azelaic acid has been researched along with Malignant Melanoma in 29 studies
nonanedioic acid : An alpha,omega-dicarboxylic acid that is heptane substituted at positions 1 and 7 by carboxy groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Azelaic acid has been shown to have a dose- and time-dependent inhibitory effect on both proliferation and cell viability of murine and human melanoma cells at a concentration of 10(-3) M and higher." | 8.77 | Hyperpigmentary disorders--mechanisms of action. Effect of azelaic acid on melanoma and other tumoral cells in culture. ( Breathnach, AS; Nazzaro-Porro, M; Passi, S; Picardo, M; Robins, EJ, 1989) |
| " In this study, we investigated the antimelanogenic activity of combination of AZ and taurine (Tau) in B16F10 mouse melanoma cells." | 7.76 | Effect of combination of taurine and azelaic acid on antimelanogenesis in murine melanoma cells. ( Kim, AK; Yu, JS, 2010) |
| "Using a clonogenic assay in vitro, it has been shown that exposure to azelaic acid (1-100 mM) for 24 hours has a dose-dependent effect on the survival of the colony-forming ability of murine (B16) and human (HMB2, and SK23) melanoma cells as compared with a non-melanotic non-tumoral Chinese hamster cell line (CHO)." | 7.69 | Effect of azelaic acid on melanoma cells in culture. ( Breathnach, AS; Lemic-Stojcevic, L; Nias, AH, 1995) |
| "Azelaic acid has been shown to inhibit thioredoxin reductase (TR) at the surface of guinea pig and human skin, on cultures of human keratinocytes, melanocytes, melanoma cells, murine melanoma cells (Cloudman S91), and on purified enzymes from Escherichia coli, rat liver, and human melanoma." | 7.67 | Azelaic acid as a competitive inhibitor of thioredoxin reductase in human melanoma cells. ( Schallreuter, KU; Wood, JM, 1987) |
| "Azelaic acid, a linear C9 dicarbonic acid, can effect a reduction in the growth of melanoma cells." | 7.67 | [Effect of azelaic acid on the growth of melanoma cell cultures in comparison with fibroblast cultures]. ( Bauer, R; Geier, G; Hauschild, T; Kreysel, HW, 1986) |
| "The cytotoxic effect of azelaic acid on murine melanoma cells in culture is due, at least in part, to an antimitochondrial action." | 7.67 | Effect of L-carnitine on cultured murine melanoma cells exposed to azelaic acid. ( Bhasin, YP; Breathnach, AS; Ethridge, L; Nazzaro-Porro, M; Passi, S; Robins, EJ; Ward, BJ, 1986) |
| "Azelaic acid was successfully used in the clinical treatment of 7 cases of lentigo maligna in that remission of the lesions was observed in all our patients." | 7.67 | Inhibition of DNA synthesis of melanoma cells by azelaic acid. ( Konrad, K; Korschan, H; Leibl, H; Pehamberger, H; Stingl, G; Wolff, K, 1985) |
| "In 23 patients with malignant melanoma, including some with metastases and terminal patients, topical and oral (10--15 g daily) azelaic acid given for 1--12 weeks before surgical excision of the lesions was followed by arrest and subsequent regression of the advancing edge of lesions, reduction in size and flattening of nodular areas, and progressive lightening of pigmentation." | 7.66 | Effect of azelaic acid on human malignant melanoma. ( Bernengo, A; Breathnach, A; Gallagher, S; Morpurgo, G; Nazzaro-Porro, M; Passi, S; Zina, G, 1980) |
| "Azelaic acid (AzAc) is a C9 dicarboxylic acid which has recently been shown to have some therapeutic applications in skin diseases of different aetiologies." | 5.29 | Karyotype modifications in human malignant melanoma cell cultures after treatment with azelaic acid. ( Del Porto, G; Grammatico, P; Nazzaro-Porro, M; Picardo, M; Scarpa, S; Steindl, K, 1993) |
