Page last updated: 2024-10-23

azathioprine and Respiratory Insufficiency

azathioprine has been researched along with Respiratory Insufficiency in 22 studies

Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.

Respiratory Insufficiency: Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)

Research Excerpts

ExcerptRelevanceReference
"Azathioprine is an established immunosuppressive agent in the treatment of myasthenia gravis."7.69[Myasthenic crisis caused by azathioprine-induced fever]. ( George, A; Nau, R; Tumani, H, 1997)
"Azathioprine is an established immunosuppressive agent in the treatment of myasthenia gravis."3.69[Myasthenic crisis caused by azathioprine-induced fever]. ( George, A; Nau, R; Tumani, H, 1997)
"Extended diagnostic measures revealed interstitial lung disease (ILD), polyserositis, polyarthritis and myopathy."1.51[Progressive respiratory failure and weakness in a 61-year-old woman]. ( Mahmud, M; Schnoor, U; Steinmetz, OM, 2019)
"We present 4 patients with CIDP who required respiratory assistance and mechanical ventilation."1.33Chronic inflammatory demyelinating polyneuropathy and respiratory failure. ( Henderson, RD; Sandroni, P; Wijdicks, EF, 2005)
"A patient developed respiratory failure after surgical removal of a recurrent thymoma, which necessitated removal of part of the diaphragm."1.28Unsuspected myasthenia gravis presenting as respiratory failure. ( Green, M; Laroche, C; Mier, A, 1990)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19908 (36.36)18.7374
1990's5 (22.73)18.2507
2000's3 (13.64)29.6817
2010's6 (27.27)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mahmud, M1
Schnoor, U1
Steinmetz, OM1
Cabral, DA1
Canter, DL1
Muscal, E1
Nanda, K1
Wahezi, DM1
Spalding, SJ1
Twilt, M1
Benseler, SM1
Campillo, S1
Charuvanij, S1
Dancey, P1
Eberhard, BA1
Elder, ME1
Hersh, A1
Higgins, GC1
Huber, AM1
Khubchandani, R1
Kim, S1
Klein-Gitelman, M1
Kostik, MM1
Lawson, EF1
Lee, T1
Lubieniecka, JM1
McCurdy, D1
Moorthy, LN1
Morishita, KA1
Nielsen, SM1
O'Neil, KM1
Reiff, A1
Ristic, G1
Robinson, AB1
Sarmiento, A1
Shenoi, S1
Toth, MB1
Van Mater, HA1
Wagner-Weiner, L1
Weiss, JE1
White, AJ1
Yeung, RS1
Hernández Pérez, JM1
Acosta Fernández, O1
Patel, HC1
Lauder, NN1
Griese, M1
Ripper, J1
Sibbersen, A1
Lohse, P2
Brasch, F1
Schams, A1
Pamir, A1
Schaub, B1
Muensterer, OJ1
Schön, C1
Glöckner-Pagel, J1
Nicolai, T1
Reiter, K1
Hector, A1
Spoon, KC1
Ramar, K1
Ishida, T1
Kotani, T1
Takeuchi, T1
Makino, S1
Henderson, RD1
Sandroni, P1
Wijdicks, EF1
Churg, A1
Müller, NL1
Silva, CI1
Wright, JL1
Theobald, I1
Limberg, B1
Magener, A1
Kauffmann, GW1
Tumani, H1
George, A1
Nau, R1
Stamenkovic, SA1
Alphonso, N1
Rice, P1
Madden, BP1
Cohen, JM1
Miller, A1
Spiera, H1
Vallet, B1
Fourrier, F1
Hurtevent, JF1
Parent, M1
Chopin, C1
Mier, A1
Laroche, C1
Green, M1
Kingston, WJ1
Moxley, RT1
Wildevuur, CR1
Benfield, JR1
Kreuzer, W1
Keiler, A1
Salem, G1
Göber, I1
Radaszkiewicz, T1
Mathews, JD1
Buckley, JD1
Gledhill, VX1
Kjellstrand, CM1
Simmons, RL1
Uranga, VM1
Buselmeier, TJ1
Najarian, JS1
Fuller, T1
Olsen, N1
Block, A1
Cade, J1
Haas, W1
Münzenmaier, R1
Loewe, KR1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Glucocorticoids Versus Placebo for the Treatment of Acute Exacerbation of Idiopathic Pulmonary Fibrosis: a Randomized Controlled Trial[NCT05674994]Phase 3110 participants (Anticipated)Interventional2023-10-26Recruiting
Cyclophosphamide Added to Corticosteroid in the Treatment of Acute Exacerbation of Idiopathic Pulmonary Fibrosis: a Placebo-controlled Randomized Trial[NCT02460588]Phase 3120 participants (Actual)Interventional2015-12-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for azathioprine and Respiratory Insufficiency

