azathioprine has been researched along with Pancytopenia in 56 studies
Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.
Pancytopenia: Deficiency of all three cell elements of the blood, erythrocytes, leukocytes and platelets.
| Excerpt | Relevance | Reference |
|---|---|---|
| " After prednisolone and methotrexate failed to have the desired effect, he was treated with azathioprine, which caused pancytopenia, and manifested as fever with positive blood culture for a coagulase-negative staphylococcus infection." | 8.12 | Azathioprine Induced Pancytopenia in a Patient with Vogt-Koyanagi-Harada Disease: A Case Report. ( Barman, P; Bhattarai, S; Khatri, S; Manandhar, D; Pyakurel, S; Regmi, S; Singh, AK, 2022) |
| "We describe two multiple sclerosis patients who developed pancytopenia following treatment with azathioprine." | 7.73 | Azathioprine myelosuppression in multiple sclerosis: characterizing thiopurine methyltransferase polymorphisms. ( Frohman, EM; Havrdova, E; Levinson, B; Slanar, O, 2006) |
| "Severe pancytopenia due to azathioprine (AZA) toxicity in patients with autoimmune diseases is not uncommon." | 7.69 | Azathioprine-induced severe pancytopenia due to a homozygous two-point mutation of the thiopurine methyltransferase gene in a patient with juvenile HLA-B27-associated spondylarthritis. ( Haas, JP; Leipold, G; Oellerich, M; Schütz, E, 1997) |
| "A patient with systemic lupus erythematosus (SLE) developed pancytopenia when azathioprine (first 2." | 7.68 | Pancytopenia in systemic lupus erythematosus related to azathioprine. ( Nossent, JC; Swaak, AJ, 1990) |
| " All inflammatory bowel disease symptoms resolved after treatment with azathioprine, which was associated with the development of pancytopenia." | 7.67 | Ulcerative colitis: prolonged remission following azathioprine-induced pancytopenia. ( Axon, AT; Burke, DA; Dixon, MF, 1989) |
| "Two patients with rheumatoid arthritis developed pancytopenia during treatment with azathioprine 100 mg daily." | 7.67 | Pancytopenia related to azathioprine in rheumatoid arthritis. ( Boerbooms, AM; Jeurissen, ME; van de Putte, LB, 1988) |
| "Chlorambucil is useful in patients with rheumatoid arthritis (RA) refractory to other agents but there is concern about the risk of haematological malignancy with this agent." | 7.67 | The oncogenicity of chlorambucil in rheumatoid arthritis. ( Browne, CD; Champion, GD; Cohen, ML; Day, RO; Graham, S; Patapanian, H; Sambrook, PN, 1988) |
| "Azathioprine is an immunosuppressive drug that has shown effectiveness in inflammatory bowel disease treatment." | 5.43 | [Azathioprine-induced pancytopenia: case series]. ( López Campos, M; Martínez de Zabarte Fernández, JM; Martínez Faci, C; Rodríguez-Vigil Iturrate, C; Ros Arnal, I; Sorribes Estorch, J, 2016) |
| "Azathioprine can cause severe myelosuppression." | 5.29 | Azathioprine-induced myelosuppression due to thiopurine methyltransferase deficiency in a patient with autoimmune hepatitis. ( Ben Ari, Z; Burroughs, AK; Lennard, L; Mehta, A, 1995) |
| " After prednisolone and methotrexate failed to have the desired effect, he was treated with azathioprine, which caused pancytopenia, and manifested as fever with positive blood culture for a coagulase-negative staphylococcus infection." | 4.12 | Azathioprine Induced Pancytopenia in a Patient with Vogt-Koyanagi-Harada Disease: A Case Report. ( Barman, P; Bhattarai, S; Khatri, S; Manandhar, D; Pyakurel, S; Regmi, S; Singh, AK, 2022) |
