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azathioprine and Pemphigoid, Benign Mucous Membrane

azathioprine has been researched along with Pemphigoid, Benign Mucous Membrane in 24 studies

Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.

Pemphigoid, Benign Mucous Membrane: A chronic blistering disease with predilection for mucous membranes and less frequently the skin, and with a tendency to scarring. It is sometimes called ocular pemphigoid because of conjunctival mucous membrane involvement.

Research Excerpts

ExcerptRelevanceReference
"Azathioprine was moderately effective as a single corticosteroid-sparing immunosuppressive agent in terms of control of inflammation and corticosteroid-sparing benefits, but required several months to achieve treatment goals; it seems especially useful for patients with intermediate uveitis."3.75Azathioprine for ocular inflammatory diseases. ( Foster, CS; Jabs, DA; Kempen, JH; Levy-Clarke, GA; Liesegang, TL; Newcomb, CW; Nussenblatt, RB; Pasadhika, S; Pujari, SS; Rosenbaum, JT; Suhler, EB; Thorne, JE, 2009)
"Ocular cicatricial pemphigoid (OCP) is a rare autoimmune disease with heterogenous clinical manifestations."1.51Ocular Cicatricial Pemphigoid: Camouflaged as Persistent Conjunctivitis. ( Erum, U; Mughal, JU; Muhammad, AJ, 2019)
"Dapsone was useful in mild cases, with frequent adverse effects."1.38[Systemic treatment of ocular cicatricial pemphigoid]. ( Devoto, MH; Fernández Romero, DS; Georgiett, D; Juri, MC; Malbrán, A; Zárate, JO, 2012)
"Dapsone was the most commonly used drug (51 patients), followed by methotrexate (24 patients), azathioprine (23 patients), and cyclophosphamide (15 patients); prednisone, always given as adjunctive treatment, was used in 17 patients."1.31The effect of treatment and its related side effects in patients with severe ocular cicatricial pemphigoid. ( Ahmed, AR; Baltatzis, S; Foster, CS; Miserocchi, E; Roque, MR, 2002)
"Nine patients (11 eyes) with ocular cicatricial pemphigoid were treated with systemic azathioprine and a syngeneic nasal mucosa transplant from the inferior turbinate."1.29[Syngeneic transplantation of nasal mucosa and azathioprine medication for therapy of cicatricial ocular mucous membrane pemphigoid. Study of 9 patients with 11 eyes]. ( Bialasiewicz, AA; Busse, H; Förster, W; Grewe, S; Hüttenbrink, KB; Radig, H, 1994)
"The diagnosis of cicatricial pemphigoid requires characteristic lesions and histopathologic evidence of immunoglobulin deposition along the basement membrane, as well as a high index of suspicion."1.29Management of airway obstruction in cicatricial pemphigoid. ( Goodman, ML; Lazor, JB; Mackool, BT; Montgomery, WW; Varvares, MA, 1996)
"Ocular cicatricial pemphigoid (OCP) is a chronic, progressive, autoimmune disease that scars mucus membranes and may lead to blindness."1.28Remission and recurrence after withdrawal of therapy for ocular cicatricial pemphigoid. ( Foster, CS; Neumann, R; Tauber, J, 1991)
"We found that untreated ocular cicatricial pemphigoid has a variable course and does not necessarily progress."1.27Immunosuppressive therapy in ocular cicatricial pemphigoid. ( Brown, SI; Mondino, BJ, 1983)
"1."1.26[Disseminated cicatricial pemphigoid]. ( Braun-Falco, O; Ponce, E; Wolff, HH, 1981)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19903 (12.50)18.7374
1990's7 (29.17)18.2507
2000's7 (29.17)29.6817
2010's5 (20.83)24.3611
2020's2 (8.33)2.80

