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azathioprine and Uveomeningoencephalitic Syndrome

azathioprine has been researched along with Uveomeningoencephalitic Syndrome in 18 studies

Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.

Uveomeningoencephalitic Syndrome: A syndrome characterized by bilateral granulomatous UVEITIS with IRITIS and secondary GLAUCOMA, premature ALOPECIA, symmetrical VITILIGO, poliosis circumscripta (a strand of depigmented hair), HEARING DISORDERS, and meningeal signs (neck stiffness and headache). Examination of the cerebrospinal fluid reveals a pattern consistent with MENINGITIS, ASEPTIC. (Adams et al., Principles of Neurology, 6th ed, p748; Surv Ophthalmol 1995 Jan;39(4):265-292)

Research Excerpts

ExcerptRelevanceReference
" After prednisolone and methotrexate failed to have the desired effect, he was treated with azathioprine, which caused pancytopenia, and manifested as fever with positive blood culture for a coagulase-negative staphylococcus infection."8.12Azathioprine Induced Pancytopenia in a Patient with Vogt-Koyanagi-Harada Disease: A Case Report. ( Barman, P; Bhattarai, S; Khatri, S; Manandhar, D; Pyakurel, S; Regmi, S; Singh, AK, 2022)
"BACKGROUND The aim of this study was to describe the case of a 27-year-old woman who developed Vogt-Koyanagi-Harada (VKH) disease in the 13th week of pregnancy, who was treated with high-dose oral corticosteroids and azathioprine due to its persistent course."7.91Azathioprine During the First Trimester of Pregnancy in a Patient with Vogt-Koyanagi-Harada Disease: A Multimodal Imaging Follow-Up Study. ( Aguilera Partida, JA; Ingolotti, M; Roig Melo-Granados, EA; Ruiz García, H; Schlaen, BA, 2019)
"A VKH disease patient, well controlled on azathioprine therapy, presented a uveitis relapse eleven days after the first vaccination for COVID-19."4.12Vogt-Koyanagi-Harada Relapse after COVID-19 Vaccination. ( Accorinti, M; Manni, P; Saturno, MC, 2022)
" After prednisolone and methotrexate failed to have the desired effect, he was treated with azathioprine, which caused pancytopenia, and manifested as fever with positive blood culture for a coagulase-negative staphylococcus infection."4.12Azathioprine Induced Pancytopenia in a Patient with Vogt-Koyanagi-Harada Disease: A Case Report. ( Barman, P; Bhattarai, S; Khatri, S; Manandhar, D; Pyakurel, S; Regmi, S; Singh, AK, 2022)
"BACKGROUND The aim of this study was to describe the case of a 27-year-old woman who developed Vogt-Koyanagi-Harada (VKH) disease in the 13th week of pregnancy, who was treated with high-dose oral corticosteroids and azathioprine due to its persistent course."3.91Azathioprine During the First Trimester of Pregnancy in a Patient with Vogt-Koyanagi-Harada Disease: A Multimodal Imaging Follow-Up Study. ( Aguilera Partida, JA; Ingolotti, M; Roig Melo-Granados, EA; Ruiz García, H; Schlaen, BA, 2019)
"To investigate the effectiveness, visual outcome, and prognostic factors of Vogt-Koyanagi-Harada (VKH) disease treatment with a reduced dose of corticosteroids combined with immunosuppressive agents."1.48Novel treatment regimen of Vogt-Koyanagi-Harada disease with a reduced dose of corticosteroids combined with immunosuppressive agents. ( Du, L; Kijlstra, A; Liang, L; Qi, J; Wang, C; Wu, L; Yang, P; Ye, Z; Zhou, Q, 2018)
"At the time of recurrence, four patients were on maintenance dose (5-10 mg/day) of oral corticosteroid while the remaining three were off treatment."1.35Posterior segment recurrences in Vogt-Koyanagi-Harada disease. ( Gupta, A; Gupta, V; Sachdev, N; Singh, R, 2008)
"We report a Chinese man with VKH syndrome presenting with multiple cranial nerve palsy and bilateral pan-uveitis, who developed disseminated high-grade B cell lymphoma after 3-year treatment with azathioprine."1.33High-grade lymphoma after azathioprine treatment for Vogt-Kaganayi-Harada syndrome. ( Au, WY; Ho, SL; Hon, C; Ma, ES; Trendell-Smith, NJ, 2005)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19901 (5.56)18.7374
1990's1 (5.56)18.2507
2000's5 (27.78)29.6817
2010's6 (33.33)24.3611
2020's5 (27.78)2.80

