azauridine has been researched along with Carcinoma, Hepatocellular in 4 studies
Azauridine: A triazine nucleoside used as an antineoplastic antimetabolite. It interferes with pyrimidine biosynthesis thereby preventing formation of cellular nucleic acids. As the triacetate, it is also effective as an antipsoriatic.
Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sixteen unselected patients with non-resectable hepatocellular carcinoma were treated in a phase I study with 261 cycles of D-galactosamine and 6-azauridine prior to 5-fluorouridine." | 7.67 | First clinical experiences with a selective chemotherapy of hepatocellular carcinoma with 5-fluorouridine in combination with other antipyrimidines. ( Anukarahanonta, T; Gerok, W; Holstege, A; Keppler, D; Pausch, J, 1985) |
| "Sixteen unselected patients with non-resectable hepatocellular carcinoma were treated in a phase I study with 261 cycles of D-galactosamine and 6-azauridine prior to 5-fluorouridine." | 3.67 | First clinical experiences with a selective chemotherapy of hepatocellular carcinoma with 5-fluorouridine in combination with other antipyrimidines. ( Anukarahanonta, T; Gerok, W; Holstege, A; Keppler, D; Pausch, J, 1985) |
| "The resistance of these hepatoma cells to low concentrations of D-galactosamine (less than 2 mM) was due to their active de novo pyrimidine synthesis which compensated the trapping of uridylate in the form of uridine diphosphate-amino sugars derived from D-galactosamine." | 1.26 | Uridine triphosphate deficiency, growth inhibition, and death in ascites hepatoma cells induced by a combination of pyrimidine biosynthesis inhibition with uridylate trapping. ( Keppler, DO, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Clementi, M | 1 |
| Bagnarelli, P | 1 |
| Pauri, P | 1 |
| Calegari, L | 1 |
| Keppler, DO | 2 |
| Pausch, JG | 1 |
| Gerok, W | 2 |
| Pausch, J | 1 |
| Holstege, A | 1 |
| Anukarahanonta, T | 1 |
| Keppler, D | 1 |
4 other studies available for azauridine and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Modulation of production of hepatitis B surface antigen by a human hepatoma cell line.
Topics: Anti-Bacterial Agents; Azauridine; Carcinoma, Hepatocellular; Cell Division; Cell Line; Deoxyadenosi | 1984 |
Uridine triphosphate deficiency, growth inhibition, and death in ascites hepatoma cells induced by a combination of pyrimidine biosynthesis inhibition with uridylate trapping.
Topics: Animals; Azauridine; Carcinoma, Hepatocellular; Cell Division; Cells, Cultured; Female; Galactosamin | 1977 |
Increased de novo pyrimidine nucleotide synthesis in liver induced by ammonium ions in amounts surpassing the urea cycle capacity.
Topics: Animals; Azauridine; Carbamoyl-Phosphate Synthase (Ammonia); Carbamoyl-Phosphate Synthase (Glutamine | 1977 |
First clinical experiences with a selective chemotherapy of hepatocellular carcinoma with 5-fluorouridine in combination with other antipyrimidines.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Azauridine; Carcinoma, Hepatocellular; | 1985 |