azomycin has been researched along with Disease Models, Animal in 184 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (3.80) | 18.7374 |
| 1990's | 6 (3.26) | 18.2507 |
| 2000's | 36 (19.57) | 29.6817 |
| 2010's | 113 (61.41) | 24.3611 |
| 2020's | 22 (11.96) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Beiki, D; Binns, D; Cullinane, C; Ehrlichmann, W; Hicks, R; Kumar, P; Machulla, HJ; Naimi, E; Reischl, G; Roselt, P; Wiebe, LI; Yang, J | 1 |
| Barbosa, C; Carrillo, I; Castillo, C; Díaz-Araya, G; Fuentes-Retamal, S; González-Herrera, F; Guzmán-Rivera, D; Kemmerling, U; Machado, FS; Maya, JD; Quintero, H; Rabelo, RAN; Rates, M | 1 |
| Cevey, ÁC; Goren, NB; Mascolo, PD; Mirkin, GA; Penas, FN; Pieralisi, AV; Sequeyra, AS | 1 |
| Brancaglion, GA; Caldas, IS; Caldas, S; Carvalho, DT; Diniz, LF; Gonçalves-Santos, E; Mazzeti, AL; Novaes, RD; Oliveira, RRG; Silva, LS; Vilas-Boas, DF | 1 |
| Barbosa, JMC; Cascabulho, CM; Daliry, A; de Melo, TG; de Oliveira, G; Pedra Rezende, Y; Pereira, ENGDS; Salem, KS | 1 |
| Carr, W; Converse, PJ; Dartois, V; Dooley, KE; Garcia, A; Kurbatova, E; Nuermberger, EL; Stout, JE; Tasneen, R; Vernon, AA; Zimmerman, MD | 1 |
| Ang, CW; Avery, VM; Bernhardt, PV; Blaskovich, MAT; Bolisetti, R; Cooper, MA; Francisco, AF; Franzblau, SG; Hinton, AO; Jackson, CJ; Kelly, JM; Lee, BM; Sykes, ML; Tan, L; Wang, Y; West, NP | 1 |
| Bahr, M; Brosnan, MK; Chen, X; Dannals, RF; De Jesus, P; Erice, C; Flavahan, K; Holt, DP; Jain, SK; Kim, J; Lodge, MA; Mota, F; Ordonez, AA; Peloquin, CA; Ruiz-Bedoya, CA; Tucker, EW | 1 |
| Almeida, IC; Begum, K; Cardenas-Ovando, RA; Fernández-Figueroa, EA; Iandra da Silva Ferreira, B; Lannes-Vieira, J; Moreira, OC; Pereira, IR; Roy, S; Silva Grijó Farani, P; Vilar-Pereira, G | 1 |
| Bua, J; Esteva, M; Fichera, LE; Pereira, CA; Prado, N; Reigada, C; Rial, MS | 1 |
| Branquinho, RT; de Assis, G; de Lana, M; de Oliveira, MT; Gonçalves, MF; Milagre, MM; Reis, L; Saúde-Guimarães, DA | 1 |
| Dąbrowski, JM; Elas, M; Gonet, M; Karwicka, M; Pucelik, B | 1 |
| Aviles, AS; Carneiro, CM; Cunha, LM; da Silva Fonseca, K; de Abreu Vieira, PM; Molina, I; Perin, L | 1 |
| Díaz, ML; Echeverría, LE; Eduardo Nieto, J; González, CI; Hernandez, JCM; López-Romero, LA; Morillo, CA; Ochoa, SAG; Rivera, JD; Rojas, LZ; Suárez, EU | 1 |
| Cascabulho, CM; Castro, SL; Demarque, KC; Duque, TLA; Guimarães, ACR; Manso, PPA; Menna-Barreto, RF; Meuser-Batista, M; Moura, KCG; Oliveira, GM; Pelajo-Machado, M; Pinto, MDC | 1 |
| Bermúdez, JM; Cid, AG; Davies, C; Micheloud, JF; Negrette, OS; Parada, LA; Ragone, PG; Simonazzi, A | 1 |
| Caldas, IS; Diniz, LF; Gonçalves, RV; Gonçalves-Santos, E; González-Lozano, KJ; Mendonça, AAS; Novaes, RD; Souza-Silva, TG | 1 |
| Calvet, CM; Hirata, K; McKerrow, JH; Silva, TA; Siqueira-Neto, JL; Suzuki, B; Thomas, D | 1 |
| Búa, J; Esteva, MI; Fichera, LE; Rial, MS; Salomon, CJ; Seremeta, KP | 1 |
| Cramer, RA; Grahl, N; Kowalski, CH | 1 |
| Bax, HI; de Steenwinkel, JEM; Keutzer, L; Pieterman, ED; Simonsson, USH; van den Berg, S; van der Meijden, A; Wang, H; Zimmerman, MD | 1 |
| Abdalah, MA; Budzevich, MM; Bui, MM; Dominguez-Viqueira, W; Gillies, RJ; Huang, S; Jardim-Perassi, BV; Johnson, JO; Martinez, GV; Mu, W; Poleszczuk, J; Reed, DR; Tomaszewski, MR | 1 |
| Engman, DM; Falk, BA; Li, X; Martinez, SJ; Olson, CL; Romano, PS; Scariot, DB; Scott, EA; Yi, S | 1 |
| Anderson, RF; Blaser, A; Chatelain, E; Denny, WA; Franzblau, SG; Launay, D; Ma, Z; Maes, L; Palmer, BD; Shinde, SS; Thompson, AM; Wan, B; Wang, Y | 1 |
| Alavijeh, MS; Burrell-Saward, H; Croft, SL; de LaFlor, R; Harris, AJ; Sallam, H; Ward, TH | 1 |
| Converse, PJ; Li, SY; Mdluli, K; Nuermberger, EL; Soni, H; Tasneen, R; Tyagi, S | 1 |
| Hart, CP; Kishimoto, S; Krishna, MC; Matsumoto, S; Mitchell, JB; Naz, S; Saito, K; Takakusagi, Y | 1 |
| Jayagopal, A; McCollum, GW; Penn, JS; Uddin, MI; Yang, R | 1 |
| Li, DG; Ren, ZX | 1 |
| Alland, D; Bajaj, A; Dhiman, R; Gosain, TP; Hwang, YK; Jung, MG; Kidwai, S; Kumar, P; Kumar, S; Lee, IY; Mawatwal, S; Park, CY; Singh, R; Song, CS; Tiwari, P | 1 |
| Carneiro, CM; Corrêa-Oliveira, R; Fonseca Murta, SM; Molina, I; Sales Junior, PA; Salvador, F; Sánchez-Montalvá, A | 1 |
| Campos, MC; Clark, TG; Francisco, AF; Kelly, JM; Lewis, MD; Pain, A; Phelan, J; Taylor, MC | 1 |
| Bacchi, CJ; Braillard, S; Chatelain, E; Denny, WA; Gaukel, E; Launay, D; Maes, L; Marshall, AJ; Mowbray, CE; Thompson, AM; Wring, SA; Yarlett, N | 1 |
| Arrúa, EC; Esteva, MI; Fichera, LE; Rial, MS; Salomon, CJ; Scalise, ML | 1 |
| Connell, N; Dartois, V; Freundlich, JS; Ho, HP; Inoyama, D; Kandasamy, S; Kumar, P; Occi, J; Paget, SD; Perryman, AL; Russo, R; Singleton, E; Tuckman, M; Zimmerman, MD | 1 |
| Bayin, NS; Placantonakis, DG | 1 |
| Altcheh, J; Bisio, M; García-Bournissen, F; Gulin, JEN; Rocco, DM; Solana, ME | 1 |
| Gendoo, DMA; Haibe-Kains, B; Haller, A; Haynes, J; Jaffray, DA; Kreso, A; Leung, C; Lima-Fernandes, E; McKee, TD; Metser, U; O'Brien, CA; Smith, M; Szentgyorgyi, E; Vines, DC; Wang, Y; Wolman, R; Wouters, BG | 1 |
| Bahia, MT; Caldas, IS; Diniz, LF; Mazzeti, AL; Ribeiro, I | 1 |
| Brocks, DR; Jans, HS; Kumar, P; Wiebe, LI; Wuest, M; Yang, XH | 1 |
| Aoki, MP; García, MC; Jimenez-Kairuz, AF; Manzo, RH; Martinelli, M; Ponce, NE; Sanmarco, LM | 1 |
| Batlle, A; Demaria, A; Frank, FM; Lombardo, ME; Puente, V | 1 |
| Bahia, MT; Caldas, IS; Caldas, S; Diniz, LF; Menezes, APJ; Nascimento, ÁFDSD; Novaes, RD | 1 |
| Chin, CM; da Rosa, JA; de Andrade, CR; Dos Santos, JL; Scarim, CB | 1 |
| Bezerra, FS; Costa, GP; Figueiredo, VP; Horta, AL; Leite, ALJ; Menezes, APJ; Pedrosa, TCF; Ramos, CO; Talvani, A; Vieira, PMA | 1 |
| Bastos, TM; Efstathiou, A; Gaboriaud-Kolar, N; Meira, CS; Rocha, VPC; Skaltsounis, AL; Smirlis, D; Soares, MBP; Vougogiannopoulou, K | 1 |
| Batista, DDGJ; Batista, MM; Britto, C; Da Silva, CF; Guedes-da-Silva, FH; Lepesheva, GI; Moreira, OC; Pavão, BP; Rachakonda, G; Soeiro, MNC; Souza, LRQ; Villalta, F | 1 |
| Cao, J; Hong, H; Kung, HF; Liu, Y; Qiao, J; Yao, X; Zha, Z; Zhang, A; Zhang, L; Zhang, Y; Zhao, R; Zhu, L | 1 |
| Aguiar, MMG; de Morais-Teixeira, E; Rabello, A | 1 |
| Gonçalves, RV; Maldonado, IRSC; Mendonça, AAS; Natali, AJ; Novaes, RD; Souza-Silva, TG; Talvani, A | 1 |
| Bolcaen, J; Boterberg, T; De Meulenaere, V; De Vos, F; Deblaere, K; Descamps, B; Donche, S; Goethals, I; Kalala, JP; Kersemans, K; Van den Broecke, C; Vanhove, C; Verhoeven, J | 1 |
| Evans, RG; Ngo, JP; Ow, CPC; Sayakkarage, A; Ullah, MM | 1 |
| Gonçalves, RV; Maldonado, IRSC; Natali, AJ; Novaes, RD; Santos, EC; Santos, EG; Souza-Silva, TG; Talvani, A | 1 |
| Baez, A; Bazán, PC; Cremonezzi, D; Esteves, B; Fauro, R; Lo Presti, MS; Paglini-Oliva, PA; Rivarola, HW; Sanchez Negrete, O; Strauss, M | 1 |
| Alarcon, ML; Bua, J; Fichera, LE; Grosso, NL; Laucella, SA; Riarte, A | 1 |
| Hansen-Schwartz, J; Hasseldam, H; Hou, J; Johansen, FF; Munkholm, N | 1 |
| Cunha, WR; da Silva Ferreira, D; de Albuquerque, S; do Prado Júnior, JC; e Silva, ML; Esperandim, VR; Kuehn, CC; Toldo, MP | 1 |
| Alsultan, A; Belchis, DA; Dutta, NK; Gniadek, TJ; Karakousis, PC; Mdluli, KE; Nuermberger, EL; Peloquin, CA; Pinn, ML | 1 |
| De Bruyne, E; De Bryune, E; De Raeve, H; Handisides, D; Hart, CP; Hu, J; Menu, E; Van Camp, B; Van Valckenborgh, E; Vanderkerken, K; Xu, D; Xu, S | 1 |
| Belloli, S; Brioschi, A; Calderoni, S; Fazio, F; Mauro, A; Monterisi, C; Moresco, RM; Pagani, A; Politi, LS; Raccagni, I; Ronchetti, F; Zara, G; Zenga, F | 1 |
| Bahia, MT; Caldas, IS; de Andrade, IM; Diniz, Lde F; Martins, TA; Mazzeti, AL; Ribeiro, I; Talvani, A; Urbina, JA | 1 |
| Bahia, MT; Caldas, IS; Daliry, A; de Carvalho, AC; de Figueiredo Diniz, L; Talvani, A; Torres, RM | 1 |
| Enjoji, M; Kato, M; Kotoh, K; Masaki, Y; Miyazaki, M; Nakamuta, M; Takayanagi, R; Tanaka, K; Tanaka, M | 1 |
| Branquinho, RT; de Lana, M; de Oliveira-Silva, JC; Mosqueira, VC; Saúde-Guimarães, DA; Simões-Silva, MR | 1 |
| Abdelkader, A; Eppel, GA; Evans, RG; Ho, J; Ow, CP; Rajapakse, NW; Schlaich, MP | 1 |
| Bahia, MT; Caldas, IS; Charman, SA; Chatelain, E; Diniz, Lde F; Gonçalves, KR; Koltun, M; Marques, LF; Mazzeti, AL; Mota, LW; Nascimento, AF; Saunders, J; Scandale, I; Shackleford, DM; Talvani, A; White, KL | 1 |
| Barry, CE; Blasco, F; Boshoff, HI; Cherian, J; Dick, T; Goh, A; Gurumurthy, M; Ho, PC; Jiricek, J; Lakshminarayana, SB; Manjunatha, UH; Nanjundappa, M; Nayyar, A; Ravindran, S; Singh, R | 1 |
| Dutta, NK; Karakousis, PC | 1 |
| Cho, S; Franzblau, SG; Kim, Y; Lu, Y; Ma, Z; Mdluli, K; Upton, AM; Wang, B; Wang, Y; Xu, J; Yang, TJ | 1 |
| Amoabeng, O; Mdluli, KE; Minkowski, A; Nuermberger, EL; Tasneen, R; Upton, AM; Williams, K | 1 |
| Gupta, S; Launay, D; Martin, D; Puri, SK; Sharma, B; Shivahare, R; Vishwakarma, P; Yardley, V | 1 |
| Bol, A; Bol, V; Gallez, B; Grégoire, V; Jordan, B; Karroum, O; Labar, D; Tran, LB | 1 |
| Bol, A; Cao-Pham, TT; Gallez, B; Grégoire, V; Jordan, B; Labar, D; Tran, LB | 1 |
| Araújo, MS; Carneiro, CM; Lana, Md; Machado-de-Assis, GF; Martins, HR; Martins-Filho, OA; Oliveira, MT; Oliveira-Silva, JC; Paiva, NC | 1 |
| Blaser, A; Denny, WA; Franzblau, SG; Kmentova, I; Ma, Z; Palmer, BD; Sutherland, HS; Thompson, AM; Wan, B; Wang, Y | 3 |
| Baeza, I; Meza-Toledo, S; Nogueda-Torres, B; Serna, M; Wong, C; Wong-Baeza, C | 1 |
| Araujo, AP; Giorgio, S | 1 |
| Chatelain, E; Francisco, AF; Jayawardhana, S; Kelly, JM; Lewis, MD; Taylor, MC | 1 |
| Assíria Fontes Martins, T; Bahia, MT; Caldas, IS; Caldas, S; da Silva do Nascimento, ÁF; de Andrade, IM; de Figueiredo Diniz, L; Mazzeti, AL; Ribeiro, I | 1 |
