azelaic acid and Chloasma studies

nonanedioic acid : An alpha,omega-dicarboxylic acid that is heptane substituted at positions 1 and 7 by carboxy groups.

Research Excerpts

Excerpt	Relevance	Reference
"Topical azelaic acid (AA) is indicated for acne and rosacea, but there is some evidence for its use for other dermatological conditions."	9.41	A systematic review to evaluate the efficacy of azelaic acid in the management of acne, rosacea, melasma and skin aging. ( Campbell, J; Daly, ML; King, S; Maybury, C; Moncrieff, G; Rowe, R, 2023)
"Topical azelaic acid (AzA) is approved for the treatment of acne vulgaris and inflammatory (papulopustular) rosacea."	8.83	The use of topical azelaic acid for common skin disorders other than inflammatory rosacea. ( Del Rosso, JQ, 2006)
"Patients treated with azelaic acid (15%) cream for chloasma reported simultaneous improvement of acne lesions within the treated areas."	7.66	Beneficial effect of 15% azelaic acid cream on acne vulgaris. ( Breathnach, A; Clayton, R; Nazzaro-Porro, M; Passi, S; Picardo, M; Zina, G, 1983)
"Topical azelaic acid (AA) is indicated for acne and rosacea, but there is some evidence for its use for other dermatological conditions."	5.41	A systematic review to evaluate the efficacy of azelaic acid in the management of acne, rosacea, melasma and skin aging. ( Campbell, J; Daly, ML; King, S; Maybury, C; Moncrieff, G; Rowe, R, 2023)
"Topical azelaic acid (AzA) is approved for the treatment of acne vulgaris and inflammatory (papulopustular) rosacea."	4.83	The use of topical azelaic acid for common skin disorders other than inflammatory rosacea. ( Del Rosso, JQ, 2006)
"Patients treated with azelaic acid (15%) cream for chloasma reported simultaneous improvement of acne lesions within the treated areas."	3.66	Beneficial effect of 15% azelaic acid cream on acne vulgaris. ( Breathnach, A; Clayton, R; Nazzaro-Porro, M; Passi, S; Picardo, M; Zina, G, 1983)
" Original studies that reported pre- and post-treatment Melasma Area Severity Index (MASI)/modified Melasma Area Severity Index (mMASI) scores and/or adverse effects (AEs) were eligible for inclusion."	3.01	Efficacy and safety of topical agents in the treatment of melasma: What's evidence? A systematic review and meta-analysis. ( Aljabban, A; Bain, PA; Bay, CP; Chang, YF; Chung, HJ; Desai, SR; Lee, TL; Oyerinde, O, 2023)
" Melasma is an irregular brown or grayish-brown symmetric facial hypermelanosis, often affecting women, especially those living in areas with intense ultraviolet radiation."	2.76	Comparative study of therapeutic effects of 20% azelaic acid and hydroquinone 4% cream in the treatment of melasma. ( Farshi, S, 2011)
" Therefore, the present study suggests that combined treatment with serial glycolic acid peels, azelaic acid cream and adapalene gel should be considered as an effective and safe therapy in recalcitrant melasma."	2.73	Efficacy and safety of serial glycolic acid peels and a topical regimen in the treatment of recalcitrant melasma. ( Arca, E; Erbil, H; Kurumlu, Z; Sezer, E; Taştan, B, 2007)
"Melasma is a commonly found hyperpigmentary disorder in dark-complexioned persons, which is rather difficult to treat."	2.70	A comparative study of 20% azelaic acid cream monotherapy versus a sequential therapy in the treatment of melasma in dark-skinned patients. ( Bhalla, M; Kanwar, AJ; Sarkar, R, 2002)
"Melasma is a macular hypermelanosis of the sun-exposed areas of the face and neck."	2.66	Double-blind comparison of azelaic acid and hydroquinone in the treatment of melasma. ( Garcia-Lopez, M; Graupe, K; Lopez-Villafuerte, L; Verallo, V; Verallo-Rowell, VM, 1989)
"Azelaic acid is a complex molecule with many diverse activities."	2.52	Azelaic Acid: Evidence-based Update on Mechanism of Action and Clinical Application. ( Rosen, T; Schulte, BC; Wu, W, 2015)
"Melasma is an irregular brown or grayish-brown facial hypermelanosis, often affecting women, especially those living in areas of intense UV radiation."	2.43	The treatment of melasma: a review of clinical trials. ( Gover, MD; Gupta, AK; Nouri, K; Taylor, S, 2006)
"Melasma is a common acquired symmetric hypermelanosis characterized by irregular light- to gray-brown macules and patches involving sun-exposed areas of skin."	2.39	Melasma. Etiologic and therapeutic considerations. ( Grimes, PE, 1995)
"Tretinoin appears to enhance this effect of azelaic acid."	2.39	Melanin hyperpigmentation of skin: melasma, topical treatment with azelaic acid, and other therapies. ( Breathnach, AS, 1996)
"Oral tranexamic acid 250 mg was taken by both groups as a single oral daily dose."	1.72	Liposomal azelaic acid 20% cream vs hydroquinone 4% cream as adjuvant to oral tranexamic acid in melasma: a comparative study. ( Akl, EM, 2022)
"Dermic melasma is a recalcitrant disease."	1.51	Azelaic acid-loaded nanoemulsion with hyaluronic acid - a new strategy to treat hyperpigmentary skin disorders. ( Davies, S; De Villa, D; Guterres, SS; Jacobus Berlitz, S; Külkamp-Guerreiro, IC; Maschmann Inácio, LA; Zatta, KC, 2019)
"Melasma is one of the most frequently diagnosed hyperpigmentation changes on the skin of women's faces."	1.43	Comparison of efficacy of products containing azelaic acid in melasma treatment. ( Mazurek, K; Pierzchała, E, 2016)
"A classification of melasma is based on Wood's light examination, classifying it in four major clinical types and patterns: epidermal, dermal, mixed, and indeterminate."	1.34	Therapeutical approaches in melasma. ( Buggiani, G; Lotti, T; Ortonne, JP; Prignano, F, 2007)

