azomycin has been researched along with Brain Neoplasms in 58 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 40 (68.97) | 18.7374 |
| 1990's | 4 (6.90) | 18.2507 |
| 2000's | 3 (5.17) | 29.6817 |
| 2010's | 10 (17.24) | 24.3611 |
| 2020's | 1 (1.72) | 2.80 |
| Authors | Studies |
|---|---|
| Fukada, J; Hayakawa, N; Hishiki, T; Koike, N; Kota, R; Matsuura, T; Naito, Y; Onishi, N; Sampetrean, O; Saya, H; Shigematsu, N; Suematsu, M | 1 |
| Brenner, A; Caflisch, L; Cavazos, D; Fichtel, L; Floyd, J; Gruslova, A; Hart, CP; Huang, S; Kroll, S; Liu, Y; Lodi, A; Sun, JD; Tiziani, S; Zuniga, R | 1 |
| Bolcaen, J; Boterberg, T; De Meulenaere, V; De Vos, F; Deblaere, K; Descamps, B; Donche, S; Goethals, I; Kalala, JP; Kersemans, K; Van den Broecke, C; Vanhove, C; Verhoeven, J | 1 |
| Beppu, T; Ehara, S; Fujiwara, S; Iwata, R; Kudo, K; Matsuura, H; Ogasawara, K; Sasaki, M; Sasaki, T; Sera, K; Sugai, T; Takai, Y; Terasaki, K; Uesugi, N; Yamada, N | 1 |
| Beppu, T; Ehara, S; Iwata, R; Mtsuura, H; Ogasawara, K; Sasaki, M; Sasaki, T; Saura, H; Takai, Y; Terasaki, K | 1 |
| Azab, AK; Biswas, P; Chavalmane, S; de la Puente, P; Kapoor, V; Luderer, MJ; Marcelo, R; Muz, B; Rogers, B; Thotala, D | 1 |
| Higano, S; Iwata, R; Kanamori, M; Kumabe, T; Saito, R; Shibahara, I; Sonoda, Y; Takai, Y; Takanami, K; Tominaga, T; Watanabe, M | 1 |
| Babaev, AA; Golubiatnikov, GY; Ivanova, IP; Kamensky, VA; Maslennikova, AV; Orlova, AG; Plekhanov, VI; Prianikova, TI; Shakhova, NM; Snopova, LB; Turchin, IV | 1 |
| Delattre, JY; Goldman, S; Petrirena, GJ | 1 |
| Barbier, EL; Bouchet, A; Christen, T; Le Duc, G; Lemasson, B; Maisin, C; Rémy, C; Serduc, R | 1 |
| Hanzawa, H; Hatano, T; Kuge, Y; Kuno, N; Nishijima, K; Sakamoto, T; Tamaki, N; Zhao, S; Zhao, Y | 1 |
| Dethloff, LA; Miller, TJ; Phelka, AD; Philbert, MA; Tjalkens, RB | 1 |
| Baron, JC; Moustafa, RR; Takasawa, M | 1 |
| Fulton, DS; Geggie, PH; Johnson, E; Mielke, B; Moody, J; Muller, PJ; Shin, KH; Tanasichuk, H; Thomas, H; Urtasun, RC | 1 |
| Kärcher, KH; Kogelnik, HD; Stadler, B; Szepesi, T | 1 |
| Handa, H; Oda, Y; Ono, K; Otsuka, S; Suda, K; Takeuchi, J; Yamashita, J; Yumitori, K | 1 |
| Strike, TA; Walker, MD | 1 |
| Carabell, S; Goodman, RL; Nelson, DF; Nelson, JS; Schoenfeld, D; Wasserman, T; Weinstein, AS | 1 |
| Onoyama, Y | 1 |
| Dische, S | 1 |
| Davis, DR; Diener, MD; Gillespie, BW; Nelson, DF; Phillips, TL; Stetz, J; Wasserman, T | 1 |
| Mitsuhashi, N; Mogi, K; Nakajima, N; Niibe, H; Okazaki, A; Saito, K; Sakaino, K; Sudo, H; Suzuki, Y; Yonome, I | 1 |
| Bleehen, NM; Gleave, JR; Grant, RM; Hardy, DG; Holmes, AE; Jones, DH; Roberts, JT; Workman, P | 1 |
| Gi, H; Handa, H; Oda, Y; Ono, K; Otsuka, S; Suda, K; Takeuchi, J; Yamashita, J | 1 |