ArticleYear
Treatment of muscular dystrophies and inflammatory myopathies.
    Clinical neuropharmacology, 1986, Volume: 9, Issue:4

    Topics: Azathioprine; Clinical Trials as Topic; Dermatomyositis; Humans; Muscular Dystrophies; Myositis; Myo

1986
A review of 23 human lung transplantations by 20 surgeons.
    The Annals of thoracic surgery, 1970, Volume: 9, Issue:6

    Topics: Adolescent; Adult; Antilymphocyte Serum; Azathioprine; Dactinomycin; Female; Histocompatibility Test

1970

Trials

1 trial available for azathioprine and Respiratory Insufficiency

ArticleYear
Treatment of muscular dystrophies and inflammatory myopathies.
    Clinical neuropharmacology, 1986, Volume: 9, Issue:4

    Topics: Azathioprine; Clinical Trials as Topic; Dermatomyositis; Humans; Muscular Dystrophies; Myositis; Myo

1986

Other Studies

20 other studies available for azathioprine and Respiratory Insufficiency

ArticleYear
[Progressive respiratory failure and weakness in a 61-year-old woman].
    Der Internist, 2019, Volume: 60, Issue:2

    Topics: Amino Acyl-tRNA Synthetases; Antibodies, Antinuclear; Autoantibodies; Azathioprine; Combined Modalit

2019
Comparing Presenting Clinical Features in 48 Children With Microscopic Polyangiitis to 183 Children Who Have Granulomatosis With Polyangiitis (Wegener's): An ARChiVe Cohort Study.
    Arthritis & rheumatology (Hoboken, N.J.), 2016, Volume: 68, Issue:10

    Topics: Adolescent; Adrenal Cortex Hormones; Age Distribution; Antibodies, Antineutrophil Cytoplasmic; Asia;

2016
[Lung disease secondary to morphea en coup de sabre, a form of localized scleroderma].
    Archivos de bronconeumologia, 2009, Volume: 45, Issue:8

    Topics: Adrenal Cortex Hormones; Adult; Autoantibodies; Azathioprine; Drug Therapy, Combination; Facial Hemi

2009
The antisynthetase syndrome.
    The American journal of medicine, 2011, Volume: 124, Issue:9

    Topics: Adult; Anti-Inflammatory Agents; Antibodies, Antinuclear; Azathioprine; Cryptogenic Organizing Pneum

2011
Long-term follow-up and treatment of congenital alveolar proteinosis.
    BMC pediatrics, 2011, Aug-17, Volume: 11

    Topics: Adrenal Cortex Hormones; Azathioprine; Bronchoalveolar Lavage; Child; Female; Granulocyte-Macrophage

2011
Unexplained hypoxemia.
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2011, Dec-15, Volume: 7, Issue:6

    Topics: Ascorbic Acid; Azathioprine; Blood Gas Analysis; Dapsone; Female; Follow-Up Studies; Humans; Hyperca

2011
Pulmonary toxicity after initiation of azathioprine for treatment of interstitial pneumonia in a patient with rheumatoid arthritis.
    The Journal of rheumatology, 2012, Volume: 39, Issue:5

    Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Dyspnea; Humans; Lung Diseases, Int

2012
Chronic inflammatory demyelinating polyneuropathy and respiratory failure.
    Journal of neurology, 2005, Volume: 252, Issue:10

    Topics: Aged; Azathioprine; Biopsy; Coma; Cyclophosphamide; Electromyography; Female; Follow-Up Studies; Hum

2005
Acute exacerbation (acute lung injury of unknown cause) in UIP and other forms of fibrotic interstitial pneumonias.
    The American journal of surgical pathology, 2007, Volume: 31, Issue:2

    Topics: Adult; Aged; Alveolitis, Extrinsic Allergic; Azathioprine; Biopsy; Cyclophosphamide; Disease Progres

