azepexole has been researched along with Muscle Contraction in 17 studies
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| ") caused a 20-30 fold rightward displacement of the dose-response curve to xylazine, but did not affect responses to B-HT933." | 1.28 | Alpha 2-adrenoceptor blocking profile of SK&F 104078: further evidence for receptor subtypes. ( Akers, I; Coates, J; Drew, GM; Sullivan, AT, 1991) |
| " Prazosin (a preferential alpha 1-antagonist) inhibited the dose-response curves to noradrenaline and phenylephrine 100 and 1000-times respectively more effectively than either phentolamine or rauwolscine (a preferential alpha 2-antagonist)." | 1.27 | Pharmacological characterization of alpha-adrenoreceptor subtypes in rat isolated thoracic aorta. ( Charlton, KG; Clarke, DE; Hamed, AT; Johnson, TD, 1983) |
| "(-) Idazoxan was selective for postsynaptic alpha 2-adrenoceptors and antagonized presynaptic alpha 2-adrenoceptors of the rat." | 1.27 | (Imidazolinyl-2)-2-benzodioxane 1-4 (idazoxan) and its stereoisomers, new alpha 2-antagonists. ( Dabiré, H; Mouille, P; Schmitt, H, 1985) |
| "Yohimbine was also more potent than the synthetic antagonists in blocking the B-HT 933-induced contractile responses of the dog saphenous vein and preventing adrenaline-induced aggregation of human platelets." | 1.27 | Studies of alpha 2-adrenoceptor antagonist potency in vitro: comparisons in tissues from rats, rabbits, dogs and humans. ( Lattimer, N; Rhodes, KF; Waterfall, JF, 1985) |
| " B-HT 933 did not affect the cumulative dose-response curves of the vas deferens and of MP-LM to noradrenaline (NA) and acetylcholine (Ach) respectively." | 1.27 | Mechanism of action of B-HT 933 (azepexole) in rat vas deferens and guinea-pig ileum. ( Brugger, AJ; Vargas, ML, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (47.06) | 18.7374 |
| 1990's | 9 (52.94) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ruffolo, RR | 1 |
| Morgan, EL | 1 |
| Messick, K | 1 |
| Joly, G | 1 |
| Mouillé, P | 2 |
| Dabiré, H | 2 |
| Lucet, B | 1 |
| Schmitt, H | 2 |
| Hamed, AT | 1 |
| Johnson, TD | 1 |
| Charlton, KG | 1 |
| Clarke, DE | 1 |
| Ishii, K | 1 |
| Yamamoto, S | 1 |
| Kato, R | 1 |
| Ito, M | 1 |
| Naruse, A | 1 |
| Yamamoto, I | 1 |
| Oguri, M | 1 |
| Suzuki, Y | 1 |
| Satake, N | 1 |
| Shibata, S | 1 |
| Kurvers, H | 1 |
| Daemen, M | 1 |
| Slaaf, D | 1 |
| Stassen, F | 1 |
| van den Wildenberg, F | 1 |
| Kitslaar, P | 1 |
| de Mey, J | 1 |
| Nielsen, H | 2 |
| Mortensen, FV | 2 |
| Pilegaard, HK | 1 |
| Hasenkam, JM | 1 |
| Mulvany, MJ | 2 |
| Akers, I | 1 |
| Coates, J | 1 |
| Drew, GM | 1 |
| Sullivan, AT | 1 |
| Langer, SZ | 1 |
| Angel, I | 1 |
| Sánchez, J | 1 |
| Costa, G | 1 |
| Benedito, S | 1 |
| Rivera, L | 1 |
| García-Sacristán, A | 1 |
| Orensanz, LM | 1 |
| Nyborg, NC | 1 |
| Pagenkopf, CW | 1 |
| Bourreau, JP | 1 |
| Challice, CE | 1 |
| Waterfall, JF | 2 |
| Rhodes, KF | 2 |
| Lattimer, N | 1 |
| Vargas, ML | 1 |
| Brugger, AJ | 1 |
17 other studies available for azepexole and Muscle Contraction
| Article | Year |
|---|---|
Possible relationship between receptor reserve and the differential antagonism of alpha-1 and alpha-2 adrenoceptor-mediated pressor responses by calcium channel antagonists in the pithed rat.