| Siemann, DW; Wallen, CA; Wheeler, KT; Wolf, KL | 1 |
| Morrissey, S; Siemann, DW; Wheeler, KT; Wolf, K | 1 |
| Ammon, J; Bamberg, M; Calcanis, A; Godehardt, E; Herbst, M; Keim, H; Kleibel, F; Makoski, HB; Potthoff, PC; Sack, H; Schlegel, G; Schnepper, E; Weidtman, V; Zülch, KJ | 1 |
| Ang, KK; Chenal, C; Fauchon, F; Goffin, JC; Horiot, JC; Notter, G; Raps, J; van der Schueren, E; van Glabbeke, M; van Peperzeel, H; Vessière, M | 1 |
| Blasberg, R; Fenstermacher, J; Horowitz, M; Kornblith, P; Molnar, P; Pleasants, R; Strong, J | 1 |
| Bamberg, M; Scherer, E; Streffer, C; Tamulevicius, P | 2 |
| Bleehen, NM; Gleave, JR; Hawkins, TD; Holmes, AE; Lewin, WS; Plowman, PN; Treip, CS; Watson, JV; Wiltshire, CR | 1 |
| Phillips, TL; Stetz, J; Wasserman, TH | 1 |
| Otsuka, S | 1 |
| Bruno, LA; Carabell, SC; Chang, CH; Goodman, RL; Richter, MP; Weiler, CB; Weinstein, AS | 1 |
| Ash, DV; Smith, MR | 1 |
| Bleehen, NM; Wiltshire, CR; Workman, P | 1 |
| Chapman, JD; Golberg, LE; Groshar, D; Hoskinson, M; Mannan, RH; McEwan, AJ; Mercer, JR; Parliament, MB; Urtasun, RC; Wiebe, LI | 1 |
| Bakker, JH; Bernsen, HJ; Boerman, RH; Peters, JP; Rijken, PF; van der Kogel, AJ; Wesseling, P | 1 |
| Bernsen, HJ; Jeuken, JW; Peters, H; Raleigh, JA; Rijken, PF; van der Kogel, AJ; Wesseling, P | 1 |
| Kärcher, KH; Kogelnik, HD; Seitz, W; Szepesi, T | 1 |
| Fowler, JF | 1 |
| Chapman, D; Koziol, D; Partington, J; Rabin, H; Urtasun, RC | 1 |
| Bleehen, NM; Watson, JV; Wiltshire, CR; Workman, P | 1 |
| Ash, DV; Bugden, RD; Smith, MR | 1 |
| Jentzsch, K; Kärcher, KH; Kogelnik, HD; Maida, E; Mamoli, B; Nitsche, V; Wessely, P; Zaunbauer, F | 1 |
| Bleehen, NM; Dale, AD; Flockhart, IR; Little, CJ; Marten, TR; Ruane, RJ; Workman, P | 1 |
| Alexander, E; Buswell, L; Coleman, CN; Hurwitz, SJ; Kramer, RA; Loeffler, JS; Neben, TY; Riese, N; Shargel, L | 1 |
| Wallen, CA; Wheeler, KT; Wong, KH | 1 |
| Bleehen, NM; Freedman, LS; Stenning, SP | 1 |
| Bleehen, NM; Newman, HF; Ward, R; Workman, P | 1 |
| Awschalom, M; Cohen, L; Hendrickson, FR; Kurup, PD; Mansell, J; Nelson, JS; Pajak, TF; Rosenberg, I; Ten Haken, RK | 1 |
| Ganz, JC; Hagen, S; Hatlevoll, R; Kristiansen, K; Lindegaard, KF; Mella, O; Nesbakken, R; Ringkjöb, R; Rosengren, B; Torvik, A | 1 |
| Curry, B; Fulton, D; Geggie, PH; Johnson, E; Mielke, B; Muller, PJ; Shin, KH; Tanasichuk, H; Thomas, H; Urtasun, RC | 1 |
| Bleehen, NM; Roberts, JT; Walton, MI; Workman, P | 1 |
| Bleehen, NM; Roberts, JT | 1 |
| Inoue, H; Koizumi, H; Murata, M; Nakamura, M; Niibe, H; Tamura, M; Yonome, I | 1 |
2 review(s) available for azomycin and Brain Neoplasms
| Article | Year |
|---|---|
Advances in PET imaging of brain tumors: a referring physician's perspective.