| Galoforo, S; Grills, IS; Kane, JL; Krueger, SA; Marples, B; Wilson, GD; Wobb, J | 1 |
| Alajarín, R; Álvarez-Builla, J; de Ceballos, ML; Delgado, M; García-García, L; Kelly, J; Lizasoain, I; Nieto, E; Pozo, MA; Sobrado, M | 1 |
| Glynne, R; Groessl, T; Khare, S; Liu, X; Molteni, V; Rivera, I; Stinson, M; Supek, F; Tuntland, T; Wen, B; Yeh, V | 1 |
| Cifuente, D; Lozano, E; Rivarola, HW; Sosa, MA; Spina, R; Strauss, M; Tonn, C | 1 |
| Batista, DG; Britto, C; da Silva, CF; de Araújo, JS; Ferreira, CG; Guedes-da-Silva, FH; Lepesheva, GI; Meuser, MB; Moreira, OC; Simões-Silva, MR; Soeiro, Mde N | 1 |
| Betoudji, F; Converse, PJ; Dartois, V; Li, SY; Mdluli, KE; Mendel, CM; Nuermberger, EL; Tasneen, R; Tyagi, S; Williams, K; Yang, T | 1 |
| Andreeff, M; Bankson, JA; Benito, J; Bhattacharya, PK; Cortes, JE; Davis, RE; Hart, CP; Harutyunyan, KG; Jacamo, R; Konoplev, S; Konopleva, M; Lee, J; Lu, H; Ma, H; Marszalek, JR; Matre, P; McQueen, T; Millward, NZ; Mu, H; Protopopova, M; Ramirez, MS; Shi, YX; Velez, J; Volgin, A | 1 |
| Bruhn, DF; Lee, RE; Lenaerts, AJ; Liu, J; Scherman, MS; Singh, AP; Yang, L | 1 |
| Araújo, JS; Bakunov, SA; Bakunova, SM; Batista, DG; Britto, C; Da Silva, CF; Da Silva, PB; Demarque, KC; Fulco, TO; Guedes-da-Silva, FH; Meuser, MB; Moreira, OC; Oliveira, GM; Patrick, DA; Soeiro, MN; Tidwell, RR | 1 |
| Cevey, ÁC; Goren, NB; Mirkin, GA; Penas, FN | 1 |
| Aoki, MP; García, MC; Jimenez-Kairuz, AF; Manzo, RH; Ponce, NE; Sanmarco, LM | 1 |
| Auer, JL; Fairlamb, AH; Norval, S; Osuna-Cabello, M; Patterson, S; Read, KD; Simeons, FR; Stojanovski, L; Wyllie, S | 1 |
| Chen, X; Duan, Y; Gao, R; Liang, M; Ou, Y; Wang, L; Wang, P; Wang, Z; Yuan, Y; Zhu, H; Zou, M | 1 |
| Fourcade, O; Geeraerts, T; Gonzalez, L; Kerhuel, L; Luzi, A; Mrozek, S | 1 |
| Branquinho, RT; de Mello, CG; Lana, Md; Milagre, MM; Mosqueira, VC; Oliveira, MT; Saúde-Guimarães, DA | 1 |
| Brayton, CF; Chapiro, J; Cornish, TC; Duran, R; Frangakis, C; Ganapathy-Kanniappan, S; Geschwind, JF; Gorodetski, B; Hart, CP; Lin, M; Mirpour, S; Pekurovsky, V; Reyes, J; Schernthaner, RE; Sun, JD | 1 |
| Barnes, SL; Kang, H; Quarles, CC; Sanchez, V; Sorace, AG; Syed, AK; Yankeelov, TE | 1 |
| Charman, SA; Chatelain, E; Chen, G; Francisco, AF; Jayawardhana, S; Kelly, JM; Lewis, MD; Osuna-Cabello, M; Read, KD; Saunders, J; Shackleford, DM; White, KL | 1 |
| Chen, Q; Guan, Y; Li, X; Liu, S; Zhang, Q | 1 |
| Carnovale, CE; Catania, VA; de Luján Alvarez, M; Francés, DE; Lambertucci, F; Martín-Sanz, P; Motiño, O; Quiroga, AD; Rigalli, JP; Ronco, MT; Villar, S | 1 |
| Bahia, MT; Caldas, IS; Caldas, S; Diniz, LF; Galvão, LMDC; Guedes, PMDM; Lima, WG; Nascimento, ÁFDSD | 1 |
| Castillo, C; Cramer, A; González-Herrera, F; Kemmerling, U; Liempi, A; Machado, FS; Maya, JD; Pimentel, P | 1 |
| He, T; Xing, Y; Yang, N; Zhang, W | 1 |
| Crukley, C; Desjardins, L; Hadway, J; Lee, TY; Morrison, L; Stewart, E; Wang, Y | 1 |
| Alves Lima, FC; Ferreira da Silva, AB; Gutierrez, FR; Nogueira Silva, JJ; Pavanelli, WR; Santana Silva, J; Wagner Franco, D | 1 |
| Grosset, J; Nuermberger, E; Tasneen, R; Tyagi, S; Williams, K | 1 |
| Banerjee, S; Mallia, MB; Mathur, A; Sarma, HD; Subramanian, S; Venkatesh, M | 1 |
| Arantes, JM; Bahia, MT; Carneiro, CM; de Abreu Vieira, PM; de Lana, M; Francisco, AF; Martins, HR; Pedrosa, ML; Silva, M; Tafuri, WL; Veloso, VM | 1 |
| Al-Shabrawey, M; Bartoli, M; Behzadian, MA; Caldwell, RB; Caldwell, RW; El-Remessy, AB; Istanboli, M; Labazi, M; Marcus, DM | 1 |
| Ackerstaff, E; Carlin, S; Cho, H; Humm, JL; Koutcher, JA; Ling, CC; Lupu, ME; O'Donoghue, J; Rizwan, A; Wang, Y; Zanzonico, PB | 1 |
| Fujibayashi, Y; Fujieda, S; Furukawa, T; Kobayashi, M; Kudo, T; Mori, T; Oh, M; Tanaka, T | 1 |
| Boutrid, H; Cebulla, CM; Feuer, WJ; Jockovich, ME; Lampidis, TJ; Murray, TG; Piña, Y | 1 |
| Baumann, M; Eckardt, A; Eicheler, W; Schuetze, C; Thames, H; Yaromina, A; Zips, D | 1 |
| Busk, M; Bussink, J; Hansen, KV; Horsman, MR; Jakobsen, S; Overgaard, J; van der Kogel, A | 1 |
| Aihara, K; Akaike, M; Fukuhara, Y; Gonzalez, FJ; Ishizawa, K; Izawa-Ishizawa, Y; Kanbara, T; Kitagawa, T; Kurobe, H; Lei, Y; Ono, S; Ripen, AM; Takahama, Y; Tamaki, T; Tomita, S; Ueki, M; Ueno, M; Urata, M; Yoshizumi, M | 1 |
| Andrade, SG; Portella, RS | 1 |
| Edwards, DA; Elbert, KJ; Garcia-Contreras, L; Hickey, AJ; Muttil, P; Padilla, D; Sung, JC; Telko, M; Verberkmoes, JL | 1 |
| Bendhack, LM; da Silva, GK; da Silva, RS; Do Valle Matta, MA; Franco, DW; Guedes, PM; Gutierrez, FR; Oliveira, FS; Rodrigues, GJ; Silva, JS; Zamboni, DS | 1 |
| Bol, A; Christian, N; De Bast, M; Deheneffe, S; Grégoire, V; Labar, D; Lee, JA | 1 |
| Araújo-Jorge, TC; Calvet, CM; de Castro, SL; Molina, JT; Olivieri, BP; Pereira, MC; Urbina, JA | 1 |
| Condon, D; Dhiman, M; Garg, NJ; Guan, Z; Gupta, S; Lui, C; Wen, JJ | 1 |
| Baumann, M; Flentje, M; Jakob, PM; Melkus, G; Mörchel, P; Yaromina, A; Zips, D | 1 |
| Baumann, M; Dörfler, A; Eicheler, W; Hering, S; Leichtner, T; Thames, H; Yaromina, A; Zhou, X; Zips, D | 1 |
| Boutrid, H; Celdran, M; Feuer, W; Hernandez, E; Houston, SK; Lampidis, TJ; Murray, TG; Piña, Y; Shi, W | 1 |
| Babaev, AA; Golubiatnikov, GY; Ivanova, IP; Kamensky, VA; Maslennikova, AV; Orlova, AG; Plekhanov, VI; Prianikova, TI; Shakhova, NM; Snopova, LB; Turchin, IV | 1 |
| Cecic, IK; Erler, JT; Felsher, D; Giaccia, AJ; Graves, EE; Le, QT; Sayles, L; Sweet-Cordero, A; Tran, PT; Vilalta, M | 1 |
| Bourdin Trunz, B; Bray, MA; Brun, R; Kaiser, M; Mazué, G; Pécoul, B; Torreele, E; Tweats, D | 1 |
| Carnovale, C; Francés, D; Manarin, R; Revelli, S; Ronco, MT; Serra, E | 1 |
| Brun, R; Jędrysiak, R; Kaiser, M; Suwiński, J; Torreele, E; Trunz, BB; Tweats, D | 1 |
| Forsback, S; Heinonen, SE; Knuuti, J; Laine, VJ; Roivainen, A; Saraste, A; Saukko, P; Silvola, JM; Ylä-Herttuala, S | 1 |
| Bahia, MT; Cunha-Filho, MS; de Andrade, IM; de Paula, LM; Figueiredo, VP; Maximiano, FP; Sá-Barreto, LC; Talvani, A | 1 |
| Bifani, P; Dartois, V; Heng, Y; Hervé, M; Kiass, M; Mathys, V; Seah, PG; Siew, JY; Singhal, A; Tay, HC | 1 |
| Barrett, MP; Brun, R; Don, R; Jacobs, RT; Wang, MZ | 1 |
| Busk, M; Horsman, MR; Jakobsen, S; Mortensen, LS; Nordsmark, M; Overgaard, J; Theil, J | 1 |
| Combes, V; Grau, GE; Hempel, C; Hunt, NH; Kurtzhals, JA | 1 |
| Andries, K; Li, SY; Mdluli, KE; Nuermberger, EL; Peloquin, CA; Tasneen, R; Taylor, D; Williams, KN | 1 |
| Aleixo, DL; de Araújo, SM; de Melo, CS; do Nascimento, A; Ferraz, FN; Gomes, ML; Simoni, GK; Spack, M | 1 |
| Bali, S; Bhutta, MF; Brown, SD; Cheeseman, MT; Hilton, H; Hough, TA; Parker, A; Pathak, P; Potter, PK; Purnell, T; Romero, MR; Tyrer, HE; Vizor, L; Vowell, K; Wells, S; Williams, D | 1 |
| Bishai, WR; Davis, SL; Harper, J; Jain, SK; Kramnik, I; Nuermberger, EL; Pomper, MG; Skerry, C; Tasneen, R; Weir, M | 1 |
| Fairlamb, AH; Kime, R; Norval, S; Patterson, S; Read, KD; Simeons, FR; Stojanovski, L; Wyllie, S | 1 |
| Civelek, AC; Huang, T; Jiang, H; Li, J; Li, XF; Ng, CK; Postel, GC; Shen, B | 1 |
| Carlier, Y; Cencig, S; Coltel, N; Truyens, C | 1 |
| Bahia, MT; Caldas, IS; de Andrade, IM; Diniz, Lde F; do Nascimento, ÁF; Martins, TA; Ribeiro, I; Talvani, A; Torreele, E; Trunz, BB | 1 |
| Bachmann, S; Dietrich, A; Kaminski, H; Mathia, S; Mrowka, R; Mutig, K; Paliege, A; Rosenberger, C | 1 |
| Ataide Soares, K; Bahia, MT; Carneiro, CM; Chiari, E; Galvão, LM; Guedes, PM; Lana, Md; Tafuri, WL; Veloso, VM | 1 |
| Adomat, H; Bowden, M; Dragowska, W; Gleave, M; Koch, CJ; Skov, K; Woo, J; Yapp, DT | 1 |
| Beck, R; Kumar, P; Machulla, HJ; McEwan, AJ; Picchio, M; Piert, M; Reischl, G; Schwaiger, M; Wester, HJ; Wiebe, LI; Ziegler, S | 1 |
| Basombrío, MA; Cardozo, R; Corrales, M; Segura, MA; Urbina, JA | 1 |
| Ahmed, SU; Furuichi, S; Hori, H; Kan, S; Kasai, S; Nagasawa, H; Okamoto, M; Oshikawa, T; Sasai, A; Sato, M; Tano, T; Uto, Y | 1 |
| Bishai, W; Grosset, J; Lounis, N; Nuermberger, E; Rosenthal, I; Tyagi, S; Williams, K; Yoshimatsu, T | 1 |
| Driscoll, DK; Gruppo, V; Johnson, CM; Lenaerts, AJ; Marietta, KS; Orme, IM; Reynolds, RC; Rose, JD; Tompkins, NM | 1 |
| Baeza, I; Chena, MA; Elizondo, S; Nogueda, B; Rodríguez-Páez, L; Wong, C | 1 |
| Angus, PW; Burrell, LM; Cooper, ME; Lew, RA; Paizis, G; Schembri, JM; Shaw, T; Smith, AI; Tikellis, C; Warner, FJ; Zuilli, A | 1 |
| Bleiz, J; Buschiazzo, H; Del Buono, MB; Drut, R; Kozubsky, L; Lirussi, D; Luong, T; Marron, A; Quijano, G; Zaidenberg, A | 1 |
| Almeida, D; Bishai, WR; Grosset, JH; Nuermberger, E; Peloquin, CA; Rosenthal, I; Tyagi, S; Williams, KN | 1 |
| de Arias, AR; de Bilbao, NV; Ferreira, ME; Fournet, A; Hocquemiller, R; Lagoutte, D; Nakayama, H; Poupon, E; Schinini, A; Serna, E; Soriano-Agatón, F | 1 |
| Aly, S; Bange, FC; Brandau, S; Ehlers, S; Keller, C; Malm, S; Malzan, A; Wagner, K | 1 |
| Barry, CE; Dowd, CS; Krahenbuhl, JL; Lahiri, R; Manjunatha, UH; Randhawa, B | 1 |
| Bustamante, JM; Enders, JE; Fernández, AR; Fretes, RE; Paglini-Oliva, P; Presti, MS; Rivarola, HW | 1 |
| Doyle, PS; Engel, JC; McKerrow, JH; Zhou, YM | 1 |
| Brader, P; Fong, Y; Hricak, H; Humm, JL; Ling, CC; Reid, V; Riedl, CC; Wen, B; Woo, Y; Zanzonico, P | 1 |
| Almeida, D; Grosset, JH; Nuermberger, E; Rosenthal, I; Tasneen, R; Tyagi, S; Williams, KN | 1 |
| Allen, SS; Barry, CE; Carrillo, J; Cho, SN; Eum, SY; Flynn, JL; Gonzales, J; Klein, E; Lee, EG; Lin, PL; Manjunatha, U; McMurray, DN; Park, SK; Raleigh, JA; Ray, SM; Taylor, K; Via, LE | 1 |
| Neal, RA | 1 |
| Kuczynski, B; Patel, B; Rumsey, WL | 1 |