Authors

AuthorsStudies
Accorinti, M1
Saturno, MC1
Manni, P1
Khatri, S2
Regmi, S1
Pyakurel, S1
Bhattarai, S1
Barman, P1
Manandhar, D1
Singh, AK1
Bajgai, P1
Sharma, A1
Singh, R2
Khochtali, S1
Mahjoub, A1
Dridi, T1
Ksiaa, I1
Abroug, N1
Khairallah, M1
Silpa-Archa, S1
Ittharat, W1
Chotcomwongse, P1
Preble, JM1
Foster, CS2
Yang, P1
Ye, Z1
Du, L1
Zhou, Q1
Qi, J1
Liang, L1
Wu, L1
Wang, C1
Kijlstra, A1
Ingolotti, M1
Schlaen, BA1
Roig Melo-Granados, EA1
Ruiz García, H1
Aguilera Partida, JA1
Wand, K1
Abraham, S1
Loos, D1
Stumpfe, S1
Lohmann, C1
Maier, M1
Feucht, N1
Cuchacovich, M2
Solanes, F1
Díaz, G2
Cermenati, T1
Avila, S1
Verdaguer, J2
Verdaguer, JI2
Carpentier, C1
Stopel, J1
Rojas, B2
Traipe, L1
Gallardo, P1
Sabugo, F1
Zanoli, M1
Merino, G2
Villarroel, F2
Sifuentes Giraldo, WA1
de la Puente Bujidos, C1
de Blas Beorlegui, G1
López San Román, A1
Peña Arrebola, A1
Arcinue, CA1
Radwan, A1
Lebanan, MO1
Kohnen, EM1
Pansdorf, Y1
Zubcov, A1
Hon, C1
Ho, SL1
Ma, ES1
Trendell-Smith, NJ1
Au, WY1
Agarwal, M1
Ganesh, SK1
Biswas, J1
Pacheco, P1
Stoppel, J1
Sachdev, N1
Gupta, V1
Gupta, A1
Menger, H1
Neukäter, W1
Kroll, S1
Jörg, J1
Sundmacher, R1

Trials

2 trials available for azathioprine and Uveomeningoencephalitic Syndrome

ArticleYear
Comparison of the clinical efficacy of two different immunosuppressive regimens in patients with chronic vogt-koyanagi-harada disease.
    Ocular immunology and inflammation, 2010, Volume: 18, Issue:3

    Topics: Adolescent; Adult; Azathioprine; Child; Child, Preschool; Chronic Disease; Cyclosporine; Dose-Respon

2010
[Role of Azathioprine in steroid resistant non infectious ocular inflammatory diseases].
    Revista medica de Chile, 2007, Volume: 135, Issue:6

    Topics: Adolescent; Adult; Aged; Azathioprine; Choroid Diseases; Drug Resistance; Drug Therapy, Combination;

2007

Other Studies

16 other studies available for azathioprine and Uveomeningoencephalitic Syndrome

ArticleYear
Vogt-Koyanagi-Harada Relapse after COVID-19 Vaccination.
    Ocular immunology and inflammation, 2022, Volume: 30, Issue:5

    Topics: Adrenal Cortex Hormones; Azathioprine; Chronic Disease; COVID-19; COVID-19 Vaccines; Female; Humans;

2022
Azathioprine Induced Pancytopenia in a Patient with Vogt-Koyanagi-Harada Disease: A Case Report.
    JNMA; journal of the Nepal Medical Association, 2022, Oct-01, Volume: 60, Issue:254

    Topics: Azathioprine; Humans; Immunosuppressive Agents; Male; Middle Aged; Pancytopenia; Prednisolone; Uveom

2022
Disseminated Tubercular Granulomas Associated with the Use of Azathioprine.
    Ocular immunology and inflammation, 2021, Jul-04, Volume: 29, Issue:5

    Topics: Antitubercular Agents; Azathioprine; Choroid Diseases; Coloring Agents; Female; Fluorescein Angiogra

