J1
Binns, D; Cullinane, C; Hicks, RJ; McArthur, GA; Roselt, P; Solomon, B; Weibe, LI1
Fukuda, H; Funaki, Y; Furumoto, S; Hakamatsuka, T; Ishikawa, Y; Ito, M; Iwata, R; Jingu, K; Kaneta, T; Nakata, E; Nakayama, K; Takahashi, S; Takai, Y; Tsujitani, M; Watanuki, S; Yamada, S; Yasuda, H1
Ito, M; Iwata, R; Kaneta, T; Nakayama, K; Sasaki, T; Takahashi, S; Takai, Y; Tsujitani, M; Yamada, S; Yamaya, M; Yanagihara, K; Yasuda, H1
Hansen, HS; Hansen, JM; Kamieniecka, Z; Køhler, O; Melgaard, B; Paulson, OB; Pedersen, AG; Tang, X; Trojaborg, W1
Heller, EH; Mameghan, H1
Chaplin, DJ; Jinks, S; Millar, BC1
Byhardt, RW; Cox, JD; Greenberg, M; Komaki, R1
Hansen, HH; Kjaer, M; Panduro, J; Wolff-Jensen, J1
Hunter, N; Ito, H; Milas, L1
Onoyama, Y1
Clarke, C; Dawson, KB; Sheldon, PW; Simmons, DJ; Simpson, W1
Irvin, CG; Nierenburg, M; Rockwell, S1
Adams, GE; Ahmed, I; Chaplin, DJ; Sheldon, PW1
Breccia, A; Busutti, L; Gattavecchia, E; Stagni, G1
Mitsuhashi, N; Mogi, K; Nakajima, N; Niibe, H; Okazaki, A; Saito, K; Sakaino, K; Sudo, H; Suzuki, Y; Yonome, I1
Asakura, H; Kanazawa, A; Maruhashi, A; Mashima, Y1
Adams, GE; Ahmed, I; Chaplin, DJ; Sheldon, PW; Stratford, IJ1
Bleehen, NM; Jones, DH; Walton, MI; Workman, P1
Abe, M; Dodo, Y; Ono, K; Takahashi, M1
Abe, M; Dodo, Y; Hiraoka, M; Jo, S; Nishidai, T; Ono, K; Takahashi, M1
Asakawa, H; Hoshino, T; Watarai, J1
Kylmämaa, TT; Mäntylä, MJ; Nordman, EM; Ruotsalainen, PJ1
Carella, RJ; Concannon, JP; Perez, CA; Phillips, TL; Simpson, JR1
Hansen, HS; Kamieniecka, Z; Melgaard, B; Paulson, OB; Pedersen, AG; Tang, X; Trojaborg, W1
Kochanski, K; Siemann, DW1
Courtenay, VD; Mills, J; Peacock, JH; Rose, CM; Spooner, D; Stephens, TC1
Allalunis, MJ; Meeker, BE; Pedersen, JE; Turner, AR; Urtasun, RC1
Chapman, JD; Golberg, LE; Groshar, D; Hoskinson, M; Mannan, RH; McEwan, AJ; Mercer, JR; Parliament, MB; Urtasun, RC; Wiebe, LI1
Cherif, A; Harrod, VL; Inoue, T; Kim, CG; Kim, EE; Kuang, LR; Newman, RA; Nornoo, A; Podoloff, DA; Wallace, S; Yang, DJ1
Hori, H; Inayama, S; Inomata, T; Kasai, S; Kuwasaka, H; Nagasawa, H; Nishioka, A; Ogawa, Y; Oshodani, T; Yoshida, S1
Hamada, N; Hori, H; Inayama, S; Inomata, T; Itoh, S; Kariya, S; Nagasawa, H; Nishioka, A; Ogawa, Y; Yoshida, S1
Hori, H; Inayama, S; Inomata, T; Kasai, S; Kuwasaka, H; Masui, M; Nagasawa, H; Oka, S; Oshodani, T; Uto, Y; Yamashita, M1
Guérin, RA1
Peckham, MJ; Stanley, JA; Steel, GG1
Dawen, PJ; Peckham, MJ; Steel, GG1
Bugden, RD; Peckham, MJ; Pedersen, JE; Smith, MR1
Ash, DV; Peckham, MJ; Steel, GG1
Dische, S; Errington, LM; Gray, AJ; Thomlinson, RH1
Chapman, JD; Golberg, L; Mannan, RH; McEwan, AJ; Mercer, JR; Parliament, MB; Urtasun, RC; Wiebe, LI1
Bertoni, F; Breccia, A; Busutti, L; Falcone, F; Ferri, E1
Bleehen, NM; Newman, HF; Smithen, CE; Ward, R; Workman, P1
Canal, P; Laurent, F; Soula, G1
Chapman, JD; Kanclerz, A1
Abe, M; Fushiki, M; Nishidai, T; Ono, K; Sasai, K; Shibamoto, Y; Takahashi, M; Tsutsui, K1

Reviews

1 review(s) available for azomycin and Lung Neoplasms

ArticleYear
Radiation sensitizers.
    Cancer, 1976, Volume: 37, Issue:4 Suppl

    Topics: Animals; Antineoplastic Agents; Bromodeoxycytidine; Bromodeoxyuridine; Carcinoma; Deoxyuridine; Dogs; Dose-Response Relationship, Radiation; Floxuridine; Humans; Hypoxia; Idoxuridine; Lung Neoplasms; Methotrexate; Metronidazole; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents; Research; Sarcoma, Experimental; Skin

