azathioprine and Pancreatitis studies

Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.

Pancreatitis: INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis.

Research Excerpts

Excerpt	Relevance	Reference
"A case of acute pancreatitis induced by azathioprine presented in a 22-year-old patient with Crohn's disease is reported."	8.80	[Acute azathioprine-induced pancreatitis in a female patient with Crohn's disease]. ( Caro-Paton, A; Fernández, P; González, JM; Goyeneche, ML; Martín, MA; Remacha, B; Sánchez, G; Velicia, MR, 1999)
"The immunosuppressant drug azathioprine is associated with a 4% risk of acute pancreatitis in patients with inflammatory bowel disease (IBD)."	8.12	HLA variants associated with azathioprine-induced pancreatitis in patients with Crohn's disease. ( Ås, J; Bertulyte, I; Eriksson, N; Hallberg, P; Magnusson, PKE; Wadelius, M, 2022)
"Azathioprine (AZA)-induced pancreatitis (AIP) is a common, idiosyncratic adverse effect whose incidence and risk factors data in inflammatory bowel disease (IBD) patients are not fully clarified."	8.12	Finding Predictors of Azathioprine-Induced Pancreatitis in Patients With Inflammatory Bowel Disease. ( Arieira, C; Cotter, J; Cúrdia Gonçalves, T; Dias de Castro, F; Firmino-Machado, J; Freitas, M; Lima Capela, T; Macedo Silva, V; Moreira, MJ, 2022)
"The aim of the study was to identify the frequency of azathioprine-induced acute pancreatitis (AZA-AP) and related factors."	8.02	Frequency, Predisposing Factors, and Clinical Outcome of Azathioprine-Induced Pancreatitis Among Patients With Inflammatory Bowel Disease: Results From a Tertiary Referral Center. ( Atay, K; Bozcan, S; Celik, AF; Celik, S; Demir, N; Erzin, Y; Eskazan, T; Hatemi, I; Tuncer, M; Yildirim, S, 2021)
"Azathioprine-induced pancreatitis is an idiosyncratic and unpredictable response, occurring in up to 7% of azathioprine-exposed patients with inflammatory bowel disease (IBD)."	8.02	Pretreatment HLADQA1-HLADRB1 Testing for the Prevention of Azathioprine-Induced Pancreatitis in Inflammatory Bowel Disease: A Prospective Cohort Study. ( Beaton, M; Chande, N; Choi, YH; Gregor, JC; Kim, RB; Ponich, T; Sey, M; Wang, Q; Wilson, A; Yan, B, 2021)
"Studies have shown an association between use of azathioprine and increased risk of acute pancreatitis in adult inflammatory bowel disease."	7.91	Association between use of azathioprine and risk of acute pancreatitis in children with inflammatory bowel disease: a Swedish-Danish nationwide cohort study. ( Ludvigsson, JF; Melbye, M; Olén, O; Pasternak, B; Svanström, H; Wintzell, V, 2019)
"Azathioprine (AZA)-induced pancreatitis is an unpredictable and dose-independent adverse event affecting 2%-7% of patients with inflammatory bowel disease (IBD) patients treated with AZA."	7.88	HLA-DQA1-HLA-DRB1 polymorphism is a major predictor of azathioprine-induced pancreatitis in patients with inflammatory bowel disease. ( Beaton, M; Chande, N; Gregor, JC; Jairath, V; Jansen, LE; Khanna, N; Khanna, R; Kim, RB; McIntosh, K; Ponich, T; Rose, RV; Sey, M; Teft, WA; Wilson, A; Yan, B, 2018)
"We describe two children with CD in whom MP were successfully trialled after a confirmed azathioprine-induced pancreatitis, being well tolerated in both cases."	7.81	Successful Mercaptopurine Usage despite Azathioprine-Induced Pancreatitis in Paediatric Crohn's Disease. ( Bartosova, L; Blasco-Alonso, J; Fernández-Crehuet, FG; Gallego-Gutiérrez, S; García-Galán, P; Kolorz, M; Lukac, K; Luque-Pérez, S; Navas-López, VM; Núñez-Caro, L; Serrano-Nieto, MJ; Sierra-Salinas, C, 2015)
"In this case, the combination of steroids with tacrolimus seems to be a reasonable alternative in a patient with steroid-dependent and thiopurine-refractory autoimmune pancreatitis with IgG4-associated cholangitis."	7.80	Tacrolimus as a reasonable alternative in a patient with steroid-dependent and thiopurine-refractory autoimmune pancreatitis with IgG4-associated cholangitis. ( Buechter, M; Canbay, A; Gerken, G; Kahraman, A; Klein, CG; Kloeters, C; Schlaak, JF, 2014)
"Azathioprine induced pancreatitis usually runs a benign self limited course with rapid disappearance of signs and symptoms upon with drawl of the drug."	7.77	Azathioprine induced pancreatitis in a patient with co-existing autoimmune pancreatitis and hepatitis. ( Navaneethan, U; Venkatesh, PG, 2011)
"We hypothesized that the presence of pancreatic autoantibodies in Crohn's disease patients is associated with the development of azathioprine-induced pancreatitis."	7.74	Are pancreatic autoantibodies associated with azathioprine-induced pancreatitis in Crohn's disease? ( Batstra, MR; Kleibeuker, JH; van Dullemen, HM; Weersma, RK, 2008)
"Azathioprine has been linked to subsequent acute pancreatitis in several case reports and small case series."	7.72	Risk of acute pancreatitis in users of azathioprine: a population-based case-control study. ( Floyd, A; Nielsen, GL; Pedersen, L; Sorensen, HT; Thorlacius-Ussing, O, 2003)
"We have described a 22-year-old man with an HBsAg-positive chronic active hepatitis who developed an attack of pancreatitis during the course of treatment with prednisone and azathioprine."	7.67	Azathioprine-associated acute pancreatitis in the course of chronic active hepatitis. ( Grandjean, E; Guillaume, P; Malè, PJ, 1984)
"Acute pancreatitis was diagnosed in 2 dogs given azathioprine and prednisone."	7.67	Acute pancreatitis in two dogs given azathioprine and prednisone. ( Bowen, D; Meyer, DJ; Moriello, KA, 1987)
" Acute pancreatitis developed, which we could not relate to her lupus, prednisone administration, viral illness, or other causes."	7.66	Acute pancreatitis associated with long-term azathioprine therapy. Occurrence in a patient with systemic lupus erythematosus. ( Herskowitz, LJ; Lang, PG; Olansky, S, 1979)
"Recent controlled clinical trials have documented the development of acute pancreatitis in 5% of patients receiving azathioprine for Crohn's disease, by far the highest incidence of drug-induced pancreatitis recorded to date."	7.66	Azathioprine and acute pancreatitis: studies with an isolated perfused canine pancreas. ( Broe, PJ; Cameron, JL, 1983)
"A retrospective review of the literature has been carried out to determine laboratory abnormalities occurring in patients with rheumatoid arthritis (RA) treated with azathioprine, in order to establish a profile for this agent in the treatment of this disease."	7.66	Rheumatoid arthritis: treatment with azathioprine (IMURAN (R)). Clinical side-effects and laboratory abnormalities. ( Pelkey, J; Whisnant, JK, 1982)
"Azathioprine therapy in a patient with granulomatous ileocolitis was associated with an attack of acute pancreatitis, which was confirmed by laparotomy."	7.65	Azathioprine-associated acute pancreatitis. ( Levin, B; Paloyan, D; Simonowitz, D, 1977)
"Azathioprine (AZA) is a commonly used immunosuppressive therapy that has been implicated in a number of cutaneous and systemic inflammatory reactions."	5.91	Azathioprine hypersensitivity syndrome manifesting as subcutaneous Sweet syndrome and acute pancreatitis. ( Harp, J; Magro, C; Tee, MW; Thomas, JL, 2023)
"Drug-induced acute pancreatitis (DIAP) is an often-neglected entity where the disorder is the consequence of the toxic effects of various agents applied to treat potentially life-threatening conditions, such as inflammatory bowel disease."	5.56	Recurrent acute pancreatitis induced by 5-ASA and azathioprine in ulcerative colitis. ( Bajor, J; Faluhelyi, N; Hegyi, P; Hegyi, PJ; Németh, BC; Szakács, Z, 2020)
" Oral prednisolone treatment was initiated at 30 mg/day, and the dosage was gradually decreased."	5.43	A case of autoimmune pancreatitis effectively treated with an immunosuppressant (azathioprine). ( Arakawa, N; Fujisawa, M; Igarashi, R; Ikeda, T; Irisawa, A; Maki, T; Notohara, K; Sato, A; Shibukawa, G; Yamabe, A; Yamamoto, S; Yoshida, Y, 2016)
"AZA-induced acute pancreatitis is a common adverse event in IBD patients, but in this study had a mild course in all patients."	5.43	Azathioprine-induced Acute Pancreatitis in Patients with Inflammatory Bowel Diseases--A Prospective Study on Incidence and Severity. ( Bokemeyer, B; Bündgens, B; Büning, J; Drabik, A; Helwig, U; Hüppe, D; Klugmann, T; Kruis, W; Maaser, C; Miehlke, S; Mohl, W; Siegmund, B; Stallmach, A; Teich, N; Weismüller, J, 2016)
"In addition, acute pancreatitis is one of the extra-intestinal manifestations of acute exacerbation of CD without the previous use of azathioprine."	5.35	[Acute pancreatitis following azathioprine therapy of crohn's disease--a case report and the overview of the literature]. ( Koren, M; Potrc, S; Sinkovic, A; Skok, P, 2008)
"Sclerosing sialadenitis occurred before AIP, whereas autoimmune sensorineural hearing loss, allergic purpura and endocapillary proliferative glomerulonephritis occurred after AIP."	5.35	Autoimmune pancreatitis associated with various extrapancreatic lesions during a long-term clinical course successfully treated with azathioprine and corticosteroid maintenance therapy. ( Ando, T; Hayashi, K; Joh, T; Miyabe, K; Naitoh, I; Nakazawa, T; Ohara, H; Okumura, F; Sano, H; Takahashi, S; Tanaka, H; Yoshida, M, 2009)
"Pancreatitis is a potentially severe condition."	5.35	Acute pancreatitis in inflammatory bowel disease, with special reference to azathioprine-induced pancreatitis. ( Algaba, A; Bermejo, F; Calvo, M; Carneros, JA; Gisbert, JP; López, P; Lopez-Sanroman, A; Luna, M; Martín-Arranz, MD; Menchén, L; Mendoza, JL; Opio, V; Pérez-Calle, JL; Taxonera, C; Van-Domselaar, M; Vera, I, 2008)
"Acute pancreatitis is rarely seen when azathioprine is used for other diseases than Crohn's disease."	5.32	Increased incidence of azathioprine-induced pancreatitis in Crohn's disease compared with other diseases. ( Homan van der Heide, JJ; Jansen, PL; Oostenbrug, LE; Peters, FT; Ploeg, RJ; Posthumus, MD; van den Berg, AP; van Dullemen, HM; van Haastert, M; Weersma, RK, 2004)
" The thiopurine drugs, azathioprine and 6-mercaptopurine, are commonly used to maintain remission in Crohn's disease and ulcerative colitis; however, the use of these drugs may be limited by the development of pancreatitis in some individuals."	4.91	Thiopurine-induced pancreatitis in inflammatory bowel diseases. ( Day, AS; Ledder, O; Lemberg, DA, 2015)
"A case of acute pancreatitis induced by azathioprine presented in a 22-year-old patient with Crohn's disease is reported."	4.80	[Acute azathioprine-induced pancreatitis in a female patient with Crohn's disease]. ( Caro-Paton, A; Fernández, P; González, JM; Goyeneche, ML; Martín, MA; Remacha, B; Sánchez, G; Velicia, MR, 1999)
