azelaic acid has been researched along with Chloasma in 24 studies
nonanedioic acid : An alpha,omega-dicarboxylic acid that is heptane substituted at positions 1 and 7 by carboxy groups.
Excerpt | Relevance | Reference |
---|---|---|
"Topical azelaic acid (AA) is indicated for acne and rosacea, but there is some evidence for its use for other dermatological conditions." | 9.41 | A systematic review to evaluate the efficacy of azelaic acid in the management of acne, rosacea, melasma and skin aging. ( Campbell, J; Daly, ML; King, S; Maybury, C; Moncrieff, G; Rowe, R, 2023) |
"Topical azelaic acid (AzA) is approved for the treatment of acne vulgaris and inflammatory (papulopustular) rosacea." | 8.83 | The use of topical azelaic acid for common skin disorders other than inflammatory rosacea. ( Del Rosso, JQ, 2006) |
"Patients treated with azelaic acid (15%) cream for chloasma reported simultaneous improvement of acne lesions within the treated areas." | 7.66 | Beneficial effect of 15% azelaic acid cream on acne vulgaris. ( Breathnach, A; Clayton, R; Nazzaro-Porro, M; Passi, S; Picardo, M; Zina, G, 1983) |
"Topical azelaic acid (AA) is indicated for acne and rosacea, but there is some evidence for its use for other dermatological conditions." | 5.41 | A systematic review to evaluate the efficacy of azelaic acid in the management of acne, rosacea, melasma and skin aging. ( Campbell, J; Daly, ML; King, S; Maybury, C; Moncrieff, G; Rowe, R, 2023) |
"Topical azelaic acid (AzA) is approved for the treatment of acne vulgaris and inflammatory (papulopustular) rosacea." | 4.83 | The use of topical azelaic acid for common skin disorders other than inflammatory rosacea. ( Del Rosso, JQ, 2006) |
"Patients treated with azelaic acid (15%) cream for chloasma reported simultaneous improvement of acne lesions within the treated areas." | 3.66 | Beneficial effect of 15% azelaic acid cream on acne vulgaris. ( Breathnach, A; Clayton, R; Nazzaro-Porro, M; Passi, S; Picardo, M; Zina, G, 1983) |
" Original studies that reported pre- and post-treatment Melasma Area Severity Index (MASI)/modified Melasma Area Severity Index (mMASI) scores and/or adverse effects (AEs) were eligible for inclusion." | 3.01 | Efficacy and safety of topical agents in the treatment of melasma: What's evidence? A systematic review and meta-analysis. ( Aljabban, A; Bain, PA; Bay, CP; Chang, YF; Chung, HJ; Desai, SR; Lee, TL; Oyerinde, O, 2023) |
" Melasma is an irregular brown or grayish-brown symmetric facial hypermelanosis, often affecting women, especially those living in areas with intense ultraviolet radiation." | 2.76 | Comparative study of therapeutic effects of 20% azelaic acid and hydroquinone 4% cream in the treatment of melasma. ( Farshi, S, 2011) |
" Therefore, the present study suggests that combined treatment with serial glycolic acid peels, azelaic acid cream and adapalene gel should be considered as an effective and safe therapy in recalcitrant melasma." | 2.73 | Efficacy and safety of serial glycolic acid peels and a topical regimen in the treatment of recalcitrant melasma. ( Arca, E; Erbil, H; Kurumlu, Z; Sezer, E; Taştan, B, 2007) |
"Melasma is a commonly found hyperpigmentary disorder in dark-complexioned persons, which is rather difficult to treat." | 2.70 | A comparative study of 20% azelaic acid cream monotherapy versus a sequential therapy in the treatment of melasma in dark-skinned patients. ( Bhalla, M; Kanwar, AJ; Sarkar, R, 2002) |
"Melasma is a macular hypermelanosis of the sun-exposed areas of the face and neck." | 2.66 | Double-blind comparison of azelaic acid and hydroquinone in the treatment of melasma. ( Garcia-Lopez, M; Graupe, K; Lopez-Villafuerte, L; Verallo, V; Verallo-Rowell, VM, 1989) |
"Azelaic acid is a complex molecule with many diverse activities." | 2.52 | Azelaic Acid: Evidence-based Update on Mechanism of Action and Clinical Application. ( Rosen, T; Schulte, BC; Wu, W, 2015) |
"Melasma is an irregular brown or grayish-brown facial hypermelanosis, often affecting women, especially those living in areas of intense UV radiation." | 2.43 | The treatment of melasma: a review of clinical trials. ( Gover, MD; Gupta, AK; Nouri, K; Taylor, S, 2006) |
"Melasma is a common acquired symmetric hypermelanosis characterized by irregular light- to gray-brown macules and patches involving sun-exposed areas of skin." | 2.39 | Melasma. Etiologic and therapeutic considerations. ( Grimes, PE, 1995) |