Authors

AuthorsStudies
Yaïci, R1
Roth, M1
Juergens, L1
Nawaiseh, SA1
Burkhard, D1
Besgen, V1
Fuest, M1
Girbardt, C1
Hampel, U1
Heichel, J1
Heiligenhaus, A1
Herwig-Carl, MC1
Kakkassery, V1
Kontopoulou, K1
Löffler, KU1
Maier, PC1
Nölle, B1
Pach, J1
Paul, S1
Pleyer, U1
Pöllmann, M1
Saeger, M1
Schmidt, E1
Siebelmann, S1
Sokolenko, E1
Strudel, L1
Stübiger, N1
Tarhan, M1
Theuersbacher, J1
van Oterendorp, C1
Walker, M1
Wiecha, C1
Wykrota, AA1
Geerling, G1
Smichowski, AM1
Caputo, VD1
Romeo, C1
Rivero, E1
Morales, NS1
Casado, G1
Mughal, JU1
Muhammad, AJ1
Erum, U1
Gaudio, PA1
Sinard, J1
Shield, DR1
Huang, JJ1
King, BA1
Liu, A1
Yang, DJ1
Hsu, S1
Tauber, J3
Pasadhika, S1
Kempen, JH1
Newcomb, CW1
Liesegang, TL1
Pujari, SS1
Rosenbaum, JT1
Thorne, JE1
Foster, CS4
Jabs, DA1
Levy-Clarke, GA1
Nussenblatt, RB1
Suhler, EB1
Kennedy, JS1
Devillez, RL1
Henning, JS1
McGinness, JL1
Spicknall, KE1
Mutasim, DF1
Juri, MC1
Fernández Romero, DS1
Devoto, MH1
Georgiett, D1
Zárate, JO1
Malbrán, A1
Saw, VP1
Dart, JK1
Rauz, S1
Ramsay, A1
Bunce, C1
Xing, W1
Maddison, PG1
Phillips, M1
Mondino, BJ1
Brown, SI1
Braun-Falco, O1
Wolff, HH1
Ponce, E1
Bialasiewicz, AA1
Förster, W1
Radig, H1
Hüttenbrink, KB1
Grewe, S1
Busse, H1
Warren, SD1
Lesher, JL1
Lazor, JB1
Varvares, MA1
Montgomery, WW1
Goodman, ML1
Mackool, BT1
Singer, NG1
McCune, WJ1
Messmer, EM1
Hintschich, CR1
Partscht, K1
Messer, G1
Kampik, A1
Epstein, JB1
Gorsky, M1
Epstein, MS1
Nantel, S1
Miserocchi, E1
Baltatzis, S1
Roque, MR1
Ahmed, AR1
Lamey, PJ1
Rees, TD1
Binnie, WH1
Rankin, KV1
Neumann, R1
Sainz de la Maza, M1
Pawlofsky, C1
Simon, M1
Fartasch, M1
Keller, J1

Reviews

1 review available for azathioprine and Pemphigoid, Benign Mucous Membrane

ArticleYear
Update on immunosuppressive therapy.
    Current opinion in rheumatology, 1998, Volume: 10, Issue:3

    Topics: Adult; Arthritis, Juvenile; Azathioprine; Behcet Syndrome; Child; Cladribine; Cyclophosphamide; Cycl

1998

Other Studies

23 other studies available for azathioprine and Pemphigoid, Benign Mucous Membrane

ArticleYear
On the Current Care Situation and Treatment of Ocular Mucous Membrane Pemphigoid in Germany.
    Klinische Monatsblatter fur Augenheilkunde, 2023, Volume: 240, Issue:9

    Topics: Azathioprine; Humans; Immunosuppressive Agents; Mucous Membrane; Pemphigoid, Benign Mucous Membrane;

2023
Ocular cicatricial pemphigoid: Methotrexate as an initial treatment?
    Reumatologia clinica, 2022, Volume: 18, Issue:1

    Topics: Azathioprine; Cyclophosphamide; Humans; Immunosuppressive Agents; Methotrexate; Pemphigoid, Benign M

2022
Ocular Cicatricial Pemphigoid: Camouflaged as Persistent Conjunctivitis.
    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2019, Volume: 29, Issue:6

    Topics: Autoimmune Diseases; Azathioprine; Conjunctiva; Conjunctivitis; Cornea; Corneal Perforation; Cycloph

2019
Repeat Conjunctival Biopsy after Immunomodulatory Therapy for Ocular Mucous Membrane Pemphigoid.
    Ocular immunology and inflammation, 2018, Volume: 26, Issue:1

    Topics: Aged; Aged, 80 and over; Azathioprine; Biopsy; Conjunctiva; Conjunctival Diseases; Cyclophosphamide;

2018
A quick and simple serum test to differentiate bullous pemphigoid, epidermolysis bullosa acquisita, and anti-epiligrin cicatricial pemphigoid.
    Dermatology online journal, 2008, Jul-15, Volume: 14, Issue:7

    Topics: Aged; Azathioprine; Cell Adhesion Molecules; Complement C3; Diagnosis, Differential; Drug Therapy, C

2008
Ocular cicatricial pemphigoid.
    Ophthalmology, 2008, Volume: 115, Issue:9

    Topics: Azathioprine; Conjunctival Diseases; Cyclophosphamide; Dapsone; Drug Therapy, Combination; Humans; I

