azathioprine has been researched along with Precursor Cell Lymphoblastic Leukemia-Lymphoma in 19 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Precursor Cell Lymphoblastic Leukemia-Lymphoma: A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this report, we describe the safe and effective use of trametinib combined with dasatinib in a patient with acute lymphoblastic leukemia (ALL)." | 1.62 | Successful use of trametinib and dasatinib combined with chemotherapy in the treatment of Ph-positive B-cell acute lymphoblastic leukemia: A case report. ( Hu, BF; Shen, SH; Wang, GL; Wang, J, 2021) |
| "Haematological involvement of systemic lupus erythematosus (SLE) - which ranges from the well-described haemolytic anaemia to macrophage activation syndrome - has a large impact on both morbidity and mortality." | 1.38 | Acute lymphoblastic leukaemia in a child with systemic lupus erythematosus. ( Besbas, N; Bilginer, Y; Bulus, D; Cetin, M; Gokce, M; Gumruk, F, 2012) |
| "The renal biopsy showed type I membranoproliferative glomerulonephritis." | 1.36 | Membranoproliferative glomerulonephritis following allogeneic hematopoietic stem cell transplantation. ( Chang, YS; Chung, S; Kim, B; Kim, JY; Lee, MY; Park, CW, 2010) |
| "A 26-year-old male with acute lymphoblastic leukemia (ALL) in its second complete remission received an unrelated bone marrow transplantation (UBMT) following cyclophosphamide plus total body irradiation conditioning." | 1.31 | A successful second unrelated BMT (UBMT) from a different unrelated donor to treat ALL that relapsed after the initial UBMT. ( Nakaseko, C; Nishimura, M; Saito, Y; Uehara, T; Yokota, A, 2002) |
| "The use of azathioprine in ulcerative colitis is unclear." | 1.28 | The role of azathioprine in the management of ulcerative colitis. ( Axon, AT; Burke, DA; Foster, PN; Johnston, D; Lobo, AJ, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (21.05) | 18.2507 |
| 2000's | 7 (36.84) | 29.6817 |
| 2010's | 4 (21.05) | 24.3611 |
| 2020's | 4 (21.05) | 2.80 |
| Authors | Studies |
|---|---|
| Marinaki, AM | 1 |
| Arenas-Hernandez, M | 1 |
| Franca, R | 1 |
| Stocco, G | 1 |
| Favretto, D | 1 |
| Giurici, N | 1 |
| Del Rizzo, I | 1 |
| Locatelli, F | 1 |
| Vinti, L | 1 |
| Biondi, A | 1 |
| Colombini, A | 1 |
| Fagioli, F | 1 |
| Barisone, E | 1 |
| Pelin, M | 1 |
| Martellossi, S | 1 |
| Ventura, A | 1 |
| Decorti, G | 2 |
| Rabusin, M | 1 |
| Pavlovic, S | 1 |
| Kotur, N | 1 |
| Stankovic, B | 1 |
| Gasic, V | 1 |
| Lucafo, M | 1 |
| Zukic, B | 1 |
| Wang, J | 1 |
| Shen, SH | 1 |
| Hu, BF | 1 |
| Wang, GL | 1 |
| Hawwa, AF | 1 |
| Millership, JS | 1 |
| Collier, PS | 1 |
| Vandenbroeck, K | 1 |
| McCarthy, A | 1 |
| Dempsey, S | 1 |
| Cairns, C | 1 |
| Collins, J | 1 |
| Rodgers, C | 1 |
| McElnay, JC | 1 |
| Cesarini, M | 1 |
| Vernia, P | 1 |
| Angelucci, E | 1 |
| Kim, JY | 1 |
| Lee, MY | 1 |
| Kim, B | 1 |
| Park, CW | 1 |
| Chang, YS | 1 |
| Chung, S | 1 |
| Gokce, M | 1 |
| Bulus, D | 1 |
| Bilginer, Y | 1 |
| Gumruk, F | 1 |
| Besbas, N | 1 |
| Cetin, M | 1 |
| Vikingsson, S | 1 |
| Almer, S | 2 |
| Peterson, C | 2 |
| Carlsson, B | 1 |
| Josefsson, M | 1 |
| Uehara, T | 1 |
| Nakaseko, C | 1 |
| Yokota, A | 1 |
| Saito, Y | 1 |
| Nishimura, M | 1 |
| Marshall, E | 1 |
| Coulthard, SA | 2 |
| Matheson, EC | 1 |
| Hall, AG | 2 |
| Hogarth, LA | 1 |
| Johnson, F | 1 |
| Hunt, S | 1 |
| Sergeev, PV | 1 |
| Dukhanin, AS | 1 |
| Stankevich, LI | 1 |
| Erina, TA | 1 |
| Bulaeva, NN | 1 |
| Semeĭkin, AV | 1 |
| Aarbakke, J | 1 |
| Janka-Schaub, G | 1 |
| Elion, GB | 1 |
| Bergan, S | 1 |
| Norge, O | 1 |
| Rabello, C | 1 |
| Robson, J | 1 |
| Howell, C | 1 |
| Minto, L | 1 |
| Middleton, PG | 1 |
| Gandhi, MK | 1 |
| Jackson, G | 1 |
| McLelland, J | 1 |
| O'Brien, H | 1 |
| Smith, S | 1 |
| Reid, MM | 1 |
| Pearson, AD | 1 |
| Pettersson, B | 1 |
| Albertioni, F | 1 |
| Söderhäll, S | 1 |
| Lobo, AJ | 1 |
| Foster, PN | 1 |
| Burke, DA | 1 |
| Johnston, D | 1 |
| Axon, AT | 1 |
3 reviews available for azathioprine and Precursor Cell Lymphoblastic Leukemia-Lymphoma
| Article | Year |
|---|---|
Reducing risk in thiopurine therapy.