1976

Trials

16 trial(s) available for azomycin and Lung Neoplasms

ArticleYear
Hypoxia imaging with 18F-fluoroerythronitroimidazole integrated PET/CT and immunohistochemical studies in non-small cell lung cancer.
    Clinical nuclear medicine, 2013, Volume: 38, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Female; Glucose; Humans; Immunohistochemistry; Lung Neoplasms; Male; Middle Aged; Multimodal Imaging; Neovascularization, Pathologic; Nitroimidazoles; Positron-Emission Tomography; Survival Analysis; Tomography, X-Ray Computed

2013
Imaging of hypoxia with 18F-FAZA PET in patients with locally advanced non-small cell lung cancer treated with definitive chemoradiotherapy.
    Journal of medical imaging and radiation oncology, 2013, Volume: 57, Issue:4

    Topics: Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Chemoradiotherapy; Female; Humans; Lung Neoplasms; Male; Middle Aged; Nitroimidazoles; Positron-Emission Tomography; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Treatment Outcome

2013
Repeatability of hypoxia PET imaging using [¹⁸F]HX4 in lung and head and neck cancer patients: a prospective multicenter trial.
    European journal of nuclear medicine and molecular imaging, 2015, Volume: 42, Issue:12

    Topics: Aged; Biological Transport; Cell Hypoxia; Female; Head and Neck Neoplasms; Humans; Lung Neoplasms; Male; Middle Aged; Nitroimidazoles; Positron-Emission Tomography; Prospective Studies; Reproducibility of Results; Triazoles

2015
Prognostic value of (18) F-fluoroazomycin arabinoside PET/CT in patients with advanced non-small-cell lung cancer.
    Cancer science, 2015, Volume: 106, Issue:11

    Topics: Adult; Aged; Carcinoma, Non-Small-Cell Lung; Disease-Free Survival; Female; Fluorodeoxyglucose F18; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Male; Middle Aged; Multimodal Imaging; Nitroimidazoles; Positron-Emission Tomography; Prognosis; Proportional Hazards Models; Radiopharmaceuticals; Tomography, X-Ray Computed

2015
Multiparametric imaging of patient and tumour heterogeneity in non-small-cell lung cancer: quantification of tumour hypoxia, metabolism and perfusion.
    European journal of nuclear medicine and molecular imaging, 2016, Volume: 43, Issue:2

    Topics: Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Female; Fluorodeoxyglucose F18; Humans; Lung Neoplasms; Male; Multimodal Imaging; Nitroimidazoles; Oxygen; Oxygen Consumption; Positron-Emission Tomography; Radiopharmaceuticals; Tomography, X-Ray Computed; Triazoles

2016
Comparison of hypoxia-activated prodrug evofosfamide (TH-302) and ifosfamide in preclinical non-small cell lung cancer models.
    Cancer biology & therapy, 2016, 04-02, Volume: 17, Issue:4

    Topics: Animals; Carcinoma, Non-Small-Cell Lung; Humans; Ifosfamide; Lung Neoplasms; Mice; Nitroimidazoles; Phosphoramide Mustards; Prodrugs; Xenograft Model Antitumor Assays

2016
A Comparative Study of Noninvasive Hypoxia Imaging with 18F-Fluoroerythronitroimidazole and 18F-Fluoromisonidazole PET/CT in Patients with Lung Cancer.
    PloS one, 2016, Volume: 11, Issue:6

    Topics: Adult; Aged; Demography; Female; Humans; Hypoxia; Lung Neoplasms; Male; Middle Aged; Misonidazole; Nitroimidazoles; Positron Emission Tomography Computed Tomography; Tissue Distribution

2016
Initial results of hypoxia imaging using 1-alpha-D: -(5-deoxy-5-[18F]-fluoroarabinofuranosyl)-2-nitroimidazole ( 18F-FAZA).
    European journal of nuclear medicine and molecular imaging, 2009, Volume: 36, Issue:10

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Female; Fluorine Radioisotopes; Glioma; Head and Neck Neoplasms; Humans; Hypoxia; Lung Neoplasms; Lymphoma; Male; Middle Aged; Neoplasms; Nitroimidazoles; Positron-Emission Tomography; Radiopharmaceuticals; Young Adult

2009
Misonidazole neuropathy.
    Acta neurologica Scandinavica. Supplementum, 1984, Volume: 100

    Topics: Aged; Female; Humans; Laryngeal Neoplasms; Lung Neoplasms; Male; Middle Aged; Misonidazole; Nitroimidazoles; Peripheral Nerves; Peripheral Nervous System Diseases; Pharyngeal Neoplasms

1984
Misonidazole combined with radiotherapy in the treatment of inoperable squamous cell carcinoma of the lung. A double-blind randomized trial.
    Cancer, 1983, Jul-01, Volume: 52, Issue:1

    Topics: Aged; Carcinoma, Squamous Cell; Double-Blind Method; Esophagitis; Humans; Lung Neoplasms; Misonidazole; Nitroimidazoles; Peripheral Nervous System Diseases; Placebos; Pneumonia; Radiation Injuries; Radiotherapy Dosage; Random Allocation; Vomiting

1983
[Clinical trials of hypoxic cell sensitizer misonidazole].
    Gan no rinsho. Japan journal of cancer clinics, 1983, Volume: 29, Issue:6

