azathioprine has been researched along with Sarcoidosis, Pulmonary in 15 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Sarcoidosis, Pulmonary: Sarcoidosis affecting predominantly the lungs, the site most frequently involved and most commonly causing morbidity and mortality in sarcoidosis. Pulmonary sarcoidosis is characterized by sharply circumscribed granulomas in the alveolar, bronchial, and vascular walls, composed of tightly packed cells derived from the mononuclear phagocyte system. The clinical symptoms when present are dyspnea upon exertion, nonproductive cough, and wheezing. (Cecil Textbook of Medicine, 19th ed, p431)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sarcoidosis is a systemic inflammatory disease, characterised by granuloma formation upon an unknown trigger in genetically predisposed individuals." | 1.72 | Sarcoidosis - a multisystem disease. ( Böni, C; Brutsche, M; Daccord, C; Distler, O; Elsener, D; Franzen, DP; Funke-Chambour, M; Gruner, C; Hayward-Könnecke, H; Hostettler, KE; Kolios, AGA; Kündig, T; Nilsson, J; Ribi, C; Seebach, JD; Seeger, H; Vrugt, B, 2022) |
| "Steroids remain the first-choice therapeutic in sarcoidosis; however, long-term use is associated with toxicity." | 1.39 | Methotrexate vs azathioprine in second-line therapy of sarcoidosis. ( Deneer, VHM; Grutters, JC; Thomeer, M; van Moorsel, CHM; Veltkamp, M; Vorselaars, ADM; Vorselaars, VMM; Wuyts, WA; Zanen, P, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (26.67) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 7 (46.67) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Franzen, DP | 1 |
| Brutsche, M | 1 |
| Nilsson, J | 1 |
| Böni, C | 1 |
| Daccord, C | 1 |
| Distler, O | 1 |
| Elsener, D | 1 |
| Funke-Chambour, M | 1 |
| Gruner, C | 1 |
| Hayward-Könnecke, H | 1 |
| Hostettler, KE | 1 |
| Kündig, T | 1 |
| Ribi, C | 1 |
| Seebach, JD | 1 |
| Seeger, H | 1 |
| Vrugt, B | 1 |
| Kolios, AGA | 1 |
| Lee, HN | 1 |
| Kim, JI | 1 |
| Won, K | 1 |
| Song, R | 1 |
| Vorselaars, ADM | 1 |
| Wuyts, WA | 1 |
| Vorselaars, VMM | 1 |
| Zanen, P | 1 |
| Deneer, VHM | 1 |
| Veltkamp, M | 1 |
| Thomeer, M | 1 |
| van Moorsel, CHM | 1 |
| Grutters, JC | 1 |
| Kotze, PG | 1 |
| de Barcelos, IF | 1 |
| da Silva Kotze, LM | 1 |
| Korsten, P | 1 |
| Mirsaeidi, M | 1 |
| Sweiss, NJ | 2 |
| Franzen, D | 1 |
| Mathys, C | 1 |
| Vesper, J | 1 |
| Malzkorn, B | 1 |
| Bohlen, H | 1 |
| Seitz, RJ | 1 |
| Bolat, S | 1 |
| Berding, G | 1 |
| Dengler, R | 1 |
| Stangel, M | 1 |
| Trebst, C | 1 |
| Skowasch, D | 1 |
| Pabst, S | 1 |
| Wilhelm, K | 1 |
| Grohé, C | 1 |
| Baughman, RP | 3 |
| Nunes, H | 1 |
| Lower, EE | 2 |
| Jindal, SK | 1 |
| Kirsten, D | 1 |
| Lewis, SJ | 1 |
| Ainslie, GM | 1 |
| Bateman, ED | 1 |
| Müller-Quernheim, J | 1 |
| Kienast, K | 1 |
| Held, M | 1 |
| Pfeifer, S | 1 |
| Costabel, U | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Endobronchial Mucosal Biopsy in Patients With Suspected Pulmonary Sarcoidosis[NCT04904939] | 20 participants (Actual) | Interventional | 2020-05-15 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for azathioprine and Sarcoidosis, Pulmonary
| Article | Year |
|---|---|
Nonsteroidal therapy of sarcoidosis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Biological Products; Humans; Immunosuppressiv | 2013 |
Established and experimental medical therapy of pulmonary sarcoidosis.
Topics: Adalimumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Azathioprine; Clinical Trials | 2013 |
Therapeutic options for sarcoidosis: new and old.
Topics: Adjuvants, Immunologic; Anti-Bacterial Agents; Azathioprine; Disease Progression; Glucocorticoids; H | 2002 |
Practical issues and challenges in the diagnosis and treatment of pulmonary sarcoidosis.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Azathioprine; Cyclophosphamide; Humans; Immunosup | 2007 |
1 trial available for azathioprine and Sarcoidosis, Pulmonary
| Article | Year |
|---|---|
Treatment of chronic sarcoidosis with an azathioprine/prednisolone regimen.
Topics: Adult; Anti-Inflammatory Agents; Azathioprine; Bronchoalveolar Lavage Fluid; Drug Therapy, Combinati | 1999 |
10 other studies available for azathioprine and Sarcoidosis, Pulmonary
| Article | Year |
|---|---|
Sarcoidosis - a multisystem disease.
Topics: Azathioprine; Humans; Immunosuppressive Agents; Quality of Life; Sarcoidosis; Sarcoidosis, Pulmonary | 2022 |
Atypical CT findings of pulmonary sarcoidosis: A case report.
Topics: Azathioprine; Female; Glucocorticoids; Humans; Immunosuppressive Agents; Lymphadenopathy; Middle Age | 2018 |
Methotrexate vs azathioprine in second-line therapy of sarcoidosis.
Topics: Azathioprine; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Forced Expiratory Volume; | 2013 |
Sarcoidosis during therapy with adalimumab in a Crohn's disease patient: a paradoxical effect.
Topics: Adalimumab; Adult; Antibodies, Monoclonal, Humanized; Azathioprine; Biopsy, Needle; Colectomy; Crohn | 2013 |
[Progressive multifocal leukoencephalopathy following azathioprine and steroid treatment of pulmonary sarcoid disease].
Topics: Azathioprine; Humans; Immunosuppressive Agents; Leukoencephalopathy, Progressive Multifocal; Male; M | 2015 |
Fluorodeoxyglucose positron emission tomography (FDG-PET) is useful in the diagnosis of neurosarcoidosis.
Topics: Anti-Inflammatory Agents; Azathioprine; Diagnosis, Differential; Encephalitis; Fluorodeoxyglucose F1 | 2009 |
[Diabetes insipidus due to neurosarcoidosis].
Topics: Adult; Anti-Inflammatory Agents; Antidiuretic Agents; Azathioprine; Biopsy; Central Nervous System D | 2011 |
[Sarcoidosis in Germany. Analysis of a questionnaire survey in 1992 of patients of the German Sarcoidosis Group].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Azathioprine; Child; Cortisone; Diagnosis, Differential; | 1995 |
Efficacy of azathioprine as second-line treatment in pulmonary sarcoidosis.
Topics: Adrenal Cortex Hormones; Adult; Aged; Azathioprine; Dose-Response Relationship, Drug; Female; Humans | 1999 |
New treatment for sarcoidosis: where's the proof?
Topics: Anti-Inflammatory Agents; Azathioprine; Clinical Trials as Topic; Glucocorticoids; Humans; Immunosup | 1999 |