Page last updated: 2024-10-23

azelaic acid and Acne

azelaic acid has been researched along with Acne in 100 studies

nonanedioic acid : An alpha,omega-dicarboxylic acid that is heptane substituted at positions 1 and 7 by carboxy groups.

Research Excerpts

ExcerptRelevanceReference
"This review is an update of the literature accumulated over the past 6 years following the original observation that topically applied azelaic acid, a non-toxic C9 dicarboxylic acid, has a beneficial therapeutic effect on acne vulgaris."10.16[Azelaic acid in the treatment of acne]. ( Breathnach, AS; Nazzaro-Porro, M; Passi, S; Picardo, M; Zina, G, 1989)
"Evaluate the efficacy and tolerance of the test product containing Myrtus communis extract and azelaic acid compared with a light moisturizing cream (LCM) in adult females in the acne maintenance phase."9.69The usefulness of a dermocosmetic containing Myrtus communis extract and azelaic acid for maintenance phase of adult female acne: Results from a randomized exploratory investigator-blinded comparative study. ( Andrade, LSM; Bacquey, A; Bagatin, E; Baradat, S; Lauze, C; Mengeaud, V; Miot, HA; Rocha, MA; Soares, JLM; Thouvenin, MD, 2023)
"Topical azelaic acid (AA) is indicated for acne and rosacea, but there is some evidence for its use for other dermatological conditions."9.41A systematic review to evaluate the efficacy of azelaic acid in the management of acne, rosacea, melasma and skin aging. ( Campbell, J; Daly, ML; King, S; Maybury, C; Moncrieff, G; Rowe, R, 2023)
" This study aims to explore the differences in the effectiveness of azelaic and pyruvic acid peels in the treatment of acne vulgaris."9.34A comparison of the effectiveness of azelaic and pyruvic acid peels in the treatment of female adult acne: a randomized controlled trial. ( Chilicka, K; Dzieńdziora-Urbińska, I; Rogowska, AM; Szyguła, R; Taradaj, J, 2020)
" Azelaic acid cream has been previously approved for acne vulgaris, thus azelaic acid foam may be a viable treatment option for truncal acne."9.24The Efficacy and Safety of Azelaic Acid 15% Foam in the Treatment of Truncal Acne Vulgaris. ( Del Rosso, JQ; Hoffman, LK; Kircik, LH, 2017)
"Treatment with azelaic acid 20 % cream significantly improves acne severity and disease-related QoL in adult women."9.22Azelaic acid 20 % cream: effects on quality of life and disease severity in adult female acne patients. ( Auer-Grumbach, P; Berghammer, G; Kainz, JT; Lackner, V; Perl-Convalexius, S; Popa, R; Wolfesberger, B, 2016)
"To compare the efficacy, tolerability and safety of a combination of benzoyl peroxide 3% and clindamycin 1% (BPO + CLN) with azelaic acid 20% (AzA) for the topical treatment of mild-to-moderate acne vulgaris."9.22A multicentre, randomized, single-blind, parallel-group study comparing the efficacy and tolerability of benzoyl peroxide 3%/clindamycin 1% with azelaic acid 20% in the topical treatment of mild-to-moderate acne vulgaris. ( Hennig, M; Ress, C; Schaller, M; Sebastian, M; Seidel, D, 2016)
"Azelaic acid gel is an effective topical monotherapy for mild-to-moderate acne vulgaris; its new gel form is an enrichment of acne therapy."9.11[Azelaic acid 15% gel in the treatment of acne vulgaris. Combined results of two double-blind clinical comparative studies]. ( Gollnick, HP; Graupe, K; Zaumseil, RP, 2004)
"20% azelaic acid cream was compared clinically with it vehicle in a 3-month double-blind study of 92 patients with moderate inflammatory acne."9.06Clinical studies of 20% azelaic acid cream in the treatment of acne vulgaris. Comparison with vehicle and topical tretinoin. ( Graupe, K; Katsambas, A; Stratigos, J, 1989)
"In a series of investigations using 20% azelaic acid cream as a therapy for acne, it was found that the treatment, compared with its placebo, significantly reduced inflamed lesions after 1 month and non-inflamed lesions after 2 months."9.06Clinical and laboratory studies on treatment with 20% azelaic acid cream for acne. ( Cunliffe, WJ; Holland, KT, 1989)
"20% azelaic acid cream was compared clinically with its vehicle in a 3-month double-blind study of 92 patients with moderate inflammatory acne."9.06[National and international clinical experiences with azelaic acid cream in the treatment of comedo acne]. ( Giannotti, B, 1989)
"In a series of investigation using 20% azelaic acid as a therapy for acne, it was found that the treatment, compared with most common therapies (benzoylperoxide, oral tetracycline) significantly reduced inflamed lesions in papulo-pustular acne."9.06[National and international experiences with azelaic acid cream in the treatment of papulo-pustular acne]. ( Caputo, R; Cavicchini, S, 1989)
"Preliminary clinical studies (2) proved the effectiveness of topical azelaic acid (AZA) in the treatment of acne vulgaris."9.06Long-term treatment of acne with 20% azelaic acid cream. ( Caputo, R; Cavicchini, S, 1989)
"Topical azelaic acid and oral tetracycline were compared in a 6-month double-blind study for treatment of acne vulgaris in 45 male subjects with clinical acne."9.06Topical azelaic acid and the treatment of acne: a clinical and laboratory comparison with oral tetracycline. ( Bladon, PT; Burke, BM; Cunliffe, WJ; Forster, RA; Holland, KT; King, K, 1986)
"To assess the effects of topical treatments (azelaic acid, salicylic acid, nicotinamide, zinc, alpha-hydroxy acid, and sulphur) for acne."9.05Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne. ( Liu, GJ; Liu, H; Liu, L; Peinemann, F; Sang, H; Xia, J; Yu, H, 2020)
" In terms of treatment response (measured using participants' global self-assessment of acne improvement, PGA), azelaic acid was probably less effective than benzoyl peroxide (RR = 0."9.05Evidence-based topical treatments (azelaic acid, salicylic acid, nicotinamide, sulfur, zinc, and fruit acid) for acne: an abridged version of a Cochrane systematic review. ( Liu, G; Liu, H; Liu, L; Peinemann, F; Sang, H; Xia, J; Yu, H, 2020)
" Retinoids and azelaic acid have been widely used to treat acne."8.89Retinoids and azelaic acid to treat acne and hyperpigmentation in skin of color. ( Doig, S; Keri, J; Woolery-Lloyd, HC, 2013)
"Benzoyl peroxide was introduced as a basic treatment already in acne therapy 1934."8.86[Antibiotics, azelaic acid and benzoyl peroxide in topical acne therapy]. ( Degitz, K; Fluhr, JW, 2010)
"Azelaic acid (AzA) 15% gel is approved for the treatment of rosacea in the US, but also has approval for the treatment of acne vulgaris in many European countries where it has demonstrated success."8.84Versatility of azelaic acid 15% gel in treatment of inflammatory acne vulgaris. ( Thiboutot, D, 2008)
"Benzoyl peroxide (BPO) was introduced in the treatment of acne in 1934."8.83[Acne therapy with topical benzoyl peroxide, antibiotics and azelaic acid]. ( Fluhr, JW; Worret, WI, 2006)
"Azelaic acid 20% cream (AZELEX) is a novel anti-acne agent with antimicrobial activity and keratinization-normalizing properties."8.79Azelaic acid 20% cream (AZELEX) and the medical management of acne vulgaris. ( Gibson, JR, 1997)