| "A 50-year-old man who had received a simultaneous pancreas and kidney transplant 9 years earlier developed pancytopenia 3 weeks after starting azathioprine therapy to treat worsening proteinuria suspected to be caused by sirolimus." | 3.77 | Azathioprine-related myelosuppression in a patient homozygous for TPMT*3A. ( Budhiraja, P; Popovtzer, M, 2011) |
| "A dog being treated with immunosuppressive doses of prednisone and azathioprine for pancytopenia of unknown origin, developed, over a 2-week period, multiple erythematous nodular lesions in the skin including footpads." | 3.76 | Bacillary angiomatosis in an immunosuppressed dog. ( Best, SJ; Breitschwerdt, EB; Maggi, RG; Varanat, M; Yager, JA; Znajda, N, 2010) |
| "The medical records of eight patients who developed severe pancytopenia following concomitant use of azathioprine and ribavirin were retrospectively reviewed." | 3.74 | Interaction of ribavirin with azathioprine metabolism potentially induces myelosuppression. ( Bigard, MA; Bronowicki, JP; Cadranel, JF; Canva, V; Cortot, A; Gueant, JL; Nousbaum, JB; Oussalah, A; Peyrin-Biroulet, L; Roblin, X; Seddik, M; Sogni, P, 2008) |
| "Pancytopenia was most likely azathioprine-related." | 3.74 | [Nodular regenerative hyperplasia as a side effect of azathioprine in a patient with Crohn's disease]. ( Günther, U; Loddenkemper, C; Preiss, JC; Schumann, M; Siegmund, B; Somasundaram, R; Zeitz, M, 2008) |
| "We describe two multiple sclerosis patients who developed pancytopenia following treatment with azathioprine." | 3.73 | Azathioprine myelosuppression in multiple sclerosis: characterizing thiopurine methyltransferase polymorphisms. ( Frohman, EM; Havrdova, E; Levinson, B; Slanar, O, 2006) |
| "A 49-years-old female with a history of multiple sclerosis and on medication with azathioprine over 5 years amounting to a cumulative dosage of 45 g presented with fatigue and sinus tachycardia." | 3.72 | [Azathioprine-associated myelodysplastic syndrome with cytogenetic aberrations]. ( Kaiser, U; Schlegelberger, B; Wilkens, L; Willerding-Möllmann, S, 2004) |
| " We describe a patient suffering from pancytopenia following a combination therapy of azathioprine and allopurinol because of lupus erythematodes and diabetic nephropathy with hyperuricemia." | 3.72 | [Panzytopenia from combination therapy with azathioprin and allopurinol]. ( Seidel, W, 2004) |
| " Events included eight patients with malignancies, two with pancytopenia taking methotrexate, three with septic arthritis, and two with septicaemias." | 3.71 | Monitoring and assessing the safety of disease-modifying antirheumatic drugs: a West Midlands experience. ( Bevan, J; Homer, D; Jobanputra, P; Maggs, F, 2002) |
| "Azathioprine, a cytostatic and immunosuppressive drug in use for some 30 years, can give rise to life-threatening neutropenia and thrombocytopenia." | 3.70 | [Bone marrow depression after azathioprine. New discoveries on an old drug]. ( Lindstedt, G; Löwhagen, GB, 2000) |
| "To report the price of a drug interaction between azathioprine and allopurinol that resulted in pancytopenia in a patient who had undergone a heart transplant." | 3.69 | Azathioprine and allopurinol: the price of an avoidable drug interaction. ( Hayney, MS; Kennedy, DT; Lake, KD, 1996) |
| "Severe pancytopenia due to azathioprine (AZA) toxicity in patients with autoimmune diseases is not uncommon." | 3.69 | Azathioprine-induced severe pancytopenia due to a homozygous two-point mutation of the thiopurine methyltransferase gene in a patient with juvenile HLA-B27-associated spondylarthritis. ( Haas, JP; Leipold, G; Oellerich, M; Schütz, E, 1997) |
