Page last updated: 2024-11-07

azauridine and Abnormalities, Drug-Induced

azauridine has been researched along with Abnormalities, Drug-Induced in 9 studies

Azauridine: A triazine nucleoside used as an antineoplastic antimetabolite. It interferes with pyrimidine biosynthesis thereby preventing formation of cellular nucleic acids. As the triacetate, it is also effective as an antipsoriatic.

Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.

Research Excerpts

ExcerptRelevanceReference
"The reproductive performance of 36 women who had been successfully treated for gestational trophoblastic tumors with multiple courses of cytotoxic agents including methotrexate, 6-mercaptopurine, actinomycin D, and 6-azauridine, between 1962 and 1972, has been studied in comparison with 36 patients who had spontaneously aborted a hydatidiform mole but received no treatment and a control group consisting of 36 women attending an antenatal clinic."3.65Reproductive performance of women successfully treated for gestational trophoblastic tumors. ( Bagshawe, KD; Walden, PA, 1976)
" Considering the sensitivity peaks of the morphogenetic processes which were observed, the dose-response relationships, the transformation of the teratogenic to a lethal effect and critical period extension with increasing doses, it was found that the effects of ia and im administered 6-azauridine did not differ."1.26Embryotoxicity of transplacentally and intraamniotically administered 6-azauridine in mice. ( Dostál, M; Jelínek, R, 1979)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19909 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Walden, PA1
Bagshawe, KD1
Dostál, M1
Jelínek, R3
Bílá, V1
Kren, V1
Rychter, Z2
Peterka, M1
Shepard, TH1
Lemez, L1
Jedlicka, V2
Grafnetterová, J2
Povýsilová, V1
van Wagenen, G1
DeConti, RC1
Handschumacher, RE1
Wade, ME1

Other Studies

9 other studies available for azauridine and Abnormalities, Drug-Induced

ArticleYear
Reproductive performance of women successfully treated for gestational trophoblastic tumors.
    American journal of obstetrics and gynecology, 1976, Aug-15, Volume: 125, Issue:8

    Topics: Abnormalities, Drug-Induced; Antineoplastic Agents; Azauridine; Child; Child, Preschool; Dactinomyci

1976
Embryotoxicity of transplacentally and intraamniotically administered 6-azauridine in mice.
    Teratology, 1979, Volume: 19, Issue:2

    Topics: Abnormalities, Drug-Induced; Amnion; Animals; Azauridine; Cleft Lip; Cleft Palate; Embryo, Mammalian

1979
Mutant gene--teratogen interaction studied on different genetic backgrounds.
    Folia biologica, 1978, Volume: 24, Issue:6

    Topics: Abnormalities, Drug-Induced; Alleles; Animals; Azauridine; Crosses, Genetic; Female; Genotype; Heter

1978
[Early detection of teratogenous effects on chick embryo].
    Ceskoslovenska pediatrie, 1972, Volume: 27, Issue:8

    Topics: Abnormalities, Drug-Induced; Animals; Azauridine; Chick Embryo; Dactinomycin; Morphogenesis; Thiazin

1972
Teratogenicity from drugs--an increasing problem.
    Disease-a-month : DM, 1974

    Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Aminopterin; Amniocentesis; Animals; Anti-Bact

1974
Incidence and localization of heterotopic thymic tissue in the brachiogenic organs of the one-day-old chick.
    Folia morphologica, 1973, Volume: 21, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Azauridine; Branchial Region; Chick Embryo; Thymus Gland

1973
Morphological effects of 6-azauridine on the development of the chick.
    Acta Universitatis Carolinae. Medica, 1973, Volume: 19, Issue:7-8

    Topics: Abnormalities, Drug-Induced; Animals; Azauridine; Chick Embryo

1973
Abortifacient and teratogenic effects of triacetyl-6-azauridine in the monkey.
    American journal of obstetrics and gynecology, 1970, Sep-15, Volume: 108, Issue:2

    Topics: Abnormalities, Drug-Induced; Abortifacient Agents; Animals; Antimetabolites; Azauridine; Contracepti

1970
[Method for evaluation of the effect of teratogenic agents (6-azauridine) on late development stages].
    Ceskoslovenska fysiologie, 1971, Volume: 20, Issue:6

    Topics: Abnormalities, Drug-Induced; Animals; Antimetabolites; Azauridine; Chick Embryo; Embryonic and Fetal

1971