"Azelaic acid is another option for the topical treatment of mild to moderate inflammatory acne vulgaris."8.79Azelaic acid therapy for acne. ( Mackrides, PS; Shaughnessy, AF, 1996)
"Azelaic acid is a naturally occurring saturated dicarboxylic acid which, on topical application (usually as a 20% cream), has been shown to be effective in the treatment of comedonal acne and inflammatory (papulopustular, nodular and nodulocystic) acne, as well as various cutaneous hyperpigmentary disorders characterised by hyperactive/abnormal melanocyte function, including melasma and, possibly, lentigo maligna."8.78Azelaic acid. A review of its pharmacological properties and therapeutic efficacy in acne and hyperpigmentary skin disorders. ( Fitton, A; Goa, KL, 1991)
"The current work was aimed at the development of a topical drug delivery system for azelaic acid (AzA) for acne treatment."8.31The Formulation and Evaluation of Deep Eutectic Vehicles for the Topical Delivery of Azelaic Acid for Acne Treatment. ( Al-Adham, I; Al-Akayleh, F; Al-Ani, I; Al-Remawi, M; Ali, HHM; Khanfar, M; Luhaibi, DK; Nasereddin, J; Qinna, NA; Shalan, N, 2023)
"Azelaic acid (AzA) is a USFDA bioactive prescribed against acne vulgaris."8.12Hydrogel composite containing azelaic acid and tea tree essential oil as a therapeutic strategy for Propionibacterium and testosterone-induced acne. ( Aljabali, AAA; Bakshi, HA; Bisht, A; Chakraborty, A; Chellappan, DK; Dev, K; Dhiman, T; Dua, K; Gupta, G; Hemrajani, C; Negi, P; Nidhi, P; Rathore, C; Rolta, R; Sourirajan, A; Tambuwala, MM; Upadhyay, N, 2022)
"In this study, hydrogels containing azelaic acid were developed using chitosan or HPMC (1-7%) for local treatment of acne vulgaris."8.12Azelaic acid loaded chitosan and HPMC based hydrogels for treatment of acne: formulation, characterization, ( Arpa, MD; Erim, ÜC; Hoş, A; Seçen, İM; Üstündağ Okur, N, 2022)
"To overcome the poor solubility, skin irritation, and low permeability of azelaic acid (AZA) existed on the marketed formulations, a co-drug principle via matrine (MAT) was adopted to prepare anti-acne dissolving microneedles (DMNs)."8.02Acid-base combination principles for preparation of anti-acne dissolving microneedles loaded with azelaic acid and matrine. ( Gao, Y; Xing, M; Yang, G; Zhang, S, 2021)
" Chemical peeling is a well-known option in the treatment of acne vulgaris, but little is known about azelaic acid (AZA) peels."8.02Efficacy of 30% azelaic acid peel in the nonpharmacological treatment of facial acne. ( Budzisz, E; Erkiert-Polguj, A; Szymańska, A, 2021)
"To examine the efficacy and safety of azelaic acid 15% foam in the treatment of moderate-to-severe facial acne Methods: Twenty subjects with moderate-to-severe facial acne vulgaris were enrolled in this two-center, open-label pilot study."7.88The Efficacy and Safety of Azelaic Acid 15% Foam in the Treatment of Facial Acne Vulgaris. ( Chen, T; Harper, JC; Hashim, PW; Kircik, LH, 2018)
"Azelaic acid (AzA) is used in the treatment of acne."7.79Development and evaluation of a novel topical treatment for acne with azelaic acid-loaded nanoparticles. ( Ascensão, L; Baptista, M; Candeias, S; Gomes, A; Martinho, N; Pinto, P; Reis, CP; Rijo, P, 2013)
"Thirty patients of either sex (23 M, 7 F) ranging in age between 16 and 36 years, affected of acne vulgaris, were given 20% azelaic acid cream over a period of 6 months."7.67[Topical therapeutic action of azelaic acid in polymorphous acne]. ( Florio, T; Petruzzellis, V; Troccoli, T, 1989)
"Patients treated with azelaic acid (15%) cream for chloasma reported simultaneous improvement of acne lesions within the treated areas."7.66Beneficial effect of 15% azelaic acid cream on acne vulgaris. ( Breathnach, A; Clayton, R; Nazzaro-Porro, M; Passi, S; Picardo, M; Zina, G, 1983)
"AzA15% gel is a safe and effective treatment and maintenance treatment of female adult acne with non-inferior efficacy to AD 0."6.80A randomized investigator-blind parallel-group study to assess efficacy and safety of azelaic acid 15% gel vs. adapalene 0.1% gel in the treatment and maintenance treatment of female adult acne. ( Gollnick, H; Kropf, S; Lux, A; Papakonstantinou, E; Thielitz, A; Wiede, A, 2015)
"Acne vulgaris is a common problem, particularly among adolescents, which is usually resistant to monotherapy."6.75Combination of azelaic acid 5% and erythromycin 2% in the treatment of acne vulgaris. ( Ajami, M; Babakoohi, S; Firooz, A; Habibey, R; Nassiri-Kashani, M; Pazoki-Toroudi, H; Rahshenas, M; Shizarpour, M; Tabatabaie, H, 2010)
"This review is an update of the literature accumulated over the past 6 years following the original observation that topically applied azelaic acid, a non-toxic C9 dicarboxylic acid, has a beneficial therapeutic effect on acne vulgaris."6.16[Azelaic acid in the treatment of acne]. ( Breathnach, AS; Nazzaro-Porro, M; Passi, S; Picardo, M; Zina, G, 1989)
"Evaluate the efficacy and tolerance of the test product containing Myrtus communis extract and azelaic acid compared with a light moisturizing cream (LCM) in adult females in the acne maintenance phase."5.69The usefulness of a dermocosmetic containing Myrtus communis extract and azelaic acid for maintenance phase of adult female acne: Results from a randomized exploratory investigator-blinded comparative study. ( Andrade, LSM; Bacquey, A; Bagatin, E; Baradat, S; Lauze, C; Mengeaud, V; Miot, HA; Rocha, MA; Soares, JLM; Thouvenin, MD, 2023)
"Topical azelaic acid (AA) is indicated for acne and rosacea, but there is some evidence for its use for other dermatological conditions."5.41A systematic review to evaluate the efficacy of azelaic acid in the management of acne, rosacea, melasma and skin aging. ( Campbell, J; Daly, ML; King, S; Maybury, C; Moncrieff, G; Rowe, R, 2023)
" This study aims to explore the differences in the effectiveness of azelaic and pyruvic acid peels in the treatment of acne vulgaris."5.34A comparison of the effectiveness of azelaic and pyruvic acid peels in the treatment of female adult acne: a randomized controlled trial. ( Chilicka, K; Dzieńdziora-Urbińska, I; Rogowska, AM; Szyguła, R; Taradaj, J, 2020)
"Azelaic acid is a competitive inhibitor of mitochondrial oxidoreductases and of 5 alpha-reductase, inhibiting the conversion of testosterone to 5-dehydrotestosterone."5.28[Mechanism of azelaic acid action in acne]. ( De Luca, C; Nazzaro-Porro, M; Passi, S; Picardo, M, 1989)
" Azelaic acid cream has been previously approved for acne vulgaris, thus azelaic acid foam may be a viable treatment option for truncal acne."5.24The Efficacy and Safety of Azelaic Acid 15% Foam in the Treatment of Truncal Acne Vulgaris. ( Del Rosso, JQ; Hoffman, LK; Kircik, LH, 2017)
"Treatment with azelaic acid 20 % cream significantly improves acne severity and disease-related QoL in adult women."5.22Azelaic acid 20 % cream: effects on quality of life and disease severity in adult female acne patients. ( Auer-Grumbach, P; Berghammer, G; Kainz, JT; Lackner, V; Perl-Convalexius, S; Popa, R; Wolfesberger, B, 2016)