| "A patient with systemic lupus erythematosus (SLE) developed pancytopenia when azathioprine (first 2." | 3.68 | Pancytopenia in systemic lupus erythematosus related to azathioprine. ( Nossent, JC; Swaak, AJ, 1990) |
| " All inflammatory bowel disease symptoms resolved after treatment with azathioprine, which was associated with the development of pancytopenia." | 3.67 | Ulcerative colitis: prolonged remission following azathioprine-induced pancytopenia. ( Axon, AT; Burke, DA; Dixon, MF, 1989) |
| "Two patients with rheumatoid arthritis developed pancytopenia during treatment with azathioprine 100 mg daily." | 3.67 | Pancytopenia related to azathioprine in rheumatoid arthritis. ( Boerbooms, AM; Jeurissen, ME; van de Putte, LB, 1988) |
| "Chlorambucil is useful in patients with rheumatoid arthritis (RA) refractory to other agents but there is concern about the risk of haematological malignancy with this agent." | 3.67 | The oncogenicity of chlorambucil in rheumatoid arthritis. ( Browne, CD; Champion, GD; Cohen, ML; Day, RO; Graham, S; Patapanian, H; Sambrook, PN, 1988) |
| "Myasthenia gravis is an autoimmune disease caused by antibodies to acetylcholine receptors in the post-junctional membrane of the neuromuscular junction." | 1.62 | Visceral leishmaniasis masquerading as drug-induced pancytopenia in myasthenia gravis. ( Azad, S; Bhattacharyya, D; Chattopadhya, D; Dhingra, G; Mohanty, A; Nath, UK, 2021) |
| "The fibroscan data showed significant liver fibrosis (F2-F3)." | 1.43 | Idiopathic portal hypertension regarding thiopurine treatment in patients with inflammatory bowel disease. ( Abreu García, L; Calleja Panero, JL; Calvo Moya, M; González Lama, Y; González Partida, I; Llop Herrera, E; Matallana Royo, V; Suárez Ferrer, C; Vera Mendoza, MI, 2016) |
| "Secondary acute myeloid leukemia is a very rare complication in patients with solid organ transplantation." | 1.42 | [Secondary acute myeloid leukemia in a lung allograft recipient. Report of one case]. ( Guerra, C; Melo, J; Peña, C; Sepúlveda, C, 2015) |
| "Azathioprine therapy was discontinued and she recovered at 3 weeks." | 1.37 | [Azathioprine-associated severe myelosuppression: indication of routine determination of thiopurine S-methyltransferase variant?]. ( Lévesque, H; Marie, I; Ngo, S; Sauvetre, G; Vittecoq, O, 2011) |
| " We describe the case of a young patient with ulcerative colitis, homozygous for TPMT*3A alleles, who suffered fatal azathioprine-induced myelotoxicity after standard dosing with azathioprine." | 1.35 | Fatal myelotoxicity after azathioprine treatment. ( Bortlík, M; Chalupná, P; Krska, Z; Lukás, M; Novotný, A; Slanar, O, 2008) |
| " Experiment 2 was a dose-response study with AZA gavaged daily for 10 days at 40-120 mg/kg." | 1.35 | The haemotoxicity of azathioprine in repeat dose studies in the female CD-1 mouse. ( Chen, CM; Gibson, FM; Marway, HK; McKeag, S; Mifsud, CV; Molyneux, G; Pilling, AM; Turton, JA; Whayman, MJ, 2008) |
| "Among the rare cases of Sweet syndrome associated to a systemic inflammatory response syndrome that have been described there have not been any fatal cases as occurred with our patient." | 1.34 | [Fatal Sweet syndrome associated to chronic idiopathic systemic inflammatory response syndrome]. ( Almagro, M; del Pozo, J; Fonseca, E; Malmierca, NM; Martín, CG; Martínez, W; Yebra-Pimentel, MT, 2007) |