| "Melphalan was the most active drug followed by CCNU, fotemustine, and 4-HA." | 5.29 | Azelaic acid was sensitizing effect in the chemotherapeutic treatment of several melanoma cell lines. ( Rodriguez-Vicente, J; Vicente-Ortega, V, 1996) |
| "Azelaic acid has been shown clinically to have a cytotoxic effect on the abnormally active and malignant human melanocyte, but it has no apparent effect upon normal melanocytes." | 5.27 | Ultrastructural observations on the effect of azelaic acid on normal human melanocytes and a human melanoma cell line in tissue culture. ( Bennett, D; Bhasin, Y; Breathnach, AS; Ethridge, L; Nazzaro-Porro, M; Passi, S; Picardo, M; Robins, EJ; Ward, BJ, 1985) |
| "Azelaic acid has been shown to have a dose- and time-dependent inhibitory effect on both proliferation and cell viability of murine and human melanoma cells at a concentration of 10(-3) M and higher." | 4.77 | Hyperpigmentary disorders--mechanisms of action. Effect of azelaic acid on melanoma and other tumoral cells in culture. ( Breathnach, AS; Nazzaro-Porro, M; Passi, S; Picardo, M; Robins, EJ, 1989) |
| " In this study, we investigated the antimelanogenic activity of combination of AZ and taurine (Tau) in B16F10 mouse melanoma cells." | 3.76 | Effect of combination of taurine and azelaic acid on antimelanogenesis in murine melanoma cells. ( Kim, AK; Yu, JS, 2010) |
| "Using a clonogenic assay in vitro, it has been shown that exposure to azelaic acid (1-100 mM) for 24 hours has a dose-dependent effect on the survival of the colony-forming ability of murine (B16) and human (HMB2, and SK23) melanoma cells as compared with a non-melanotic non-tumoral Chinese hamster cell line (CHO)." | 3.69 | Effect of azelaic acid on melanoma cells in culture. ( Breathnach, AS; Lemic-Stojcevic, L; Nias, AH, 1995) |
| "A direct cytotoxic effect of azelaic acid on melanocytes of human melanoma has been demonstrated." | 3.67 | Distribution of radiolabelled azelaic cid in eye membranes and fluids of rabbits. ( Ciardiello, A; Greco, AV; Mingrone, G; Nazzro-Porro, M; Passo, S, 1984) |
| "Azelaic acid (AZA) has been reported to have an inhibitory effect on DNA synthesis of melanoma cell lines." | 3.67 | Azelaic acid: mode of action at cellular and subcellular levels. ( Galhaup, I, 1989) |
| "Cultures of human melanoma cell line B0008 were exposed to the disodium salts of azelaic acid (C9 2Na), adipic acid (C6 2Na) and dodecanediaic acid (C12 2Na) at 10(-2) M and 5 x 10(-2) M for 24 hrs." | 3.67 | Observations on cell kinetics and viability of a human melanoma cell line exposed to dicarboxylic acids in tissue culture. ( Bhasin, Y; Breathnach, AS; Ethridge, L; Nazzaro-Porro, M; Passi, S; Picardo, M; Robins, EJ, 1986) |
| "Azelaic acid has been shown to inhibit thioredoxin reductase (TR) at the surface of guinea pig and human skin, on cultures of human keratinocytes, melanocytes, melanoma cells, murine melanoma cells (Cloudman S91), and on purified enzymes from Escherichia coli, rat liver, and human melanoma." | 3.67 | Azelaic acid as a competitive inhibitor of thioredoxin reductase in human melanoma cells. ( Schallreuter, KU; Wood, JM, 1987) |
| "Azelaic acid, a linear C9 dicarbonic acid, can effect a reduction in the growth of melanoma cells." | 3.67 | [Effect of azelaic acid on the growth of melanoma cell cultures in comparison with fibroblast cultures]. ( Bauer, R; Geier, G; Hauschild, T; Kreysel, HW, 1986) |