"0001) number of patients demonstrated improvement over their previous acne treatment regimens after both 4 and 8 weeks of NicAzel (nicotinamide, azelaic acid, zinc, pyridoxine, copper, folic acid; Elorac Inc, Vernon Hills, IL) use."5.16Inflammatory acne management with a novel prescription dietary supplement. ( Akhavan, A; Day, D; Falcon, R; Iannotta, P; Janiga, A; Kallal, JE; Olansky, A; Shalita, AR; Singri, P, 2012)
"This study evaluated the efficacy and tolerability of treating mild-to-moderate facial acne using a new, hand-held, light-emitting diode blue light device in conjunction with a foam cleanser containing 5% glycolic acid and 2% salicylic acid plus a skin rebuilding serum containing 1."5.15Evaluation of self-treatment of mild-to-moderate facial acne with a blue light treatment system. ( Dhawan, S; Wheeland, RG, 2011)
"To evaluate the sebostatic effect of three anti-acneic ingredients (azelaic acid, adapalene and benzoyl peroxide) conveyed in cream and to determine whether there is a correlation with the therapeutic results."5.12Relationship between sebostatic activity, tolerability and efficacy of three topical drugs to treat mild to moderate acne. ( Bragadin, G; Patrone, P; Pillon, B; Stinco, G; Trotter, D, 2007)
"Azelaic acid gel is an effective topical monotherapy for mild-to-moderate acne vulgaris; its new gel form is an enrichment of acne therapy."5.11[Azelaic acid 15% gel in the treatment of acne vulgaris. Combined results of two double-blind clinical comparative studies]. ( Gollnick, HP; Graupe, K; Zaumseil, RP, 2004)
"In a series of investigations using 20% azelaic acid cream as a therapy for acne, it was found that the treatment, compared with its placebo, significantly reduced inflamed lesions after 1 month and non-inflamed lesions after 2 months."5.06Clinical and laboratory studies on treatment with 20% azelaic acid cream for acne. ( Cunliffe, WJ; Holland, KT, 1989)
"The effects of azelaic acid (AZA) on the epidermis of 47 individuals (12 with normal skin, 15 with seborrheic skin and 20 suffering from acne) and on in vitro cultured keratinocytes are reported."5.06Effects of azelaic acid on sebaceous gland, sebum excretion rate and keratinization pattern in human skin. An in vivo and in vitro study. ( Detmar, M; Gassmüller, J; Gollnick, H; Mayer-da-Silva, A; Müller, R; Orfanos, CE; Parry, A, 1989)
"20% azelaic acid cream was compared clinically with it vehicle in a 3-month double-blind study of 92 patients with moderate inflammatory acne."5.06Clinical studies of 20% azelaic acid cream in the treatment of acne vulgaris. Comparison with vehicle and topical tretinoin. ( Graupe, K; Katsambas, A; Stratigos, J, 1989)
"Topical azelaic acid and oral tetracycline were compared in a 6-month double-blind study for treatment of acne vulgaris in 45 male subjects with clinical acne."5.06Topical azelaic acid and the treatment of acne: a clinical and laboratory comparison with oral tetracycline. ( Bladon, PT; Burke, BM; Cunliffe, WJ; Forster, RA; Holland, KT; King, K, 1986)
"Preliminary clinical studies (2) proved the effectiveness of topical azelaic acid (AZA) in the treatment of acne vulgaris."5.06Long-term treatment of acne with 20% azelaic acid cream. ( Caputo, R; Cavicchini, S, 1989)
"In a series of investigation using 20% azelaic acid as a therapy for acne, it was found that the treatment, compared with most common therapies (benzoylperoxide, oral tetracycline) significantly reduced inflamed lesions in papulo-pustular acne."5.06[National and international experiences with azelaic acid cream in the treatment of papulo-pustular acne]. ( Caputo, R; Cavicchini, S, 1989)
"20% azelaic acid cream was compared clinically with its vehicle in a 3-month double-blind study of 92 patients with moderate inflammatory acne."5.06[National and international clinical experiences with azelaic acid cream in the treatment of comedo acne]. ( Giannotti, B, 1989)
" In terms of treatment response (measured using participants' global self-assessment of acne improvement, PGA), azelaic acid was probably less effective than benzoyl peroxide (RR = 0."5.05Evidence-based topical treatments (azelaic acid, salicylic acid, nicotinamide, sulfur, zinc, and fruit acid) for acne: an abridged version of a Cochrane systematic review. ( Liu, G; Liu, H; Liu, L; Peinemann, F; Sang, H; Xia, J; Yu, H, 2020)
"To assess the effects of topical treatments (azelaic acid, salicylic acid, nicotinamide, zinc, alpha-hydroxy acid, and sulphur) for acne."5.05Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne. ( Liu, GJ; Liu, H; Liu, L; Peinemann, F; Sang, H; Xia, J; Yu, H, 2020)
" Retinoids and azelaic acid have been widely used to treat acne."4.89Retinoids and azelaic acid to treat acne and hyperpigmentation in skin of color. ( Doig, S; Keri, J; Woolery-Lloyd, HC, 2013)
"Benzoyl peroxide was introduced as a basic treatment already in acne therapy 1934."4.86[Antibiotics, azelaic acid and benzoyl peroxide in topical acne therapy]. ( Degitz, K; Fluhr, JW, 2010)
"Benzoyl peroxide (BPO) was introduced in the treatment of acne in 1934."4.83[Acne therapy with topical benzoyl peroxide, antibiotics and azelaic acid]. ( Fluhr, JW; Worret, WI, 2006)
"Azelaic acid cream (20 percent) is a new topical treatment for acne with an additional therapeutic potential in rosacea and hyperpigmentation disorders."4.79Efficacy and safety of topical azelaic acid (20 percent cream): an overview of results from European clinical trials and experimental reports. ( Cunliffe, WJ; Gollnick, HP; Graupe, K; Zaumseil, RP, 1996)
"Azelaic acid is another option for the topical treatment of mild to moderate inflammatory acne vulgaris."4.79Azelaic acid therapy for acne. ( Mackrides, PS; Shaughnessy, AF, 1996)
"Azelaic acid is a naturally occurring saturated dicarboxylic acid which, on topical application (usually as a 20% cream), has been shown to be effective in the treatment of comedonal acne and inflammatory (papulopustular, nodular and nodulocystic) acne, as well as various cutaneous hyperpigmentary disorders characterised by hyperactive/abnormal melanocyte function, including melasma and, possibly, lentigo maligna."4.78Azelaic acid. A review of its pharmacological properties and therapeutic efficacy in acne and hyperpigmentary skin disorders. ( Fitton, A; Goa, KL, 1991)
"The current work was aimed at the development of a topical drug delivery system for azelaic acid (AzA) for acne treatment."4.31The Formulation and Evaluation of Deep Eutectic Vehicles for the Topical Delivery of Azelaic Acid for Acne Treatment. ( Al-Adham, I; Al-Akayleh, F; Al-Ani, I; Al-Remawi, M; Ali, HHM; Khanfar, M; Luhaibi, DK; Nasereddin, J; Qinna, NA; Shalan, N, 2023)
"In this study, hydrogels containing azelaic acid were developed using chitosan or HPMC (1-7%) for local treatment of acne vulgaris."4.12Azelaic acid loaded chitosan and HPMC based hydrogels for treatment of acne: formulation, characterization, ( Arpa, MD; Erim, ÜC; Hoş, A; Seçen, İM; Üstündağ Okur, N, 2022)
"Azelaic acid (AzA) is a USFDA bioactive prescribed against acne vulgaris."4.12Hydrogel composite containing azelaic acid and tea tree essential oil as a therapeutic strategy for Propionibacterium and testosterone-induced acne. ( Aljabali, AAA; Bakshi, HA; Bisht, A; Chakraborty, A; Chellappan, DK; Dev, K; Dhiman, T; Dua, K; Gupta, G; Hemrajani, C; Negi, P; Nidhi, P; Rathore, C; Rolta, R; Sourirajan, A; Tambuwala, MM; Upadhyay, N, 2022)