| " Polymerase chain reaction (PCR) tests provide a sensitive, specific means of prospectively identifying these patients before AZA therapy and minimizing toxicity through dosage reduction." | 1.31 | Practical pharmacogenetics: the cost effectiveness of screening for thiopurine s-methyltransferase polymorphisms in patients with rheumatological conditions treated with azathioprine. ( Anis, AH; Esdaile, JM; Marra, CA, 2002) |
| "Azathioprine can cause severe myelosuppression." | 1.29 | Azathioprine-induced myelosuppression due to thiopurine methyltransferase deficiency in a patient with autoimmune hepatitis. ( Ben Ari, Z; Burroughs, AK; Lennard, L; Mehta, A, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (17.86) | 18.7374 |
| 1990's | 8 (14.29) | 18.2507 |
| 2000's | 19 (33.93) | 29.6817 |
| 2010's | 17 (30.36) | 24.3611 |
| 2020's | 2 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Khatri, S | 2 |
| Regmi, S | 1 |
| Pyakurel, S | 1 |
| Bhattarai, S | 1 |
| Barman, P | 1 |
| Manandhar, D | 1 |
| Singh, AK | 1 |
| Nath, UK | 1 |
| Bhattacharyya, D | 1 |
| Chattopadhya, D | 1 |
| Dhingra, G | 1 |
| Azad, S | 1 |
| Mohanty, A | 1 |
| Panda, BK | 1 |
| Umarje, S | 1 |
| Diwan, A | 1 |
| Jensen, CH | 1 |
| Tiu, J | 1 |
| Catalanotti, JS | 1 |
| Shih, YC | 1 |
| Zou, YR | 1 |
| Wang, B | 1 |
| Zheng, J | 1 |
| Pan, M | 1 |
| Peña, C | 1 |
| Sepúlveda, C | 1 |
| Melo, J | 1 |
| Guerra, C | 1 |
| Hsu, WY | 1 |
| Chiou, SS | 1 |
| Liao, YM | 1 |
| Shu, HL | 1 |
| Zeng, YS | 1 |
| Wong, CC | 1 |
| Lin, PC | 1 |
| Suárez Ferrer, C | 1 |
| Llop Herrera, E | 1 |
| Calvo Moya, M | 1 |
| Vera Mendoza, MI | 1 |
| González Partida, I | 1 |
| González Lama, Y | 1 |
| Matallana Royo, V | 1 |
| Calleja Panero, JL | 1 |
| Abreu García, L | 1 |
| Park, SW | 1 |
| Um, SH | 1 |
| Lee, HA | 1 |
| Kim, SH | 1 |
| Sim, Y | 1 |
| Yim, SY | 1 |
| Seo, YS | 1 |
| Ryu, HS | 1 |
| Martínez Faci, C | 1 |
| Ros Arnal, I | 1 |
| Martínez de Zabarte Fernández, JM | 1 |
| Sorribes Estorch, J | 1 |
| López Campos, M | 1 |
| Rodríguez-Vigil Iturrate, C | 1 |
| de Boer, NK | 1 |
| van Bodegraven, AA | 1 |
| de Graaf, P | 1 |
| van der Hulst, RW | 1 |
| Zoetekouw, L | 1 |
| van Kuilenburg, AB | 1 |
| Slanar, O | 2 |
| Chalupná, P | 1 |
| Novotný, A | 1 |
| Bortlík, M | 1 |
| Krska, Z | 1 |
| Lukás, M | 1 |
| Peyrin-Biroulet, L | 1 |
| Cadranel, JF | 1 |
| Nousbaum, JB | 1 |
| Oussalah, A | 1 |
| Seddik, M | 1 |
| Canva, V | 1 |
| Cortot, A | 1 |
| Sogni, P | 1 |
| Gueant, JL | 1 |
| Bigard, MA | 1 |
| Roblin, X | 1 |
| Bronowicki, JP | 1 |
| Schumann, M | 1 |
| Preiss, JC | 1 |
| Loddenkemper, C | 1 |
| Günther, U | 1 |
| Somasundaram, R | 1 |
| Siegmund, B | 1 |
| Zeitz, M | 1 |
| Tabata, R | 1 |
| Tabata, C | 1 |
| Okamoto, T | 1 |
| Omori, K | 1 |
| Terada, M | 1 |
| Nagai, T | 1 |
| Chaparro, M | 1 |
| Trapero-Marugán, M | 1 |
| Moreno-Otero, R | 1 |
| Gisbert, JP | 1 |
| Yager, JA | 1 |
| Best, SJ | 1 |
| Maggi, RG | 1 |
| Varanat, M | 1 |
| Znajda, N | 1 |
| Breitschwerdt, EB | 1 |
| Ngo, S | 1 |
| Sauvetre, G | 1 |
| Vittecoq, O | 1 |
| Lévesque, H | 1 |
| Marie, I | 1 |
| Levine, AB | 1 |
| Erkan, D | 1 |
| Budhiraja, P | 1 |
| Popovtzer, M | 1 |
| Dewit, O | 1 |
| Moreels, T | 1 |
| Baert, F | 1 |
| Peeters, H | 1 |
| Reenaers, C | 1 |
| de Vos, M | 1 |
| Van Hootegem, P | 1 |
| Muls, V | 1 |
| Veereman, G | 1 |
| Mana, F | 1 |
| Van Outryve, M | 1 |
| Holvoet, J | 1 |
| Naegels, S | 1 |
| Piessevaux, H | 1 |
| Horsmans, Y | 1 |
| Gala, JL | 1 |
