azlocillin and Burns

Pharmacokinetic values of azlocillin were determined in burned patients during the exudation and repair periods. A single dose of 80 mg/kg was administered intravenously over 30 min. Pharmacokinetic constants were calculated using an open two-compartment model. During the exudation period the ultimate serum half-lives (t 1/2 beta) were 1.17 to 1.4 h, 1.73 to 1.78 h and 3.3 h respectively with creatinine clearances of 111-131, 60-94 and 14 ml/min/1.73 m2. Renal clearances varied from 30.9 to 128 ml/min/1.73 m2. During the repair period little change was observed in t 1/2 beta, but renal clearance increased from 36.6 to 116 ml/min/1.73 m2 in one patient. It is concluded that azlocillin behaves in burned patients as in patients with impaired renal function.

Topics: Adult; Aged; Azlocillin; Burns; Exudates and Transudates; Humans; Kidney; Kinetics; Middle Aged; Penicillins; Time Factors; Wound Healing