"To overcome the poor solubility, skin irritation, and low permeability of azelaic acid (AZA) existed on the marketed formulations, a co-drug principle via matrine (MAT) was adopted to prepare anti-acne dissolving microneedles (DMNs)."4.02Acid-base combination principles for preparation of anti-acne dissolving microneedles loaded with azelaic acid and matrine. ( Gao, Y; Xing, M; Yang, G; Zhang, S, 2021)
" Chemical peeling is a well-known option in the treatment of acne vulgaris, but little is known about azelaic acid (AZA) peels."4.02Efficacy of 30% azelaic acid peel in the nonpharmacological treatment of facial acne. ( Budzisz, E; Erkiert-Polguj, A; Szymańska, A, 2021)
"To examine the efficacy and safety of azelaic acid 15% foam in the treatment of moderate-to-severe facial acne Methods: Twenty subjects with moderate-to-severe facial acne vulgaris were enrolled in this two-center, open-label pilot study."3.88The Efficacy and Safety of Azelaic Acid 15% Foam in the Treatment of Facial Acne Vulgaris. ( Chen, T; Harper, JC; Hashim, PW; Kircik, LH, 2018)
"Azelaic acid is a dicarboxylic acid compound used in treatment of acne vulgaris."3.85A prodrug approach to enhance azelaic acid percutaneous availability. ( Al-Bakri, AG; Al-Marabeh, S; Alzweiri, M; Khalil, E; Khanfar, M, 2017)
"The aim of this study was to evaluate a formulation made of poly(lactide-co-glycolide) (PLGA) nanoparticles containing azelaic acid for potential acne treatment."3.80Design of polymeric nanoparticles and its applications as drug delivery systems for acne treatment. ( Fernandes, AS; Martinho, N; Reis, CP; Roberto, A; Rosado, C, 2014)
"Azelaic acid (AzA) is used in the treatment of acne."3.79Development and evaluation of a novel topical treatment for acne with azelaic acid-loaded nanoparticles. ( Ascensão, L; Baptista, M; Candeias, S; Gomes, A; Martinho, N; Pinto, P; Reis, CP; Rijo, P, 2013)
"Azelaic acid (AzA), a nine-carbon dicarboxylic acid, is an agent for the topical treatment of acne."3.76Azelaic acid modulates the inflammatory response in normal human keratinocytes through PPARgamma activation. ( Aspite, N; Camera, E; Cardinali, G; Graupe, K; Izzo, E; Mastrofrancesco, A; Ottaviani, M; Picardo, M; Zouboulis, CC, 2010)
"Thirty patients of either sex (23 M, 7 F) ranging in age between 16 and 36 years, affected of acne vulgaris, were given 20% azelaic acid cream over a period of 6 months."3.67[Topical therapeutic action of azelaic acid in polymorphous acne]. ( Florio, T; Petruzzellis, V; Troccoli, T, 1989)
"Patients treated with azelaic acid (15%) cream for chloasma reported simultaneous improvement of acne lesions within the treated areas."3.66Beneficial effect of 15% azelaic acid cream on acne vulgaris. ( Breathnach, A; Clayton, R; Nazzaro-Porro, M; Passi, S; Picardo, M; Zina, G, 1983)
"Acne and rosacea are common inflammatory skin conditions present in numerous racial and ethnic groups."2.82Acne and rosacea in skin of colour. ( Maruthappu, T; Taylor, M, 2022)
"Azelaic acid has numerous pharmacological uses in dermatology."2.82The versatility of azelaic acid in dermatology. ( Al-Niaimi, F; Ali, FR; Searle, T, 2022)
"AzA15% gel is a safe and effective treatment and maintenance treatment of female adult acne with non-inferior efficacy to AD 0."2.80A randomized investigator-blind parallel-group study to assess efficacy and safety of azelaic acid 15% gel vs. adapalene 0.1% gel in the treatment and maintenance treatment of female adult acne. ( Gollnick, H; Kropf, S; Lux, A; Papakonstantinou, E; Thielitz, A; Wiede, A, 2015)
"Recognition that acne is an inflammatory condition, not an infectious one, has led to a call for reduction in antibiotic use."2.61An Overview of Acne Therapy, Part 1: Topical therapy, Oral Antibiotics, Laser and Light Therapy, and Dietary Interventions. ( Baldwin, HE; Marson, JW, 2019)
"Azelaic acid is a complex molecule with many diverse activities."2.52Azelaic Acid: Evidence-based Update on Mechanism of Action and Clinical Application. ( Rosen, T; Schulte, BC; Wu, W, 2015)
"Acne is a common skin disorder that can be problematic for adults as well as for adolescents."2.50Azelaic acid: Properties and mode of action. ( Hegel, JK; Sieber, MA, 2014)
"Acne vulgaris is a very common inflammatory skin disease originating from the pilosebaceous unit."2.47Acne vulgaris in children and adolescents. ( Mempel, M; Schnopp, C, 2011)
"Azelaic acid (AzA) is a naturally occurring dicarboxylic acid that has a long and complex history in the treatment of skin disorders."2.43The evolution of azelaic acid. ( Fleischer, AB, 2006)
"The management of acne is a gratifying experience."2.43Managing acne vulgaris effectively. ( Goodman, G, 2006)
"Acne is a common problem in adolescents and young adults."2.41Topical therapy for acne. ( Russell, JJ, 2000)
"Though acne is not generally cured, treatment can reduce the severity and frequency of outbreaks, lessen discomfort from inflamed lesions, improve appearance, and prevent or minimize scarring, thereby averting or ameliorating potentially serious adverse psychosocial effects."2.40Acne vulgaris: a treatment update. ( Quan, MA; Strick, R; Usatine, RP, 1998)
"Acne is one of the most common diseases in dermatology."2.40Advances and perspectives in acne therapy. ( Jansen, T; Plewig, G, 1997)
"Azelaic acid also has significant antimicrobial activity relevant to its efficacy in acne vulgaris."2.39Rationale for the development of new topical treatments for acne vulgaris. ( Gibson, JR, 1996)
" Patients were treated with a supplement based on biotin and 3 strains of lactic ferments, combined with a topical gel product (azelaic-acid, hydroxypinacolone retinoate, and α-hydroxy acids)."1.72Probiotic supplement combined with topical therapy in the treatment of mild to moderate acne: results from an Italian single centre interventional study. ( Annunziata, MC; Cacciapuoti, S; Fabbrocini, G; Marasca, C; Ruggiero, A, 2022)
"Acne vulgaris is a pervasive inflammatory disorder of the skin, with multiple etiologies and treatment options."1.40Acne vulgaris in the context of complex medical co-morbities: the management of severe acne vulgaris in a female with retinitis pigmentosa - utilizing pulse dye laser in conjunction with medical therapy. ( Keck, L; Shariff, A; Zlotoff, B, 2014)
"Acne should be treated during pregnancy to prevent worsening, scarring, secondary infection or psychological impairment of the mother."1.39[Acne therapy in pregnancy]. ( Bayerl, C, 2013)
"Azelaic acid has strong antibacterial potency without inducing bacterial resistance similar to benzoyl peroxide."1.30Topical drug treatment in acne. ( Gollnick, H; Schramm, M, 1998)
"Azelaic acid is a competitive inhibitor of mitochondrial oxidoreductases and of 5 alpha-reductase, inhibiting the conversion of testosterone to 5-dehydrotestosterone."1.28[Mechanism of azelaic acid action in acne]. ( De Luca, C; Nazzaro-Porro, M; Passi, S; Picardo, M, 1989)