| Jimeno, A | 1 |
| Morales, E | 1 |
| Peñalver, E | 1 |
| Ladrón de Guevara, S | 1 |
| Kim, JH | 1 |
| Kim, JW | 1 |
| Lim, CY | 1 |
| Park, HM | 1 |
| Weinkove, R | 1 |
| Dickson, M | 1 |
| Eliadou, E | 1 |
| Stace, NH | 1 |
| Goossens, L | 1 |
| Ferguson, P | 1 |
| Jobanputra, P | 1 |
| Maggs, F | 1 |
| Homer, D | 1 |
| Bevan, J | 1 |
| Rosen, R | 1 |
| Integlia, MJ | 1 |
| Bousvaros, A | 1 |
| Marra, CA | 1 |
| Esdaile, JM | 1 |
| Anis, AH | 1 |
| Willerding-Möllmann, S | 1 |
| Wilkens, L | 1 |
| Schlegelberger, B | 1 |
| Kaiser, U | 1 |
| Seidel, W | 1 |
| Konstantopoulou, M | 1 |
| Belgi, A | 1 |
| Griffiths, KD | 1 |
| Seale, JR | 1 |
| Macfarlane, AW | 1 |
| Frohman, EM | 1 |
| Havrdova, E | 1 |
| Levinson, B | 1 |
| del Pozo, J | 1 |
| Malmierca, NM | 1 |
| Yebra-Pimentel, MT | 1 |
| Almagro, M | 1 |
| Martínez, W | 1 |
| Martín, CG | 1 |
| Fonseca, E | 1 |
| Hagenah, GC | 1 |
| Wündisch, T | 1 |
| Eckstein, E | 1 |
| Zimmermann, S | 1 |
| Holst, F | 1 |
| Grimm, W | 1 |
| Neubauer, A | 1 |
| Lohoff, M | 1 |
| Reale, LD | 1 |
| Besa, EC | 1 |
| Stratta, P | 1 |
| Cremona, R | 1 |
| Lazzarich, E | 1 |
| Quaglia, M | 1 |
| Fenoglio, R | 1 |
| Canavese, C | 1 |
| Molyneux, G | 1 |
| Gibson, FM | 1 |
| Chen, CM | 1 |
| Marway, HK | 1 |
| McKeag, S | 1 |
| Mifsud, CV | 1 |
| Pilling, AM | 1 |
| Whayman, MJ | 1 |
| Turton, JA | 1 |
| Derijks, LJ | 1 |
| van Helden, RB | 1 |
| Hommes, DW | 1 |
| Stokkers, PC | 1 |
| DeWitte, DB | 1 |
| Buick, MK | 1 |
| Cyran, SE | 1 |
| Maisels, MJ | 1 |
| Paulus, HE | 1 |
| Bacon, BR | 1 |
| Treuhaft, WH | 1 |
| Goodman, AM | 1 |
| Escousse, A | 1 |
| Mousson, C | 1 |
| Santona, L | 1 |
| Zanetta, G | 1 |
| Mounier, J | 1 |
| Tanter, Y | 1 |
| Duperray, F | 1 |
| Rifle, G | 1 |
| Chevet, D | 1 |
| Ben Ari, Z | 1 |
| Mehta, A | 1 |
| Lennard, L | 2 |
| Burroughs, AK | 1 |
| De Lord, C | 1 |
| Marsh, JC | 1 |
| Smith, JG | 1 |
| Singer, CR | 1 |
| Gordon-Smith, EC | 1 |
| Kennedy, DT | 1 |
| Hayney, MS | 1 |
| Lake, KD | 1 |
| Leipold, G | 1 |
| Schütz, E | 1 |
| Haas, JP | 1 |
| Oellerich, M | 1 |
| Kim, CJ | 1 |
| Park, KI | 1 |
| Inoue, H | 1 |
| Yoshida, T | 1 |
| Yoshiki, T | 1 |
| Tomoyoshi, T | 1 |
| Abe, H | 1 |
| Kodama, M | 1 |
| Sako, H | 1 |
| Nakane, Y | 1 |
| Löwhagen, GB | 1 |
| Lindstedt, G | 1 |
| Stockhausen, G | 1 |
| Hopf, U | 1 |
| Glogner, P | 1 |
| Anstey, A | 1 |
| Mayou, SC | 1 |
| Kirby, JD | 1 |
| Nossent, JC | 1 |
| Swaak, AJ | 1 |
| Burke, DA | 1 |
| Dixon, MF | 1 |
| Axon, AT | 1 |
| Jeurissen, ME | 1 |
| Boerbooms, AM | 1 |
| van de Putte, LB | 1 |
| Patapanian, H | 1 |
| Graham, S | 1 |
| Sambrook, PN | 1 |
| Browne, CD | 1 |
| Champion, GD | 1 |
| Cohen, ML | 1 |
| Day, RO | 1 |
| Verhelst, JA | 1 |
| Van den Enden, E | 1 |
| Mathys, R | 1 |
| Greif, J | 1 |
| Erdmann, E | 1 |
| Alter, BP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Cyclophosphamide and Hydroxychloroquine for the Treatment of Severe Thrombocytopenia in Systemic Lupus Erythematosus[NCT02444728] | Phase 3 | 50 participants (Actual) | Interventional | 2015-07-31 | Terminated (stopped due to Because of insufficient enrollement) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for azathioprine and Pancytopenia
| Article | Year |
|---|---|
Clinical assessment and management of cytopenias in lupus patients.
Topics: Anemia; Antibodies, Monoclonal, Murine-Derived; Azathioprine; Glucocorticoids; Humans; Immunoglobuli | 2011 |
Rituximab in autoimmune pancytopenia: a case report and review of literature.