Topics: Brain Neoplasms; Carbon Radioisotopes; Dideoxynucleosides; Fluorine Radioisotopes; Glioblastoma; Glioma; Humans; Methionine; Nitroimidazoles; Positron-Emission Tomography; Radiography; Radiopharmaceuticals | 2011 |
Applications of nitroimidazole in vivo hypoxia imaging in ischemic stroke.
Topics: Animals; Brain; Brain Neoplasms; Diagnostic Imaging; Humans; Hypoxia-Ischemia, Brain; Ligands; Models, Animal; Nitroimidazoles; Predictive Value of Tests; Stroke | 2008 |
19 trial(s) available for azomycin and Brain Neoplasms
| Article | Year |
|---|---|
Hypoxia-activated evofosfamide for treatment of recurrent bevacizumab-refractory glioblastoma: a phase I surgical study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Combined Modality Therapy; Drug Resistance, Neoplasm; Female; Follow-Up Studies; Glioblastoma; Humans; Hypoxia; Male; Middle Aged; Neoplasm Recurrence, Local; Nitroimidazoles; Phosphoramide Mustards; Prognosis; Salvage Therapy | 2018 |
Standardized uptake value in high uptake area on positron emission tomography with 18F-FRP170 as a hypoxic cell tracer correlates with intratumoral oxygen pressure in glioblastoma.
Topics: Adult; Aged; Aged, 80 and over; Brain Neoplasms; Cell Hypoxia; Female; Fluorodeoxyglucose F18; Glioblastoma; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Middle Aged; Nitroimidazoles; Oxygen; Positron-Emission Tomography; Pressure | 2014 |
Imaging of hypoxic lesions in patients with gliomas by using positron emission tomography with 1-(2-[18F] fluoro-1-[hydroxymethyl]ethoxy)methyl-2-nitroimidazole, a new 18F-labeled 2-nitroimidazole analog.
Topics: Adult; Aged; Astrocytoma; Biopsy; Brain Neoplasms; Carbon Isotopes; Cell Division; Female; Fluorodeoxyglucose F18; Glioblastoma; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia, Brain; Immunohistochemistry; Magnetic Resonance Imaging; Male; Methionine; Middle Aged; Nitroimidazoles; Oligodendroglioma; Positron-Emission Tomography; Protons; Radiopharmaceuticals | 2010 |
Misonidazole combined with hyperfractionation in the management of malignant glioma.
Topics: Adolescent; Adult; Aged; Astrocytoma; Brain Neoplasms; Clinical Trials as Topic; Glioblastoma; Glioma; Humans; Middle Aged; Misonidazole; Nitroimidazoles; Prospective Studies; Radiation-Sensitizing Agents; Radiotherapy Dosage; Random Allocation | 1984 |
Misonidazole and irradiation in the treatment of high-grade astrocytomas: further report of the Vienna Study Group.
Topics: Brain Neoplasms; Clinical Trials as Topic; Female; Glioblastoma; Humans; Male; Middle Aged; Misonidazole; Nitroimidazoles; Prognosis; Radiation-Sensitizing Agents; Random Allocation | 1984 |
Misonidazole in radiotherapy of supratentorial malignant brain gliomas in adult patients: a randomized double-blind study.
Topics: Adult; Brain Neoplasms; Clinical Trials as Topic; Double-Blind Method; Female; Glioma; Humans; Male; Middle Aged; Misonidazole; Nitroimidazoles; Prognosis; Radiotherapy Dosage; Time Factors | 1983 |
A randomized comparison of misonidazole sensitized radiotherapy plus BCNU and radiotherapy plus BCNU for treatment of malignant glioma after surgery; preliminary results of an RTOG study.
Topics: Adolescent; Adult; Aged; Brain Neoplasms; Carmustine; Clinical Trials as Topic; Drug Administration Schedule; Glioma; Humans; Middle Aged; Misonidazole; Nitroimidazoles; Prospective Studies; Radiation-Sensitizing Agents; Random Allocation | 1983 |
[Clinical trials of hypoxic cell sensitizer misonidazole].
Topics: Brain Neoplasms; Clinical Trials as Topic; Drug Evaluation; Female; Glioma; Head and Neck Neoplasms; Humans; Lung Neoplasms; Male; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Random Allocation; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms | 1983 |
Clinical trials with hypoxic cell sensitizers-the European experience.
