azelastine has been researched along with Muscle Contraction in 18 studies
azelastine: azeptin is azelastine hydrochloride; structure; eye drop formulation effective in relieving symptoms of allergic conjunctivitis; do not confuse with 5-loxin which is an extract of Boswellia
azelastine : A phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We examined the effectiveness of azelastine on isolated rat tracheal smooth muscle by testing: 1) the effect on tracheal smooth muscle resting tension; 2) the effect on contraction caused by 10(-6) M methacholine as a parasympathetic mimetic; and 3) the effect on electrically induced tracheal smooth muscle contractions." | 3.76 | Azelastine nasal spray inhibiting parasympathetic function of tracheal smooth muscle. ( Chou, YL; Chu, YH; Wang, HW, 2010) |
| "Azelastine is a newly developed antiallergic drug that is reported to antagonize histamine and leukotrienes in addition to its inhibitory action on release of chemical mediators." | 1.28 | Effects of azelastine on vagal neuroeffector transmission in canine and human airway smooth muscle. ( Aizawa, H; Ikeda, T; Inoue, H; Ito, Y; Miyazaki, N; Shigematsu, N, 1990) |
| "Azelastine is a phthalazinone derivative with a wide spectrum of pharmacological activities." | 1.27 | Inhibition of cysteinyl-leukotriene production by azelastine and its biological significance. ( Achterrath-Tuckermann, U; Luck, W; Peskar, BA; Simmet, T; Szelenyi, I, 1988) |
| " In the isolated guinea pig ileum, the dose-response curve for histamine was shifted to the right by 10(-8) mol/l of diphenhydramine, clemastine or azelastine to the same degree." | 1.26 | Effects of azelastine hydrochloride, a new antiallergic drug, on the gastrointestinal tract. ( Igarashi, T; Murakami, M; Shoji, T; Yamanaka, T, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (33.33) | 18.7374 |
| 1990's | 10 (55.56) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 1 (5.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, HW | 1 |
| Chou, YL | 1 |
| Chu, YH | 1 |
| Neves, JS | 1 |
| Coelho, LP | 1 |
| Cordeiro, RS | 1 |
| Veloso, MP | 1 |
| Rodrigues e Silva, PM | 1 |
| dos Santos, MH | 1 |
| Martins, MA | 1 |
| Yamanaka, T | 1 |
| Shoji, T | 1 |
| Murakami, M | 1 |
| Igarashi, T | 1 |
| Inoue, Y | 1 |
| Leitch, IM | 1 |
| Temple, DM | 1 |
| Wei, H | 1 |
| Boura, AL | 1 |
| Kamikawa, Y | 2 |
| Hazama, H | 1 |
| Nakajima, T | 1 |
| Hisada, T | 1 |
| Hamada, E | 1 |
| Omata, M | 1 |
| Kurachi, Y | 1 |
| Watanabe, K | 1 |
| Nagasawa, N | 1 |
| Wen, FQ | 1 |
| Inoue, K | 1 |
| Kuroda, K | 1 |
| Yoshida, M | 1 |
| Zhang, MQ | 1 |
| Timmerman, H | 1 |
| Sanagi, M | 1 |
| Ozaki, H | 1 |
| Mitsui, M | 1 |
| Karaki, H | 1 |
| Masuo, M | 1 |
| Shimada, T | 1 |
| Kitazawa, T | 1 |
| Aizawa, H | 1 |
| Inoue, H | 1 |
| Miyazaki, N | 1 |
| Ikeda, T | 1 |
| Shigematsu, N | 1 |
| Ito, Y | 1 |
| Richards, IS | 1 |
| Miller, L | 1 |
| Solomon, D | 1 |
| Kulkarni, A | 1 |
| Brooks, S | 1 |
| Sperelakis, N | 2 |
| Lee, HK | 1 |
| Ohya, Y | 1 |
| Doupnik, CA | 1 |
| Achterrath-Tuckermann, U | 2 |
| Simmet, T | 1 |
| Luck, W | 1 |
| Szelenyi, I | 2 |
| Peskar, BA | 1 |
| Chand, N | 1 |
| Diamantis, W | 1 |
| Sofia, RD | 1 |
18 other studies available for azelastine and Muscle Contraction
| Article | Year |
|---|---|
Azelastine nasal spray inhibiting parasympathetic function of tracheal smooth muscle.