Research

Studies (100)

TimeframeStudies, this research(%)All Research%
pre-199021 (21.00)18.7374
1990's18 (18.00)18.2507
2000's17 (17.00)29.6817
2010's29 (29.00)24.3611
2020's15 (15.00)2.80

Authors

AuthorsStudies
Maruthappu, T1
Taylor, M1
Szymańska, A2
Budzisz, E2
Erkiert-Polguj, A2
Bisht, A2
Hemrajani, C2
Rathore, C2
Dhiman, T1
Rolta, R2
Upadhyay, N2
Nidhi, P2
Gupta, G2
Dua, K2
Chellappan, DK2
Dev, K2
Sourirajan, A2
Chakraborty, A1
Aljabali, AAA1
Bakshi, HA2
Negi, P2
Tambuwala, MM2
Aljabali, AA1
Arpa, MD1
Seçen, İM1
Erim, ÜC1
Hoş, A1
Üstündağ Okur, N1
Marasca, C1
Ruggiero, A1
Cacciapuoti, S1
Fabbrocini, G1
Annunziata, MC1
Bagatin, E2
Thouvenin, MD1
Bacquey, A1
Baradat, S1
Lauze, C1
Mengeaud, V1
Soares, JLM1
Andrade, LSM1
Miot, HA1
Rocha, MA1
King, S1
Campbell, J1
Rowe, R1
Daly, ML1
Moncrieff, G1
Maybury, C1
Luhaibi, DK1
Ali, HHM1
Al-Ani, I1
Shalan, N1
Al-Akayleh, F1
Al-Remawi, M1
Nasereddin, J1
Qinna, NA1
Al-Adham, I1
Khanfar, M2
Liu, H2
Yu, H2
Xia, J2
Liu, L2
Liu, GJ1
Sang, H2
Peinemann, F2
Chilicka, K1
Rogowska, AM1
Szyguła, R1
Dzieńdziora-Urbińska, I1
Taradaj, J1
Searle, T1
Ali, FR1
Al-Niaimi, F1
Liu, G1
Xing, M1
Yang, G1
Zhang, S1
Gao, Y1
Hoffman, LK1
Del Rosso, JQ1
Kircik, LH3
Melnik, BC3
Hashim, PW1
Chen, T1
Harper, JC1
Marson, JW1
Baldwin, HE1
Bayerl, C1
Reis, CP2
Martinho, N2
Rosado, C1
Fernandes, AS1
Roberto, A1
Woolery-Lloyd, HC1
Keri, J1
Doig, S1
Gomes, A1
Rijo, P1
Candeias, S1
Pinto, P1
Baptista, M1
Ascensão, L1
Schmitz, G2
Sieber, MA1
Hegel, JK1
Vargas-Diez, E1
Hofmann, MA1
Bravo, B1
Malgazhdarova, G1
Katkhanova, OA1
Yutskovskaya, Y1
Shariff, A1
Keck, L1
Zlotoff, B1
Thielitz, A1
Lux, A1
Wiede, A1
Kropf, S1
Papakonstantinou, E1
Gollnick, H5
Schulte, BC1
Wu, W1
Rosen, T1
Albuquerque, RG1
da Rocha, MA1
Hirotsu, C1
Hachul, H1
Tufik, S1
Andersen, ML1
Schaller, M1
Sebastian, M1
Ress, C1
Seidel, D1
Hennig, M1
Al-Marabeh, S1
Khalil, E1
Al-Bakri, AG1
Alzweiri, M1
Samycia, M1
Lam, JM1
Kainz, JT1
Berghammer, G1
Auer-Grumbach, P1
Lackner, V1
Perl-Convalexius, S1
Popa, R1
Wolfesberger, B1
Zouboulis, CC2
Choi, YS1
Suh, HS1
Yoon, MY1
Min, SU1
Kim, JS1
Jung, JY1
Lee, DH1
Suh, DH1
Pazoki-Toroudi, H2
Nassiri-Kashani, M2
Tabatabaie, H1
Ajami, M2
Habibey, R1
Shizarpour, M1
Babakoohi, S1
Rahshenas, M1
Firooz, A2
Fluhr, JW2
Degitz, K1
Mastrofrancesco, A1
Ottaviani, M1
Aspite, N1
Cardinali, G1
Izzo, E1
Graupe, K7
Camera, E1
Picardo, M4
Merkviladze, N1
Gaidamashvili, T1
Tushurashvili, P1
Ekaladze, E1
Jojua, N1
Nilforoushzadeh, MA1
Jaffary, F1
Aboutaleb, N1
Wheeland, RG1
Dhawan, S1
Schnopp, C1
Mempel, M1
Shalita, AR1
Falcon, R1
Olansky, A1
Iannotta, P1
Akhavan, A1
Day, D1
Janiga, A1
Singri, P1
Kallal, JE1
Liao, DC1
Purdy, S2
Callender, VD1
Gollnick, HP2
Zaumseil, RP2
Fleischer, AB1
Worret, WI1
Goodman, G1
Stinco, G1
Bragadin, G1
Trotter, D1
Pillon, B1
Patrone, P1
Alevizos, A1
Mariolis, A1
Larios, G1
Thiboutot, D1
Nazzaro-Porro, M5
Passi, S4
Breathnach, A1
Clayton, R1
Zina, G3
Marsden, JR1
Shuster, S1
Breathnach, AS2
Nguyen, QH1
Bui, TP1
Bojar, RA2
Cutcliffe, AG1
Cunliffe, WJ4
Holland, KT4
Gibson, JR2
Lowe, NJ1
Oh, CW1
Myung, KB1
Mackrides, PS1
Shaughnessy, AF1
Jansen, T1
Plewig, G1
Usatine, RP2
Quan, MA1
Strick, R1
Schramm, M2
Russell, JJ1
Webster, G1
Koczorek, M1
Shemer, A1
Weiss, G1
Amichai, B1
Kaplan, B1
Trau, H1
Fitton, A1
Goa, KL1
Angius, AG1
Barbareschi, M1
Cattaneo, M1
Monti, M1
Caputo, R3
Mayer-da-Silva, A1
Detmar, M1
Gassmüller, J1
Parry, A1
Müller, R1
Orfanos, CE2
Töpert, M1
Rach, P1
Siegmund, F1
Katsambas, A1
Stratigos, J1
Cavicchini, S2
Hjorth, N1
De Luca, C1
Giannotti, B1
Colonna, SM1
Troccoli, T1
Florio, T1
Petruzzellis, V1
Gassmueller, H1
Bladon, PT1
Burke, BM1
Forster, RA1
King, K1
Leeming, JP1
Auld, J1

Reviews

37 reviews available for azelaic acid and Acne

ArticleYear
Acne and rosacea in skin of colour.
    Clinical and experimental dermatology, 2022, Volume: 47, Issue:2

    Topics: Acne Vulgaris; Adapalene; Diagnosis, Differential; Dicarboxylic Acids; Humans; Racial Groups; Rosace

2022
A systematic review to evaluate the efficacy of azelaic acid in the management of acne, rosacea, melasma and skin aging.
    Journal of cosmetic dermatology, 2023, Volume: 22, Issue:10

    Topics: Acne Vulgaris; Dermatologic Agents; Erythema; Humans; Melanosis; Rosacea; Skin Aging; Treatment Outc

2023
Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne.
    The Cochrane database of systematic reviews, 2020, 05-01, Volume: 5

    Topics: Acne Vulgaris; Adapalene; Adolescent; Adult; Anti-Bacterial Agents; Benzoyl Peroxide; Bias; Child; C

2020
The versatility of azelaic acid in dermatology.
    The Journal of dermatological treatment, 2022, Volume: 33, Issue:2

    Topics: Acne Vulgaris; Dermatologic Agents; Dermatology; Dicarboxylic Acids; Humans; Male; Rosacea

2022
Evidence-based topical treatments (azelaic acid, salicylic acid, nicotinamide, sulfur, zinc, and fruit acid) for acne: an abridged version of a Cochrane systematic review.
    Journal of evidence-based medicine, 2020, Volume: 13, Issue:4

    Topics: Acne Vulgaris; Administration, Cutaneous; Dermatologic Agents; Dicarboxylic Acids; Fruit; Glycolates

2020
p53: key conductor of all anti-acne therapies.
    Journal of translational medicine, 2017, 09-19, Volume: 15, Issue:1

    Topics: Acne Vulgaris; Dicarboxylic Acids; Humans; Isotretinoin; Models, Biological; Photochemotherapy; Tetr

2017
An Overview of Acne Therapy, Part 1: Topical therapy, Oral Antibiotics, Laser and Light Therapy, and Dietary Interventions.
    Dermatologic clinics, 2019, Volume: 37, Issue:2

    Topics: Acne Vulgaris; Administration, Cutaneous; Administration, Oral; Anti-Bacterial Agents; Combined Moda

2019
Retinoids and azelaic acid to treat acne and hyperpigmentation in skin of color.
    Journal of drugs in dermatology : JDD, 2013, Volume: 12, Issue:4

    Topics: Acne Vulgaris; Dermatologic Agents; Dicarboxylic Acids; Humans; Hyperpigmentation; Retinoids; Skin P

2013
Azelaic acid: Properties and mode of action.
    Skin pharmacology and physiology, 2014, Volume: 27 Suppl 1

    Topics: Acne Vulgaris; Anti-Bacterial Agents; Anti-Inflammatory Agents; Dermatologic Agents; Dicarboxylic Ac

2014
Azelaic Acid: Evidence-based Update on Mechanism of Action and Clinical Application.
    Journal of drugs in dermatology : JDD, 2015, Volume: 14, Issue:9

    Topics: Acne Vulgaris; Alopecia Areata; Dermatitis, Perioral; Dermatologic Agents; Dicarboxylic Acids; Facia

2015
Anti-acne agents attenuate FGFR2 signal transduction in acne.
    The Journal of investigative dermatology, 2009, Volume: 129, Issue:8

    Topics: Acne Vulgaris; alpha-MSH; Androgen Antagonists; Benzoyl Peroxide; Dicarboxylic Acids; Erythromycin;

2009
[Antibiotics, azelaic acid and benzoyl peroxide in topical acne therapy].
    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2010, Volume: 8 Suppl 1

    Topics: Acne Vulgaris; Administration, Topical; Anti-Bacterial Agents; Benzoyl Peroxide; Clindamycin; Dermat

2010
Acne vulgaris in children and adolescents.
    Minerva pediatrica, 2011, Volume: 63, Issue:4

    Topics: Acne Vulgaris; Administration, Cutaneous; Adolescent; Anti-Bacterial Agents; Benzoyl Peroxide; Child

2011
Management of acne.
    The Journal of family practice, 2003, Volume: 52, Issue:1

    Topics: Acne Vulgaris; Adapalene; Administration, Oral; Administration, Topical; Algorithms; Anti-Bacterial