| Adams, GE; Horsman, MR; Khalil, AA; Overgaard, J; Steinberg, F; Stratford, IJ; Streffer, C; Wood, PJ | 1 |
| Arteel, GE; Iimuro, Y; Raleigh, JA; Thurman, RG; Yin, M | 1 |
| Busza, AL; Gadian, DG; Gordon, I; Lythgoe, MF; McEwan, AJ; Wiebe, L; Williams, SR | 1 |
| Bonté, F; Ferreira, ME; Fournet, A; Lavault, M; Nakayama, H; Rojas de Arias, A; Samudio, M; Schinini, A; Torres de Ortiz, S; Vera de Bilbao, N | 1 |
| Bouteille, B; Chauviere, G | 1 |
| Bernsen, HJ; Jeuken, JW; Peters, H; Raleigh, JA; Rijken, PF; van der Kogel, AJ; Wesseling, P | 1 |
| Bussink, J; Kaanders, JH; Strik, AM; van der Kogel, AJ | 1 |
| Thurman, RG | 1 |
| Bottasso, OA; Piaggio, E; Pitashny, M; Revelli, SS; Roggero, E; Wietzerbin, J | 1 |
| Ferreira, ME; Fournet, A; Nakayama, H; Rojas de Arias, A; Schinini, A; Torres, S; Vera de Bilbao, N | 1 |
| Hamilton-Miller, JM | 1 |
| Bleehen, NM; Owen, LN; White, RA; Workman, P | 1 |
| Dulaney, EL; Frost, BM; Valiant, ME | 1 |
| Jennings, FW | 1 |
| Andrade, SG; Freitas, LA; Santiago, CM; Silva, RC | 1 |
| Price, KE; Tsai, YH | 1 |
| Smith, GR | 1 |
7 review(s) available for azomycin and Disease Models, Animal
| Article | Year |
|---|---|
The effect of benznidazole dose among the efficacy outcome in the murine animal model. A quantitative integration of the literature.
Topics: Animals; Chagas Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Mice; Nifurtimox; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Experimental and Clinical Treatment of Chagas Disease: A Review.
Topics: Animals; Chagas Disease; Chronic Disease; Clinical Trials as Topic; Disease Models, Animal; Drug Compounding; Humans; Incidence; Latin America; Nanoparticles; Nifurtimox; Nitroimidazoles; Observational Studies as Topic; Randomized Controlled Trials as Topic; Tissue Distribution; Trypanocidal Agents; Trypanosoma cruzi | 2017 |
Development of novel drugs for human African trypanosomiasis.
Topics: Animals; Antiprotozoal Agents; Benzoxazoles; Clinical Trials as Topic; Disease Models, Animal; Drug Evaluation, Preclinical; Haplorhini; Humans; Mice; Neglected Diseases; Nitroimidazoles; Trypanosoma brucei brucei; Trypanosomiasis, African | 2011 |
Experimental amoebiasis and the development of anti-amoebic compounds.
Topics: Acetamides; Amebiasis; Amebicides; Animals; Chemical Phenomena; Chemistry; Disease Models, Animal; Drug Evaluation, Preclinical; Entamoeba histolytica; Entamoebiasis; Nitroimidazoles | 1983 |
[Use of megazol for the treatment of trypanosomiasis].
Topics: Acetanilides; Animals; Anti-Infective Agents; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Metronidazole; Mice; Nitroimidazoles; Thiadiazoles; Trypanocidal Agents; Trypanosomiasis | 1999 |
Sex-related liver injury due to alcohol involves activation of Kupffer cells by endotoxin.
Topics: Animals; Cell Hypoxia; Diet; Disease Models, Animal; Endotoxins; Ethanol; Female; Kupffer Cells; Lipopolysaccharide Receptors; Lipopolysaccharides; Liver Diseases, Alcoholic; Male; Nitroimidazoles; Radiation-Sensitizing Agents; Rats; Sex Factors; Tumor Necrosis Factor-alpha | 2000 |
Antimicrobial agents acting against anaerobes.
Topics: Aminoglycosides; Anaerobiosis; Animals; Anti-Bacterial Agents; Bacteria; Chloramphenicol; Clindamycin; Colistin; Disease Models, Animal; Erythromycin; Fusidic Acid; Humans; Lactams; Lincomycin; Microbial Sensitivity Tests; Nitrofurans; Nitroimidazoles; Polymyxins; Rifamycins; Sulfamethoxazole; Tetracyclines; Trimethoprim; Vancomycin | 1975 |
177 other study(ies) available for azomycin and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
β -[
Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Fluorine Radioisotopes; Male; Mice; Mice, Nude; Neoplasms; Nitroimidazoles; Positron-Emission Tomography; Radiochemistry; Radiopharmaceuticals; Tissue Distribution; Tumor Hypoxia | 2017 |
Aspirin-triggered resolvin D1 reduces parasitic cardiac load by decreasing inflammation in a murine model of early chronic Chagas disease.
Topics: Animals; Chagas Cardiomyopathy; Chronic Disease; Disease Models, Animal; Docosahexaenoic Acids; Female; Heart; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Nitroimidazoles; Parasite Load; Receptors, Formyl Peptide; Trypanosoma cruzi | 2021 |
Benznidazole Anti-Inflammatory Effects in Murine Cardiomyocytes and Macrophages Are Mediated by Class I PI3Kδ.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Chagas Cardiomyopathy; Chromones; Class I Phosphatidylinositol 3-Kinases; Disease Models, Animal; Female; Humans; Lipopolysaccharides; Macrophages; Male; Mice; Morpholines; Myocytes, Cardiac; Nitroimidazoles; Primary Cell Culture; RAW 264.7 Cells | 2021 |
4-nitrobenzoylcoumarin potentiates the antiparasitic, anti-inflammatory and cardioprotective effects of benznidazole in a murine model of acute Trypanosoma cruzi infection.
Topics: Animals; Anti-Inflammatory Agents; Antiparasitic Agents; Chagas Disease; Disease Models, Animal; Mice; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi | 2022 |
Experimental Combination Therapy with Amiodarone and Low-Dose Benznidazole in a Mouse Model of Trypanosoma cruzi Acute Infection.
Topics: Amiodarone; Animals; Chagas Disease; Disease Models, Animal; Drug Therapy, Combination; Heart; Heart Diseases; Heart Function Tests; Humans; Male; Mice; Nitroimidazoles; Parasitemia; Trypanosoma cruzi | 2022 |
Novel Regimens of Bedaquiline-Pyrazinamide Combined with Moxifloxacin, Rifabutin, Delamanid and/or OPC-167832 in Murine Tuberculosis Models.
Topics: Animals; Antibiotics, Antitubercular; Antitubercular Agents; Diarylquinolines; Disease Models, Animal; Drug Administration Schedule; Drug Therapy, Combination; Isoniazid; Mice; Mice, Inbred BALB C; Moxifloxacin; Mycobacterium tuberculosis; Nitroimidazoles; Oxazoles; Pyrazinamide; Rifabutin; Tuberculosis | 2022 |
Nitroimidazopyrazinones with Oral Activity against Tuberculosis and Chagas Disease in Mouse Models of Infection.
Topics: Animals; Chagas Disease; Disease Models, Animal; Mice; Mycobacterium tuberculosis; Nitroimidazoles; Nitroreductases; Trypanosoma cruzi; Tuberculosis | 2022 |
Dynamic
Topics: Animals; Antitubercular Agents; Diarylquinolines; Disease Models, Animal; Humans; Linezolid; Mice; Mycobacterium tuberculosis; Nitroimidazoles; Rabbits; Tuberculosis, Meningeal; Tuberculosis, Multidrug-Resistant | 2022 |
Treatment with benznidazole and pentoxifylline regulates microRNA transcriptomic profile in a murine model of Chagas chronic cardiomyopathy.
Topics: Animals; Chagas Cardiomyopathy; Chagas Disease; Disease Models, Animal; Fibrosis; Gene Expression Profiling; Mice; MicroRNAs; Nitroimidazoles; Pentoxifylline; Transcriptome; Trypanocidal Agents; Trypanosoma cruzi | 2023 |
Effectiveness of the repurposed drug isotretinoin in an experimental murine model of Chagas disease.
Topics: Animals; Chagas Disease; Disease Models, Animal; Isotretinoin; Mice; Mice, Inbred C57BL; Nitroimidazoles; Pharmaceutical Preparations; Trypanocidal Agents; Trypanosoma cruzi | 2023 |
Activity of the sesquiterpene lactone goyazensolide against
Topics: Animals; Bridged-Ring Compounds; Cell Line; Cell Survival; Chagas Disease; Disease Models, Animal; Furans; Mice; Nitroimidazoles; Sesquiterpenes; Sesterterpenes; Survival Analysis; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Effects of Photodynamic Therapy with Redaporfin on Tumor Oxygenation and Blood Flow in a Lung Cancer Mouse Model.
Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Kaplan-Meier Estimate; Lung Neoplasms; Mice, Inbred C57BL; Nitroimidazoles; Oxygen; Perfusion; Photochemotherapy; Porphyrins; Sulfonamides; Tissue Distribution; Tumor Hypoxia; Vascular Endothelial Growth Factor A | 2019 |
Efficacy of the Benznidazole+Posaconazole combination therapy in parasitemia reduction: An experimental murine model of acute Chagas.
Topics: Acute Disease; Animals; Chagas Disease; Disease Models, Animal; Disease Progression; DNA, Protozoan; Drug Therapy, Combination; Nitroimidazoles; Parasite Load; Parasitemia; Rats; Rats, Wistar; Triazoles; Trypanocidal Agents | 2020 |
Antiparasitic and anti-inflammatory activities of ß-lapachone-derived naphthoimidazoles in experimental acute Trypanosoma cruzi infection.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Chagas Disease; Disease Models, Animal; Electrocardiography; Male; Mice; Naphthoquinones; Nitroimidazoles; Parasitemia; Time Factors; Trypanocidal Agents | 2020 |
Benznidazole/Poloxamer 407 Solid Dispersion as a New Strategy to Improve the Treatment of Experimental Trypanosoma cruzi Infection.
Topics: Acute Disease; Animals; Antibodies, Protozoan; Aspartate Aminotransferases; Chagas Disease; Chronic Disease; Disease Models, Animal; Excipients; Female; Heart; Mice; Myocardium; Nitroimidazoles; Parasitemia; Poloxamer; Quadriceps Muscle; Random Allocation; Real-Time Polymerase Chain Reaction; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Thioridazine aggravates skeletal myositis, systemic and liver inflammation in Trypanosoma cruzi-infected and benznidazole-treated mice.
Topics: Acetylglucosaminidase; Animals; Chagas Disease; Cytokines; Disease Models, Animal; Drug Combinations; Female; Glycogen; Hepatitis; Mice; Muscle, Skeletal; Myositis; NADH, NADPH Oxidoreductases; Nitroimidazoles; Parasite Load; Parasitemia; Peroxidase; Thioridazine; Transaminases; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Long term follow-up of Trypanosoma cruzi infection and Chagas disease manifestations in mice treated with benznidazole or posaconazole.