    Topics: Brain Neoplasms; Clinical Trials as Topic; Drug Evaluation; Female; Glioma; Head and Neck Neoplasms; Humans; Lung Neoplasms; Male; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Random Allocation; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms

1983
[Biological and physical approach to the improvement of radiotherapy].
    Gan no rinsho. Japan journal of cancer clinics, 1983, Volume: 29, Issue:13

    Topics: Animals; Cell Survival; Hot Temperature; Humans; Lung Neoplasms; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Radiotherapy

1983
[Clinical evaluation of hypoxic cell sensitizer (Misonidazole)].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:6

    Topics: Aged; Esophageal Neoplasms; Female; Humans; Kidney; Lung Neoplasms; Male; Middle Aged; Misonidazole; Nitroimidazoles; Oxygen; Stomach Neoplasms; Tongue Neoplasms; Uterine Cervical Neoplasms

1984
Misonidazole and radiotherapy in lung cancer: a randomized double-blind trial.
    International journal of radiation oncology, biology, physics, 1982, Volume: 8, Issue:10

    Topics: Aged; Carcinoma, Bronchogenic; Clinical Trials as Topic; Double-Blind Method; Humans; Lung Neoplasms; Male; Middle Aged; Misonidazole; Nitroimidazoles; Random Allocation

1982
Clinical testing of the radiosensitiser Ro-07-0582. III. Response of tumours.
    Clinical radiology, 1976, Volume: 27, Issue:2

    Topics: Adult; Cell Survival; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Lung Neoplasms; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Nitroimidazoles; Radiation-Sensitizing Agents; Radiotherapy Dosage; Skin Neoplasms; Soft Tissue Neoplasms

1976
Kinetic uptake of etanidazole in lung carcinoma and normal tissue in vivo.
    International journal of radiation oncology, biology, physics, 1992, Volume: 22, Issue:3

    Topics: Aged; Carcinoma, Bronchogenic; Combined Modality Therapy; Etanidazole; Female; Humans; Lung Neoplasms; Male; Middle Aged; Nitroimidazoles; Radiation-Sensitizing Agents; Reference Values

1992

Other Studies

65 other study(ies) available for azomycin and Lung Neoplasms

ArticleYear
Discovery of novel hypoxia-activated, nitroimidazole constructed multi-target kinase inhibitors on the basis of AZD9291 for the treatment of human lung cancer.
    Bioorganic & medicinal chemistry, 2023, 08-15, Volume: 91

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; ErbB Receptors; Humans; Hypoxia; Lung Neoplasms; Nitroimidazoles; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Structure-Activity Relationship

2023
Effects of Photodynamic Therapy with Redaporfin on Tumor Oxygenation and Blood Flow in a Lung Cancer Mouse Model.
    Scientific reports, 2019, 09-02, Volume: 9, Issue:1

    Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Kaplan-Meier Estimate; Lung Neoplasms; Mice, Inbred C57BL; Nitroimidazoles; Oxygen; Perfusion; Photochemotherapy; Porphyrins; Sulfonamides; Tissue Distribution; Tumor Hypoxia; Vascular Endothelial Growth Factor A

2019
Evolution of [
    Acta oncologica (Stockholm, Sweden), 2017, Volume: 56, Issue:4

    Topics: Aged; Female; Fluorodeoxyglucose F18; Humans; Image Interpretation, Computer-Assisted; Lung Neoplasms; Male; Middle Aged; Nitroimidazoles; Positron Emission Tomography Computed Tomography; Radiopharmaceuticals; Radiotherapy; Radiotherapy Dosage

2017
Concomitant Lung Cancer and Gastrointestinal Stromal Tumor: First Report of Hypoxia Imaging With 18F-FAZA PET/CT.
    Clinical nuclear medicine, 2017, Volume: 42, Issue:7

    Topics: Aged; Gastrointestinal Stromal Tumors; Humans; Lung Neoplasms; Male; Nitroimidazoles; Positron Emission Tomography Computed Tomography; Tumor Hypoxia

2017
Correlation analysis of [
    Acta oncologica (Stockholm, Sweden), 2017, Volume: 56, Issue:9

    Topics: Adenocarcinoma; Aged; Carcinoma, Squamous Cell; Female; Fluorodeoxyglucose F18; Humans; Lung Neoplasms; Male; Middle Aged; Nitroimidazoles; Positron Emission Tomography Computed Tomography; Prognosis; Radiopharmaceuticals; Radiotherapy Dosage; Radiotherapy Planning, Computer-Assisted; Small Cell Lung Carcinoma

2017
18F-FAZA PET/CT in the Preoperative Evaluation of NSCLC: Comparison with 18F-FDG and Immunohistochemistry.
    Current radiopharmaceuticals, 2018, Volume: 11, Issue:1

    Topics: Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Female; Fluorodeoxyglucose F18; Humans; Immunohistochemistry; Lung Neoplasms; Male; Middle Aged; Nitroimidazoles; Positron Emission Tomography Computed Tomography; Preoperative Care; Prospective Studies; Radiopharmaceuticals

2018
Raman spectroscopy detects metabolic signatures of radiation response and hypoxic fluctuations in non-small cell lung cancer.
    BMC cancer, 2019, May-20, Volume: 19, Issue:1