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (16.67)	18.7374
1990's	3 (12.50)	18.2507
2000's	6 (25.00)	29.6817
2010's	8 (33.33)	24.3611
2020's	3 (12.50)	2.80

Trial	Phase	Enrollment	Study Type	Start Date	Status
Combined Trichlotoaceticacid and Microneedle Versus Trichlroacetic Acid Alone in the Treatment of Melasma[NCT03472235]		40 participants (Anticipated)	Interventional	2018-04-05	Not yet recruiting
Different Dermatological Approaches in Treatment of Melasma: A Split Face Randomized Clinical Trial[NCT03923062]	Phase 4	40 participants (Anticipated)	Interventional	2020-02-01	Not yet recruiting
THE METFORMIN AND TRICHLOROACETIC ACID IN TREATMENT OF MELASMA[NCT03475524]	Phase 4	60 participants (Anticipated)	Interventional	2019-04-01	Recruiting
Solar Lentigines Treatment With the Triple Combination Cream (Hydroquinone 4%, Tretinoin 0.05%, and Fluocinolone Acetonide 0.01%). Randomized, Double Blind, Controlled Trial.[NCT00975312]	Phase 2	22 participants (Actual)	Interventional	2008-08-31	Completed
The Efficacy of Combined Peels in Treatment of Melasma Using Modified Jessner's Solution With 20%Trichloroacetic Acid Versus 70%Glycolic Acid With 20% Trichloroacetic Acid : A Split-face Study[NCT03153852]	Phase 4	30 participants (Anticipated)	Interventional	2018-03-15	Not yet recruiting
Evaluation of the Therapeutic Effect of Platelet Rich Plasma in Melasma[NCT03308370]	Phase 3	26 participants (Anticipated)	Interventional	2017-11-01	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Efficacy and safety of topical agents in the treatment of melasma: What's evidence? A systematic review and meta-analysis. Journal of cosmetic dermatology, 2023, Volume: 22, Issue:4 Topics: Cysteamine; Humans; Melanosis; Tranexamic Acid; Treatment Outcome; Zinc Sulfate	2023
A systematic review to evaluate the efficacy of azelaic acid in the management of acne, rosacea, melasma and skin aging. Journal of cosmetic dermatology, 2023, Volume: 22, Issue:10 Topics: Acne Vulgaris; Dermatologic Agents; Erythema; Humans; Melanosis; Rosacea; Skin Aging; Treatment Outc	2023
Azelaic Acid: Evidence-based Update on Mechanism of Action and Clinical Application. Journal of drugs in dermatology : JDD, 2015, Volume: 14, Issue:9 Topics: Acne Vulgaris; Alopecia Areata; Dermatitis, Perioral; Dermatologic Agents; Dicarboxylic Acids; Facia	2015
Melasma: a comprehensive update: part II. Journal of the American Academy of Dermatology, 2011, Volume: 65, Issue:4 Topics: Administration, Topical; Asian People; Chemexfoliation; Dicarboxylic Acids; Drug Therapy, Combinatio	2011
Melasma: a comprehensive update: part II. Journal of the American Academy of Dermatology, 2011, Volume: 65, Issue:4 Topics: Administration, Topical; Asian People; Chemexfoliation; Dicarboxylic Acids; Drug Therapy, Combinatio	2011
Melasma: a comprehensive update: part II. Journal of the American Academy of Dermatology, 2011, Volume: 65, Issue:4 Topics: Administration, Topical; Asian People; Chemexfoliation; Dicarboxylic Acids; Drug Therapy, Combinatio	2011
Melasma: a comprehensive update: part II. Journal of the American Academy of Dermatology, 2011, Volume: 65, Issue:4 Topics: Administration, Topical; Asian People; Chemexfoliation; Dicarboxylic Acids; Drug Therapy, Combinatio	2011
Melasma: a comprehensive update: part II. Journal of the American Academy of Dermatology, 2011, Volume: 65, Issue:4 Topics: Administration, Topical; Asian People; Chemexfoliation; Dicarboxylic Acids; Drug Therapy, Combinatio	2011
