Page last updated: 2024-10-23

azelastine and Rhinitis

azelastine has been researched along with Rhinitis in 14 studies

azelastine: azeptin is azelastine hydrochloride; structure; eye drop formulation effective in relieving symptoms of allergic conjunctivitis; do not confuse with 5-loxin which is an extract of Boswellia
azelastine : A phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position.

Rhinitis: Inflammation of the NASAL MUCOSA, the mucous membrane lining the NASAL CAVITIES.

Research Excerpts

ExcerptRelevanceReference
"We recruited 24 subjects with perennial allergic rhinitis and randomized them in a double-blinded, crossover fashion, to receive placebo or azelastine two sprays BID, using Balaam's design."9.09Effect of topical nasal azelastine on the symptoms of rhinitis, sleep, and daytime somnolence in perennial allergic rhinitis. ( Berlin, JM; Chinchilli, V; Craig, TJ; Golden, S; Kakumanu, S; Lehman, EB; Lucus, T; Mauger, EA; Teets, SJ, 2000)
"05% azelastine eye drops twice daily administered for 14 days to patients with seasonal allergic conjunctivitis or rhinoconjunctivitis."9.08Double-blind, randomised, placebo-controlled study of two concentrations of azelastine eye drops in seasonal allergic conjunctivitis or rhinoconjunctivitis. ( Lenhard, G; Mivsek-Music, E; Obtulowicz, K; Perrin-Fayolle, M; Secchi, A, 1997)
"The study was carried out to investigate the effect of azelastine on the Substance P (SP) concentration in bronchoalveolar (BAL) and nasal (NAL) lavage obtained from atopic grass pollen asthmatics and non-atopic healthy subjects."9.07Effect of azelastine on substance P content in bronchoalveolar and nasal lavage fluids of patients with allergic asthma. ( Baumgarten, C; Furkert, J; Kunkel, G; Laake, E; Müller, S; Nieber, K; Rathsack, R, 1993)
"Azelastine is a potent H(1)-antihistamine, which is available as a topical nasal spray and indicated for both seasonal allergic and non-allergic vasomotor rhinitis."8.84Review of azelastine nasal spray in the treatment of allergic and non-allergic rhinitis. ( Corren, J; Lee, C, 2007)
"Azelastine hydrochloride (azelastine) nasal spray is a histamine receptor-1 (H1) antagonist often used in treating allergic rhinitis to relieve its symptoms."7.91Azelastine nasal spray inhibiting sympathetic function on human nasal mucosa in patients with allergy rhinitis. ( Cheng, LH; Chu, YH; Lee, JC; Lin, YY; Wang, HW; Wu, PC, 2019)
"Nonallergic rhinitis patients exhibited increased blood flow to several regions of the brain in response to both pleasant and unpleasant odorants, specifically in odor-sensitive regions, while off intranasal azelastine."7.77Alteration of brain activation patterns in nonallergic rhinitis patients using functional magnetic resonance imaging before and after treatment with intranasal azelastine. ( Allendorfer, JB; Bernstein, JA; Boespflug, EL; Eliassen, JC; Hastings, L; Lamy, M, 2011)
"To determine if greater efficacy could be achieved with the intranasal antihistamine azelastine and the intranasal corticosteroid fluticasone propionate used concurrently in the treatment of nasal obstruction of persistent non-allergic rhinitis."5.20[Clinical study of the combination therapy with intranasal antihistamine and nasal corticosteroids in the treatment of nasal obstruction of persistent non-allergic rhinitis]. ( Guo, L; Liu, J; Sun, X; Wang, D; Yang, J, 2015)
"We recruited 24 subjects with perennial allergic rhinitis and randomized them in a double-blinded, crossover fashion, to receive placebo or azelastine two sprays BID, using Balaam's design."5.09Effect of topical nasal azelastine on the symptoms of rhinitis, sleep, and daytime somnolence in perennial allergic rhinitis. ( Berlin, JM; Chinchilli, V; Craig, TJ; Golden, S; Kakumanu, S; Lehman, EB; Lucus, T; Mauger, EA; Teets, SJ, 2000)