" Less convincing, but suggestive evidence exists for: 1-asparaginase, iatrogenic hypercalcemia, chlorthalidine, corticosteroids, ethacrynic acid, phenformin, and procainamide."	4.76	Drug-induced pancreatitis: a critical review. ( Kern, F; Mallory, A, 1980)
" Fifty-one instances were caused by steroids or adrenocorticotropic hormone, six by estrogen, two by azathioprine, 16 by diurectics, two by hypercalcemia, 24 by chemotherapy, three by clonidine and phenformin, two by warfarin and one each by salicylate, 1-asparaginase and d-propoxyphene."	4.75	Drug-induced acute pancreatitis. ( Howard, JM; Nakashima, Y, 1977)
"Azathioprine (AZA)-induced pancreatitis (AIP) is a common, idiosyncratic adverse effect whose incidence and risk factors data in inflammatory bowel disease (IBD) patients are not fully clarified."	4.12	Finding Predictors of Azathioprine-Induced Pancreatitis in Patients With Inflammatory Bowel Disease. ( Arieira, C; Cotter, J; Cúrdia Gonçalves, T; Dias de Castro, F; Firmino-Machado, J; Freitas, M; Lima Capela, T; Macedo Silva, V; Moreira, MJ, 2022)
"The immunosuppressant drug azathioprine is associated with a 4% risk of acute pancreatitis in patients with inflammatory bowel disease (IBD)."	4.12	HLA variants associated with azathioprine-induced pancreatitis in patients with Crohn's disease. ( Ås, J; Bertulyte, I; Eriksson, N; Hallberg, P; Magnusson, PKE; Wadelius, M, 2022)
"Azathioprine-induced pancreatitis is an idiosyncratic and unpredictable response, occurring in up to 7% of azathioprine-exposed patients with inflammatory bowel disease (IBD)."	4.02	Pretreatment HLADQA1-HLADRB1 Testing for the Prevention of Azathioprine-Induced Pancreatitis in Inflammatory Bowel Disease: A Prospective Cohort Study. ( Beaton, M; Chande, N; Choi, YH; Gregor, JC; Kim, RB; Ponich, T; Sey, M; Wang, Q; Wilson, A; Yan, B, 2021)
"The aim of the study was to identify the frequency of azathioprine-induced acute pancreatitis (AZA-AP) and related factors."	4.02	Frequency, Predisposing Factors, and Clinical Outcome of Azathioprine-Induced Pancreatitis Among Patients With Inflammatory Bowel Disease: Results From a Tertiary Referral Center. ( Atay, K; Bozcan, S; Celik, AF; Celik, S; Demir, N; Erzin, Y; Eskazan, T; Hatemi, I; Tuncer, M; Yildirim, S, 2021)
"Studies have shown an association between use of azathioprine and increased risk of acute pancreatitis in adult inflammatory bowel disease."	3.91	Association between use of azathioprine and risk of acute pancreatitis in children with inflammatory bowel disease: a Swedish-Danish nationwide cohort study. ( Ludvigsson, JF; Melbye, M; Olén, O; Pasternak, B; Svanström, H; Wintzell, V, 2019)
"Azathioprine (AZA)-induced pancreatitis is an unpredictable and dose-independent adverse event affecting 2%-7% of patients with inflammatory bowel disease (IBD) patients treated with AZA."	3.88	HLA-DQA1-HLA-DRB1 polymorphism is a major predictor of azathioprine-induced pancreatitis in patients with inflammatory bowel disease. ( Beaton, M; Chande, N; Gregor, JC; Jairath, V; Jansen, LE; Khanna, N; Khanna, R; Kim, RB; McIntosh, K; Ponich, T; Rose, RV; Sey, M; Teft, WA; Wilson, A; Yan, B, 2018)
"We describe two children with CD in whom MP were successfully trialled after a confirmed azathioprine-induced pancreatitis, being well tolerated in both cases."	3.81	Successful Mercaptopurine Usage despite Azathioprine-Induced Pancreatitis in Paediatric Crohn's Disease. ( Bartosova, L; Blasco-Alonso, J; Fernández-Crehuet, FG; Gallego-Gutiérrez, S; García-Galán, P; Kolorz, M; Lukac, K; Luque-Pérez, S; Navas-López, VM; Núñez-Caro, L; Serrano-Nieto, MJ; Sierra-Salinas, C, 2015)
"In this case, the combination of steroids with tacrolimus seems to be a reasonable alternative in a patient with steroid-dependent and thiopurine-refractory autoimmune pancreatitis with IgG4-associated cholangitis."	3.80	Tacrolimus as a reasonable alternative in a patient with steroid-dependent and thiopurine-refractory autoimmune pancreatitis with IgG4-associated cholangitis. ( Buechter, M; Canbay, A; Gerken, G; Kahraman, A; Klein, CG; Kloeters, C; Schlaak, JF, 2014)
"Mesalamine and thiopurines (6-mercaptopurine and azathioprine) have been shown to increase the risk of developing acute pancreatitis in inflammatory bowel disease (IBD) patients."	3.80	Effect of tumor necrosis factor-α inhibitors on drug-induced pancreatitis in inflammatory bowel disease. ( Deepak, P; Stobaugh, DJ, 2014)
"Pancreatitis occurs in approximately 4% of patients treated with the thiopurines azathioprine or mercaptopurine."	3.80	HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants. ( Ahmad, T; Andrews, JM; Annese, V; Bampton, P; Barnardo, M; Bell, S; Bewshea, CM; Chen, M; Cole, A; Connor, SJ; Creed, T; Cummings, FR; D'Amato, M; Daneshmend, TK; Dubois, PC; Fedorak, RN; Florin, TH; Gaya, DR; Greig, E; Halfvarson, J; Hart, A; Heap, GA; Holden, AL; Irving, PM; Jones, G; Karban, A; Lawrance, IC; Lee, JC; Lees, C; Lev-Tzion, R; Lindsay, JO; Mansfield, J; Mawdsley, J; Mazhar, Z; Orchard, TR; Parkes, M; Parnell, K; Radford-Smith, G; Reffitt, D; Rossjohn, J; Russell, RK; Satchwell, JB; Satsangi, J; Silverberg, MS; Singh, A; So, K; Sturniolo, GC; Tremelling, M; Tsianos, EV; van Heel, DA; Vivian, JP; Walsh, A; Watermeyer, G; Weedon, MN; Weersma, RK; Zeissig, S, 2014)
" Four cases are presented of TIP appropriately related temporally to azathioprine commencement, with no other apparent cause of pancreatitis identified."	3.79	Are thiopurines always contraindicated after thiopurine-induced pancreatitis in inflammatory bowel disease? ( Day, AS; Ledder, OD; Lemberg, DA; Ooi, CY, 2013)
"Azathioprine induced pancreatitis usually runs a benign self limited course with rapid disappearance of signs and symptoms upon with drawl of the drug."	3.77	Azathioprine induced pancreatitis in a patient with co-existing autoimmune pancreatitis and hepatitis. ( Navaneethan, U; Venkatesh, PG, 2011)
"We hypothesized that the presence of pancreatic autoantibodies in Crohn's disease patients is associated with the development of azathioprine-induced pancreatitis."	3.74	Are pancreatic autoantibodies associated with azathioprine-induced pancreatitis in Crohn's disease? ( Batstra, MR; Kleibeuker, JH; van Dullemen, HM; Weersma, RK, 2008)
" Azathioprine has a significant early adverse reaction (EAR) profile, which includes an acute syndrome of constitutional symptoms, fever, rash, and acute pancreatitis and often requires discontinuation of drug."	3.73	Increased rates of early adverse reaction to azathioprine in patients with Crohn's disease compared to autoimmune hepatitis: a tertiary referral center experience. ( Bajaj, JS; Binion, DG; Emmons, J; Franco, J; Knox, JF; Levy, M; Podoll, J; Saeian, K; Varma, RR, 2005)
"Of all azathioprine treated patients, 11 experienced an adverse event for which azathioprine was stopped: pancreatitis (n = 4), leucopenia (n = 2) and 'general malaise' (n = 5)."	3.73	Pharmacogenetics of thiopurine therapy in paediatric IBD patients. ( Benninga, MA; De Ridder, L; Escher, JC; Hommes, DW; Stokkers, PC; Van der Woude, JC; Van Deventer, HJ; Van Dieren, JM; Van Vuuren, AJ, 2006)
"Azathioprine has been linked to subsequent acute pancreatitis in several case reports and small case series."	3.72	Risk of acute pancreatitis in users of azathioprine: a population-based case-control study. ( Floyd, A; Nielsen, GL; Pedersen, L; Sorensen, HT; Thorlacius-Ussing, O, 2003)
" The intracystic hemorrhage in our case may have been related to a rapid tumor growth due to weakened antitumor immunity and azathioprine-induced pancreatitis."	3.70	Intracystic hemorrhage of pancreatic serous cystadenoma after renal transplantation: report of a case. ( Baba, S; Fujita, K; Harada, M; Ishikawa, A; Konno, H; Nakamura, S; Sakaguchi, T; Suzuki, K; Suzuki, S; Ushiyama, T, 2000)
"We have described a 22-year-old man with an HBsAg-positive chronic active hepatitis who developed an attack of pancreatitis during the course of treatment with prednisone and azathioprine."	3.67	Azathioprine-associated acute pancreatitis in the course of chronic active hepatitis. ( Grandjean, E; Guillaume, P; Malè, PJ, 1984)
"Acute pancreatitis was diagnosed in 2 dogs given azathioprine and prednisone."	3.67	Acute pancreatitis in two dogs given azathioprine and prednisone. ( Bowen, D; Meyer, DJ; Moriello, KA, 1987)
" Acute pancreatitis developed, which we could not relate to her lupus, prednisone administration, viral illness, or other causes."	3.66	Acute pancreatitis associated with long-term azathioprine therapy. Occurrence in a patient with systemic lupus erythematosus. ( Herskowitz, LJ; Lang, PG; Olansky, S, 1979)
"A retrospective review of the literature has been carried out to determine laboratory abnormalities occurring in patients with rheumatoid arthritis (RA) treated with azathioprine, in order to establish a profile for this agent in the treatment of this disease."	3.66	Rheumatoid arthritis: treatment with azathioprine (IMURAN (R)). Clinical side-effects and laboratory abnormalities. ( Pelkey, J; Whisnant, JK, 1982)
"Recent controlled clinical trials have documented the development of acute pancreatitis in 5% of patients receiving azathioprine for Crohn's disease, by far the highest incidence of drug-induced pancreatitis recorded to date."	3.66	Azathioprine and acute pancreatitis: studies with an isolated perfused canine pancreas. ( Broe, PJ; Cameron, JL, 1983)
"Azathioprine therapy in a patient with granulomatous ileocolitis was associated with an attack of acute pancreatitis, which was confirmed by laparotomy."	3.65	Azathioprine-associated acute pancreatitis. ( Levin, B; Paloyan, D; Simonowitz, D, 1977)
"Our cases demonstrate resemblances with autoimmune pancreatitis based on clinical and imaging findings."	3.01	Immune Checkpoint Inhibitor-related Pancreatitis: A Case Series, Review of the Literature and an Expert Opinion. ( Blokzijl, H; Kramer, S; van der Heide, F; van Hee, K; Visschedijk, MC, 2023)
"The risk of acute pancreatitis in patients with IBD is increased due to the higher incidence of cholelithiasis and drug-induced pancreatitis in this population."	2.82	Pancreatic Disorders in Patients with Inflammatory Bowel Disease. ( Bi, Y; Corral, JE; Farraye, FA; Ji, B; Kröner, PT; Lukens, FJ; Montenegro, ML, 2022)
"Acute pancreatitis is an uncommon complication that occurs in 0."	2.61	Corticosteroid-associated lupus pancreatitis: a case series and systematic review of the literature. ( Adarsh, MB; Dhir, V; Dhooria, A; Dwivedi, P; Jain, S; Kakkar, N; Kumar, RR; Malhotra, S; Naidu, S; Sharma, A; Sharma, SK, 2019)