    Topics: Animals; Antigens, Neoplasm; Carbonic Anhydrase IX; Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Glycogen; Histones; Humans; Lung Neoplasms; Mice; Mice, Inbred NOD; Neoplasm Transplantation; Nitroimidazoles; Radiation Dosage; Spectrum Analysis, Raman; Treatment Outcome

2019
Pharmacokinetic analysis of [18F]FAZA in non-small cell lung cancer patients.
    European journal of nuclear medicine and molecular imaging, 2013, Volume: 40, Issue:10

    Topics: Aged; Carcinoma, Non-Small-Cell Lung; Female; Humans; Kinetics; Lung Neoplasms; Male; Middle Aged; Models, Biological; Nitroimidazoles; Positron-Emission Tomography; Radiopharmaceuticals

2013
PET imaging of tumor hypoxia using 18F-fluoroazomycin arabinoside in stage III-IV non-small cell lung cancer patients.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2013, Volume: 54, Issue:8

    Topics: Adult; Aged; Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Female; Fluorodeoxyglucose F18; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Nitroimidazoles; Positron-Emission Tomography; Tumor Burden

2013
Synthesis and evaluation of a new 99mTc(I)-tricarbonyl complex bearing the 5-nitroimidazol-1-yl moiety as potential hypoxia imaging agent.
    Journal of labelled compounds & radiopharmaceuticals, 2014, May-30, Volume: 57, Issue:6

    Topics: Animals; Biological Transport; Blood Proteins; Cell Hypoxia; Cell Line, Tumor; Chemical Phenomena; Chemistry Techniques, Synthetic; Drug Stability; Female; Hydrophobic and Hydrophilic Interactions; Ligands; Lung Neoplasms; Mice; Molecular Imaging; Nitroimidazoles; Organotechnetium Compounds; Radiopharmaceuticals; Tissue Distribution

2014
Parametric methods for quantification of 18F-FAZA kinetics in non-small cell lung cancer patients.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2014, Volume: 55, Issue:11

    Topics: Adult; Aged; Carcinoma, Non-Small-Cell Lung; Female; Humans; Kinetics; Lung Neoplasms; Male; Middle Aged; Nitroimidazoles; Positron-Emission Tomography; Radiopharmaceuticals; Regression Analysis; Reproducibility of Results; Time Factors; Tomography, X-Ray Computed; Treatment Outcome

2014
Dynamics of tumor hypoxia assessed by 18F-FAZA PET/CT in head and neck and lung cancer patients during chemoradiation: possible implications for radiotherapy treatment planning strategies.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2014, Volume: 113, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell Hypoxia; Chemoradiotherapy; Cohort Studies; Female; Head and Neck Neoplasms; Humans; Lung Neoplasms; Male; Middle Aged; Multimodal Imaging; Nitroimidazoles; Positron-Emission Tomography; Prospective Studies; Radiopharmaceuticals; Radiotherapy Planning, Computer-Assisted; Squamous Cell Carcinoma of Head and Neck; Tomography, X-Ray Computed

2014
The reverse Warburg effect and 18F-FDG uptake in non-small cell lung cancer A549 in mice: a pilot study.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2015, Volume: 56, Issue:4

    Topics: Animals; Blood Glucose; Body Weight; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Diet; Female; Fluorodeoxyglucose F18; Glucose; Humans; Hypoxia; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Nitroimidazoles; Pilot Projects; Positron-Emission Tomography; Radiopharmaceuticals; Tumor Microenvironment

2015
TH-302 in Combination with Radiotherapy Enhances the Therapeutic Outcome and Is Associated with Pretreatment [18F]HX4 Hypoxia PET Imaging.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2015, Jul-01, Volume: 21, Issue:13

    Topics: Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Chemoradiotherapy; Imidazoles; Lung Neoplasms; Nitroimidazoles; Phosphoramide Mustards; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Treatment Outcome; Triazoles; Xenograft Model Antitumor Assays

2015
Multiparametric Analysis of the Relationship Between Tumor Hypoxia and Perfusion with ¹⁸F-Fluoroazomycin Arabinoside and ¹⁵O-H₂O PET.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2016, Volume: 57, Issue:4

    Topics: Aged; Carcinoma, Non-Small-Cell Lung; Cluster Analysis; Female; Humans; Hypoxia; Lung Neoplasms; Male; Middle Aged; Neoplasms; Nitroimidazoles; Oxygen Radioisotopes; Positron-Emission Tomography; Radiopharmaceuticals; Regional Blood Flow; Water

2016
Prognostic significance of hypoxic PET using (18)F-FAZA and (62)Cu-ATSM in non-small-cell lung cancer.
    Lung cancer (Amsterdam, Netherlands), 2016, Volume: 91

    Topics: Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Coordination Complexes; Drug Resistance, Neoplasm; Female; Fluorodeoxyglucose F18; Humans; Lung Neoplasms; Male; Middle Aged; Nitroimidazoles; Organometallic Compounds; Positron-Emission Tomography; Prognosis; Radiopharmaceuticals; Retrospective Studies; Survival Analysis; Thiosemicarbazones

2016
Synthesis and radiolabeling of (64)Cu-labeled 2-nitroimidazole derivative (64)Cu-BMS2P2 for hypoxia imaging.
    Bioorganic & medicinal chemistry letters, 2016, Mar-01, Volume: 26, Issue:5