"Tretinoin appears to enhance this effect of azelaic acid." | 2.39 | Melanin hyperpigmentation of skin: melasma, topical treatment with azelaic acid, and other therapies. ( Breathnach, AS, 1996) |
"Oral tranexamic acid 250 mg was taken by both groups as a single oral daily dose." | 1.72 | Liposomal azelaic acid 20% cream vs hydroquinone 4% cream as adjuvant to oral tranexamic acid in melasma: a comparative study. ( Akl, EM, 2022) |
"Dermic melasma is a recalcitrant disease." | 1.51 | Azelaic acid-loaded nanoemulsion with hyaluronic acid - a new strategy to treat hyperpigmentary skin disorders. ( Davies, S; De Villa, D; Guterres, SS; Jacobus Berlitz, S; Külkamp-Guerreiro, IC; Maschmann Inácio, LA; Zatta, KC, 2019) |
"Melasma is one of the most frequently diagnosed hyperpigmentation changes on the skin of women's faces." | 1.43 | Comparison of efficacy of products containing azelaic acid in melasma treatment. ( Mazurek, K; Pierzchała, E, 2016) |
"A classification of melasma is based on Wood's light examination, classifying it in four major clinical types and patterns: epidermal, dermal, mixed, and indeterminate." | 1.34 | Therapeutical approaches in melasma. ( Buggiani, G; Lotti, T; Ortonne, JP; Prignano, F, 2007) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 4 (16.67) | 18.7374 |
1990's | 3 (12.50) | 18.2507 |
2000's | 6 (25.00) | 29.6817 |
2010's | 8 (33.33) | 24.3611 |
2020's | 3 (12.50) | 2.80 |
Authors | Studies |
---|---|
Chang, YF | 1 |
Lee, TL | 1 |
Oyerinde, O | 1 |
Desai, SR | 1 |
Aljabban, A | 1 |
Bay, CP | 1 |
Bain, PA | 1 |
Chung, HJ | 1 |
King, S | 1 |
Campbell, J | 1 |
Rowe, R | 1 |
Daly, ML | 1 |
Moncrieff, G | 1 |
Maybury, C | 1 |
Akl, EM | 1 |
Jacobus Berlitz, S | 1 |
De Villa, D | 1 |
Maschmann Inácio, LA | 1 |
Davies, S | 1 |
Zatta, KC | 1 |
Guterres, SS | 1 |
Külkamp-Guerreiro, IC | 1 |
Pekmezci, E | 1 |
Malik, F | 1 |
Hanif, MM | 1 |
Mustafa, G | 1 |
Schulte, BC | 1 |
Wu, W | 1 |
Rosen, T | 1 |
Mazurek, K | 1 |
Pierzchała, E | 1 |
Dayal, S | 1 |
Sahu, P | 1 |
Dua, R | 1 |
Sheth, VM | 1 |
Pandya, AG | 1 |
Farshi, S | 1 |
Sarkar, R | 1 |
Bhalla, M | 1 |
Kanwar, AJ | 1 |
Cayce, KA | 1 |
McMichael, AJ | 1 |
Feldman, SR | 1 |
Del Rosso, JQ | 1 |
Gupta, AK | 1 |
Gover, MD | 1 |
Nouri, K | 1 |
Taylor, S | 1 |
Erbil, H | 1 |
Sezer, E | 1 |
Taştan, B | 1 |
Arca, E | 1 |
Kurumlu, Z | 1 |
Prignano, F | 1 |
Ortonne, JP | 2 |
Buggiani, G | 1 |
Lotti, T | 1 |
Nazzaro-Porro, M | 1 |
Passi, S | 1 |
Picardo, M | 1 |
Breathnach, A | 1 |
Clayton, R | 1 |
Zina, G | 1 |
Grimes, PE | 1 |
Breathnach, AS | 1 |
Baliña, LM | 1 |
Graupe, K | 2 |
Verallo-Rowell, VM | 1 |
Verallo, V | 1 |
Lopez-Villafuerte, L | 1 |
Garcia-Lopez, M | 1 |
Piquero Martín, J | 1 |
Rothe de Arocha, J | 1 |
Beniamini Loker, D | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Combined Trichlotoaceticacid and Microneedle Versus Trichlroacetic Acid Alone in the Treatment of Melasma[NCT03472235] | 40 participants (Anticipated) | Interventional | 2018-04-05 | Not yet recruiting | |||
Different Dermatological Approaches in Treatment of Melasma: A Split Face Randomized Clinical Trial[NCT03923062] | Phase 4 | 40 participants (Anticipated) | Interventional | 2020-02-01 | Not yet recruiting | ||
THE METFORMIN AND TRICHLOROACETIC ACID IN TREATMENT OF MELASMA[NCT03475524] | Phase 4 | 60 participants (Anticipated) | Interventional | 2019-04-01 | Recruiting | ||
Solar Lentigines Treatment With the Triple Combination Cream (Hydroquinone 4%, Tretinoin 0.05%, and Fluocinolone Acetonide 0.01%). Randomized, Double Blind, Controlled Trial.[NCT00975312] | Phase 2 | 22 participants (Actual) | Interventional | 2008-08-31 | Completed | ||
The Efficacy of Combined Peels in Treatment of Melasma Using Modified Jessner's Solution With 20%Trichloroacetic Acid Versus 70%Glycolic Acid With 20% Trichloroacetic Acid : A Split-face Study[NCT03153852] | Phase 4 | 30 participants (Anticipated) | Interventional | 2018-03-15 | Not yet recruiting | ||
Evaluation of the Therapeutic Effect of Platelet Rich Plasma in Melasma[NCT03308370] | Phase 3 | 26 participants (Anticipated) | Interventional | 2017-11-01 | Recruiting | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
9 reviews available for azelaic acid and Chloasma
Article | Year |
---|---|
Efficacy and safety of topical agents in the treatment of melasma: What's evidence? A systematic review and meta-analysis.