Topics: Animals; Electric Stimulation; Histamine H1 Antagonists, Non-Sedating; Methacholine Chloride; Muscle | 2010 |
Antianaphylactic properties of 7-epiclusianone, a tetraprenylated benzophenone isolated from Garcinia brasiliensis.
Topics: Allergens; Animals; Anti-Allergic Agents; Benzophenones; Benzoquinones; Dose-Response Relationship, | 2007 |
Effects of azelastine hydrochloride, a new antiallergic drug, on the gastrointestinal tract.
Topics: Animals; Bile; Clemastine; Digestive System; Diphenhydramine; Gastrointestinal Motility; Histamine H | 1981 |
[Experimental study on an antihypersensitivity agent, 4-(p-chlorobenzyl)-2-[N-methyl-perhydroazepinyl-(4)]-1-(2H)-phthalazinone hydrochloride (azelastine)].
Topics: Animals; Female; Guinea Pigs; Histamine H1 Antagonists; Hypersensitivity, Immediate; In Vitro Techni | 1983 |
Some anti-allergic and anti-inflammatory actions of 2-N-carboxamidinonormianserin (FCC5).
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Drug | 1995 |
Influence of epithelial removal on the antihistaminic activity of azelastine in the guinea-pig airway smooth muscles.
Topics: Animals; Bronchi; Carbachol; Epithelium; Guinea Pigs; Histamine; Histamine H1 Antagonists; In Vitro | 1993 |
Effects of azelastine on membrane currents in tracheal smooth muscle cells isolated from the guinea-pig.
Topics: Animals; Calcium; Cell Membrane; Electrophysiology; Guinea Pigs; Histamine H1 Antagonists; In Vitro | 1994 |
Azelastine suppresses the release of arachidonic acid metabolites from cultured human umbilical vein endothelial cells.
Topics: Anti-Allergic Agents; Arachidonic Acid; Bronchoconstriction; Cells, Cultured; Chromatography, High P | 1997 |
Leukotriene cysLT1 (LTD4) receptor antagonism of H1-antihistamines: an in vitro study.
Topics: Animals; Butyrophenones; Cell Membrane; Chromones; Cyproheptadine; Guinea Pigs; Histamine H1 Antagon | 1997 |
Mechanism of relaxing action of the antiasthmatic drug, azelastine, in isolated porcine tracheal smooth muscle.
Topics: Animals; Bronchodilator Agents; Carbachol; Cyclic AMP; Cyclic GMP; Endothelins; Muscle Contraction; | 1992 |
Mechanism of inhibitory effects of azelastine on smooth muscle contraction.
Topics: Animals; Calcium; Calcium Channels; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guine | 1992 |
Effects of azelastine on vagal neuroeffector transmission in canine and human airway smooth muscle.
Topics: Acetylcholine; Animals; Bronchi; Dogs; Female; Histamine H1 Antagonists; Humans; In Vitro Techniques | 1990 |
Azelastine and desmethylazelastine suppress acetylcholine-induced contraction and depolarization in human airway smooth muscle.
Topics: Acetylcholine; Electrophysiology; Histamine H1 Antagonists; Humans; In Vitro Techniques; Isometric C | 1990 |
Effects of azelastine on contraction of guinea pig tracheal smooth muscle.
Topics: Action Potentials; Animals; Bronchodilator Agents; Dose-Response Relationship, Drug; Guinea Pigs; In | 1990 |
Inhibitory effect of anti-allergic drugs on cholinergic and non-cholinergic neurotransmissions of guinea pig bronchial muscle in vitro.
Topics: Acetylcholine; Animals; Bronchi; Cholinergic Fibers; Cromolyn Sodium; Electric Stimulation; Guinea P | 1989 |
Inhibition of cysteinyl-leukotriene production by azelastine and its biological significance.
Topics: Animals; Antigens; Arachidonic Acid; Arachidonic Acids; Bronchi; Guinea Pigs; Histamine H1 Antagonis | 1988 |
Azelastine inhibits bronchial hyperreactivity to acetylcholine in guinea pigs.
Topics: Acetylcholine; Animals; Antigens; Asthma; Bronchi; Guinea Pigs; Histamine; Histamine H1 Antagonists; | 1988 |
Modulation of in vitro anaphylaxis of guinea-pig isolated tracheal segments by azelastine, inhibitors of arachidonic acid metabolism and selected antiallergic drugs.
Topics: Airway Resistance; Anaphylaxis; Animals; Antigens; Arachidonic Acid; Arachidonic Acids; Guinea Pigs; | 1986 |