Melasma: a comprehensive update: part II. Journal of the American Academy of Dermatology, 2011, Volume: 65, Issue:4 Topics: Administration, Topical; Asian People; Chemexfoliation; Dicarboxylic Acids; Drug Therapy, Combinatio	2011
Melasma: a comprehensive update: part II. Journal of the American Academy of Dermatology, 2011, Volume: 65, Issue:4 Topics: Administration, Topical; Asian People; Chemexfoliation; Dicarboxylic Acids; Drug Therapy, Combinatio	2011
Melasma: a comprehensive update: part II. Journal of the American Academy of Dermatology, 2011, Volume: 65, Issue:4 Topics: Administration, Topical; Asian People; Chemexfoliation; Dicarboxylic Acids; Drug Therapy, Combinatio	2011
Melasma: a comprehensive update: part II. Journal of the American Academy of Dermatology, 2011, Volume: 65, Issue:4 Topics: Administration, Topical; Asian People; Chemexfoliation; Dicarboxylic Acids; Drug Therapy, Combinatio	2011
Hyperpigmentation: an overview of the common afflictions. Dermatology nursing, 2004, Volume: 16, Issue:5 Topics: Chemexfoliation; Cryotherapy; Dermatologic Agents; Dicarboxylic Acids; Humans; Hydroquinones; Hyperp	2004
The use of topical azelaic acid for common skin disorders other than inflammatory rosacea. Cutis, 2006, Volume: 77, Issue:2 Suppl Topics: Administration, Cutaneous; Dermatitis, Perioral; Dermatologic Agents; Dicarboxylic Acids; Humans; Me	2006
The treatment of melasma: a review of clinical trials. Journal of the American Academy of Dermatology, 2006, Volume: 55, Issue:6 Topics: Adrenal Cortex Hormones; Adult; Chemexfoliation; Clinical Trials as Topic; Combined Modality Therapy	2006
The treatment of melasma: a review of clinical trials. Journal of the American Academy of Dermatology, 2006, Volume: 55, Issue:6 Topics: Adrenal Cortex Hormones; Adult; Chemexfoliation; Clinical Trials as Topic; Combined Modality Therapy	2006
The treatment of melasma: a review of clinical trials. Journal of the American Academy of Dermatology, 2006, Volume: 55, Issue:6 Topics: Adrenal Cortex Hormones; Adult; Chemexfoliation; Clinical Trials as Topic; Combined Modality Therapy	2006
The treatment of melasma: a review of clinical trials. Journal of the American Academy of Dermatology, 2006, Volume: 55, Issue:6 Topics: Adrenal Cortex Hormones; Adult; Chemexfoliation; Clinical Trials as Topic; Combined Modality Therapy	2006
Melasma. Etiologic and therapeutic considerations. Archives of dermatology, 1995, Volume: 131, Issue:12 Topics: Administration, Cutaneous; Chemexfoliation; Dermatologic Agents; Dicarboxylic Acids; Female; Humans;	1995
Melasma. Etiologic and therapeutic considerations. Archives of dermatology, 1995, Volume: 131, Issue:12 Topics: Administration, Cutaneous; Chemexfoliation; Dermatologic Agents; Dicarboxylic Acids; Female; Humans;	1995
Melasma. Etiologic and therapeutic considerations. Archives of dermatology, 1995, Volume: 131, Issue:12 Topics: Administration, Cutaneous; Chemexfoliation; Dermatologic Agents; Dicarboxylic Acids; Female; Humans;	1995
Melasma. Etiologic and therapeutic considerations. Archives of dermatology, 1995, Volume: 131, Issue:12 Topics: Administration, Cutaneous; Chemexfoliation; Dermatologic Agents; Dicarboxylic Acids; Female; Humans;	1995
Melanin hyperpigmentation of skin: melasma, topical treatment with azelaic acid, and other therapies. Cutis, 1996, Volume: 57, Issue:1 Suppl Topics: Administration, Topical; Dermatologic Agents; Dicarboxylic Acids; Drug Therapy, Combination; Humans;	1996