    Topics: Animals; Cell Hypoxia; Coordination Complexes; Copper Radioisotopes; Isotope Labeling; Lung Neoplasms; Mice; Molecular Imaging; Molecular Structure; Neoplasms, Experimental; Nitroimidazoles; Positron-Emission Tomography; Radiopharmaceuticals

2016
Preparation of alkyne-labeled 2-nitroimidazoles for identification of tumor hypoxia by Raman spectroscopy.
    Bioorganic & medicinal chemistry letters, 2016, 10-15, Volume: 26, Issue:20

    Topics: A549 Cells; Alkynes; Cell Hypoxia; Humans; Lung Neoplasms; Molecular Probes; Nitroimidazoles; Spectrum Analysis, Raman

2016
Synthesis and Biological Evaluation of a New Nitroimidazole-99mTc-Complex for Imaging of Hypoxia in Mice Model.
    Medical science monitor : international medical journal of experimental and clinical research, 2016, Oct-18, Volume: 22

    Topics: A549 Cells; Animals; Biological Availability; Cell Hypoxia; Cell Line, Tumor; Disease Models, Animal; Humans; Imino Acids; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Nitroimidazoles; Organotechnetium Compounds; Radiopharmaceuticals

2016
The hypoxia-selective cytotoxin NLCQ-1 (NSC 709257) controls metastatic disease when used as an adjuvant to radiotherapy.
    British journal of cancer, 2010, Jul-13, Volume: 103, Issue:2

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Hypoxia; Cell Line, Tumor; Chemotherapy, Adjuvant; Combined Modality Therapy; Drug Administration Schedule; Drug Evaluation, Preclinical; Imidazoles; Lung Neoplasms; Mice; Mice, Inbred C3H; Neoplasm Metastasis; Nitroimidazoles; Quinolines; Sarcoma; Tirapazamine; Triazines

2010
Irradiation-dependent effects on tumor perfusion and endogenous and exogenous hypoxia markers in an A549 xenograft model.
    International journal of radiation oncology, biology, physics, 2010, Aug-01, Volume: 77, Issue:5

    Topics: Adenocarcinoma; Animals; Apoptosis; Benzimidazoles; Biomarkers; Caspase 3; Cell Hypoxia; Contrast Media; Gadolinium; Glucose Transporter Type 1; Humans; Lung Neoplasms; Magnetic Resonance Imaging; Male; Mice; Mice, Nude; Microscopy, Fluorescence; Nitroimidazoles; Platelet Endothelial Cell Adhesion Molecule-1; Time Factors; Transplantation, Heterologous

2010
[Value of 18F-FETNIM PET-CT for detection of tumor hypoxia in non-small-cell lung cancer].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2010, Volume: 32, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Female; Humans; Lung Neoplasms; Male; Middle Aged; Nitroimidazoles; Positron-Emission Tomography; Tomography, X-Ray Computed

2010
Comparison of 18F-Fluoroerythronitroimidazole and 18F-fluorodeoxyglucose positron emission tomography and prognostic value in locally advanced non-small-cell lung cancer.
    Clinical lung cancer, 2010, Sep-01, Volume: 11, Issue:5

    Topics: Aged; Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Female; Fluorodeoxyglucose F18; Glucose; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Male; Middle Aged; Nitroimidazoles; Pilot Projects; Positron-Emission Tomography; Predictive Value of Tests; Prognosis; Radiopharmaceuticals

2010
Hypoxia in models of lung cancer: implications for targeted therapeutics.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2010, Oct-01, Volume: 16, Issue:19

    Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Electrodes; Histones; Humans; Lung Neoplasms; Male; Mice; Mice, Nude; Neoplasms, Experimental; Nitrogen Mustard Compounds; Nitroimidazoles; Oxygen; Positron-Emission Tomography; Proto-Oncogene Proteins c-myc; ras Proteins

2010
Dynamic contrast-enhanced magnetic resonance imaging of the metastatic potential of melanoma xenografts.
    International journal of radiation oncology, biology, physics, 2012, May-01, Volume: 83, Issue:1

    Topics: Animals; Biomarkers, Tumor; Cell Hypoxia; Contrast Media; Female; Gadolinium DTPA; Humans; Lung; Lung Neoplasms; Magnetic Resonance Imaging; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Nitroimidazoles; Transplantation, Heterologous; Tumor Microenvironment

2012
Operable non-small cell lung cancer: correlation of volumetric helical dynamic contrast-enhanced CT parameters with immunohistochemical markers of tumor hypoxia.
    Radiology, 2012, Volume: 264, Issue:2

    Topics: Aged; Biomarkers, Tumor; Blood Volume; Carcinoma, Non-Small-Cell Lung; Contrast Media; Female; Humans; Hypoxia; Immunohistochemistry; Iohexol; Lung Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Grading; Neoplasm Staging; Nitroimidazoles; Prospective Studies; Radiation-Sensitizing Agents; Radiographic Image Interpretation, Computer-Assisted; Statistics, Nonparametric; Tomography, Spiral Computed

2012
Tumor microenvironment-dependent 18F-FDG, 18F-fluorothymidine, and 18F-misonidazole uptake: a pilot study in mouse models of human non-small cell lung cancer.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2012, Volume: 53, Issue:8

    Topics: Animals; Biological Transport; Bromodeoxyuridine; Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Dideoxynucleosides; Disease Models, Animal; Female; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Humans; Lung Neoplasms; Mice; Misonidazole; Necrosis; Nitroimidazoles; Pilot Projects; Positron-Emission Tomography; Radioactive Tracers; Tumor Microenvironment

