azidopine and Cardiomyopathies

azidopine has been researched along with Cardiomyopathies* in 1 studies

Other Studies

1 other study(ies) available for azidopine and Cardiomyopathies

Article	Year
Photoaffinity labeling of the calcium channel antagonist receptor in the heart of the cardiomyopathic hamster. Biochemical and biophysical research communications, 1987, Nov-13, Volume: 148, Issue:3 The high affinity 1,4-dihydropyridine receptors of the cardiac membrane calcium channel from Syrian Cardiomyopathic hamsters were studied using [3H] PN200-110 and [3H]azidopine as ligands. [3H]Azidopine was photoincorporated covalently into bands of 180, 100, 79, 45 and 31 kDa, as determined by SDS/polyacrylamide gel electrophoresis. Photolabeling of the 180 kDa band is protected by 2 microM [1H]PN200-110 whereas the lower Mr bands are not. Thus, only the 180 kDa band is the calcium channel linked 1,4 dihydropyridine receptor. The photoincorporation into this 180 kDa band is doubled with samples of myopathic hamsters vs. control hamsters. It is suggested that the increase in calcium channel receptors may be involved in the pathogenesis of this cardiomyopathy. Topics: Affinity Labels; Animals; Azides; Calcium; Calcium Channel Blockers; Calcium Channels; Cardiomyopathies; Cricetinae; Dihydropyridines; In Vitro Techniques; Ion Channels; Isradipine; Membrane Proteins; Molecular Weight; Myocardium; Oxadiazoles; Receptors, Nicotinic; Sarcolemma	1987

Article

Year

Photoaffinity labeling of the calcium channel antagonist receptor in the heart of the cardiomyopathic hamster.

Biochemical and biophysical research communications, 1987, Nov-13, Volume: 148, Issue:3

The high affinity 1,4-dihydropyridine receptors of the cardiac membrane calcium channel from Syrian Cardiomyopathic hamsters were studied using [3H] PN200-110 and [3H]azidopine as ligands. [3H]Azidopine was photoincorporated covalently into bands of 180, 100, 79, 45 and 31 kDa, as determined by SDS/polyacrylamide gel electrophoresis. Photolabeling of the 180 kDa band is protected by 2 microM [1H]PN200-110 whereas the lower Mr bands are not. Thus, only the 180 kDa band is the calcium channel linked 1,4 dihydropyridine receptor. The photoincorporation into this 180 kDa band is doubled with samples of myopathic hamsters vs. control hamsters. It is suggested that the increase in calcium channel receptors may be involved in the pathogenesis of this cardiomyopathy.

Topics: Affinity Labels; Animals; Azides; Calcium; Calcium Channel Blockers; Calcium Channels; Cardiomyopathies; Cricetinae; Dihydropyridines; In Vitro Techniques; Ion Channels; Isradipine; Membrane Proteins; Molecular Weight; Myocardium; Oxadiazoles; Receptors, Nicotinic; Sarcolemma

1987