azathioprine has been researched along with Trypanosomiasis, African in 2 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Trypanosomiasis, African: A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces African sleeping sickness. Nagana is a rapidly fatal trypanosomiasis of horses and other animals.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Drug treatment of late-stage human African Trypanosomiasis (HAT) in which the central nervous system (CNS) is involved may be complicated by a severe post-treatment reactive encephalopathy (PTRE) which can be fatal in up to 10% of cases." | 1.30 | The pathogenesis and modulation of the post-treatment reactive encephalopathy in a mouse model of Human African Trypanosomiasis. ( Kennedy, PG, 1999) |
| "The treatment of human African sleeping sickness is complicated by a post-treatment meningoencephalitis that may be fatal." | 1.28 | The use of azathioprine to ameliorate post-treatment encephalopathy associated with African trypanosomiasis. ( Hunter, CA; Jennings, FW; Kennedy, PG; Murray, M, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kennedy, PG | 2 |
| Hunter, CA | 1 |
| Jennings, FW | 1 |
| Murray, M | 1 |
2 other studies available for azathioprine and Trypanosomiasis, African
| Article | Year |
|---|---|
The pathogenesis and modulation of the post-treatment reactive encephalopathy in a mouse model of Human African Trypanosomiasis.
Topics: Analgesics; Animals; Azathioprine; Disease Models, Animal; Eflornithine; Encephalitis; Hippocampus; | 1999 |
The use of azathioprine to ameliorate post-treatment encephalopathy associated with African trypanosomiasis.
Topics: Animals; Azathioprine; Brain Diseases; Diminazene; Disease Models, Animal; Female; Mice; Mice, Inbre | 1992 |