Article	Year
Combination of glycolic acid peel and topical 20% azelaic acid cream in melasma patients: efficacy and improvement in quality of life. Journal of cosmetic dermatology, 2017, Volume: 16, Issue:1 Topics: Administration, Cutaneous; Adult; Chemexfoliation; Combined Modality Therapy; Dermatologic Agents; D	2017
Comparative study of therapeutic effects of 20% azelaic acid and hydroquinone 4% cream in the treatment of melasma. Journal of cosmetic dermatology, 2011, Volume: 10, Issue:4 Topics: Adult; Antioxidants; Dermatologic Agents; Dicarboxylic Acids; Emollients; Female; Humans; Hydroquino	2011
A comparative study of 20% azelaic acid cream monotherapy versus a sequential therapy in the treatment of melasma in dark-skinned patients. Dermatology (Basel, Switzerland), 2002, Volume: 205, Issue:3 Topics: Administration, Topical; Adult; Anti-Inflammatory Agents; Clobetasol; Dermatologic Agents; Dicarboxy	2002
Efficacy and safety of serial glycolic acid peels and a topical regimen in the treatment of recalcitrant melasma. The Journal of dermatology, 2007, Volume: 34, Issue:1 Topics: Adapalene; Administration, Topical; Adult; Chemexfoliation; Dermatologic Agents; Dicarboxylic Acids;	2007
The treatment of melasma. 20% azelaic acid versus 4% hydroquinone cream. International journal of dermatology, 1991, Volume: 30, Issue:12 Topics: Administration, Cutaneous; Adolescent; Adult; Dermatologic Agents; Dicarboxylic Acids; Double-Blind	1991
Double-blind comparison of azelaic acid and hydroquinone in the treatment of melasma. Acta dermato-venereologica. Supplementum, 1989, Volume: 143 Topics: Administration, Topical; Dicarboxylic Acids; Double-Blind Method; Drug Eruptions; Female; Humans; Hy	1989
[Double-blind clinical study of the treatment of melasma with azelaic acid versus hydroquinone]. Medicina cutanea ibero-latino-americana, 1988, Volume: 16, Issue:6 Topics: Administration, Topical; Adolescent; Adult; Antineoplastic Agents; Clinical Trials as Topic; Dicarbo	1988