" Fortunately, the absolute incidence of serious toxicity remains low, and an improved understanding of how best to minimize risk and the recognition of groups of patients at higher risk of toxicity from thiopurines means that they remain a relatively safe therapy in the majority of patients."	2.52	Toxicity and response to thiopurines in patients with inflammatory bowel disease. ( Goldberg, R; Irving, PM, 2015)
" Patients' derived iPSC are an innovative model to study mechanisms of adverse drug reactions in individual patients and in cell types that cannot be easily obtained from human subjects."	2.52	Patients' Induced Pluripotent Stem Cells to Model Drug Induced Adverse Events: A Role in Predicting Thiopurine Induced Pancreatitis? ( Decorti, G; Giliani, S; Lanzi, G; Martelossi, S; Pelin, M; Sasaki, K; Stocco, G; Tommasini, A; Ventura, A; Yue, F, 2015)
"Crohn's disease and ulcerative colitis, together popularly known as inflammatory bowel disease (IBD), are characterized by a number of extraintestinal manifestations."	2.46	Pancreatitis in inflammatory bowel diseases. ( Das, K; Pitchumoni, CS; Rubin, A, 2010)
" Adverse effects occur in about 15% of patients."	2.40	Azathioprine in inflammatory bowel disease, a safe alternative? ( Tanis, AA, 1998)
"Azathioprine (AZA) is a commonly used immunosuppressive therapy that has been implicated in a number of cutaneous and systemic inflammatory reactions."	1.91	Azathioprine hypersensitivity syndrome manifesting as subcutaneous Sweet syndrome and acute pancreatitis. ( Harp, J; Magro, C; Tee, MW; Thomas, JL, 2023)
"Thioguanine (TG) has been shown as a safe alternative in adults with inflammatory bowel disease (IBD) who did not tolerate conventional thiopurines [azathioprine (AZA)/mercaptopurine]."	1.72	Safety of Thioguanine in Pediatric Inflammatory Bowel Disease: A Multi-Center Case Series. ( Bayoumy, AB; Benninga, MA; de Boer, NKH; de Meij, TGJ; de Ridder, L; Hummel, T; Jagt, JZ; Mulder, CJJ; Stapelbroek, J; van Wering, HM; Wolters, VM, 2022)
" In this report, we describe the safe and effective use of trametinib combined with dasatinib in a patient with acute lymphoblastic leukemia (ALL)."	1.62	Successful use of trametinib and dasatinib combined with chemotherapy in the treatment of Ph-positive B-cell acute lymphoblastic leukemia: A case report. ( Hu, BF; Shen, SH; Wang, GL; Wang, J, 2021)
"Drug-induced acute pancreatitis (DIAP) is an often-neglected entity where the disorder is the consequence of the toxic effects of various agents applied to treat potentially life-threatening conditions, such as inflammatory bowel disease."	1.56	Recurrent acute pancreatitis induced by 5-ASA and azathioprine in ulcerative colitis. ( Bajor, J; Faluhelyi, N; Hegyi, P; Hegyi, PJ; Németh, BC; Szakács, Z, 2020)
"After exclusion of pancreatic cancer and other common causes of acute pancreatitis, the diagnosis of AIP was suspected."	1.48	Autoimmune Pancreatitis and Ulcerative Rectocolitis in an Adolescent. ( Aziz, K; Breton, E; Chailloux, P; Cousin, E; Cousin, I, 2018)
"However, disease relapse is common in long-term follow-up, despite a successful initial treatment response."	1.48	Relapse rate and predictors of relapse in a large single center cohort of type 1 autoimmune pancreatitis: long-term follow-up results after steroid therapy with short-duration maintenance treatment. ( Cho, DH; Jun, JH; Kim, MH; Lee, HW; Lee, SK; Lee, SS; Moon, SH; Nam, K; Park, DH; Seo, DW; Song, TJ, 2018)
"AZA-induced acute pancreatitis is a common adverse event in IBD patients, but in this study had a mild course in all patients."	1.43	Azathioprine-induced Acute Pancreatitis in Patients with Inflammatory Bowel Diseases--A Prospective Study on Incidence and Severity. ( Bokemeyer, B; Bündgens, B; Büning, J; Drabik, A; Helwig, U; Hüppe, D; Klugmann, T; Kruis, W; Maaser, C; Miehlke, S; Mohl, W; Siegmund, B; Stallmach, A; Teich, N; Weismüller, J, 2016)
" Oral prednisolone treatment was initiated at 30 mg/day, and the dosage was gradually decreased."	1.43	A case of autoimmune pancreatitis effectively treated with an immunosuppressant (azathioprine). ( Arakawa, N; Fujisawa, M; Igarashi, R; Ikeda, T; Irisawa, A; Maki, T; Notohara, K; Sato, A; Shibukawa, G; Yamabe, A; Yamamoto, S; Yoshida, Y, 2016)
" The major drawback of these drugs are their serious adverse effects (SAE), highlighting the importance of preemptive identification of patients at risk."	1.39	Risk factors for serious adverse effects of thiopurines in patients with Crohn's disease. ( Chowers, Y; Efrati, E; Elkin, H; Karban, A; Koifman, E; Krivoy, N; Mazor, Y, 2013)
"While causes of pancreatitis have been extensively analyzed, different series reported different causes."	1.38	Acute and recurrent pancreatitis in children: exploring etiological factors. ( De Cunto, A; Martelossi, S; Minen, F; Ventura, A, 2012)
"We report 2 cases of thiopurine-induced acute pancreatitis in patients with inflammatory bowel disease."	1.38	[Two cases of thiopurine-induced acute pancreatitis in inflammatory bowel disease]. ( Ando, T; Fujinami, H; Hosokawa, A; Kajiura, S; Kudo, T; Mihara, H; Miyazaki, T; Nishikawa, J; Ogawa, K; Sugiyama, T; Ueda, A, 2012)
"The probability of AIP recurrence was assessed by using Kaplan-Meier curves and the unadjusted Cox model."	1.37	Autoimmune pancreatitis: pancreatic and extrapancreatic MR imaging-MR cholangiopancreatography findings at diagnosis, after steroid therapy, and at recurrence. ( Bonatti, M; Frulloni, L; Graziani, R; Manfredi, R; Mantovani, W; Pozzi Mucelli, R, 2011)
"Azathioprine was the most frequent causative factor (three cases in two patients); all the other causative drugs were documented only in single cases: mesalazine, dexamethasone, ramipril, mycophenolate mofetil, cytarabine, and valproate."	1.36	Incidence, severity, and etiology of drug-induced acute pancreatitis. ( Procházka, M; Procházka, V; Urbánek, K; Vinklerová, I, 2010)
"Pancreatitis is a potentially severe condition."	1.35	Acute pancreatitis in inflammatory bowel disease, with special reference to azathioprine-induced pancreatitis. ( Algaba, A; Bermejo, F; Calvo, M; Carneros, JA; Gisbert, JP; López, P; Lopez-Sanroman, A; Luna, M; Martín-Arranz, MD; Menchén, L; Mendoza, JL; Opio, V; Pérez-Calle, JL; Taxonera, C; Van-Domselaar, M; Vera, I, 2008)
"Sclerosing sialadenitis occurred before AIP, whereas autoimmune sensorineural hearing loss, allergic purpura and endocapillary proliferative glomerulonephritis occurred after AIP."	1.35	Autoimmune pancreatitis associated with various extrapancreatic lesions during a long-term clinical course successfully treated with azathioprine and corticosteroid maintenance therapy. ( Ando, T; Hayashi, K; Joh, T; Miyabe, K; Naitoh, I; Nakazawa, T; Ohara, H; Okumura, F; Sano, H; Takahashi, S; Tanaka, H; Yoshida, M, 2009)
"Acute pancreatitis is a serious disease with fatality rate up to 15%."	1.35	[A case of acute pancreatitis induced by multiple drugs in a patient with ulcerative colitis]. ( Choi, HS; Hahm, JS; Han, DS; Joo, YW; Lee, HL; Lee, OY; Son, CN; Yoon, BC, 2008)
"In addition, acute pancreatitis is one of the extra-intestinal manifestations of acute exacerbation of CD without the previous use of azathioprine."	1.35	[Acute pancreatitis following azathioprine therapy of crohn's disease--a case report and the overview of the literature]. ( Koren, M; Potrc, S; Sinkovic, A; Skok, P, 2008)
"Two patients developed acute pancreatitis."	1.34	Thiopurine metabolite monitoring in paediatric inflammatory bowel disease. ( Bohane, TD; Day, AS; Lee, D; Naidoo, D; Ooi, CY, 2007)
"61); among the 34 responders, the median dosage of the drug required to obtain remission was lower for mutated than for wild type patients (1."	1.33	TPMT genotype and the use of thiopurines in paediatric inflammatory bowel disease. ( Barabino, A; Bartoli, F; Decorti, G; Fezzi, M; Fontana, M; Giraldi, T; Lionetti, P; Malusà, N; Martelossi, S; Stocco, G; Ventura, A, 2005)
"Acute pancreatitis is rarely seen when azathioprine is used for other diseases than Crohn's disease."	1.32	Increased incidence of azathioprine-induced pancreatitis in Crohn's disease compared with other diseases. ( Homan van der Heide, JJ; Jansen, PL; Oostenbrug, LE; Peters, FT; Ploeg, RJ; Posthumus, MD; van den Berg, AP; van Dullemen, HM; van Haastert, M; Weersma, RK, 2004)
"Pancreatitis is the most severe complication of ERCP."	1.32	Are drugs a risk factor of post-ERCP pancreatitis? ( Bauret, P; Berthier, E; Blanc, F; Blayac, JP; Fabbro-Peray, P; Hanslik, B; Hillaire-Buys, D; Larrey, D; Melki, M; Pageaux, GP; Perney, P; Roques, V, 2003)
"The mortality of acute pancreatitis in a kidney transplant patient is, in spite of treatment with the most up-to-date methods, is much higher (53-60%) than that for a non-transplant patient."	1.31	[Acute pancreatitis after kidney transplantation]. ( Asztalos, L; Balzs, G; Berczi, C; Fedor, R; Kincses, Z; Locsey, L; Szabo, L, 2001)
"Pancreatitis was significantly more frequent in girls as compared to boys (P = 0."	1.31	[Pancreatic involvement in inflammatory bowel diseases in children]. ( Cézard, JP; Faure, C; Hugot, JP; Le Large-Guiheneuf, C; Mougenot, JF; Munck, A; Navarro, J, 2002)
"Acute pancreatitis was induced in rats by using a combination of low-dose controlled intraductal glycodeoxycholic acid superimposed on intravenous cerulein hyperstimulation."	1.30	Effect of different immunosuppressive agents on acute pancreatitis: a comparative study in an improved animal model. ( Buhr, HJ; Foitzik, T; Forgacs, B; Gebhardt, MM; Hotz, H; Klar, E; Ryschich, E, 1998)
"Among 1613 patients treated for acute pancreatitis in 1993, drug induced acute pancreatitis was diagnosed in 22 patients (incidence 1."	1.29	Drug induced acute pancreatitis: incidence and severity. ( Dröge, M; Gottesleben, F; Lankisch, PG, 1995)
"The pancreatitis was first manifested by panniculitis of the lower extremities."	1.27	Childhood systemic lupus erythematosus. Association with pancreatitis, subcutaneous fat necrosis, and calcinosis cutis. ( Gorman, H; Penneys, N; Schachner, L; Simons-Ling, N; Strauss, J; Zillereulo, G, 1983)
"Pancreatitis is not a rare occurrence in SLE, and may be related in part to the vasculitis seen during periods of disease activity."	1.26	Acute pancreatitis in systemic lupus erythematosus: report of twenty cases and a review of the literature. ( Chuong, JH; Inman, RD; Kimberly, RP; Kovacs, JE; Reynolds, JC; Walsh, MB, 1982)

