azauridine has been researched along with Experimental Neoplasms in 7 studies
Azauridine: A triazine nucleoside used as an antineoplastic antimetabolite. It interferes with pyrimidine biosynthesis thereby preventing formation of cellular nucleic acids. As the triacetate, it is also effective as an antipsoriatic.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The resistance of these hepatoma cells to low concentrations of D-galactosamine (less than 2 mM) was due to their active de novo pyrimidine synthesis which compensated the trapping of uridylate in the form of uridine diphosphate-amino sugars derived from D-galactosamine." | 1.26 | Uridine triphosphate deficiency, growth inhibition, and death in ascites hepatoma cells induced by a combination of pyrimidine biosynthesis inhibition with uridylate trapping. ( Keppler, DO, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| BRUEMMER, NC | 1 |
| HOLLAND, JF | 1 |
| SHEEHE, PR | 1 |
| VESELY, J | 2 |
| Cihák, A | 2 |
| Rada, B | 1 |
| Keppler, DO | 1 |
| Janeway, CM | 1 |
| Cha, S | 1 |
| Kline, I | 1 |
1 review available for azauridine and Experimental Neoplasms
| Article | Year |
|---|---|
Resistance of mammalian tumour cells toward pyrimidine analogues. A review.
Topics: Animals; Antimetabolites; Azacitidine; Azauridine; Bromouracil; Carcinoma, Ehrlich Tumor; Cell Line; | 1973 |
6 other studies available for azauridine and Experimental Neoplasms
| Article | Year |
|---|---|
Drug effects on a target metabolic pathway and on mouse tumor growth: azauridine and decarboxylation of orotic acid-7-C-14.
Topics: Animals; Azauridine; Decarboxylation; Metabolic Networks and Pathways; Mice; Neoplasms; Neoplasms, E | 1962 |
THE EFFECT OF 6-AZAURIDINE AND 6-AZACYTIDINE ON THE INTRACELLULAR SYNTHESIS OF RNA IN FOWL LEUKEMIC AND NORMAL MYELOBLASTS IN VITRO.
Topics: Animals; Antimetabolites; Autoradiography; Azacitidine; Azauridine; Bone Marrow Examination; Cytopla | 1964 |
Uridine kinase: properties, biological significance and chemotherapeutic aspects (a review).
Topics: Animals; Azacitidine; Azauridine; Molecular Weight; Neoplasms, Experimental; Phosphotransferases; Py | 1976 |
Uridine triphosphate deficiency, growth inhibition, and death in ascites hepatoma cells induced by a combination of pyrimidine biosynthesis inhibition with uridylate trapping.
Topics: Animals; Azauridine; Carcinoma, Hepatocellular; Cell Division; Cells, Cultured; Female; Galactosamin | 1977 |
Effects of 6-azauridine on nucleotides, orotic acid, and orotidine in L5178Y mouse lymphoma cells in vitro.
Topics: Azauridine; Cells, Cultured; Lymphoma; Neoplasms, Experimental; Nucleotides; Orotate Phosphoribosylt | 1977 |
Potentially useful combinations of chemotherapy detected in mouse tumor systems.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Azauridine; Bleomycin; Camptothecin; Cyclic P-Oxides | 1974 |