Topics: Cysteamine; Humans; Melanosis; Tranexamic Acid; Treatment Outcome; Zinc Sulfate | 2023 |
A systematic review to evaluate the efficacy of azelaic acid in the management of acne, rosacea, melasma and skin aging.
Topics: Acne Vulgaris; Dermatologic Agents; Erythema; Humans; Melanosis; Rosacea; Skin Aging; Treatment Outc | 2023 |
Azelaic Acid: Evidence-based Update on Mechanism of Action and Clinical Application.
Topics: Acne Vulgaris; Alopecia Areata; Dermatitis, Perioral; Dermatologic Agents; Dicarboxylic Acids; Facia | 2015 |
Melasma: a comprehensive update: part II.
Topics: Administration, Topical; Asian People; Chemexfoliation; Dicarboxylic Acids; Drug Therapy, Combinatio | 2011 |
Melasma: a comprehensive update: part II.
Topics: Administration, Topical; Asian People; Chemexfoliation; Dicarboxylic Acids; Drug Therapy, Combinatio | 2011 |
Melasma: a comprehensive update: part II.
Topics: Administration, Topical; Asian People; Chemexfoliation; Dicarboxylic Acids; Drug Therapy, Combinatio | 2011 |
Melasma: a comprehensive update: part II.
Topics: Administration, Topical; Asian People; Chemexfoliation; Dicarboxylic Acids; Drug Therapy, Combinatio | 2011 |
Melasma: a comprehensive update: part II.
Topics: Administration, Topical; Asian People; Chemexfoliation; Dicarboxylic Acids; Drug Therapy, Combinatio | 2011 |
Melasma: a comprehensive update: part II.
Topics: Administration, Topical; Asian People; Chemexfoliation; Dicarboxylic Acids; Drug Therapy, Combinatio | 2011 |
Melasma: a comprehensive update: part II.
Topics: Administration, Topical; Asian People; Chemexfoliation; Dicarboxylic Acids; Drug Therapy, Combinatio | 2011 |
Melasma: a comprehensive update: part II.
Topics: Administration, Topical; Asian People; Chemexfoliation; Dicarboxylic Acids; Drug Therapy, Combinatio | 2011 |
Melasma: a comprehensive update: part II.
Topics: Administration, Topical; Asian People; Chemexfoliation; Dicarboxylic Acids; Drug Therapy, Combinatio | 2011 |
Hyperpigmentation: an overview of the common afflictions.
Topics: Chemexfoliation; Cryotherapy; Dermatologic Agents; Dicarboxylic Acids; Humans; Hydroquinones; Hyperp | 2004 |
The use of topical azelaic acid for common skin disorders other than inflammatory rosacea.
Topics: Administration, Cutaneous; Dermatitis, Perioral; Dermatologic Agents; Dicarboxylic Acids; Humans; Me | 2006 |
The treatment of melasma: a review of clinical trials.
Topics: Adrenal Cortex Hormones; Adult; Chemexfoliation; Clinical Trials as Topic; Combined Modality Therapy | 2006 |
The treatment of melasma: a review of clinical trials.
Topics: Adrenal Cortex Hormones; Adult; Chemexfoliation; Clinical Trials as Topic; Combined Modality Therapy | 2006 |
The treatment of melasma: a review of clinical trials.
Topics: Adrenal Cortex Hormones; Adult; Chemexfoliation; Clinical Trials as Topic; Combined Modality Therapy | 2006 |
The treatment of melasma: a review of clinical trials.
Topics: Adrenal Cortex Hormones; Adult; Chemexfoliation; Clinical Trials as Topic; Combined Modality Therapy | 2006 |
Melasma. Etiologic and therapeutic considerations.