2007
Acute exacerbation (acute lung injury of unknown cause) in UIP and other forms of fibrotic interstitial pneumonias.
    The American journal of surgical pathology, 2007, Volume: 31, Issue:2

    Topics: Adult; Aged; Alveolitis, Extrinsic Allergic; Azathioprine; Biopsy; Cyclophosphamide; Disease Progres

2007
Acute exacerbation (acute lung injury of unknown cause) in UIP and other forms of fibrotic interstitial pneumonias.
    The American journal of surgical pathology, 2007, Volume: 31, Issue:2

    Topics: Adult; Aged; Alveolitis, Extrinsic Allergic; Azathioprine; Biopsy; Cyclophosphamide; Disease Progres

2007
Acute exacerbation (acute lung injury of unknown cause) in UIP and other forms of fibrotic interstitial pneumonias.
    The American journal of surgical pathology, 2007, Volume: 31, Issue:2

    Topics: Adult; Aged; Alveolitis, Extrinsic Allergic; Azathioprine; Biopsy; Cyclophosphamide; Disease Progres

2007
[Fulminant, fatal respiratory insufficiency in long-term immunosuppression after kidney transplantation].
    Der Radiologe, 1995, Volume: 35, Issue:3

    Topics: Adult; Azathioprine; Fatal Outcome; Female; Humans; Immunologic Deficiency Syndromes; Kidney Transpl

1995
[Myasthenic crisis caused by azathioprine-induced fever].
    Der Nervenarzt, 1997, Volume: 68, Issue:4

    Topics: Aged; Azathioprine; Critical Care; Drug Hypersensitivity; Drug Therapy, Combination; Fever; Humans;

1997
Recurrence of hepatitis B after single lung transplantation.
    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 1999, Volume: 18, Issue:12

    Topics: Adult; Azathioprine; Female; Hepatitis B Antibodies; Hepatitis B, Chronic; Humans; Immunosuppression

1999
Interstitial pneumonitis complicating rheumatoid arthritis. Sustained remission with azathioprine therapy.
    Chest, 1977, Volume: 72, Issue:4

    Topics: Arthritis, Rheumatoid; Azathioprine; Female; Humans; Middle Aged; Pneumonia; Pulmonary Fibrosis; Res

1977
Myasthenia gravis and steroid-induced myopathy of the respiratory muscles.
    Intensive care medicine, 1992, Volume: 18, Issue:7

    Topics: Adrenal Cortex Hormones; Adult; Atrophy; Azathioprine; Electromyography; Female; Humans; Lung Volume

1992
Unsuspected myasthenia gravis presenting as respiratory failure.
    Thorax, 1990, Volume: 45, Issue:5

    Topics: Azathioprine; Humans; Male; Middle Aged; Myasthenia Gravis; Prednisolone; Respiratory Insufficiency

1990
[Results following canine pulmonary transplantation (author's transl)].
    Thoraxchirurgie, vaskulare Chirurgie, 1974, Volume: 22, Issue:4

    Topics: Animals; Azathioprine; Bronchospirometry; Dogs; Graft Rejection; Hemodynamics; Immunosuppression The

1974
Pattern recognition in medicine--a place for the use of principal component analysis and factor analysis.
    Australian and New Zealand journal of medicine, 1974, Volume: 4, Issue:5

    Topics: Azathioprine; Body Height; Body Weight; Child; Computers; Cyclophosphamide; Diagnosis, Differential;

1974
Acute fulminant Wegener granulomatosis. Therapy with immunosuppression, hemodialysis, and renal transplantation.
    Archives of internal medicine, 1974, Volume: 134, Issue:1

    Topics: Acute Disease; Adult; Antilymphocyte Serum; Azathioprine; Fluorescent Antibody Technique; Granulomat

1974
Wegener's granulomatosis. Treatment with heparin in addition to azathioprine and corticosteroids.
    Nephron, 1972, Volume: 9, Issue:4

    Topics: Acute Kidney Injury; Azathioprine; Biopsy; Granulomatosis with Polyangiitis; Heparin; Humans; Kidney

1972
[Nitrofurantoin-induced chronic pulmonary fibrosis (author's transl)].
    Deutsche medizinische Wochenschrift (1946), 1973, Oct-05, Volume: 98, Issue:40

    Topics: Adrenal Cortex Hormones; Aged; Azathioprine; Chronic Disease; Fever; Humans; Male; Nitrofurantoin; P

1973