2021
Cytomegalovirus retinitis following corticosteroid overdose for Vogt-Koyanagi-Harada disease.
    Indian journal of ophthalmology, 2020, Volume: 68, Issue:9

    Topics: Adult; Azathioprine; Cytomegalovirus Retinitis; Female; Humans; Immunosuppressive Agents; Uveomening

2020
Analysis of Three-Dimensional Choroidal Volume with Enhanced Depth Imaging Findings in Patients with Recurrent Vogt-Koyanagi-Harada Disease.
    Current eye research, 2021, Volume: 46, Issue:7

    Topics: Adult; Aged; Azathioprine; Choroid; Cyclosporine; Female; Fluorescein Angiography; Humans; Imaging,

2021
Novel treatment regimen of Vogt-Koyanagi-Harada disease with a reduced dose of corticosteroids combined with immunosuppressive agents.
    Current eye research, 2018, Volume: 43, Issue:2

    Topics: Acute Disease; Azathioprine; Cyclophosphamide; Cyclosporine; Drug Therapy, Combination; Fluorescein

2018
Azathioprine During the First Trimester of Pregnancy in a Patient with Vogt-Koyanagi-Harada Disease: A Multimodal Imaging Follow-Up Study.
    The American journal of case reports, 2019, Mar-07, Volume: 20

    Topics: Adult; Angiography; Azathioprine; Female; Humans; Immunosuppressive Agents; Multimodal Imaging; Preg

2019
[Long-term course of immunosuppressive therapy of Vogt-Koyanagi-Harada syndrome].
    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 2015, Volume: 112, Issue:10

    Topics: Adrenal Cortex Hormones; Adult; Azathioprine; Cyclosporine; Drug Substitution; Female; Follow-Up Stu

2015
Herpes zoster motor neuropathy in a patient with previous motor paresis secondary to Vogt-Koyanagi-Harada disease.
    American journal of physical medicine & rehabilitation, 2013, Volume: 92, Issue:4

    Topics: Adult; Azathioprine; Colitis, Ulcerative; Disease Progression; Electromyography; Female; Herpes Zost

2013
Comparison of two different combination immunosuppressive therapies in the treatment of Vogt-Koyonagi-Harada syndrome.
    Ocular immunology and inflammation, 2013, Volume: 21, Issue:1

    Topics: Adult; Azathioprine; Cyclosporine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fema

2013
[Recurrent uveitis with bilateral exudative retinal detachment. 10-year-old boy with bilaterally impaired vision and eye pain. Vogt-Koyanagi-Harada syndrome].
    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 2004, Volume: 101, Issue:4

    Topics: Azathioprine; Child; Diagnosis, Differential; Dose-Response Relationship, Drug; Drug Therapy, Combin

2004
High-grade lymphoma after azathioprine treatment for Vogt-Kaganayi-Harada syndrome.
    Leukemia & lymphoma, 2005, Volume: 46, Issue:2

    Topics: Adult; Azathioprine; Carcinogens; Cranial Nerve Diseases; Humans; Immunophenotyping; Lymph Nodes; Ly

2005
Triple agent immunosuppressive therapy in Vogt-Koyanagi-Harada syndrome.
    Ocular immunology and inflammation, 2006, Volume: 14, Issue:6

    Topics: Adult; Azathioprine; Cyclosporine; Drug Therapy, Combination; Female; Follow-Up Studies; Fundus Ocul

2006
Posterior segment recurrences in Vogt-Koyanagi-Harada disease.
    International ophthalmology, 2008, Volume: 28, Issue:5

    Topics: Adult; Azathioprine; Drug Therapy, Combination; Female; Fluorescein Angiography; Glucocorticoids; Hu

2008
[The Vogt-Koyanagi-Harada uveomeningoencephalitic syndrome].
    Der Nervenarzt, 1994, Volume: 65, Issue:8

    Topics: Adult; Autoimmune Diseases; Azathioprine; Cortisone; Diagnosis, Differential; Dose-Response Relation

1994
[Diagnosis of Vogt-Koyanagi-Harada-syndrome (uveoencephalitis) (author's transl)].
    Klinische Monatsblatter fur Augenheilkunde, 1975, Volume: 166, Issue:4

    Topics: Adult; Azathioprine; Diagnosis, Differential; Female; Fundus Oculi; Germany, West; Glucocorticoids;

1975