Topics: Administration, Oral; Animals; Chagas Disease; Disease Models, Animal; Follow-Up Studies; Male; Mice, Inbred C57BL; Nitroimidazoles; Polymerase Chain Reaction; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Topics: Acute Disease; Animals; Chagas Disease; Disease Models, Animal; Female; Mice; Nanoparticles; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
Detection of Low Oxygen Microenvironments in a Murine Model of Invasive Pulmonary Aspergillosis Using Pimonidazole.
Topics: Animals; Aspergillus fumigatus; Cell Hypoxia; Cellular Microenvironment; Disease Models, Animal; Fluorescent Antibody Technique; Host-Pathogen Interactions; Invasive Pulmonary Aspergillosis; Lung; Mice; Microscopy, Fluorescence; Nitroimidazoles; Oxygen | 2021 |
Superior Efficacy of a Bedaquiline, Delamanid, and Linezolid Combination Regimen in a Mouse Tuberculosis Model.
Topics: Animals; Antitubercular Agents; Diarylquinolines; Disease Models, Animal; Drug Therapy, Combination; Linezolid; Mice; Mycobacterium tuberculosis; Nitroimidazoles; Oxazoles; Pyrazinamide; Recurrence; Tuberculosis | 2021 |
Deep-learning and MR images to target hypoxic habitats with evofosfamide in preclinical models of sarcoma.
Topics: Animals; Artificial Intelligence; Cell Line, Tumor; Deep Learning; Disease Models, Animal; Doxorubicin; Ecosystem; Female; Humans; Hypoxia; Magnetic Resonance Imaging; Mice; Mice, Inbred C3H; Mice, SCID; Nitroimidazoles; Phosphoramide Mustards; Prodrugs; Sarcoma; Soft Tissue Neoplasms; Xenograft Model Antitumor Assays | 2021 |
Nanocarrier-enhanced intracellular delivery of benznidazole for treatment of Trypanosoma cruzi infection.
Topics: Animals; Chagas Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Carriers; Mice; Nanoparticle Drug Delivery System; Nitroimidazoles; Phagocytes; Polyethylene Glycols; Sulfides; Trypanocidal Agents; Trypanosoma cruzi | 2021 |
6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]thiazoles: Facile synthesis and comparative appraisal against tuberculosis and neglected tropical diseases.
Topics: Animals; Antitubercular Agents; Chagas Disease; Disease Models, Animal; Mice; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Nitroimidazoles; Oxazoles; Structure-Activity Relationship; Thiazoles; Tuberculosis | 2017 |
Dose-dependent effect and pharmacokinetics of fexinidazole and its metabolites in a mouse model of human African trypanosomiasis.
Topics: Animals; Antiprotozoal Agents; Cerebral Cortex; Cerebrospinal Fluid; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hippocampus; Luminescent Measurements; Mice; Nitroimidazoles; Plasma; Treatment Outcome; Trypanosoma; Trypanosomiasis, African; Whole Body Imaging | 2017 |
Bactericidal and Sterilizing Activity of a Novel Regimen with Bedaquiline, Pretomanid, Moxifloxacin, and Pyrazinamide in a Murine Model of Tuberculosis.
Topics: Animals; Antitubercular Agents; Diarylquinolines; Disease Models, Animal; Female; Fluoroquinolones; Mice; Mice, Inbred BALB C; Moxifloxacin; Mycobacterium tuberculosis; Nitroimidazoles; Pyrazinamide; Tuberculosis, Pulmonary | 2017 |
Radiotherapy Synergizes with the Hypoxia-Activated Prodrug Evofosfamide: In Vitro and In Vivo Studies.
Topics: Animals; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Disease Models, Animal; DNA Damage; Humans; Hypoxia; Mice; Nitroimidazoles; Oxidation-Reduction; Phosphoramide Mustards; Prodrugs; Radiotherapy; Tumor Burden; Xenograft Model Antitumor Assays | 2018 |
In Vivo Imaging of Retinal Hypoxia Using HYPOX-4-Dependent Fluorescence in a Mouse Model of Laser-Induced Retinal Vein Occlusion (RVO).
Topics: Animals; Disease Models, Animal; Fluorescein Angiography; Fluoresceins; Fluorescent Dyes; Hypoxia; Image Processing, Computer-Assisted; Macular Edema; Male; Mice; Mice, Inbred C57BL; Nitroimidazoles; Radiation-Sensitizing Agents; Retinal Neovascularization; Retinal Vein; Retinal Vein Occlusion; Tomography, Optical Coherence | 2017 |
Cordyceps sinensis promotes immune regulation and enhances bacteriostatic activity of PA-824 via IL-10 in Mycobacterium tuberculosis disease.
Topics: Animals; Anti-Bacterial Agents; Blotting, Western; Cordyceps; Disease Models, Animal; Flow Cytometry; Immunomodulation; Interleukin-10; Male; Mice; Mice, Inbred CBA; Mycobacterium tuberculosis; Nitroimidazoles; Real-Time Polymerase Chain Reaction; Tuberculosis, Pulmonary | 2017 |
Dual Mechanism of Action of 5-Nitro-1,10-Phenanthroline against Mycobacterium tuberculosis.
Topics: Animals; Antitubercular Agents; Autophagy; Cell Line, Tumor; Disease Models, Animal; Escherichia coli; Female; Humans; Macrophages; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Mycobacterium bovis; Mycobacterium smegmatis; Mycobacterium tuberculosis; Nitroimidazoles; Phenanthrolines; Structure-Activity Relationship; THP-1 Cells; Tuberculosis, Multidrug-Resistant | 2017 |
Genome-wide mutagenesis and multi-drug resistance in American trypanosomes induced by the front-line drug benznidazole.
Topics: Animals; Chagas Disease; Disease Models, Animal; Drug Resistance, Multiple; Female; Genome, Protozoan; Mice, SCID; Mutagenesis; Mutagens; Mutation; Nitroimidazoles; Sequence Analysis, DNA; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2017 |
Assessment of a pretomanid analogue library for African trypanosomiasis: Hit-to-lead studies on 6-substituted 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8-oxides.
Topics: Administration, Oral; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Mice; Molecular Structure; Nitroimidazoles; Small Molecule Libraries; Structure-Activity Relationship; Trypanosomiasis, African | 2018 |
Elucidating the impact of low doses of nano-formulated benznidazole in acute experimental Chagas disease.
Topics: Animals; Antibodies, Protozoan; Cell Line; Chagas Disease; Chlorocebus aethiops; Disease Models, Animal; DNA, Protozoan; Drug Carriers; Female; Heart; Inflammation; Mice; Mice, Inbred C3H; Nanoparticles; Nitroimidazoles; Reactive Oxygen Species; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2017 |
Novel Pyrimidines as Antitubercular Agents.
Topics: Animals; Antitubercular Agents; Disease Models, Animal; Drug Design; Drug Stability; Female; Humans; Mice; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Nitroimidazoles; Pyrimidines; Solubility; Structure-Activity Relationship; Tuberculosis | 2018 |
Evaluation of Vascularity, Blood Perfusion, and Oxygen Tension in Tumor Xenografts with Fluorescent Microscopy.
Topics: Animals; Disease Models, Animal; Fluorescent Antibody Technique; Heterografts; Humans; Hypoxia; Mice; Microscopy, Fluorescence; Neoplasm Staging; Neoplasms; Neovascularization, Pathologic; Nitroimidazoles; Oxygen | 2018 |
Molecular and biological characterization of a highly pathogenic Trypanosoma cruzi strain isolated from a patient with congenital infection.
Topics: Animals; Brain; Chagas Disease; Chlorocebus aethiops; Disease Models, Animal; DNA, Protozoan; Female; Heart; Humans; Infant; Infectious Disease Transmission, Vertical; Inhibitory Concentration 50; Male; Mice; Mice, Inbred BALB C; Muscle, Skeletal; Myocardium; Nifurtimox; Nitroimidazoles; Parasitemia; Random Allocation; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2018 |
Administration of Hypoxia-Activated Prodrug Evofosfamide after Conventional Adjuvant Therapy Enhances Therapeutic Outcome and Targets Cancer-Initiating Cells in Preclinical Models of Colorectal Cancer.
Topics: Animals; Biomarkers; Caspases; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Chemoradiotherapy; Colorectal Neoplasms; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Synergism; Female; Humans; Hypoxia; Male; Mice; Neoplastic Stem Cells; Nitroimidazoles; Phenotype; Phosphoramide Mustards; Positron-Emission Tomography; Prodrugs; Standard of Care; Wnt Signaling Pathway; Xenograft Model Antitumor Assays | 2018 |
Outcome of E1224-Benznidazole Combination Treatment for Infection with a Multidrug-Resistant Trypanosoma cruzi Strain in Mice.
Topics: Animals; Combined Modality Therapy; Disease Models, Animal; Drug Interactions; Female; Mice; Microbial Sensitivity Tests; Nitroimidazoles; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2018 |
Positron Emission Tomography (PET) and Pharmacokinetics: Classical Blood Sampling Versus Image-Derived Analysis of [18F]FAZA and [18F]FDG in a Murine Tumor Bearing Model.
Topics: Animals; Breast Neoplasms; Disaccharides; Disease Models, Animal; Female; Kinetics; Mice; Mice, Inbred BALB C; Nitroimidazoles; Positron-Emission Tomography; Tissue Distribution | 2018 |
Multi-kinetic release of benznidazole-loaded multiparticulate drug delivery systems based on polymethacrylate interpolyelectrolyte complexes.
Topics: Adhesiveness; Administration, Oral; Animals; Capsules; Chagas Disease; Disease Models, Animal; Drug Carriers; Drug Compounding; Drug Delivery Systems; Drug Liberation; Gelatin; Hydrophobic and Hydrophilic Interactions; Kinetics; Male; Mice, Inbred BALB C; Nitroimidazoles; Particle Size; Polyelectrolytes; Polymethacrylic Acids; Rheology; Solubility; Spectroscopy, Fourier Transform Infrared; Technology, Pharmaceutical; Trypanocidal Agents | 2018 |
Anti-parasitic effect of vitamin C alone and in combination with benznidazole against Trypanosoma cruzi.
Topics: Animals; Ascorbic Acid; Body Weight; Chagas Disease; Chlorocebus aethiops; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Female; Mice, Inbred C3H; Nitroimidazoles; Parasite Load; Parasitemia; Survival Analysis; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2018 |
Parasitaemia and parasitic load are limited targets of the aetiological treatment to control the progression of cardiac fibrosis and chronic cardiomyopathy in Trypanosoma cruzi-infected dogs.
Topics: Acute Disease; Animals; Chagas Cardiomyopathy; Chronic Disease; Collagen Type III; Disease Models, Animal; Disease Progression; DNA, Protozoan; Dogs; Drug Resistance; Fibrosis; Heart; Myocardium; Nitroimidazoles; Parasite Load; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
Hydroxymethylnitrofurazone treatment in indeterminate form of chronic Chagas disease: Reduced intensity of tissue parasitism and inflammation-A histopathological study.
Topics: Animals; Chagas Disease; Disease Models, Animal; Inflammation; Kidney; Liver; Male; Mice; Muscle, Skeletal; Nitrofurazone; Nitroimidazoles; Trypanosoma cruzi | 2018 |
The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi.
Topics: Acute Disease; Adrenergic beta-Antagonists; Animals; Carvedilol; Catalase; Chagas Disease; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Heart; Male; Mice, Inbred C57BL; Myocardium; Nitroimidazoles; Oxidative Stress; Parasitemia; Protein Carbonylation; Reference Values; Reproducibility of Results; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Time Factors; Trypanocidal Agents; Trypanosoma cruzi | 2018 |
Indirubin derivatives are potent and selective anti-Trypanosoma cruzi agents.
Topics: Animals; Chagas Disease; Disease Models, Animal; Female; Flow Cytometry; Indoles; Mice; Mice, Inbred BALB C; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi | 2018 |
Successful Aspects of the Coadministration of Sterol 14α-Demethylase Inhibitor VFV and Benznidazole in Experimental Mouse Models of Chagas Disease Caused by the Drug-Resistant Strain of Trypanosoma cruzi.
Topics: 14-alpha Demethylase Inhibitors; Animals; Chagas Disease; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Humans; Male; Mice; Nitroimidazoles; Protozoan Proteins; Sterol 14-Demethylase; Trypanocidal Agents; Trypanosoma cruzi | 2019 |
In Vivo Ester Hydrolysis as a New Approach in Development of Positron Emission Tomography Tracers for Imaging Hypoxia.
Topics: Animals; Cell Hypoxia; Cell Line, Tumor; Disease Models, Animal; Esters; Female; Fluorine Radioisotopes; Hydrolysis; Hypoxia; Male; Mice; Mice, Inbred BALB C; Neoplasms; Nitroimidazoles; Positron-Emission Tomography; Radioactive Tracers; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2019 |
In vitro activity and in vivo efficacy of fexinidazole against New World Leishmania species.
Topics: Administration, Oral; Animals; Antiprotozoal Agents; Disease Models, Animal; Female; Leishmania; Leishmaniasis; Male; Mesocricetus; Mice, Inbred BALB C; Nitroimidazoles | 2019 |
Concomitant exercise training attenuates the cardioprotective effects of pharmacological therapy in a murine model of acute infectious myocarditis.
Topics: Animals; Antioxidants; Cardiotonic Agents; Catalase; Chagas Cardiomyopathy; Chagas Disease; Cytokines; Disease Models, Animal; Heart; Inflammation; Interleukin-10; Male; Myocarditis; Myocardium; Nitric Oxide; Nitroimidazoles; Parasitemia; Physical Conditioning, Animal; Rats; Rats, Wistar; Superoxide Dismutase; Trypanosoma cruzi; Tumor Necrosis Factor-alpha | 2019 |
Technical feasibility of [
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Disease Models, Animal; Feasibility Studies; Female; Glioblastoma; Nitroimidazoles; Positron-Emission Tomography; Radiopharmaceuticals; Radiotherapy Dosage; Radiotherapy, Image-Guided; Rats, Inbred F344; Treatment Outcome; Tumor Burden; Tyrosine | 2019 |
Detection of cellular hypoxia by pimonidazole adduct immunohistochemistry in kidney disease: methodological pitfalls and their solution.