Timeframe	Studies, this research(%)	All Research%
pre-1990	40 (29.41)	18.7374
1990's	14 (10.29)	18.2507
2000's	30 (22.06)	29.6817
2010's	40 (29.41)	24.3611
2020's	12 (8.82)	2.80

Article	Year
Immune Checkpoint Inhibitor-related Pancreatitis: A Case Series, Review of the Literature and an Expert Opinion. Journal of immunotherapy (Hagerstown, Md. : 1997), 2023, 09-01, Volume: 46, Issue:7 Topics: Autoimmune Pancreatitis; Azathioprine; Exocrine Pancreatic Insufficiency; Expert Testimony; Humans;	2023
Pancreatic Disorders in Patients with Inflammatory Bowel Disease. Digestive diseases and sciences, 2022, Volume: 67, Issue:2 Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Autoimmune Pancreatitis; Azathioprin	2022
Immune thrombocytopenic purpura associated with Crohn's disease with complete response to infliximab. Gastroenterologia y hepatologia, 2019, Volume: 42, Issue:1 Topics: Adrenal Cortex Hormones; Antirheumatic Agents; Azathioprine; Benzoates; Crohn Disease; Humans; Hydra	2019
Corticosteroid-associated lupus pancreatitis: a case series and systematic review of the literature. Lupus, 2019, Volume: 28, Issue:6 Topics: Acute Disease; Adolescent; Adrenal Cortex Hormones; Azathioprine; Cyclophosphamide; Dose-Response Re	2019
Thiopurine-induced pancreatitis in inflammatory bowel diseases. Expert review of gastroenterology & hepatology, 2015, Volume: 9, Issue:4 Topics: Animals; Anti-Inflammatory Agents; Azathioprine; Colitis, Ulcerative; Crohn Disease; Gastrointestina	2015
Toxicity and response to thiopurines in patients with inflammatory bowel disease. Expert review of gastroenterology & hepatology, 2015, Volume: 9, Issue:7 Topics: Azathioprine; Chemical and Drug Induced Liver Injury; Colitis, Ulcerative; Crohn Disease; Humans; Im	2015
Patients' Induced Pluripotent Stem Cells to Model Drug Induced Adverse Events: A Role in Predicting Thiopurine Induced Pancreatitis? Current drug metabolism, 2015, Volume: 17, Issue:1 Topics: Adaptive Immunity; Animals; Azathioprine; Humans; Immunosuppressive Agents; Induced Pluripotent Stem	2015
Autoimmune Pancreatitis: An Update on Diagnosis and Management. Gastroenterology clinics of North America, 2016, Volume: 45, Issue:1 Topics: Adrenal Cortex Hormones; Autoimmune Diseases; Azathioprine; Biopsy; Cholangiopancreatography, Endosc	2016
Pancreatitis in inflammatory bowel diseases. Journal of clinical gastroenterology, 2010, Volume: 44, Issue:4 Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Colitis, Ulcerative; Crohn Dis	2010
[Drug-induced pancreatitis]. Nihon rinsho. Japanese journal of clinical medicine, 2007, Oct-28, Volume: 65 Suppl 8 Topics: Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Azathioprine;	2007
Adverse effects of azathioprine. Adverse drug reactions and acute poisoning reviews, 1984,Autumn, Volume: 3, Issue:3 Topics: Alopecia; Azathioprine; Bone Marrow Diseases; Carcinogens; Drug Hypersensitivity; Drug Interactions;	1984
Drug-induced pancreatitis: a critical review. Gastroenterology, 1980, Volume: 78, Issue:4 Topics: Acetaminophen; Adrenal Cortex Hormones; Amphetamines; Asparaginase; Azathioprine; Chlorthalidone; Ch	1980
Azathioprine in inflammatory bowel disease, a safe alternative? Mediators of inflammation, 1998, Volume: 7, Issue:3 Topics: Azathioprine; Bone Marrow; Drug Hypersensitivity; Female; Fertility; Humans; Immunosuppressive Agent	1998
[Acute azathioprine-induced pancreatitis in a female patient with Crohn's disease]. Gastroenterologia y hepatologia, 1999, Volume: 22, Issue:4 Topics: Acute Disease; Adult; Azathioprine; Crohn Disease; Female; Humans; Immunosuppressive Agents; Pancrea	1999
Drug-induced acute pancreatitis. Surgery, gynecology & obstetrics, 1977, Volume: 145, Issue:1 Topics: Acute Disease; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Age Factors; Azathioprin	1977
[Pancreatitis caused by drugs]. Recenti progressi in medicina, 1977, Volume: 63, Issue:4 Topics: Adult; Azathioprine; Chlorothiazide; Contraceptives, Oral; Drug-Related Side Effects and Adverse Rea	1977
Advances in gastroenterology. The Practitioner, 1972, Volume: 209, Issue:252 Topics: Adrenal Cortex Hormones; Azathioprine; Chronic Disease; Colitis, Ulcerative; Diet; Disaccharides; Du	1972
Late medical complications of renal transplantation. Archives of internal medicine, 1969, Volume: 123, Issue:5 Topics: Adrenal Cortex Hormones; Adult; Allopurinol; Autoimmune Diseases; Azathioprine; Bone Diseases; Diabe	1969

Article	Year
How should we treat Crohn's disease? The New England journal of medicine, 1980, May-01, Volume: 302, Issue:18 Topics: Adrenal Cortex Hormones; Adult; Azathioprine; Clinical Trials as Topic; Crohn Disease; Double-Blind	1980
Subclinical exocrine pancreatic insufficiency in dogs. Journal of the American Veterinary Medical Association, 2002, Apr-15, Volume: 220, Issue:8 Topics: Animals; Azathioprine; Dietary Supplements; Disease Progression; Dog Diseases; Dogs; Enzyme Therapy;	2002
Azathioprine-related pancreatitis in patients with Crohn's disease. Gastroenterology, 1979, Volume: 77, Issue:4 Pt 2 Topics: Adult; Amylases; Azathioprine; Clinical Trials as Topic; Crohn Disease; Double-Blind Method; Female;	1979
Lack of association between azathioprine and acute pancreatitis in renal transplantation patients. Lancet (London, England), 1991, Jan-26, Volume: 337, Issue:8735 Topics: Acute Disease; Azathioprine; Cyclosporins; Drug Evaluation; Humans; Kidney Transplantation; Pancreat	1991
Hypercalcemia associated with pancreatitis and hyperamylasemia in renal transplant recipients. Data from the Minnesota randomized trial of cyclosporine versus antilymphoblast azathioprine. American journal of surgery, 1987, Volume: 154, Issue:5 Topics: Acute Disease; Amylases; Azathioprine; Clinical Trials as Topic; Cyclosporins; Humans; Hypercalcemia	1987