2012
A novel hypoxia-dependent 2-nitroimidazole KIN-841 inhibits tumour-specific angiogenesis by blocking production of angiogenic factors.
    British journal of cancer, 2003, Jan-27, Volume: 88, Issue:2

    Topics: Angiogenesis Inhibitors; Animals; Carcinoma, Lewis Lung; Cattle; Cell Division; Chick Embryo; Chorion; Endothelial Growth Factors; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Hydroxamic Acids; Hypoxia; Imidazoles; Injections, Intraperitoneal; Intercellular Signaling Peptides and Proteins; Lung Neoplasms; Lymphokines; Mice; Neovascularization, Pathologic; Nitro Compounds; Nitroimidazoles; Pulmonary Artery; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2003
Tumor hypoxia correlates with metastatic tumor growth of pancreatic cancer in an orthotopic murine model.
    The Journal of surgical research, 2004, Volume: 120, Issue:2

    Topics: Abdominal Neoplasms; Animals; Cell Hypoxia; Cell Line, Tumor; Disease Progression; Humans; Lung Neoplasms; Male; Mice; Mice, Nude; Neoplasm Invasiveness; Nitroimidazoles; Oxygen; Pancreatic Neoplasms; Partial Pressure; Staining and Labeling

2004
Modulation of intratumoral hypoxia by the epidermal growth factor receptor inhibitor gefitinib detected using small animal PET imaging.
    Molecular cancer therapeutics, 2005, Volume: 4, Issue:9

    Topics: Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; ErbB Receptors; Fluorine Radioisotopes; Gefitinib; Humans; Hypoxia; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Nitroimidazoles; Oxidation-Reduction; Oxygen; Positron-Emission Tomography; Quinazolines; Tissue Distribution

2005
Initial evaluation of dynamic human imaging using 18F-FRP170 as a new PET tracer for imaging hypoxia.
    Annals of nuclear medicine, 2007, Volume: 21, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Female; Humans; Lung Neoplasms; Male; Middle Aged; Nitroimidazoles; Organ Specificity; Pilot Projects; Positron-Emission Tomography; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Tissue Distribution; Whole Body Imaging

2007
Tumor hypoxia imaging with [F-18] fluoronitroimidazole in non-small-cell lung cancer.
    Journal of the American Geriatrics Society, 2007, Volume: 55, Issue:7

    Topics: Aged; Carcinoma, Non-Small-Cell Lung; Diagnosis, Differential; Female; Humans; Hypoxia; Lung Neoplasms; Male; Nitroimidazoles; Reproducibility of Results; Retrospective Studies; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed

2007
Misonidazole & radiotherapy in the palliative treatment of lung cancer.
    Australasian radiology, 1983, Volume: 27, Issue:3

    Topics: Administration, Oral; Aged; Carcinoma, Bronchogenic; Drug Evaluation; Female; Humans; Lung; Lung Neoplasms; Male; Middle Aged; Misonidazole; Nitroimidazoles; Palliative Care

1983
Studies on the protection against misonidazole-induced toxicity by antiinflammatory agents.
    Advances in prostaglandin, thromboxane, and leukotriene research, 1983, Volume: 12

    Topics: Animals; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dexamethasone; Female; Flurbiprofen; Lung; Lung Neoplasms; Mice; Mice, Inbred Strains; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Phospholipases; Phospholipases A; Propionates

1983
Reduced fractionation and the potential of hypoxic cell sensitizers in irradiation of malignant epithelial tumors.
    International journal of radiation oncology, biology, physics, 1980, Volume: 6, Issue:1

    Topics: Adenocarcinoma; Carcinoma; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Humans; Lung Neoplasms; Misonidazole; Mouth Neoplasms; Nitroimidazoles; Oropharynx; Pharyngeal Neoplasms; Radiation-Sensitizing Agents; Radiotherapy Dosage; Retrospective Studies

1980
Effect of tumor size on S-2-(3-aminopropylamino)ethylphosphorothioic acid and misonidazole alteration of tumor response to cyclophosphamide.
    Cancer research, 1983, Volume: 43, Issue:7

    Topics: Amifostine; Animals; Cyclophosphamide; Drug Interactions; Drug Therapy, Combination; Extremities; Female; Fibrosarcoma; Lung Neoplasms; Male; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Organothiophosphorus Compounds; Time Factors

1983
Intestinal microflora as potential modifiers of sensitizer activity in vivo.
    International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:8

    Topics: Animals; Bacteria; Body Temperature; Combined Modality Therapy; Drug Synergism; Female; Intestines; Lung Neoplasms; Melphalan; Mice; Misonidazole; Nitroimidazoles; Penicillins; Radiation-Sensitizing Agents

1984
Enhancement of artificial lung metastases by misonidazole.
    International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:8

    Topics: Animals; Cell Line; Female; Lung Neoplasms; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents

1984
Potentiation of cyclophosphamide cytotoxicity in vivo: a study with misonidazole and fifteen other 1-substituted 2-nitroimidazoles.
    International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:9

    Topics: Animals; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Female; Lung Neoplasms; Melanoma; Mice; Mice, Inbred C57BL; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents; Time Factors

1984
Clinical trials with cyclophosphamide and misonidazole combination for maintaining treatment after radiation therapy of lung carcinoma.
    International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:9

