Page last updated: 2024-10-23

azathioprine and Viral Diseases

azathioprine has been researched along with Viral Diseases in 52 studies

Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.

Research Excerpts

ExcerptRelevanceReference
"The incidence of viral infections was 53."2.71Does mycophenolate mofetil increase the incidence of infections in renal transplant recipients? ( Agafonova, S; Budnikova, N; Pasov, S; Prokopenko, E; Scherbakova, E; Vatazin, A, 2005)
"In group 1, however, a higher number of viral infections and steroid-related side effects was noted."2.68Long-term outcome after switch from cyclosporine-based triple-drug immunosuppression to double therapy at three months. ( Aichberger, C; Eberl, T; Königsrainer, A; Margreiter, R; Ofner, D; Pernthaler, H; Riedmann, B, 1996)
"Azathioprine is a useful drug in severe JCA, with a sustained effect and acceptable side effects."2.68Azathioprine in patients with juvenile chronic arthritis: a longterm followup study. ( Aho, K; Isomäki, H; Kautiainen, H; Savolainen, HA; Verronen, P, 1997)
"Myocarditis is defined as inflammation of the myocardium accompanied by myocellular necrosis."2.49Corticosteroids for viral myocarditis. ( Chen, HS; Liu, JP; Wang, W; Wu, SN, 2013)
"Myocarditis is the inflammation of the myocardial tissue, primarily caused by viral infection."1.43[Effect of immune therapy in the prognosis of viral myocarditis in pediatric patients]. ( González-Espinosa, AM; López-Gallegos, D; Márquez-González, H; Yáñez-Gutiérrez, L; Zamudio-López, JO, 2016)
"Etiology and pathogenesis of Crohn's disease, the incidence of which seems to be increasing lately, are still unknown."1.26[Clinical features of inflammatory bowel disease (author's transl)]. ( Classen, M; Leuschner, U; Strohm, WD, 1982)
"Patterns of infection are recognized, and this should enable the physician to plan a meaningful course of action when infection occurs in the compromised host."1.25Infections in the immunosuppressed patient. ( O'Loughlin, JM, 1975)
"Azathioprine was best tolerated, but gave only medium results whereas procarbazine, as a very potent drug, had the highest rate of side effects (especially depression of bone marrow, infections, gastrointestinal manifestations etc."1.25[Side effects in immunosuppressive therapy]. ( Thumb, N, 1975)

Research

Studies (52)