Article	Year
Frequency, Predisposing Factors, and Clinical Outcome of Azathioprine-Induced Pancreatitis Among Patients With Inflammatory Bowel Disease: Results From a Tertiary Referral Center. Pancreas, 2021, 10-01, Volume: 50, Issue:9 Topics: Abdominal Pain; Acute Disease; Adult; Antimetabolites, Antineoplastic; Azathioprine; Female; Hospita	2021
HLA variants associated with azathioprine-induced pancreatitis in patients with Crohn's disease. Clinical and translational science, 2022, Volume: 15, Issue:5 Topics: Acute Disease; Azathioprine; Crohn Disease; HLA-DQ alpha-Chains; HLA-DRB1 Chains; Humans; Inflammato	2022
Finding Predictors of Azathioprine-Induced Pancreatitis in Patients With Inflammatory Bowel Disease. Pancreas, 2022, 03-01, Volume: 51, Issue:3 Topics: Azathioprine; Budesonide; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Pancreatiti	2022
Azathioprine hypersensitivity syndrome manifesting as subcutaneous Sweet syndrome and acute pancreatitis. Journal of cutaneous pathology, 2023, Volume: 50, Issue:2 Topics: Acute Disease; Azathioprine; Drug Hypersensitivity Syndrome; Humans; Immunosuppressive Agents; Pancr	2023
Safety of Thioguanine in Pediatric Inflammatory Bowel Disease: A Multi-Center Case Series. Journal of pediatric gastroenterology and nutrition, 2022, 12-01, Volume: 75, Issue:6 Topics: Adolescent; Adult; Azathioprine; Child; Chronic Disease; Cohort Studies; Humans; Immunosuppressive A	2022
Drug-induced acute pancreatitis: Prevalence, Causative agents, and Outcomes. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2020, Volume: 20, Issue:7 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Azathioprine; Doxycycline; Drug-Related Side Effects and	2020
A Drug-Induced Acute Pancreatitis Retrospective Study. Canadian journal of gastroenterology & hepatology, 2020, Volume: 2020 Topics: Acute Disease; Azathioprine; Female; Humans; Male; Pancreatitis; Pharmaceutical Preparations; Retros	2020
Recurrent acute pancreatitis induced by 5-ASA and azathioprine in ulcerative colitis. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2020, Volume: 20, Issue:8 Topics: Acute Disease; Adult; Azathioprine; Colitis, Ulcerative; Humans; Male; Mesalamine; Pancreatitis; Rec	2020
Pretreatment HLADQA1-HLADRB1 Testing for the Prevention of Azathioprine-Induced Pancreatitis in Inflammatory Bowel Disease: A Prospective Cohort Study. Clinical and translational gastroenterology, 2021, 04-05, Volume: 12, Issue:4 Topics: Azathioprine; Haplotypes; HLA-DQ alpha-Chains; HLA-DRB1 Chains; Humans; Immunosuppressive Agents; In	2021
Successful use of trametinib and dasatinib combined with chemotherapy in the treatment of Ph-positive B-cell acute lymphoblastic leukemia: A case report. Medicine, 2021, Jun-25, Volume: 100, Issue:25 Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Azathioprine; Child; Consolidation Che	2021
IgG4-related disease: long-term natural history and management of a relapsing multisystem disease entity. BMJ case reports, 2017, Jul-16, Volume: 2017 Topics: Autoimmune Diseases; Azathioprine; Diagnosis, Differential; Hepatitis, Autoimmune; Humans; Immunoglo	2017
HLA-DQA1-HLA-DRB1 polymorphism is a major predictor of azathioprine-induced pancreatitis in patients with inflammatory bowel disease. Alimentary pharmacology & therapeutics, 2018, Volume: 47, Issue:5 Topics: Adult; Azathioprine; Canada; Case-Control Studies; Cohort Studies; Female; Genome-Wide Association S	2018
Relapse rate and predictors of relapse in a large single center cohort of type 1 autoimmune pancreatitis: long-term follow-up results after steroid therapy with short-duration maintenance treatment. Journal of gastroenterology, 2018, Volume: 53, Issue:8 Topics: Aged; Anti-Inflammatory Agents; Autoimmune Diseases; Azathioprine; Bile Duct Diseases; Calculi; Exoc	2018
Letter: predicting azathioprine-associated pancreatitis in IBD-phenotype or genotype? Authors' reply. Alimentary pharmacology & therapeutics, 2018, Volume: 47, Issue:7 Topics: Azathioprine; Genotype; Humans; Inflammatory Bowel Diseases; Pancreatitis; Phenotype	2018
Letter: predicting azathioprine-associated pancreatitis in IBD-phenotype or genotype? Alimentary pharmacology & therapeutics, 2018, Volume: 47, Issue:7 Topics: Azathioprine; Genotype; HLA-DQ alpha-Chains; HLA-DRB1 Chains; Humans; Inflammatory Bowel Diseases; P	2018
Autoimmune Pancreatitis and Ulcerative Rectocolitis in an Adolescent. Pediatrics, 2018, Volume: 141, Issue:Suppl 5 Topics: Acute Disease; Adolescent; Adrenal Cortex Hormones; Autoimmune Diseases; Azathioprine; Biopsy; Chola	2018
Positioning biologics-A case-based discussion: Ustekinumab. Journal of gastroenterology and hepatology, 2018, Volume: 33 Suppl 3 Topics: Adult; Antibodies, Monoclonal; Australia; Azathioprine; Biosimilar Pharmaceuticals; Crohn Disease; D	2018
Positioning biologics-A case-based discussion: Vedolizumab. Journal of gastroenterology and hepatology, 2018, Volume: 33 Suppl 3 Topics: Adult; Antibodies, Monoclonal, Humanized; Azathioprine; Biosimilar Pharmaceuticals; Crohn Disease; F	2018
Acute pancreatitis and azathioprine in paediatric inflammatory bowel disease. The Lancet. Child & adolescent health, 2019, Volume: 3, Issue:3 Topics: Acute Disease; Azathioprine; Child; Cohort Studies; Denmark; Humans; Inflammatory Bowel Diseases; Pa	2019
Association between use of azathioprine and risk of acute pancreatitis in children with inflammatory bowel disease: a Swedish-Danish nationwide cohort study. The Lancet. Child & adolescent health, 2019, Volume: 3, Issue:3 Topics: Adolescent; Azathioprine; Case-Control Studies; Child; Child, Preschool; Cohort Studies; Denmark; Fe	2019
Are thiopurines always contraindicated after thiopurine-induced pancreatitis in inflammatory bowel disease? Journal of pediatric gastroenterology and nutrition, 2013, Volume: 57, Issue:5 Topics: Adolescent; Azathioprine; Child; Child, Preschool; Contraindications; Crohn Disease; Drug Monitoring	2013
Tacrolimus as a reasonable alternative in a patient with steroid-dependent and thiopurine-refractory autoimmune pancreatitis with IgG4-associated cholangitis. Zeitschrift fur Gastroenterologie, 2014, Volume: 52, Issue:6 Topics: Aged; Azathioprine; Cholangitis; Drug Therapy, Combination; Humans; Immunoglobulin G; Immunosuppress	2014
Effect of tumor necrosis factor-α inhibitors on drug-induced pancreatitis in inflammatory bowel disease. The Annals of pharmacotherapy, 2014, Volume: 48, Issue:10 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Case-Control Studies; Drug Therapy, Co	2014
[Autoimmune pancreatitis--treatment and pitfalls in diagnostics]. Der Internist, 2014, Volume: 55, Issue:10 Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antibodies, Monoclonal, Murine-Derived; Autoimmun	2014
HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants. Nature genetics, 2014, Volume: 46, Issue:10 Topics: Azathioprine; Gene Frequency; Genetic Predisposition to Disease; Genome-Wide Association Study; Geno	2014
Successful Mercaptopurine Usage despite Azathioprine-Induced Pancreatitis in Paediatric Crohn's Disease. Journal of Crohn's & colitis, 2015, Volume: 9, Issue:8 Topics: Adolescent; Azathioprine; Child; Crohn Disease; Humans; Immunosuppressive Agents; Male; Mercaptopuri	2015
Azathioprine-induced Acute Pancreatitis in Patients with Inflammatory Bowel Diseases--A Prospective Study on Incidence and Severity. Journal of Crohn's & colitis, 2016, Volume: 10, Issue:1 Topics: Acute Disease; Adult; Age Distribution; Aged; Analysis of Variance; Azathioprine; Colitis, Ulcerativ	2016
A Pitfall to Avoid: Hyperlipasemia, Azathioprine, and Autoimmune Pancreatitis. Journal of Crohn's & colitis, 2017, Volume: 11, Issue:1 Topics: Adult; Autoimmune Diseases; Azathioprine; Colitis, Ulcerative; Female; Humans; Immunosuppressive Age	2017
A case of autoimmune pancreatitis effectively treated with an immunosuppressant (azathioprine). Clinical journal of gastroenterology, 2016, Volume: 9, Issue:5 Topics: Adult; Autoimmune Diseases; Azathioprine; Cholangiopancreatography, Endoscopic Retrograde; Humans; I	2016
Blood group B is associated with azathioprine-induced acute pancreatitis in patients with IBD. Gut, 2017, Volume: 66, Issue:8 Topics: Azathioprine; Blood Group Antigens; Colitis, Ulcerative; Crohn Disease; Humans; Immunosuppressive Ag	2017
Acute pancreatitis in inflammatory bowel disease, with special reference to azathioprine-induced pancreatitis. Alimentary pharmacology & therapeutics, 2008, Sep-01, Volume: 28, Issue:5 Topics: Acute Disease; Adult; Antimetabolites; Azathioprine; Cohort Studies; Female; Humans; Inflammatory Bo	2008
Refractory autoimmune pancreatitis: azathioprine or steroid pulse therapy? The American journal of gastroenterology, 2008, Volume: 103, Issue:7 Topics: Autoimmune Diseases; Azathioprine; Humans; Immunosuppressive Agents; Pancreatitis; Pulse Therapy, Dr	2008
[A case of acute pancreatitis induced by multiple drugs in a patient with ulcerative colitis]. The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2008, Volume: 52, Issue:3 Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites; Azathioprine; Colitis, Ulce	2008
Presentation and management of post-treatment relapse in autoimmune pancreatitis/immunoglobulin G4-associated cholangitis. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2009, Volume: 7, Issue:10 Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Autoimmune Diseases; Azathioprine; Cholang	2009
Autoimmune pancreatitis associated with myelodysplastic syndrome. International archives of allergy and immunology, 2010, Volume: 151, Issue:2 Topics: Aged; Amylases; Autoantibodies; Autoimmune Diseases; Azathioprine; Bile Ducts; Bilirubin; Blood Cell	2010
