Page last updated: 2024-10-23

azathioprine and Retinal Vasculitis

azathioprine has been researched along with Retinal Vasculitis in 19 studies

Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.

Retinal Vasculitis: Inflammation of the retinal vasculature with various causes including infectious disease; LUPUS ERYTHEMATOSUS, SYSTEMIC; MULTIPLE SCLEROSIS; BEHCET SYNDROME; and CHORIORETINITIS.

Research Excerpts

ExcerptRelevanceReference
"An immunocompetent, 25-year-old gentleman with bilateral chronic uveitis presented to various uveitis clinics at different points of time with documented typical clinical features of Toxoplasma Chorioretinitis (Headlight in fog appearance), Behcet's Disease (Hypopyon with peripheral retinal vasculitis), and Presumed Ocular Tuberculosis (Granulomatous Intermediate Uveitis with positive Interferon-gamma release assay) and had been treated with anti-toxoplasma drugs, oral prednisolone, and immunomodulation with oral Mycophenolate/oral Azathioprine to no avail."3.96Isolated intraocular histiocytosis-A rarely reported entity masquerading clinically as uveitis. ( Dudani, AI; Moreker, MR; Patel, K; Sharma, TR; Smruti, BK, 2020)
"Ocular lesions, the main morbidity of Behcet's disease (BD), are the most difficult to treat."2.75Rituximab in intractable ocular lesions of Behcet's disease; randomized single-blind control study (pilot study). ( Akhlaghi, M; Chams-Davatchi, C; Davatchi, F; Faezi, T; Naderi, N; Nadji, A; Rezaipoor, M; Sadeghi-Abdollahi, B; Shahram, F; Shams, H, 2010)
"Adamantiades-Behcet's disease (ABD) is a chronic recurrent vasculitis whose aetiology is still unclear."2.43[Adamantiades-Behcet's disease]. ( Krause, L, 2005)
"Retinal vasculitis was noted in majority of affected eyes and specifically arteritis was noticed in 32/57(56%)."1.51Ocular Manifestations and Visual Outcomes of Behçet's Uveitis in a Thai population. ( Kunavisarut, P; Pathanapitoon, K; Rothova, A; Saravuttikul, FA, 2019)
"Azathioprine was used at 2-3 mg/kg daily."1.40Combination of pulse cyclophosphamide and azathioprine in ocular manifestations of Behcet's disease: longitudinal study of up to 10 years. ( Akhlaghi, M; Ashofteh, F; Chams-Davatchi, C; Davatchi, F; Faezi, T; Ghodsi, Z; Mohtasham, N; Nadji, A; Sadeghi Abdollahi, B; Shahram, F; Shams, H, 2014)
"Even with proper immunosuppressive treatment, SLE can relapse."1.37Lupus relapse presented as frosted branch retinal angiitis: case report. ( Arellanes-Garcia, L; Cornejo-Ballesteros, H; Hernandez-Da Mota, SE; Melgoza-del-Angel, C; Recillas-Gispert, C; Sanchez-Gonzalez, R; Teran-Estrada, L, 2011)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (21.05)29.6817
2010's12 (63.16)24.3611
2020's3 (15.79)2.80