TimeframeStudies, this research(%)All Research%
pre-199035 (67.31)18.7374
1990's9 (17.31)18.2507
2000's4 (7.69)29.6817
2010's4 (7.69)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chen, HS1
Wang, W1
Wu, SN1
Liu, JP1
Márquez-González, H1
López-Gallegos, D1
González-Espinosa, AM1
Zamudio-López, JO1
Yáñez-Gutiérrez, L1
Guillevin, L1
Pagnoux, C1
McKiernan, PJ1
Meggitt, SJ1
Anstey, AV1
Mohd Mustapa, MF1
Reynolds, NJ1
Wakelin, S1
Prokopenko, E1
Scherbakova, E1
Vatazin, A1
Pasov, S1
Budnikova, N1
Agafonova, S1
Leuschner, U1
Strohm, WD1
Classen, M1
Light, JA1
Biggers, JA1
Alijani, MR1
Smith, M1
Oddendino, K1
McDonald, WI1
Schellekens, H2
Smiers-de Vreede, E1
de Reus, A1
Dijkema, R1
Harris, KR1
Saeed, AA1
Digard, NJ1
Gosling, DC1
Leppington, LT1
Slapak, M1
Malagó, M1
Rogiers, X1
Wadström, J1
Burdelski, M1
Broelsch, CE1
Aichberger, C1
Eberl, T1
Riedmann, B1
Pernthaler, H1
Ofner, D1
Königsrainer, A1
Margreiter, R1
Bridges, ND1
Mallory, GB1
Huddleston, CB1
Canter, CE1
Spray, TL1
Lesnoni La Parola, I1
Masini, C1
Nanni, G1
Diociaiuti, A1
Panocchia, N1
Cerimele, D1
Savolainen, HA1
Kautiainen, H1
Isomäki, H1
Aho, K1
Verronen, P1
Vela, C1
Cristol, JP1
Chong, G1
Okamba, A1
Lorho, R1
Mion, C1
Mourad, G1
Tareeva, IE1
Shilov, EM1
Krasnova, TN1
Kozlovskaia, LV1
Shvetsov, MIu1
Ianushkevich, TN1
Samokishina, NA1
Bernabeu-Wittel, M1
Naranjo, M1
Cisneros, JM1
Cañas, E1
Gentil, MA1
Algarra, G1
Pereira, P1
González-Roncero, FJ1
de Alarcón, A1
Pachón, J1
McClure, PD1
Spencer, ES1
Andersen, HK1
Weimar, W1
Lameijer, LD1
Masurel, N1
Haas, RJ1
Pöschl, U1
Christ, M1
Schaub, J1
Belohradsky, BH1
O'Loughlin, JM1
Thumb, N1
Pettersson, S1
Hansson, G1
Blohmé, I1
Klauser, R1
Zlabinger, GJ1
Traindl, O1
Franz, M1
Watschinger, B1
Pohanka, E1
Kudlacek, S1
Kovarik, J1
d'Ivernois, C1
Dupon, M1
Dartigues, JF1
Potaux, L1
Aparicio, M1
Lacut, JY1
Thayer, C1
Bartlett, ST1
Ward, RE1
Wilkinson, AH1
Smith, JL1
Hunsicker, LG1
Tobacman, J1
Kapelanski, DP1
Johnson, M1
Wright, FH1
Behrendt, DM1
Corry, RJ1
Laufer, G1
Laczkovics, A1
Wollenek, G1
Buxbaum, P1
Graninger, W1
Holzinger, C1
Wolner, E1
Shmueli, D1
Shapira, Z1
Yussim, A1
Nakache, R1
Ram, Z1
Shaharabani, E1
Solomon, LR1
Martin, S1
Short, CD1
Lawler, W1
Gokal, R1
Johnson, RW1
Mallick, NP1
Yasumura, T1
Ohmori, Y1
Aikawa, I1
Fukuda, M1
Suzuki, S1
Nakai, I1
Matsui, S1
Oka, T1
Berardinelli, L1
Raiteri, M1
De Vecchi, A1
Vegeto, A1
Burgos-Calderon, R1
Pankey, GA1
Figueroa, JE1
Joseph, RR1
Tourtellotte, CD1
Barry, WE1
Smalley, RV1
Durant, JR1
Fournier, C1
Bach, MA1
Dardenne, M1
Bach, JF1
Allison, AC1
Thiry, L1
Prévost, JM1
Toussaint, C1
Vereerstraeten, P1
Coleman, DV1
Gardner, SD1
Field, AM1
Cendrowski, W1
Riekkinen, PJ1
Rinne, UK1
Wellman, MR1
Miller, DR1
Chebat, J1
Gluckman, JC1
Legrain, M1
Kuss, R1
Perkins, ES1
Thomas, F1
Lee, HM1
Wolf, JS1
Thomas, J1
Denman, AM1
Russell, AS1
Denman, EJ1
Stinson, EB1
Bieber, CP1
Griepp, RB1
Clark, DA1
Shumway, NE1
Remington, JS1
Manz, HJ1
Dinsdale, HB1
Morrin, PA1
Meere, C1
Grondin, CM1
Castonguay, Y1
Lepage, G1
Grondin, P1
Schuppli, R1
Sirtori, C1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Single-blind, Investigator-initiated, Randomized, Controlled Trial to Assess the Safety and Efficacy of Intravenous Corticosteroid Therapy to Treat Patients With Acute Myocarditis With Mildly Reduced Left Ventricular Ejection Fraction[NCT05974462]Phase 3174 participants (Anticipated)Interventional2024-01-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for azathioprine and Viral Diseases

