azinomycin-b and Breast-Neoplasms

azinomycin-b has been researched along with Breast-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for azinomycin-b and Breast-Neoplasms

Article	Year
Role of the azinomycin naphthoate and central amide in sequence-dependent DNA alkylation and cytotoxicity of epoxide-bearing substructures. Organic letters, 2002, Oct-03, Volume: 4, Issue:20 Studies report a strong correlation between duplex DNA alkylation and in vitro cytotoxicity for a series of azinomycin partial structures 2-6 bearing the biologically relevant epoxide. Compounds lacking the naphthoate ester (e.g., 5 and 6) were poorly reactive toward DNA and were biologically inactive, as were compounds bearing the naphthoate but lacking the terminal carboxamide (e.g., 2). Compounds were evaluated for cytotoxicity against two breast cancer cell lines. [structure: see text] Topics: Alkylation; Anti-Bacterial Agents; Antineoplastic Agents; Azabicyclo Compounds; Base Sequence; Breast Neoplasms; Cell Division; Cross-Linking Reagents; Dipeptides; DNA; DNA Adducts; Epoxy Compounds; Glycopeptides; Humans; Intercellular Signaling Peptides and Proteins; Naphthalenes; Peptides; Tumor Cells, Cultured	2002

Article

Year

Role of the azinomycin naphthoate and central amide in sequence-dependent DNA alkylation and cytotoxicity of epoxide-bearing substructures.

Organic letters, 2002, Oct-03, Volume: 4, Issue:20

Studies report a strong correlation between duplex DNA alkylation and in vitro cytotoxicity for a series of azinomycin partial structures 2-6 bearing the biologically relevant epoxide. Compounds lacking the naphthoate ester (e.g., 5 and 6) were poorly reactive toward DNA and were biologically inactive, as were compounds bearing the naphthoate but lacking the terminal carboxamide (e.g., 2). Compounds were evaluated for cytotoxicity against two breast cancer cell lines. [structure: see text]

Topics: Alkylation; Anti-Bacterial Agents; Antineoplastic Agents; Azabicyclo Compounds; Base Sequence; Breast Neoplasms; Cell Division; Cross-Linking Reagents; Dipeptides; DNA; DNA Adducts; Epoxy Compounds; Glycopeptides; Humans; Intercellular Signaling Peptides and Proteins; Naphthalenes; Peptides; Tumor Cells, Cultured

2002