Topics: Animals; Brain Neoplasms; Clinical Trials as Topic; Head and Neck Neoplasms; Humans; Methods; Misonidazole; Neoplasms; Nitroimidazoles; Urinary Bladder Neoplasms | 1983 |
Is misonidazole neurotoxicity altered by the use of phenytoin and/or dexamethasone in RTOG 79-18 and RTOG 79-16?
Topics: Brain Neoplasms; Clinical Trials as Topic; Dexamethasone; Female; Glioma; Humans; Male; Middle Aged; Misonidazole; Nervous System Diseases; Nitroimidazoles; Phenytoin; Radiation-Sensitizing Agents | 1984 |
[Postoperative radiotherapy of astrocytomas grade 3 and 4 with the radiosensitizer misonidazole. -End results of a multicentric controlled German study].
Topics: Adolescent; Adult; Aged; Astrocytoma; Brain Neoplasms; Clinical Trials as Topic; Germany, West; Humans; Middle Aged; Misonidazole; Nitroimidazoles; Postoperative Care; Radiotherapy Dosage | 1982 |
Misonidazole as a radiosensitizer in the radiotherapy of glioblastomas and oesophageal cancer. Pharmacokinetic and clinical studies.
Topics: Adult; Aged; Brain Neoplasms; Clinical Trials as Topic; Esophageal Neoplasms; Female; Glioma; Humans; Kinetics; Male; Middle Aged; Misonidazole; Neoplasm Recurrence, Local; Nitroimidazoles | 1981 |
A randomized study of misonidazole and radiotherapy for grade 3 and 4 cerebral astrocytoma.
Topics: Adolescent; Adult; Aged; Astrocytoma; Brain Neoplasms; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Random Allocation | 1981 |
Radiation Therapy Oncology Group clinical trials with misonidazole.
Topics: Brain Neoplasms; Clinical Trials as Topic; Drug Administration Schedule; Glioma; Head and Neck Neoplasms; Humans; Misonidazole; Nausea; Nervous System Diseases; Nitroimidazoles; Radiotherapy Dosage; Random Allocation; Vomiting | 1981 |
Clinical studies with misonidazole.
Topics: Adult; Astrocytoma; Brain Neoplasms; Breast Neoplasms; Humans; Nitroimidazoles; Radiation-Sensitizing Agents; Random Allocation; Time Factors | 1978 |
A randomized study of CCNU with and without benznidazole in the treatment of recurrent grades 3 and 4 astrocytoma. Report to the Medical Research Council by the Brain Tumor Working Party.
Topics: Adolescent; Adult; Brain Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; Double-Blind Method; Female; Glioblastoma; Humans; Lomustine; Male; Middle Aged; Neoplasm Recurrence, Local; Nitroimidazoles; Prognosis; Random Allocation | 1989 |
Combined modality treatment of operated astrocytomas grade 3 and 4. A prospective and randomized study of misonidazole and radiotherapy with two different radiation schedules and subsequent CCNU chemotherapy. Stage II of a prospective multicenter trial of
Topics: Actuarial Analysis; Adult; Aged; Brain Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; Female; Glioblastoma; Humans; Lomustine; Male; Middle Aged; Misonidazole; Nitroimidazoles; Radiotherapy Dosage; Random Allocation; Scandinavian and Nordic Countries; Telencephalon | 1985 |
Multiple daily fractionated radiation therapy and misonidazole in the management of malignant astrocytoma. A preliminary report.
Topics: Adolescent; Adult; Aged; Astrocytoma; Brain Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; Humans; Middle Aged; Misonidazole; Nitroimidazoles; Prospective Studies; Random Allocation; Time Factors | 1985 |
Benznidazole with CCNU: a clinical phase I toxicity study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Blood Cell Count; Brain Neoplasms; Drug Evaluation; Humans; Lomustine; Nitroimidazoles | 1985 |
37 other study(ies) available for azomycin and Brain Neoplasms
| Article | Year |
|---|---|
2-Nitroimidazoles induce mitochondrial stress and ferroptosis in glioma stem cells residing in a hypoxic niche.