Topics: Acute Kidney Injury; Animals; Antibodies, Monoclonal; Antibody Specificity; Artifacts; Cell Hypoxia; Disease Models, Animal; False Positive Reactions; Immunohistochemistry; Kidney; Nitroimidazoles; Polycystic Kidney Diseases; Predictive Value of Tests; Rats, Inbred Lew; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; Reperfusion Injury; Reproducibility of Results | 2019 |
Could pre-infection exercise training improve the efficacy of specific antiparasitic chemotherapy for Chagas disease?
Topics: Animals; Antiparasitic Agents; Cardiotonic Agents; Chagas Disease; Cytokines; Disease Models, Animal; Drug Administration Schedule; Heart; Male; Myocarditis; Nitroimidazoles; Parasitemia; Physical Conditioning, Animal; Rats; Rats, Wistar; Running; Trypanosoma cruzi | 2019 |
Clomipramine and benznidazole association for the treatment of acute experimental Trypanosoma cruzi infection.
Topics: Animals; Chagas Disease; Clomipramine; Disease Models, Animal; Drug Evaluation, Preclinical; Electrocardiography; Female; Intestines; Kidney; Liver; Male; Mice; Muscle, Skeletal; Myocardium; Nitroimidazoles; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi | 2013 |
Combined treatment with benznidazole and allopurinol in mice infected with a virulent Trypanosoma cruzi isolate from Nicaragua.
Topics: Allopurinol; Animals; Antibodies, Protozoan; Chagas Disease; Disease Models, Animal; Drug Therapy, Combination; Mice; Nicaragua; Nitroimidazoles; Survival Analysis; Treatment Outcome; Trypanosoma cruzi | 2013 |
Remote post-conditioning reduces hypoxic damage early after experimental stroke.
Topics: Animals; Blotting, Western; Disease Models, Animal; Femoral Vein; Hypoxia, Brain; Male; Nitroimidazoles; Radiation-Sensitizing Agents; Rats; Rats, Wistar; Reperfusion Injury; Stroke | 2013 |
In vivo activity of ursolic and oleanolic acids during the acute phase of Trypanosoma cruzi infection.
Topics: Acute Disease; Administration, Oral; Animals; Anti-Infective Agents; Chagas Disease; Disease Models, Animal; Infusions, Parenteral; Interferon-gamma; Interleukin-10; Male; Melastomataceae; Mice; Mice, Inbred BALB C; Nitroimidazoles; Oleanolic Acid; Parasitemia; Random Allocation; Triterpenes; Trypanocidal Agents; Ursolic Acid | 2013 |
Potent rifamycin-sparing regimen cures guinea pig tuberculosis as rapidly as the standard regimen.
Topics: Animals; Antitubercular Agents; Area Under Curve; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, Combination; Female; Guinea Pigs; Lung; Mycobacterium tuberculosis; Nitroimidazoles; Organ Size; Pyrazinamide; Recurrence; Rifamycins; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary | 2013 |
Synergistic induction of apoptosis in multiple myeloma cells by bortezomib and hypoxia-activated prodrug TH-302, in vivo and in vitro.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Drug Screening Assays, Antitumor; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Mice, Inbred C57BL; Multiple Myeloma; Nitroimidazoles; Phosphoramide Mustards; Pyrazines; Signal Transduction | 2013 |
Characterization of biological features of a rat F98 GBM model: a PET-MRI study with [18F]FAZA and [18F]FDG.
Topics: Animals; Cell Differentiation; Cell Line, Tumor; Disease Models, Animal; Fluorodeoxyglucose F18; Glioblastoma; Humans; Magnetic Resonance Imaging; Male; Nitroimidazoles; Positron-Emission Tomography; Rats; Survival Analysis | 2013 |
Benznidazole and posaconazole in experimental Chagas disease: positive interaction in concomitant and sequential treatments.
Topics: Animals; Antiprotozoal Agents; Chagas Disease; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Female; Mice; Nitroimidazoles; Parasitemia; Treatment Outcome; Triazoles; Trypanosoma cruzi | 2013 |
Anti-adrenergic and muscarinic receptor autoantibodies in a canine model of Chagas disease and their modulation by benznidazole.
Topics: Animals; Autoantibodies; Chagas Cardiomyopathy; Disease Models, Animal; Dogs; Humans; Immunosuppressive Agents; Nitroimidazoles; Receptor, Muscarinic M2; Receptors, Adrenergic, beta | 2014 |
Intrahepatic microcirculatory disorder, parenchymal hypoxia and NOX4 upregulation result in zonal differences in hepatocyte apoptosis following lipopolysaccharide- and D-galactosamine-induced acute liver failure in rats.
Topics: Aldehydes; Animals; Apoptosis; Caspase 3; Disease Models, Animal; Fluconazole; Galactosamine; Hepatocytes; Hypoxia-Inducible Factor 1; Lipopolysaccharides; Liver; Liver Failure, Acute; Macrophages; Male; Microcirculation; NADPH Oxidase 4; NADPH Oxidases; Nitroimidazoles; Oxidative Stress; Rats; Rats, Wistar; Rhodamines; Up-Regulation | 2014 |
Sesquiterpene lactone in nanostructured parenteral dosage form is efficacious in experimental Chagas disease.
Topics: Animals; Chagas Disease; Disease Models, Animal; Female; Lactones; Mice; Nanocapsules; Nitroimidazoles; Sesquiterpenes; Trypanosoma cruzi | 2014 |
Renal oxygenation in acute renal ischemia-reperfusion injury.
Topics: Acute Kidney Injury; Animals; Biomarkers; Cell Hypoxia; Disease Models, Animal; Fluorescence; Glomerular Filtration Rate; Hemoglobins; Immunohistochemistry; Kidney; Laser-Doppler Flowmetry; Male; Models, Cardiovascular; Nitroimidazoles; Oxygen; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Renal Circulation; Reperfusion Injury; Reproducibility of Results; Severity of Illness Index; Time Factors | 2014 |
Antitrypanosomal activity of fexinidazole metabolites, potential new drug candidates for Chagas disease.
Topics: Administration, Oral; Animals; Biotransformation; Chagas Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Mice; Nitroimidazoles; Sulfones; Sulfoxides; Survival Analysis; Trypanocidal Agents; Trypanosoma cruzi | 2014 |
Pharmacokinetics-pharmacodynamics analysis of bicyclic 4-nitroimidazole analogs in a murine model of tuberculosis.
Topics: Animals; Caco-2 Cells; Cell Line, Tumor; Disease Models, Animal; Female; Humans; Mice; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Nitroimidazoles; Retrospective Studies; Tuberculosis | 2014 |
PA-824 is as effective as isoniazid against latent tuberculosis infection in C3HeB/FeJ mice.
Topics: Animals; Antitubercular Agents; Disease Models, Animal; Female; Isoniazid; Latent Tuberculosis; Lung; Mice; Mice, Inbred C3H; Mycobacterium tuberculosis; Nitroimidazoles; Rifampin | 2014 |
In vitro and in vivo activities of the nitroimidazole TBA-354 against Mycobacterium tuberculosis.
Topics: Animals; Antitubercular Agents; Caco-2 Cells; Cell Line, Tumor; Disease Models, Animal; Drug Interactions; Drug Resistance, Bacterial; Female; Humans; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Nitroimidazoles; Oxazines; Oxazoles; Tuberculosis | 2015 |
Contribution of the nitroimidazoles PA-824 and TBA-354 to the activity of novel regimens in murine models of tuberculosis.
Topics: Animals; Antitubercular Agents; Clofazimine; Diarylquinolines; Disease Models, Animal; Drug Therapy, Combination; Female; Fluoroquinolones; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Moxifloxacin; Mycobacterium tuberculosis; Nitroimidazoles; Oxazines; Oxazoles; Pyrazinamide; Random Allocation; Tuberculosis | 2015 |
Nitroimidazo-oxazole compound DNDI-VL-2098: an orally effective preclinical drug candidate for the treatment of visceral leishmaniasis.
Topics: Administration, Oral; Animals; Antiprotozoal Agents; Chemistry, Pharmaceutical; Cricetinae; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Compounding; Drug Evaluation, Preclinical; Female; Humans; Inhibitory Concentration 50; Leishmania donovani; Leishmaniasis, Visceral; Mice; Mice, Inbred BALB C; Nitric Oxide; Nitric Oxide Synthase Type II; Nitroimidazoles; Parasitic Sensitivity Tests; Time Factors | 2015 |
Potential role of hypoxia imaging using (18)F-FAZA PET to guide hypoxia-driven interventions (carbogen breathing or dose escalation) in radiation therapy.
Topics: Animals; Carbon Dioxide; Cell Hypoxia; Diagnostic Imaging; Disease Models, Animal; Glioma; Male; Nitroimidazoles; Oximetry; Oxygen; Partial Pressure; Positron-Emission Tomography; Prognosis; Radiotherapy Planning, Computer-Assisted; Random Allocation; Rats; Rats, Inbred F344; Rhabdomyosarcoma | 2014 |
Predictive value of (18)F-FAZA PET imaging for guiding the association of radiotherapy with nimorazole: a preclinical study.
Topics: Animals; Cell Hypoxia; Chemoradiotherapy; Disease Models, Animal; Fluorine Radioisotopes; Glioma; Male; Nimorazole; Nitroimidazoles; Positron-Emission Tomography; Radiopharmaceuticals; Random Allocation; Rats; Rats, Inbred F344; Rhabdomyosarcoma | 2015 |
Experimental benznidazole treatment of Trypanosoma cruzi II strains isolated from children of the Jequitinhonha Valley, Minas Gerais, Brazil, with Chagas disease.
Topics: Animals; Antibodies, Protozoan; Area Under Curve; Brazil; Chagas Disease; Child; Disease Models, Animal; Drug Resistance; Enzyme-Linked Immunosorbent Assay; Female; Fibrosis; Flow Cytometry; Humans; Inflammation; Mice; Myocardium; Nitroimidazoles; Parasitemia; Polymerase Chain Reaction; Primary Cell Culture; Remission Induction; Statistics, Nonparametric; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Synthesis and structure-activity relationships for extended side chain analogues of the antitubercular drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).
Topics: Administration, Oral; Animals; Antitubercular Agents; Biological Availability; Chemistry Techniques, Synthetic; Chronic Disease; Disease Models, Animal; Humans; Male; Mice, Inbred BALB C; Mice, Inbred Strains; Microbial Sensitivity Tests; Microsomes, Liver; Mycobacterium tuberculosis; Nitroimidazoles; Oxazoles; Rats, Sprague-Dawley; Structure-Activity Relationship; Tuberculosis | 2015 |
Trypanocidal effect of the benzyl ester of N-propyl oxamate: a bi-potential prodrug for the treatment of experimental Chagas disease.
Topics: Alcohol Oxidoreductases; Animals; Cell Line; Cell Survival; Chagas Disease; Disease Models, Animal; Esters; Isoenzymes; Male; Mice; Nifurtimox; Nitroimidazoles; Oxamic Acid; Prodrugs; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Immunohistochemical evidence of stress and inflammatory markers in mouse models of cutaneous leishmaniosis.
Topics: Animals; Biomarkers; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Immunohistochemistry; Inflammation; Leishmania; Leishmaniasis, Cutaneous; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nitric Oxide; Nitroimidazoles; p38 Mitogen-Activated Protein Kinases; Vascular Endothelial Growth Factor A | 2015 |
Limited Ability of Posaconazole To Cure both Acute and Chronic Trypanosoma cruzi Infections Revealed by Highly Sensitive In Vivo Imaging.
Topics: Animals; Antifungal Agents; Chagas Disease; Chronic Disease; Disease Models, Animal; Female; Mice; Mice, Inbred BALB C; Mice, SCID; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Benznidazole/Itraconazole Combination Treatment Enhances Anti-Trypanosoma cruzi Activity in Experimental Chagas Disease.
Topics: Animals; Antibodies, Protozoan; Chagas Disease; Disease Models, Animal; Drug Therapy, Combination; Female; Immunoglobulin G; Itraconazole; Mice; Myocardium; Nitroimidazoles; Parasite Load; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
The Effects of Pulsed Radiation Therapy on Tumor Oxygenation in 2 Murine Models of Head and Neck Squamous Cell Carcinoma.
Topics: Animals; Carcinoma, Squamous Cell; Cell Hypoxia; Coloring Agents; Disease Models, Animal; Female; Fluorodeoxyglucose F18; Head and Neck Neoplasms; Heterografts; Mice; Mice, Nude; Misonidazole; Neoplasm Recurrence, Local; Nitroimidazoles; Oxygen Consumption; Positron-Emission Tomography; Radiopharmaceuticals; Squamous Cell Carcinoma of Head and Neck; Tumor Burden | 2015 |
Preliminary research on 1-(4-bromo-2-nitroimidazol-1-yl)-3-[(18)F]fluoropropan-2-ol as a novel brain hypoxia PET tracer in a rodent model of stroke.
Topics: Animals; Cell Line; Disease Models, Animal; Hypoxia, Brain; Male; Mice; Molecular Structure; Nitroimidazoles; Positron-Emission Tomography; Propanols; Rats; Rats, Inbred F344; Stroke | 2015 |
Antitrypanosomal Treatment with Benznidazole Is Superior to Posaconazole Regimens in Mouse Models of Chagas Disease.
