azd-7762 has been researched along with Multiple-Myeloma* in 1 studies
1 other study(ies) available for azd-7762 and Multiple-Myeloma
| Article | Year |
|---|---|
Design, synthesis and biological evaluation of thienopyridinones as Chk1 inhibitors.
A series of thienopyridinone derivatives was designed and synthesized as inhibitors of checkpoint kinase 1 (Chk1). Most of them exhibited moderate to good Chk1 inhibitory activities. Among them, compounds 8q, 8t, and 8w with excellent Chk1 inhibitory activities (IC50 values of 4.05, 6.23, and 2.33nM, respectively) displayed strong synergistic effects with melphalan, a DNA-damaging agent in the cell-based assay. Further kinase profiling indicated that compound 8t was highly selective against CDK2/cyclinA, Aurora A, and PKC. Topics: Cell Line, Tumor; Cell Proliferation; Checkpoint Kinase 1; Dose-Response Relationship, Drug; Drug Design; Humans; Molecular Docking Simulation; Molecular Structure; Multiple Myeloma; Protein Kinase Inhibitors; Protein Kinases; Pyridones; Structure-Activity Relationship | 2014 |