| "The cytotoxic effect of azelaic acid on murine melanoma cells in culture is due, at least in part, to an antimitochondrial action." | 3.67 | Effect of L-carnitine on cultured murine melanoma cells exposed to azelaic acid. ( Bhasin, YP; Breathnach, AS; Ethridge, L; Nazzaro-Porro, M; Passi, S; Robins, EJ; Ward, BJ, 1986) |
| "In the past five years, it has been reported that certain dicarboxylic acids (C8-C13) and azelaic acid (C9) (AZA), in particular, have a remarkable effect in the management of lentigo maligna, human malignant melanoma, and certain disorders of hyperpigmentation." | 3.67 | An evaluation of the effectiveness of azelaic acid as a depigmenting and chemotherapeutic agent. ( Ciganek, ER; Farinelli, WA; Fitzpatrick, TB; Pathak, MA; Sober, AJ; Wick, M, 1985) |
| "Azelaic acid was successfully used in the clinical treatment of 7 cases of lentigo maligna in that remission of the lesions was observed in all our patients." | 3.67 | Inhibition of DNA synthesis of melanoma cells by azelaic acid. ( Konrad, K; Korschan, H; Leibl, H; Pehamberger, H; Stingl, G; Wolff, K, 1985) |
| "In 23 patients with malignant melanoma, including some with metastases and terminal patients, topical and oral (10--15 g daily) azelaic acid given for 1--12 weeks before surgical excision of the lesions was followed by arrest and subsequent regression of the advancing edge of lesions, reduction in size and flattening of nodular areas, and progressive lightening of pigmentation." | 3.66 | Effect of azelaic acid on human malignant melanoma. ( Bernengo, A; Breathnach, A; Gallagher, S; Morpurgo, G; Nazzaro-Porro, M; Passi, S; Zina, G, 1980) |
| "Azelaic acid is a naturally occurring straight-chained 9-carbon atom dicarboxylic acid which is non-toxic, non-teratogenic, and non-mutagenic." | 1.30 | Azelaic acid: potential as a general antitumoural agent. ( Breathnach, AS, 1999) |
| "Melphalan was the most active drug followed by CCNU, fotemustine, and 4-HA." | 1.29 | Azelaic acid was sensitizing effect in the chemotherapeutic treatment of several melanoma cell lines. ( Rodriguez-Vicente, J; Vicente-Ortega, V, 1996) |
| "Azelaic acid has been shown clinically to have a cytotoxic effect on the abnormally active and malignant human melanocyte, but it has no apparent effect upon normal melanocytes." | 1.27 | Ultrastructural observations on the effect of azelaic acid on normal human melanocytes and a human melanoma cell line in tissue culture. ( Bennett, D; Bhasin, Y; Breathnach, AS; Ethridge, L; Nazzaro-Porro, M; Passi, S; Picardo, M; Robins, EJ; Ward, BJ, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (68.97) | 18.7374 |
| 1990's | 7 (24.14) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (6.90) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Quigley, EA | 1 |
| Halpern, AC | 1 |
| Yu, JS | 1 |
| Kim, AK | 1 |
| Nazzaro-Porro, M | 12 |
| Passi, S | 10 |
| Zina, G | 2 |
| Bernengo, A | 1 |
| Breathnach, A | 1 |
| Gallagher, S | 1 |
| Morpurgo, G | 1 |
| Breathnach, AS | 12 |
| Mingrone, G | 1 |
| Greco, AV | 1 |
| Ciardiello, A | 1 |
| Passo, S | 1 |
| Nazzro-Porro, M | 1 |
| Willshaw, HE | 1 |
| Rubinstein, K | 1 |
| Lemic-Stojcevic, L | 1 |
| Nias, AH | 1 |
| Grammatico, P | 1 |
| Scarpa, S | 1 |
| Picardo, M | 7 |
| Steindl, K | 1 |
| Del Porto, G | 1 |
| Rodríguez Prieto, MA | 1 |
| Manchado Lopez, P | 1 |