Topics: Animals; Brain; Brain Neoplasms; Cell Hypoxia; Cell Proliferation; Female; Ferroptosis; Glioma; Imidazoles; Metabolome; Mice, Inbred C57BL; Mitochondria; Neoplastic Stem Cells; Nitroimidazoles; Radiation-Sensitizing Agents; Stress, Physiological | 2020 |
Technical feasibility of [
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Disease Models, Animal; Feasibility Studies; Female; Glioblastoma; Nitroimidazoles; Positron-Emission Tomography; Radiopharmaceuticals; Radiotherapy Dosage; Radiotherapy, Image-Guided; Rats, Inbred F344; Treatment Outcome; Tumor Burden; Tyrosine | 2019 |
High-uptake areas on positron emission tomography with the hypoxic radiotracer (18)F-FRP170 in glioblastomas include regions retaining proliferative activity under hypoxia.
Topics: Adult; Aged; Brain; Brain Neoplasms; Female; Glioblastoma; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Ki-67 Antigen; Male; Middle Aged; Nitroimidazoles; Positron-Emission Tomography; Radiopharmaceuticals | 2015 |
A Hypoxia-Targeted Boron Neutron Capture Therapy Agent for the Treatment of Glioma.
Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Female; Glioma; Mice; Mice, Nude; Nitroimidazoles; Treatment Outcome | 2016 |
Comparative study of tumor hypoxia by diffuse optical spectroscopy and immunohistochemistry in two tumor models.
Topics: Animals; Biomarkers, Tumor; Brain Neoplasms; Diffusion; Disease Models, Animal; Female; Hemoglobins; Hypoxia; Immunohistochemistry; Lymph Nodes; Male; Medical Oncology; Nitroimidazoles; Optical Devices; Oxygen; Radiation-Sensitizing Agents; Rats; Spectrum Analysis | 2010 |
Evaluation of the relationship between MR estimates of blood oxygen saturation and hypoxia: effect of an antiangiogenic treatment on a gliosarcoma model.
Topics: Analysis of Variance; Angiogenesis Inhibitors; Animals; Benzenesulfonates; Brain Neoplasms; Dextrans; Gliosarcoma; Hypoxia, Brain; Image Processing, Computer-Assisted; Immunohistochemistry; Linear Models; Magnetic Resonance Imaging; Magnetite Nanoparticles; Male; Niacinamide; Nitroimidazoles; Oxygen; Phenylurea Compounds; Pyridines; Random Allocation; Rats; Rats, Inbred F344; Reproducibility of Results; Sorafenib | 2012 |
Biological characteristics of intratumoral [F-18]‑fluoromisonidazole distribution in a rodent model of glioma.
Topics: Animals; Autoradiography; Biological Transport; Brain Neoplasms; Cell Hypoxia; Cell Proliferation; Fluorodeoxyglucose F18; Glioma; Glucose; Glucose Transporter Type 1; Hexokinase; Hypoxia-Inducible Factor 1; Ki-67 Antigen; Male; Misonidazole; Nitroimidazoles; Rats; Rats, Wistar; Tissue Distribution | 2013 |
CI-1010 induced opening of the mitochondrial permeability transition pore precedes oxidative stress and apoptosis in SY5Y neuroblastoma cells.
Topics: Antioxidants; Apoptosis; Brain Neoplasms; Cell Death; Cell Survival; DNA Fragmentation; Flow Cytometry; Humans; In Situ Nick-End Labeling; Membrane Potentials; Microscopy, Electron; Mitochondria; Neuroblastoma; Nitroimidazoles; Oxidative Stress; Permeability; Photoreceptor Cells; Radiation-Sensitizing Agents; Reactive Oxygen Species; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured; Vitamin E | 2003 |
[Radiosensitizing effect of misonidazole on intracranially transplanted tumors in mice and its clinical application (author's transl)].
Topics: Adult; Aged; Animals; Brain Neoplasms; Cobalt Radioisotopes; Female; Glioma; Humans; Male; Mice; Mice, Inbred C57BL; Middle Aged; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents; Radiotherapy Dosage | 1982 |
Misonidazole peripheral neuropathy: its relationship to plasma concentration and other drugs.
Topics: Adrenal Cortex Hormones; Barbiturates; Brain Neoplasms; Drug Interactions; Female; Glioma; Half-Life; Humans; Male; Middle Aged; Misonidazole; Nitroimidazoles; Peripheral Nervous System Diseases; Phenytoin | 1980 |
[Clinical evaluation of radiosensitizing effects of misonidazole].
Topics: Brain Neoplasms; Combined Modality Therapy; Drug Evaluation; Esophageal Neoplasms; Humans; Lung Neoplasms; Misonidazole; Nitroimidazoles | 1984 |
The penetration of misonidazole and desmethylmisonidazole into brain tumours and other central nervous system tissues in man.
