azathioprine has been researched along with Severe Combined Immunodeficiency in 3 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Severe Combined Immunodeficiency: Group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. It is inherited as an X-linked or autosomal recessive defect. Mutations occurring in many different genes cause human Severe Combined Immunodeficiency (SCID).
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Carol, HA | 1 |
| Ochfeld, EN | 1 |
| Ahmed, A | 1 |
| Taşkıran, EZ | 1 |
| Sönmez, HE | 1 |
| Ayvaz, DÇ | 1 |
| Koşukcu, C | 1 |
| Batu, ED | 1 |
| Esenboğa, S | 1 |
| Topaloğlu, R | 1 |
| Orhan, D | 1 |
| Bilginer, Y | 1 |
| Alikaşifoğlu, M | 1 |
| Özen, S | 1 |
| Tezcan, İ | 1 |
| MATHE, G | 1 |
| AMIEL, JL | 1 |
| SCHWARZENBERG, L | 1 |
| CATTAN, A | 1 |
| SCHNEIDER, M | 1 |
| DEVRIES, MJ | 1 |
| TUBIANA, M | 1 |
| LALANNE, C | 1 |
| BINET, JL | 1 |
| PAPIERNIK, M | 1 |
| SEMAN, G | 1 |
| MATSUKURA, M | 1 |
| MERY, AM | 1 |
| SCHWARZMANN, V | 1 |
| FLAISLER, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prophylactic Infusion of Donor Lymphocytes in Cord Blood Transplantation[NCT02328885] | Phase 1/Phase 2 | 17 participants (Actual) | Interventional | 2014-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for azathioprine and Severe Combined Immunodeficiency
| Article | Year |
|---|---|
In-utero exposure to immunosuppressive medications resulting in abnormal newborn screening for severe combined immunodeficiency: a case series on natural history and management.
Topics: Actins; Azathioprine; Female; Fingolimod Hydrochloride; Humans; Hydroxychloroquine; Infant; Infant, | 2022 |
Hypomorphic RAG1 defect in a child presented with pulmonary hemorrhage and digital necrosis.
Topics: Anemia, Hemolytic; Azathioprine; Child, Preschool; Consanguinity; Cyclophosphamide; Diagnostic Error | 2018 |
SUCCESSFUL ALLOGENIC BONE MARROW TRANSPLANTATION IN MAN: CHIMERISM, INDUCED SPECIFIC TOLERANCE AND POSSIBLE ANTI-LEUKEMIC EFFECTS.
Topics: Antineoplastic Agents; Azathioprine; Bone Marrow Transplantation; Chimerism; Electrons; Genetic Dise | 1965 |