"05% azelastine eye drops twice daily administered for 14 days to patients with seasonal allergic conjunctivitis or rhinoconjunctivitis."5.08Double-blind, randomised, placebo-controlled study of two concentrations of azelastine eye drops in seasonal allergic conjunctivitis or rhinoconjunctivitis. ( Lenhard, G; Mivsek-Music, E; Obtulowicz, K; Perrin-Fayolle, M; Secchi, A, 1997)
"The study was carried out to investigate the effect of azelastine on the Substance P (SP) concentration in bronchoalveolar (BAL) and nasal (NAL) lavage obtained from atopic grass pollen asthmatics and non-atopic healthy subjects."5.07Effect of azelastine on substance P content in bronchoalveolar and nasal lavage fluids of patients with allergic asthma. ( Baumgarten, C; Furkert, J; Kunkel, G; Laake, E; Müller, S; Nieber, K; Rathsack, R, 1993)
"Azelastine is a potent H(1)-antihistamine, which is available as a topical nasal spray and indicated for both seasonal allergic and non-allergic vasomotor rhinitis."4.84Review of azelastine nasal spray in the treatment of allergic and non-allergic rhinitis. ( Corren, J; Lee, C, 2007)
"To review existing treatments for rhinitis and summarize data available on the use of a nasal antihistamine (azelastine) in treating allergic and nonallergic vasomotor rhinitis."4.84A novel and effective approach to treating rhinitis with nasal antihistamines. ( Kaliner, MA, 2007)
"Azelastine hydrochloride (azelastine) nasal spray is a histamine receptor-1 (H1) antagonist often used in treating allergic rhinitis to relieve its symptoms."3.91Azelastine nasal spray inhibiting sympathetic function on human nasal mucosa in patients with allergy rhinitis. ( Cheng, LH; Chu, YH; Lee, JC; Lin, YY; Wang, HW; Wu, PC, 2019)
"Nonallergic rhinitis patients exhibited increased blood flow to several regions of the brain in response to both pleasant and unpleasant odorants, specifically in odor-sensitive regions, while off intranasal azelastine."3.77Alteration of brain activation patterns in nonallergic rhinitis patients using functional magnetic resonance imaging before and after treatment with intranasal azelastine. ( Allendorfer, JB; Bernstein, JA; Boespflug, EL; Eliassen, JC; Hastings, L; Lamy, M, 2011)
"Rhinitis is a common condition that affects a significant proportion of the general population, as well as a high proportion of athletes."2.43Nasal obstruction, the airway, and the athlete. ( Craig, TJ; Davies, MJ; Fisher, LH, 2005)
"Nonallergic rhinitis is a common disease that probably affects as many as 17 million Americans."2.41Update on nonallergic rhinitis. ( Lieberman, P; Settipane, RA, 2001)
"Rhinosinusitis was assessed by questionnaires, direct examination of the nose and by high-resolution computed tomography."1.35Postnasal drip and chronic cough: An open interventional study. ( Arbery, J; Chung, KF; Durham, SR; Macedo, P; MacKay, I; Saleh, H; Torrego, A, 2009)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (14.29)18.2507
2000's7 (50.00)29.6817
2010's5 (35.71)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Procopiou, PA1
Browning, C1
Buckley, JM1
Clark, KL1
Fechner, L1
Gore, PM1
Hancock, AP1
Hodgson, ST1
Holmes, DS1
Kranz, M1
Looker, BE1
Morriss, KM1
Parton, DL1
Russell, LJ1
Slack, RJ1
Sollis, SL1
Vile, S1
Watts, CJ1
Cheng, LH1
Lee, JC1
Wu, PC1
Lin, YY1
Chu, YH1
Wang, HW1
Guo, L1
Sun, X1
Yang, J1
Liu, J1
Wang, D1
Daramola, OO1
Kern, RC1
Macedo, P1
Saleh, H1
Torrego, A1
Arbery, J1
MacKay, I1
Durham, SR1
Chung, KF1
Bernstein, JA1
Hastings, L1
Boespflug, EL1
Allendorfer, JB1
Lamy, M1
Eliassen, JC1
Fisher, LH1
Davies, MJ1
Craig, TJ2
Lee, C1
Corren, J1
Kaliner, MA1
Nieber, K1
Baumgarten, C1
Rathsack, R1
Furkert, J1
Laake, E1
Müller, S1
Kunkel, G1
Lenhard, G1
Mivsek-Music, E1
Perrin-Fayolle, M1
Obtulowicz, K1
Secchi, A1
Golden, S1
Teets, SJ1
Lehman, EB1
Mauger, EA1
Chinchilli, V1
Berlin, JM1
Kakumanu, S1
Lucus, T1
Stone, BD1
Settipane, RA1
Lieberman, P1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Role of the Nose for Physical Capacity[NCT04712799]Phase 467 participants (Anticipated)Interventional2021-01-13Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for azelastine and Rhinitis