Topics: 14-alpha Demethylase Inhibitors; Administration, Oral; Animals; Chagas Disease; Clinical Trials, Phase II as Topic; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Heart; Humans; Immunosuppression Therapy; Mice; NIH 3T3 Cells; Nitroimidazoles; Parasitemia; Recurrence; Sterol 14-Demethylase; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
The in vivo trypanocidal effect of the diterpene 5-epi-icetexone obtained from Salvia gilliesii.
Topics: Administration, Oral; Animals; Chagas Disease; Dimethyl Sulfoxide; Disease Models, Animal; Diterpenes; Heart; Mice; Muscle, Skeletal; Myocardium; Nitroimidazoles; Parasitemia; Salvia; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Different Therapeutic Outcomes of Benznidazole and VNI Treatments in Different Genders in Mouse Experimental Models of Trypanosoma cruzi Infection.
Topics: 14-alpha Demethylase Inhibitors; Animals; Chagas Disease; Cytochrome P-450 Enzyme System; Disease Models, Animal; Drug Administration Schedule; Drug Evaluation, Preclinical; Female; Gene Expression; Imidazoles; Immunosuppressive Agents; Male; Mice; Nitroimidazoles; Oxadiazoles; Parasitemia; Sex Factors; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Contribution of Oxazolidinones to the Efficacy of Novel Regimens Containing Bedaquiline and Pretomanid in a Mouse Model of Tuberculosis.
Topics: Animals; Antitubercular Agents; Bacterial Load; Diarylquinolines; Disease Models, Animal; Drug Administration Schedule; Drug Combinations; Drug Resistance, Multiple, Bacterial; Drug Synergism; Female; Linezolid; Lung; Mice; Mice, Inbred BALB C; Mycobacterium tuberculosis; Nitroimidazoles; Organophosphates; Oxazoles; Oxazolidinones; Pyrazinamide; Time Factors; Treatment Outcome; Tuberculosis, Pulmonary | 2016 |
Hypoxia-Activated Prodrug TH-302 Targets Hypoxic Bone Marrow Niches in Preclinical Leukemia Models.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Cell Line, Tumor; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Humans; Hypoxia; Leukemia; Magnetic Resonance Imaging; Mice; Nitroimidazoles; Phosphoramide Mustards; Prodrugs; Treatment Outcome; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2016 |
Synthesis and evaluation of pretomanid (PA-824) oxazolidinone hybrids.
Topics: Animals; Antitubercular Agents; Chronic Disease; Disease Models, Animal; Mice; Mice, Inbred C57BL; Mycobacterium tuberculosis; Nitroimidazoles; Oxazolidinones; Tuberculosis | 2016 |
In Vitro and In Vivo Trypanosomicidal Action of Novel Arylimidamides against Trypanosoma cruzi.
Topics: Amides; Amidines; Animals; Chagas Disease; Disease Models, Animal; Drug Administration Schedule; Drug Dosage Calculations; Drug Synergism; Drug Therapy, Combination; Female; Mice; Nitroimidazoles; Parasite Load; Parasitemia; Parasitic Sensitivity Tests; Structure-Activity Relationship; Survival Analysis; Terphenyl Compounds; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Low-dose benznidazole treatment results in parasite clearance and attenuates heart inflammatory reaction in an experimental model of infection with a highly virulent Trypanosoma cruzi strain.
Topics: Animals; Cells, Cultured; Chagas Cardiomyopathy; Chagas Disease; Creatine Kinase; Disease Models, Animal; Dose-Response Relationship, Drug; Heart; Humans; Immunologic Factors; Inflammation; Interleukin-6; Mice; Mice, Inbred BALB C; Myocytes, Cardiac; NF-kappa B; Nitric Oxide Synthase Type II; Nitroimidazoles; Parasite Load; Parasitemia; Trypanocidal Agents; Trypanosoma cruzi; Tumor Necrosis Factor-alpha | 2016 |
Clomipramine and Benznidazole Act Synergistically and Ameliorate the Outcome of Experimental Chagas Disease.
Topics: Animals; Chagas Disease; Clomipramine; Disease Models, Animal; Drug Administration Schedule; Drug Combinations; Drug Synergism; Heart; Male; Mice; Mice, Inbred BALB C; Nitroimidazoles; Parasitemia; Parasitic Sensitivity Tests; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis.
Topics: Administration, Oral; Animals; Antiprotozoal Agents; Antitubercular Agents; Biotransformation; Disease Models, Animal; Drug Administration Schedule; Drug Dosage Calculations; Drug Repositioning; Female; Hormesis; Leishmania donovani; Leishmaniasis, Visceral; Mice; Mice, Inbred BALB C; Nitroimidazoles; Oxazoles; Parasitic Sensitivity Tests; Treatment Outcome | 2016 |
DYT-40, a novel synthetic 2-styryl-5-nitroimidazole derivative, blocks malignant glioblastoma growth and invasion by inhibiting AEG-1 and NF-κB signaling pathways.
Topics: Animals; Antineoplastic Agents; Cell Adhesion Molecules; Cell Line, Tumor; Disease Models, Animal; Glioblastoma; Histocytochemistry; Humans; Immunohistochemistry; Membrane Proteins; Microscopy; NF-kappa B; Nitroimidazoles; Rats; RNA-Binding Proteins; Signal Transduction; Treatment Outcome | 2016 |
Cerebral and extracerebral vulnerability to hypoxic insults after diffuse traumatic brain injury in rats.
Topics: Animals; Arterial Pressure; Brain; Brain Injuries, Traumatic; Disease Models, Animal; Hypotension; Hypoxia; Hypoxia, Brain; Kidney; Liver; Male; Myocardium; Nitroimidazoles; Rats; Rats, Sprague-Dawley | 2016 |
Efficacy of Lychnopholide Polymeric Nanocapsules after Oral and Intravenous Administration in Murine Experimental Chagas Disease.
Topics: Acute Disease; Administration, Intravenous; Administration, Oral; Animals; Chagas Disease; Chronic Disease; Delayed-Action Preparations; Disease Models, Animal; Drug Compounding; Humans; Lactones; Mice; Nanocapsules; Nitroimidazoles; Polyethylene Glycols; Sesquiterpenes; Survival Analysis; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver Cancer.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Cell Proliferation; Circulating Tumor DNA; Combined Modality Therapy; Disease Models, Animal; Doxorubicin; Ethiodized Oil; Humans; Liver Neoplasms; Nitroimidazoles; Phosphoramide Mustards; Rabbits; Tumor Hypoxia | 2017 |
Quantitative [
Topics: Animals; Biomarkers, Tumor; Cell Line, Tumor; Disease Models, Animal; Female; Fluorescent Antibody Technique; Mammary Neoplasms, Animal; Misonidazole; Nitroimidazoles; Positron-Emission Tomography; Receptor, ErbB-2; Trastuzumab; Tumor Burden; Tumor Hypoxia | 2017 |
Nitroheterocyclic drugs cure experimental Trypanosoma cruzi infections more effectively in the chronic stage than in the acute stage.
Topics: Animals; Area Under Curve; Chagas Disease; Disease Models, Animal; Female; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Nifurtimox; Nitroimidazoles; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi | 2016 |
Synthesis and Biological Evaluation of a New Nitroimidazole-99mTc-Complex for Imaging of Hypoxia in Mice Model.
Topics: A549 Cells; Animals; Biological Availability; Cell Hypoxia; Cell Line, Tumor; Disease Models, Animal; Humans; Imino Acids; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Nitroimidazoles; Organotechnetium Compounds; Radiopharmaceuticals | 2016 |
Benznidazole, the trypanocidal drug used for Chagas disease, induces hepatic NRF2 activation and attenuates the inflammatory response in a murine model of sepsis.
Topics: Animals; Antioxidants; Chagas Disease; Disease Models, Animal; Down-Regulation; Inflammation; Liver; Male; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Nitroimidazoles; Oxidative Stress; Sepsis; Toll-Like Receptor 4; Trypanocidal Agents | 2017 |
Myocarditis in different experimental models infected by Trypanosoma cruzi is correlated with the production of IgG1 isotype.
Topics: Animals; Chagas Disease; Disease Models, Animal; Dogs; Immunoglobulin G; Male; Mice; Myocarditis; Nitroimidazoles; Trypanosoma cruzi | 2017 |
Simvastatin Attenuates Endothelial Activation through 15-Epi-Lipoxin A4 Production in Murine Chronic Chagas Cardiomyopathy.
Topics: Animals; Anticholesteremic Agents; Arachidonate 5-Lipoxygenase; Chagas Cardiomyopathy; Chronic Disease; Disease Models, Animal; Drug Therapy, Combination; E-Selectin; Endothelium; Gene Expression Regulation; Humans; Intercellular Adhesion Molecule-1; Lipoxins; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Myocardium; Nitroimidazoles; Parasitemia; Simvastatin; Survival Analysis; Trypanocidal Agents; Trypanosoma cruzi; Vascular Cell Adhesion Molecule-1 | 2017 |
Silencing of galectin-1 inhibits retinal neovascularization and ameliorates retinal hypoxia in a murine model of oxygen-induced ischemic retinopathy.
Topics: Animals; Animals, Newborn; Blotting, Western; Disease Models, Animal; Galectin 1; Gene Silencing; Hypoxia; Intravitreal Injections; Ischemia; Mice; Mice, Inbred C57BL; Nitroimidazoles; Oxygen; Real-Time Polymerase Chain Reaction; Retinal Neovascularization; RNA; RNA, Messenger | 2017 |
Assessment of intratumor hypoxia by integrated 18F-FDG PET / perfusion CT in a liver tumor model.
Topics: Animals; Disease Models, Animal; Fluorodeoxyglucose F18; Glucose; Humans; Hypoxia; Liver Neoplasms; Male; Neovascularization, Pathologic; Nitroimidazoles; Oxygen Consumption; Perfusion; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Rabbits | 2017 |
Complexation of the anti-Trypanosoma cruzi drug benznidazole improves solubility and efficacy.
Topics: Animals; Chagas Disease; Disease Models, Animal; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred BALB C; Nitroimidazoles; Spectrophotometry, Ultraviolet; Trypanocidal Agents; Trypanosoma cruzi | 2008 |
Enhanced bactericidal activity of rifampin and/or pyrazinamide when combined with PA-824 in a murine model of tuberculosis.
Topics: Animals; Antibiotics, Antitubercular; Antitubercular Agents; Colony Count, Microbial; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Female; Isoniazid; Lung; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Nitroimidazoles; Pyrazinamide; Recurrence; Rifampin; Tuberculosis, Pulmonary | 2008 |
On the isolation and evaluation of a novel unsubstituted 5-nitroimidazole derivative as an agent to target tumor hypoxia.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Hypoxia; Mice; Molecular Structure; Neoplasms; Nitroimidazoles; Organotechnetium Compounds | 2008 |
Trypanosoma cruzi: effect of benznidazole therapy combined with the iron chelator desferrioxamine in infected mice.
Topics: Analysis of Variance; Animals; Chagas Disease; Deferoxamine; Disease Models, Animal; Drug Therapy, Combination; Hemoglobins; Iron; Liver; Male; Mice; Nitroimidazoles; Parasitemia; Polymerase Chain Reaction; Random Allocation; Siderophores; Trypanocidal Agents; Trypanosoma cruzi | 2008 |
HMG-CoA reductase inhibitors (statin) prevents retinal neovascularization in a model of oxygen-induced retinopathy.
Topics: Animals; Blotting, Western; Capillaries; Disease Models, Animal; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Indoles; Infant, Newborn; Intercellular Adhesion Molecule-1; Lipid Peroxidation; Mice; Nitroimidazoles; Oxygen; Phosphorylation; Retinal Neovascularization; Retinal Vessels; Retinopathy of Prematurity; STAT3 Transcription Factor; Superoxides; Vascular Endothelial Growth Factor A | 2009 |
Noninvasive multimodality imaging of the tumor microenvironment: registered dynamic magnetic resonance imaging and positron emission tomography studies of a preclinical tumor model of tumor hypoxia.
Topics: Animals; Autoradiography; Cell Hypoxia; Disease Models, Animal; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Misonidazole; Nitroimidazoles; Positron-Emission Tomography; Prostatic Neoplasms; Radiopharmaceuticals; Rats | 2009 |
Radio-copper-labeled Cu-ATSM: an indicator of quiescent but clonogenic cells under mild hypoxia in a Lewis lung carcinoma model.
Topics: Animals; Autoradiography; Bromodeoxyuridine; Carcinoma, Lewis Lung; Cell Proliferation; Colony-Forming Units Assay; Coordination Complexes; Copper Radioisotopes; Disease Models, Animal; Fluorodeoxyglucose F18; Hypoxia; Image Processing, Computer-Assisted; Immunohistochemistry; Ki-67 Antigen; Male; Mice; Nitroimidazoles; Organometallic Compounds; Positron-Emission Tomography; Staining and Labeling; Thiosemicarbazones | 2009 |
Increased hypoxia following vessel targeting in a murine model of retinoblastoma.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Carboplatin; Disease Models, Animal; Hypoxia; Mice; Mice, Transgenic; Microscopy, Confocal; Neovascularization, Pathologic; Nitroimidazoles; Pregnadienediols; Retinal Neoplasms; Retinoblastoma | 2009 |
Core needle biopsies for determination of the microenvironment in individual tumours for longitudinal radiobiological studies.
Topics: Animals; Biopsy, Needle; Carcinoma, Squamous Cell; Confidence Intervals; Disease Models, Animal; Dose Fractionation, Radiation; Dose-Response Relationship, Radiation; Environment; Female; Humans; Hypoxia; Immunohistochemistry; Longitudinal Studies; Male; Mice; Mice, Nude; Neoplasm Transplantation; Nitroimidazoles; Probability; Radiobiology; Random Allocation; Reference Values | 2009 |
Can hypoxia-PET map hypoxic cell density heterogeneity accurately in an animal tumor model at a clinically obtainable image contrast?