Topics: Adolescent; Adult; Aged; Brain; Brain Neoplasms; Female; Humans; Male; Middle Aged; Misonidazole; Nitroimidazoles; Time Factors | 1983 |
[Local administration of radiosensitizer misonidazole].
Topics: Adult; Aged; Animals; Astrocytoma; Brain Neoplasms; Dogs; Drug Implants; Female; Glioma; Humans; Injections, Spinal; Kinetics; Male; Mice; Mice, Inbred C57BL; Misonidazole; Nitroimidazoles; Rats; Silicone Elastomers; Uterine Neoplasms | 1983 |
Hypoxic cells and in situ chemopotentiation of the nitrosoureas by misonidazole.
Topics: Animals; Brain Neoplasms; Carmustine; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Lomustine; Misonidazole; Nitroimidazoles; Oxygen; Rats; Skin Neoplasms; Tumor Stem Cell Assay | 1984 |
In vitro potentiation of BCNU activity in rat brain tumour cells pretreated with misonidazole.
Topics: Animals; Brain Neoplasms; Carmustine; Cell Survival; Cells, Cultured; Drug Synergism; Misonidazole; Nitroimidazoles; Rats | 1984 |
Split course multiple daily fractionated radiotherapy schedule combined with misonidazole for the management of grade III and IV gliomas. A pilot feasibility study of the Radiotherapy Group of the EORTC.
Topics: Adolescent; Adult; Aged; Brain Neoplasms; Child; Female; Glioma; Humans; Male; Middle Aged; Misonidazole; Nitroimidazoles; Pilot Projects; Prognosis; Radiotherapy Dosage; Radiotherapy, High-Energy | 1982 |
Regional [14C]misonidazole distribution in experimental RT-9 brain tumors.
Topics: Animals; Autoradiography; Brain Neoplasms; Cerebrovascular Circulation; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Rats; Rats, Inbred F344; Regional Blood Flow; Tissue Distribution | 1983 |
[Radiosensitizing effect of misonidazole in radiotherapy for intracranial tumors].
Topics: Adolescent; Adult; Aged; Animals; Brain Neoplasms; Child; Drug Implants; Female; Glioma; Humans; Male; Mice; Middle Aged; Misonidazole; Nitroimidazoles; Silicone Elastomers | 1982 |
Misonidazole and radiotherapy to treat malignant glioma: a phase II trial of the radiation therapy oncology group.
Topics: Astrocytoma; Brain Neoplasms; Drug Evaluation; Glioma; Humans; Misonidazole; Nitroimidazoles; Prognosis | 1981 |
[Clinical experiences with the radiosensitizer Misonidazol (author's transl)].
Topics: Adolescent; Adult; Aged; Brain Neoplasms; Dexamethasone; Drug Interactions; Esophageal Neoplasms; Exanthema; Female; Glioma; Half-Life; Humans; Male; Middle Aged; Misonidazole; Neoplasm Recurrence, Local; Nitroimidazoles; Phenytoin | 1981 |
Causes of apparent low levels of misonidazole in human tumours.
Topics: Adipose Tissue; Animals; Brain Neoplasms; Humans; In Vitro Techniques; Liver Neoplasms; Mammary Neoplasms, Experimental; Mice; Misonidazole; Muscles; Neoplasms; Nitroimidazoles; Rats | 1980 |
Phenytoin shortens the half-life of the hypoxic cell radiosensitizer misonidazole in man: implications for possible reduced toxicity.
Topics: Brain Neoplasms; Half-Life; Humans; Kinetics; Misonidazole; Nitroimidazoles; Phenytoin | 1980 |
Imaging tumor hypoxia and tumor perfusion.
Topics: Brain Neoplasms; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Cell Hypoxia; Female; Glioblastoma; Head and Neck Neoplasms; Humans; Iodine Radioisotopes; Lung Neoplasms; Male; Nitroimidazoles; Organotechnetium Compounds; Oximes; Sarcoma; Soft Tissue Neoplasms; Technetium Tc 99m Exametazime; Tomography, Emission-Computed, Single-Photon | 1993 |
Suramin treatment of human glioma xenografts; effects on tumor vasculature and oxygenation status.