Autoimmune pancreatitis associated with various extrapancreatic lesions during a long-term clinical course successfully treated with azathioprine and corticosteroid maintenance therapy. Internal medicine (Tokyo, Japan), 2009, Volume: 48, Issue:23 Topics: Adrenal Cortex Hormones; Autoimmune Diseases; Azathioprine; Drug Therapy, Combination; Female; Heari	2009
Azathioprine or mercaptopurine-induced acute pancreatitis is not a disease-specific phenomenon. Alimentary pharmacology & therapeutics, 2010, Volume: 31, Issue:12 Topics: Acute Disease; Adolescent; Adult; Aged; Antimetabolites; Azathioprine; Crohn Disease; Female; Humans	2010
Incidence, severity, and etiology of drug-induced acute pancreatitis. Digestive diseases and sciences, 2010, Volume: 55, Issue:10 Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Azathioprine; Child; Child, Preschool; Cr	2010
Acute pancreatitis and erythema nodosum associated with azathioprine. QJM : monthly journal of the Association of Physicians, 2012, Volume: 105, Issue:4 Topics: Acute Disease; Azathioprine; Dermatitis, Atopic; Dermatologic Agents; Erythema Nodosum; Humans; Immu	2012
Azathioprine induced pancreatitis in a patient with co-existing autoimmune pancreatitis and hepatitis. JOP : Journal of the pancreas, 2011, May-06, Volume: 12, Issue:3 Topics: Abdominal Pain; Autoimmune Diseases; Azathioprine; Hepatitis, Autoimmune; Humans; Immunosuppressive	2011
Autoimmune pancreatitis: pancreatic and extrapancreatic MR imaging-MR cholangiopancreatography findings at diagnosis, after steroid therapy, and at recurrence. Radiology, 2011, Volume: 260, Issue:2 Topics: Adult; Aged; Autoimmune Diseases; Azathioprine; Cholangiopancreatography, Magnetic Resonance; Contra	2011
[Suspected pulmonary involvement of autoimmune pancreatitis]. The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2011, Volume: 58, Issue:1 Topics: Autoimmune Diseases; Azathioprine; Common Bile Duct; Emphysema; Fibrosis; Humans; Immunoglobulin G;	2011
[Two cases of thiopurine-induced acute pancreatitis in inflammatory bowel disease]. Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2012, Volume: 109, Issue:2 Topics: Acute Disease; Adolescent; Adult; Azathioprine; Humans; Inflammatory Bowel Diseases; Male; Mercaptop	2012
Gene polymorphisms involved in manifestation of leucopenia, digestive intolerance, and pancreatitis in azathioprine-treated patients. Digestive diseases and sciences, 2012, Volume: 57, Issue:9 Topics: Azathioprine; Gastrointestinal Diseases; Gene Expression Regulation; Genetic Predisposition to Disea	2012
Acute and recurrent pancreatitis in children: exploring etiological factors. Scandinavian journal of gastroenterology, 2012, Volume: 47, Issue:12 Topics: Adolescent; Azathioprine; Biliary Tract; Biliary Tract Diseases; Carrier Proteins; Child; Child, Pre	2012
The great mimicker. Gastroenterology, 2012, Volume: 143, Issue:6 Topics: Aged; Autoimmune Diseases; Azathioprine; Biopsy; Cholangiocarcinoma; Diagnosis, Differential; Female	2012
Risk of acute pancreatitis in users of azathioprine: a population-based case-control study. The American journal of gastroenterology, 2003, Volume: 98, Issue:6 Topics: Acute Disease; Adult; Azathioprine; Case-Control Studies; Denmark; Female; Humans; Immunosuppressive	2003
Acute pancreatitis after long-term therapy with mesalazine, and hyperamylasaemia associated with azathioprine in a patient with ulcerative colitis. European journal of gastroenterology & hepatology, 2003, Volume: 15, Issue:8 Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Colitis, Ulcerative; Hu	2003
TECHNIQUE OF RENAL HOMOTRANSPLANTATION. EXPERIENCE WITH 42 CASES. Archives of surgery (Chicago, Ill. : 1960), 1964, Volume: 89 Topics: Azathioprine; Dactinomycin; Diabetes Mellitus; Gastrointestinal Hemorrhage; Humans; Intestinal Obstr	1964
[Picture of the month: recurrent pancreatitis]. Ugeskrift for laeger, 2003, Sep-08, Volume: 165, Issue:37 Topics: Acute Disease; Adult; Azathioprine; Diagnosis, Differential; Humans; Male; Pancreatitis; Radiography	2003
Are drugs a risk factor of post-ERCP pancreatitis? Gastrointestinal endoscopy, 2003, Volume: 58, Issue:5 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Azathioprine; Cholangiopancreatography, Endoscopic Retro	2003
Increased incidence of azathioprine-induced pancreatitis in Crohn's disease compared with other diseases. Alimentary pharmacology & therapeutics, 2004, Oct-15, Volume: 20, Issue:8 Topics: Acute Disease; Adult; Antimetabolites; Azathioprine; Crohn Disease; Female; Humans; Male; Middle Age	2004
Azathioprine-induced pancreatitis in Crohn's disease: a smoking gun or guilt by association. Alimentary pharmacology & therapeutics, 2005, Jan-15, Volume: 21, Issue:2 Topics: Acute Disease; Aminosalicylic Acids; Antimetabolites; Azathioprine; Crohn Disease; Humans; Pancreati	2005
Acute pancreatitis with pseudocyst formation in a patient with polyarteritis nodosa. The Journal of rheumatology, 2005, Volume: 32, Issue:2 Topics: Acute Disease; Azathioprine; Cyclophosphamide; Cysts; Drug Therapy, Combination; Humans; Immunosuppr	2005
Azathioprine-induced pancreatitis in Crohn's disease: a smoking gun or guilt by association. Author's reply. Alimentary pharmacology & therapeutics, 2005, Mar-15, Volume: 21, Issue:6 Topics: Acute Disease; Antimetabolites; Azathioprine; Crohn Disease; Humans; Pancreatitis	2005
Increased rates of early adverse reaction to azathioprine in patients with Crohn's disease compared to autoimmune hepatitis: a tertiary referral center experience. The American journal of gastroenterology, 2005, Volume: 100, Issue:5 Topics: Acute Disease; Adult; Anti-Inflammatory Agents; Arthralgia; Azathioprine; Crohn Disease; Disease Sus	2005
Azathioprine pancreatitis in inflammatory bowel disease and successful subsequent treatment with mercaptopurine. Internal medicine journal, 2005, Volume: 35, Issue:9 Topics: Adult; Azathioprine; Crohn Disease; Follow-Up Studies; Humans; Immunosuppressive Agents; Male; Merca	2005
TPMT genotype and the use of thiopurines in paediatric inflammatory bowel disease. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2005, Volume: 37, Issue:12 Topics: Adolescent; Adult; Azathioprine; Bone Marrow Diseases; Chemical and Drug Induced Liver Injury; Child	2005
Pharmacogenetics of thiopurine therapy in paediatric IBD patients. Alimentary pharmacology & therapeutics, 2006, Apr-15, Volume: 23, Issue:8 Topics: Adolescent; Azathioprine; Chi-Square Distribution; Child; Female; Gene Frequency; Genetic Predisposi	2006
[Infliximab-induced hepatitis in a patient with Crohn's disease]. Gastroenterologia y hepatologia, 2006, Volume: 29, Issue:5 Topics: Acute Disease; Adult; Antibodies, Monoclonal; Azathioprine; Chemical and Drug Induced Liver Injury;	2006
Thiopurine metabolite monitoring in paediatric inflammatory bowel disease. Alimentary pharmacology & therapeutics, 2007, Apr-15, Volume: 25, Issue:8 Topics: Adolescent; Azathioprine; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Drug Hype	2007
Autoimmune pancreatitis: clinical and radiological features and objective response to steroid therapy in a UK series. The American journal of gastroenterology, 2007, Volume: 102, Issue:11 Topics: Adult; Aged; Autoimmune Diseases; Azathioprine; Cholangiopancreatography, Endoscopic Retrograde; Com	2007
[Acute pancreatitis following azathioprine therapy of crohn's disease--a case report and the overview of the literature]. Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti, 2008, Volume: 62, Issue:1 Topics: Acute Disease; Adult; Azathioprine; Crohn Disease; Female; Humans; Immunosuppressive Agents; Pancrea	2008
Are pancreatic autoantibodies associated with azathioprine-induced pancreatitis in Crohn's disease? JOP : Journal of the pancreas, 2008, May-08, Volume: 9, Issue:3 Topics: Adult; Autoantibodies; Azathioprine; Case-Control Studies; Crohn Disease; Female; Humans; Immunosupp	2008
[Conservative therapy of Crohn disease]. Medizinische Klinik, 1982, Jan-29, Volume: 77, Issue:3 Topics: Adrenal Cortex Hormones; Azathioprine; Crohn Disease; Humans; Pancreatitis; Psychotherapy; Pyridazin	1982
Acute pancreatitis in systemic lupus erythematosus: report of twenty cases and a review of the literature. Medicine, 1982, Volume: 61, Issue:1 Topics: Acute Disease; Adolescent; Adult; Aged; Amylases; Azathioprine; Female; Humans; Lupus Erythematosus,	1982
Azathioprine and acute pancreatitis: studies with an isolated perfused canine pancreas. The Journal of surgical research, 1983, Volume: 34, Issue:2 Topics: Acute Disease; Amylases; Animals; Azathioprine; Blood Glucose; Disease Models, Animal; Dogs; Pancrea	1983
Azathioprine-associated acute pancreatitis in the course of chronic active hepatitis. Digestive diseases and sciences, 1984, Volume: 29, Issue:1 Topics: Acute Disease; Adult; Azathioprine; Hepatitis B Surface Antigens; Hepatitis, Chronic; Humans; Male;	1984
Azathioprine-induced shock. British medical journal (Clinical research ed.), 1981, Dec-05, Volume: 283, Issue:6305 Topics: Aged; Arthritis, Rheumatoid; Azathioprine; Humans; Male; Pancreatitis	1981
Childhood systemic lupus erythematosus. Association with pancreatitis, subcutaneous fat necrosis, and calcinosis cutis. Archives of dermatology, 1983, Volume: 119, Issue:6 Topics: Adipose Tissue; Azathioprine; Calcinosis; Child; Female; Humans; Hydrochlorothiazide; Lupus Erythema	1983
Rheumatoid arthritis: treatment with azathioprine (IMURAN (R)). Clinical side-effects and laboratory abnormalities. Annals of the rheumatic diseases, 1982, Volume: 41 Suppl 1 Topics: Adult; Aged; Anorexia; Arthritis, Rheumatoid; Azathioprine; Bacterial Infections; Chemical and Drug	1982
Azathioprine-induced pancreatitis. Arthritis and rheumatism, 1982, Volume: 25, Issue:9 Topics: Azathioprine; Humans; Pancreatitis	1982