Topics: Animals; Carcinoma, Squamous Cell; Cell Count; Cell Hypoxia; Disease Models, Animal; Female; Hypoxia; Mice; Mice, Inbred C3H; Nitroimidazoles; Oxygen; Positron-Emission Tomography; Radiopharmaceuticals; Random Allocation; Sensitivity and Specificity; Tissue Distribution | 2009 |
Synthesis and structure-activity studies of biphenyl analogues of the tuberculosis drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).
Topics: Animals; Antitubercular Agents; Disease Models, Animal; Drug Evaluation, Preclinical; Mice; Mice, Inbred BALB C; Molecular Structure; Mycobacterium tuberculosis; Nitroimidazoles; Stereoisomerism; Structure-Activity Relationship | 2010 |
Role of hypoxia-inducible factor 1alpha in T cells as a negative regulator in development of vascular remodeling.
Topics: Animals; Antibody Formation; Arteriosclerosis; Cell Hypoxia; Cell Proliferation; Chemokine CXCL12; Chemotaxis, Leukocyte; Cytokines; Disease Models, Animal; Femoral Artery; Hyperplasia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunity, Cellular; Immunohistochemistry; Lymphocyte Activation; Male; Mice; Mice, Knockout; Nitroimidazoles; Receptors, Antigen, T-Cell; T-Lymphocytes; Thymus Gland; Time Factors; Tunica Intima | 2010 |
Trypanosoma cruzi: parasite antigens sequestered in heart interstitial dendritic cells are related to persisting myocarditis in benznidazole-treated mice.
Topics: Animals; Antibodies, Monoclonal; Antigens, Protozoan; Chagas Cardiomyopathy; Dendritic Cells; Disease Models, Animal; Drug Resistance; Mice; Myocarditis; Myocardium; Nitroimidazoles; Time Factors; Trypanocidal Agents; Trypanosoma cruzi | 2009 |
Dry powder PA-824 aerosols for treatment of tuberculosis in guinea pigs.
Topics: Administration, Inhalation; Administration, Oral; Aerosols; Animals; Antitubercular Agents; Chemistry, Pharmaceutical; Colony Count, Microbial; Disease Models, Animal; Extensively Drug-Resistant Tuberculosis; Guinea Pigs; Humans; Latent Tuberculosis; Lung; Male; Nitroimidazoles; Particle Size; Powders; Spleen; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary | 2010 |
Nitric oxide donor trans-[RuCl([15]aneN)NO] as a possible therapeutic approach for Chagas' disease.
Topics: Animals; Chagas Cardiomyopathy; Chagas Disease; Disease Models, Animal; Drug Resistance; Drug Synergism; Female; Humans; Macrophages; Mice; Nitric Oxide; Nitric Oxide Donors; Nitroimidazoles; Organometallic Compounds; Parasitemia; Survival Rate; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
Is (18)F-FDG a surrogate tracer to measure tumor hypoxia? Comparison with the hypoxic tracer (14)C-EF3 in animal tumor models.
Topics: Animals; Carbon Radioisotopes; Disease Models, Animal; Fiducial Markers; Fluorodeoxyglucose F18; Hypoxia; Male; Mice; Neoplasms; Nitroimidazoles; Radionuclide Imaging | 2010 |
A comparative study of posaconazole and benznidazole in the prevention of heart damage and promotion of trypanocidal immune response in a murine model of Chagas disease.
Topics: Animals; Antiprotozoal Agents; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chagas Cardiomyopathy; Chagas Disease; Disease Models, Animal; Female; Heart; Humans; Mice; Myocardium; Nitroimidazoles; Survival Analysis; Triazoles; Trypanosoma cruzi | 2010 |
Phenyl-alpha-tert-butyl-nitrone and benzonidazole treatment controlled the mitochondrial oxidative stress and evolution of cardiomyopathy in chronic chagasic Rats.
Topics: Analysis of Variance; Animals; Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Cyclic N-Oxides; Disease Models, Animal; Disease Progression; Heart Function Tests; Hemodynamics; Lipid Peroxidation; Mitochondria, Heart; Nitroimidazoles; Oxidative Stress; Probability; Random Allocation; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Trypanosoma cruzi | 2010 |
Correlating quantitative MR measurements of standardized tumor lines with histological parameters and tumor control dose.
Topics: Animals; Carcinoma, Squamous Cell; Cell Hypoxia; Disease Models, Animal; Dose Fractionation, Radiation; Dose-Response Relationship, Radiation; Humans; Immunohistochemistry; Lactic Acid; Magnetic Resonance Imaging; Mice; Mice, Nude; Neoplasm Transplantation; Nitroimidazoles; Oxygen Consumption; Radiation Dosage; Radiation-Sensitizing Agents; Sensitivity and Specificity; Transplantation, Heterologous | 2010 |
Radiobiological hypoxia, histological parameters of tumour microenvironment and local tumour control after fractionated irradiation.
Topics: Animals; Carcinoma, Squamous Cell; Cell Division; Cell Hypoxia; Confidence Intervals; Disease Models, Animal; Dose Fractionation, Radiation; Dose-Response Relationship, Radiation; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Neovascularization, Pathologic; Nitroimidazoles; Radiation Tolerance; Radiation-Sensitizing Agents; Radiobiology; Transplantation, Heterologous; Tumor Microenvironment | 2010 |
Focal, periocular delivery of 2-deoxy-D-glucose as adjuvant to chemotherapy for treatment of advanced retinoblastoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Deoxyglucose; Disease Models, Animal; Drug Delivery Systems; Hypoxia; Mice; Mice, Transgenic; Microscopy, Fluorescence; Nitroimidazoles; Retinal Neoplasms; Retinoblastoma; Tumor Burden | 2010 |
Comparative study of tumor hypoxia by diffuse optical spectroscopy and immunohistochemistry in two tumor models.
Topics: Animals; Biomarkers, Tumor; Brain Neoplasms; Diffusion; Disease Models, Animal; Female; Hemoglobins; Hypoxia; Immunohistochemistry; Lymph Nodes; Male; Medical Oncology; Nitroimidazoles; Optical Devices; Oxygen; Radiation-Sensitizing Agents; Rats; Spectrum Analysis | 2010 |
Hypoxia in models of lung cancer: implications for targeted therapeutics.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Electrodes; Histones; Humans; Lung Neoplasms; Male; Mice; Mice, Nude; Neoplasms, Experimental; Nitrogen Mustard Compounds; Nitroimidazoles; Oxygen; Positron-Emission Tomography; Proto-Oncogene Proteins c-myc; ras Proteins | 2010 |
Synthesis and structure-activity relationships of aza- and diazabiphenyl analogues of the antitubercular drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).
Topics: Animals; Antitubercular Agents; Disease Models, Animal; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred BALB C; Nitroimidazoles; Oxazines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Tuberculosis | 2010 |
Fexinidazole--a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness.
Topics: Administration, Oral; Animals; Antiprotozoal Agents; Disease Models, Animal; Dogs; Female; Inhibitory Concentration 50; Mice; Nitroimidazoles; Parasitic Sensitivity Tests; Rats; Treatment Outcome; Trypanosomiasis, African | 2010 |
Benznidazole treatment attenuates liver NF-κB activity and MAPK in a cecal ligation and puncture model of sepsis.
Topics: Animals; Cecum; Disease Models, Animal; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Exudates and Transudates; Gene Expression Regulation; Leukocyte Count; Ligation; Liver; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide Synthase Type II; Nitroimidazoles; p38 Mitogen-Activated Protein Kinases; Punctures; RNA, Messenger; Sepsis; Time Factors; Tumor Necrosis Factor-alpha | 2011 |
1-Aryl-4-nitro-1H-imidazoles, a new promising series for the treatment of human African trypanosomiasis.
Topics: Animals; Antiprotozoal Agents; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Humans; Leukocytes, Mononuclear; Mice; Molecular Structure; Mutagenicity Tests; Nitroimidazoles; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Trypanosomiasis, African | 2011 |
Detection of hypoxia by [18F]EF5 in atherosclerotic plaques in mice.
Topics: Analysis of Variance; Animals; Aorta; Apolipoprotein B-100; Atherosclerosis; Autoradiography; Disease Models, Animal; Etanidazole; Female; Fluorine Radioisotopes; Genotype; Hydrocarbons, Fluorinated; Hypoxia; Immunohistochemistry; Insulin-Like Growth Factor II; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitroimidazoles; Phenotype; Positron-Emission Tomography; Radiopharmaceuticals; Receptors, LDL; Tissue Distribution | 2011 |
Benznidazole microcrystal preparation by solvent change precipitation and in vivo evaluation in the treatment of Chagas disease.
Topics: Animals; Chagas Disease; Chemical Precipitation; Disease Models, Animal; Drug Compounding; Drug Delivery Systems; Excipients; Female; Hardness Tests; Hypromellose Derivatives; Methylcellulose; Mice; Nitroimidazoles; Polymers; Solubility; Solvents; Tablets; Trypanocidal Agents; Trypanosoma cruzi | 2011 |
Mycobacterium tuberculosis infection induces hypoxic lung lesions in the rat.
Topics: Animals; Disease Models, Animal; Female; Granuloma; Hypoxia; Immunohistochemistry; Lung; Mycobacterium tuberculosis; Nitroimidazoles; Rats; Tuberculosis, Pulmonary | 2011 |
Accessing radiation response using hypoxia PET imaging and oxygen sensitive electrodes: a preclinical study.
Topics: Animals; Cell Hypoxia; Disease Models, Animal; Electrodes; Female; Fluorine Radioisotopes; Mammary Neoplasms, Experimental; Mice; Nitroimidazoles; Positron-Emission Tomography; Prognosis; Radiation Tolerance | 2011 |
CNS hypoxia is more pronounced in murine cerebral than noncerebral malaria and is reversed by erythropoietin.
Topics: Animals; Brain; Disease Models, Animal; Erythropoietin; Female; Fluorescent Dyes; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Malaria, Cerebral; Mice; Nitroimidazoles; Parasitemia; Plasmodium berghei; Poly(ADP-ribose) Polymerases; Survival Analysis; Treatment Outcome | 2011 |
Sterilizing activity of novel TMC207- and PA-824-containing regimens in a murine model of tuberculosis.
Topics: Animals; Antibiotics, Antitubercular; Antitubercular Agents; Colony Count, Microbial; Diarylquinolines; Disease Models, Animal; Drug Administration Schedule; Drug Therapy, Combination; Mice; Mice, Inbred BALB C; Mycobacterium tuberculosis; Nitroimidazoles; Quinolines; Secondary Prevention; Treatment Outcome; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary | 2011 |
Different forms of administration of biotherapy 7dH in mice experimentally infected by Trypanosoma cruzi produce different effects.
Topics: Animals; Chagas Disease; Disease Models, Animal; Homeopathy; Male; Mice; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2011 |
HIF-VEGF pathways are critical for chronic otitis media in Junbo and Jeff mouse mutants.
Topics: Animals; Blister; Body Fluids; Cell Hypoxia; Disease Models, Animal; Ear, Middle; Gene Expression Regulation; Hearing Loss; HSP90 Heat-Shock Proteins; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indoles; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Mutant Strains; Nitroimidazoles; Otitis Media with Effusion; Phthalazines; Pyridines; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Sunitinib; Vascular Endothelial Growth Factor A | 2011 |
Mouse model of necrotic tuberculosis granulomas develops hypoxic lesions.
Topics: Animals; Antitubercular Agents; Aza Compounds; Disease Models, Animal; Fluoroquinolones; Gene Expression Profiling; Genes, Bacterial; Granuloma; Hypoxia; Immunohistochemistry; Male; Mice; Mice, Inbred C3H; Moxifloxacin; Mycobacterium tuberculosis; Nitroimidazoles; Positron-Emission Tomography; Pyrazinamide; Quinolines; Treatment Outcome; Tuberculosis | 2012 |
The anti-trypanosome drug fexinidazole shows potential for treating visceral leishmaniasis.
Topics: Administration, Oral; Animals; Biotransformation; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Leishmania donovani; Leishmaniasis, Visceral; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Nitroimidazoles; Nitroreductases; Parasitic Sensitivity Tests; Protozoan Proteins; Sulfones; Sulfoxides; Trypanocidal Agents | 2012 |
Tumor microenvironment-dependent 18F-FDG, 18F-fluorothymidine, and 18F-misonidazole uptake: a pilot study in mouse models of human non-small cell lung cancer.
Topics: Animals; Biological Transport; Bromodeoxyuridine; Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Dideoxynucleosides; Disease Models, Animal; Female; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Humans; Lung Neoplasms; Mice; Misonidazole; Necrosis; Nitroimidazoles; Pilot Projects; Positron-Emission Tomography; Radioactive Tracers; Tumor Microenvironment | 2012 |
Evaluation of benznidazole treatment combined with nifurtimox, posaconazole or AmBisome® in mice infected with Trypanosoma cruzi strains.
Topics: Amphotericin B; Animals; Chagas Disease; Disease Models, Animal; DNA, Protozoan; Drug Therapy, Combination; Female; Mice; Mice, Inbred BALB C; Nifurtimox; Nitroimidazoles; Parasite Load; Parasitemia; Real-Time Polymerase Chain Reaction; Treatment Outcome; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2012 |
Fexinidazole: a potential new drug candidate for Chagas disease.
Topics: Administration, Oral; Animals; Antiprotozoal Agents; Chagas Disease; Disease Models, Animal; Female; Mice; Nitroimidazoles; Parasitemia; Survival Analysis; Treatment Outcome; Trypanosoma cruzi | 2012 |
Chronic activation of vasopressin V2 receptor signalling lowers renal medullary oxygen levels in rats.
Topics: Animals; Deamino Arginine Vasopressin; Disease Models, Animal; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney Medulla; Nitroimidazoles; Oxygen; Rats; Rats, Brattleboro; Rats, Sprague-Dawley; Receptors, Vasopressin; Signal Transduction; Vasopressins | 2013 |
The dog as model for chemotherapy of the Chagas' disease.