Topics: Animals; Antineoplastic Agents; Blood Vessels; Brain Neoplasms; Glioma; Humans; Hypoxia; Mice; Mice, Nude; Neoplasm Transplantation; Nitroimidazoles; Oxygen Consumption; Staining and Labeling; Suramin; Transplantation, Heterologous | 1999 |
Hypoxia in a human intracerebral glioma model.
Topics: Animals; Brain Neoplasms; Cell Division; Disease Models, Animal; Glioma; Hypoxia; Mice; Mice, Inbred BALB C; Microcirculation; Nitroimidazoles; Radiation-Sensitizing Agents | 2000 |
[Clinical experiences with the radiation-sensitizing agent misonidazole].
Topics: Brain Neoplasms; Cardiovascular System; Central Nervous System; Digestive System; Drug Eruptions; Eye; Female; Humans; Liver; Male; Misonidazole; Neoplasms; Nitroimidazoles | 1978 |
Developments in radiotherapy other than heavy particle beams.
Topics: Animals; Brain Neoplasms; Energy Transfer; Fast Neutrons; Female; Glioblastoma; Hot Temperature; Humans; Mammary Neoplasms, Experimental; Metronidazole; Mice; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents; Radiotherapy Dosage; Radiotherapy, High-Energy; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; X-Rays | 1977 |
New side effect of the hypoxic cell sensitizer, misonidazole.
Topics: Aged; Brain Neoplasms; Drug Eruptions; Drug Therapy, Combination; Female; Glioblastoma; Humans; Male; Misonidazole; Nitroimidazoles | 1979 |
Distribution of misonidazole in human tumours and normal tissues.
Topics: Brain Neoplasms; Breast Neoplasms; Female; Genital Neoplasms, Female; Humans; Male; Misonidazole; Neoplasms; Nitroimidazoles; Thyroid Diseases; Tissue Distribution; Urinary Bladder Neoplasms | 1979 |
Initial clinical experience with the radiosensitizing nitroimidazole Ro 07-0582.
Topics: Adolescent; Adult; Aged; Brain Neoplasms; Humans; Middle Aged; Nervous System Diseases; Nitroimidazoles; Radiation-Sensitizing Agents | 1977 |
Estimation of the hypoxic cell-sensitiser misonidazole and its O-demethylated metabolite in biological materials by reversed-phase high-performance liquid chromatography.
Topics: Brain Neoplasms; Chromatography, High Pressure Liquid; Glioma; Humans; Nitroimidazoles; Radiation-Sensitizing Agents | 1978 |
Distribution of etanidazole into human brain tumors: implications for treating high grade gliomas.
Topics: Brain Neoplasms; Combined Modality Therapy; Drug Evaluation; Etanidazole; Humans; Infusions, Intravenous; Nitroimidazoles; Radiation-Sensitizing Agents; Time Factors | 1992 |
2-Nitroimidazole potentiation of nitrosourea induced cytotoxicity in subcutaneous implants of rat 9L brain tumor cells.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Cell Line; Cell Survival; Drug Synergism; Etanidazole; Lomustine; Male; Misonidazole; Nitroimidazoles; Rats; Rats, Inbred F344; Streptozocin; Tumor Stem Cell Assay | 1991 |
Hypoxic cell radiosensitizers in the treatment of high grade gliomas: a new direction using combined Ro 03-8799 (pimonidazole) and SR 2508 (etanidazole).
Topics: Brain Neoplasms; Drug Therapy, Combination; Etanidazole; Glioblastoma; Humans; Nitroimidazoles; Radiation-Sensitizing Agents | 1988 |
Fast neutrons and misonidazole for malignant astrocytomas.
Topics: Adult; Aged; Astrocytoma; Brain Neoplasms; Combined Modality Therapy; Female; Glioblastoma; Humans; Male; Middle Aged; Misonidazole; Neutrons; Nitroimidazoles | 1985 |
A clinical phase I toxicity study of Ro 03-8799: plasma, urine, tumour and normal brain pharmacokinetics.
Topics: Astrocytoma; Brain; Brain Diseases; Brain Neoplasms; Dose-Response Relationship, Drug; Drug Evaluation; Humans; Kinetics; Neoplasms; Nitroimidazoles | 1986 |
Radiation therapy of rat brain tumor using misonidazole as hypoxic cell sensitizer.
Topics: Animals; Brain Neoplasms; Dose-Response Relationship, Radiation; Glioma; Misonidazole; Nitroimidazoles; Oxygen; Rats | 1985 |