    Topics: Adult; Aged; Combined Modality Therapy; Cyclophosphamide; Drug Synergism; Drug Therapy, Combination; Female; Humans; Lung Neoplasms; Male; Middle Aged; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents

1984
[Clinical evaluation of radiosensitizing effects of misonidazole].
    Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica, 1984, Jul-25, Volume: 44, Issue:7

    Topics: Brain Neoplasms; Combined Modality Therapy; Drug Evaluation; Esophageal Neoplasms; Humans; Lung Neoplasms; Misonidazole; Nitroimidazoles

1984
[Radiotherapy in combination with misonidazole and ACNU in lung neoplasms].
    Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica, 1983, Nov-25, Volume: 43, Issue:11

    Topics: Adult; Aged; Antineoplastic Agents; Combined Modality Therapy; Female; Humans; Lung Neoplasms; Male; Middle Aged; Misonidazole; Nimustine; Nitroimidazoles; Nitrosourea Compounds; Radiotherapy Dosage

1983
Radiosensitization in vivo: a study with an homologous series of 2-nitroimidazoles.
    International journal of radiation biology and related studies in physics, chemistry, and medicine, 1983, Volume: 44, Issue:4

    Topics: Animals; Carcinoma; Cell Survival; Cells, Cultured; Drug Evaluation, Preclinical; Lung Neoplasms; Mice; Mice, Inbred C57BL; Nitroimidazoles; Radiation-Sensitizing Agents; Structure-Activity Relationship; Time Factors

1983
The role of dexamethasone in the modification of misonidazole pharmacokinetics.
    British journal of cancer, 1983, Volume: 48, Issue:4

    Topics: Adult; Aged; Dexamethasone; Drug Interactions; Female; Humans; Kinetics; Lung Neoplasms; Male; Metabolic Clearance Rate; Middle Aged; Misonidazole; Nitroimidazoles; Phenobarbital; Phenytoin

1983
[Clinical study on radiotherapy in combination with misonidazole].
    Nihon Gan Chiryo Gakkai shi, 1983, Aug-20, Volume: 18, Issue:5

    Topics: Aged; Esophageal Neoplasms; Female; Humans; Lung Neoplasms; Middle Aged; Misonidazole; Neoplasms; Nitroimidazoles; Pharyngeal Neoplasms; Radiation-Sensitizing Agents

1983
Large fraction radiotherapy plus misonidazole for treatment of advanced lung cancer: report of a phase I/II trial.
    International journal of radiation oncology, biology, physics, 1982, Volume: 8, Issue:2

    Topics: Adenocarcinoma; Adult; Aged; Carcinoma, Squamous Cell; Drug Evaluation; Female; Humans; Lung Neoplasms; Male; Middle Aged; Misonidazole; Nitroimidazoles; Radiotherapy; Radiotherapy Dosage

1982
Misonidazole Neuropathy: a clinical, electrophysiological, and histological study.
    Annals of neurology, 1982, Volume: 12, Issue:1

    Topics: Aged; Carcinoma, Squamous Cell; Electromyography; Female; Humans; Laryngeal Neoplasms; Lung Neoplasms; Male; Median Nerve; Middle Aged; Misonidazole; Nerve Fibers, Myelinated; Nervous System Diseases; Neural Conduction; Neuromuscular Diseases; Nitroimidazoles; Paresthesia; Peroneal Nerve; Pharyngeal Neoplasms; Sensation; Sural Nerve; Tibial Nerve

1982
Combinations of radiation and misonidazole in a murine lung tumor model.
    Radiation research, 1981, Volume: 86, Issue:2

    Topics: Animals; Cell Survival; Dose-Response Relationship, Radiation; Female; Lung; Lung Neoplasms; Mice; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Radiotherapy; Sarcoma, Experimental; Time Factors

1981
Enhanced cell killing in lewis lung carcinoma and a human pancreatic-carcinoma xenograft by the combination of cytotoxic drugs and misonidazole.
    British journal of cancer, 1981, Volume: 43, Issue:4

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Survival; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Lung Neoplasms; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Pancreatic Neoplasms; Transplantation, Heterologous

1981
Cytotoxic and radiosensitizing effects of misonidazole on hematopoiesis in normal and tumor-bearing mice.
    International journal of radiation oncology, biology, physics, 1980, Volume: 6, Issue:9

    Topics: Animals; Colony-Forming Units Assay; Dose-Response Relationship, Radiation; Hematopoiesis; Hematopoietic Stem Cells; Hypoxia; Lung Neoplasms; Male; Mice; Misonidazole; Neoplasms, Experimental; Nitroimidazoles

1980
Imaging tumor hypoxia and tumor perfusion.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1993, Volume: 34, Issue:6

    Topics: Brain Neoplasms; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Cell Hypoxia; Female; Glioblastoma; Head and Neck Neoplasms; Humans; Iodine Radioisotopes; Lung Neoplasms; Male; Nitroimidazoles; Organotechnetium Compounds; Oximes; Sarcoma; Soft Tissue Neoplasms; Technetium Tc 99m Exametazime; Tomography, Emission-Computed, Single-Photon

1993
Development of new markers for hypoxic cells: [131I]Iodomisonidazole and [131I]Iodoerythronitroimidazole.
    Journal of drug targeting, 1996, Volume: 4, Issue:1