| Ruiz Gonzalez, I | 1 |
| Suarez, D | 1 |
| Balus, L | 1 |
| Potenza, C | 1 |
| Rodriguez-Vicente, J | 1 |
| Vicente-Ortega, V | 1 |
| Galhaup, I | 1 |
| Robins, EJ | 7 |
| Pätzold, HC | 1 |
| Bhasin, YP | 3 |
| Ethridge, LB | 1 |
| Garner, A | 1 |
| Bhasin, Y | 2 |
| Ethridge, L | 5 |
| Sowden, J | 1 |
| Paramsothy, Y | 1 |
| Smith, AG | 1 |
| Schallreuter, KU | 1 |
| Wood, JM | 1 |
| Geier, G | 1 |
| Hauschild, T | 1 |
| Bauer, R | 1 |
| Kreysel, HW | 1 |
| McLean, DI | 1 |
| Peter, KK | 1 |
| Bashin, YP | 1 |
| Ward, BJ | 3 |
| Hu, F | 1 |
| Mah, K | 1 |
| Teramura, DJ | 1 |
| Pathak, MA | 1 |
| Ciganek, ER | 1 |
| Wick, M | 1 |
| Sober, AJ | 1 |
| Farinelli, WA | 1 |
| Fitzpatrick, TB | 1 |
| Leibl, H | 1 |
| Stingl, G | 1 |
| Pehamberger, H | 1 |
| Korschan, H | 1 |
| Konrad, K | 1 |
| Wolff, K | 1 |
| Bennett, D | 1 |
3 reviews available for azelaic acid and Malignant Melanoma
| Article | Year |
|---|---|
Microinvasive melanoma: cutaneous pharmacotherapeutic approaches.
Topics: Aged; Aged, 80 and over; Aminoquinolines; Antineoplastic Combined Chemotherapy Protocols; Biopsy, Ne | 2013 |
Azelaic acid.
Topics: Acne Vulgaris; Antineoplastic Agents; Dicarboxylic Acids; Humans; Melanoma; Nevus, Pigmented; Oxidat | 1984 |
Hyperpigmentary disorders--mechanisms of action. Effect of azelaic acid on melanoma and other tumoral cells in culture.
Topics: Animals; Antineoplastic Agents; Cell Division; Dicarboxylic Acids; DNA; Humans; Melanocytes; Melanom | 1989 |
26 other studies available for azelaic acid and Malignant Melanoma
| Article | Year |
|---|---|
Effect of combination of taurine and azelaic acid on antimelanogenesis in murine melanoma cells.
Topics: Animals; Cell Line, Tumor; Dicarboxylic Acids; Drug Combinations; Humans; Melanins; Melanocytes; Mel | 2010 |
Effect of azelaic acid on human malignant melanoma.
Topics: Administration, Oral; Administration, Topical; Dicarboxylic Acids; Follow-Up Studies; Humans; Melano | 1980 |
Distribution of radiolabelled azelaic cid in eye membranes and fluids of rabbits.
Topics: Animals; Antineoplastic Agents; Aqueous Humor; Dicarboxylic Acids; Eye; Eye Neoplasms; Male; Melanom | 1984 |
[Advances in pigment studies].
Topics: Dicarboxylic Acids; Humans; Lentigo; Melanins; Melanocytes; Melanoma; Pigmentation Disorders; Pituit | 1983 |
Azelaic acid in the treatment of ocular and adnexal malignant melanoma.
Topics: Aged; Antineoplastic Agents; Choroid Neoplasms; Conjunctival Neoplasms; Dicarboxylic Acids; Eye Neop | 1983 |
Effect of azelaic acid on melanoma cells in culture.
Topics: Animals; Antineoplastic Agents; Cell Division; CHO Cells; Cricetinae; Dicarboxylic Acids; Humans; Me | 1995 |
Karyotype modifications in human malignant melanoma cell cultures after treatment with azelaic acid.
Topics: Cell Division; Chromosomes; Dicarboxylic Acids; Genetic Markers; Humans; Karyotyping; Melanoma; Time | 1993 |
Treatment of lentigo maligna with azelaic acid.
Topics: Aged; Dermatologic Agents; Dicarboxylic Acids; Female; Humans; Lentigo; Male; Melanoma; Skin Neoplas | 1993 |
A case of recurrent (following surgery x2) invasive malignant melanoma with satellitosis (stage IIIA) successfully resolving after azelaic acid treatment administered by several routes.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Dicarboxylic Acids; Female; Humans; Melanoma; Neopla | 1996 |
Azelaic acid was sensitizing effect in the chemotherapeutic treatment of several melanoma cell lines.