2003
Acne vulgaris.
    Clinical evidence, 2005, Issue:13

    Topics: Acne Vulgaris; Adapalene; Anti-Bacterial Agents; Benzoyl Peroxide; Clindamycin; Dermatologic Agents;

2005
Considerations for treating acne in ethnic skin.
    Cutis, 2005, Volume: 76, Issue:2 Suppl

    Topics: Acne Keloid; Acne Vulgaris; Black People; Cosmetics; Dicarboxylic Acids; Drug Therapy, Combination;

2005
The evolution of azelaic acid.
    Cutis, 2006, Volume: 77, Issue:2 Suppl

    Topics: Acne Vulgaris; Dermatologic Agents; Dicarboxylic Acids; Humans; Hyperpigmentation; Rosacea; Skin Dis

2006
[Acne therapy with topical benzoyl peroxide, antibiotics and azelaic acid].
    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2006, Volume: 4, Issue:4

    Topics: Acne Vulgaris; Administration, Topical; Anti-Bacterial Agents; Benzoyl Peroxide; Dermatologic Agents

2006
Managing acne vulgaris effectively.
    Australian family physician, 2006, Volume: 35, Issue:9

    Topics: Acne Vulgaris; Administration, Oral; Administration, Topical; Adolescent; Adult; Androgens; Anti-Bac

2006
Acne vulgaris.
    Clinical evidence, 2006, Issue:15

    Topics: Acne Vulgaris; Adapalene; Anti-Bacterial Agents; Benzoyl Peroxide; Clindamycin; Dermatologic Agents;

2006
Versatility of azelaic acid 15% gel in treatment of inflammatory acne vulgaris.
    Journal of drugs in dermatology : JDD, 2008, Volume: 7, Issue:1

    Topics: Acne Vulgaris; Dermatologic Agents; Dicarboxylic Acids; Dose-Response Relationship, Drug; Gels; Huma

2008
Azelaic acid.
    The British journal of dermatology, 1984, Volume: 111, Issue:1

    Topics: Acne Vulgaris; Antineoplastic Agents; Dicarboxylic Acids; Humans; Melanoma; Nevus, Pigmented; Oxidat

1984
Azelaic acid: pharmacokinetic and pharmacodynamic properties and its therapeutic role in hyperpigmentary disorders and acne.
    International journal of dermatology, 1995, Volume: 34, Issue:2

    Topics: Acne Vulgaris; Animals; Anti-Infective Agents; Antineoplastic Agents; Cell Division; Cell Survival;

1995
Azelaic acid--a new topical treatment for acne.
    Drug and therapeutics bulletin, 1993, Jun-21, Volume: 31, Issue:13

    Topics: Acne Vulgaris; Administration, Topical; Dermatologic Agents; Dicarboxylic Acids; Humans; Randomized

1993
Rationale for the development of new topical treatments for acne vulgaris.
    Cutis, 1996, Volume: 57, Issue:1 Suppl

    Topics: Acne Vulgaris; Administration, Topical; Carboxylic Acids; Dermatologic Agents; Dicarboxylic Acids; H

1996
Efficacy and safety of topical azelaic acid (20 percent cream): an overview of results from European clinical trials and experimental reports.
    Cutis, 1996, Volume: 57, Issue:1 Suppl

    Topics: Acne Vulgaris; Administration, Topical; Clinical Trials as Topic; Dermatologic Agents; Dicarboxylic

1996
Azelaic acid therapy for acne.
    American family physician, 1996, Volume: 54, Issue:8

    Topics: Acne Vulgaris; Administration, Cutaneous; Dermatologic Agents; Dicarboxylic Acids; Humans

1996
Advances and perspectives in acne therapy.
    European journal of medical research, 1997, Aug-28, Volume: 2, Issue:8

    Topics: Acne Vulgaris; Administration, Topical; Androgen Antagonists; Anti-Infective Agents, Local; Benzoyl

1997
Azelaic acid 20% cream (AZELEX) and the medical management of acne vulgaris.
    Dermatology nursing, 1997, Volume: 9, Issue:5

    Topics: Acne Vulgaris; Clinical Trials as Topic; Dermatologic Agents; Dicarboxylic Acids; Humans; Ointments

1997
Acne vulgaris: a treatment update.
    Hospital practice (1995), 1998, Feb-15, Volume: 33, Issue:2

    Topics: Acne Vulgaris; Adapalene; Administration, Cutaneous; Administration, Oral; Anti-Bacterial Agents; An

1998
Topical therapy in acne.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 1998, Volume: 11 Suppl 1

    Topics: Acne Vulgaris; Administration, Cutaneous; Androgen Antagonists; Anti-Bacterial Agents; Bacteria; Ben

1998
Topical therapy for acne.
    American family physician, 2000, Jan-15, Volume: 61, Issue:2

    Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Anti-Bacterial Agents; Anti-Infective Age

2000
Combination azelaic acid therapy for acne vulgaris.
    Journal of the American Academy of Dermatology, 2000, Volume: 43, Issue:2 Pt 3

    Topics: Acne Vulgaris; Administration, Topical; Clinical Trials as Topic; Dermatologic Agents; Dicarboxylic

2000
Azelaic acid. A review of its pharmacological properties and therapeutic efficacy in acne and hyperpigmentary skin disorders.
    Drugs, 1991, Volume: 41, Issue:5

    Topics: Acne Vulgaris; Dermatologic Agents; Dicarboxylic Acids; Humans; Pigmentation Disorders

1991
[Azelaic acid in the treatment of acne].
    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 1989, Volume: 124, Issue:4

    Topics: Acne Vulgaris; Adolescent; Animals; Clinical Trials as Topic; Dermatologic Agents; Dicarboxylic Acid

1989
Topical therapy of acne.
    The Australasian journal of dermatology, 1986, Volume: 27, Issue:3

    Topics: Acne Vulgaris; Administration, Topical; Benzoyl Peroxide; Clindamycin; Dicarboxylic Acids; Erythromy

1986
Azelaic acid.
    Journal of the American Academy of Dermatology, 1987, Volume: 17, Issue:6

    Topics: Acne Vulgaris; Antineoplastic Agents; Dicarboxylic Acids; Humans; Skin Diseases; Skin Neoplasms

1987

Trials

24 trials available for azelaic acid and Acne

ArticleYear
The usefulness of a dermocosmetic containing Myrtus communis extract and azelaic acid for maintenance phase of adult female acne: Results from a randomized exploratory investigator-blinded comparative study.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2023, Volume: 37 Suppl 2

    Topics: Acne Vulgaris; Adult; Dermatologic Agents; Female; Humans; Immunoglobulin A; Myrtus; Severity of Ill

2023
A comparison of the effectiveness of azelaic and pyruvic acid peels in the treatment of female adult acne: a randomized controlled trial.
    Scientific reports, 2020, 07-28, Volume: 10, Issue:1

    Topics: Acne Vulgaris; Adult; Analysis of Variance; Dicarboxylic Acids; Female; Humans; Porosity; Pyruvic Ac

2020
The Efficacy and Safety of Azelaic Acid 15% Foam in the Treatment of Truncal Acne Vulgaris.
    Journal of drugs in dermatology : JDD, 2017, Jun-01, Volume: 16, Issue:6

    Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Child; Dermatologic Agents; Dicarboxylic

2017
A randomized investigator-blind parallel-group study to assess efficacy and safety of azelaic acid 15% gel vs. adapalene 0.1% gel in the treatment and maintenance treatment of female adult acne.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2015, Volume: 29, Issue:4

    Topics: Acne Vulgaris; Adapalene; Adult; Dermatologic Agents; Dicarboxylic Acids; Female; Gels; Humans; Main

2015
A randomized comparative trial of a combined oral contraceptive and azelaic acid to assess their effect on sleep quality in adult female acne patients.
    Archives of dermatological research, 2015, Volume: 307, Issue:10

    Topics: Acne Vulgaris; Adrenocorticotropic Hormone; Adult; Central Nervous System; Contraceptives, Oral, Com

2015
A multicentre, randomized, single-blind, parallel-group study comparing the efficacy and tolerability of benzoyl peroxide 3%/clindamycin 1% with azelaic acid 20% in the topical treatment of mild-to-moderate acne vulgaris.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2016, Volume: 30, Issue:6

    Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Benzoyl Peroxide; Child; Clindamycin; Dic