Topics: Adult; Anemia, Hemolytic, Autoimmune; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived | 2007 |
Pancytopenia related to azathioprine--an enzyme deficiency caused by a common genetic polymorphism: a review.
Topics: Azathioprine; Female; Humans; Methyltransferases; Middle Aged; Pancytopenia; Polymorphism, Genetic; | 1992 |
53 other studies available for azathioprine and Pancytopenia
| Article | Year |
|---|---|
Azathioprine Induced Pancytopenia in a Patient with Vogt-Koyanagi-Harada Disease: A Case Report.
Topics: Azathioprine; Humans; Immunosuppressive Agents; Male; Middle Aged; Pancytopenia; Prednisolone; Uveom | 2022 |
Visceral leishmaniasis masquerading as drug-induced pancytopenia in myasthenia gravis.
Topics: Azathioprine; Diagnosis, Differential; Humans; Immunosuppressive Agents; Leishmaniasis, Visceral; Ma | 2021 |
Azathioprine-Induced Pancytopenia and Septic Complications: A Probable Cause of Death.
Topics: Azathioprine; Fatal Outcome; Humans; Immunosuppressive Agents; Male; Middle Aged; Pancytopenia; Seps | 2018 |
Azathioprine-induced pancytopenia with normal TPMT activity presenting with HSV oral ulcers.
Topics: Aged; Azathioprine; Herpes Simplex; Humans; Immunosuppressive Agents; Male; Methyltransferases; Oral | 2018 |
Azathioprine-induced myelosuppression in two pemphigus vulgaris patients with homozygous polymorphism of NUDT15.
Topics: Adult; Azathioprine; Blood Cell Count; Coinfection; Drug Therapy, Combination; Female; Homozygote; H | 2019 |
[Secondary acute myeloid leukemia in a lung allograft recipient. Report of one case].
Topics: Azathioprine; Bone Marrow; Chromosomes, Human, Pair 5; Fatal Outcome; Female; Humans; Immunosuppress | 2015 |
Successful management of multilineage autoimmune cytopenia complicated with severe infection and deep vein thrombosis in a patient with Hodgkin lymphoma post-autologous hematopoietic stem cell transplantation.
Topics: Adolescent; Autoimmune Diseases; Azathioprine; Bone Marrow Transplantation; Cell Lineage; Cyclophosp | 2016 |
Idiopathic portal hypertension regarding thiopurine treatment in patients with inflammatory bowel disease.
Topics: Adult; Aged; Azathioprine; Cross-Sectional Studies; Female; Humans; Hypertension, Portal; Idiopathic | 2016 |
Mycophenolate mofetil as an alternative treatment for autoimmune hepatitis.
Topics: Alanine Transaminase; Alopecia; Antibiotics, Antineoplastic; Aspartate Aminotransferases; Azathiopri | 2016 |
[Azathioprine-induced pancytopenia: case series].
Topics: Adolescent; Azathioprine; Female; Humans; Immunosuppressive Agents; Pancytopenia | 2016 |
Paradoxical elevated thiopurine S-methyltransferase activity after pancytopenia during azathioprine therapy: potential influence of red blood cell age.
Topics: Adolescent; Azathioprine; Blood Cell Count; Crohn Disease; Erythrocyte Aging; Erythrocytes; Female; | 2008 |
Fatal myelotoxicity after azathioprine treatment.
Topics: Adult; Azathioprine; Bone Marrow; Colitis, Ulcerative; Drug-Related Side Effects and Adverse Reactio | 2008 |
Interaction of ribavirin with azathioprine metabolism potentially induces myelosuppression.
Topics: Adult; Antiviral Agents; Azathioprine; Drug Interactions; Female; Hepatitis C, Chronic; Humans; Immu | 2008 |
[Nodular regenerative hyperplasia as a side effect of azathioprine in a patient with Crohn's disease].
Topics: Ascites; Azathioprine; Blood Cell Count; Crohn Disease; Diagnosis, Differential; Fatigue; Focal Nodu | 2008 |
Autoimmune pancreatitis associated with myelodysplastic syndrome.
Topics: Aged; Amylases; Autoantibodies; Autoimmune Diseases; Azathioprine; Bile Ducts; Bilirubin; Blood Cell | 2010 |
Azathioprine plus ribavirin treatment and pancytopenia.
Topics: Adult; Anti-Inflammatory Agents; Antiviral Agents; Azathioprine; Crohn Disease; Drug Interactions; H | 2009 |
Bacillary angiomatosis in an immunosuppressed dog.