ArticleYear
An update regarding the treatment of nonallergic rhinitis.
    Current opinion in otolaryngology & head and neck surgery, 2016, Volume: 24, Issue:1

    Topics: Administration, Intranasal; Adrenal Cortex Hormones; Beclomethasone; Capsaicin; Drug Therapy, Combin

2016
Nasal obstruction, the airway, and the athlete.
    Clinical reviews in allergy & immunology, 2005, Volume: 29, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Asthma; Nasal Obstruction; Phthalazines; Respiratory System

2005
Review of azelastine nasal spray in the treatment of allergic and non-allergic rhinitis.
    Expert opinion on pharmacotherapy, 2007, Volume: 8, Issue:5

    Topics: Administration, Intranasal; Animals; Anti-Allergic Agents; Biological Availability; Humans; Phthalaz

2007
A novel and effective approach to treating rhinitis with nasal antihistamines.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2007, Volume: 99, Issue:5

    Topics: Administration, Intranasal; Adrenal Cortex Hormones; Drug Therapy, Combination; Histamine H1 Antagon

2007
Update on nonallergic rhinitis.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2001, Volume: 86, Issue:5

    Topics: Adrenal Cortex Hormones; Adult; Age of Onset; Air Pollution; Anti-Inflammatory Agents, Non-Steroidal

2001

Trials

4 trials available for azelastine and Rhinitis

ArticleYear
[Clinical study of the combination therapy with intranasal antihistamine and nasal corticosteroids in the treatment of nasal obstruction of persistent non-allergic rhinitis].
    Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery, 2015, Volume: 29, Issue:3

    Topics: Administration, Intranasal; Adrenal Cortex Hormones; Drug Therapy, Combination; Histamine H1 Antagon

2015
Effect of azelastine on substance P content in bronchoalveolar and nasal lavage fluids of patients with allergic asthma.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1993, Volume: 23, Issue:1

    Topics: Adolescent; Adult; Asthma; Bronchoalveolar Lavage Fluid; Exudates and Transudates; Female; Histamine

1993
Double-blind, randomised, placebo-controlled study of two concentrations of azelastine eye drops in seasonal allergic conjunctivitis or rhinoconjunctivitis.
    Current medical research and opinion, 1997, Volume: 14, Issue:1

    Topics: Adolescent; Adult; Aged; Anti-Allergic Agents; Conjunctivitis, Allergic; Dermatitis, Irritant; Doubl

1997
Effect of topical nasal azelastine on the symptoms of rhinitis, sleep, and daytime somnolence in perennial allergic rhinitis.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2000, Volume: 85, Issue:1

    Topics: Administration, Topical; Adolescent; Adult; Circadian Rhythm; Cross-Over Studies; Double-Blind Metho

2000

Other Studies

5 other studies available for azelastine and Rhinitis

ArticleYear
The discovery of phthalazinone-based human H1 and H3 single-ligand antagonists suitable for intranasal administration for the treatment of allergic rhinitis.
    Journal of medicinal chemistry, 2011, Apr-14, Volume: 54, Issue:7

    Topics: Administration, Intranasal; Administration, Oral; Drug Discovery; Histamine H1 Antagonists; Histamin

2011
Azelastine nasal spray inhibiting sympathetic function on human nasal mucosa in patients with allergy rhinitis.
    Rhinology, 2019, Aug-01, Volume: 57, Issue:4

    Topics: Administration, Intranasal; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Humans; Na

2019
Postnasal drip and chronic cough: An open interventional study.
    Respiratory medicine, 2009, Volume: 103, Issue:11

    Topics: Administration, Intranasal; Adolescent; Adult; Aged; Androstadienes; Anti-Inflammatory Agents, Non-S

2009
Alteration of brain activation patterns in nonallergic rhinitis patients using functional magnetic resonance imaging before and after treatment with intranasal azelastine.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2011, Volume: 106, Issue:6

    Topics: Administration, Intranasal; Adult; Brain; Female; Humans; Longitudinal Studies; Magnetic Resonance I

2011
Studies of nasal sprays for rhinitis.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2000, Volume: 85, Issue:5

    Topics: Administration, Intranasal; Bronchodilator Agents; Double-Blind Method; Humans; Phthalazines; Rhinit

2000