azauridine has been researched along with Cancer of Liver in 4 studies
Azauridine: A triazine nucleoside used as an antineoplastic antimetabolite. It interferes with pyrimidine biosynthesis thereby preventing formation of cellular nucleic acids. As the triacetate, it is also effective as an antipsoriatic.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sixteen unselected patients with non-resectable hepatocellular carcinoma were treated in a phase I study with 261 cycles of D-galactosamine and 6-azauridine prior to 5-fluorouridine." | 7.67 | First clinical experiences with a selective chemotherapy of hepatocellular carcinoma with 5-fluorouridine in combination with other antipyrimidines. ( Anukarahanonta, T; Gerok, W; Holstege, A; Keppler, D; Pausch, J, 1985) |
| "Sixteen unselected patients with non-resectable hepatocellular carcinoma were treated in a phase I study with 261 cycles of D-galactosamine and 6-azauridine prior to 5-fluorouridine." | 3.67 | First clinical experiences with a selective chemotherapy of hepatocellular carcinoma with 5-fluorouridine in combination with other antipyrimidines. ( Anukarahanonta, T; Gerok, W; Holstege, A; Keppler, D; Pausch, J, 1985) |
| "The resistance of these hepatoma cells to low concentrations of D-galactosamine (less than 2 mM) was due to their active de novo pyrimidine synthesis which compensated the trapping of uridylate in the form of uridine diphosphate-amino sugars derived from D-galactosamine." | 1.26 | Uridine triphosphate deficiency, growth inhibition, and death in ascites hepatoma cells induced by a combination of pyrimidine biosynthesis inhibition with uridylate trapping. ( Keppler, DO, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Clementi, M | 1 |
| Bagnarelli, P | 1 |
| Pauri, P | 1 |
| Calegari, L | 1 |
| Keppler, DO | 2 |
| Pausch, JG | 1 |
| Gerok, W | 2 |
| Pausch, J | 1 |
| Holstege, A | 1 |
| Anukarahanonta, T | 1 |
| Keppler, D | 1 |
4 other studies available for azauridine and Cancer of Liver
| Article | Year |
|---|---|
Modulation of production of hepatitis B surface antigen by a human hepatoma cell line.
Topics: Anti-Bacterial Agents; Azauridine; Carcinoma, Hepatocellular; Cell Division; Cell Line; Deoxyadenosi | 1984 |
Uridine triphosphate deficiency, growth inhibition, and death in ascites hepatoma cells induced by a combination of pyrimidine biosynthesis inhibition with uridylate trapping.
Topics: Animals; Azauridine; Carcinoma, Hepatocellular; Cell Division; Cells, Cultured; Female; Galactosamin | 1977 |
Increased de novo pyrimidine nucleotide synthesis in liver induced by ammonium ions in amounts surpassing the urea cycle capacity.
Topics: Animals; Azauridine; Carbamoyl-Phosphate Synthase (Ammonia); Carbamoyl-Phosphate Synthase (Glutamine | 1977 |
First clinical experiences with a selective chemotherapy of hepatocellular carcinoma with 5-fluorouridine in combination with other antipyrimidines.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Azauridine; Carcinoma, Hepatocellular; | 1985 |