Authors

AuthorsStudies
B Singh, S1
Kanakath, AV1
Saravanan, V1
K S, J1
V, N1
Kawali, A1
Bavaharan, B1
Sanjay, S1
Mohan, A1
Mahendradas, P1
Shetty, B1
Moreker, MR1
Dudani, AI1
Sharma, TR1
Patel, K1
Smruti, BK1
Matsuura, M1
Taniguchi, Y1
Terada, Y1
Mohammadi, M1
Shahram, F4
Shams, H3
Akhlaghi, M3
Ashofteh, F2
Davatchi, F4
Starr, MR1
Smith, WM1
Postlethwaite, B1
Wynn, HG1
Pattanaik, D1
Ost, S1
MacDonald, CB1
Walton, RC1
Kim, S1
Myers, LK1
Brown Lobbins, M1
Pathanapitoon, K1
Kunavisarut, P1
Saravuttikul, FA1
Rothova, A1
Majumder, PD1
Sitaula, RK1
Biswas, J1
Sadeghi Abdollahi, B1
Nadji, A3
Chams-Davatchi, C2
Faezi, T2
Ghodsi, Z1
Mohtasham, N1
Tabbara, KF1
Al-Hemidan, AI1
Cantoni, N1
Meyer, P1
Katan, M1
Kappos, L1
Hess, C1
Daikeler, T1
Donghi, D1
Mainetti, C1
Rezaipoor, M1
Sadeghi-Abdollahi, B1
Naderi, N1
Jackson, TE1
Pathak, S1
Doran, RM1
Hernandez-Da Mota, SE1
Arellanes-Garcia, L1
Recillas-Gispert, C1
Cornejo-Ballesteros, H1
Melgoza-del-Angel, C1
Teran-Estrada, L1
Sanchez-Gonzalez, R1
Chams, H1
Jamshidi, A1
Akbarian, M1
Gharibdoost, F1
Krause, L1
Boura, P1
Tselios, K1
Kamali, S1
Skendros, P1
Sarantopoulos, A1
Topouzis, F1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Low-dose IL-2 Treatment on Behcet's Disease[NCT04065672]Phase 215 participants (Anticipated)Interventional2019-11-12Recruiting
A Double Blind Cross Over Clinical Trial to Determine Colchicine Efficacy in Behcet's Disease[NCT00700297]Phase 2169 participants (Actual)Interventional2002-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for azathioprine and Retinal Vasculitis

ArticleYear
[Adamantiades-Behcet's disease].
    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 2005, Volume: 102, Issue:4

    Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antibodies, Monoclonal; Azathioprine; Behcet Synd

2005

Trials

3 trials available for azathioprine and Retinal Vasculitis

ArticleYear
High-dose intravenous steroid pulse therapy in ocular involvement of Behcet's disease: a pilot double-blind controlled study.
    International journal of rheumatic diseases, 2017, Volume: 20, Issue:9

    Topics: Administration, Intravenous; Adult; Azathioprine; Behcet Syndrome; Cyclophosphamide; Double-Blind Me

2017
Rituximab in intractable ocular lesions of Behcet's disease; randomized single-blind control study (pilot study).
    International journal of rheumatic diseases, 2010, Volume: 13, Issue:3

    Topics: Adolescent; Adult; Antibodies, Monoclonal, Murine-Derived; Azathioprine; Behcet Syndrome; Cyclophosp

2010
Azathioprine and low dose pulse cyclophosphamide in severe ocular lesions of Behçet's disease. A preliminary report.
    Advances in experimental medicine and biology, 2003, Volume: 528

    Topics: Azathioprine; Behcet Syndrome; Cyclophosphamide; Drug Administration Schedule; Drug Therapy, Combina

2003

Other Studies

15 other studies available for azathioprine and Retinal Vasculitis

ArticleYear
A Case of Idiopathic Retinitis Vasculitis Aneurysms and Neuroretinitis (IRVAN) Treated with Adalimumab.
    Ocular immunology and inflammation, 2023, Volume: 31, Issue:3

    Topics: Adalimumab; Adolescent; Aneurysm; Azathioprine; Chorioretinitis; Female; Fluorescein Angiography; Hu

2023
A Long-Term Follow-up of Retinal Vasculitis - Do They Develop Systemic Disease?
    Ocular immunology and inflammation, 2020, Nov-16, Volume: 28, Issue:8

    Topics: Adolescent; Adult; Aged; Antitubercular Agents; Azathioprine; Colitis, Ulcerative; Cyclosporine; Dru

2020
Isolated intraocular histiocytosis-A rarely reported entity masquerading clinically as uveitis.
    Indian journal of ophthalmology, 2020, Volume: 68, Issue:9

    Topics: Adult; Azathioprine; Behcet Syndrome; Histiocytosis; Humans; Male; Retinal Vasculitis; Uveitis