    Topics: Animals; Breast Neoplasms; Cell Hypoxia; Female; Iodine Radioisotopes; Lung Neoplasms; Mice; Mice, Inbred BALB C; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents; Radionuclide Imaging; Rats; Rats, Inbred F344; Tissue Distribution; Tumor Cells, Cultured

1996
TX-1877: design, synthesis, and biological activities as a BRM-functional hypoxic cell radiosensitizer.
    International journal of radiation oncology, biology, physics, 1998, Nov-01, Volume: 42, Issue:4

    Topics: Animals; Cell Hypoxia; Drug Design; Female; Immunologic Factors; Lung Neoplasms; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents

1998
Lung metastasis suppression of the bifunctional new radiosensitizer KIN-806.
    International journal of molecular medicine, 1999, Volume: 4, Issue:3

    Topics: Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Female; Gamma Rays; Lung Neoplasms; Mice; Mice, Inbred Strains; Molecular Structure; Nitroimidazoles; Radiation-Sensitizing Agents; Tumor Cells, Cultured

1999
New antimetastatic hypoxic cell radiosensitizers: design, synthesis, and biological activities of 2-nitroimidazole-acetamide, TX-1877, and its analogues.
    Bioorganic & medicinal chemistry, 2001, Volume: 9, Issue:2

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Movement; Drug Design; Electrochemistry; Female; Hypoxia; Leukocytes, Mononuclear; Lung Neoplasms; Macrophages; Mice; Mice, Inbred C3H; Models, Molecular; Neoplasm Metastasis; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents; Structure-Activity Relationship; Tumor Cells, Cultured

2001
[The use of potentiating agents in megavoltage therapy of non-resected localized carcinoma of the lung (author's transl)].
    Revue francaise des maladies respiratoires, 1979, Volume: 7, Issue:7

    Topics: Carcinoma, Squamous Cell; Dose-Response Relationship, Radiation; Hot Temperature; Humans; Lung Neoplasms; Neutrons; Nitroimidazoles; Radiotherapy, High-Energy

1979
Influence of tumour size on radiosensitization by misonidazole.
    The British journal of cancer. Supplement, 1978, Volume: 3

    Topics: Animals; Cell Survival; Lung Neoplasms; Melanoma; Mice; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents

1978
The response of human tumour metastases to radiation and misonidazole.
    The British journal of cancer. Supplement, 1978, Volume: 3

    Topics: Humans; Lung Neoplasms; Male; Neoplasm Metastasis; Nitroimidazoles; Radiation-Sensitizing Agents; Skin Neoplasms

1978
Distribution and tumour cytotoxicity of the radiosensitizer misonidazole (Ro-07-0582) in C57 mice.
    British journal of cancer, 1979, Volume: 39, Issue:4

    Topics: Animals; Cell Survival; Guinea Pigs; Lung Neoplasms; Mice; Mice, Inbred C57BL; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Tissue Distribution

1979
The quantitative response of human tumours to radiation and misonidazole.
    British journal of cancer, 1979, Volume: 40, Issue:6

    Topics: Adolescent; Adult; Aged; Dose-Response Relationship, Radiation; Female; Humans; Lung Neoplasms; Male; Middle Aged; Misonidazole; Nitroimidazoles; Skin Neoplasms

1979
Non-invasive assessment of human tumour hypoxia with 123I-iodoazomycin arabinoside: preliminary report of a clinical study.
    British journal of cancer, 1992, Volume: 65, Issue:1

    Topics: Adult; Aged; Carcinoma, Small Cell; Female; Half-Life; Humans; Hypoxia; Iodine Radioisotopes; Lung Neoplasms; Male; Middle Aged; Neoplasms; Nitroimidazoles; Tomography, Emission-Computed

1992
Lack of stereoselectivity in the pharmacokinetics and metabolism of the radiosensitizer Ro 03-8799 in man.
    Cancer chemotherapy and pharmacology, 1991, Volume: 28, Issue:2

    Topics: Adenocarcinoma; Aged; Carcinoma, Squamous Cell; Female; Humans; Lung Neoplasms; Male; Middle Aged; Nitroimidazoles; Radiation-Sensitizing Agents; Stereoisomerism

1991
Pharmacokinetics of Ro 03-8799 in mice bearing melanosarcoma: comparison with tumors without melanin.
    International journal of radiation oncology, biology, physics, 1989, Volume: 16, Issue:4

    Topics: Animals; Lung Neoplasms; Melanins; Melanoma, Experimental; Mice; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents

1989
Influence of misonidazole, SR-2508, RSU-1069 and WR-2721 on spontaneous metastases in C57BL mice.
    International journal of radiation oncology, biology, physics, 1988, Volume: 14, Issue:2

    Topics: Amifostine; Animals; Etanidazole; Lung Neoplasms; Male; Melanoma; Mice; Mice, Inbred C57BL; Misonidazole; Neoplasm Metastasis; Neoplasms, Experimental; Nitroimidazoles; Radiation-Protective Agents; Radiation-Sensitizing Agents

1988
[Present status of hypoxic cell sensitizers and PLDR inhibitors].
    Gan no rinsho. Japan journal of cancer clinics, 1987, Volume: 33, Issue:13

    Topics: Animals; Cell Cycle; Cell Line; Etanidazole; Humans; Lung Neoplasms; Misonidazole; Nitroimidazoles; Radiation Tolerance; Radiation-Protective Agents; Radiation-Sensitizing Agents; Radiotherapy Dosage

1987