Topics: Administration, Cutaneous; Chemexfoliation; Dermatologic Agents; Dicarboxylic Acids; Female; Humans; | 1995 |
Melasma. Etiologic and therapeutic considerations.
Topics: Administration, Cutaneous; Chemexfoliation; Dermatologic Agents; Dicarboxylic Acids; Female; Humans; | 1995 |
Melasma. Etiologic and therapeutic considerations.
Topics: Administration, Cutaneous; Chemexfoliation; Dermatologic Agents; Dicarboxylic Acids; Female; Humans; | 1995 |
Melasma. Etiologic and therapeutic considerations.
Topics: Administration, Cutaneous; Chemexfoliation; Dermatologic Agents; Dicarboxylic Acids; Female; Humans; | 1995 |
Melanin hyperpigmentation of skin: melasma, topical treatment with azelaic acid, and other therapies.
Topics: Administration, Topical; Dermatologic Agents; Dicarboxylic Acids; Drug Therapy, Combination; Humans; | 1996 |
7 trials available for azelaic acid and Chloasma
Article | Year |
---|---|
Combination of glycolic acid peel and topical 20% azelaic acid cream in melasma patients: efficacy and improvement in quality of life.
Topics: Administration, Cutaneous; Adult; Chemexfoliation; Combined Modality Therapy; Dermatologic Agents; D | 2017 |
Comparative study of therapeutic effects of 20% azelaic acid and hydroquinone 4% cream in the treatment of melasma.
Topics: Adult; Antioxidants; Dermatologic Agents; Dicarboxylic Acids; Emollients; Female; Humans; Hydroquino | 2011 |
A comparative study of 20% azelaic acid cream monotherapy versus a sequential therapy in the treatment of melasma in dark-skinned patients.
Topics: Administration, Topical; Adult; Anti-Inflammatory Agents; Clobetasol; Dermatologic Agents; Dicarboxy | 2002 |
Efficacy and safety of serial glycolic acid peels and a topical regimen in the treatment of recalcitrant melasma.
Topics: Adapalene; Administration, Topical; Adult; Chemexfoliation; Dermatologic Agents; Dicarboxylic Acids; | 2007 |
The treatment of melasma. 20% azelaic acid versus 4% hydroquinone cream.
Topics: Administration, Cutaneous; Adolescent; Adult; Dermatologic Agents; Dicarboxylic Acids; Double-Blind | 1991 |
Double-blind comparison of azelaic acid and hydroquinone in the treatment of melasma.
Topics: Administration, Topical; Dicarboxylic Acids; Double-Blind Method; Drug Eruptions; Female; Humans; Hy | 1989 |
[Double-blind clinical study of the treatment of melasma with azelaic acid versus hydroquinone].
Topics: Administration, Topical; Adolescent; Adult; Antineoplastic Agents; Clinical Trials as Topic; Dicarbo | 1988 |
8 other studies available for azelaic acid and Chloasma
Article | Year |
---|---|
Liposomal azelaic acid 20% cream vs hydroquinone 4% cream as adjuvant to oral tranexamic acid in melasma: a comparative study.
Topics: Adjuvants, Immunologic; Dermatologic Agents; Dicarboxylic Acids; Emollients; Female; Humans; Hydroqu | 2022 |
Azelaic acid-loaded nanoemulsion with hyaluronic acid - a new strategy to treat hyperpigmentary skin disorders.
Topics: Administration, Cutaneous; Animals; Cell Survival; Dermatologic Agents; Dicarboxylic Acids; Drug Del | 2019 |
A novel triple combination in treatment of melasma: Significant outcome with far less actives.
Topics: Administration, Cutaneous; Adult; Dermatologic Agents; Diagnostic Self Evaluation; Dicarboxylic Acid | 2019 |
Combination of Oral Tranexamic Acid with Topical 3% Tranexamic Acid versus Oral Tranexamic Acid with Topical 20% Azelaic Acid in the Treatment of Melasma.
Topics: Administration, Cutaneous; Administration, Oral; Adult; Antifibrinolytic Agents; Combined Modality T | 2019 |
Comparison of efficacy of products containing azelaic acid in melasma treatment.
Topics: Adult; Cosmeceuticals; Dermatologic Agents; Dicarboxylic Acids; Drug Combinations; Female; Humans; M | 2016 |
Therapeutical approaches in melasma.
Topics: Chemexfoliation; Cosmetics; Dermatologic Agents; Dicarboxylic Acids; Drug Combinations; Humans; Hydr | 2007 |
Beneficial effect of 15% azelaic acid cream on acne vulgaris.
Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Dicarboxylic Acids; Female; Humans; Male; | 1983 |
[Depigmenting chemical agents].
Topics: Dicarboxylic Acids; Humans; Hydroquinones; Melanosis; Skin Pigmentation | 1986 |