Topics: Azathioprine; Drug Hypersensitivity; Erythrocytes; Female; Genotype; Humans; Male; Mercaptopurine; M | 2020 |
Clinical Application of Thiopurine Pharmacogenomics in Pediatrics.
Topics: Azathioprine; Genetic Markers; Humans; Inflammatory Bowel Diseases; Pediatrics; Pharmacogenetics; Pr | 2020 |
The clinical impact of thiopurine methyltransferase polymorphisms on thiopurine treatment.
Topics: Alanine; Antimetabolites, Antineoplastic; Azathioprine; DNA; DNA Methylation; Drug Resistance, Neopl | 2004 |
2 trials available for azathioprine and Precursor Cell Lymphoblastic Leukemia-Lymphoma
| Article | Year |
|---|---|
PACSIN2 rs2413739 influence on thiopurine pharmacokinetics: validation studies in pediatric patients.
Topics: Adaptor Proteins, Signal Transducing; Adolescent; Adult; Azathioprine; Child; Child, Preschool; Coho | 2020 |
Differences between children and adults in thiopurine methyltransferase activity and metabolite formation during thiopurine therapy: possible role of concomitant methotrexate.
Topics: Adult; Age Factors; Antimetabolites, Antineoplastic; Azathioprine; Child; Drug Therapy, Combination; | 2002 |
14 other studies available for azathioprine and Precursor Cell Lymphoblastic Leukemia-Lymphoma
| Article | Year |
|---|---|
Successful use of trametinib and dasatinib combined with chemotherapy in the treatment of Ph-positive B-cell acute lymphoblastic leukemia: A case report.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Azathioprine; Child; Consolidation Che | 2021 |
Pharmacogenomic studies of the anticancer and immunosuppressive thiopurines mercaptopurine and azathioprine.
Topics: Adolescent; Antimetabolites, Antineoplastic; Azathioprine; Child; Child, Preschool; Female; Gene Fre | 2008 |
Acute lymphoid leukemia in a Crohn's disease patient during treatment with adalimumab after a prolonged treatment with azathioprine and steroids.
Topics: Adalimumab; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Aza | 2010 |
Membranoproliferative glomerulonephritis following allogeneic hematopoietic stem cell transplantation.
Topics: Adult; Azathioprine; Glomerulonephritis, Membranoproliferative; Graft vs Host Disease; Hematopoietic | 2010 |
Acute lymphoblastic leukaemia in a child with systemic lupus erythematosus.
Topics: Antimetabolites; Azathioprine; Child; Fatal Outcome; Female; Humans; Lupus Erythematosus, Systemic; | 2012 |
Monitoring of thiopurine metabolites - a high-performance liquid chromatography method for clinical use.
Topics: Adult; Analytic Sample Preparation Methods; Antimetabolites, Antineoplastic; Azathioprine; Biotransf | 2013 |
A successful second unrelated BMT (UBMT) from a different unrelated donor to treat ALL that relapsed after the initial UBMT.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Azathioprine; Bone Marrow Trans | 2002 |
Preventing toxicity with a gene test.
Topics: Advisory Committees; Azathioprine; Child; Drug Labeling; Drug Utilization; Genetic Testing; Humans; | 2003 |
Recurrent lymphoma in a cardiac allograft recipient.
Topics: Azathioprine; Cyclosporine; Follow-Up Studies; Graft Rejection; Heart Transplantation; Humans; Lung | 1994 |
[Comparative study of the interaction of purine antagonists with adenosine receptors of bone marrow lymphocytes and lymphoblasts].
Topics: Azathioprine; Bone Marrow; Bone Marrow Cells; Humans; Lymphocytes; Mercaptopurine; Precursor Cell Ly | 1993 |
Thiopurine biology and pharmacology.
Topics: Animals; Antimetabolites, Antineoplastic; Azathioprine; Cloning, Molecular; Genotype; Humans; Immuno | 1997 |
[Better therapeutic potential for azathioprine and mercaptopurine].
Topics: Antimetabolites, Antineoplastic; Azathioprine; Child; Genotype; Humans; Mercaptopurine; Methyltransf | 2000 |
A comparison of molecular and enzyme-based assays for the detection of thiopurine methyltransferase mutations.
Topics: Adolescent; Adult; Azathioprine; Blood Donors; Child; Child, Preschool; DNA Mutational Analysis; Fem | 2000 |
The role of azathioprine in the management of ulcerative colitis.
Topics: Adult; Azathioprine; Colitis, Ulcerative; Female; Humans; Leukopenia; Lymphoma, Non-Hodgkin; Male; M | 1990 |