Topics: Animals; Anisoles; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Cell Differentiation; C | 1996 |
Azelaic acid: potential as a general antitumoural agent.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Squamous Cell; Dicarboxylic Acids; Fema | 1999 |
The depigmenting effect of azelaic acid.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Dicarboxylic Acids; Guinea Pigs; Humans; Melanoma; | 1990 |
Azelaic acid: mode of action at cellular and subcellular levels.
Topics: Adipates; Animals; Cell Line; Cell Survival; Dicarboxylic Acids; DNA; Epidermal Cells; Epidermis; Hu | 1989 |
Effect of dicarboxylic acids (C6 and C9) on human choroidal melanoma in cell culture.
Topics: Adipates; Cell Count; Choroid Neoplasms; Dicarboxylic Acids; Humans; Melanocytes; Melanoma; Microsco | 1989 |
Observations on cell kinetics and viability of a human melanoma cell line exposed to dicarboxylic acids in tissue culture.
Topics: Adipates; Cell Count; Cell Death; Cell Division; Dicarboxylic Acids; Dose-Response Relationship, Dru | 1986 |
Malignant melanoma arising in the scar of lupus vulgaris and response to treatment with topical azelaic acid.
Topics: Administration, Topical; Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Cicatrix; Dicarboxyl | 1988 |
Azelaic acid as a competitive inhibitor of thioredoxin reductase in human melanoma cells.
Topics: Animals; Cells, Cultured; Dicarboxylic Acids; Electron Transport; Guinea Pigs; Humans; Melanocytes; | 1987 |
[Effect of azelaic acid on the growth of melanoma cell cultures in comparison with fibroblast cultures].
Topics: Antineoplastic Agents; Cell Division; Cell Line; Cell Survival; Dicarboxylic Acids; Dose-Response Re | 1986 |
Apparent progression of lentigo maligna to invasive melanoma during treatment with topical azelaic acid.
Topics: Aged; Dicarboxylic Acids; Female; Humans; Melanoma; Middle Aged; Neoplasm Invasiveness; Nevus, Pigme | 1986 |
Effectiveness of azelaic acid as a depigmenting and chemotherapeutic agent.
Topics: Animals; Dicarboxylic Acids; Guinea Pigs; Humans; Melanocytes; Melanoma; Mice; Skin Pigmentation | 1986 |
Effect of L-carnitine on cultured murine melanoma cells exposed to azelaic acid.
Topics: Animals; Antineoplastic Agents; Carnitine; Cell Line; Dicarboxylic Acids; Melanoma; Mice; Mitochondr | 1986 |
Effects of dicarboxylic acids on normal and malignant melanocytes in culture.
Topics: Animals; Cell Line; Dicarboxylic Acids; Macaca fascicularis; Macaca mulatta; Melanocytes; Melanoma; | 1986 |
Effect of dicarboxylic acids on Harding-Passey and Cloudman S91 melanoma cells in tissue culture.
Topics: Adipates; Animals; Cell Count; Cell Division; Cell Line; Cell Survival; Cells, Cultured; Dicarboxyli | 1985 |
An evaluation of the effectiveness of azelaic acid as a depigmenting and chemotherapeutic agent.
Topics: Animals; Dicarboxylic Acids; Drug Therapy; Guinea Pigs; Melanocytes; Melanoma; Pigmentation; Skin Pi | 1985 |
Inhibition of DNA synthesis of melanoma cells by azelaic acid.
Topics: Administration, Topical; Cells, Cultured; Depression, Chemical; Dicarboxylic Acids; DNA, Neoplasm; H | 1985 |
Ultrastructural observations on the effect of azelaic acid on normal human melanocytes and a human melanoma cell line in tissue culture.
Topics: Cell Line; Cells, Cultured; Dicarboxylic Acids; Epidermis; Humans; Infant, Newborn; Melanocytes; Mel | 1985 |