ArticleYear
Corticosteroids for viral myocarditis.
    The Cochrane database of systematic reviews, 2013, Oct-18, Issue:10

    Topics: Acute Disease; Adrenal Cortex Hormones; Adult; Azathioprine; Child; Chronic Disease; Cyclosporine; H

2013
[Treatment of systemic vasculitides].
    La Revue du praticien, 2008, Mar-15, Volume: 58, Issue:5

    Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Antiviral Agents; Azathioprine; Ch

2008
Idiopathic thrombocytopenic purpura in children: diagnosis and management.
    Pediatrics, 1975, Volume: 55, Issue:1

    Topics: Age Factors; Autoantibodies; Autoimmune Diseases; Azathioprine; Blood Cell Count; Blood Coagulation

1975
Immunosuppressive therapy in neurological diseases.
    Annals of clinical research, 1974, Volume: 6, Issue:6

    Topics: Adrenocorticotropic Hormone; Azathioprine; Central Nervous System Diseases; Cyclophosphamide; Cytara

1974
Recent advances in the study of uveitis.
    The British journal of ophthalmology, 1974, Volume: 58, Issue:4

    Topics: Adult; Antibodies; Antigen-Antibody Reactions; Aqueous Humor; Azathioprine; Cell Migration Inhibitio

1974

Trials

7 trials available for azathioprine and Viral Diseases

ArticleYear
Does mycophenolate mofetil increase the incidence of infections in renal transplant recipients?
    Drugs under experimental and clinical research, 2005, Volume: 31, Issue:5-6

    Topics: Azathioprine; Bacterial Infections; Cyclosporine; Drug Therapy, Combination; Female; Humans; Immunos

2005
Long-term outcome after switch from cyclosporine-based triple-drug immunosuppression to double therapy at three months.
    Clinical transplantation, 1996, Volume: 10, Issue:2

    Topics: Adolescent; Adult; Aged; Azathioprine; Cadaver; Cyclosporine; Drug Combinations; Female; Follow-Up S

1996
Azathioprine in patients with juvenile chronic arthritis: a longterm followup study.
    The Journal of rheumatology, 1997, Volume: 24, Issue:12

    Topics: Adolescent; Amyloidosis; Antirheumatic Agents; Arthritis, Juvenile; Azathioprine; Child; Chronic Dis

1997
Antilymphocyte globulins versus OKT3 as prophylactic treatment in highly sensitized renal transplant recipients.
    Transplant international : official journal of the European Society for Organ Transplantation, 1994, Volume: 7 Suppl 1

    Topics: Adult; Aged; Antibodies; Antilymphocyte Serum; Azathioprine; Cyclosporine; Drug Therapy, Combination

1994
Infections in renal transplant recipients receiving mycophenolate versus azathioprine-based immunosuppression.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2002, Volume: 21, Issue:3

    Topics: Adult; Azathioprine; Bacterial Infections; Cohort Studies; Drug Therapy, Combination; Female; Humans

2002
Influence of immunosuppressive therapy on infectious complications in renal transplant recipients.
    Transplantation proceedings, 1992, Volume: 24, Issue:1

    Topics: Adult; Antilymphocyte Serum; Azathioprine; Bacteremia; Cyclosporine; Female; Graft Rejection; Humans

1992
Increased septic complications with three-drug sequential immunosuppression for cadaver renal transplants.
    American journal of surgery, 1990, Volume: 160, Issue:6

    Topics: Adult; Antilymphocyte Serum; Azathioprine; Bacterial Infections; Cadaver; Cyclosporins; Female; Graf

1990

Other Studies

40 other studies available for azathioprine and Viral Diseases

ArticleYear
[Effect of immune therapy in the prognosis of viral myocarditis in pediatric patients].
    Revista medica del Instituto Mexicano del Seguro Social, 2016, Volume: 54 Suppl 3