2016
Azelaic acid 20 % cream: effects on quality of life and disease severity in adult female acne patients.
    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2016, Volume: 14, Issue:12

    Topics: Acne Vulgaris; Administration, Cutaneous; Adolescent; Adult; Age Distribution; Austria; Dermatologic

2016
A study of the efficacy of cleansers for acne vulgaris.
    The Journal of dermatological treatment, 2010, Volume: 21, Issue:3

    Topics: Acne Vulgaris; Administration, Cutaneous; Adult; Detergents; Dicarboxylic Acids; Dose-Response Relat

2010
Combination of azelaic acid 5% and erythromycin 2% in the treatment of acne vulgaris.
    The Journal of dermatological treatment, 2010, Volume: 21, Issue:3

    Topics: Acne Vulgaris; Administration, Cutaneous; Adolescent; Adult; Analysis of Variance; Anti-Bacterial Ag

2010
Combination of azelaic acid 5% and clindamycin 2% for the treatment of acne vulgaris.
    Cutaneous and ocular toxicology, 2011, Volume: 30, Issue:4

    Topics: Acne Vulgaris; Administration, Topical; Anti-Bacterial Agents; Clindamycin; Dermatologic Agents; Dic

2011
Efficacy and safety of azelaic acid (AzA) gel 15% in the treatment of post-inflammatory hyperpigmentation and acne: a 16-week, baseline-controlled study.
    Journal of drugs in dermatology : JDD, 2011, Volume: 10, Issue:6

    Topics: Acne Vulgaris; Administration, Cutaneous; Black People; Dermatologic Agents; Dicarboxylic Acids; Fem

2011
Evaluation of self-treatment of mild-to-moderate facial acne with a blue light treatment system.
    Journal of drugs in dermatology : JDD, 2011, Volume: 10, Issue:6

    Topics: Acne Vulgaris; Adult; Combined Modality Therapy; Dermatologic Agents; Dicarboxylic Acids; Drug Combi

2011
Inflammatory acne management with a novel prescription dietary supplement.
    Journal of drugs in dermatology : JDD, 2012, Volume: 11, Issue:12

    Topics: Acne Vulgaris; Adolescent; Adult; Anti-Bacterial Agents; Child; Copper; Dicarboxylic Acids; Dietary

2012
[Azelaic acid 15% gel in the treatment of acne vulgaris. Combined results of two double-blind clinical comparative studies].
    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2004, Volume: 2, Issue:10

    Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Anti-Bacterial Agents; Benzoyl Peroxide;

2004
Relationship between sebostatic activity, tolerability and efficacy of three topical drugs to treat mild to moderate acne.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2007, Volume: 21, Issue:3

    Topics: Acne Vulgaris; Adapalene; Administration, Topical; Adolescent; Analysis of Variance; Benzoyl Peroxid

2007
Effects of azelaic acid on sebaceous gland, sebum excretion rate and keratinization pattern in human skin. An in vivo and in vitro study.
    Acta dermato-venereologica. Supplementum, 1989, Volume: 143

    Topics: Acne Vulgaris; Cell Differentiation; Cell Division; Cells, Cultured; Clinical Trials as Topic; Derma

1989
Clinical and laboratory studies on treatment with 20% azelaic acid cream for acne.
    Acta dermato-venereologica. Supplementum, 1989, Volume: 143

    Topics: Acne Vulgaris; Administration, Topical; Anti-Bacterial Agents; Clinical Trials as Topic; Dicarboxyli

1989
Clinical studies of 20% azelaic acid cream in the treatment of acne vulgaris. Comparison with vehicle and topical tretinoin.
    Acta dermato-venereologica. Supplementum, 1989, Volume: 143

    Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Child; Clinical Trials as Topic; Dicarbox

1989
Long-term treatment of acne with 20% azelaic acid cream.
    Acta dermato-venereologica. Supplementum, 1989, Volume: 143

    Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Benzoyl Peroxide; Dicarboxylic Acids; Fem

1989
Azelaic acid for the treatment of acne. A clinical comparison with oral tetracycline.
    Acta dermato-venereologica. Supplementum, 1989, Volume: 143

    Topics: Acne Vulgaris; Administration, Topical; Clinical Trials as Topic; Dicarboxylic Acids; Drug Tolerance

1989
[Azelaic acid in the treatment of acne].
    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 1989, Volume: 124, Issue:4

    Topics: Acne Vulgaris; Adolescent; Animals; Clinical Trials as Topic; Dermatologic Agents; Dicarboxylic Acid

1989
[National and international experiences with azelaic acid cream in the treatment of papulo-pustular acne].
    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 1989, Volume: 124, Issue:10

    Topics: Acne Vulgaris; Administration, Oral; Adolescent; Benzoyl Peroxide; Clinical Trials as Topic; Dermato

1989
[National and international clinical experiences with azelaic acid cream in the treatment of comedo acne].
    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 1989, Volume: 124, Issue:10

    Topics: Acne Vulgaris; Clinical Trials as Topic; Dermatologic Agents; Dicarboxylic Acids; Double-Blind Metho

1989
Topical azelaic acid and the treatment of acne: a clinical and laboratory comparison with oral tetracycline.
    The British journal of dermatology, 1986, Volume: 114, Issue:4

    Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Clinical Trials as Topic; Dicarboxylic Ac

1986

Other Studies

40 other studies available for azelaic acid and Acne

ArticleYear
Long-term effect of azelaic acid peel on sebum production in acne.
    Dermatologic therapy, 2022, Volume: 35, Issue:1

    Topics: Acne Vulgaris; Adult; Chemexfoliation; Dicarboxylic Acids; Female; Humans; Male; Sebum; Young Adult

2022
Hydrogel composite containing azelaic acid and tea tree essential oil as a therapeutic strategy for Propionibacterium and testosterone-induced acne.
    Drug delivery and translational research, 2022, Volume: 12, Issue:10

    Topics: Acne Vulgaris; Animals; Dicarboxylic Acids; Hydrogels; Propionibacterium; Rats; Rats, Wistar; Tea; T

2022
Azelaic acid and
    Therapeutic delivery, 2022, Volume: 13, Issue:1

    Topics: Acne Vulgaris; Animals; Anti-Bacterial Agents; Dicarboxylic Acids; Excipients; Hydrogels; Melaleuca;

2022
Azelaic acid loaded chitosan and HPMC based hydrogels for treatment of acne: formulation, characterization,
    Pharmaceutical development and technology, 2022, Volume: 27, Issue:3

    Topics: Acne Vulgaris; Chitosan; Dicarboxylic Acids; Humans; Hydrogels

2022
Probiotic supplement combined with topical therapy in the treatment of mild to moderate acne: results from an Italian single centre interventional study.
    Italian journal of dermatology and venereology, 2022, Volume: 157, Issue:6

    Topics: Acne Vulgaris; Biotin; Dermatologic Agents; Humans; Hydroxy Acids; Probiotics

2022
The Formulation and Evaluation of Deep Eutectic Vehicles for the Topical Delivery of Azelaic Acid for Acne Treatment.
    Molecules (Basel, Switzerland), 2023, Oct-04, Volume: 28, Issue:19

    Topics: Acne Vulgaris; Animals; Choline; Dermatologic Agents; Dicarboxylic Acids; Pharmaceutical Preparation

2023
Efficacy of 30% azelaic acid peel in the nonpharmacological treatment of facial acne.
    The Journal of dermatological treatment, 2021, Volume: 32, Issue:3

    Topics: Acne Vulgaris; Adolescent; Adult; Dicarboxylic Acids; Drug Administration Schedule; Face; Female; Hu

2021
Acid-base combination principles for preparation of anti-acne dissolving microneedles loaded with azelaic acid and matrine.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2021, Oct-01, Volume: 165

    Topics: Acne Vulgaris; Administration, Cutaneous; Alkaloids; Animals; Dicarboxylic Acids; Matrines; Quinoliz

2021
The Efficacy and Safety of Azelaic Acid 15% Foam in the Treatment of Facial Acne Vulgaris.
    Journal of drugs in dermatology : JDD, 2018, Jun-01, Volume: 17, Issue:6

    Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Dermatitis; Dicarboxylic Acids; Drug Comp

2018
[Acne therapy in pregnancy].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 2013, Volume: 64, Issue:4

    Topics: Acne Vulgaris; Administration, Oral; Administration, Topical; Adrenal Cortex Hormones; Benzoyl Perox