Drug induced acute pancreatitis: incidence and severity. Gut, 1995, Volume: 37, Issue:4 Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Azathioprine; Didanosine; Estrogens; Female; Furosemi	1995
Peritoneal lavage therapy for severe acute pancreatitis after renal transplantation. Nephron, 1996, Volume: 74, Issue:2 Topics: Acute Disease; Adult; Azathioprine; Cyclosporine; Humans; Immunosuppressive Agents; Kidney Transplan	1996
[Acute pancreatitis caused by azathioprine in patient with Crohn disease]. Revista espanola de enfermedades digestivas, 1996, Volume: 88, Issue:9 Topics: Acute Disease; Adult; Azathioprine; Crohn Disease; Female; Humans; Immunosuppressive Agents; Pancrea	1996
[Pancreatitis caused by azathioprine: immuno-allergy?]. Presse medicale (Paris, France : 1983), 1996, Nov-09, Volume: 25, Issue:34 Topics: Acute Disease; Adult; Azathioprine; Crohn Disease; Drug Hypersensitivity; Humans; Male; Pancreatitis	1996
Pancreatitis in patients with inflammatory bowel disease. Journal of pediatric gastroenterology and nutrition, 1997, Volume: 25, Issue:1 Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Azathioprine;	1997
Drug-associated pancreatitis: facts and fiction. Pancreas, 1997, Volume: 15, Issue:2 Topics: Acute Disease; Azathioprine; Furosemide; Humans; Pancreatitis; Sulfonamides; Tetracycline	1997
Effect of different immunosuppressive agents on acute pancreatitis: a comparative study in an improved animal model. Transplantation, 1998, Apr-27, Volume: 65, Issue:8 Topics: Acute Disease; Animals; Azathioprine; Cyclosporine; Immunosuppressive Agents; Male; Muromonab-CD3; N	1998
Summary of the workshop on 6-mercaptopurine/azathioprine pharmacology. Inflammatory bowel diseases, 1998, Volume: 4, Issue:2 Topics: Adult; Azathioprine; Child; Colitis, Ulcerative; Crohn Disease; Drug Interactions; Drug Therapy, Com	1998
Toxicity of 6-mercaptopurine/azathioprine in patients with inflammatory bowel disease. Inflammatory bowel diseases, 1998, Volume: 4, Issue:2 Topics: Adolescent; Adult; Azathioprine; Bone Marrow; Child; Colorectal Neoplasms; Drug Hypersensitivity; Fe	1998
Post-renal transplant azathioprine-induced pancreatitis. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1999, Volume: 14, Issue:10 Topics: Azathioprine; Humans; Immunosuppressive Agents; Kidney Transplantation; Magnetic Resonance Imaging;	1999
Intracystic hemorrhage of pancreatic serous cystadenoma after renal transplantation: report of a case. Surgery today, 2000, Volume: 30, Issue:7 Topics: Adult; Azathioprine; Cystadenoma, Serous; Disease Progression; Hemorrhage; Humans; Immunosuppressive	2000
[Pancreatitis in a patient with Crohn disease treated with mesalazine and azathioprine]. Ugeskrift for laeger, 2000, Aug-21, Volume: 162, Issue:34 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Crohn Disease; Female; Humans; Mesalam	2000
Prevention of pancreatitis by weekly amylase assay in patients with Crohn's disease treated with azathioprine. The American journal of gastroenterology, 2000, Volume: 95, Issue:9 Topics: Amylases; Azathioprine; Biomarkers; Crohn Disease; Humans; Immunoenzyme Techniques; Immunosuppressiv	2000
[Acute pancreatitis after kidney transplantation]. Magyar sebeszet, 2001, Volume: 54, Issue:2 Topics: Acute Disease; Adrenal Cortex Hormones; Adult; Azathioprine; Cadaver; Cyclosporine; Female; Humans;	2001
Elevated serum pancreatic enzyme activities in kidney transplant recipients and azathioprine drug therapy: is thiopurine methyltransferase polymorphism one missing link? Urologia internationalis, 2002, Volume: 68, Issue:2 Topics: Alleles; Amylases; Azathioprine; Female; Humans; Immunosuppressive Agents; Kidney Transplantation; L	2002
[Pancreatic involvement in inflammatory bowel diseases in children]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2002, Volume: 9, Issue:5 Topics: Adolescent; Amylases; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Child; Colitis, Ulcerat	2002
[Drug-induced acute pancreatitis (author's transl)]. Igaku kenkyu. Acta medica, 1979, Volume: 49, Issue:3 Topics: Acute Disease; Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Aged; Azathi	1979
Azathioprine as a treatment modality in acute hemorrhagic pancreatitis. Surgical forum, 1978, Volume: 29 Topics: Acute Disease; Animals; Azathioprine; Dogs; Hemorrhage; Pancreatic Diseases; Pancreatitis; Survival	1978
Acute pancreatitis associated with long-term azathioprine therapy. Occurrence in a patient with systemic lupus erythematosus. Archives of dermatology, 1979, Volume: 115, Issue:2 Topics: Acute Disease; Adult; Azathioprine; Female; Humans; Lupus Erythematosus, Systemic; Pancreatitis; Pre	1979
Amelioration of pancreatitis with azathioprine. The American journal of gastroenterology, 1979, Volume: 72, Issue:3 Topics: Acute Disease; Animals; Azathioprine; Bile; Dogs; Female; Male; Pancreatitis; Trypsin	1979
Pancreatitis, amylase clearance, and azathioprine. The Journal of pediatrics, 1978, Volume: 93, Issue:6 Topics: Adolescent; Amylases; Azathioprine; Creatinine; Humans; Male; Pancreatitis	1978
Azathioprine-associated acute pancreatitis. The American journal of digestive diseases, 1977, Volume: 22, Issue:9 Topics: Acute Disease; Adult; Azathioprine; Crohn Disease; Granuloma; Humans; Male; Pancreatitis	1977
Consistent protection from pancreatitis in canine pancreas allografts treated with 5-fluorouracil. The Journal of surgical research, 1975, Volume: 18, Issue:3 Topics: Administration, Oral; Animals; Autopsy; Azathioprine; Dogs; Drug Synergism; Female; Fluorouracil; In	1975
Prolongation of pancreatic allograft survival by 5-fluorouracil. American journal of surgery, 1975, Volume: 130, Issue:1 Topics: Animals; Azathioprine; Dogs; Fluorouracil; Graft Rejection; Humans; Immunosuppression Therapy; Pancr	1975
[Azathioprine-induced acute pancreatitis]. Annales de gastroenterologie et d'hepatologie, 1990, Volume: 26, Issue:5 Topics: Acute Disease; Adult; Azathioprine; Female; Humans; Pancreatitis	1990
Effect of cyclosporine on the endocrine and exocrine pancreas in kidney transplant recipients. American journal of kidney diseases : the official journal of the National Kidney Foundation, 1988, Volume: 12, Issue:1 Topics: Acute Disease; Adult; Amylases; Azathioprine; Blood Glucose; Cyclosporins; Diabetes Mellitus; Drug T	1988
[Proven relationship between drugs and pancreatitis]. Deutsche medizinische Wochenschrift (1946), 1986, May-30, Volume: 111, Issue:22 Topics: Asparaginase; Azathioprine; Diuretics; Drug-Related Side Effects and Adverse Reactions; Estrogens; H	1986
Acute pancreatitis in two dogs given azathioprine and prednisone. Journal of the American Veterinary Medical Association, 1987, Sep-15, Volume: 191, Issue:6 Topics: Acute Disease; Animals; Azathioprine; Dog Diseases; Dogs; Drug Synergism; Male; Pancreatitis; Predni	1987
[Life-threatening interaction between azathioprine and allopurinol]. Der Internist, 1985, Volume: 26, Issue:11 Topics: Allopurinol; Azathioprine; Chemical and Drug Induced Liver Injury; Drug Synergism; Drug Therapy, Com	1985
[Acute drug-induced pancreatitis]. Schweizerische medizinische Wochenschrift, 1985, Jun-22, Volume: 115, Issue:25 Topics: Acute Disease; Asparaginase; Azathioprine; Chlorothiazide; Drug-Related Side Effects and Adverse Rea	1985
Profound circulatory collapse due to azathioprine. Journal of the Royal Society of Medicine, 1985, Volume: 78, Issue:12 Topics: Acute Kidney Injury; Arthritis, Rheumatoid; Azathioprine; Female; Humans; Jaundice; Middle Aged; Pan	1985
Application of therapeutic agents to alter the course of acute hemorrhagic pancreatitis in dogs. International surgery, 1974, Volume: 59, Issue:5 Topics: Acute Disease; Aminocaproates; Animals; Aprotinin; Azathioprine; Bile; Bile Ducts; Convalescence; Do	1974
Pancreatitis after renal transplantation. American journal of surgery, 1972, Volume: 123, Issue:3 Topics: Adult; Azathioprine; Female; Glomerulonephritis; Graft Rejection; Humans; Kidney Failure, Chronic; K	1972
Acute pancreatitis and hyperamylasemia in renal homograft recipients. Archives of surgery (Chicago, Ill. : 1960), 1972, Volume: 105, Issue:2 Topics: Adolescent; Adult; Amylases; Azathioprine; Calcium; Cholelithiasis; Creatinine; Female; Humans; Hype	1972
[Therapy of enteritis regional Crohn using azathioprine]. Deutsche medizinische Wochenschrift (1946), 1973, Jun-22, Volume: 98, Issue:25 Topics: Abscess; Azathioprine; Crohn Disease; Humans; Pancreatitis; Prospective Studies; Sepsis	1973
Azathioprine-induced acute pancreatitis. The New England journal of medicine, 1973, Aug-16, Volume: 289, Issue:7 Topics: Acute Disease; Adolescent; Azathioprine; Crohn Disease; Female; Humans; Pancreatitis	1973
[Acute pancreatitis after renal transplantation]. Acta chirurgica Belgica, 1967, Volume: 66, Issue:3 Topics: Acute Disease; Adult; Azathioprine; Cadaver; Female; Glomerulonephritis; Humans; Kidney Transplantat	1967
Endocrine function of the pancreatic allograft. Endocrinology, 1968, Volume: 82, Issue:4 Topics: Animals; Azathioprine; Blood Glucose; Dogs; Glucose Tolerance Test; Graft vs Host Disease; Hyperglyc	1968
Acute pancreatitis as a complication of Imuran therapy in regional enteritis. Gastroenterology, 1972, Volume: 62, Issue:5 Topics: Acute Disease; Amylases; Azathioprine; Crohn Disease; Female; Humans; Middle Aged; Pancreatitis; Tim	1972
Positioning biological agents: Session two summary. Journal of gastroenterology and hepatology, 2018, Volume: 33 Suppl 3 Topics: Adult; Antibodies, Monoclonal, Humanized; Crohn Disease; Digestive System Surgical Procedures; Femal	2018
Risk factors for serious adverse effects of thiopurines in patients with Crohn's disease. Current drug safety, 2013, Volume: 8, Issue:3 Topics: Adolescent; Adult; Age Factors; Chemical and Drug Induced Liver Injury; Cohort Studies; Crohn Diseas	2013