Article	Year
Liposomal azelaic acid 20% cream vs hydroquinone 4% cream as adjuvant to oral tranexamic acid in melasma: a comparative study. The Journal of dermatological treatment, 2022, Volume: 33, Issue:4 Topics: Adjuvants, Immunologic; Dermatologic Agents; Dicarboxylic Acids; Emollients; Female; Humans; Hydroqu	2022
Azelaic acid-loaded nanoemulsion with hyaluronic acid - a new strategy to treat hyperpigmentary skin disorders. Drug development and industrial pharmacy, 2019, Volume: 45, Issue:4 Topics: Administration, Cutaneous; Animals; Cell Survival; Dermatologic Agents; Dicarboxylic Acids; Drug Del	2019
A novel triple combination in treatment of melasma: Significant outcome with far less actives. Journal of cosmetic dermatology, 2019, Volume: 18, Issue:6 Topics: Administration, Cutaneous; Adult; Dermatologic Agents; Diagnostic Self Evaluation; Dicarboxylic Acid	2019
Combination of Oral Tranexamic Acid with Topical 3% Tranexamic Acid versus Oral Tranexamic Acid with Topical 20% Azelaic Acid in the Treatment of Melasma. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2019, Volume: 29, Issue:6 Topics: Administration, Cutaneous; Administration, Oral; Adult; Antifibrinolytic Agents; Combined Modality T	2019
Comparison of efficacy of products containing azelaic acid in melasma treatment. Journal of cosmetic dermatology, 2016, Volume: 15, Issue:3 Topics: Adult; Cosmeceuticals; Dermatologic Agents; Dicarboxylic Acids; Drug Combinations; Female; Humans; M	2016
Therapeutical approaches in melasma. Dermatologic clinics, 2007, Volume: 25, Issue:3 Topics: Chemexfoliation; Cosmetics; Dermatologic Agents; Dicarboxylic Acids; Drug Combinations; Humans; Hydr	2007
Beneficial effect of 15% azelaic acid cream on acne vulgaris. The British journal of dermatology, 1983, Volume: 109, Issue:1 Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Dicarboxylic Acids; Female; Humans; Male;	1983
[Depigmenting chemical agents]. Annales de dermatologie et de venereologie, 1986, Volume: 113, Issue:8 Topics: Dicarboxylic Acids; Humans; Hydroquinones; Melanosis; Skin Pigmentation	1986

azelaic acid and Chloasma

Research Excerpts

Research

Studies (24)

Authors

Clinical Trials (6)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Chang, YF	1
Lee, TL	1
Oyerinde, O	1
Desai, SR	1
Aljabban, A	1
Bay, CP	1
Bain, PA	1
Chung, HJ	1
King, S	1
Campbell, J	1
Rowe, R	1
Daly, ML	1
Moncrieff, G	1
Maybury, C	1
Akl, EM	1
Jacobus Berlitz, S	1
De Villa, D	1
Maschmann Inácio, LA	1
Davies, S	1
Zatta, KC	1
Guterres, SS	1
Külkamp-Guerreiro, IC	1
Pekmezci, E	1
Malik, F	1
Hanif, MM	1
Mustafa, G	1
Schulte, BC	1
Wu, W	1
Rosen, T	1
Mazurek, K	1
Pierzchała, E	1
Dayal, S	1
Sahu, P	1
Dua, R	1
Sheth, VM	1
Pandya, AG	1
Farshi, S	1
Sarkar, R	1
Bhalla, M	1
Kanwar, AJ	1
Cayce, KA	1
McMichael, AJ	1
Feldman, SR	1
Del Rosso, JQ	1
Gupta, AK	1
Gover, MD	1
Nouri, K	1
Taylor, S	1
Erbil, H	1
Sezer, E	1
Taştan, B	1
Arca, E	1
Kurumlu, Z	1
Prignano, F	1
Ortonne, JP	2
Buggiani, G	1
Lotti, T	1
Nazzaro-Porro, M	1
Passi, S	1
Picardo, M	1
Breathnach, A	1
Clayton, R	1
Zina, G	1
Grimes, PE	1
Breathnach, AS	1
Baliña, LM	1
Graupe, K	2
Verallo-Rowell, VM	1
Verallo, V	1
Lopez-Villafuerte, L	1
Garcia-Lopez, M	1
Piquero Martín, J	1
Rothe de Arocha, J	1
Beniamini Loker, D	1