Topics: Angiomatosis, Bacillary; Animals; Anti-Bacterial Agents; Azathioprine; Azithromycin; Clindamycin; Do | 2010 |
[Azathioprine-associated severe myelosuppression: indication of routine determination of thiopurine S-methyltransferase variant?].
Topics: Antirheumatic Agents; Azathioprine; Female; Humans; Methyltransferases; Middle Aged; Mutation; Pancy | 2011 |
Azathioprine-related myelosuppression in a patient homozygous for TPMT*3A.
Topics: Azathioprine; Erythrocyte Transfusion; Filgrastim; Folic Acid; Genotype; Granulocyte Colony-Stimulat | 2011 |
Limitations of extensive TPMT genotyping in the management of azathioprine-induced myelosuppression in IBD patients.
Topics: Adolescent; Adult; Aged; Azathioprine; DNA Mutational Analysis; Drug Hypersensitivity; Female; Genot | 2011 |
[Visceral leishmaniasis diagnosed from a colon biopsy].
Topics: Adrenal Cortex Hormones; Aged; Amphotericin B; Antiprotozoal Agents; Azathioprine; Biopsy; Colitis, | 2012 |
Clinical and magnetic resonance imaging (MRI) findings of idiopathic aplastic pancytopenia in a dog treated with cyclosporine and azathioprine.
Topics: Animals; Azathioprine; Cyclosporine; Dog Diseases; Dogs; Female; Immunosuppressive Agents; Magnetic | 2012 |
Fever and pancytopenia in a patient with Crohn's disease.
Topics: Angiography; Antiviral Agents; Azathioprine; Cecum; Crohn Disease; Digestive System Surgical Procedu | 2013 |
Monitoring and assessing the safety of disease-modifying antirheumatic drugs: a West Midlands experience.
Topics: Antirheumatic Agents; Arthritis, Infectious; Azathioprine; Drug Monitoring; Humans; Hypokalemia; Lun | 2002 |
Severe pancytopenia from thiopurine methyltransferase deficiency: a preventable complication of 6-mercaptopurine therapy in children with Crohn disease.
Topics: Adolescent; Azathioprine; Child, Preschool; Crohn Disease; Female; Genotype; Humans; Immunosuppressi | 2002 |
Practical pharmacogenetics: the cost effectiveness of screening for thiopurine s-methyltransferase polymorphisms in patients with rheumatological conditions treated with azathioprine.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Azathioprine; Cost-Benefit Analysis; Decision Support T | 2002 |
[Azathioprine-associated myelodysplastic syndrome with cytogenetic aberrations].
Topics: Anemia; Azathioprine; Bone Marrow; Bone Marrow Examination; Chromosome Aberrations; Chromosomes, Hum | 2004 |
[Panzytopenia from combination therapy with azathioprin and allopurinol].
Topics: Aged; Allopurinol; Antirheumatic Agents; Autoantibodies; Azathioprine; Blood Cell Count; Diabetes Me | 2004 |
Azathioprine-induced pancytopenia in a patient with pompholyx and deficiency of erythrocyte thiopurine methyltransferase.
Topics: Azathioprine; Eczema, Dyshidrotic; Erythrocytes; Humans; Immunosuppressive Agents; Male; Methyltrans | 2005 |
Azathioprine myelosuppression in multiple sclerosis: characterizing thiopurine methyltransferase polymorphisms.
Topics: Adolescent; Azathioprine; Female; Genetic Variation; Homozygote; Humans; Immunosuppressive Agents; M | 2006 |
[Fatal Sweet syndrome associated to chronic idiopathic systemic inflammatory response syndrome].
Topics: Aged; Anti-Inflammatory Agents; Azathioprine; Biopsy; Chronic Disease; Colchicine; Fatal Outcome; Fe | 2007 |
[Sepsis-like disease in an immunocompromised patient with a travel history to Mallorca].
Topics: Adult; Animals; Azathioprine; Biopsy; Bone Marrow; Colectomy; Colitis, Ulcerative; Colon; Colonic Ne | 2007 |
Life-threatening systemic flare-up of systemic lupus erythematosus following influenza vaccination.
Topics: Anemia, Hemolytic, Autoimmune; Azathioprine; Female; Humans; Immunosuppressive Agents; Influenza Vac | 2008 |
The haemotoxicity of azathioprine in repeat dose studies in the female CD-1 mouse.
Topics: Animals; Apoptosis; Azathioprine; Body Weight; Bone Marrow Cells; Colony-Forming Units Assay; Diseas | 2008 |
Dosing azathioprine in thiopurine S-methyltransferase deficient inflammatory bowel disease patients.