2020
Retinal and Choroidal Detachment in Antineutrophil Cytoplasmic Antibody-Associated Scleritis and Retinal Vasculitis Mimicking Choroidal Tumor.
    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 2017, Volume: 23, Issue:4

    Topics: Aged, 80 and over; Antibodies, Antineutrophil Cytoplasmic; Antirheumatic Agents; Azathioprine; Choro

2017
A Teenage Girl With Aseptic Meningitis and Unilateral Blurry Vision.
    JAMA ophthalmology, 2017, 10-01, Volume: 135, Issue:10

    Topics: Adolescent; Azathioprine; Behcet Syndrome; Drug Therapy, Combination; Female; Glucocorticoids; Human

2017
Retinal Vasculitis and Choroidopathy in Pediatric-Onset Mixed Connective Tissue Disease.
    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 2017, Volume: 23, Issue:7

    Topics: Adolescent; Antibodies, Antinuclear; Azathioprine; Choroid Diseases; Cyclophosphamide; Diagnostic Te

2017
Ocular Manifestations and Visual Outcomes of Behçet's Uveitis in a Thai population.
    Ocular immunology and inflammation, 2019, Volume: 27, Issue:1

    Topics: Adolescent; Adult; Age of Onset; Azathioprine; Behcet Syndrome; Child; Drug Therapy, Combination; Fe

2019
Pediatric Eales Disease: An Indian Tertiary Eye Center Experience.
    Journal of pediatric ophthalmology and strabismus, 2018, Jul-01, Volume: 55, Issue:4

    Topics: Adolescent; Antitubercular Agents; Azathioprine; Child; Female; Follow-Up Studies; Glucocorticoids;

2018
Combination of pulse cyclophosphamide and azathioprine in ocular manifestations of Behcet's disease: longitudinal study of up to 10 years.
    International journal of rheumatic diseases, 2014, Volume: 17, Issue:4

    Topics: Azathioprine; Behcet Syndrome; Cyclophosphamide; Drug Resistance; Drug Therapy, Combination; Humans;

2014
Infliximab effects compared to conventional therapy in the management of retinal vasculitis in Behçet disease.
    American journal of ophthalmology, 2008, Volume: 146, Issue:6

    Topics: Adolescent; Adult; Anti-Inflammatory Agents; Antibodies, Monoclonal; Azathioprine; Behcet Syndrome;

2008
A confusing patient's history: small or large vessel vasculitis?
    Rheumatology international, 2010, Volume: 30, Issue:12

    Topics: Autoantibodies; Azathioprine; Conjunctivitis; Cyclophosphamide; Diagnosis, Differential; Drug Therap

2010
Infliximab for the treatment of refractory Adamantiades-Behçet disease with articular, intestinal, cerebral and ocular involvement.
    Dermatology (Basel, Switzerland), 2010, Volume: 220, Issue:3

    Topics: Adolescent; Antibodies, Monoclonal; Arthritis; Aspirin; Azathioprine; Behcet Syndrome; Chronic Disea

2010
Behçet disease presenting with frosted branch angiitis.
    Ocular immunology and inflammation, 2011, Volume: 19, Issue:1

    Topics: Arthritis; Azathioprine; Behcet Syndrome; Fundus Oculi; Hematocele; HLA-B Antigens; HLA-B51 Antigen;

2011
Lupus relapse presented as frosted branch retinal angiitis: case report.
    Ocular immunology and inflammation, 2011, Volume: 19, Issue:5

    Topics: Adolescent; Azathioprine; Female; Humans; Immunosuppressive Agents; Lupus Vasculitis, Central Nervou

2011
Concurrent relapsing central nervous system and ocular involvement in a case of life-threatening Adamantiades-Behçet Disease (ABD).
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2006, Volume: 27, Issue:6

    Topics: Acute Disease; Adrenal Cortex Hormones; Adult; Azathioprine; Behcet Syndrome; Cyclophosphamide; Cycl

2006