Page last updated: 2024-10-23

azathioprine and Paraproteinemias

azathioprine has been researched along with Paraproteinemias in 14 studies

Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.

Paraproteinemias: A group of related diseases characterized by an unbalanced or disproportionate proliferation of immunoglobulin-producing cells, usually from a single clone. These cells frequently secrete a structurally homogeneous immunoglobulin (M-component) and/or an abnormal immunoglobulin.

Research Excerpts

ExcerptRelevanceReference
"Eighteen of them also had monoclonal gammopathy of undetermined significance (MGUS)."2.69Chronic inflammatory demyelinating polyradiculoneuropathy: long-term course and treatment of 60 patients. ( Ciano, C; Fallica, E; Mariotti, C; Pareyson, D; Sghirlanzoni, A; Solari, A, 2000)
"Colchicine has been stopped while the azathioprine and prednisolone doses are being reduced."1.36Dramatic response to IL1-RA treatment in longstanding multidrug resistant Schnitzler's syndrome: a case report and literature review. ( Besada, E; Nossent, H, 2010)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19908 (57.14)18.7374
1990's3 (21.43)18.2507
2000's2 (14.29)29.6817
2010's1 (7.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Besada, E1
Nossent, H1
Rubin, L1
Urowitz, MB1
Pruzanski, W1
Evans, TW1
Nicholls, AJ1
Shortland, JR1
Ward, AM1
Brown, CB1
Dosa, S1
Cairns, SA1
Mallick, NP1
Lawler, W1
Williams, G1
Fontana, A1
Doll, B1
Joller, H1
Kathol, RC1
Hamilton, HE1
Nickerson, PW1
Rush, DN1
Jeffery, JR1
Pochinco, D1
McKenna, RM1
Passweg, J1
Thiel, G1
Bock, HA1
Pham, H1
Lemoine, A1
Salvucci, M1
Azoulay, D1
Frenoy, N1
Samuel, D1
Reynès, M1
Bismuth, H1
Debuire, B1
Sghirlanzoni, A1
Solari, A1
Ciano, C1
Mariotti, C1
Fallica, E1
Pareyson, D1
Strobel, ES1
Fritschka, E1
Schmitt-Gräff, A1
Peter, HH1
Ruzicka, T1
Goerz, G1
Hartmann, S1
Hartmann, G1
Duckert, F1
Kiprov, DD1
Miller, RG1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Ilaris (Canakinumab) in the Schnitzler Syndrome. A Case Series.[NCT01245127]Phase 21 participants (Actual)Interventional2011-05-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

2 trials available for azathioprine and Paraproteinemias

ArticleYear
Occurrence of gammopathies and lymphoproliferative disorders in liver transplant recipients randomized to tacrolimus (FK506)- or cyclosporine-based immunosuppression.
    Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 1998, Volume: 4, Issue:2

    Topics: Adrenal Cortex Hormones; Adult; Azathioprine; Cyclosporine; Female; Humans; Liver Transplantation; L

1998
Chronic inflammatory demyelinating polyradiculoneuropathy: long-term course and treatment of 60 patients.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2000, Volume: 21, Issue:1

    Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Azathioprine; Child; Cyclophosphamide; Electrophy

2000

Other Studies

12 other studies available for azathioprine and Paraproteinemias

ArticleYear
Dramatic response to IL1-RA treatment in longstanding multidrug resistant Schnitzler's syndrome: a case report and literature review.
    Clinical rheumatology, 2010, Volume: 29, Issue:5

    Topics: Adult; Aged; Azathioprine; Blood Sedimentation; C-Reactive Protein; Colchicine; Female; Humans; Immu

2010
Systemic lupus erythematosus with paraproteinemia.
    Arthritis and rheumatism, 1984, Volume: 27, Issue:6

    Topics: Adult; Aged; Antibodies, Antinuclear; Azathioprine; Female; Glomerulonephritis; Glycoproteins; HLA A

1984
Acute renal failure in essential mixed cryoglobulinemia: precipitation and reversal by plasma exchange.
    Clinical nephrology, 1984, Volume: 21, Issue:5

    Topics: Acute Kidney Injury; Adult; Azathioprine; Biopsy; Cryoglobulinemia; Humans; Kidney; Male; Paraprotei

1984
Relapsing Henoch-Schönlein syndrome with renal involvement in a patient with an IgA monoclonal gammopathy. A study of the results of immunosuppressant and cytotoxic therapy.
    Nephron, 1980, Volume: 26, Issue:3

    Topics: Adult; Antineoplastic Agents; Azathioprine; Bence Jones Protein; Biopsy; Female; Humans; Hypergammag

1980
[IgG-IgM cryoglobulinemia with a purpura-arthralgia-nephritis syndrome].
    Schweizerische medizinische Wochenschrift, 1982, Jan-02, Volume: 112, Issue:1

    Topics: Adult; Azathioprine; Blood Protein Disorders; Cryoglobulinemia; Cyclophosphamide; Female; Humans; Im

1982
Azathioprine-induced plasmacytosis.
    JAMA, 1981, Nov-13, Volume: 246, Issue:19

    Topics: Arthritis, Rheumatoid; Azathioprine; Bone Marrow Cells; Diagnosis, Differential; Female; Humans; Mid

1981
High serum levels of interleukin-6 in renal transplant recipients with monoclonal gammopathies.
    Transplantation, 1994, Aug-15, Volume: 58, Issue:3

    Topics: Adult; Aged; Azathioprine; Cyclosporine; Female; Follow-Up Studies; Graft Rejection; Humans; Interle

1994
Monoclonal gammopathy after intense induction immunosuppression in renal transplant patients.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1996, Volume: 11, Issue:12

    Topics: Antilymphocyte Serum; Azathioprine; Cyclosporine; Humans; Immunoelectrophoresis; Immunosuppression T

1996
An unusual case of systemic lupus erythematosus, lupus nephritis, and transient monoclonal gammopathy.
    Rheumatology international, 2000, Volume: 19, Issue:6

    Topics: Adult; Antirheumatic Agents; Azathioprine; Cyclophosphamide; Female; Humans; Immunosuppressive Agent

2000
[Observations in Hallopeaus's vegetative pyoderma].
    Zeitschrift fur Hautkrankheiten, 1979, Jan-01, Volume: 54, Issue:1

    Topics: Aged; Azathioprine; Female; Glucocorticoids; Humans; Immunoglobulin A; Paraproteinemias; Pyoderma; S

1979
[Severe coagulopathy due to inhibitors of several clotting factors in IgM paraproteinaemia (author's transl)].
    Deutsche medizinische Wochenschrift (1946), 1976, Feb-20, Volume: 101, Issue:8

    Topics: Azathioprine; Factor V; Factor VII; Hemorrhagic Disorders; Humans; Immunoglobulin M; Male; Middle Ag

1976
Paraproteinemia associated with demyelinating polyneuropathy or myositis: treatment with plasmapheresis and immunosuppressive drugs.
    Artificial organs, 1985, Volume: 9, Issue:1

    Topics: Azathioprine; Cyclophosphamide; Demyelinating Diseases; Female; Humans; Immunosuppressive Agents; Ma

1985