Topics: Adult; Azathioprine; Colitis, Ulcerative; Humans; Immunosuppressive Agents; Male; Methyltransferases | 2008 |
Neonatal pancytopenia and severe combined immunodeficiency associated with antenatal administration of azathioprine and prednisone.
Topics: Adult; Azathioprine; Female; Fetus; Humans; Immunologic Deficiency Syndromes; Infant, Newborn; Male; | 1984 |
An overview of benefit/risk of disease modifying treatment of rheumatoid arthritis as of today.
Topics: Arthritis, Rheumatoid; Azathioprine; Chloroquine; Cyclophosphamide; Female; Gold; Humans; Hydroxychl | 1982 |
Azathioprine-induced pancytopenia. Occurrence in two patients with connective-tissue diseases.
Topics: Adult; Arthritis, Juvenile; Azathioprine; Blood Cell Count; Bone Marrow; Connective Tissue Diseases; | 1981 |
Azathioprine-induced pancytopenia in homozygous thiopurine methyltransferase-deficient renal transplant recipients: a family study.
Topics: Adult; Azathioprine; Erythrocytes; Female; Glomerulonephritis, IGA; Homozygote; Humans; Kidney Trans | 1995 |
Azathioprine-induced myelosuppression due to thiopurine methyltransferase deficiency in a patient with autoimmune hepatitis.
Topics: Adult; Autoimmune Diseases; Azathioprine; Bone Marrow Diseases; Hepatitis; Humans; Immunosuppressive | 1995 |
Fatal autoimmune pancytopenia following bone marrow transplantation for aplastic anaemia.
Topics: Adult; Anemia, Aplastic; Anemia, Hemolytic, Autoimmune; Aspergillosis; Autoantibodies; Autoimmune Di | 1996 |
Azathioprine and allopurinol: the price of an avoidable drug interaction.
Topics: Allopurinol; Azathioprine; Cost of Illness; Drug Interactions; Gout Suppressants; Heart Transplantat | 1996 |
Azathioprine-induced severe pancytopenia due to a homozygous two-point mutation of the thiopurine methyltransferase gene in a patient with juvenile HLA-B27-associated spondylarthritis.
Topics: Adolescent; Antirheumatic Agents; Arthritis; Azathioprine; Female; HLA-B27 Antigen; Homozygote; Huma | 1997 |
Azathioprine-induced megaloblastic anemia with pancytopenia 22 years after living-related renal transplantation.
Topics: Anemia, Megaloblastic; Azathioprine; Bone Marrow; Female; Humans; Kidney Transplantation; Middle Age | 1998 |
[Bone marrow depression after azathioprine. New discoveries on an old drug].
Topics: Aged; Antimetabolites, Antineoplastic; Azathioprine; Bone Marrow Cells; Female; Genotype; Hematologi | 2000 |
[Pancytopenia following a combination therapy with allopurinol and azathioprine. Discussion contribution and conclusion].
Topics: Allopurinol; Azathioprine; Drug Therapy, Combination; Humans; Male; Middle Aged; Pancytopenia | 1977 |
Pancytopenia in systemic lupus erythematosus related to azathioprine.
Topics: Adult; Azathioprine; Female; Humans; Lupus Erythematosus, Systemic; Pancytopenia | 1990 |
Ulcerative colitis: prolonged remission following azathioprine-induced pancytopenia.
Topics: Adult; Azathioprine; Biopsy; Colitis, Ulcerative; Female; Humans; Pancytopenia; Rectum; Remission In | 1989 |
Pancytopenia related to azathioprine in rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Azathioprine; Female; Humans; Male; Pancytopenia | 1988 |
The oncogenicity of chlorambucil in rheumatoid arthritis.
Topics: Acute Disease; Arthritis, Rheumatoid; Azathioprine; Carcinogens; Chlorambucil; Humans; Leukemia, Mye | 1988 |
Rapidly evolving azathioprine induced pancytopenia.
Topics: Arthritis, Rheumatoid; Azathioprine; Female; Humans; Middle Aged; Pancytopenia | 1987 |
[Life-threatening interaction between azathioprine and allopurinol].
Topics: Allopurinol; Azathioprine; Chemical and Drug Induced Liver Injury; Drug Synergism; Drug Therapy, Com | 1985 |
Neonatal pancytopenia after maternal azathioprine therapy.
Topics: Azathioprine; Female; Humans; Infant, Newborn; Pancytopenia; Pregnancy; Prenatal Exposure Delayed Ef | 1985 |