2013
Design of polymeric nanoparticles and its applications as drug delivery systems for acne treatment.
    Drug development and industrial pharmacy, 2014, Volume: 40, Issue:3

    Topics: Acne Vulgaris; Cell Survival; Chemistry, Pharmaceutical; Delayed-Action Preparations; Dicarboxylic A

2014
Development and evaluation of a novel topical treatment for acne with azelaic acid-loaded nanoparticles.
    Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada, 2013, Volume: 19, Issue:5

    Topics: Acne Vulgaris; Administration, Topical; Anti-Bacterial Agents; Delayed-Action Preparations; Dicarbox

2013
Are therapeutic effects of antiacne agents mediated by activation of FoxO1 and inhibition of mTORC1?
    Experimental dermatology, 2013, Volume: 22, Issue:7

    Topics: Acne Vulgaris; AMP-Activated Protein Kinases; Benzoyl Peroxide; Dermatologic Agents; Dicarboxylic Ac

2013
Azelaic acid in the treatment of acne in adult females: case reports.
    Skin pharmacology and physiology, 2014, Volume: 27 Suppl 1

    Topics: Acne Vulgaris; Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents; Dermatologic Agents; Dicarbox

2014
Acne vulgaris in the context of complex medical co-morbities: the management of severe acne vulgaris in a female with retinitis pigmentosa - utilizing pulse dye laser in conjunction with medical therapy.
    Dermatology online journal, 2014, Mar-17, Volume: 20, Issue:3

    Topics: Acne Vulgaris; Administration, Cutaneous; Adult; Androstenes; Anti-Infective Agents, Local; Combined

2014
A prodrug approach to enhance azelaic acid percutaneous availability.
    Pharmaceutical development and technology, 2017, Volume: 22, Issue:4

    Topics: Acne Vulgaris; Administration, Cutaneous; Dermatologic Agents; Dicarboxylic Acids; Gram-Positive Bac

2017
Infantile acne.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2016, Dec-06, Volume: 188, Issue:17-18

    Topics: Acne Vulgaris; Age of Onset; Anti-Bacterial Agents; Benzoyl Peroxide; Dermatologic Agents; Dicarboxy

2016
Azelaic acid modulates the inflammatory response in normal human keratinocytes through PPARgamma activation.
    Experimental dermatology, 2010, Volume: 19, Issue:9

    Topics: Acne Vulgaris; Cells, Cultured; Cytokines; Dermatologic Agents; Dicarboxylic Acids; Drug Evaluation,

2010
The efficacy of topical drugs in treatment of noninflammatory acne vulgaris.
    Georgian medical news, 2010, Issue:186

    Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Dermatologic Agents; Dicarboxylic Acids;

2010
Acne treatments: consider these options--and issues.
    The Journal of family practice, 2007, Volume: 56, Issue:5

    Topics: Acne Vulgaris; Anti-Bacterial Agents; Dermatologic Agents; Dicarboxylic Acids; Humans

2007
Beneficial effect of 15% azelaic acid cream on acne vulgaris.
    The British journal of dermatology, 1983, Volume: 109, Issue:1

    Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Dicarboxylic Acids; Female; Humans; Male;

1983
The effect of azelaic acid on acne.
    The British journal of dermatology, 1983, Volume: 109, Issue:6

    Topics: Acne Vulgaris; Adolescent; Adult; Dicarboxylic Acids; Female; Humans; Male; Sebum; Secretory Rate

1983
Follicular concentrations of azelaic acid after a single topical application.
    The British journal of dermatology, 1993, Volume: 129, Issue:4

    Topics: Acne Vulgaris; Administration, Topical; Adult; Back; Bacterial Infections; Chromatography, High Pres

1993
Azelaic acid-a new topical drug for acne.
    The Medical letter on drugs and therapeutics, 1996, Jun-07, Volume: 38, Issue:976

    Topics: Acne Vulgaris; Administration, Topical; Clinical Trials as Topic; Dermatologic Agents; Dicarboxylic

1996
New approaches in dermatology: a clinical profile of azelaic acid.
    Cutis, 1996, Volume: 57, Issue:1 Suppl

    Topics: Acne Vulgaris; Dermatologic Agents; Dicarboxylic Acids; Humans; Hyperpigmentation

1996
An ultrastructural study of the retention hyperkeratosis of experimentally induced comedones in rabbits: the effects of three comedolytics.
    The Journal of dermatology, 1996, Volume: 23, Issue:3

    Topics: Acne Vulgaris; Animals; Benzoyl Peroxide; Dermatologic Agents; Dicarboxylic Acids; Disease Models, A

1996
Topical drug treatment in acne.
    Dermatology (Basel, Switzerland), 1998, Volume: 196, Issue:1

    Topics: Acne Vulgaris; Administration, Topical; Anti-Bacterial Agents; Benzoyl Peroxide; Dermatologic Agents

1998
The science and art of treating acne in adolescence.
    The Western journal of medicine, 2000, Volume: 172, Issue:3

    Topics: Acne Vulgaris; Adolescent; Anti-Bacterial Agents; Benzoyl Peroxide; Dermatologic Agents; Dicarboxyli

2000
["Cleansing, topical treatment, oral administration". Controlling acne].
    MMW Fortschritte der Medizin, 2001, Jul-26, Volume: 143, Issue:30

    Topics: Acne Vulgaris; Administration, Oral; Administration, Topical; Adolescent; Adult; Combined Modality T

2001
Azelaic acid (20%) cream in the treatment of acne vulgaris.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2002, Volume: 16, Issue:2

    Topics: Acne Vulgaris; Administration, Topical; Adolescent; Adult; Dermatologic Agents; Dicarboxylic Acids;

2002
[Azelaic Acid--a new application in acne therapy. Expert's exchange. Berlin, 18-20 January 1991].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1991, Volume: 42, Issue:3 Suppl

    Topics: Acne Vulgaris; Dermatologic Agents; Dicarboxylic Acids; Humans

1991
[Azelaic acid for keratinization disorders?].
    Medizinische Monatsschrift fur Pharmazeuten, 1991, Volume: 14, Issue:12

    Topics: Acne Vulgaris; Dermatologic Agents; Dicarboxylic Acids; Humans; Keratinocytes; Keratosis

1991
[Evaluation of the anti-comedo effect of azelaic acid using the technique of horny layer biopsy and scanning electron microscopy].
    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 1990, Volume: 125, Issue:7-8

    Topics: Acne Vulgaris; Adult; Biopsy; Dermatologic Agents; Dicarboxylic Acids; Epidermis; Female; Humans; Ma

1990
Pharmacology and toxicology of azelaic acid.
    Acta dermato-venereologica. Supplementum, 1989, Volume: 143

    Topics: Acne Vulgaris; Animals; Anti-Infective Agents; Dicarboxylic Acids; Disease Models, Animal; Lipids; S

1989
[Azelaic acid: an innovation in the treatment of acne. Introduction and history].
    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 1989, Volume: 124, Issue:10

    Topics: Acne Vulgaris; Administration, Oral; Adolescent; Dermatologic Agents; Dicarboxylic Acids; Drug Evalu

1989
[Mechanism of azelaic acid action in acne].
    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 1989, Volume: 124, Issue:10

    Topics: Acne Vulgaris; Cholestenone 5 alpha-Reductase; Dermatologic Agents; Dicarboxylic Acids; Humans; Kera

1989
[Validity of azelaic acid in the therapy of acne. Long-term clinical results].
    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 1989, Volume: 124, Issue:10

    Topics: Acne Vulgaris; Adolescent; Adult; Dermatologic Agents; Dicarboxylic Acids; Drug Evaluation; Female;

1989
[Topical therapeutic action of azelaic acid in polymorphous acne].
    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 1989, Volume: 124, Issue:10

    Topics: Acne Vulgaris; Adolescent; Adult; Dermatologic Agents; Dicarboxylic Acids; Drug Evaluation; Female;

1989
Azelaic acid and sebum excretion rate.
    The British journal of dermatology, 1985, Volume: 113, Issue:6

    Topics: Acne Vulgaris; Dicarboxylic Acids; Humans; Sebum; Secretory Rate

1985
The in vitro antimicrobial effect of azelaic acid.
    The British journal of dermatology, 1986, Volume: 115, Issue:5

    Topics: Acne Vulgaris; Bacteria; Culture Media; Dicarboxylic Acids; Humans; Malassezia; Microbial Sensitivit

1986