2008
Azathioprine for ocular inflammatory diseases.
    American journal of ophthalmology, 2009, Volume: 148, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Azathioprine; Child; Female; Follow-Up Studies; Humans;

2009
Recalcitrant cicatricial pemphigoid treated with the anti-TNF-alpha agent etanercept.
    Journal of drugs in dermatology : JDD, 2010, Volume: 9, Issue:1

    Topics: Administration, Topical; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Azathiop

2010
Azathioprine-induced EBV-positive mucocutaneous ulcer.
    Journal of cutaneous pathology, 2012, Volume: 39, Issue:3

    Topics: Aged; Antigens, CD20; Antimetabolites, Antineoplastic; Azathioprine; B-Lymphocytes; Epstein-Barr Vir

2012
[Systemic treatment of ocular cicatricial pemphigoid].
    Medicina, 2012, Volume: 72, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Autoimmune Diseases; Azathioprine; Dapsone; Delayed Diagnosis; Femal

2012
Immunosuppressive therapy for ocular mucous membrane pemphigoid strategies and outcomes.
    Ophthalmology, 2008, Volume: 115, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Azathioprine; Conjunctival Diseases; Cyclophosphamide; D

2008
Immunosuppressive therapy in ocular cicatricial pemphigoid.
    American journal of ophthalmology, 1983, Volume: 96, Issue:4

    Topics: Aged; Azathioprine; Cyclophosphamide; Eye Diseases; Female; Humans; Immunosuppressive Agents; Male;

1983
[Disseminated cicatricial pemphigoid].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1981, Volume: 32, Issue:5

    Topics: Aged; Azathioprine; Basement Membrane; Complement C3; Humans; Immunoglobulin M; Male; Pemphigoid, Be

1981
[Syngeneic transplantation of nasal mucosa and azathioprine medication for therapy of cicatricial ocular mucous membrane pemphigoid. Study of 9 patients with 11 eyes].
    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 1994, Volume: 91, Issue:2

    Topics: Aged; Aged, 80 and over; Azathioprine; Combined Modality Therapy; Conjunctivitis; Female; Follow-Up

1994
Cicatricial pemphigoid.
    Southern medical journal, 1993, Volume: 86, Issue:4

    Topics: Aged; Azathioprine; Dapsone; Fluorescent Antibody Technique; Humans; Male; Mouth Mucosa; Pemphigoid,

1993
Management of airway obstruction in cicatricial pemphigoid.
    The Laryngoscope, 1996, Volume: 106, Issue:8

    Topics: Adult; Airway Obstruction; Anti-Inflammatory Agents; Azathioprine; Chronic Disease; Diagnosis, Diffe

1996
[Ocular cicatricial pemphigoid. Retrospective analysis of risk factors and complications].
    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 2000, Volume: 97, Issue:2

    Topics: Adrenal Cortex Hormones; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Azathiopr

2000
Topical azathioprine in the treatment of immune-mediated chronic oral inflammatory conditions: a series of cases.
    Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 2001, Volume: 91, Issue:1

    Topics: Adult; Autoimmune Diseases; Azathioprine; Chronic Disease; Erythema; Female; Gels; Graft vs Host Dis

2001
The effect of treatment and its related side effects in patients with severe ocular cicatricial pemphigoid.
    Ophthalmology, 2002, Volume: 109, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Autoimmune Diseases; Azathi

2002
Mucous membrane pemphigoid. Treatment experience at two institutions.
    Oral surgery, oral medicine, and oral pathology, 1992, Volume: 74, Issue:1

    Topics: Administration, Topical; Adolescent; Adult; Aged; Anti-Inflammatory Agents; Azathioprine; Cyclophosp

1992
Remission and recurrence after withdrawal of therapy for ocular cicatricial pemphigoid.
    Ophthalmology, 1991, Volume: 98, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Azathioprine; Cyclophosphamide; Dapsone; Female; Follow-Up Studies;

1991
Systemic chemotherapy for ocular cicatricial pemphigoid.
    Cornea, 1991, Volume: 10, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Autoimmune Diseases; Azathioprine; Conjunctivitis; Cyclophosphamide;

1991
Disseminated cicatricial pemphigoid.
    Dermatologica, 1985, Volume: 171, Issue:4

    Topics: Azathioprine; Drug Therapy, Combination; Humans; Male; Middle Aged; Pemphigoid, Benign Mucous Membra

1985