    Topics: Adolescent; Antiviral Agents; Azathioprine; Child; Child, Preschool; Drug Therapy, Combination; Fema

2016
Long-term care following paediatric liver transplantation.
    Archives of disease in childhood. Education and practice edition, 2011, Volume: 96, Issue:3

    Topics: Azathioprine; Calcineurin Inhibitors; Child; Continuity of Patient Care; Glucocorticoids; Graft Reje

2011
British Association of Dermatologists' guidelines for the safe and effective prescribing of azathioprine 2011.
    The British journal of dermatology, 2011, Volume: 165, Issue:4

    Topics: Abnormalities, Drug-Induced; Adult; Aged; Azathioprine; Bone Marrow Diseases; Chemical and Drug Indu

2011
[Clinical features of inflammatory bowel disease (author's transl)].
    Acta medica Austriaca, 1982, Volume: 9, Issue:1

    Topics: Azathioprine; Bacterial Infections; Crohn Disease; Diarrhea; Drug Combinations; Fluid Therapy; Gluco

1982
Serum beta-2-microglobulin: an adjunctive monitoring test in renal transplantation.
    Proceedings of the Clinical Dialysis and Transplant Forum, 1980, Volume: 10

    Topics: Antilymphocyte Serum; Azathioprine; beta 2-Microglobulin; Beta-Globulins; Creatinine; Graft Rejectio

1980
Multiple sclerosis: the present position.
    Acta neurologica Scandinavica, 1983, Volume: 68, Issue:2

    Topics: Adolescent; Age Factors; Azathioprine; Diseases in Twins; Emigration and Immigration; Environment; E

1983
Antiviral activity of interferon in rats and the effect of immune suppression.
    The Journal of general virology, 1984, Volume: 65 ( Pt 2)

    Topics: Animals; Azathioprine; Cell Line; Cyclophosphamide; Cyclosporins; Dose-Response Relationship, Drug;

1984
A comparison of serologically defined viral infection rates (cytomegalovirus, herpes simplex, and herpes virus varicellae) posttransplant in patients on azathioprine and cyclosporine.
    Transplantation proceedings, 1984, Volume: 16, Issue:5

    Topics: Azathioprine; Cyclosporins; Humans; Immunosuppression Therapy; Kidney Transplantation; Virus Disease

1984
Optimal clinical regimens for living related liver transplantation.
    Transplantation proceedings, 1994, Volume: 26, Issue:5

    Topics: Azathioprine; Bacterial Infections; Child; Child, Preschool; Cyclosporine; Drug Administration Sched

1994
Lung transplantation in infancy and early childhood.
    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 1996, Volume: 15, Issue:9

    Topics: Actuarial Analysis; Azathioprine; Cause of Death; Cyclosporine; Graft Rejection; Heart Defects, Cong

1996
Kaposi's sarcoma in renal-transplant recipients: experience at the Catholic University in Rome, 1988-1996.
    Dermatology (Basel, Switzerland), 1997, Volume: 194, Issue:3

    Topics: Adult; Anti-Inflammatory Agents; Azathioprine; Cyclosporine; Female; Follow-Up Studies; HIV Seronega

1997
[Lupus nephritis in the middle of the 20th century and in the beginning of 21st century].
    Terapevticheskii arkhiv, 2001, Volume: 73, Issue:6

    Topics: Adrenal Cortex Hormones; Adult; Anti-Inflammatory Agents; Azathioprine; Cyclophosphamide; Diagnosis,

2001
Viral infections in renal allograft recipients treated with long-term immunosuppression.
    British medical journal, 1979, Oct-06, Volume: 2, Issue:6194

    Topics: Adult; Azathioprine; Cytomegalovirus Infections; Female; Follow-Up Studies; Herpes Zoster; Humans; K