Topics: Administration, Oral; Animals; Chagas Disease; Disease Models, Animal; Dogs; Drug Resistance; Female; Male; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 2002 |
Hypoxia in the androgen-dependent Shionogi model for prostate cancer at three stages.
Topics: Androgens; Animals; Cell Line, Tumor; Disease Models, Animal; Disease Progression; Flow Cytometry; Hypoxia; Image Cytometry; Male; Mammary Neoplasms, Animal; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Neoplasms, Hormone-Dependent; Nitroimidazoles; Prognosis; Prostatic Neoplasms; Protein Binding; Time Factors; Tumor Burden | 2004 |
Hypoxia-specific tumor imaging with 18F-fluoroazomycin arabinoside.
Topics: Animals; Cell Hypoxia; Disease Models, Animal; Female; Metabolic Clearance Rate; Mice; Mice, Inbred BALB C; Mice, Nude; Misonidazole; Neoplasms; Nitroimidazoles; Organ Specificity; Oxidation-Reduction; Oxygen; Radionuclide Imaging; Radiopharmaceuticals; Tissue Distribution | 2005 |
Comparative efficacies of TAK-187, a long-lasting ergosterol biosynthesis inhibitor, and benznidazole in preventing cardiac damage in a murine model of Chagas' disease.
Topics: Acute Disease; Animals; Chagas Cardiomyopathy; Chagas Disease; Disease Models, Animal; Ergosterol; Male; Mice; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2005 |
TX-1877, a bifunctional hypoxic cell radiosensitizer, enhances anticancer host response: immune cell migration and nitric oxide production.
Topics: Animals; Carcinoma, Squamous Cell; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Hypoxia; Cell Movement; Dendritic Cells; Disease Models, Animal; Humans; Mice; Nitric Oxide; Nitroimidazoles; Radiation Tolerance; T-Lymphocytes, Cytotoxic | 2005 |
Bactericidal activity of the nitroimidazopyran PA-824 in a murine model of tuberculosis.
Topics: Animals; Antitubercular Agents; Colony Count, Microbial; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Resistance, Bacterial; Female; Humans; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Nitroimidazoles; Random Allocation; Tuberculosis, Pulmonary | 2005 |
Preclinical testing of the nitroimidazopyran PA-824 for activity against Mycobacterium tuberculosis in a series of in vitro and in vivo models.
Topics: Animals; Antitubercular Agents; Colony Count, Microbial; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Humans; Lung; Mice; Mice, Inbred C57BL; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Nitroimidazoles; Specific Pathogen-Free Organisms; Spleen; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary | 2005 |
Trypanocidal activity of N-isopropyl oxamate on cultured epimastigotes and murine trypanosomiasis using different Trypanosoma cruzi strains.
Topics: Alcohol Oxidoreductases; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Kinetics; Mice; Models, Chemical; NAD; Nifurtimox; Nitroimidazoles; Oxamic Acid; Species Specificity; Time Factors; Trypanocidal Agents; Trypanosoma cruzi; Trypanosomiasis | 2005 |
Chronic liver injury in rats and humans upregulates the novel enzyme angiotensin converting enzyme 2.
Topics: Angiotensin I; Angiotensin-Converting Enzyme 2; Animals; Aorta, Thoracic; Carboxypeptidases; Cell Hypoxia; Cells, Cultured; Chronic Disease; Disease Models, Animal; Female; Hepatitis C, Chronic; Hepatocytes; Humans; Immunoenzyme Techniques; Liver; Liver Cirrhosis; Male; Nitroimidazoles; Peptide Fragments; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Up-Regulation; Vasodilation | 2005 |
Treatment of experimental chronic chagas disease with trifluralin.
Topics: Animals; Chagas Disease; Disease Models, Animal; Electrocardiography; Heart; Herbicides; Male; Mice; Mice, Inbred Strains; Myocarditis; Nitroimidazoles; Trifluralin; Trypanocidal Agents; Trypanosoma cruzi | 2006 |
Combination chemotherapy with the nitroimidazopyran PA-824 and first-line drugs in a murine model of tuberculosis.
Topics: Animals; Antibiotics, Antitubercular; Antitubercular Agents; Disease Models, Animal; Drug Therapy, Combination; Ethambutol; Female; Isoniazid; Mice; Mice, Inbred BALB C; Mycobacterium tuberculosis; Nitroimidazoles; Pyrazinamide; Rifampin; Secondary Prevention; Time Factors; Tuberculosis, Pulmonary | 2006 |
Effects of canthin-6-one alkaloids from Zanthoxylum chiloperone on Trypanosoma cruzi-infected mice.
Topics: Alkaloids; Animals; Carbolines; Chagas Disease; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Indole Alkaloids; Indoles; Male; Mice; Mice, Inbred BALB C; Naphthyridines; Nitroimidazoles; Survival Rate; Trypanocidal Agents; Trypanosoma cruzi; Zanthoxylum | 2007 |
Oxygen status of lung granulomas in Mycobacterium tuberculosis-infected mice.
Topics: Animals; Biomarkers; Disease Models, Animal; Electrodes; Female; Granuloma; Hypoxia; Immunohistochemistry; Lung; Mice; Mice, Inbred C57BL; Mutation; Mycobacterium tuberculosis; Necrosis; Nitrates; Nitroimidazoles; Oxygen; Time Factors; Tuberculosis, Pulmonary | 2006 |
Mycobacterium leprae is naturally resistant to PA-824.
Topics: Animals; Culture Media; Disease Models, Animal; Drug Resistance, Bacterial; Leprosy; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Mice, Nude; Microbial Sensitivity Tests; Mycobacterium leprae; Nitroimidazoles | 2006 |
Treatment with benznidazole or thioridazine in the chronic phase of experimental Chagas disease improves cardiopathy.
Topics: Animals; Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Disease Models, Animal; Drug Evaluation, Preclinical; Electrocardiography; Mice; Nitroimidazoles; Thioridazine; Trypanocidal Agents | 2007 |
A cysteine protease inhibitor cures Chagas' disease in an immunodeficient-mouse model of infection.
Topics: Animals; Cattle; Cells, Cultured; Chagas Disease; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Disease Models, Animal; Female; Homeodomain Proteins; Humans; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Knockout; Nifurtimox; Nitroimidazoles; Protozoan Proteins; Survival Analysis; Trypanocidal Agents; Trypanosoma cruzi | 2007 |
Tumor hypoxia imaging in orthotopic liver tumors and peritoneal metastasis: a comparative study featuring dynamic 18F-MISO and 124I-IAZG PET in the same study cohort.
Topics: Animals; Disease Models, Animal; Half-Life; Hypoxia; Liver Neoplasms, Experimental; Misonidazole; Monosaccharides; Nitroimidazoles; Peritoneal Neoplasms; Positron-Emission Tomography; Rats; Tissue Distribution | 2008 |
Powerful bactericidal and sterilizing activity of a regimen containing PA-824, moxifloxacin, and pyrazinamide in a murine model of tuberculosis.
Topics: Animals; Antitubercular Agents; Aza Compounds; Colony Count, Microbial; Disease Models, Animal; Drug Therapy, Combination; Female; Fluoroquinolones; Humans; Lung; Mice; Mice, Inbred BALB C; Moxifloxacin; Mycobacterium tuberculosis; Nitroimidazoles; Pyrazinamide; Quinolines; Treatment Outcome; Tuberculosis, Pulmonary | 2008 |
Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates.
Topics: Animals; Antitubercular Agents; Disease Models, Animal; Granuloma; Guinea Pigs; Humans; Hypoxia; Immunohistochemistry; Lung; Macaca fascicularis; Metronidazole; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mycobacterium tuberculosis; Nitroimidazoles; Oxygen; Rabbits; Radiation-Sensitizing Agents; Tuberculosis, Pulmonary | 2008 |
Detecting hypoxia in heart using phosphorescence quenching and 99mtechnetium-nitroimidazoles.
Topics: Animals; Cardiomyopathies; Disease Models, Animal; Dogs; Hypoxia; Luminescent Measurements; Myocardial Ischemia; Myocardium; Nitroimidazoles; Organotechnetium Compounds; Oxygen; Radionuclide Imaging | 1994 |
A comparison of the physiological effects of RSU1069 and RB6145 in the SCCVII murine tumour.
Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Disease Models, Animal; Female; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred C3H; Misonidazole; Neovascularization, Pathologic; Nitroimidazoles; Oxygen; Phosphorus Radioisotopes | 1996 |
Chronic enteral ethanol treatment causes hypoxia in rat liver tissue in vivo.
Topics: Animals; Aspartate Aminotransferases; Cell Hypoxia; Disease Models, Animal; Ethanol; Liver; Liver Diseases, Alcoholic; Male; Nitroimidazoles; Rats; Rats, Wistar | 1997 |
The relationship between magnetic resonance diffusion imaging and autoradiographic markers of cerebral blood flow and hypoxia in an animal stroke model.
Topics: Animals; Autoradiography; Cell Hypoxia; Cerebrovascular Circulation; Cerebrovascular Disorders; Diffusion; Disease Models, Animal; Magnetic Resonance Imaging; Male; Nitroimidazoles; Rats; Rats, Wistar; Technetium Tc 99m Exametazime | 1999 |
Efficacy of the bisbenzylisoquinoline alkaloids in acute and chronic Trypanosoma cruzi murine model.
Topics: Acute Disease; Administration, Oral; Alkaloids; Animals; Benzylisoquinolines; Chagas Disease; Chronic Disease; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Immunoblotting; Isoquinolines; Male; Mice; Mice, Inbred BALB C; Nitroimidazoles; Parasitemia; Trypanocidal Agents | 2000 |
Hypoxia in a human intracerebral glioma model.
Topics: Animals; Brain Neoplasms; Cell Division; Disease Models, Animal; Glioma; Hypoxia; Mice; Mice, Inbred BALB C; Microcirculation; Nitroimidazoles; Radiation-Sensitizing Agents | 2000 |
Effects of nicotinamide and carbogen on oxygenation in human tumor xenografts measured with luminescense based fiber-optic probes.
Topics: Analysis of Variance; Animals; Carbon Dioxide; Cell Hypoxia; Disease Models, Animal; Fiber Optic Technology; Humans; Linear Models; Luminescent Measurements; Niacinamide; Nitroimidazoles; Optical Fibers; Oxygen; Radiation-Sensitizing Agents; Sensitivity and Specificity; Transplantation, Heterologous; Tumor Cells, Cultured | 2000 |
Treatment with benznidazole and its immunomodulating effects on Trypanosoma cruzi-infected rats.
Topics: Adjuvants, Immunologic; Administration, Oral; Animals; Cells, Cultured; Chagas Disease; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Drug Therapy, Combination; Heart; Interferon-gamma; Macrophages, Peritoneal; Male; Myocarditis; Myocardium; Nitric Oxide; Nitroimidazoles; Parasitemia; Rats; Rats, Inbred Strains; Recombinant Proteins; Trypanocidal Agents; Trypanosoma cruzi | 2001 |
Experimental treatment of chronic Trypanosoma cruzi infection in mice with 2-n-propylquinoline.
Topics: Animals; Chagas Disease; Chronic Disease; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Male; Mice; Mice, Inbred BALB C; Nitroimidazoles; Phytotherapy; Plant Extracts; Quinolines; Rutaceae; Trypanocidal Agents; Trypanosoma cruzi | 2001 |
The penetration of misonidazole into spontaneous canine tumours.
Topics: Adenocarcinoma; Anesthesia, Intravenous; Animals; Carcinoma, Squamous Cell; Disease Models, Animal; Dog Diseases; Dogs; Female; Fibrosarcoma; Half-Life; Lymphoma, Non-Hodgkin; Male; Mammary Glands, Animal; Meningioma; Misonidazole; Neoplasms; Nitroimidazoles; Osteosarcoma; Pentobarbital | 1979 |
Antibacterial activity of 3-(1-methyl-5-nitro-2-imidazolylmethylideneamino)-2-oxazolidinone.
Topics: Animals; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Disease Models, Animal; Female; Furazolidone; Kidney Diseases; Male; Mice; Mice, Inbred Strains; Nitroimidazoles; Oxazoles; Rats; Rats, Inbred Strains | 1975 |
Chemotherapy of CNS-trypanosomiasis: combination chemotherapy with a 5-nitroimidazole (MK 436), an arsenical (Cymelarsan) and suramin.
Topics: Animals; Arsenicals; Brain Diseases; Disease Models, Animal; Drug Therapy, Combination; Female; Mice; Nitroimidazoles; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 1991 |
Therapeutic action of MK-436 (2,5-nitroimidazole) on Trypanosoma cruzi infections in mice: a parasitological, serological, histopathological, and ultrastructural study.
Topics: Animals; Chagas Cardiomyopathy; Chagas Disease; Disease Models, Animal; Female; Male; Mice; Myocardium; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi | 1987 |
Experimental models for the evaluation of systemic trichomonacides. Models for evaluation of trichomonacides.
Topics: Acetamides; Alkynes; Animals; Antitrichomonal Agents; Disease Models, Animal; Male; Metronidazole; Mice; Nitro Compounds; Nitroimidazoles; Scrotum; Sulfones; Thiazoles; Trichomonas; Trichomonas Infections; Trichomonas vaginalis | 1973 |
Tests in mice on the activity of ronidazole against the causal mycoplasmata of contagious bovine and caprine pleuropneumonia.
Topics: Administration, Oral; Animals; Blood; Carbamates; Cattle; Cattle Diseases; Disease Models, Animal; Female; Goats; Injections, Intraperitoneal; Injections, Subcutaneous; Mice; Mycoplasma; Mycoplasma Infections; Mycoplasma mycoides; Nitroimidazoles; Pleuropneumonia; Water | 1973 |