azathioprine and Pancreatitis

Research Excerpts

Research

Studies (136)

Authors

Reviews

Trials

Other Studies

Authors	Studies
Eskazan, T	1
Bozcan, S	1
Atay, K	1
Yildirim, S	1
Demir, N	1
Celik, S	1
Tuncer, M	1
Hatemi, I	1
Celik, AF	1
Erzin, Y	1
Ås, J	1
Bertulyte, I	1
Eriksson, N	1
Magnusson, PKE	1
Wadelius, M	1
Hallberg, P	1
Freitas, M	1
Lima Capela, T	1
Macedo Silva, V	1
Arieira, C	1
Cúrdia Gonçalves, T	1
Dias de Castro, F	1
Moreira, MJ	1
Firmino-Machado, J	1
Cotter, J	1
Thomas, JL	1
Tee, MW	1
Harp, J	1
Magro, C	1
Bayoumy, AB	1
Jagt, JZ	1
van Wering, HM	1
de Ridder, L	2
Hummel, T	1
Wolters, VM	1
Stapelbroek, J	1
Benninga, MA	2
Mulder, CJJ	1
de Boer, NKH	1
de Meij, TGJ	1
Kramer, S	1
van Hee, K	1
Blokzijl, H	1
van der Heide, F	1
Visschedijk, MC	1
Chadalavada, P	1
Simons-Linares, CR	1
Chahal, P	1
Gagnon, AL	1
Lavoie, A	1
Frigon, MP	1
Michaud-Herbst, A	1
Tremblay, K	1
Hegyi, PJ	1
Szakács, Z	1
Faluhelyi, N	1
Németh, BC	1
Bajor, J	1
Hegyi, P	1
Montenegro, ML	1
Corral, JE	1
Lukens, FJ	1
Ji, B	1
Kröner, PT	1
Farraye, FA	1
Bi, Y	1
Wilson, A	3
Wang, Q	1
Choi, YH	1
Ponich, T	3
Gregor, JC	3
Chande, N	3
Yan, B	3
Sey, M	3
Beaton, M	3
Kim, RB	3
Wang, J	1
Shen, SH	1
Hu, BF	1
Wang, GL	1
Kotha, S	1
Tritto, G	1
Wong, T	1
Berry, P	1
Jansen, LE	2
Rose, RV	2
Khanna, R	2
Jairath, V	2
Khanna, N	2
McIntosh, K	2
Teft, WA	2
Lee, HW	1
Moon, SH	1
Kim, MH	1
Cho, DH	1
Jun, JH	1
Nam, K	1
Song, TJ	1
Park, DH	1
Lee, SS	1
Seo, DW	1
Lee, SK	1
Teich, N	3
Bruns, T	2
Stallmach, A	3
Brunet, E	1
Martínez de Sola, M	1
Garcia-Iglesias, P	1
Calvet, X	1
Cousin, E	1
Cousin, I	1
Aziz, K	1
Chailloux, P	1
Breton, E	1
Begun, J	1
Sparrow, M	1
Aloi, M	1
Cucchiara, S	1
Wintzell, V	1
Svanström, H	1
Olén, O	1
Melbye, M	1
Ludvigsson, JF	1
Pasternak, B	1
Dwivedi, P	1
Kumar, RR	1
Dhooria, A	1
Adarsh, MB	1
Malhotra, S	1
Kakkar, N	1
Naidu, S	1
Sharma, SK	1
Sharma, A	2
Jain, S	1
Dhir, V	1
Ledder, OD	1
Lemberg, DA	2
Ooi, CY	2
Day, AS	3
Buechter, M	1
Klein, CG	1
Kloeters, C	1
Schlaak, JF	1
Canbay, A	1
Gerken, G	1
Kahraman, A	1
Stobaugh, DJ	1
Deepak, P	1
Rasch, S	1
Phillip, V	1
Weirich, G	1
Esposito, I	1
Gaa, J	1
Schmid, RM	1
Algül, H	1
Heap, GA	1
Weedon, MN	1
Bewshea, CM	1
Singh, A	1
Chen, M	1
Satchwell, JB	1
Vivian, JP	1
So, K	1
Dubois, PC	1
Andrews, JM	1
Annese, V	1
Bampton, P	1
Barnardo, M	1
Bell, S	1
Cole, A	1
Connor, SJ	1
Creed, T	1
Cummings, FR	1
D'Amato, M	1
Daneshmend, TK	1
Fedorak, RN	1
Florin, TH	1
Gaya, DR	1
Greig, E	1
Halfvarson, J	1
Hart, A	1
Irving, PM	2
Jones, G	1
Karban, A	2
Lawrance, IC	1
Lee, JC	1
Lees, C	1
Lev-Tzion, R	1
Lindsay, JO	1
Mansfield, J	1
Mawdsley, J	1
Mazhar, Z	1
Parkes, M	1
Parnell, K	1
Orchard, TR	1
Radford-Smith, G	1
Russell, RK	1
Reffitt, D	1
Satsangi, J	1
Silverberg, MS	1
Sturniolo, GC	1
Tremelling, M	1
Tsianos, EV	1
van Heel, DA	1
Walsh, A	1
Watermeyer, G	1
Weersma, RK	4
Zeissig, S	1
Rossjohn, J	1
Holden, AL	1
Ahmad, T	1
Ledder, O	1
Goldberg, R	1
Gallego-Gutiérrez, S	1
Navas-López, VM	1
Kolorz, M	2
Bartosova, L	2
Lukac, K	1
Luque-Pérez, S	1
Núñez-Caro, L	1
García-Galán, P	1
Fernández-Crehuet, FG	1
Blasco-Alonso, J	1
Serrano-Nieto, MJ	1
Sierra-Salinas, C	1
Mohl, W	2
Bokemeyer, B	2
Bündgens, B	1
Büning, J	1
Miehlke, S	1
Hüppe, D	1
Maaser, C	1
Klugmann, T	1
Kruis, W	1
Siegmund, B	1
Helwig, U	1
Weismüller, J	1
Drabik, A	1
Stocco, G	2
Lanzi, G	1
Yue, F	1
Giliani, S	1
Sasaki, K	1
Tommasini, A	1
Pelin, M	1
Martelossi, S	3
Ventura, A	3
Decorti, G	2
Madhani, K	1
Farrell, JJ	1
Hernanz, N	1
Lopez-Sanroman, A	2
Yamabe, A	1
Irisawa, A	1
Notohara, K	1
Shibukawa, G	1
Fujisawa, M	1
Sato, A	1
Yoshida, Y	1
Arakawa, N	1
Ikeda, T	1
Igarashi, R	1
Maki, T	1
Yamamoto, S	1
Walldorf, J	1
Schmidt, C	1
Bermejo, F	1
Taxonera, C	1
Gisbert, JP	1
Pérez-Calle, JL	1
Vera, I	1
Menchén, L	1
Martín-Arranz, MD	1
Opio, V	1
Carneros, JA	1
Van-Domselaar, M	1
Mendoza, JL	1
Luna, M	1
López, P	1
Calvo, M	1
Algaba, A	1
Matsushita, M	1
Ikeura, T	1
Fukui, T	1
Uchida, K	1
Okazaki, K	1
Son, CN	1
Lee, HL	1
Joo, YW	1
Lee, OY	1
Han, DS	1
Yoon, BC	1
Choi, HS	1
Hahm, JS	1
Sandanayake, NS	1
Church, NI	2
Chapman, MH	1
Johnson, GJ	1
Dhar, DK	1
Amin, Z	2
Deheragoda, MG	2
Novelli, M	2
Winstanley, A	1
Rodriguez-Justo, M	2
Hatfield, AR	2
Pereira, SP	2
Webster, GJ	2
Tabata, R	1
Tabata, C	1
Okamoto, T	1
Omori, K	1
Terada, M	1
Nagai, T	1
Naitoh, I	1
Nakazawa, T	1
Ohara, H	1
Sano, H	1
Ando, T	2
Hayashi, K	1
Tanaka, H	1
Okumura, F	1
Miyabe, K	1
Yoshida, M	1
Takahashi, S	1
Joh, T	1
Pitchumoni, CS	1
Rubin, A	1
Das, K	1
van Geenen, EJ	1
de Boer, NK	1
Stassen, P	1
Linskens, RK	1
Bruno, MJ	1
Mulder, CJ	1
Stegeman, CA	1
van Bodegraven, AA	1
Vinklerová, I	1
Procházka, M	1
Procházka, V	1
Urbánek, K	1
Lai, SW	1
Wang, YC	1
Wang, CH	1
Huang, TY	1
Venkatesh, PG	1
Navaneethan, U	1
Manfredi, R	1
Frulloni, L	1
Mantovani, W	1
Bonatti, M	1
Graziani, R	1
Pozzi Mucelli, R	1
Bang, S	1
Park, JY	1
Nishikawa, J	1
Kudo, T	1
Miyazaki, T	1
Mihara, H	1
Ueda, A	1
Kajiura, S	1
Fujinami, H	1
Ogawa, K	1
Hosokawa, A	1
Sugiyama, T	1
Wroblova, K	1
Batovsky, M	1
Zboril, V	1
Suchankova, J	1
Bartos, M	1
Ulicny, B	1
Pav, I	1
Minen, F	1
De Cunto, A	1
Gómez, V	1
Michel, JA	1
Floyd, A	1
Pedersen, L	1
Nielsen, GL	1
Thorlacius-Ussing, O	1
Sorensen, HT	1
Toubanakis, C	1
Batziou, E	1
Sipsas, N	1
Galanopoulos, G	1
Tzivras, M	1
Archimandritis, A	1
STARZL, TE	2
MARCHIORO, TL	1
DICKINSON, TC	1
RIFKIND, D	1
STONINGTON, OG	1
WADDELL, WR	1
Johansen, TL	1
Kromann-Andersen, H	1
Perney, P	1
Berthier, E	1
Pageaux, GP	1
Hillaire-Buys, D	1
Roques, V	1
Fabbro-Peray, P	1
Melki, M	1
Hanslik, B	1
Bauret, P	1
Larrey, D	1
Blayac, JP	1
Blanc, F	1
Peters, FT	2
Oostenbrug, LE	1
van den Berg, AP	1
van Haastert, M	1
Ploeg, RJ	1
Posthumus, MD	1
Homan van der Heide, JJ	1
Jansen, PL	1
van Dullemen, HM	3
Mardini, HE	1
Suresh, E	1
Beadles, W	1
Welsby, P	1
Luqmani, R	1
Bajaj, JS	1
Saeian, K	1
Varma, RR	1
Franco, J	1
Knox, JF	1
Podoll, J	1
Emmons, J	1
Levy, M	1
Binion, DG	1
Alexander, S	1
Dowling, D	1
Barabino, A	1
Fontana, M	1
Lionetti, P	1
Malusà, N	1
Bartoli, F	1
Fezzi, M	1
Giraldi, T	1
Van Dieren, JM	1
Van Deventer, HJ	1
Stokkers, PC	1
Van der Woude, JC	1
Van Vuuren, AJ	1
Escher, JC	1
Hommes, DW	1
Soto-Fernández, S	1
González-Carro, P	1
De Pedro-Esteban, A	1
Legaz-Huidobro, ML	1
Pérez-Roldán, F	1
Roncero García-Escribano, O	1
Valbuena-González, M	1
Ruiz-Carrillo, F	1
Bohane, TD	1
Lee, D	1
Naidoo, D	1
Sandanayake, N	1
Lees, WR	1
Gillams, A	1
Seward, EW	1
Kozu, T	1
Sinkovic, A	1
Koren, M	1
Skok, P	1
Potrc, S	1
Batstra, MR	1
Kleibeuker, JH	1
Sleisenger, MH	1
Wuchter, J	1
Reynolds, JC	1
Inman, RD	1
Kimberly, RP	1
Chuong, JH	1
Kovacs, JE	1
Walsh, MB	1
Broe, PJ	1
Cameron, JL	1
Lawson, DH	1
Lovatt, GE	1
Gurton, CS	1
Hennings, RC	1
Guillaume, P	1
Grandjean, E	1
Malè, PJ	1
Pozniak, AL	2
Ahern, M	1
Blake, DR	1
Simons-Ling, N	1
Schachner, L	1
Penneys, N	1
Gorman, H	1
Zillereulo, G	1
Strauss, J	1
Mallory, A	1
Kern, F	1
Whisnant, JK	1
Pelkey, J	1
Lankisch, PG	1
Dröge, M	1
Gottesleben, F	1
Yagisawa, T	1
Toma, H	1
Takahashi, K	1
Tanabe, K	1
Tokumoto, N	1
Iguchi, Y	1
Teraoka, S	1
Ota, K	2
Echarri, A	1
Borda, F	1
Jiménez, FJ	1
Arín, A	1
Martín-Granizo, I	1
Aznarez, R	1
Aissaoui, M	1
Mounedji, N	1
Mathelier-Fusade, P	1
Leynadier, F	1
Keljo, DJ	1
Sugerman, KS	1
Frick, T	1
Foitzik, T	1
Forgacs, B	1
Ryschich, E	1
Hotz, H	1
Gebhardt, MM	1
Buhr, HJ	1
Klar, E	1
Markowitz, JF	1
Marion, JF	1
Tanis, AA	1
Velicia, MR	1
González, JM	1
Fernández, P	1
Remacha, B	1
Martín, MA	1
Sánchez, G	1
Goyeneche, ML	1
Caro-Paton, A	1
Siwach, V	1
Bansal, V	1
Kumar, A	1
Rao Ch, U	1
Minz, M	1
Sakaguchi, T	1
Nakamura, S	1
Suzuki, S	1
Konno, H	1
Fujita, K	1
Suzuki, K	1
Ushiyama, T	1
Ishikawa, A	1
Harada, M	1
Baba, S	1
Glintborg, B	1
Castiglione, F	1
Del Vecchio Blanco, G	1
Rispo, A	1
Mazzacca, G	1
Asztalos, L	1
Kincses, Z	1
Berczi, C	1
Szabo, L	1
Fedor, R	1
Locsey, L	1
Balzs, G	1
Steiner, M	1
Burmeister, D	1
Bastian, M	1
Seiter, H	1
Schuff-Werner, P	1
Wiberg, ME	1
Westermarck, E	1
Le Large-Guiheneuf, C	1
Hugot, JP	1
Faure, C	1
Munck, A	1
Mougenot, JF	1
Navarro, J	1
Cézard, JP	1
Sturdevant, RA	1
Singleton, JW	1
Deren, JL	1
Law, DH	1
McCleery, JL	1
Nakashima, Y	2
Howard, JM	1
Rambaldi, M	1
Russo, R	1
Iaquinto, G	1
Agozzino, L	1
De Cristofano, R	1
Kerstein, MD	2
Grabman, JP	1
Herskowitz, LJ	1
Olansky, S	1
Lang, PG	1
Grabman, J	1
Isenberg, JN	1
Paloyan, D	1
Levin, B	1
Simonowitz, D	1
Castellanos, J	2
Manifacio, G	2
Toledo-Pereyra, LH	1
Shatney, CH	2
Lillehei, RC	2
Toledo-Pereyra, L	1
Frick, TW	2
Fryd, DS	2
Goodale, RL	2
Simmons, RL	2
Sutherland, DE	2
Najarian, JS	2
Roblin, X	1
Becot, F	1
Jacquot, JM	1
Nairi, A	1
Abinader, J	1
Monnet, D	1
Yoshimura, N	1
Nakai, I	1
Ohmori, Y	1
Aikawa, I	1
Fukuda, M	1
Yasumura, T	1
Matsui, S	1
Hamashima, T	1
Oka, T	1
Dobrilla, G	2
Felder, M	2
Chilovi, F	2
Moriello, KA	1
Bowen, D	1
Meyer, DJ	1
Greif, J	1
Erdmann, E	1
Major, GA	1
Moore, PG	1
Khedroo, LG	1
Renning, JA	1
Warden, GD	1
Stevens, LE	1
Reemtsma, K	1
Penn, I	1
Durst, AL	1
Machado, M	1
Halgrimson, CG	1
Booth, AS	1
Putman, CW	1
Groth, CG	1
Thomson, TJ	1
Thiele, KG	1
Kawanishi, H	1
Rudolph, E	1
Bull, FE	1
Van Geertruyden, J	1
Toussaint, C	1
Ginn, HE	1
Mori, S	1
Inou, T	1
Kanazawa, Y	1
Kuzuya, T	1
Nogueira, JR	1
Freedman, MA	1
Leong, RW	1
Mazor, Y	1
Koifman, E	1
Elkin, H	1
Chowers, Y	1
Krivoy, N	1
Efrati, E	1