1979
[Virus infections in kidney transplant patients].
    Nederlands tijdschrift voor geneeskunde, 1977, Apr-30, Volume: 121, Issue:18

    Topics: Antibody Formation; Azathioprine; Herpesviridae; Humans; Immunity, Cellular; Immunosuppression Thera

1977
[Autoimmune hemolytic anaemia in childhood. Review and report of one case (author's transl)].
    Klinische Padiatrie, 1977, Volume: 189, Issue:3

    Topics: Anemia, Hemolytic, Autoimmune; Autoantibodies; Azathioprine; Chronic Disease; Cortisone; Cyclophosph

1977
Infections in the immunosuppressed patient.
    The Medical clinics of North America, 1975, Volume: 59, Issue:2

    Topics: Adrenal Cortex Hormones; Alkylating Agents; Antineoplastic Agents; Azathioprine; Bacteria; Bacterial

1975
[Side effects in immunosuppressive therapy].
    Acta medica Austriaca, 1975, Volume: 2, Issue:4

    Topics: Alopecia; Amenorrhea; Anemia; Azathioprine; Bacterial Infections; Chlorambucil; Female; Humans; Immu

1975
Condyloma acuminatum of the bladder.
    The Journal of urology, 1976, Volume: 115, Issue:5

    Topics: Adult; Azathioprine; Condylomata Acuminata; Electrosurgery; Female; Humans; Middle Aged; Prednisolon

1976
Decreased incidence of infection after renal transplantation with the use of cyclosporine.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1991, Volume: 10, Issue:11

    Topics: Adolescent; Adult; Antilymphocyte Serum; Azathioprine; Bacterial Infections; Child; Cyclosporine; Dr

1991
Increased frequency of posttransplant lymphomas in patients treated with cyclosporine, azathioprine, and prednisone.
    Transplantation, 1989, Volume: 47, Issue:2

    Topics: Adult; Aged; Azathioprine; B-Lymphocytes; Cyclosporins; Drug Therapy, Combination; Female; Graft Rej

1989
Infectious complications in heart transplant recipients with combined low dose cyclosporine, azathioprine and prednisolone (triple drug) immunosuppression.
    Transplantation proceedings, 1989, Volume: 21, Issue:1 Pt 3

    Topics: Azathioprine; Bacterial Infections; Candidiasis; Cause of Death; Drug Administration Schedule; Drug

1989
The incidence of Kaposi sarcoma in renal transplant patients and its relation to immunosuppression.
    Transplantation proceedings, 1989, Volume: 21, Issue:1 Pt 3

    Topics: Adult; Azathioprine; Cyclosporins; Female; Humans; Kidney Transplantation; Male; Middle Aged; Opport

1989
Late cellular rejection in renal transplant recipients.
    Transplantation, 1986, Volume: 41, Issue:2

    Topics: Adolescent; Adult; Antilymphocyte Serum; Azathioprine; Escherichia coli Infections; Female; Follow-U

1986
Improved outcome of renal transplantation with cyclosporine compared with azathioprine--experience in 33 recipients followed for over one year.
    The Japanese journal of surgery, 1986, Volume: 16, Issue:3

    Topics: Adolescent; Adult; Azathioprine; Bacterial Infections; Child; Cyclosporins; Female; Follow-Up Studie

1986
Infections in ciclosporin-treated patients.
    Contributions to nephrology, 1986, Volume: 51

    Topics: Azathioprine; Bacterial Infections; Cyclosporins; Humans; Infections; Kidney Transplantation; Mycose

1986
Infection in kidney transplantation.
    Surgery, 1971, Volume: 70, Issue:3

    Topics: Adolescent; Adult; Antilymphocyte Serum; Azathioprine; Child; Child, Preschool; Dactinomycin; Female

1971
Prolonged immunological disorder terminating in hematological malignancy: A human analogue of animal disease?
    Annals of internal medicine, 1970, Volume: 72, Issue:5