Topics: Animals; Aorta, Thoracic; Azepines; Blood Pressure; Decerebrate State; Diltiazem; Dose-Response Rela | 1984 |
Pre- and postsynaptic alpha-adrenoceptor blocking properties of a new dihydrobenzofurane derivative (imidazolinyl-2)-2-dihydro 2,3 benzofurane (S 9871) and its stereoisomers in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Azepines; Benzofurans; Blood Pressure; Clonidine; Drug Intera | 1984 |
Pharmacological characterization of alpha-adrenoreceptor subtypes in rat isolated thoracic aorta.
Topics: Animals; Aorta, Thoracic; Azepines; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, V | 1983 |
Development of clonidine-tolerance in the rat vas deferens: cross tolerance to other presynaptic inhibitory agents.
Topics: Adenosine; Animals; Azepines; Clonidine; Drug Tolerance; Endorphins; Evoked Potentials; Male; Methox | 1982 |
Nephrosis augments contractile response to adrenoceptor agonists by the decrease in release of endothelium-derived relaxing factor from the endothelial cells.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adrenergic alpha-Agonists; Anima | 1994 |
Partial peripheral neuropathy and denervation induced adrenoceptor supersensitivity. Functional studies in an experimental model.
Topics: Adrenergic alpha-Agonists; Adrenergic Fibers; Animals; Arteries; Azepines; Catecholamines; Denervati | 1998 |
Calcium utilization coupled to stimulation of postjunctional alpha-1 and alpha-2 adrenoceptors in isolated human resistance arteries.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Arteries; Azepines; Calcium; Female; Humans; In Vitro Tec | 1992 |
Alpha 2-adrenoceptor blocking profile of SK&F 104078: further evidence for receptor subtypes.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Azepines; Benzaze | 1991 |
Pre- and postsynaptic alpha-2 adrenoceptors as target for drug discovery.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Azepines; Dioxanes; Dogs; Hypergly | 1991 |
Alpha 2-mediated effect of dopamine on the motility of the chicken esophagus.
Topics: Adrenergic alpha-Agonists; Animals; Apomorphine; Azepines; Chickens; Dopamine; Esophagus; Gastrointe | 1990 |
Responses to noradrenaline in human subcutaneous resistance arteries are mediated by both alpha 1- and alpha 2-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Aged; Arteries; Azepines; Female; Hu | 1990 |
Action of noradrenaline on isolated proximal and distal coronary arteries of rat: selective release of endothelium-derived relaxing factor in proximal arteries.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Animals; Arteries; Azepines; Coronary Vessels; Dinoprost; | 1990 |
Changes in prejunctional potency of B-HT 933 during aging in the rat vas deferens.
Topics: Aging; Animals; Azepines; Male; Muscle Contraction; Rats; Rats, Inbred Strains; Receptors, Adrenergi | 1990 |
(Imidazolinyl-2)-2-benzodioxane 1-4 (idazoxan) and its stereoisomers, new alpha 2-antagonists.
Topics: Animals; Azepines; Chickens; Clonidine; Dioxanes; Dioxins; Heart Rate; Idazoxan; Imidazoles; Male; M | 1985 |
Studies of alpha 2-adrenoceptor antagonist potency in vitro: comparisons in tissues from rats, rabbits, dogs and humans.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Azepines; Clonidine; Dioxanes; Dog | 1985 |
The effects of some alpha-adrenoceptor antagonists on the responses of the canine saphenous vein to B-HT 933, UK-14304 and methoxamine.
Topics: Adrenergic alpha-Antagonists; Animals; Azepines; Brimonidine Tartrate; Dioxanes; Dogs; Idazoxan; In | 1987 |
Mechanism of action of B-HT 933 (azepexole) in rat vas deferens and guinea-pig ileum.
Topics: Acetylcholine; Animals; Azepines; Dose-Response Relationship, Drug; Female; Guinea Pigs; Ileum; In V | 1985 |