    Topics: Aged; Animal Diseases; Animals; Autoimmune Diseases; Azathioprine; Blood Protein Disorders; Blood Pr

1970
Selective action of azathioprine on T cells.
    Transplantation proceedings, 1973, Volume: 5, Issue:1

    Topics: Animals; Azathioprine; Bacterial Infections; Cell Migration Inhibition; Chromium Isotopes; Erythrocy

1973
Tumour development following immunosuppression.
    Proceedings of the Royal Society of Medicine, 1970, Volume: 63, Issue:10

    Topics: Adult; Animals; Antilymphocyte Serum; Azathioprine; Child; Cricetinae; Female; Humans; Immunity, Cel

1970
[Viral complications of renal transplantation].
    Bruxelles medical, 1971, Volume: 51, Issue:11

    Topics: Azathioprine; Cytarabine; Cytomegalovirus; DNA Viruses; DNA, Viral; Hepatitis A; Hepatitis B virus;

1971
Human polyomavirus infection in renal allograft recipients.
    British medical journal, 1973, Aug-18, Volume: 3, Issue:5876

    Topics: Adolescent; Adult; Antibody Formation; Azathioprine; Child; Cyclophosphamide; Female; Hemagglutinati

1973
The nitroblue-tetrazolium dye test and infection in the renal patient.
    American heart journal, 1973, Volume: 86, Issue:2

    Topics: Azathioprine; Bacterial Infections; Coloring Agents; Diagnosis, Differential; Graft Rejection; Human

1973
[Infectious pulmonary complications observed after renal transplantation (analysis of 104 cases)].
    Annales de medecine interne, 1973, Volume: 124, Issue:2

    Topics: Azathioprine; Bacterial Infections; Immunosuppressive Agents; Kidney Transplantation; Lung Diseases;

1973
Factors in infectious complications following cadaver renal transplantation.
    Proceedings of the Clinical Dialysis and Transplant Forum, 1973, Volume: 3

    Topics: Animals; Antilymphocyte Serum; Azathioprine; Bacterial Infections; Cadaver; Horses; Humans; Immunosu

1973
Renal disease in (NZB x NZW) F1 mice treated with antilymphocytic antibody. II. Effects of restoration with isogeneic, allogeneic, and xenogeneic lymphoid cells.
    Clinical and experimental immunology, 1970, Volume: 6, Issue:6

    Topics: Acute Disease; Animals; Antigen-Antibody Complex; Antilymphocyte Serum; Azathioprine; Basement Membr

1970
Infectious complications after cardiac transplantation in man.
    Annals of internal medicine, 1971, Volume: 74, Issue:1

    Topics: Adult; Amphotericin B; Antilymphocyte Serum; Azathioprine; Dactinomycin; Female; Heart Transplantati

1971
Progressive multifocal leukoencephalopathy after renal transplantation. Demonstration of Papova-like virions.
    Annals of internal medicine, 1971, Volume: 75, Issue:1

    Topics: Adult; Autopsy; Azathioprine; Brain; Demyelinating Diseases; Encephalitis; Female; Gliosis; Humans;

1971
Clinical experience with cardiac transplantation: retrospective considerations.
    Cardiovascular clinics, 1971, Volume: 2, Issue:3

    Topics: Adult; Azathioprine; Bacterial Infections; Cadaver; Graft Rejection; Heart; Heart Transplantation; H

1971
[Practical use of immunosuppressive and cytostatic drugs in dermatological diseases].
    Minerva medica, 1970, Jul-11, Volume: 61, Issue:55

    Topics: Antineoplastic Agents; Azathioprine; Condylomata Acuminata; Fluorouracil; Humans; Immunosuppressive

1970
Viruses and immunosuppressant drugs.
    British medical journal, 1970, Sep-26, Volume: 3, Issue:5725

    Topics: Azathioprine; Child; Child, Preschool; Hepatitis A; Hepatitis B Antigens; Humans; Liver; Microscopy,

1970